AZD0156

Catalog No.S8375

For research use only.

AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells.

AZD0156 Chemical Structure

CAS No. 1821428-35-6

Selleck's AZD0156 has been cited by 14 publications

Purity & Quality Control

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Biological Activity

Description AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells.
Targets
ATM [1]
In vitro

AZD0156 shows sub-nanomolar potency in cell based assays of ATM inhibition with selectivities of greater than 1000 fold over other members of the PIKK family of enzymes[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HT29 NFXiPJlHfW6ldHnvckBie3OjeR?= M2j1VFEhcHJ? M3n4UmlvcGmkaYTpc44hd2ZiQWTNJIF2fG:yaH;zdIhwenmuYYTpc44h[XRiU3XyNVk5OSCrbjDoeY1idiCKVEK5JINmdGy|IIDy[Ylv[3WkYYTl[EBnd3JiMTDodkBnd2yub4fl[EBjgSC[IILhfUBqenKjZHnheIlwdiCjbnSgcYVie3W{ZXSgZYZ1\XJiMTDodkBjgSCKb3XjbJN1KDN|M{SyJIR6\S2kYYPl[EBqdW23bn;mcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTB;MD6wNFA2P87:TR?= MoC2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl4OEO2OVkoRjJ7NkizOlU6RC:jPh?=
PC3 MWLGeY5kfGmxbjDhd5NigQ>? NVPEN5dvOTByIH3nM4to NGi2fGg5KGi{cx?= NWC5W29CUW6qaXLpeIlwdiCxZjDBb5QheGixc4Doc5J6dGG2aX;uJIF1KFOnckS3N{BqdiCSVFXOMYRm\mmlaXXueEBpfW2jbjDQR|Mh[2WubIOgfIVvd2e{YX\0JI1wfXOnIH3v[IVtKGG2IEGwNEBu\y:tZzygdI8he2mwZ3zlJIRwe2VibXXhd5Vz\WRidYCgeI8hQCCqcoO= NW\EVnJ2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2PFM3PTlpPkK5Olg{PjV7PD;hQi=>
PC3 NILoW|ZCdnSrdIXtc5Ih[XO|YYm= Mn[zN|AhdWdxa3e= NX\acZFoSW62aYT1cY9zKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gVGM{KGOnbHzzJJhmdm:pcnHmeEBud3W|ZTDtc4RmdCCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHS3bX;yJIdzd3e2aDDheEA{OCCvZz;r[{wheG9iYnnkJIlvKHC{ZYPlcoNmKG:oIEGtZY1qdm:kZX76c5RzcWG8b3zl NHntOYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[4N|Y2QSd-Mkm2PFM3PTl:L3G+
HT29 MX\GeY5kfGmxbjDhd5NigQ>? NWTKNmU1OSCqch?= MUPJcohq[mm2aX;uJI9nKEGWUjDpckBpfW2jbjDIWFI6KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFPob|EheGixc4Doc5J6dGG2aX;uJIF1KFOncjCzOFUheHKnaX7jeYJifGWmIH\vdkAyKGi{IH\vcIxwf2WmIHL5JFRPWU9iYXTkbZRqd25iYX7kJI1m[XO3cnXkJIFnfGW{IEGgbJIh[nliSH;lZ4h{fCB|M{O0NkBlgWVvYnHz[YQhcW2vdX7v[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyPU[uNu69VQ>? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6M{[1PUc,Ojl4OEO2OVk9N2F-
SW620 NGH6U|FHfW6ldHnvckBie3OjeR?= NELXfJMzOCCvZz;r[y=> MVrQc5RmdnSrYYTpc44hd2ZiaYLpco91\WOjbj3pcoR2[2WmIIT1cY9zKHKnZ4Lld5Nqd25iYXfhbY5{fCCqdX3hckBUXzZ{MDDj[YxteyC6ZX7v[5Ji\nSnZDDpckBqdW23bn;jc41xem:vaYPl[EBud3W|ZTDheEAzOCCvZz;r[{wheG9icXSgZYRucW6rc4TldoVlKG:wIHThfZMhOiC2bzC0JI9nKHenZXvsfUBkgWOuZR?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6M{[1PUc,Ojl4OEO2OVk9N2F-
HBCx-10 NVr1NGltTnWwY4Tpc44h[XO|YYm= NWXmNYZOPSCvZz;r[y=> NWDLPZB6WG:2ZX70bYF1cW:wIH;mJIlzcW6xdHXjZY4ucW6mdXPl[EB1fW2xcjDy[Ydz\XO|aX;uJIFo[Wmwc4SgbJVu[W5iSFLDfE0yOCClZXzsd{B5\W6xZ4Lh[pRm\CCrbjDpcY12dm:lb33wdo9ucXOnZDDtc5V{\SCjdDC1JI1oN2upLDDwc{By\CCjZH3pcol{fGW{ZXSgc44h\GG7czCxJJRwKDNib3[ge4Vmc2y7IHP5Z4xm MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ6M{[1PUc,Ojl4OEO2OVk9N2F-
HT29 NIn6fGZHfW6ldHnvckBie3OjeR?= NYDuflZ5S2WubIXsZZIhSXO|YYm6JGF{e2G7IHGpJGhVOjliY3XscJMhMEWFQVPDJEM5PTB4MUGwPUkhf2W{ZTDz[YVl\WRiaX70c{A{QDRid3XscEBie3OjeTDwcIF1\XNiKFPvd5RieiBlM{exNkkh[XRiYTDk[Y5{cXS7IH;mJFM2ODBiY3XscJMwf2WubDDpckA1OCEQvHygSW1GVSCvZXTpeY0h[2:wdHHpcolv\yBzJTDMJIdtfXSjbXnu[UBidmRiMUClJGZDWyCjbnSgZYxtd3enZDD0c{Bi\GincnWgc5Zmem6rZ3j0MkBVcGViZn;scI94cW6pIH3vdo5qdmdiYzygTWM2OD1yLkCwNFU4Pc7:TR?= NWnHRZBTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDJ7N{i5PU8oRkOqRV3CUFww[T5?
MDA-MB-468 MXnGeY5kfGmxbjDhd5NigQ>? MYXD[YxtfWyjcjDBd5NigTpiQYPzZZkh\CliTVTBMW1DNTR4ODDj[YxteyBqaIXtZY4h[nKnYYP0JIFl\W6xY3HyZ4lvd22jIDOjRXRESyCKVFKgNVMzMSC5ZYLlJJNm\WSnZDDheEAyPTByIHPlcIx{N3enbHygbY4hPDBizszsJI9nKESPRV2gZ49vfGGrbnnu[{AyOCViRlLTJIFv\CBzJTDncJV1[W2rbnWgbY51dyCJcnXpcoVzKDN6NDD3[YxtKGKuYXPrJIZt[XRvYn;0eI9u\WRicHzheIV{NCCLQ{WwQVAvPjIQvF2= MkjLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI6Pzh7OT:nQmNpTU2ETEyvZV4>
PC3 MX7BcpRqfHWvb4KgZZN{[Xl? NEjZPYw3OCCvZz;r[y=> M2nPXmFvfGm2dX3vdkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczD4[Y5w\3KjZoSgcY92e2VibX;k[Ywh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB1fW2xcjDndo94fGhiYYSgOlAhdWdxa3esJJBwKGKrZDDpckBxemW|ZX7j[UBw\iBzLXHtbY5w[mWwen;0doligm:uZR?= NHq2T|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1Ojl5OEm5M{c,S2iHTVLMQE9iRg>?
HT29 M3;tdGZ2dmO2aX;uJIF{e2G7 M{Hod2NmdGy3bHHyJGF{e2G7OjDBd5NigSCkKTDIWFI6KGOnbHzzJEhGS0GFQzCjPFUxPjFzMEmpJJdmemVic3Xl[IVlKGmwdH:gN|g1KHenbHygZZN{[XlicHzheIV{KCiFb4P0ZZIhKzN5MUKpJIF1KGFiZHXud4l1gSCxZjC2NFAxKGOnbHzzM5dmdGxiaX6gOFAh|ryuIFXNSW0hdWWmaYXtJINwdnSjaX7pcochOSViTDDncJV1[W2rbnWgZY5lKDFyJTDGRnMh[W6mIHHscI94\WRidH:gZYRp\XKnIH;2[ZJvcWeqdDygTWM2OD14LkG2{txO MliyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFI6Pzh7OT:nQmNpTU2ETEyvZV4>
In vivo AZD0156 is a permeable, highly soluble compound with excellent preclinical pharmacokinetic properties including oral bioavailability. AZD0156 shows robust efficacy in mouse xenograft models after oral administration when combined with DSB inducing agents. AZD0156 is currently undergoing early clinical assessment[1].

Protocol (from reference)

Solubility (25°C)

In vitro

Ethanol 2 mg/mL
(4.33 mM)
DMSO 0.3 mg/mL warmed
(0.64 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.56
Formula

C26H31N5O3

CAS No. 1821428-35-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4CCOCC4)C5=CN=C(C=C5)OCCCN(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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