Catalog No.S5028 Synonyms: fampridine, dalfampridine
Molecular Weight(MW): 94.11
4-Aminopyridine (4-AP) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.
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|Description||4-Aminopyridine (4-AP) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.|
Working from the intracellular side of the channel, 4-AP inhibits a wide variety of voltage-dependent K+ channels with affinities ranging from the mid-micromolar to the millimolar range.
|In vitro||DMSO||18 mg/mL (191.26 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02868567||Recruiting||Drug: dalfampridine||Motor Neuron Disease Upper||Weill Medical College of Cornell University|Hospital for Special Surgery New York||March 2016||Phase 1|
|NCT02422940||Terminated||Drug: dalfampridine-ER 7.5 mg|Drug: dalfampridine-ER 10 mg||Post-ischemic Stroke||Acorda Therapeutics||April 2015||Phase 3|
|NCT02208882||Completed||Drug: BMS-986120|Drug: Placebo|Drug: Midazolam||Healthy Adult Volunteers||Bristol-Myers Squibb||August 2014||Phase 1|
|NCT02208050||Completed||Drug: Fampridine|Drug: Placebo||Secondary Progressive Multiple Sclerosis|Primary Progressive Multiple Sclerosis||University College Dublin||March 2014||Phase 4|
|NCT01576354||Unknown status||Drug: Prolonged-release Fampridine|Drug: Placebo||Multiple Sclerosis||University of Zurich||March 2012||Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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