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Alendronic Acid

Name: Alendronic Acid
Brand: Selleck Chemicals
SKU: S5536
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S5536

Alendronic acid (alendronate) is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.

Chemical Structure

Molecular Weight: 249.10

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Quality Control

Batch: S553601 0.5MNAOH]6.05 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 98%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

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Solubility

In vitro
Batch:

0.5MNAOH : 6.05 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	249.10	Formula	C₄H₁₃NO₇P₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	66376-36-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	alendronate			Smiles	C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05645289	Not yet recruiting	Postmenopausal Osteoporosis	Peking University Third Hospital	January 1 2023	Phase 4
NCT03051620	Completed	Osteoporosis	Aarhus University Hospital\|University of Aarhus	February 1 2017	--
NCT02781805	Terminated	Breast Neoplasms	University of Wisconsin Madison\|Wisconsin Partnership Program	August 5 2016	Phase 1

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Handling Instructions

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