Almitrine mesylate

Catalog No.S4439 Synonyms: Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate

For research use only.

Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.

Almitrine mesylate Chemical Structure

CAS No. 29608-49-9

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Biological Activity

Description Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.
Targets
peripheral chemoreceptor [1] Ca2+-dependent K+ channel [2]
(Cell-free assay)
0.22 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 669.76
Formula

C28H37F2N7O6S2

CAS No. 29608-49-9
Storage 3 years -20°C powder
2 years -80°C in solvent

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