4-Aminopyridine

Catalog No.S5028 Synonyms: fampridine, dalfampridine

4-Aminopyridine Chemical Structure

Molecular Weight(MW): 94.11

4-Aminopyridine (4-AP) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.

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Biological Activity

Description 4-Aminopyridine (4-AP) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.
Targets
Kv1.4 [2]
()
Kv3.1 [2]
()
Kv3.2 [2]
()
Kv1.3 [2]
()
Kv1.1 [2]
()
13 μM 29 μM 100 μM 195 μM 290 μM
In vitro

Working from the intracellular side of the channel, 4-AP inhibits a wide variety of voltage-dependent K+ channels with affinities ranging from the mid-micromolar to the millimolar range[1].

Protocol

Solubility (25°C)

In vitro DMSO 18 mg/mL (191.26 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 94.11
Formula

C5H6N2

CAS No. 504-24-5
Storage powder
in solvent
Synonyms fampridine, dalfampridine

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02868567 Recruiting Drug: dalfampridine Motor Neuron Disease Upper Weill Medical College of Cornell University|Hospital for Special Surgery New York March 2016 Phase 1
NCT02422940 Terminated Drug: dalfampridine-ER 7.5 mg|Drug: dalfampridine-ER 10 mg Post-ischemic Stroke Acorda Therapeutics April 2015 Phase 3
NCT02208882 Completed Drug: BMS-986120|Drug: Placebo|Drug: Midazolam Healthy Adult Volunteers Bristol-Myers Squibb August 2014 Phase 1
NCT02208050 Completed Drug: Fampridine|Drug: Placebo Secondary Progressive Multiple Sclerosis|Primary Progressive Multiple Sclerosis University College Dublin March 2014 Phase 4
NCT01576354 Unknown status Drug: Prolonged-release Fampridine|Drug: Placebo Multiple Sclerosis University of Zurich March 2012 Phase 2

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Potassium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID