Alendronic Acid

Catalog No.S5536 Synonyms: alendronate

For research use only.

Alendronic acid (alendronate) is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.

Alendronic Acid Chemical Structure

CAS No. 66376-36-1

Purity & Quality Control

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Biological Activity

Description Alendronic acid (alendronate) is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 249.10
Formula

C4H13NO7P2

CAS No. 66376-36-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03051620 Completed Drug: Discontinue alendronate Osteoporosis Aarhus University Hospital|University of Aarhus February 1 2017 --
NCT02781805 Terminated Drug: Alendronate Breast Neoplasms University of Wisconsin Madison|Wisconsin Partnership Program August 5 2016 Phase 1
NCT01526278 Completed Drug: Maxmarvil® Osteoporosis Yuyu Pharma Inc. October 2011 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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