Alprostadil

Licensed by Pfizer Catalog No.S1508 Synonyms: Prostaglandin-E1, PGE1, Edex, Muse, Liprostin

For research use only.

Alprostadil (Prostaglandin-E1, PGE1, Edex, Muse, Liprostin) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.

Alprostadil Chemical Structure

CAS No. 745-65-3

Purity & Quality Control

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Biological Activity

Description Alprostadil (Prostaglandin-E1, PGE1, Edex, Muse, Liprostin) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 71 mg/mL
(200.29 mM)
Water Insoluble
Ethanol '''71 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 354.48
Formula

C20H34O5

CAS No. 745-65-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00610051 Not yet recruiting Drug: Alprostadil Heart Failure Biopeutics Co. Ltd April 2022 Phase 3
NCT01776320 Withdrawn Drug: Alprostadil Erectile Dysfunction Lawson Health Research Institute December 2013 Phase 4
NCT02889822 Completed Drug: Alprostadil Liposomes for Injection Cardiovascular Diseases Guangzhou Yipinhong Pharmaceutical CO.LTD March 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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