Apabetalone (RVX-208)

For research use only.

Catalog No.S7295 Synonyms: RVX-000222

14 publications

Apabetalone (RVX-208) Chemical Structure

CAS No. 1044870-39-4

Apabetalone (RVX-208, RVX-000222) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.

Selleck's Apabetalone (RVX-208) has been cited by 14 publications

3 Customer Reviews

  • Bromodomain 1 or 2 of BET family proteins is involved in 3T3-L1 adipogenesis. (A) LY294002, RVX208 and JQ1 were applied to differentiating 3T3-L1 from day 2 to day 6. Phenyl acetate (PA), known as a PPAR-γ agonist was used as a positive control. Cells were labeled with ORO (Bar=50nm). (B) Schematic representation of specificity of each chemical inhibitor for Bromodomain BD1 and 2 and quantitative analysis of ORO staining. The IDMR treatment without drugs (CTL) was used to define 100%. Data are reported as means ± sd (n=3); *** p<0.001 vs IDM control; ### p<0.001 vs IDMR control (-)-JQ1); +++ p<0.01 vs IDM of each condition; ns, non significant.

    BBRC, 2016, 472(4):624-630.. Apabetalone (RVX-208) purchased from Selleck.

  • Effect of Bromodomain inhibitors on Ad infection. A549 cells were mock-treated (0.1% DMSO in culture medium) or treated with RVX-208 at 500 nM, PFI-1 at 500 nM, JQ1 at 300 nM, or with 300 nM (−)-JQ1, an inactive enantiomer of JQ1. The cells were then infected with Ad2 at 1 PFU/cell for 24 h. The compounds were left in the culture medium throughout the infection. Viral hexon and penton base (PB) protein was detected by immunoblotting analysis. GADPH expression was used as a loading control. The experiment was performed 3 times independently.

    Sci Rep, 2018, 8(1):11554. Apabetalone (RVX-208) purchased from Selleck.

  • Apabetalone increased cyclin T1 expression and induced CDK9 T-loop and RNAP II CTD phosphorylation in ACH2 cells in time-dependent manners.

    Acta Pharmacol Sin, 2018, doi:10.1038/s41401-018-0027-5. Apabetalone (RVX-208) purchased from Selleck.

Purity & Quality Control

Choose Selective Epigenetic Reader Domain Inhibitors

Biological Activity

Description Apabetalone (RVX-208, RVX-000222) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.
Features First-in-class BD2-selective inhibitor of BET bromodomain and has been tested in Phase II clinical trials for treatment of coronary syndromes and atherosclerosis.
Targets
BD2 [1]
(Cell-free assay)
0.51 μM
In vitro

As a BET bromodomain inhibitor, RVX-208 preferentially binds to the second bromodomain found on BET proteins. [1] RVX-208, as a stimulator of apolipoprotein (APO) AI gene expression, increases apoA-I and HDL-C in vitro. [2] [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 NEHJd4xHfW6ldHnvckBie3OjeR?= MVf+OlAh|ryP M1XzO2ROW09? NGXjW3RqdmS3Y3XzJIFxd0FvSTDtVm5CKGGwZDDk[UBvd3[xIIP5cpRp\XOrczDv[kBieG:DLVmu NYHPc404RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC1NVM2QTlpPkKwOVE{PTl7PD;hQi=>
U2OS MYfGeY5kfGmxbjDhd5NigQ>? M{Hadp42KM7:TR?= NHryS4ZlcXOybHHj[ZMhSkWWIIDyc5RmcW6|IH\yc40h[2i{b33heIlv MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ2OEO3PUc,OjR{NEizO|k9N2F-
BL21(DE3)-R3-pRARE2 NXjwW5BkTnWwY4Tpc44h[XO|YYm= NG\O[5NKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFjpd|YufGGpZ3XkJGJTTDRiYoLvcY9ld22jaX6gNkBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxLGRGOylvUkOtdHJCWkV{IHPlcIx{KHC{ZXnuZ5Vj[XSnZDDmc5IhOzBibXnud{Bnd2yub4fl[EBjgSCKU1fSS2spSWNrR1fLLGFkMUeOR1uoRYMqT0eDSzjBZ{lTUFKNKFLpc5RqdilvT1igdIVxfGmmZTDzeYJ{fHKjdHWgZYRlcXSrb36gZYZ1\XJiM{CgcYlveyCkeTDhcJBp[XNuIFvkJF0hOC5zM{Wg{txONg>? M4[3SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUm1O|I{Lz5{OEG5OVczOzxxYU6=
BL21(DE3) MWrGeY5kfGmxbjDhd5NigQ>? M{LidmJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gRnJFPCCkcn;tc4RwdWGrbjCyJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGgLGRGOyliY3XscJMh[nliaYPveIhmem2jbDD0bZRz[XSrb36gZ4Ftd3KrbXX0dpktKEumIE2gNE4yPCEQvF2u NEPjNHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkO2O|U{QSd-Mk[zOlc2Ozl:L3G+
BL21(DE3)-R3-pRARE2 M3iwTmZ2dmO2aX;uJIF{e2G7 MWPJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IHj1cYFvKEirc{[teIFo\2WmIFLSSFMh[nKxbX;kc41icW5iMjDlfJBz\XO|ZXSgbY4hTXOlaHXybYNpcWFiY3;sbUBDVDJzKFTFN{kuWjNvcGLBVmUzKGOnbHzzMEBM\CB;IECuNVk2KM7:TT6= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF7NUeyN{c,OjhzOUW3NlM9N2F-
BL21(DE3) NVy2S455TnWwY4Tpc44h[XO|YYm= NEnNOlRDcW6maX7nJIFn\mmwaYT5JJRwKGi3bXHuJGJTTDJiYoLvcY9ld22jaX6gNkBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxJEhFTTNrIHPlcIx{KGK7IHnzc5Rp\XKvYXygeIl1emG2aX;uJINidG:{aX3leJJ6NCCNZDC9JFAvOjVizszNMi=> M3rufVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4M{[3OVM6Lz5{NkO2O|U{QTxxYU6=
BL21(DE3)-R3-pRARE2 NYCxN256TnWwY4Tpc44h[XO|YYm= MlTHTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDoeY1idiCKaYO2MZRi\2enZDDCVmQzKGK{b33v[I9u[WmwIEKg[ZhxemW|c3XkJIlvKEW|Y3jldolkcGmjIHPvcIkhSkx{MTjESVMqNVJ|LYDSRXJGOiClZXzsd{whU2RiPTCwMlI2OSEQvF2u NED6XVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG5OVczOyd-MkixPVU4OjN:L3G+
BL21(DE3) NHi2VFJHfW6ldHnvckBie3OjeR?= M2TZdWJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gRnJFPCCkcn;tc4RwdWGrbjCxJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGgLGRGOyliY3XscJMh[nliaYPveIhmem2jbDD0bZRz[XSrb36gZ4Ftd3KrbXX0dpktKEumIE2gNU4yKM7:TT6= MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjN4N{WzPUc,OjZ|Nke1N|k9N2F-
BL21(DE3)-R3-pRARE2 NIKwVFFHfW6ldHnvckBie3OjeR?= NHXhVlVKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFjpd|YufGGpZ3XkJGJTTDRiYoLvcY9ld22jaX6gNUBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxLGRGOylvUkOtdHJCWkV{IHPlcIx{KHC{ZXnuZ5Vj[XSnZDDmc5IhOzBibXnud{Bnd2yub4fl[EBjgSCKNFu1ZYNMQGGlS{GyZYNMOT[jYzDw[ZB1cWSnIIP1ZpN1emG2ZTDh[IRqfGmxbjDh[pRmeiB|MDDtbY5{KGK7IHHsdIhie2O{ZXXuJIF{e2G7LDDL[EA:KDFwMUSyJO69VS5? NEPGOHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG5OVczOyd-MkixPVU4OjN:L3G+
SAE MWjGeY5kfGmxbjDhd5NigQ>? MViyOEBpenN? MV3Jcohq[mm2aX;uJI9nKEKURESgbY4hcHWvYX6gV2FGKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDUUHI{KGGpb37pd5QheG:ueTjJPmMqKC2rbnT1Z4VlKEmVR{W0JHJPSSCneIDy[ZN{cW:wIIDy[Ylv[3WkYYTl[EBnd3JiMkSgbJJ{KG[xbHzve4VlKGK7IIDvcJkpUTqFKTDh[IRqfGmxbjDhcoQhdWWjc4Xy[YQh[W[2ZYKgOEBpenNiYomgV3lDWiCpcnXlckBlgWVvYnHz[YQheVKWLWDDVkBidmGueYPpd{whUUN3MDC9JFIvPjNizszNMi=> NF64bGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[0PVc1OSd-Mkm2OFk4PDF:L3G+
SAE MWTGeY5kfGmxbjDhd5NigQ>? M4DQSVI1KGi{cx?= NH7LXI5KdmirYnn0bY9vKG:oIFLSSFQhcW5iaIXtZY4hW0GHIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBVVFJ|IHHnc45qe3RicH;sfUhKQkNrID3pcoR2[2WmIFnTS|U3KFKQQTDlfJBz\XO|aX;uJJBz\WmwY4XiZZRm\CCob4KgNlQhcHK|IH\vcIxwf2WmIHL5JJBwdHlqSUrDLUBi\GSrdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhPCCqcoOgZpkhW1mEUjDndoVmdiCmeXWtZoF{\WRicWLUMXBEWiCjbnHsfZNqeyxiSVO1NEA:KDJwN{Sg{txONg>? NIjhWm49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[0PVc1OSd-Mkm2OFk4PDF:L3G+
SAE NFrLcZlHfW6ldHnvckBie3OjeR?= MVGyOEBpenN? MVPJcohq[mm2aX;uJI9nKEKURESgbY4hcHWvYX6gV2FGKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDUUHI{KGGpb37pd5QheG:ueTjJPmMqKC2rbnT1Z4VlKGe{b3LleIEhWk6DIHX4dJJme3Orb36gdJJmcW6ldXLheIVlKG[xcjCyOEBpenNiZn;scI94\WRiYomgdI9tgSiLOlOpJIFl\Gm2aX;uJIFv\CCvZXHzeZJm\CCjZoTldkA1KGi{czDifUBUYUKUIHfy[YVvKGS7ZT3iZZNm\CCzUmStVGNTKGGwYXz5d4l{NCCLQ{WwJF0hOy55MzFOwG0v NW\vRndyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm2OFk4PDFpPkK5OlQ6PzRzPD;hQi=>
SAE NIXLdHFHfW6ldHnvckBie3OjeR?= MYOyOEBpenN? NWHGV|FnUW6qaXLpeIlwdiCxZjDCVmQ1KGmwIHj1cYFvKFODRTDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4hXEyUMzDh[49vcXO2IIDvcJkpUTqFKTCtbY5lfWOnZDDJUE05KFKQQTDlfJBz\XO|aX;uJJBz\WmwY4XiZZRm\CCob4KgNlQhcHK|IH\vcIxwf2WmIHL5JJBwdHlqSUrDLUBi\GSrdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhPCCqcoOgZpkhW1mEUjDndoVmdiCmeXWtZoF{\WRicWLUMXBEWiCjbnHsfZNqeyxiSVO1NEA:KDNwOEWg{txONg>? M2P4TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NkS5O|QyLz5{OU[0PVc1OTxxYU6=
BL21(DE3)-R3-pRARE2 NFPzVppHfW6ldHnvckBie3OjeR?= NEHmPVRKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFjpd|YufGGpZ3XkJGJTTDNiYoLvcY9ld22jaX6gNUBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxLGRGOylvUkOtdHJCWkV{IHPlcIx{NCCNZDC9JFQvODZ3IN88UU4> M2XzV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUm1O|I{Lz5{OEG5OVczOzxxYU6=
MV4-11 NHzXfItCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= Ml\LO|IhcHK| M3XDNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTW[0MVEyKGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTBiPTC0MlQ5KM7:TT6= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd4NUCxN{c,Ojh5NkWwNVM9N2F-
BL21(DE3)-R3-pRARE2 MVjGeY5kfGmxbjDhd5NigQ>? NEDOVG5KdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIFjpd|YufGGpZ3XkJGJTTDJiYoLvcY9ld22jaX6gNUBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxLGRGOylvUkOtdHJCWkV{IHPlcIx{NCCNZDC9JFUvPzhizszNMi=> M4fT[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUm1O|I{Lz5{OEG5OVczOzxxYU6=
BL21(DE3) Mn[1SpVv[3Srb36gZZN{[Xl? M1XDRWJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gRnJFOiCkcn;tc4RwdWGrbjCxJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGgLGRGOyliY3XscJMh[nliaYPveIhmem2jbDD0bZRz[XSrb36gZ4Ftd3KrbXX0dpktKEumIE2gOU45KM7:TT6= NW[3fFhLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[zOlc2OzlpPkK2N|Y4PTN7PD;hQi=>
OCI-AML3 MX7BcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MnjMO|IhcHK| NHH0Z3pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF;DTU1CVUx|IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUCgQUA4NjF5IN88UU4> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd4NUCxN{c,Ojh5NkWwNVM9N2F-
OCI-AML2 Mn7nRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXe3NkBpenN? NY[4e2VLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDPR2kuSU2OMjDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwJF0hQC5|MTFOwG0v MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd4NUCxN{c,Ojh5NkWwNVM9N2F-
MCF7 NIDMRXFCfXSxcHjh[5kh[XO|YYm= NWjS[GNIOTVyIIXN M1;Pe2lv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{Bld3ewcnXneYxifGmxbjDv[kBxPjJxU2HTWG0yKGW6cILld5Nqd25iYYSgNVUxKHWPIHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqew>? NGDpTlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG3NlU1OCd-MkmxO|I2PDB:L3G+
MDA-MB-231 NX7tbXJCSXW2b4DoZYd6KGG|c3H5 MXOxOVAhfU1? Mn7jTY5lfWO2aX;uJI9nKGG3dH;wbIFogSCrbjDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGG|c3Xzd4VlKGG|IHTve45z\We3bHH0bY9vKG:oIIC2Nk9UWVOWTUGg[ZhxemW|c3nvckBifCBzNUCgeW0h[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nz MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF5MkW0NEc,OjlzN{K1OFA9N2F-

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p21 / p24 / β-actin; 

PubMed: 29789664     


Apabetalone specifically induced apoptosis in HIV-1 latent cells by causing p21waf1/Cip1-dependent G1/G0 phase cell cycle arrest. b. Apabetalone induced the expression of p21waf1/Cip1.

cyclin D1 / CDK4 / CDK6 / p24 / β-actin; 

PubMed: 29789664     


Apabetalone specifically induced apoptosis in HIV-1 latent cells by causing p21waf1/Cip1-dependent G1/G0 phase cell cycle arrest. c. Apabetalone reduced the levels of cyclin D1 and CDK4/6 expression.

Rb / p-Rb(S780) / p-Rb(S795) / p-Rb(S807/811) / β-actin; 

PubMed: 29789664     


Apabetalone specifically induced apoptosis in HIV-1 latent cells by causing p21waf1/Cip1-dependent G1/G0 phase cell cycle arrest. d. Apabetalone reduced the phosphorylation of Rb protein S780, S795, and S807/S811, and caused the accumulation of Rb protein.

Cyclin T1 / CDK9-55kDa / CDK9-42kDa / p-CDK9 / CTD / CTD-Ser2P / p24 / β-actin; 

PubMed: 29789664     


Apabetalone stimulated latent HIV-1 via a Tat-dependent P-TEFb pathway. Apabetalone increased cyclin T1 expression and induced CDK9 T-loop and RNAP II CTD phosphorylation in ACH2 cells in c dose-dependent and d time-dependent manners.

Phospho-RelA / Total-RelA / Actin / BRD2 / α-Tubulin; 

PubMed: 31300040     


Apabetalone does not interfere with NF-kB translocation from the cytoplasm to the nucleus or association of RelA with the chromatin shown via western blot and ChIP. a Western blot: Phospho-RelA and total-RelA is found almost exclusively in the HUVEC cytoplasm (C) under unstimulated conditions (DMSO).

29789664 31300040
Immunofluorescence
monocyte adhesion; 

PubMed: 31300040     


Apabetalone prevents monocyte adhesion to endothelial cells. a Static assay. Endothelial cell monolayer was pretreated with DMSO, JQ1, or apabetalone for 1 h before the addition of TNFα (2.5 ng/ml; 4 h incubation). Monocytes (0.5 × 106cells/mL; loaded with calcein-AM) had 1 h to adhere to the monolayer before washes and fluorescence measures (plate reader).

DNA SARS-CoV-2 CTNT; 

PubMed: 33811809     


(K) Immunostaining of cardiomyocytes and SARS-CoV-2 reveals that 30 μM apabetalone preserves cardiomyocyte structures and reduces viral loading.

31300040 33811809
In vivo RVX-208 significantly increases serum apoA-I and HDL-C in AGMs, and enhances cholesterol efflux via different pathways. [3]

Protocol

Animal Research:

[3]

- Collapse
  • Animal Models: Naïve adult male AGMs
  • Dosages: ~60 mg/kg
  • Administration: Oral gavage or intravenous administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.78 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
0.5% CMC Na (1N HCl, PH 2.5-3.0)
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 370.4
Formula

C20H22N2O5

CAS No. 1044870-39-4
Storage powder
in solvent
Synonyms RVX-000222
Smiles CC1=CC(=CC(=C1OCCO)C)C2=NC3=C(C(=CC(=C3)OC)OC)C(=O)N2

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03160430 Unknown status Drug: apabetalone|Drug: Placebos Kidney Failure Chronic Resverlogix Corp March 1 2020 Phase 1|Phase 2
NCT03228940 Unknown status Drug: RVX000222 Fabry Disease Resverlogix Corp September 30 2019 Phase 1|Phase 2
NCT01863225 Terminated Drug: RVX000222|Drug: Rosuvastatin|Drug: Atorvastatin Dyslipidemia|Coronary Artery Disease Resverlogix Corp|South Australian Health and Medical Research Institute May 2013 Phase 2
NCT01728467 Completed Drug: RVX000222|Drug: Placebo RVX000222 Diabetes Resverlogix Corp|Baker Heart and Diabetes Institute|Nucleus Network Ltd November 2012 Phase 2
NCT01067820 Completed Drug: RVX000222|Drug: Placebo RVX000222 Coronary Artery Disease Resverlogix Corp|The Cleveland Clinic September 2011 Phase 2
NCT01423188 Completed Drug: RVX000222|Drug: Placebo RVX000222 Coronary Artery Disease|Dyslipidemia Resverlogix Corp|The Cleveland Clinic August 2011 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Epigenetic Reader Domain Signaling Pathway Map

Tags: buy Apabetalone (RVX-208) | Apabetalone (RVX-208) supplier | purchase Apabetalone (RVX-208) | Apabetalone (RVX-208) cost | Apabetalone (RVX-208) manufacturer | order Apabetalone (RVX-208) | Apabetalone (RVX-208) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID