AZD0156

For research use only.

Catalog No.S8375

10 publications

AZD0156 Chemical Structure

CAS No. 1821428-35-6

AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells.

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Selleck's AZD0156 has been cited by 10 publications

Purity & Quality Control

Choose Selective ATM/ATR Inhibitors

Biological Activity

Description AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells.
Targets
ATM [1]
In vitro

AZD0156 shows sub-nanomolar potency in cell based assays of ATM inhibition with selectivities of greater than 1000 fold over other members of the PIKK family of enzymes[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HT29 MYTGeY5kfGmxbjDhd5NigQ>? MlnwNUBpeg>? NIDSdWVKdmirYnn0bY9vKG:oIFHUUUBifXSxcHjvd5Bpd3K7bHH0bY9vKGG2IGPldlE6QDFiaX6gbJVu[W5iSGSyPUBk\WyuczDwdoVqdmO3YnH0[YQh\m:{IEGgbJIh\m:ubH;3[YQh[nliWDDyZZkhcXK{YXTpZZRqd25iYX7kJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nliSH;lZ4h{fCB|M{O0NkBlgWVvYnHz[YQhcW2vdX7v[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyPUCuNFAxPTgQvF2= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6M{[1PUc,Ojl4OEO2OVk9N2F-
PC3 NH3zdYVHfW6ldHnvckBie3OjeR?= MXexNFAhdWdxa3e= NIDTeXE5KGi{cx?= MnLWTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejR5MzDpckBRXEWQLXTl[olkcWWwdDDoeY1idiCSQ{OgZ4VtdHNieHXuc4dz[W[2IH3veZNmKG2xZHXsJIF1KDFyMDDt[{9s\yxicH:gd4lv\2ynIHTvd4UhdWWjc4Xy[YQhfXBidH:gPEBpenN? M2TJTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkizOlU6Lz5{OU[4N|Y2QTxxYU6=
PC3 NIP0XFNCdnSrdIXtc5Ih[XO|YYm= NVi2c3VWOzBibXevb4c> Mk\wRY51cXS3bX;yJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IIjlco9oemGodDDtc5V{\SCvb3TlcEBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJR2dW:{IHfyc5d1cCCjdDCzNEBu\y:tZzygdI8h[mmmIHnuJJBz\XOnbnPlJI9nKDFvYX3pco9j\W68b4TybYF7d2yn NUXHS2kyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2PFM3PTlpPkK5Olg{PjV7PD;hQi=>
HT29 MoPvSpVv[3Srb36gZZN{[Xl? MWqxJIhz NWHOem5tUW6qaXLpeIlwdiCxZjDBWHIhcW5iaIXtZY4hUFR{OTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBEcGtzIIDoc5NxcG:{eXzheIlwdiCjdDDT[ZIhOzR3IIDy[Ylv[3WkYYTl[EBnd3JiMTDodkBnd2yub4fl[EBjgSB2TmHPJIFl\Gm2aX;uJIFv\CCvZXHzeZJm\CCjZoTldkAyKGi{IHL5JGhw\WOqc4SgN|M{PDJiZInlMYJie2WmIHntcZVvd2[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NF03NjMQvF2= NHr2T3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[4N|Y2QSd-Mkm2PFM3PTl:L3G+
SW620 NX3odnd1TnWwY4Tpc44h[XO|YYm= M2WzblIxKG2pL3vn MWnQc5RmdnSrYYTpc44hd2ZiaYLpco91\WOjbj3pcoR2[2WmIIT1cY9zKHKnZ4Lld5Nqd25iYXfhbY5{fCCqdX3hckBUXzZ{MDDj[YxteyC6ZX7v[5Ji\nSnZDDpckBqdW23bn;jc41xem:vaYPl[EBud3W|ZTDheEAzOCCvZz;r[{wheG9icXSgZYRucW6rc4TldoVlKG:wIHThfZMhOiC2bzC0JI9nKHenZXvsfUBkgWOuZR?= MnLCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4OEO2OVkoRjJ7NkizOlU6RC:jPh?=
HBCx-10 MkDnSpVv[3Srb36gZZN{[Xl? MVW1JI1oN2up MnTFVI91\W62aXH0bY9vKG:oIHnybY5wfGWlYX6tbY5lfWOnZDD0eY1weiC{ZXfy[ZN{cW:wIHHnZYlve3RiaIXtZY4hUEKFeD2xNEBk\WyuczD4[Y5w\3KjZoTl[EBqdiCrbX31co9kd22ycn;tbZNm\CCvb4Xz[UBifCB3IH3nM4toNCCybzDx[EBi\G2rbnnzeIVz\WRib36g[IF6eyBzIITvJFMhd2Zid3Xlb4x6KGO7Y3zl MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6M{[1PUc,Ojl4OEO2OVk9N2F-
HT29 MXnGeY5kfGmxbjDhd5NigQ>? M3XqVmNmdGy3bHHyJGF{e2G7OjDBd5NigSCjKTDIWFI6KGOnbHzzJEhGS0GFQzCjPFUxPjFzMEmpJJdmemVic3Xl[IVlKGmwdH:gN|g1KHenbHygZZN{[XlicHzheIV{KCiFb4P0ZZIhKzN5MUKpJIF1KGFiZHXud4l1gSCxZjCzOVAxKGOnbHzzM5dmdGxiaX6gOFAh|ryuIFXNSW0hdWWmaYXtJINwdnSjaX7pcochOSViTDDncJV1[W2rbnWgZY5lKDFyJTDGRnMh[W6mIHHscI94\WRidH:gZYRp\XKnIH;2[ZJvcWeqdD6gWIhmKG[xbHzve4lv\yCvb4LubY5oKGNuIFnDOVA:OC5yMEC1O|XPxE1? NU\1WHo6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ7N{i5PU8oRkOqRV3CUFww[T5?
MDA-MB-468 MonBSpVv[3Srb36gZZN{[Xl? MUTD[YxtfWyjcjDBd5NigTpiQYPzZZkh\CliTVTBMW1DNTR4ODDj[YxteyBqaIXtZY4h[nKnYYP0JIFl\W6xY3HyZ4lvd22jIDOjRXRESyCKVFKgNVMzMSC5ZYLlJJNm\WSnZDDheEAyPTByIHPlcIx{N3enbHygbY4hPDBizszsJI9nKESPRV2gZ49vfGGrbnnu[{AyOCViRlLTJIFv\CBzJTDncJV1[W2rbnWgbY51dyCJcnXpcoVzKDN6NDD3[YxtKGKuYXPrJIZt[XRvYn;0eI9u\WRicHzheIV{NCCLQ{WwQVAvPjIQvF2= M1TB[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQzQTd6OUmvK|5EcEWPQly8M4E,
PC3 NUK5OW5nSW62aYT1cY9zKGG|c3H5 NGnVbJM3OCCvZz;r[y=> MV;BcpRqfHWvb4KgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNieHXuc4dz[W[2IH3veZNmKG2xZHXsJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geJVud3JiZ4Lve5RpKGG2IE[wJI1oN2upLDDwc{BjcWRiaX6gdJJme2WwY3Wgc4YhOS2jbXnuc4JmdnqxdILpZZpwdGV? NWrodldZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ7N{i5PU8oRkOqRV3CUFww[T5?
HT29 M1KyRmZ2dmO2aX;uJIF{e2G7 NYrpSlFwS2WubIXsZZIhSXO|YYm6JGF{e2G7IHKpJGhVOjliY3XscJMhMEWFQVPDJEM5PTB4MUGwPUkhf2W{ZTDz[YVl\WRiaX70c{A{QDRid3XscEBie3OjeTDwcIF1\XNiKFPvd5RieiBlM{exNkkh[XRiYTDk[Y5{cXS7IH;mJFYxODBiY3XscJMwf2WubDDpckA1OCEQvHygSW1GVSCvZXTpeY0h[2:wdHHpcolv\yBzJTDMJIdtfXSjbXnu[UBidmRiMUClJGZDWyCjbnSgZYxtd3enZDD0c{Bi\GincnWgc5Zmem6rZ3j0MEBKSzVyPU[uNVbPxE1? NYPH[G1LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ7N{i5PU8oRkOqRV3CUFww[T5?

... Click to View More Cell Line Experimental Data

In vivo AZD0156 is a permeable, highly soluble compound with excellent preclinical pharmacokinetic properties including oral bioavailability. AZD0156 shows robust efficacy in mouse xenograft models after oral administration when combined with DSB inducing agents. AZD0156 is currently undergoing early clinical assessment[1].

Protocol

Solubility (25°C)

In vitro Ethanol 2 mg/mL (4.33 mM)
DMSO 0.3 mg/mL warmed (0.64 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.56
Formula

C26H31N5O3

CAS No. 1821428-35-6
Storage powder
in solvent
Synonyms N/A
Smiles CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4CCOCC4)C5=CN=C(C=C5)OCCCN(C)C

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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ATM/ATR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID