Ampicillin Trihydrate

Catalog No.S4148 Synonyms: NCI-C56086

Ampicillin Trihydrate Chemical Structure

Molecular Weight(MW): 403.45

Ampicillin Trihydrate is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

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Biological Activity

Description Ampicillin Trihydrate is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.
Features More effective than levofloxacin and ciprofloxacin against Streptococcus pneumoniae.
Targets
beta-lactamase [1]
In vitro

Ampicillin Trihydrate (500 mg) results in rapid bactericidal effect for SP34, the concentrations declines to the limit of detection (100 CFU/mL) during the initial 6 hours, and regrowth is not observed over the remaining 18 hours. [1]

In vivo Ampicillin Trihydrate (10 mg/kg) results in half life (t 1/2) of 1.2 hours in goats and 2.48 hours in sheep, clearance (Cl) of 2921 mL/h·kg in goats and 262 mL/h·kg in sheep, ampicillin volume of distribution (Vdarea) of 5673 mL/kg in goats and 992 mL/kg in sheep. [2] Ampicillin Trihydrate (0.18 kg/kg-3 kg/kg) results in no dose-related mortality, normal body weights, no compound-related gross or histopathologic lesions and diarrhea in mice and rats. [3] Ampicillin in combination of norfloxacin, at a dose of 1g/L, maximally suppresses the numbers of cecal aerobic and anaerobic bacteria in ob/ob mice. Ampicillin in combination of norfloxacin results in a significant improvement in fasting glycemia and oral glucose tolerance reduced liver triglycerides and increased liver glycogen and concomitant reduction of plasma lipopolysaccharides in ob/ob mice. [4] Ampicillin trihydrate (20 mg/kg) treats five foals, the mean peak serum ampicillin concentration at two to three days old is 5.0 μg/mL at 1 hours after treatment, the mean peak serum concentration at 16 days to 21 days old is 2.7 μg/mL at 2 hours, the concentrations steadily declines and ampicillin is not detected in the serum from any of the foals by 24 hours, and serum clearance averages 17.7 mL/min/kg at two to three days and 35.8 mL/min/kg at 16 days to 21 days. [5]

Protocol

Solubility (25°C)

In vitro DMSO 81 mg/mL (200.76 mM)
Water 2 mg/mL (4.95 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 403.45
Formula

C16H19N3O4S.3H2O

CAS No. 7177-48-2
Storage powder
in solvent
Synonyms NCI-C56086

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03129620 Completed -- Hypothermia Drexel University March 2013 --
NCT01433757 Completed Drug: Ampicillin|Drug: Sugar pill DYT-1|Dystonia University of Florida|Tyler''s Hope for a Dystonia Cure Inc September 2011 Phase 1
NCT01118403 Withdrawn Drug: Sultamicillin Ventilator Associated Pneumonia Hospital Pablo Tobón Uribe March 2011 Phase 4
NCT00137007 Completed Drug: Azithromycin|Drug: Ampicillin/sulbactam Pneumonia Pfizer November 2003 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID