Name: Anle138b
Brand: Selleck Chemicals
SKU: S6782
Rating: 5 (1 reviews)

Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease.

Anle138b Chemical Structure

CAS: 882697-00-9

Purity & Quality Control

Batch: S678201 DMSO] 69 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.99%

99.99

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Biological Activity

Description

Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease.

Targets

PrP(Sc) ^[1]

α-synuclein ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04685265	Completed	Parkinson Disease	MODAG GmbH\|Aptuit\|Quotient Sciences\|Nottingham University Hospitals NHS Trust	December 22 2020	Phase 1
NCT04208152	Completed	Healthy Volunteers	MODAG GmbH\|Quotient Sciences\|Aptuit	December 6 2019	Phase 1

References

[1] Wagner J, et al. Acta Neuropathol. 2013 Jun;125(6):795-813.

Chemical Information & Solubility

Molecular Weight	343.17	Formula	C₁₆H₁₁BrN₂O₂
CAS No.	882697-00-9	SDF	--
Smiles	C1OC2=C(O1)C=C(C=C2)C3=CC(=NN3)C4=CC(=CC=C4)Br
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 69 mg/mL ( (201.06 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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