AdipoRon

Catalog No.S7365 Synonyms: SC-396658

AdipoRon Chemical Structure

Molecular Weight(MW): 428.52

AdipoRon is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.

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Cited by 2 Publications

1 Customer Review

  • AdipoRon attenuates Ang II-induced vascular injury. (A) Immunofluorescence analysis of p-p38 and quantification of its protein expression levels, in Sham, Ang II and Ang II+ AdipoRon-treated mice (scale bar, 100 µm). Representative images of (B) Sirius Red (scale bar, 200 µm) and (C) hematoxylin and eosin staining (scale bar, 50 µM) of aorta cross sections from sham, Ang II and Ang II+ AdipoRon-treated mice. Data are expressed as the mean ± standard deviation (n=5). *P<0.05 vs. sham, #P<0.05 vs. Ang II. Ang II, angiotensin; p-p38, phosphorylated-p38

    Mol Med Rep, 2018, 17(1):209-215. AdipoRon purchased from Selleck.

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Choose Selective AdipoR Inhibitors

Biological Activity

Description AdipoRon is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.
Features Orally bioavailable adiponectin receptor agonist that can be used for the treatment of obesity-related diseases.
Targets
AdipoR1 [1] AdipoR2 [1]
1.8 μM(Kd) 3.1 μM(Kd)
In vitro

AdipoRon increases AMPK activation, PGC-1α expression and mitochondrial biogenesis by binding to both AdipoR1 and AdipoR2 in C2C12 myotubes. [1]

In vivo In skeletal muscle and liver of wild-type mice AdipoRon (50 mg/kg, i.v.) significantly induces phosphorylation of AMPK via AdipoR1 and AdipoR2. In WT mice, AdipoRon (50 mg/kg, p.o.) improves insulin resistance, glucose intolerance and dyslipidaemia by activating AdipoR1–AMPK–PGC-1α pathways in skeletal muscle, while by activating AdipoR2–PPAR-α pathways in the liver. Moreover, AdipoRon ameliorates diabetes of genetically obese rodent model db/db mice, and prolongs the shortened lifespan of db/db mice on a high-fat diet. [1]

Protocol

Solubility (25°C)

In vitro DMSO 86 mg/mL (200.69 mM)
Ethanol 50 mg/mL (116.68 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 428.52
Formula

C27H28N2O3

CAS No. 924416-43-3
Storage powder
in solvent
Synonyms SC-396658

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID