Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.

Size Price Stock Quantity  
In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 570 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 38 Publications

5 Customer Reviews

  • Immunoblot analysis of serum starved H2030 cells pre-treated with 500 nM or 1 µM of gefitinib, crizotinib, CP-724714, or afatinib for 12 hr, followed by stimulation with EGF, HGF, NRG1, or their combination (50 ng/ml) for 10 min.

    Nature, 2016, 534(7609):647-51. Afatinib (BIBW2992) purchased from Selleck.

    Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NXOzZY9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jwTWlEPTB;MD6wNFU4OiEQvF2= MonNV2FPT0WU
KASUMI-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrxbHdKSzVyPUCuNFA6OTFizszN MYLTRW5ITVJ?
HCC2218 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEC5PFch|ryP M2XPeXNCVkeHUh?=
KARPAS-45 M4TjR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\1b5BoUUN3ME2wMlAyPjdzIN88US=> MnfqV2FPT0WU
HSC-4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK0fJdKSzVyPUCuNFE4PDhizszN MlziV2FPT0WU
CHL-1 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Xm[WlEPTB;MD6wNVg{QSEQvF2= NVy5OZN1W0GQR1XS
KY821 NWTZZoJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEKwOkDPxE1? NIi3PWJUSU6JRWK=
NCI-N87 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXVTWM2OD1yLkCyO|c{KM7:TR?= MXrTRW5ITVJ?
DOK NIm4NIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMEOxPVQh|ryP MULTRW5ITVJ?
DSH1 NEP4WlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1G3SGlEPTB;MD6wN|MyPCEQvF2= NGTk[HpUSU6JRWK=
MDA-MB-175-VII MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHJW5lKSzVyPUCuNFM1OTZizszN MVXTRW5ITVJ?
NCI-H2170 NV;ZZXBOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwMEO3Nlgh|ryP MWrTRW5ITVJ?
BT-474 M1rBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;TTWM2OD1yLkC0PVg3KM7:TR?= MU\TRW5ITVJ?
EFO-27 NHrrV41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HH[GlEPTB;MD6wOVE5OiEQvF2= M{TYbnNCVkeHUh?=
NCI-H720 MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEWzNlUh|ryP MoT3V2FPT0WU
PC-14 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLVeFRJUUN3ME2wMlA2PjZ6IN88US=> M1Pq[HNCVkeHUh?=
EC-GI-10 M1;x[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMEW5NVIh|ryP M4D4XnNCVkeHUh?=
KYSE-450 NHfCOYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TUcWlEPTB;MD6wOVk4QCEQvF2= M2LxUnNCVkeHUh?=
BPH-1 NUO1c3FXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoT3TWM2OD1yLkC1PVg5KM7:TR?= Ml[5V2FPT0WU
NCI-H292 NUTMUXd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVW3WoJFUUN3ME2wMlA3ODlizszN MYnTRW5ITVJ?
H9 NHP2WZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HUPGlEPTB;MD6wO|E{OiEQvF2= MWfTRW5ITVJ?
NCI-H526 MkToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7zRnBKSzVyPUCuNFc5OjNizszN NIjveWtUSU6JRWK=
NCI-H1623 Ml61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlqwTWM2OD1yLkC4NFI2KM7:TR?= M{fZUHNCVkeHUh?=
KYSE-140 NGTTN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHpTWM2OD1yLkC4N|Mh|ryP NXTBR4VkW0GQR1XS
Ca9-22 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEizOVMh|ryP MXjTRW5ITVJ?
AU565 NIHUeHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS3dGhKSzVyPUCuNFg2ODRizszN NYTEXXhUW0GQR1XS
ZR-75-30 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWCyOJZKUUN3ME2wMlA6PTR3IN88US=> NHLS[2lUSU6JRWK=
NCI-H1770 MkjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMUCyPEDPxE1? NWrJNHV2W0GQR1XS
LB2241-RCC M1S5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjJTWM2OD1yLkGwPFg1KM7:TR?= MYrTRW5ITVJ?
CAL-39 MkDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMUG3PVIh|ryP M{PvRXNCVkeHUh?=
UACC-893 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnPOIhNUUN3ME2wMlEyQDh3IN88US=> M{DQPHNCVkeHUh?=
LU-65 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\xZpVKSzVyPUCuNVI3OzNizszN MYPTRW5ITVJ?
HN NU[3U2d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfzTWM2OD1yLkGzNFc4KM7:TR?= MUjTRW5ITVJ?
TI-73 M3m4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMUS3NVUh|ryP MVjTRW5ITVJ?
KU812 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMUW0OVYh|ryP NVLYSVdbW0GQR1XS
SW13 MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMU[yNVYh|ryP MYXTRW5ITVJ?
BB30-HNC M4j6dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP6TWM2OD1yLkG2OVc3KM7:TR?= M3fWTXNCVkeHUh?=
HSC-2 NID4[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMU[4N|ch|ryP MkjVV2FPT0WU
BV-173 NV31TYNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz2eZhHUUN3ME2wMlE4PTl4IN88US=> NI\5V5dUSU6JRWK=
CAL-27 M3fKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDOTWM2OD1yLkG3OlM3KM7:TR?= Mnz3V2FPT0WU
SBC-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TqcWlEPTB;MD6xPFk2QSEQvF2= NWLo[Yw{W0GQR1XS
CAL-33 Moj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTpUJJKSzVyPUCuNlAyQDRizszN NVnVVlNNW0GQR1XS
NCI-H209 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vCdGlEPTB;MD6yNFQ3KM7:TR?= NYD3SW5SW0GQR1XS
COR-L105 M1jLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnjbldZUUN3ME2wMlIyODh2IN88US=> M3nabXNCVkeHUh?=
HSC-3 MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTlNpJCUUN3ME2wMlIyOTl6IN88US=> MVnTRW5ITVJ?
NCI-H69 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjXRVlKSzVyPUCuNlE1PTFizszN NYT1WmwzW0GQR1XS
MOLT-13 NHLIcGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMkO5O|Uh|ryP Ml;QV2FPT0WU
ML-2 NVXUOnNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMkS4NFIh|ryP NX24VodkW0GQR1XS
IGROV-1 NF7aUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlj1TWM2OD1yLkK1PVUzKM7:TR?= M4\2XHNCVkeHUh?=
TK10 M{K5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkm5TWM2OD1yLkK2O|M5KM7:TR?= NV\WWJgyW0GQR1XS
EoL-1-cell NWHOSHFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfHTWM2OD1yLkK2PFkzKM7:TR?= MVfTRW5ITVJ?
HO-1-N-1 NFHSenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn4dmpKUUN3ME2wMlI4QDV|IN88US=> MoLiV2FPT0WU
BHY M{jTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jWS2lEPTB;MD6yPFY2PSEQvF2= NHPLbYxUSU6JRWK=
LU-139 NUHCNpJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPPTWM2OD1yLkOwOVEh|ryP MVXTRW5ITVJ?
23132-87 NFPqVoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwM{G5NlMh|ryP NHH0OppUSU6JRWK=
ACHN MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwM{G5PVQh|ryP M3e1[nNCVkeHUh?=
DoTc2-4510 M4j6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\XSJRKSzVyPUCuN|IzOTlizszN M1GzSnNCVkeHUh?=
BB65-RCC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LDXGlEPTB;MD6zOFU6OyEQvF2= MlnrV2FPT0WU
HLE Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jPfmlEPTB;MD6zOVA1PiEQvF2= NF:2UpRUSU6JRWK=
HCC1419 NIezO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DLbWlEPTB;MD6zOlQxQCEQvF2= NFj5eXBUSU6JRWK=
A388 NWrVcpRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDmZXJKSzVyPUCuN|Y5PTdizszN MW\TRW5ITVJ?
NUGC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL1O5lKSzVyPUCuN|g{PzNizszN NYXIRYg1W0GQR1XS
KYSE-180 M{nydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT3d5dKSzVyPUCuN|kxQDlizszN NUnDPIl2W0GQR1XS
TE-6 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHo[FBKSzVyPUCuOFAzPDZizszN MWfTRW5ITVJ?
A498 NF:xdVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwNEC2O|Qh|ryP M3;0THNCVkeHUh?=
NCI-H1648 NUHFdZNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[3WFgxUUN3ME2wMlQ1OTh{IN88US=> NYXjdohPW0GQR1XS
DU-145 M1PaNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDHd|dVUUN3ME2wMlQ1QDN|IN88US=> NFn6U2tUSU6JRWK=
CW-2 NYfxPFluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vwRmlEPTB;MD60OlkyPCEQvF2= NWG0UFdCW0GQR1XS
A431 NGTkXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvnOm9KSzVyPUCuOFgzOzNizszN MlvZV2FPT0WU
SAS MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfEWpRKSzVyPUCuOFg{QThizszN MXrTRW5ITVJ?
NCI-H2126 NV7WXVU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XHZmlEPTB;MD61NVkzPiEQvF2= M2qwTHNCVkeHUh?=
NCI-H358 NGrqeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwNUOyNUDPxE1? NH6zbmZUSU6JRWK=
FADU NH;sVnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LufmlEPTB;MD61OFQxPCEQvF2= NGKzc|hUSU6JRWK=
ACN MkfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwNUWwPVQh|ryP MV\TRW5ITVJ?
HCC70 MkjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3QTWM2OD1yLkW3OlYyKM7:TR?= MXrTRW5ITVJ?
NCI-H1838 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HnT2lEPTB;MD62NFI6QSEQvF2= MU\TRW5ITVJ?
CAL-54 NY\sbJFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwNkG2NlEh|ryP NYLLfZB{W0GQR1XS
NCI-H1975 NEPrbXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\1TWM2OD1yLk[xO|I5KM7:TR?= M3XEfnNCVkeHUh?=
COR-L88 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f3N2lEPTB;MD62OFEyOyEQvF2= NGfPRoxUSU6JRWK=
CTV-1 NVXKdpNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli2TWM2OD1yLk[0N|kzKM7:TR?= MWHTRW5ITVJ?
EW-18 NWPTRXV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7s[3dMUUN3ME2wMlY5Pjl6IN88US=> MkXTV2FPT0WU
HCC1806 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrPTWM2OD1yLk[5OlY3KM7:TR?= M1r1ZnNCVkeHUh?=
HuP-T4 NH;lV|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13md2lEPTB;MD62PVc3KM7:TR?= MonrV2FPT0WU
MDA-MB-361 MlXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwN{K2OlIh|ryP M1rldHNCVkeHUh?=
NCI-H1573 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rLWmlEPTB;MD63N|Y{KM7:TR?= MmXIV2FPT0WU
KU-19-19 NWfxT2htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjNTWM2OD1yLke3OFY1KM7:TR?= MXzTRW5ITVJ?
COLO-678 NEj5[mJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjwc5NpUUN3ME2wMlgxQDN2IN88US=> NHzkNHZUSU6JRWK=
C-33-A NEPsTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;IdIM4UUN3ME2wMlgyOjl5IN88US=> NWLNVZlyW0GQR1XS
Calu-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f3e2lEPTB;MD64NVQ{PCEQvF2= MlzVV2FPT0WU
AGS MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS4U282UUN3ME2wMlg{PjR6IN88US=> M{PLS3NCVkeHUh?=
SCC-25 M3LUPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVm5XWhXUUN3ME2wMlg1OTdzIN88US=> NFrBelhUSU6JRWK=
JVM-2 Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLrO3lKSzVyPUCuPFgzQTlizszN M1HnfnNCVkeHUh?=
HCE-T MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIThSnhKSzVyPUCuPFg1OjhizszN M33mbHNCVkeHUh?=
ES4 MmewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwOUe4N|Yh|ryP NFHHZmFUSU6JRWK=
EKVX NEXuPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFwMEGwOlQh|ryP MlTBV2FPT0WU
D-542MG NE\Ve5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TFSWlEPTB;MT6wNVA3PCEQvF2= NXXJVFB6W0GQR1XS
SW1116 M3PZbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXie3RKSzVyPUGuNFEzQDdizszN MmDyV2FPT0WU
5637 M4jV[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFwMEG1NUDPxE1? MXLTRW5ITVJ?
HT-1376 MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NICwcFVKSzVyPUGuNFE2OTNizszN NVn3SmZjW0GQR1XS
NB69 NHXDdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHKyW3pKSzVyPUGuNFI6PDVizszN MYLTRW5ITVJ?
YKG-1 NF;hc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHiV4NKSzVyPUGuNFU1OTlizszN MUfTRW5ITVJ?
EW-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTzTWM2OD1zLkC3PFg{KM7:TR?= NH:yXW5USU6JRWK=
GCIY M2rTfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfsOohKSzVyPUGuNFgyODRizszN M4PGcnNCVkeHUh?=
SK-MES-1 NX;lOYIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUG3fllMUUN3ME2xMlEyPDh5IN88US=> MVvTRW5ITVJ?
PANC-08-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFwMU[0NVYh|ryP NXzneYJwW0GQR1XS
SK-NEP-1 NF;TZlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUT1ZZFZUUN3ME2xMlE4PTF|IN88US=> NYX1VpJsW0GQR1XS
SW954 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi1fW9ZUUN3ME2xMlIxOjF2IN88US=> M4fURnNCVkeHUh?=
NCI-SNU-5 MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln0TWM2OD1zLkKzPUDPxE1? MkTCV2FPT0WU
SW48 M4L4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXniRVFUUUN3ME2xMlI2PDN{IN88US=> MVXTRW5ITVJ?
HT-3 M4\VbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTFwMki3OVMh|ryP MVzTRW5ITVJ?
ETK-1 M4jFNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\yUWhKSzVyPUGuN|c1PTZizszN NVHSWW13W0GQR1XS
SCC-15 M3LaNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFwM{m0OVEh|ryP MoK2V2FPT0WU
DU-4475 NHLpXYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\FTWM2OD1zLkSwNVIyKM7:TR?= M1vzZ3NCVkeHUh?=
NB5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkK3TWM2OD1zLkSxN|E4KM7:TR?= MVjTRW5ITVJ?
CFPAC-1 NEP1bVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzITWM2OD1zLkSyOFk{KM7:TR?= MW\TRW5ITVJ?
NCI-H630 MnrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TtPWlEPTB;MT60OVU5OiEQvF2= MlzMV2FPT0WU
NCI-H82 M4fXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M323ZWlEPTB;MT61OFAxPiEQvF2= Ml7TV2FPT0WU
ECC10 MlHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXWdGRJUUN3ME2xMlU2OzZ7IN88US=> NUfVNFc6W0GQR1XS
K5 MoX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;4UGV6UUN3ME2xMlU5OzV5IN88US=> NWruOG5FW0GQR1XS
ME-180 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnHTWM2OD1zLk[xNFk3KM7:TR?= M1nCXHNCVkeHUh?=
KYSE-410 Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvXR2FKSzVyPUGuOlU3PzJizszN MkW5V2FPT0WU
G-401 M1XYUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrWN4hiUUN3ME2xMlY4PDF|IN88US=> NVnMb21oW0GQR1XS
TGBC24TKB M1zOe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT1[otKSzVyPUGuOlgzOyEQvF2= NFLtc2NUSU6JRWK=
Detroit562 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFwN{CxOVIh|ryP NYS0UW5MW0GQR1XS
OE19 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrUV4RKSzVyPUGuO|E2OTJizszN M4[1NXNCVkeHUh?=
CAKI-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2O5OWlEPTB;MT63PFIyOSEQvF2= M1r1UnNCVkeHUh?=
TE-12 NYDHbVFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLLfYhVUUN3ME2xMlgxPDF2IN88US=> M4LMdHNCVkeHUh?=
NCI-H1666 NELVVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPleXFKSzVyPUGuPFA6PDhizszN M4XNPXNCVkeHUh?=
TE-1 MlTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXqwN2xzUUN3ME2xMlgyPDd3IN88US=> NGnEZ3hUSU6JRWK=
CAL-12T MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYmyRldiUUN3ME2xMlg5QTR3IN88US=> MXXTRW5ITVJ?
TE-8 NFTQVmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rV[WlEPTB;MT65NVM4PyEQvF2= M{\3UnNCVkeHUh?=
KYSE-270 NHLIfY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X3d2lEPTB;Mj6wNlc{OiEQvF2= NI\h[WlUSU6JRWK=
GMS-10 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTJwMEO1NVch|ryP NUDvSHFjW0GQR1XS
A2780 NH3mUHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvlW3M4UUN3ME2yMlA3Ojl2IN88US=> NGS3cFRUSU6JRWK=
OMC-1 NVe0fHJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXOc3RKSzVyPUKuNFgyPjlizszN MXvTRW5ITVJ?
LoVo MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHJUWNKSzVyPUKuNVA4QTdizszN Ml7yV2FPT0WU
PANC-03-27 NXOwUJY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJwMU[2N|Eh|ryP M3vscnNCVkeHUh?=
MDA-MB-157 Ml:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkW1TWM2OD1{LkKxPFI5KM7:TR?= NXXXZ5lrW0GQR1XS
CaR-1 MlTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3W1SWlEPTB;Mj6yPFI5OSEQvF2= NIe1TJBUSU6JRWK=
769-P M4DQfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nETGlEPTB;Mj6yPVA{PyEQvF2= MmPRV2FPT0WU
NB7 NE\tS|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nkeGlEPTB;Mj6yPVY4PiEQvF2= M4\0UXNCVkeHUh?=
MKN7 M2\G[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTJwM{WzN|Uh|ryP NU\a[ppDW0GQR1XS
NCI-H1048 M3\ONGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjEPYYyUUN3ME2yMlQ6OTV6IN88US=> MorrV2FPT0WU
RCM-1 NWTUPY8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjqNYVSUUN3ME2yMlUzQTN6IN88US=> MXvTRW5ITVJ?
HT55 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDKUWJ7UUN3ME2yMlU4OzhizszN Mk\0V2FPT0WU
HCC1569 M3;PbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvZTWM2OD1{LkW4Nlk4KM7:TR?= NIWzWYNUSU6JRWK=
LXF-289 M2rqOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\tbm1KSzVyPUKuOlM2PjVizszN NXPt[ZRzW0GQR1XS
OVCAR-3 M3rqc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[0d4tKSzVyPUKuOlcyPjdizszN NW[wOYZ3W0GQR1XS
TE-10 Ml;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmX6TWM2OD1{Lk[4NFc5KM7:TR?= MmW4V2FPT0WU
SNU-C2B MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fxcWlEPTB;Mj62PFYyPiEQvF2= NFKxcWpUSU6JRWK=
LB1047-RCC NVjwXVVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJwN{S4PFgh|ryP M4HSR3NCVkeHUh?=
SN12C NVTaPHNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJwOUG5OlQh|ryP Ml;ZV2FPT0WU
786-0 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTVUJZKSzVyPUOuNFY1ODhizszN M3iyTXNCVkeHUh?=
HT-29 M1zIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofJTWM2OD1|LkC3N|A6KM7:TR?= MlLGV2FPT0WU
RPMI-7951 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoD3TWM2OD1|LkC3OVkh|ryP Mmj5V2FPT0WU
NBsusSR NFrZWI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf0dXRKSzVyPUOuNVgzPTRizszN M1vKSnNCVkeHUh?=
NKM-1 M2S2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf0fXpKSzVyPUOuNVg4PDRizszN NV;Yfo0xW0GQR1XS
Capan-2 NFfmPJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTNwNE[4O|Uh|ryP MVzTRW5ITVJ?
MKN1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHz[oVYUUN3ME2zMlQ4OTB6IN88US=> MWrTRW5ITVJ?
OAW-42 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTNwNUCwNlYh|ryP M4TDZnNCVkeHUh?=
SKG-IIIa M4nLVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTkTWM2OD1|LkWyNlM4KM7:TR?= Mn[xV2FPT0WU
no-11 Mk\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojUTWM2OD1|LkWzOVY1KM7:TR?= M{LqOXNCVkeHUh?=
NY NX\HZ5ZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjYempGUUN3ME2zMlU{PjV3IN88US=> M4PCUnNCVkeHUh?=
HEC-1 M2KxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;QdGlEPTB;Mz61PFk2KM7:TR?= NIHwSJVUSU6JRWK=
NCI-H441 NHnORpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfUTWM2OD1|LkW5PFQyKM7:TR?= MVXTRW5ITVJ?
NCI-H2009 MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTNwNkGyNVYh|ryP NE\4doRUSU6JRWK=
T47D NHq1S5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTNwNkKyNVch|ryP M2fiXHNCVkeHUh?=
SNU-449 NEH2NJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELRRlZKSzVyPUOuOlU5OjZizszN MlHUV2FPT0WU
NCI-SNU-1 NYeyNXFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PNVWlEPTB;Mz62PVc{PSEQvF2= NF:zZWtUSU6JRWK=
BT-20 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTNwNkm3PVUh|ryP MYrTRW5ITVJ?
LS-123 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHvTWM2OD1|Lke0Nlg1KM7:TR?= MlfEV2FPT0WU
8305C MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL2TWM2OD1|Lke1PVEyKM7:TR?= MmnrV2FPT0WU
OCUB-M MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7SeYxKSzVyPUOuO|YyQDdizszN NFW4bnlUSU6JRWK=
KOSC-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;zRZRqUUN3ME2zMlg{PDVzIN88US=> Moq4V2FPT0WU
NCI-H1693 NV;xUJhjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzGWGlWUUN3ME2zMlg1OThzIN88US=> NWLIR3RmW0GQR1XS
TE-9 M2Hndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjhZVVKSzVyPUOuPFQ{QDJizszN MnT1V2FPT0WU
MV-4-11 MofmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvKTWM2OD1|Lki3PVk1KM7:TR?= MX;TRW5ITVJ?
GAMG M2DGUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PQXmlEPTB;Mz65NVMyPCEQvF2= NUHQe|RiW0GQR1XS
KNS-62 MlfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzZTWM2OD1|Lkm0O|MyKM7:TR?= M4PxVnNCVkeHUh?=
MC116 M1rmOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LwTGlEPTB;Mz65OVQ5QSEQvF2= M2W1SHNCVkeHUh?=
647-V M2i5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlj5TWM2OD1|Lkm4OFUzKM7:TR?= M1G5fHNCVkeHUh?=
U-87-MG NEDjeGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS3PXFKSzVyPUSuNVA1QDFizszN NF7MWWlUSU6JRWK=
RPMI-8226 M2L0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTpUIxKSzVyPUSuNVE3OzFizszN MWTTRW5ITVJ?
SW1417 M2XCVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfyR3c2UUN3ME20MlEzOTR5IN88US=> MUHTRW5ITVJ?
LAMA-84 NITofm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTRwMUewNkDPxE1? NIKxXVBUSU6JRWK=
LS-513 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjXeFdKSzVyPUSuN|EzOTdizszN MU\TRW5ITVJ?
KLE MoL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXuTWM2OD12LkSwPFE6KM7:TR?= M4DIVnNCVkeHUh?=
HCT-116 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYezdJNQUUN3ME20MlQyODB5IN88US=> NEDNbGVUSU6JRWK=
EPLC-272H M2XJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfLW2hKSzVyPUSuOFE2OzNizszN Mnq4V2FPT0WU
KS-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fqOWlEPTB;ND61NFg5QSEQvF2= NYXxV|dsW0GQR1XS
HT-1197 MlTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLyTWM2OD12LkWyOlY6KM7:TR?= NVfIRohpW0GQR1XS
LCLC-97TM1 MkG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP3cIVIUUN3ME20MlU{Pjh4IN88US=> NUDLfJg6W0GQR1XS
ES5 M{LNU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTRwOEO3NlMh|ryP M{f6U3NCVkeHUh?=
CTB-1 NUjzNIwxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfsPXdwUUN3ME20Mlg1QDhizszN NFn5VZhUSU6JRWK=
HL-60 M4myUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\YTWM2OD12Lki2OlEyKM7:TR?= NYXieHZbW0GQR1XS
VM-CUB-1 NYXxPFJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jhTWlEPTB;ND64OlgyQSEQvF2= NGX0VG9USU6JRWK=
MEG-01 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzOVWtUUUN3ME20Mlk6PDB|IN88US=> MULTRW5ITVJ?
KYSE-520 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPwTWM2OD13LkKwPFM6KM7:TR?= MWjTRW5ITVJ?
HuO-3N1 NY\ZToE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn61TWM2OD13LkK0NFQ{KM7:TR?= MlXvV2FPT0WU
SW620 Ml\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XaOWlEPTB;NT6yOFk3PCEQvF2= MWTTRW5ITVJ?
U031 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPmTWM2OD13LkK1OFI1KM7:TR?= MlfuV2FPT0WU
TE-5 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTVwNEC4OUDPxE1? Ml3EV2FPT0WU
NCI-H747 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPxUXJEUUN3ME21MlQzPDd{IN88US=> MUPTRW5ITVJ?
MG-63 NGPGVGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPuUoI2UUN3ME21MlQ5PzZ{IN88US=> NFrWbYxUSU6JRWK=
HC-1 M3u0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfHTWM2OD13LkWxPFM6KM7:TR?= Ml3NV2FPT0WU
HCC2998 NV;WcnByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHFXnlzUUN3ME21MlUzPjF3IN88US=> NFfoUFhUSU6JRWK=
NTERA-S-cl-D1 NX;tSIhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHLTWM2OD13LkW0OVM4KM7:TR?= NVrCUHhjW0GQR1XS
KINGS-1 M2PvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nvSmlEPTB;NT62NFk1PCEQvF2= MXHTRW5ITVJ?
D-423MG MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTRTWM2OD13Lk[xO|A2KM7:TR?= NH;SPWpUSU6JRWK=
SW962 NYDNV5NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTVwNkKwN|Ih|ryP MX3TRW5ITVJ?
LOXIMVI NYi5[Ix4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fzb2lEPTB;NT62N|g4OyEQvF2= MlvhV2FPT0WU
LS-411N NFnFR|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TPOGlEPTB;NT63PVQ1OSEQvF2= MYjTRW5ITVJ?
NCI-H2291 Mo\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPiNmhKSzVyPUWuPVg6PDNizszN NEnGUWRUSU6JRWK=
A549 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\JZXRrUUN3ME22MlEzPTV|IN88US=> MVXTRW5ITVJ?
LS-1034 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljaTWM2OD14LkKwO|A3KM7:TR?= Mne4V2FPT0WU
NB14 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlqwTWM2OD14LkSzPFM3KM7:TR?= MVPTRW5ITVJ?
NCI-H1299 M4j6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSzVmlKSzVyPU[uOlMyPzFizszN NFfUenpUSU6JRWK=
BT-549 M2nkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrCdnVKSzVyPU[uOlY5QDlizszN MXTTRW5ITVJ?
J-RT3-T3-5 M1fvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIeyfVhKSzVyPU[uPFY6KM7:TR?= NGrhNYJUSU6JRWK=
SW756 MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\pWWlEPTB;Nj65NVE4PiEQvF2= M{THPHNCVkeHUh?=
DJM-1 NVXFUZhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3aOGI6UUN3ME22MlkzODF{IN88US=> M4TLRXNCVkeHUh?=
GP5d NF\FUJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLsdHJzUUN3ME22Mlk4Ozl2IN88US=> MWLTRW5ITVJ?
MOLT-4 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPTN|BKSzVyPUeuNFIyOzVizszN NITMU2NUSU6JRWK=
NCI-H28 NYrqUZpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\rRmlEPTB;Nz6xOlQxPSEQvF2= NWrlR29EW0GQR1XS
MN-60 NHf1OldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDSV|RKSzVyPUeuNlgxQDlizszN NVrnTnpmW0GQR1XS
RMG-I NFS3U3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTdwM{myPVYh|ryP NETIPYdUSU6JRWK=
COLO-800 MlrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7CSW1PUUN3ME23MlQyPDR4IN88US=> NVK2SoQ{W0GQR1XS
DB NHT4Z5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq2R203UUN3ME23MlYyODB3IN88US=> MnP6V2FPT0WU
Ca-Ski MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHuT3FKSzVyPUeuOlQzPTlizszN NUW2WpJRW0GQR1XS
HEL NFrBZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn1NGlKSzVyPUeuO|EzODNizszN MnqzV2FPT0WU
NH-12 Mnz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK0c2lFUUN3ME23MlczQDB6IN88US=> M4Kwc3NCVkeHUh?=
LB373-MEL-D MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1u2NGlEPTB;Nz63Olc4OSEQvF2= M{HGNXNCVkeHUh?=
SW900 M2HheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXryNWhJUUN3ME23MlgzOTJzIN88US=> M3zEXHNCVkeHUh?=
JVM-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTdwOEm1PVkh|ryP NHuzXolUSU6JRWK=
OAW-28 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3zTWM2OD15Lkm0OVc5KM7:TR?= NEXuc|VUSU6JRWK=
KURAMOCHI MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXS0bIV1UUN3ME23Mlk1QDFzIN88US=> NIS2N|RUSU6JRWK=
BE-13 Mnz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT2TWM2OD15Lkm4NVEzKM7:TR?= NHm1TmxUSU6JRWK=
VMRC-RCZ MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRThwMEG2PVch|ryP M{Hrc3NCVkeHUh?=
NCI-H727 M1vlNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DId2lEPTB;OD6xNFQzKM7:TR?= MXPTRW5ITVJ?
SW1710 NGD2NXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX6O3FKSzVyPUiuNVg2OTVizszN M1TB[nNCVkeHUh?=
D-502MG M17mNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\jU3RKSzVyPUiuNlkzQDJizszN M3uxWHNCVkeHUh?=
NCI-H1993 MoO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3B[4hKSzVyPUiuN|M3OzFizszN M{DGO3NCVkeHUh?=
SCC-4 M4XyNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrBPVY5UUN3ME24MlQ1ODV7IN88US=> NHGybXpUSU6JRWK=
HAL-01 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRThwNUG5NUDPxE1? NIjIZohUSU6JRWK=
GT3TKB NWrVcmM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\kSoU{UUN3ME24MlY4QTZ2IN88US=> M1;r[HNCVkeHUh?=
SK-OV-3 NHe1fVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnEbpBKSzVyPUiuO|E{OjlizszN MkLPV2FPT0WU
COLO-829 NXjMVot5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnwR2ViUUN3ME24MlgxQTd4IN88US=> MVTTRW5ITVJ?
OCI-AML2 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLVTWM2OD16Lkm1OFgyKM7:TR?= NHjjXI5USU6JRWK=
OS-RC-2 MnXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LPeGlEPTB;OT6wNlE6KM7:TR?= NVjrfFBLW0GQR1XS
BFTC-909 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETIPW9KSzVyPUmuNFY4QTlizszN NVe2THVmW0GQR1XS
EW-11 NGrrfZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\j[GlEPTB;OT6xO|Y2OyEQvF2= NHW3PFJUSU6JRWK=
HCE-4 NXPzfVRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;0TYtKSzVyPUmuNlE2PThizszN NYC0U3dFW0GQR1XS
BALL-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXX1R5RGUUN3ME25MlIyQTB5IN88US=> MkfJV2FPT0WU
SF539 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTlwMkO1OlIh|ryP MV3TRW5ITVJ?
CAMA-1 NYPrUFBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjS[pVKSzVyPUmuNlgyOjhizszN NVr1XFk3W0GQR1XS
C32 NF\XZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17zVmlEPTB;OT6zN|A3PCEQvF2= MUHTRW5ITVJ?
NCI-H1703 NVn0cmY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTlwM{SzO|Uh|ryP M{DiTXNCVkeHUh?=
NCI-H1650 NXrwZYc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHnSI52UUN3ME25MlYxQTR4IN88US=> NW[2VGhmW0GQR1XS
NCI-H1563 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTlwN{[wN|Eh|ryP M4LPNXNCVkeHUh?=
CAL-85-1 NV\LTmpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTlwOEezPFMh|ryP NXHYOG5NW0GQR1XS
UM-UC-3 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHv4O41KSzVyPUmuPVUxOyEQvF2= MlyyV2FPT0WU
BxPC-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPCTWM2OD1zMD6wPVczKM7:TR?= NELvO29USU6JRWK=
MHH-PREB-1 MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXIXY1[UUN3ME2xNE4yQTl7IN88US=> MXrTRW5ITVJ?
DEL NGHXc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe4NWJsUUN3ME2xNE4{QTR4IN88US=> NYLEXYd3W0GQR1XS
HuCCT1 NIS0VI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrWcFZKSzVyPUGwMlYxOzNizszN M4K0Z3NCVkeHUh?=
OVCAR-4 M2TjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzEOVJKSzVyPUGwMlg5OzVizszN NWXZRW12W0GQR1XS
CAL-72 NFHHVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTFyLkmzPVEh|ryP MnvsV2FPT0WU
HCC1954 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILhTJpKSzVyPUGxMlA4PTRizszN NHHVTVBUSU6JRWK=
EFO-21 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn3Z49KSzVyPUGxMlExPDVizszN MXPTRW5ITVJ?
FTC-133 Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvwTWM2OD1zMT6xOFA4KM7:TR?= M3jFWnNCVkeHUh?=
SK-MEL-24 M3rUcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf3[4lKSzVyPUGxMlI{PjZizszN M3jXSXNCVkeHUh?=
UACC-62 NEXoc3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTiTWM2OD1zMT6yN|Y5KM7:TR?= NUO5d|ZsW0GQR1XS
NCI-H650 NGTrS4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;iOWlEPTB;MUGuNlQyQCEQvF2= NIHxc|hUSU6JRWK=
ALL-PO NYnTOJlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjGdGRKSzVyPUGxMlI2OTJizszN NEnpN2dUSU6JRWK=
T84 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fRd2lEPTB;MUGuN|kxPyEQvF2= MYPTRW5ITVJ?
IST-MEL1 Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTFzLkS1OVkh|ryP M2PBSHNCVkeHUh?=
SW626 MkDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHxbmdKSzVyPUGxMlU4PTVizszN NXfVRmN3W0GQR1XS
RPMI-2650 Mn\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;JTWM2OD1zMT61PFg2KM7:TR?= NFrsUFNUSU6JRWK=
MC-IXC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHroRlNKSzVyPUGxMlY4OjhizszN NEXy[4hUSU6JRWK=
HOP-62 M4HIbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:xTWM2OD1zMT62O|Y1KM7:TR?= M1vGSXNCVkeHUh?=
NOS-1 NXjKOYRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NESycVNKSzVyPUGxMlcyODlizszN NIS5eYNUSU6JRWK=
SW1573 MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XE[2lEPTB;MUGuO|I6PSEQvF2= M1jIfXNCVkeHUh?=
WM-115 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDhTWM2OD1zMT63OVg5KM7:TR?= NULmOW5xW0GQR1XS
HuO9 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFzLki3O|Qh|ryP MmPRV2FPT0WU
YAPC M2nqdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;scm4{UUN3ME2xNU46OjV7IN88US=> NGe4[|FUSU6JRWK=
MDA-MB-453 NGn1cGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFzLkm1NVUh|ryP NVn2U|FmW0GQR1XS
NCI-H596 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFz4RmNKSzVyPUGyMlA{PjlizszN NXnaXItGW0GQR1XS
A172 NVHoSIVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfRXZlKSzVyPUGyMlA4QThizszN M1L6cnNCVkeHUh?=
RS4-11 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPTVYR3UUN3ME2xNk4yPzJ3IN88US=> NUPwPY5VW0GQR1XS
HCC1937 NEjjXHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYju[HRUUUN3ME2xNk44PTZ2IN88US=> NHPJR5lUSU6JRWK=
SW837 NXfORoQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS3dVVKSzVyPUGyMlkxOjhizszN M3vkRXNCVkeHUh?=
NMC-G1 M3TRPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP1dXhKSzVyPUGyMlkzOzRizszN MWLTRW5ITVJ?
PFSK-1 M3:ySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfiTWM2OD1zMz6wOkDPxE1? NUnINXdpW0GQR1XS
DBTRG-05MG M{HTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDmSJhKSzVyPUGzMlA3OzJizszN NHTzbWVUSU6JRWK=
SK-UT-1 M2q0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjyNXRKSzVyPUGzMlExQDNizszN M4rzdnNCVkeHUh?=
OVCAR-5 MonNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;I[mlEPTB;MUOuNVU6OyEQvF2= Mo\3V2FPT0WU
8505C NXfacVB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTF|LkKwOlch|ryP Ml;IV2FPT0WU
SK-MEL-1 NGn6bmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfTSmJ[UUN3ME2xN{44OTN3IN88US=> NH\6THNUSU6JRWK=
LK-2 NV\4U|U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fDV2lEPTB;MUOuO|Y{QSEQvF2= MmrGV2FPT0WU
OE33 NYTuXZRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTCN3hKSzVyPUGzMlc5PiEQvF2= NWLRUllnW0GQR1XS
Ramos-2G6-4C10 NUDhV2tNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnCTFdKSzVyPUG0MlAzODJizszN NV;kcpg3W0GQR1XS
EW-13 NHjiOnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHwcFFKSzVyPUG0MlA{PTJizszN NVPESJNRW0GQR1XS
NCI-H1793 NInyXmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXrSXpKSzVyPUG0MlIxQDdizszN MXfTRW5ITVJ?
BHT-101 Mo\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{K1dWlEPTB;MUSuNlQyKM7:TR?= NWrBSWp3W0GQR1XS
RKO MoCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofKTWM2OD1zND61NFc2KM7:TR?= MlniV2FPT0WU
NEC8 NUDtcopRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHqyOYlKSzVyPUG0MlU1PzJizszN NGjLWZdUSU6JRWK=
PANC-10-05 Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrBT21bUUN3ME2xOE43OjR5IN88US=> MVrTRW5ITVJ?
NCI-H2030 MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF2Lk[0OFgh|ryP NGP5[YNUSU6JRWK=
C2BBe1 MnL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTF2Lke2OEDPxE1? NHvBW29USU6JRWK=
EM-2 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTF2Lki1O|Yh|ryP NXTyPGlVW0GQR1XS
HCC1395 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTF2LkmzN|gh|ryP NYe1bZZWW0GQR1XS
A2058 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHWRVFKSzVyPUG1MlA1ODlizszN M{TicXNCVkeHUh?=
SW1463 M{LPRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[xRph1UUN3ME2xOU4xPDh3IN88US=> MkKzV2FPT0WU
J82 M3LW[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnE[Y5KSzVyPUG1MlA2PyEQvF2= NWLm[GZXW0GQR1XS
CAL-120 NHP6U3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4j0RWlEPTB;MUWuNVQ1PyEQvF2= NEjHfFRUSU6JRWK=
COLO-824 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF3LkG1O|kh|ryP Mmi2V2FPT0WU
LNCaP-Clone-FGC M2HnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDTTWM2OD1zNT60NlQ5KM7:TR?= MWDTRW5ITVJ?
CP66-MEL Mk\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:2O2NFUUN3ME2xOU41Pjh6IN88US=> NY\jTmZQW0GQR1XS
OC-314 NU\wXGJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjiXmNFUUN3ME2xOU41PzF2IN88US=> M1XyOnNCVkeHUh?=
OVCAR-8 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\wWllKSzVyPUG1Mlg5PjFizszN NGS3NXZUSU6JRWK=
MFE-280 MlLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjVWmVKSzVyPUG2MlA1QDhizszN NFHFRYpUSU6JRWK=
MHH-NB-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe2dIlsUUN3ME2xOk4xQDN7IN88US=> M1HmO3NCVkeHUh?=
SW1990 MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnUNFhKSzVyPUG2MlE4PTVizszN M2PXcnNCVkeHUh?=
U-266 M4DYNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HvPWlEPTB;MU[uNlI6QSEQvF2= MWfTRW5ITVJ?
MFM-223 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHpRldGUUN3ME2xOk4{QTZ3IN88US=> MWLTRW5ITVJ?
L-363 M4G2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnWVWJKSzVyPUG2MlQ2PzdizszN NFu2c4dUSU6JRWK=
MCF7 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHqcHpqUUN3ME2xOk41PzJ|IN88US=> NF3qOVhUSU6JRWK=
SK-MEL-3 NGXtcpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHWbmlwUUN3ME2xOk41Pzh5IN88US=> NXzKd|JmW0GQR1XS
HH M3zxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXSfmZKSzVyPUG2MlUyPjJizszN MXjTRW5ITVJ?
no-10 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTF4Lk[zOFMh|ryP NH;VVlRUSU6JRWK=
HuP-T3 Mlm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7rbYIyUUN3ME2xOk43PTd4IN88US=> NULwOW1EW0GQR1XS
QIMR-WIL NILHZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL1TmRKSzVyPUG2MlcyODVizszN MoHRV2FPT0WU
NCI-H1092 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL1TWM2OD1zNj64N|E3KM7:TR?= MlfrV2FPT0WU
MZ2-MEL MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfUTWM2OD1zNj64OFA{KM7:TR?= NGfXVmdUSU6JRWK=
ES3 M3Hx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\QVHF7UUN3ME2xOk46OTN2IN88US=> NEizNIhUSU6JRWK=
COLO-684 NUfUb3FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7pTWM2OD1zNj65OFc4KM7:TR?= M3zqcnNCVkeHUh?=
NCI-H661 M1fkWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTF4Lkm2PVQh|ryP M2\6fnNCVkeHUh?=
CP50-MEL-B NHzNW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37IfmlEPTB;MUeuNFM1OyEQvF2= NWS0S5B{W0GQR1XS
NCI-H2405 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTF5LkG5O|Qh|ryP NWjueolvW0GQR1XS
U-2-OS MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1H1[2lEPTB;MUeuOVMxPyEQvF2= Mnf4V2FPT0WU
RERF-LC-MS NIHmfFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHG4TpJKSzVyPUG3MlU2ODhizszN MWnTRW5ITVJ?
NCI-H2342 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nrN2lEPTB;MUeuOVU4KM7:TR?= NFfTXIVUSU6JRWK=
ES8 MkDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L1eGlEPTB;MUeuOlA5PyEQvF2= NY\XN4J3W0GQR1XS
MOLT-16 Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nobGlEPTB;MUeuPFk{PCEQvF2= M{\aSXNCVkeHUh?=
RH-18 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTL[3NVUUN3ME2xPE4xODN3IN88US=> NUfBVYRnW0GQR1XS
D-283MED MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXGc|FLUUN3ME2xPE4xODh6IN88US=> M1r3SnNCVkeHUh?=
RCC10RGB MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz6b3QzUUN3ME2xPE4xPTV7IN88US=> Ml23V2FPT0WU
NCI-H1437 MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTHbmt4UUN3ME2xPE4yPjRzIN88US=> MVnTRW5ITVJ?
SW982 NHfneXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVqzRoQzUUN3ME2xPE4zPjdzIN88US=> M3fzSHNCVkeHUh?=
IST-MES1 MljtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF6LkS0Nlgh|ryP M3zPOXNCVkeHUh?=
A704 NYTONmlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vQTGlEPTB;MUiuOFc2OyEQvF2= MoTEV2FPT0WU
ESS-1 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTF6LkWyNFUh|ryP NVLG[5lIW0GQR1XS
SCH M3zq[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vsUWlEPTB;MUiuOlQ2PiEQvF2= MoDOV2FPT0WU
COLO-320-HSR M2rtUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCzZ3pwUUN3ME2xPE44PDZizszN MnLEV2FPT0WU
Mo-T MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDQTWM2OD1zOD64NlA1KM7:TR?= NWrCeJQ2W0GQR1XS
Saos-2 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYq1WIVIUUN3ME2xPU4yOTZ{IN88US=> NHv4e4tUSU6JRWK=
SW684 NEPyWXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVj5bmlYUUN3ME2xPU4yOzJ4IN88US=> MYXTRW5ITVJ?
KMOE-2 M1X6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXsZZJKSzVyPUG5MlIzPDJizszN Mnz3V2FPT0WU
MMAC-SF M2C0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjsTWM2OD1zOT6yOlA4KM7:TR?= MYjTRW5ITVJ?
JAR MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjZVHlKSzVyPUG5MlI6QSEQvF2= NV63TWI{W0GQR1XS
SK-MEL-28 NVniRYNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF7LkOzOlMh|ryP MV3TRW5ITVJ?
KNS-81-FD NFXwdWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfmRWJKSzVyPUG5MlU1PjhizszN M37qbnNCVkeHUh?=
ES7 NFS1bWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLTTWM2OD1zOT62NlkzKM7:TR?= NWTZPY9YW0GQR1XS
AsPC-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm3b4FOUUN3ME2xPU43PDdzIN88US=> MlPGV2FPT0WU
NCI-H1155 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7QNmZKSzVyPUG5MlczOzhizszN MlrEV2FPT0WU
KYSE-510 NW[zTlY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj6TWM2OD1zOT64O|Q5KM7:TR?= M{H5SXNCVkeHUh?=
ES1 NGexWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HQbmlEPTB;MUmuPVIyOyEQvF2= NFLJVGJUSU6JRWK=
PC-3 NVfyTFRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLBc4hKSzVyPUG5Mlk3ODRizszN NFrs[45USU6JRWK=
GCT M{TxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJyLkOwNlYh|ryP NWnMVI1HW0GQR1XS
KARPAS-299 NE\5O4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHETWM2OD1{MD6zOFIzKM7:TR?= NEnFSldUSU6JRWK=
DOHH-2 MmH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHvbot7UUN3ME2yNE42PDZ|IN88US=> NUTWVm1RW0GQR1XS
COLO-741 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfmTWM2OD1{MD62OkDPxE1? MVzTRW5ITVJ?
NCI-H1395 NInhXIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PuZ2lEPTB;MkCuOlY6PyEQvF2= Mn20V2FPT0WU
HCC1187 M3nXb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjNTWM2OD1{MD62O|M1KM7:TR?= NUfTb|BLW0GQR1XS
Becker MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{njXmlEPTB;MkCuO|IxOSEQvF2= MYHTRW5ITVJ?
LU-134-A NG\aToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X6U2lEPTB;MkGuNVAzPiEQvF2= MYLTRW5ITVJ?
MKN45 NFXPZnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XyN2lEPTB;MkGuNVU2OSEQvF2= Mk[1V2FPT0WU
LC-2-ad NX70V5Y2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TXOWlEPTB;MkGuNlczQSEQvF2= NVv4dlRXW0GQR1XS
EW-24 Mlv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ntO2lEPTB;MkGuN|k1PSEQvF2= NXHx[oYxW0GQR1XS
SK-N-AS NGXn[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTJzLkiyO|Yh|ryP M3n5NHNCVkeHUh?=
NCI-H2052 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3iWWtKSzVyPUKxMlg6PjNizszN MW\TRW5ITVJ?
A4-Fuk NWDh[|VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTFR4VlUUN3ME2yNk4yPDF7IN88US=> MoPvV2FPT0WU
NB10 NHe1[mxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYH4RY1IUUN3ME2yNk4zOzdzIN88US=> MXLTRW5ITVJ?
CHP-212 M3;6[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTJ{LkOyNlIh|ryP NYn0XI1OW0GQR1XS
KM12 M{nJ[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LkWGlEPTB;MkKuN|U3KM7:TR?= NX7KdGY2W0GQR1XS
JEG-3 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\lVYtuUUN3ME2yNk4{PzhizszN NVrIVFliW0GQR1XS
LN-405 M4\XW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDjTWM2OD1{Mj61PVE{KM7:TR?= M4rsW3NCVkeHUh?=
HCT-15 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJ{Lke0OFEh|ryP MUHTRW5ITVJ?
MLMA MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MluyTWM2OD1{Mj63OFch|ryP NI\w[HFUSU6JRWK=
GI-1 MojkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2riXmlEPTB;MkKuO|Y2QCEQvF2= NID2NHNUSU6JRWK=
RT-112 NFHpdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{OxOmlEPTB;MkKuPFYyPiEQvF2= M1HUeXNCVkeHUh?=
MPP-89 M2\4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{G0dWlEPTB;MkKuPFY3OSEQvF2= MU\TRW5ITVJ?
A3-KAW MmLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;TWmlEPTB;MkOuNVAxOyEQvF2= NH3sOWhUSU6JRWK=
KALS-1 M{i2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjQW5cxUUN3ME2yN{4yPDF2IN88US=> MVLTRW5ITVJ?
SF126 M1\DWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTJ|Lk[5NlQh|ryP M2Dic3NCVkeHUh?=
SiHa NFrkWYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ|LkmzNlch|ryP NV3SbZlzW0GQR1XS
MDA-MB-415 M1zqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP1TWM2OD1{Mz65OFk6KM7:TR?= NWnBSWNVW0GQR1XS
Daoy NWn1bnNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TLdmlEPTB;MkSuNVI3KM7:TR?= M1fR[nNCVkeHUh?=
COR-L23 NEjKVYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU[4[ZZ6UUN3ME2yOE4yPzZ5IN88US=> NUfYXG5ZW0GQR1XS
KG-1 M13LSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXkVIxGUUN3ME2yOE4yQTJ6IN88US=> NXznNXFkW0GQR1XS
L-428 M{TSSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP6WGxNUUN3ME2yOE42PzlzIN88US=> MlHXV2FPT0WU
NCI-H520 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LYV2lEPTB;MkSuPFg3OSEQvF2= M1XURXNCVkeHUh?=
COLO-792 M4DIUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJ3LkK3N|Ih|ryP NFW2XndUSU6JRWK=
NB12 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj3dHNKSzVyPUK1MlI6PDdizszN NHLvcXNUSU6JRWK=
GAK NEXBfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTJ3LkK5OlMh|ryP NGm0VlhUSU6JRWK=
SW780 NHzsS4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ3LkOyOlQh|ryP NGHoTphUSU6JRWK=
GB-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYWwUJd{UUN3ME2yOU41ODZ7IN88US=> NVXYOZFEW0GQR1XS
P12-ICHIKAWA MnfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFOzWXpKSzVyPUK1MlQ4QDVizszN NVHSVYdCW0GQR1XS
NCI-H1651 M3npdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrFe5lKSzVyPUK1MlU6PyEQvF2= MoHUV2FPT0WU
KE-37 NFX5eGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJ3LkezNVUh|ryP MVPTRW5ITVJ?
CCRF-CEM MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnneZNKSzVyPUK1Mlk3PyEQvF2= NIP0UFNUSU6JRWK=
SF295 NIDWcWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHhXnVKSzVyPUK2MlA1OjVizszN MlfZV2FPT0WU
G-361 Mn;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHtem5DUUN3ME2yOk4yODJ5IN88US=> MUXTRW5ITVJ?
HOP-92 NUj5ZodWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTJ4LkGyNlYh|ryP MV7TRW5ITVJ?
UMC-11 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TCPGlEPTB;Mk[uOFUyPCEQvF2= M4nzPXNCVkeHUh?=
IST-SL1 NXrYWYFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe0U2tKSzVyPUK2MlY2QTFizszN MXLTRW5ITVJ?
TE-11 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHXTWM2OD1{Nj63O|UzKM7:TR?= M1zkSHNCVkeHUh?=
NCI-H1304 MlThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ4LkmxNFgh|ryP NYjlTHVKW0GQR1XS
SJSA-1 NWPufGxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TSdWlEPTB;MkeuNFE4PiEQvF2= M3fSNnNCVkeHUh?=
BCPAP NHW3V|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHJcZJKSzVyPUK3MlE{PyEQvF2= M4i5WXNCVkeHUh?=
HTC-C3 M2KzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nxWWlEPTB;MkeuNlU3OSEQvF2= NFvPeZJUSU6JRWK=
EW-16 NH7GWW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJ5LkK5OFch|ryP NVe4XlF6W0GQR1XS
HT-144 M4f1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX0WYx2UUN3ME2yO{41ODN{IN88US=> M2HxWHNCVkeHUh?=
MHH-ES-1 MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGKyOmFKSzVyPUK3MlQ1PDdizszN MnzmV2FPT0WU
T98G NX\Hc3pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXKdplKSzVyPUK3MlU5PDZizszN MXfTRW5ITVJ?
RPMI-8866 NEjaOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJ5Lke1OlIh|ryP NFSyZ5pUSU6JRWK=
BEN Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DGU2lEPTB;MkeuPFUyPyEQvF2= NV3SN25sW0GQR1XS
MDA-MB-231 NEHj[HRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnwTWM2OD1{OD6yO|k2KM7:TR?= MVHTRW5ITVJ?
HuH-7 NHixRnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInw[21KSzVyPUK4MlQxOjhizszN NVPi[3JJW0GQR1XS
SK-N-FI NX7SPJhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\6fZdQUUN3ME2yPE41OzNizszN MUfTRW5ITVJ?
AN3-CA MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXH4[5E1UUN3ME2yPE41Ozl3IN88US=> NV;4[oE3W0GQR1XS
EGI-1 NX60WllRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnriTWM2OD1{OD61PVI5KM7:TR?= M3PPbXNCVkeHUh?=
697 NW\kWGJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33FdGlEPTB;MkiuOlM{OSEQvF2= NYTiNJp3W0GQR1XS
TCCSUP MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnznTWM2OD1{OD62OFE5KM7:TR?= MVfTRW5ITVJ?
GR-ST NGfSbHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXHcI86UUN3ME2yPE43Pjl4IN88US=> MV\TRW5ITVJ?
SK-N-DZ MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ6Lk[4PFUh|ryP NULRZnVRW0GQR1XS
MIA-PaCa-2 NWXzSGVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTJ6Lke5OVkh|ryP NFvVUlBUSU6JRWK=
IGR-1 MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnQTW9KSzVyPUK4Mlg5PzRizszN MX\TRW5ITVJ?
BFTC-905 MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET0dYpKSzVyPUK5MlI4ODVizszN NGnqbVhUSU6JRWK=
NCI-H1581 M1rS[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJ7LkOxOFUh|ryP M1z6d3NCVkeHUh?=
RD NF3KRnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\H[ItiUUN3ME2yPU42OjN|IN88US=> Mn;SV2FPT0WU
SF268 NFfnPHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJ7LkW5N|Eh|ryP NGjWOYRUSU6JRWK=
SHP-77 M3XrTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\UTWM2OD1{OT62NVgzKM7:TR?= NX23TZFWW0GQR1XS
D-566MG MknYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\5TWM2OD1{OT65N|k{KM7:TR?= NWTYTWJpW0GQR1XS
TGBC1TKB NVLGPHZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\JSINNUUN3ME2zNE4yOjN6IN88US=> MVPTRW5ITVJ?
MEL-HO NF3QUVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTNyLkG0NlMh|ryP M3q2NXNCVkeHUh?=
SJRH30 NYfDUpZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjrO5FVUUN3ME2zNE4zOTB6IN88US=> NHLPNm1USU6JRWK=
D-336MG Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDiT41TUUN3ME2zNE4zQDl{IN88US=> M{DVW3NCVkeHUh?=
C3A Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\mNo5kUUN3ME2zNE4zQTJ5IN88US=> NGP0OWpUSU6JRWK=
Calu-6 M3jjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;XWIhGUUN3ME2zNE4zQTZ|IN88US=> M2TDeHNCVkeHUh?=
MZ1-PC NFrscINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DqNmlEPTB;M{CuN|k{KM7:TR?= Ml[wV2FPT0WU
KYSE-70 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmD6TWM2OD1|MD61NVE1KM7:TR?= MnTEV2FPT0WU
CAPAN-1 M37J[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\XeWlEPTB;M{CuOVE5OSEQvF2= NIXYT2RUSU6JRWK=
DK-MG NVHaOpIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\UWFFKSzVyPUOwMlU1PTZizszN NWTNW5oyW0GQR1XS
SK-HEP-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkC1TWM2OD1|MD62N|I3KM7:TR?= NFTKcYFUSU6JRWK=
MS-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;5Um1KSzVyPUOwMlg5QDlizszN MkHxV2FPT0WU
GI-ME-N MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7QeY1KSzVyPUOxMlA2PzFizszN NHyzVG5USU6JRWK=
NCI-H510A MnLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HOXWlEPTB;M{GuOFAxPiEQvF2= NGT6WZJUSU6JRWK=
NB17 Mn3LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrYTmNKSzVyPUOxMlUyQDVizszN MXzTRW5ITVJ?
639-V NV;ibVQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DpUmlEPTB;M{GuOVI1OyEQvF2= M1\4cXNCVkeHUh?=
CAL-51 NGrYflhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XBVWlEPTB;M{GuOVY3PyEQvF2= NFn2eIpUSU6JRWK=
HGC-27 NV73[Jk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljMTWM2OD1|MT61PFc{KM7:TR?= M4nVXXNCVkeHUh?=
GOTO MlrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrWU5JKSzVyPUOxMlg2ODZizszN NEO0dYtUSU6JRWK=
ChaGo-K-1 NIHrUW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTN{LkCwO{DPxE1? NY\E[JNEW0GQR1XS
RO82-W-1 NH;ERZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz5TWM2OD1|Mj6xOlA1KM7:TR?= NWHUcpg4W0GQR1XS
SH-4 MoLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjHPFJKSzVyPUOyMlE5PThizszN NXXse3dsW0GQR1XS
A204 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXjc5JKSzVyPUOyMlUxPjlizszN NIDaV2lUSU6JRWK=
DMS-273 Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXNTWM2OD1|Mj61N|IzKM7:TR?= NUjiUVBSW0GQR1XS
KGN MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjrNJRKSzVyPUOyMlY{OyEQvF2= NWjLOWFwW0GQR1XS
SK-MEL-2 M1LwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjDc5pKSzVyPUOyMlY2OjdizszN MW\TRW5ITVJ?
NCI-H2228 M{X4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN{Lk[2NFIh|ryP M1vSZXNCVkeHUh?=
MKN28 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zJWmlEPTB;M{KuO|g{QCEQvF2= M{\tTnNCVkeHUh?=
H-EMC-SS M37lbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\U[mdxUUN3ME2zNk46Pjd6IN88US=> M4[z[HNCVkeHUh?=
ATN-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGS3O3dKSzVyPUOzMlE1OTZizszN Mm\kV2FPT0WU
D-263MG NEX0UmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlewTWM2OD1|Mz64N|c5KM7:TR?= MWnTRW5ITVJ?
LU-135 NVrMUHVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTN|Lki4Nlkh|ryP MlzaV2FPT0WU
C8166 NF:xXpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjtTWM2OD1|Mz64PFU1KM7:TR?= Ml\HV2FPT0WU
T-24 MlflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFThOW1KSzVyPUO0MlAzODVizszN MlO5V2FPT0WU
Mewo MkTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnuTWM2OD1|ND6xN|Q6KM7:TR?= M2PhNXNCVkeHUh?=
22RV1 MorMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXMTWM2OD1|ND6xO|U1KM7:TR?= NIXlSZVUSU6JRWK=
KM-H2 Ml7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonWTWM2OD1|ND6xO|c6KM7:TR?= MX;TRW5ITVJ?
NCI-H2122 NVOyNW1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1m1UmlEPTB;M{SuN|Q4OSEQvF2= MVzTRW5ITVJ?
ABC-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTN2LkO2PVMh|ryP MW\TRW5ITVJ?
NCI-H1355 M1;HVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTN2LkO4PFkh|ryP M3nIPXNCVkeHUh?=
NOMO-1 M2L0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr0R29KSzVyPUO0MlU4ODNizszN NX\jRmdKW0GQR1XS
MZ7-mel MnL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFKx[lNKSzVyPUO0MlY1QDdizszN NWG1bph[W0GQR1XS
NCI-H810 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHZVZl{UUN3ME2zOE44Ojd6IN88US=> MmPaV2FPT0WU
D-392MG MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmraTWM2OD1|NT6wOVY2KM7:TR?= NWHqfHlZW0GQR1XS
LB771-HNC NF[4[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLEbVFnUUN3ME2zOU4yPjV6IN88US=> NUXlN2cxW0GQR1XS
COLO-679 NWXhN2g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjRdmFPUUN3ME2zOU4{QDhizszN NWTWdXY3W0GQR1XS
SK-PN-DW M{Xvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnnTHZtUUN3ME2zOU41OzZ7IN88US=> NY\jfIdIW0GQR1XS
VA-ES-BJ M{j3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTN3LkS2OFkh|ryP MoryV2FPT0WU
KNS-42 NWnQXHhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnsWXgxUUN3ME2zOU42QDJ4IN88US=> NV\ZPHpWW0GQR1XS
RVH-421 NUPhfWhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfRdoVKSzVyPUO1Mlc3PDVizszN MUXTRW5ITVJ?
P30-OHK MlfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTN3Lki3OVIh|ryP NXfHVolCW0GQR1XS
G-402 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK5TWM2OD1|NT65PFY4KM7:TR?= Mo\jV2FPT0WU
S-117 NETjd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPDVnZKSzVyPUO2MlMxODhizszN NYix[4RuW0GQR1XS
RXF393 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17OWGlEPTB;M{[uN|c5PSEQvF2= MoT5V2FPT0WU
LCLC-103H NGjzPYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHUXYlKSzVyPUO2Mlc5ODNizszN M3zBenNCVkeHUh?=
U-118-MG M4TPOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXviSWc4UUN3ME2zOk45QDR5IN88US=> NFHJfFNUSU6JRWK=
8-MG-BA MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTN4Lkm0PFMh|ryP NUnDblU1W0GQR1XS
MFH-ino Ml;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrHSndZUUN3ME2zO{4{OzdzIN88US=> NFfVemdUSU6JRWK=
NCI-H23 MorTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnWNVJKSzVyPUO3MlQyQTZizszN NX\3d3gyW0GQR1XS
NCI-H446 NVHidJBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vXbmlEPTB;M{euOFg3OiEQvF2= MmLiV2FPT0WU
LU-99A MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN5LkW3N|Eh|ryP M3HNZ3NCVkeHUh?=
KP-N-YN MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVftTZpHUUN3ME2zO{43OTl3IN88US=> NEPR[WtUSU6JRWK=
SCC-9 M{PyOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULPZmNmUUN3ME2zO{44QDN6IN88US=> NHW4e45USU6JRWK=
EFM-19 NVTuPGJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq5UWZkUUN3ME2zO{44QTZ5IN88US=> M4nrTnNCVkeHUh?=
A427 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHW[ZBKSzVyPUO3MlkyODdizszN NUSxeXFEW0GQR1XS
LB831-BLC MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTN6Lk[wN|kh|ryP NFLxd49USU6JRWK=
HOS NGPzRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTjTWM2OD1|OT62Nlc{KM7:TR?= NW[5V41QW0GQR1XS
LAN-6 NVvzRWQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;UTWM2OD12MD6wNVEzKM7:TR?= MWLTRW5ITVJ?
U251 NHjlSGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mne4TWM2OD12MD60NFU1KM7:TR?= NFPDcIpUSU6JRWK=
SNU-387 NVrLR3d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTRyLkS1OVMh|ryP M2C1S3NCVkeHUh?=
DMS-79 NFnTfHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTRyLkW4PFkh|ryP MlfnV2FPT0WU
SK-LU-1 M4K2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe3O2lCUUN3ME20NE43PTZ6IN88US=> Mnv1V2FPT0WU
HT MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXOwXopsUUN3ME20NE43PjN7IN88US=> MnLpV2FPT0WU
KP-N-YS MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jMW2lEPTB;NECuOlc3QCEQvF2= MojCV2FPT0WU
DMS-114 NFTudFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\oTWM2OD12MD64N|c1KM7:TR?= NH\uO2RUSU6JRWK=
HUTU-80 NH70[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHBeXdmUUN3ME20NU4xPTZ7IN88US=> M3\2N3NCVkeHUh?=
ONS-76 NVvZV2VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\T[GlEPTB;NEGuOFcxQSEQvF2= NXHTeI5LW0GQR1XS
A673 NVWxbXZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVq2NHN3UUN3ME20NU42OTV5IN88US=> M4[2THNCVkeHUh?=
HPAF-II MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vDO2lEPTB;NEGuOlcxQSEQvF2= MUHTRW5ITVJ?
UACC-257 NHfOTGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3hNJZNUUN3ME20NU44OzZ7IN88US=> NFG0ZlBUSU6JRWK=
EW-22 M1fVTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnMZVZDUUN3ME20NU45Pjl5IN88US=> NHP2VWdUSU6JRWK=
NCI-H1755 NY\DR|llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfsbFVKSzVyPUSxMlg4OjVizszN NGHPOVBUSU6JRWK=
KYSE-150 M3npemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTR{LkG3PFIh|ryP NH\5XJBUSU6JRWK=
CGTH-W-1 NVTGWVNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrmTWM2OD12Mj60PVU2KM7:TR?= MW\TRW5ITVJ?
NB13 MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjrPFdKSzVyPUSyMlYzOTdizszN NXq2fYxLW0GQR1XS
SW872 MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XGU2lEPTB;NEKuOlM{OSEQvF2= M13rTXNCVkeHUh?=
KP-4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PQWmlEPTB;NEKuPFg{OiEQvF2= M1\wTXNCVkeHUh?=
HCC38 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTaTWM2OD12Mj65OlE5KM7:TR?= MUTTRW5ITVJ?
BB49-HNC NYW3[XFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\iNnpKSzVyPUSzMlI{PTZizszN MW\TRW5ITVJ?
CAL-62 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTZdW5KSzVyPUSzMlQxOjhizszN MVzTRW5ITVJ?
NCI-H2029 M2rDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzWTWM2OD12Mz61OVgyKM7:TR?= MUfTRW5ITVJ?
M14 M4Cx[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTR2LkGzN|Ih|ryP NGqzem1USU6JRWK=
COLO-680N NYfObHJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7k[m1KSzVyPUS0MlM{QSEQvF2= NHTMb5FUSU6JRWK=
Hs-578-T MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPJXXJKSzVyPUS1MlAzQTRizszN M{Phe3NCVkeHUh?=
MSTO-211H NVu0eJBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LyVGlEPTB;NEWuPVQ5OiEQvF2= Mn\rV2FPT0WU
EW-1 M1vQW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17DO2lEPTB;NEWuPVY5QSEQvF2= MYLTRW5ITVJ?
SW948 NFzjdWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonwTWM2OD12Nj60OFYzKM7:TR?= NULkZVBZW0GQR1XS
NCI-H460 MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvmflJKSzVyPUS2MlUzOyEQvF2= MVfTRW5ITVJ?
CAS-1 NFG3NmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPLepJKSzVyPUS2Mlc4ODFizszN NWL4ZZFkW0GQR1XS
TGBC11TKB NGG0WmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTR5LkG3O|ch|ryP MoDBV2FPT0WU
HD-MY-Z M3TJWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTNV|ZzUUN3ME20PE44QDZizszN M4\pOHNCVkeHUh?=
NCI-H226 M1jYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjlTGlpUUN3ME20PU44Pzh3IN88US=> NEjmR2ZUSU6JRWK=
PA-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUmyfVBbUUN3ME20PU45OzN3IN88US=> MX3TRW5ITVJ?
LB2518-MEL NFT4ZpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHnTWM2OD12OT64O|I{KM7:TR?= MUDTRW5ITVJ?
A101D M{L2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;IRmlEPTB;NEmuPVQzPSEQvF2= MVTTRW5ITVJ?
NCI-H2087 M4S2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDUTWM2OD12OT65OlgzKM7:TR?= M3;mTXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

25537503 26052929
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03827070 Recruiting Non Small Cell Lung Cancer Center Trials & Treatment Europe|Center Trials & Treatment March 5 2019 Phase 1
NCT03827070 Recruiting Non Small Cell Lung Cancer Center Trials & Treatment Europe|Center Trials & Treatment March 5 2019 Phase 1
NCT03727724 Active not recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA December 4 2018 Phase 2
NCT03727724 Active not recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA December 4 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

Related EGFR Products4

Tags: buy Afatinib (BIBW2992) | Afatinib (BIBW2992) supplier | purchase Afatinib (BIBW2992) | Afatinib (BIBW2992) cost | Afatinib (BIBW2992) manufacturer | order Afatinib (BIBW2992) | Afatinib (BIBW2992) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID