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Alprostadil (PGE1) PGES agonist

Name: Alprostadil (PGE1)
Brand: Selleck Chemicals
SKU: S1508
Availability: InStock
Rating: 5 (5 reviews)

Cat.No.S1508

Alprostadil (PGE1) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.

Alprostadil (PGE1) PGES agonist Chemical Structure

Quality Control

Batch: S150850 DMSO]71 mg/mL]false]Ethanol]71 mg/mL]false]Water]Insoluble]false Purity: 98.84%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
Rotation Report
SDS/MSDS
Datasheet

98.84

Related Targets	Adrenergic Receptor Estrogen/progestogen Receptor GPR Androgen Receptor Glucocorticoid Receptor ACE RAAS Progesterone Receptor Opioid Receptor THR
Other PGES Inhibitors	Yakuchinone A

Solubility

In vitro
Batch:

DMSO : 71 mg/mL (200.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 71 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.550mg/ml (10.01mM)	Taking the 1 mL working solution as an example, add 50 μL of 71 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.550mg/ml (10.01mM)	Taking the 1 mL working solution as an example, add 50 μL of 71 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	354.48	Formula	C₂₀H₃₄O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	745-65-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Prostaglandin-E1, Liprostin			SMILES	CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O

Read more about storage stability stock solution CAS number SMILES

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-12-15)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00610051	NOT_YET_RECRUITING	End Stage Cardiac Failure; HFrEF - Heart Failure With Reduced Ejection Fraction; NYHF Class III-IV	Biopeutics Co., Ltd	2026-10	PHASE3
NCT07604051	COMPLETED	Termination of Pregnancy	Dr Mudassar Saeed Pansota	2025-11-13	PHASE4
NCT03252626	UNKNOWN	Stroke	The First Hospital of Jilin University	2024-04-18	PHASE4
NCT06768177	ENROLLING_BY_INVITATION	Erectile Dysfunction Due to General Medical Condition; Erectile Dysfunction Following Radical Prostatectomy; Erectile Dysfunction Associated With Type 2 Diabetes Mellitus; Erectile Dysfunctions	Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari	2023-04-01
NCT05475717	TERMINATED	Contrast-induced Acute Kidney Injury	CSPC ZhongQi Pharmaceutical Technology Co., Ltd.	2022-10-20	PHASE2
NCT00610051	Not yet recruiting	Heart Failure	Biopeutics Co. Ltd	2023-10	Phase 3

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