A-1331852

Catalog No.S7801

A-1331852 Chemical Structure

Molecular Weight(MW): 658.81

A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.

Size Price Stock Quantity  
USD 197 In stock
USD 697 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 7 Publications

2 Customer Reviews

  • Cells were treated with 0.5 μM A-1331852 and 1.5 nM VCR (RD), 0.5 nM VCR (RH30) for 72 h. Apoptosis was determined by analysis of DNA fragmentation of PI-stained nuclei using flow cytometry. Mean and SD of three independent experiments performed in triplicate are shown; **P < 0.01.

    Cancer Lett, 2018, 412:131-142. A-1331852 purchased from Selleck.

    Enhanced induction of synergistic apoptosis with A-1331852 over navitoclax and not venetoclax in PC-3 cells (A) confirming the specificity for BCL-XL inhibition and potency of A-1331852.

    Mol Cancer Res, 2016, 14(12):1176-1181. A-1331852 purchased from Selleck.

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.
Targets
Bcl-xL [1]
(Cell-free assay)
<0.01 nM(Ki)
In vitro

A-1331852 exhibits remarkable potency both as a single agent and in combination with TKIs in killing primary CD34+ CML cell. Also, It has remarkable potency in inducing apoptosis in these cells at low nanomolar concentrations as early as 1 h post-treatment[2].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEL cells  NGDlWFdCeG:ydH;zbZMh[XO|YYm= MmnpOFghcA>? MUjpcoR2[2ViYYDvdJRwe2m|IIP5coVz\2m|dHnjZYxtgSC5aYToJJJ2gG:uaYTpcoljKGmwIFjFUEBk\Wyucx?= MVWyPVkzQDR6OB?=
H1299 cells MWrBdI9xfG:|aYOgZZN{[Xl? NHnEWnAyODBibl2= NHzxXG5iKGOxbXLpcoF1cW:wIH;mJGEuOTJzMES3O{BidmRiQT2xN|MyQDV{IILld5VtfGWmIHnuJIEhdWG{a3XkJIlv\HWldHnvckBw\iCjcH;weI9{cXN? MlLiNlgxPzl6OEe=
CLL MXPBdI9xfG:|aYOgZZN{[Xl? M1vqPVQhcA>? MVTpcpNmdnOrdHn2[UB1dyCDLUGzN|E5PTJuIFnDOVA:OS5zIN88US=> M122XVI3QTV2N{G4
MOLT-4 MU\BdI9xfG:|aYOgZZN{[Xl? NYPVfVlVPCCq NVHjWW1Xe2Wwc3n0bZZmKHSxIFGtNVM{OTh3MjygTWM2OH54Lkegcm0> MknpNlY6PTR5MUi=
H929 MWLBdI9xfG:|aYOgZZN{[Xl? M2fsS|QhcA>? NG\5cHZqdnOnboPpeIl3\SC2bzDBMVE{OzF6NUK= NXrsUHBkOjZ7NUS3NVg>
H1299 NWWx[Jo2SXCxcITvd4l{KGG|c3H5 M3ewbFQhcA>? M2OyTIlve2Wwc3n0bZZmKHSxIFGtNVM{OTh3Mh?= Mn3CNlY6PTR5MUi=
K562 NVjRUoZiSXCxcITvd4l{KGG|c3H5 MoDtNlQhcA>? M4i4bYV5fHKnbXXsfUBxd3SnboSgbY4hcW6mdXPpcoch[XCxcITvd4l{KGG2IHzve{Bv[W6xbX;sZZIh[2:wY3XueJJifGmxboO= MUCyOlk5PzlyNh?=
KCL22 MnHPRZBweHSxc3nzJIF{e2G7 NHrqcHAzPCCq NGDsVldmgHS{ZX3lcJkheG:2ZX70JIlvKGmwZIXjbY5oKGGyb4D0c5NqeyCjdDDsc5chdmGwb33vcIFzKGOxbnPlcpRz[XSrb37z M1z0elI3QTh5OUC2

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
BIM / Bad / Bcl-XL; 

PubMed: 26987906     


Immunoprecipitation of BCL-XL was carried out in K562 cells, exposed to A-1331852 (100 nm) for 0–2 h, and the eluted complexes were immunoblotted for the indicated proteins. The input cell lysates and the immunodepleted supernatant (labeled as Flow-through) were immunoblotted to check the efficiency of the immunoprecipitation. BC represents beads control. 

26987906
Growth inhibition assay
Cell viability; 

PubMed: 28273655     


A1331852 selectively reduces senescent but not proliferating HUVECs and IMR90 cell numbers (crystal violet). The red lines denote cell numbers at plating on day 0 of senescent and non-senescent cells, both set to 100%. HUVEC and IMR90 data are means±SEM of 5 replicates at each drug concentration. Preadipocyte data are means±SEM of 5 replicates from each of 4 different subjects at each concentration.

28273655
In vivo A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a single agent[1].

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: K562 cells
  • Concentrations: 100 nM
  • Incubation Time: 0-2 h
  • Method: Immunoprecipitation of BCL-XL is carried out in K562 cells, exposed to A-1331852 (100 nM) for 0-2 h, and the eluted complexes are immunoblotted for the indicated proteins. The input cell lysates and the immunodepleted supernatant (labeled as Flow-through) are immunoblotted to check the efficiency of the immunoprecipitation.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: SCID and SCID-bg mice
  • Formulation: 60% Phosal 50 PG, 27.5 % PEG 400, 10% ethanol, and 2.5% DMSO
  • Dosages: 25 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (151.78 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 658.81
Formula

C38H38N6O3S

CAS No. 1430844-80-6
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Bcl-2 Signaling Pathway Map

Related Bcl-2 Products

Tags: buy A-1331852 | A-1331852 supplier | purchase A-1331852 | A-1331852 cost | A-1331852 manufacturer | order A-1331852 | A-1331852 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID