Alfuzosin HCl

For research use only.

Catalog No.S1409

1 publication

Alfuzosin HCl  Chemical Structure

CAS No. 81403-68-1

Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).

Selleck's Alfuzosin HCl has been cited by 1 publication

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  • PC-3 and LNCaP cell viability following treatment with a1-adrenoceptor antagonists. (A) Cells were treated with drug (0.01-100 μM) for 72 hr and cell viability determined using the resazurin reduction assay. (B) Effect of treatment duration on PC-3 and LNCap cell survival following treatment with doxazosin (30 μM) or prazosin (30 μM). Survival is expressed as the percentage values of untreated vehicle control and values are the mean ( sem) of six independent determinations each conducted in triplicate. *P<0.05, ***P<0.001 compared to corresponding values for LNCap cells.

    Prostate, 2016, 76(8):757-66.. Alfuzosin HCl purchased from Selleck.

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Biological Activity

Description Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).
α1-adrenergic receptor [1]
In vitro

Alfuzosin significantly increases whole-cell peak sodium (hNa(v)1.5) current, increases the probability of late hNa(v)1.5 single-channel openings, and significantly shortens the slow time constant for recovery from inactivation. Alfuzosin also increases hNa(v)1.5 burst duration and number of openings per burst between 2- and 3-fold. [1] Alfuzosin shows a concentration-dependent relaxing effect on rabbit corpus cavernosum (CC) pre-contracted by 10 mM phenylephrine. [2]

In vivo Alfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts. [1] Alfuzosin enhances the number and amplitude of erections induced by apomorphine in spontaneous hypertensive rats (SHR). [3] Alfuzosin behaves as an alpha-adrenergic antagonist blocking the contractions induced by exogenous noradrenaline without altering spikes in both portions of the vas deferens. [4] Alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibits pressor responses produced by the alpha 1-selective agonist, Cirazoline but inhibits only slightly responses to the alpha 2-selective agonist, UK 14,304, in the pithed rat. Alfuzosin (1 mg kg-1, i.v.) has minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia). Alfuzosin (0.001-1 mg kg-1, i.v.) and Prazosin (0.001-0.3 mg kg-1, i.v.) produces dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves in the anaesthetized cat. [5]


Solubility (25°C)

In vitro DMSO 85 mg/mL warmed (199.57 mM)
Water 85 mg/mL (199.57 mM)
Ethanol 85 mg/mL (199.57 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 425.91


CAS No. 81403-68-1
Storage powder
in solvent
Synonyms N/A
Smiles CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01685658 Withdrawn Drug: Intravenous ketoprofen|Drug: Intravenous paracetamol Renal Colic|Acute Renal Colic Centre Hospitalier Universitaire de Nīmes September 2016 Phase 4
NCT00637715 Completed Drug: Alfuzosin Benign Prostatic Hyperplasia Sanofi October 2003 Phase 4
NCT00290030 Completed Drug: Alfuzosin Prostatic Hyperplasia|Acute Urinary Retention Sanofi May 2001 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID