Home Epigenetics Histone Methyltransferase inhibitor - Transferase inhibitor - HNMT inhibitor Amodiaquine dihydrochloride dihydrate For research use only.

Amodiaquine dihydrochloride dihydrate

Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.

Amodiaquine dihydrochloride dihydrate Chemical Structure

Amodiaquine dihydrochloride dihydrate Chemical Structure

CAS: 6398-98-7

Selleck's Amodiaquine dihydrochloride dihydrate has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.80%
99.80

Amodiaquine dihydrochloride dihydrate Related Products

Signaling Pathway

Histone Methyltransferase Signaling Pathways

Histone Methyltransferase Signaling Pathway

Choose Selective Histone Methyltransferase Inhibitors

Biological Activity

Description Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.
Targets
histamine N-methyl transferase [2]
(Cell-free assay)
18.6 nM(Ki)
In Vivo
In vivo In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs[3]. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation[1].
Animal Research Animal Models C57BL/6 mice
Dosages 2 and 5 mg/kg
Administration s.c.

Chemical Information & Solubility

Molecular Weight 464.81 Formula

C20H22ClN3O.2HCl.2H2O
CAS No. 6398-98-7 SDF Download Amodiaquine dihydrochloride dihydrate SDF
Smiles CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.O.O.Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 92 mg/mL ( (197.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 29 mg/mL

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Amodiaquine dihydrochloride dihydrate | Amodiaquine dihydrochloride dihydrate supplier | purchase Amodiaquine dihydrochloride dihydrate | Amodiaquine dihydrochloride dihydrate cost | Amodiaquine dihydrochloride dihydrate manufacturer | order Amodiaquine dihydrochloride dihydrate | Amodiaquine dihydrochloride dihydrate distributor