For research use only.
Licensed by Pfizer Catalog No.S4147
CAS No. 117772-70-0
Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.
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|Description||Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.|
Azithromycin displays a similar spectrum of antimicrobial activity. Azithromycin is marginally less active than erythromycin in vitro against Gram-positive organisms, although this is of doubtful clinical significance as susceptibility concentration fall within the range of achievable tissue Azithromycin concentrations. The mean MIC90 of Azithromycin against erythromycin susceptible/βL-ve strains, Streptococcus strains and NS (not selected for antimicrobial sesitivity)/erythromycin susceptible strains is 0.63, 0.35, and <0.27 mg/L, respectively. In contrast, Azithromycin appears to be more active than erythromycin against many Gram-negative pathogens and several other pathogens, notably Haemophilus influenza (MIC90, 1.34 mg/L), H. parainfluenzae(MIC90, 1 mg/L), Moraxella catarrhalis (MIC90, <0.1 mg/L), Neisseria gonorrhoeae (MIC90, 0.25 mg/L), Ureaplasma urealyticum, Bordetella spp (MIC90, 0.03-0.24 mg/L) and Borrelia burgdorferi. Azithromycin is also activity against clinical isolates of anaerobic bacteria Gram-positive cocci and propionibacterium acnes with MIC90 of 2.3, 0.03 mg/L. Like erythromycin and other macromycin, the activity of Azithromycin is unaffected by the production of β-lactamase. However, erythromycin-resistant organisms are also resistant to Azithromycin. 
|In vitro||DMSO||100 mg/mL (127.38 mM)|
|Ethanol||100 mg/mL (127.38 mM)|
|Water||10 mg/mL (12.73 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04269434||Not yet recruiting||Other: No Screening||Neisseria Gonorrhoeae Infection|Chlamydia Trachomatis Infection||Institute of Tropical Medicine Belgium||September 2020||Not Applicable|
|NCT04424511||Not yet recruiting||Drug: Placebo|Drug: Azithromycin||Mortality||Tampere University|Center for Vaccine Development CVD-Mali Bamako Mali|University College London UK.|Tro Da Ltd UK|Duke-NUS Graduate Medical School|Bill and Melinda Gates Foundation (Funder)|Pfizer Inc. (Provider of study drugs)||August 2020||Phase 3|
|NCT04326478||Not yet recruiting||Drug: Azithromycin||Cholera||Massachusetts General Hospital|International Centre for Diarrhoeal Disease Research Bangladesh||July 2020||Phase 2|
|NCT04462367||Not yet recruiting||--||COVID19|Coronavirus Infection|Pregnancy Disease|Severe Acute Respiratory Syndrome||Instituto Materno Infantil Prof. Fernando Figueira||July 1 2020||--|
|NCT04358081||Recruiting||Drug: HCQ|Drug: HCQ+AZT|Drug: Placebo||Covid-19||Novartis Pharmaceuticals|Novartis||May 1 2020||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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