Home Transmembrane Transporters Potassium Channel inhibitor 4-Aminopyridine

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4-Aminopyridine Potassium Channel inhibitor

Cat.No.S5028

4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
4-Aminopyridine Potassium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 94.11

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Quality Control

Batch: S502801 DMSO]18 mg/mL]false]]]false]]]false Purity: 99.99%
99.99

Solubility

In vitro
Batch:

DMSO : 18 mg/mL (191.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 94.11 Formula

C5H6N2

 Storage (From the date of receipt)
CAS No. 504-24-5 -- Storage of Stock Solutions

Synonyms Fampridine, Dalfampridine Smiles C1=CN=CC=C1N

Mechanism of Action

Targets/IC50/Ki
Kv1.4
13 μM
Kv3.1
29 μM
Kv3.2
100 μM
Kv1.3
195 μM
Kv1.1
290 μM
Kv1.2
590 μM
In vitro
Working from the intracellular side of the channel, 4-AP inhibits a wide variety of voltage-dependent K+ channels with affinities ranging from the mid-micromolar to the millimolar range.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06333171 Not yet recruiting
Wounds|Wound of Skin|Wound Heal|Wounds and Injuries
John Elfar|University of Arizona
 July 2024 Phase 2
NCT05338450 Recruiting
Multiple Sclerosis|Internuclear Ophthalmoplegia
Amsterdam UMC location VUmc
 August 30 2022 Phase 3
NCT02868567 Active not recruiting
Motor Neuron Disease Upper
Hospital for Special Surgery New York
 March 2016 Phase 1
NCT02422940 Terminated
Post-ischemic Stroke
Acorda Therapeutics
 April 2015 Phase 3
NCT02208882 Completed
Healthy Adult Volunteers
Bristol-Myers Squibb
 August 2014 Phase 1
NCT02208050 Completed
Secondary Progressive Multiple Sclerosis|Primary Progressive Multiple Sclerosis
University College Dublin
 February 21 2014 Phase 4

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