Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.

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In DMSO USD 240 In stock
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Cited by 74 Publications

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M33kRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G5c2lEPTB;MD6wNFU4OiEQvF2= MXvTRW5ITVJ?
KASUMI-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMEC5NVEh|ryP NHT1OpFUSU6JRWK=
HCC2218 NYLqbHZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rWcGlEPTB;MD6wNFk5PyEQvF2= MmXaV2FPT0WU
KARPAS-45 M3jlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LhSGlEPTB;MD6wNVY4OSEQvF2= MmXNV2FPT0WU
HSC-4 M{L5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnWxTWM2OD1yLkCxO|Q5KM7:TR?= NULRcVJ[W0GQR1XS
CHL-1 M2fXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TVUmlEPTB;MD6wNVg{QSEQvF2= MVfTRW5ITVJ?
KY821 NV3UWY1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4myfWlEPTB;MD6wNlA3KM7:TR?= MUPTRW5ITVJ?
NCI-N87 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEK3O|Mh|ryP M4j3[XNCVkeHUh?=
DOK M4\Lbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEOxPVQh|ryP M{LHfnNCVkeHUh?=
DSH1 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTETWM2OD1yLkCzN|E1KM7:TR?= MlLmV2FPT0WU
MDA-MB-175-VII MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEO0NVYh|ryP NXS3PXQyW0GQR1XS
NCI-H2170 NU\0TYJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTvTWM2OD1yLkCzO|I5KM7:TR?= MWrTRW5ITVJ?
BT-474 M2fSVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;ETWM2OD1yLkC0PVg3KM7:TR?= NGO1NGlUSU6JRWK=
EFO-27 NFT3T3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3nUmRKSzVyPUCuNFUyQDJizszN NI\FfWdUSU6JRWK=
NCI-H720 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj4R4lvUUN3ME2wMlA2OzJ3IN88US=> M4C0S3NCVkeHUh?=
PC-14 Mn\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K1U2lEPTB;MD6wOVY3QCEQvF2= NFrJeVNUSU6JRWK=
EC-GI-10 NXnDT3hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PafmlEPTB;MD6wOVkyOiEQvF2= MnjsV2FPT0WU
KYSE-450 NWPUOJJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEW5O|gh|ryP MWXTRW5ITVJ?
BPH-1 NF7WT21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEW5PFgh|ryP M{mxTXNCVkeHUh?=
NCI-H292 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUG3UXlnUUN3ME2wMlA3ODlizszN M1jqPHNCVkeHUh?=
H9 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPXTWM2OD1yLkC3NVMzKM7:TR?= NF:ySZBUSU6JRWK=
NCI-H526 NXX6fFgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvzcploUUN3ME2wMlA4QDJ|IN88US=> NH[2T3VUSU6JRWK=
NCI-H1623 MnO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMEiwNlUh|ryP MmjDV2FPT0WU
KYSE-140 Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMEizN{DPxE1? NEn6fYpUSU6JRWK=
Ca9-22 NYDUXXk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGL0NI9KSzVyPUCuNFg{PTNizszN MlPYV2FPT0WU
AU565 NEfVdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUOzTo5vUUN3ME2wMlA5PTB2IN88US=> MVTTRW5ITVJ?
ZR-75-30 NXLMNHZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEm1OFUh|ryP NYfNOpBsW0GQR1XS
NCI-H1770 M4D0[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nETGlEPTB;MD6xNFI5KM7:TR?= Mn;iV2FPT0WU
LB2241-RCC NYrCUZlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMUC4PFQh|ryP NW\2Rnp2W0GQR1XS
CAL-39 M4f2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XkeWlEPTB;MD6xNVc6OiEQvF2= NIPNUGNUSU6JRWK=
UACC-893 Mm\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTsbW5KSzVyPUCuNVE5QDVizszN NHnBc|hUSU6JRWK=
LU-65 NH:ydWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDpTWM2OD1yLkGyOlM{KM7:TR?= M2rKPHNCVkeHUh?=
HN MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[zNGZKSzVyPUCuNVMxPzdizszN M361ZnNCVkeHUh?=
TI-73 NWr1Z2pmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMUS3NVUh|ryP NF7RbWVUSU6JRWK=
KU812 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzidnRKSzVyPUCuNVU1PTZizszN M1XmbnNCVkeHUh?=
SW13 NFn3XJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIn0ZpBKSzVyPUCuNVYzOTZizszN NXH0UGtwW0GQR1XS
BB30-HNC MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMU[1O|Yh|ryP M4\pVnNCVkeHUh?=
HSC-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMU[4N|ch|ryP M2LjUXNCVkeHUh?=
BV-173 MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT0[lhKSzVyPUCuNVc2QTZizszN M3z1Z3NCVkeHUh?=
CAL-27 NVXkWG1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvjTWM2OD1yLkG3OlM3KM7:TR?= M2nKd3NCVkeHUh?=
SBC-1 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTS[pZ2UUN3ME2wMlE5QTV7IN88US=> Mnq2V2FPT0WU
CAL-33 NHLSbXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWriTngxUUN3ME2wMlIxOTh2IN88US=> NF3URVFUSU6JRWK=
NCI-H209 NEfD[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fMVWlEPTB;MD6yNFQ3KM7:TR?= NGfDRnNUSU6JRWK=
COR-L105 MkO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TpXGlEPTB;MD6yNVA5PCEQvF2= NH3kfYdUSU6JRWK=
HSC-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\pd40xUUN3ME2wMlIyOTl6IN88US=> NIn0NZFUSU6JRWK=
NCI-H69 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlqwTWM2OD1yLkKxOFUyKM7:TR?= NXrqUHFGW0GQR1XS
MOLT-13 NYPnNnJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTGTWM2OD1yLkKzPVc2KM7:TR?= M1rBb3NCVkeHUh?=
ML-2 NIfQXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFKzTpNKSzVyPUCuNlQ5ODJizszN NV6zd3V4W0GQR1XS
IGROV-1 NF3RWJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S4T2lEPTB;MD6yOVk2OiEQvF2= M1m2[3NCVkeHUh?=
TK10 M37kbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP2Z5R3UUN3ME2wMlI3PzN6IN88US=> MkDPV2FPT0WU
EoL-1-cell M4XXdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnKyTWM2OD1yLkK2PFkzKM7:TR?= NX\ye3dzW0GQR1XS
HO-1-N-1 M{TMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e1UWlEPTB;MD6yO|g2OyEQvF2= M{naPHNCVkeHUh?=
BHY NVnrOGRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojmTWM2OD1yLkK4OlU2KM7:TR?= NFLXZ4NUSU6JRWK=
LU-139 NV7BeGhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPZbGpJUUN3ME2wMlMxPTFizszN Mn64V2FPT0WU
23132-87 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33vOmlEPTB;MD6zNVkzOyEQvF2= NV;0eXYzW0GQR1XS
ACHN M{LGbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzLNWI{UUN3ME2wMlMyQTl2IN88US=> NETtVIhUSU6JRWK=
DoTc2-4510 Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrld3RKSzVyPUCuN|IzOTlizszN MWPTRW5ITVJ?
BB65-RCC NH\HdmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:yTWM2OD1yLkO0OVk{KM7:TR?= NG\0d5NUSU6JRWK=
HLE NVjOboxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLGNopKSzVyPUCuN|UxPDZizszN M3PNNHNCVkeHUh?=
HCC1419 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEP4SHpKSzVyPUCuN|Y1ODhizszN NIfEe3NUSU6JRWK=
A388 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HUXmlEPTB;MD6zOlg2PyEQvF2= NF;2fplUSU6JRWK=
NUGC-3 NGPKSlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\yT2lEPTB;MD6zPFM4OyEQvF2= MlLGV2FPT0WU
KYSE-180 NEPme2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzKVo1JUUN3ME2wMlM6ODh7IN88US=> M1\Yc3NCVkeHUh?=
TE-6 MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mke2TWM2OD1yLkSwNlQ3KM7:TR?= M1PibHNCVkeHUh?=
A498 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\DcW5KSzVyPUCuOFA3PzRizszN MmL2V2FPT0WU
NCI-H1648 NGTab2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwNESxPFIh|ryP M3u3U3NCVkeHUh?=
DU-145 MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu5VXJ2UUN3ME2wMlQ1QDN|IN88US=> Mn61V2FPT0WU
CW-2 M3zHbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO2RpNKSzVyPUCuOFY6OTRizszN MoflV2FPT0WU
A431 NYfDOpN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwNEiyN|Mh|ryP M1XYV3NCVkeHUh?=
SAS M13UNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwNEizPVgh|ryP NITUTGVUSU6JRWK=
NCI-H2126 NYLVNHdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojLTWM2OD1yLkWxPVI3KM7:TR?= NInjNnFUSU6JRWK=
NCI-H358 NGPEW5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PX[GlEPTB;MD61N|IyKM7:TR?= NIHSbZVUSU6JRWK=
FADU MoOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XIdmlEPTB;MD61OFQxPCEQvF2= MV7TRW5ITVJ?
ACN MlH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT5[mpKSzVyPUCuOVUxQTRizszN NELrdGZUSU6JRWK=
HCC70 NGLQRVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojVTWM2OD1yLkW3OlYyKM7:TR?= MV\TRW5ITVJ?
NCI-H1838 NYG4Z2NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorPTWM2OD1yLk[wNlk6KM7:TR?= NUL2cHhGW0GQR1XS
CAL-54 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULGWG0xUUN3ME2wMlYyPjJzIN88US=> MVLTRW5ITVJ?
NCI-H1975 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mke4TWM2OD1yLk[xO|I5KM7:TR?= MlruV2FPT0WU
COR-L88 NHLicXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlq4TWM2OD1yLk[0NVE{KM7:TR?= NV31UmdPW0GQR1XS
CTV-1 NHfMT5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwNkSzPVIh|ryP NUPzOIJXW0GQR1XS
EW-18 M4TRXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TlSmlEPTB;MD62PFY6QCEQvF2= MXLTRW5ITVJ?
HCC1806 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\HWmlEPTB;MD62PVY3PiEQvF2= M1HlcHNCVkeHUh?=
HuP-T4 NWHPO45LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwNkm3OkDPxE1? MlLxV2FPT0WU
MDA-MB-361 M2\6V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XDVmlEPTB;MD63NlY3OiEQvF2= NXfafYdKW0GQR1XS
NCI-H1573 MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnewTWM2OD1yLkezOlMh|ryP M{nOWnNCVkeHUh?=
KU-19-19 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULvVlJKUUN3ME2wMlc4PDZ2IN88US=> NFX1c5FUSU6JRWK=
COLO-678 NFPLXFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;qTWM2OD1yLkiwPFM1KM7:TR?= NYnDbZRQW0GQR1XS
C-33-A NHPTSnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfHRlVpUUN3ME2wMlgyOjl5IN88US=> NF\oWG9USU6JRWK=
Calu-3 M{j6N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwOEG0N|Qh|ryP NGnYWJJUSU6JRWK=
AGS MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVWwbpdiUUN3ME2wMlg{PjR6IN88US=> NEDLRnJUSU6JRWK=
SCC-25 NFXDcm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHqN|hyUUN3ME2wMlg1OTdzIN88US=> M{PlUXNCVkeHUh?=
JVM-2 NVzSfII3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3flSGlEPTB;MD64PFI6QSEQvF2= M1zlbnNCVkeHUh?=
HCE-T M3zUVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTOTWM2OD1yLki4OFI5KM7:TR?= NGTudIZUSU6JRWK=
ES4 NX7wW2lYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3GwWGlEPTB;MD65O|g{PiEQvF2= M1HPV3NCVkeHUh?=
EKVX NYLJO4Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPMTWpKSzVyPUGuNFExPjRizszN MonjV2FPT0WU
D-542MG NVL0ems4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDVTWM2OD1zLkCxNFY1KM7:TR?= M175[nNCVkeHUh?=
SW1116 NVe2ZVI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTFwMEGyPFch|ryP NH\LS3RUSU6JRWK=
5637 NGjye|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLpd4huUUN3ME2xMlAyPTFizszN NV;vbog{W0GQR1XS
HT-1376 NHzib|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTFwMEG1NVMh|ryP Mni4V2FPT0WU
NB69 M3jqSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLX[GRKSzVyPUGuNFI6PDVizszN NHzkT5hUSU6JRWK=
YKG-1 NWDSfYxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rCfmlEPTB;MT6wOVQyQSEQvF2= NV\RfWNKW0GQR1XS
EW-3 NIe2bXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\zTWM2OD1zLkC3PFg{KM7:TR?= MY\TRW5ITVJ?
GCIY NGHsWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnNTWM2OD1zLkC4NVA1KM7:TR?= NH;QSXFUSU6JRWK=
SK-MES-1 NF\keoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnn1TWM2OD1zLkGxOFg4KM7:TR?= NWT6RWlvW0GQR1XS
PANC-08-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3RTWM2OD1zLkG2OFE3KM7:TR?= NFfwSXdUSU6JRWK=
SK-NEP-1 M3vXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjGcVlKSzVyPUGuNVc2OTNizszN M1;pc3NCVkeHUh?=
SW954 NVzqOWJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwMkCyNVQh|ryP M4Dj[HNCVkeHUh?=
NCI-SNU-5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DQd2lEPTB;MT6yN|kh|ryP NEPKU2hUSU6JRWK=
SW48 MojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\GPWlEPTB;MT6yOVQ{OiEQvF2= MVrTRW5ITVJ?
HT-3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HGOWlEPTB;MT6yPFc2OyEQvF2= NXe4NY9jW0GQR1XS
ETK-1 MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTiUmtUUUN3ME2xMlM4PDV4IN88US=> MnfXV2FPT0WU
SCC-15 MkT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTFwM{m0OVEh|ryP MXLTRW5ITVJ?
DU-4475 NIDXXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL4T3hKSzVyPUGuOFAyOjFizszN NYnzZ21XW0GQR1XS
NB5 NWLnXnBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zhfmlEPTB;MT60NVMyPyEQvF2= MlP3V2FPT0WU
CFPAC-1 Mn7hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFW2T3dKSzVyPUGuOFI1QTNizszN MWfTRW5ITVJ?
NCI-H630 NUfOXoNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHf6d5pKSzVyPUGuOFU2QDJizszN Ml3nV2FPT0WU
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D-502MG M3ztemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPDU|NKSzVyPUiuNlkzQDJizszN NUDB[3JSW0GQR1XS
NCI-H1993 Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRThwM{O2N|Eh|ryP MWfTRW5ITVJ?
SCC-4 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NES5W3VKSzVyPUiuOFQxPTlizszN MnraV2FPT0WU
HAL-01 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7WTnNSUUN3ME24MlUyQTFizszN NFv5SpZUSU6JRWK=
GT3TKB NEPqTYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD2cGNKSzVyPUiuOlc6PjRizszN NUPBfINLW0GQR1XS
SK-OV-3 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRThwN{GzNlkh|ryP M3rCUHNCVkeHUh?=
COLO-829 Mor5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRThwOEC5O|Yh|ryP M2rNT3NCVkeHUh?=
OCI-AML2 MkK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TJTGlEPTB;OD65OVQ5OSEQvF2= NELLdodUSU6JRWK=
OS-RC-2 M1r3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7PVFRKSzVyPUmuNFIyQSEQvF2= Ml3LV2FPT0WU
BFTC-909 MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDUS5QzUUN3ME25MlA3Pzl7IN88US=> Mm\OV2FPT0WU
EW-11 NF7xS3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi3UHM2UUN3ME25MlE4PjV|IN88US=> MXzTRW5ITVJ?
HCE-4 MlGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonFTWM2OD17LkKxOVU5KM7:TR?= NY\WNYRTW0GQR1XS
BALL-1 NEDaU21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTlwMkG5NFch|ryP NID5cXFUSU6JRWK=
SF539 NEDzUYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrxcplKSzVyPUmuNlM2PjJizszN MkK5V2FPT0WU
CAMA-1 NXjQfJlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTlwMkixNlgh|ryP MljJV2FPT0WU
C32 NGPNXXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTlwM{OwOlQh|ryP NYTCUpNIW0GQR1XS
NCI-H1703 Ml3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe5TWdKSzVyPUmuN|Q{PzVizszN NWrabZdzW0GQR1XS
NCI-H1650 NYH4Slg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[zfpJvUUN3ME25MlYxQTR4IN88US=> MXLTRW5ITVJ?
NCI-H1563 NIf2Zo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTlwN{[wN|Eh|ryP MVLTRW5ITVJ?
CAL-85-1 M3eyVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmf3TWM2OD17Lki3N|g{KM7:TR?= M1XMVHNCVkeHUh?=
UM-UC-3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPuTWM2OD17Lkm1NFMh|ryP MlfyV2FPT0WU
BxPC-3 Mln5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTFyLkC5O|Ih|ryP NW\NZZFHW0GQR1XS
MHH-PREB-1 M1XuVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTFyLkG5PVkh|ryP NV33eIU1W0GQR1XS
DEL NV23fXI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHUTVhPUUN3ME2xNE4{QTR4IN88US=> MUfTRW5ITVJ?
HuCCT1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TM[mlEPTB;MUCuOlA{OyEQvF2= NYXVVYd2W0GQR1XS
OVCAR-4 NELLdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFyLki4N|Uh|ryP NYq5fnBjW0GQR1XS
CAL-72 NHeyWWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXPTWM2OD1zMD65N|kyKM7:TR?= MmnPV2FPT0WU
HCC1954 MoLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnUSJFFUUN3ME2xNU4xPzV2IN88US=> MV;TRW5ITVJ?
EFO-21 NWrje2loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PydGlEPTB;MUGuNVA1PSEQvF2= MW\TRW5ITVJ?
FTC-133 NVuw[mU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHntN21KSzVyPUGxMlE1ODdizszN M1P6V3NCVkeHUh?=
SK-MEL-24 NWLYdFgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHSbFJKSzVyPUGxMlI{PjZizszN M3;hZXNCVkeHUh?=
UACC-62 MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnGzTWM2OD1zMT6yN|Y5KM7:TR?= M37NNnNCVkeHUh?=
NCI-H650 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnSxTWM2OD1zMT6yOFE5KM7:TR?= NFPieJpUSU6JRWK=
ALL-PO M17TWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvPWVVKSzVyPUGxMlI2OTJizszN NGTUVnZUSU6JRWK=
T84 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjRW|RKSzVyPUGxMlM6ODdizszN NEfK[WpUSU6JRWK=
IST-MEL1 Ml76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPETWM2OD1zMT60OVU6KM7:TR?= MkOxV2FPT0WU
SW626 M2nUcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfjRXVSUUN3ME2xNU42PzV3IN88US=> MYrTRW5ITVJ?
RPMI-2650 MmrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfnNYdKSzVyPUGxMlU5QDVizszN MkPVV2FPT0WU
MC-IXC NFLTc29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T3c2lEPTB;MUGuOlczQCEQvF2= NI\qfXdUSU6JRWK=
HOP-62 M1PXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFzLk[3OlQh|ryP NFXuPJNUSU6JRWK=
NOS-1 NYruUnI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjLTWM2OD1zMT63NVA6KM7:TR?= M1vNc3NCVkeHUh?=
SW1573 NHzjfHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf4W2F6UUN3ME2xNU44Ojl3IN88US=> Ml7YV2FPT0WU
WM-115 NGDNSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PxbWlEPTB;MUGuO|U5QCEQvF2= NILPWoxUSU6JRWK=
HuO9 NHn0bHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfLTWM2OD1zMT64O|c1KM7:TR?= M4TxeHNCVkeHUh?=
YAPC NGPlZ4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XLNmlEPTB;MUGuPVI2QSEQvF2= M13UUHNCVkeHUh?=
MDA-MB-453 NE[yV3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorPTWM2OD1zMT65OVE2KM7:TR?= MnLvV2FPT0WU
NCI-H596 NILtU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DYbGlEPTB;MUKuNFM3QSEQvF2= MVnTRW5ITVJ?
A172 NXfSSXF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTJTWM2OD1zMj6wO|k5KM7:TR?= M1nBdHNCVkeHUh?=
RS4-11 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7jTWM2OD1zMj6xO|I2KM7:TR?= MorQV2FPT0WU
HCC1937 NHzvXYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDlOGJKSzVyPUGyMlc2PjRizszN M3TY[HNCVkeHUh?=
SW837 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTF{LkmwNlgh|ryP M{nJOnNCVkeHUh?=
NMC-G1 NW\uc2M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnPTYtbUUN3ME2xNk46OjN2IN88US=> NGLoUWhUSU6JRWK=
PFSK-1 NWn3WGJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H4c2lEPTB;MUOuNFYh|ryP NWq4XpRDW0GQR1XS
DBTRG-05MG MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P4c2lEPTB;MUOuNFY{OiEQvF2= MXnTRW5ITVJ?
SK-UT-1 NETveXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzpTWM2OD1zMz6xNFg{KM7:TR?= NGLXPWVUSU6JRWK=
OVCAR-5 Mn\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTF|LkG1PVMh|ryP NUTiZWVuW0GQR1XS
8505C NIXsSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF|LkKwOlch|ryP NI\ZVo1USU6JRWK=
SK-MEL-1 M4\Kc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGzTYp[UUN3ME2xN{44OTN3IN88US=> NUDMV2FJW0GQR1XS
LK-2 NYi5c4tVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;Ce2lEPTB;MUOuO|Y{QSEQvF2= NFrWb3BUSU6JRWK=
OE33 M2XkdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv5e3hKSzVyPUGzMlc5PiEQvF2= NXzwZZVPW0GQR1XS
Ramos-2G6-4C10 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojxTWM2OD1zND6wNlAzKM7:TR?= M1TvZnNCVkeHUh?=
EW-13 NGHuVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVewcHhGUUN3ME2xOE4xOzV{IN88US=> NY\oRlNtW0GQR1XS
NCI-H1793 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj1PZpKSzVyPUG0MlIxQDdizszN M37DenNCVkeHUh?=
BHT-101 NXPwWHM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDBN2JKSzVyPUG0MlI1OSEQvF2= NXPITFZHW0GQR1XS
RKO MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTmZVBKSzVyPUG0MlUxPzVizszN M1PPN3NCVkeHUh?=
NEC8 NFXFRphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTF2LkW0O|Ih|ryP NWS1TIF5W0GQR1XS
PANC-10-05 M4PSWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTF2Lk[yOFch|ryP MnH6V2FPT0WU
NCI-H2030 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTF2Lk[0OFgh|ryP M3TZZnNCVkeHUh?=
C2BBe1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF2Lke2OEDPxE1? NHXtVWRUSU6JRWK=
EM-2 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHFNZVXUUN3ME2xOE45PTd4IN88US=> MV3TRW5ITVJ?
HCC1395 Mli2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTF2LkmzN|gh|ryP MlnKV2FPT0WU
A2058 NEPCWFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTF3LkC0NFkh|ryP NIDndnlUSU6JRWK=
SW1463 M2XaPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fTbGlEPTB;MUWuNFQ5PSEQvF2= NYTlUmNSW0GQR1XS
J82 M3fKUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzJc4tKSzVyPUG1MlA2PyEQvF2= MXnTRW5ITVJ?
CAL-120 M1nvb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTF3LkG0OFch|ryP NF71XpdUSU6JRWK=
COLO-824 MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHsTWM2OD1zNT6xOVc6KM7:TR?= MXvTRW5ITVJ?
LNCaP-Clone-FGC MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGxS2hKSzVyPUG1MlQzPDhizszN NF;OUZVUSU6JRWK=
CP66-MEL M17U[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDudIh1UUN3ME2xOU41Pjh6IN88US=> MXzTRW5ITVJ?
OC-314 NFvh[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHSzPXNKSzVyPUG1MlQ4OTRizszN NV3VNYVpW0GQR1XS
OVCAR-8 NFHwbI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfWNWlKSzVyPUG1Mlg5PjFizszN NUmwd2hJW0GQR1XS
MFE-280 NGPHWYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHwTWM2OD1zNj6wOFg5KM7:TR?= NGK5[HBUSU6JRWK=
MHH-NB-11 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkO4TWM2OD1zNj6wPFM6KM7:TR?= M4nEdnNCVkeHUh?=
SW1990 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTF4LkG3OVUh|ryP MUnTRW5ITVJ?
U-266 NI\1XmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTF4LkKyPVkh|ryP M3f6SHNCVkeHUh?=
MFM-223 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PtVWlEPTB;MU[uN|k3PSEQvF2= M{PSSnNCVkeHUh?=
L-363 MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnk[pBlUUN3ME2xOk41PTd5IN88US=> MmTyV2FPT0WU
MCF7 NE\mPZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvsTWM2OD1zNj60O|I{KM7:TR?= NX\BOGJxW0GQR1XS
SK-MEL-3 Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF4LkS3PFch|ryP NVTGSGR{W0GQR1XS
HH MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDkW5F[UUN3ME2xOk42OTZ{IN88US=> MnvYV2FPT0WU
no-10 M3PTTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n6dWlEPTB;MU[uOlM1OyEQvF2= Ml65V2FPT0WU
HuP-T3 M3TKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXsTWM2OD1zNj62OVc3KM7:TR?= MVrTRW5ITVJ?
QIMR-WIL MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jiWmlEPTB;MU[uO|ExPSEQvF2= MWXTRW5ITVJ?
NCI-H1092 NIHwboVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfEXm9KSzVyPUG2Mlg{OTZizszN Mk\KV2FPT0WU
MZ2-MEL MlTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTF4Lki0NFMh|ryP MXnTRW5ITVJ?
ES3 NWTiSppIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;DTWM2OD1zNj65NVM1KM7:TR?= NFnKSZZUSU6JRWK=
COLO-684 Mn[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\XenlqUUN3ME2xOk46PDd5IN88US=> Ml\EV2FPT0WU
NCI-H661 NIHNOZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvoNXhKSzVyPUG2Mlk3QTRizszN MmrLV2FPT0WU
CP50-MEL-B MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\4Xo5KSzVyPUG3MlA{PDNizszN Mkf3V2FPT0WU
NCI-H2405 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPITWM2OD1zNz6xPVc1KM7:TR?= Mon5V2FPT0WU
U-2-OS M3jqfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLETWM2OD1zNz61N|A4KM7:TR?= NIHFd|hUSU6JRWK=
RERF-LC-MS M2fwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnoZWRKSzVyPUG3MlU2ODhizszN MXHTRW5ITVJ?
NCI-H2342 M2D2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzLdJFXUUN3ME2xO{42PTdizszN NE\YN|dUSU6JRWK=
ES8 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:0TWM2OD1zNz62NFg4KM7:TR?= M3jRXHNCVkeHUh?=
MOLT-16 NVjjV4dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrRTWM2OD1zNz64PVM1KM7:TR?= M2PWXHNCVkeHUh?=
RH-18 M2nlSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTF6LkCwN|Uh|ryP M4T1[XNCVkeHUh?=
D-283MED NHPSe5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3KZZVKSzVyPUG4MlAxQDhizszN MoPEV2FPT0WU
RCC10RGB NF\UXotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfzTWM2OD1zOD6wOVU6KM7:TR?= MYDTRW5ITVJ?
NCI-H1437 NH72Z3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTF6LkG2OFEh|ryP NIj3fYpUSU6JRWK=
SW982 M2nEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTF6LkK2O|Eh|ryP MmnFV2FPT0WU
IST-MES1 NGW0VXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPRT3g3UUN3ME2xPE41PDJ6IN88US=> MknyV2FPT0WU
A704 NXjlVo9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnUR|kzUUN3ME2xPE41PzV|IN88US=> NFHCRlNUSU6JRWK=
ESS-1 M2PBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXlSJpKSzVyPUG4MlUzODVizszN NWThZWY5W0GQR1XS
SCH M3HkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTF6Lk[0OVYh|ryP NH6xUXhUSU6JRWK=
COLO-320-HSR Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTF6Lke0OkDPxE1? NFr0SGpUSU6JRWK=
Mo-T MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;VTWM2OD1zOD64NlA1KM7:TR?= M1nnW3NCVkeHUh?=
Saos-2 M{O4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\tOYRLUUN3ME2xPU4yOTZ{IN88US=> MoroV2FPT0WU
SW684 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnxW3NKSzVyPUG5MlE{OjZizszN MWnTRW5ITVJ?
KMOE-2 Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37kPGlEPTB;MUmuNlI1OiEQvF2= MYjTRW5ITVJ?
MMAC-SF MlGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjGVmpKSzVyPUG5MlI3ODdizszN MXnTRW5ITVJ?
JAR MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTF7LkK5PUDPxE1? MYDTRW5ITVJ?
SK-MEL-28 M{n3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTF7LkOzOlMh|ryP NEXBOYFUSU6JRWK=
KNS-81-FD NYi4U4QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\BTWM2OD1zOT61OFY5KM7:TR?= NULTXGROW0GQR1XS
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AsPC-1 MlHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHOTWM2OD1zOT62OFcyKM7:TR?= MXrTRW5ITVJ?
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CAL-51 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;4TWM2OD1|MT61OlY4KM7:TR?= NG\vT3BUSU6JRWK=
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ABC-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;jfWlEPTB;M{SuN|Y6OyEQvF2= NX:3fnRLW0GQR1XS
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MZ7-mel MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLk[JVDUUN3ME2zOE43PDh5IN88US=> NYrx[WxLW0GQR1XS
NCI-H810 M1TCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTN2LkeyO|gh|ryP NXO1[4g3W0GQR1XS
D-392MG NH61UoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XafWlEPTB;M{WuNFU3PSEQvF2= M123UHNCVkeHUh?=
LB771-HNC MlHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\FU4xoUUN3ME2zOU4yPjV6IN88US=> M1HySXNCVkeHUh?=
COLO-679 NI\pdoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PYXWlEPTB;M{WuN|g5KM7:TR?= MmXhV2FPT0WU
SK-PN-DW Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrCS3R1UUN3ME2zOU41OzZ7IN88US=> M3OwdXNCVkeHUh?=
VA-ES-BJ MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7ETWM2OD1|NT60OlQ6KM7:TR?= MVvTRW5ITVJ?
KNS-42 NIftRXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX6TWM2OD1|NT61PFI3KM7:TR?= NIDpWZJUSU6JRWK=
RVH-421 MorvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NET2dmVKSzVyPUO1Mlc3PDVizszN MU\TRW5ITVJ?
P30-OHK M3Wybmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nwUWlEPTB;M{WuPFc2OiEQvF2= MXHTRW5ITVJ?
G-402 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLsTWM2OD1|NT65PFY4KM7:TR?= M1\yd3NCVkeHUh?=
S-117 M1jJXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTN4LkOwNFgh|ryP MoqwV2FPT0WU
RXF393 NG\4OmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XE[GlEPTB;M{[uN|c5PSEQvF2= NXmzSHFOW0GQR1XS
LCLC-103H MlfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW1TWM2OD1|Nj63PFA{KM7:TR?= NIPGNmZUSU6JRWK=
U-118-MG M3HjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYC0dng2UUN3ME2zOk45QDR5IN88US=> MojnV2FPT0WU
8-MG-BA M2jVWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF24ZYNKSzVyPUO2Mlk1QDNizszN NX\v[4R7W0GQR1XS
MFH-ino NHG1RoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7xTWM2OD1|Nz6zN|cyKM7:TR?= Mlz1V2FPT0WU
NCI-H23 MkH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTN5LkSxPVYh|ryP M1zwWnNCVkeHUh?=
NCI-H446 NHHTOHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPmbXFKSzVyPUO3MlQ5PjJizszN MUfTRW5ITVJ?
LU-99A NIT1UWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M124b2lEPTB;M{euOVc{OSEQvF2= MlLrV2FPT0WU
KP-N-YN Mn;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTN5Lk[xPVUh|ryP MYrTRW5ITVJ?
SCC-9 NXfDNGVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTN5Lke4N|gh|ryP NXXZWHViW0GQR1XS
EFM-19 MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fOemlEPTB;M{euO|k3PyEQvF2= MljTV2FPT0WU
A427 NWXzOXVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;BTWM2OD1|Nz65NVA4KM7:TR?= Mn\nV2FPT0WU
LB831-BLC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGzTWM2OD1|OD62NFM6KM7:TR?= MWnTRW5ITVJ?
HOS NVvycpZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PQ[mlEPTB;M{muOlI4OyEQvF2= NFfvdWFUSU6JRWK=
LAN-6 NGX0SZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M162c2lEPTB;NECuNFEyOiEQvF2= M3z4TnNCVkeHUh?=
U251 NYCybZV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HsO2lEPTB;NECuOFA2PCEQvF2= NFHucnlUSU6JRWK=
SNU-387 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTRyLkS1OVMh|ryP MnzaV2FPT0WU
DMS-79 NE[zW2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PxVmlEPTB;NECuOVg5QSEQvF2= M1r4[HNCVkeHUh?=
SK-LU-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe3SJBKSzVyPUSwMlY2PjhizszN MonUV2FPT0WU
HT M{jUfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPNTWM2OD12MD62OlM6KM7:TR?= NVj6[G9nW0GQR1XS
KP-N-YS NULY[3dRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHk[XpKSzVyPUSwMlY4PjhizszN M4W2b3NCVkeHUh?=
DMS-114 M2[weWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXUN5BKSzVyPUSwMlg{PzRizszN NUPBcVlvW0GQR1XS
HUTU-80 MoT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmKyTWM2OD12MT6wOVY6KM7:TR?= NE\YZmFUSU6JRWK=
ONS-76 M3;rfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X1dmlEPTB;NEGuOFcxQSEQvF2= MYLTRW5ITVJ?
A673 NUTaSlB{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz1TWM2OD12MT61NVU4KM7:TR?= NUPnTYx5W0GQR1XS
HPAF-II NFfWNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTRzLk[3NFkh|ryP MVnTRW5ITVJ?
UACC-257 NFO1W2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL4[VdXUUN3ME20NU44OzZ7IN88US=> M3SyT3NCVkeHUh?=
EW-22 NIG1WI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[1S5VKSzVyPUSxMlg3QTdizszN MoDuV2FPT0WU
NCI-H1755 NUXuUolMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTRzLki3NlUh|ryP MUnTRW5ITVJ?
KYSE-150 NVjnWmNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTR{LkG3PFIh|ryP NXXkbno4W0GQR1XS
CGTH-W-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3OyZmlEPTB;NEKuOFk2PSEQvF2= MWDTRW5ITVJ?
NB13 M1:yfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrzSXBKSzVyPUSyMlYzOTdizszN NF3XcFhUSU6JRWK=
SW872 NIrySnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVznTIZJUUN3ME20Nk43OzNzIN88US=> MlL0V2FPT0WU
KP-4 NFGwcYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrYTWM2OD12Mj64PFMzKM7:TR?= NHHmZnNUSU6JRWK=
HCC38 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTR{Lkm2NVgh|ryP M{\OcXNCVkeHUh?=
BB49-HNC NX7LSlEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XBdmlEPTB;NEOuNlM2PiEQvF2= NFLFdZZUSU6JRWK=
CAL-62 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfBUJRKSzVyPUSzMlQxOjhizszN M{\FbXNCVkeHUh?=
NCI-H2029 NVzNcIhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrWbIFmUUN3ME20N{42PThzIN88US=> MXnTRW5ITVJ?
M14 NUfLTZFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPmWWJFUUN3ME20OE4yOzN{IN88US=> NFq0[WZUSU6JRWK=
COLO-680N M{\CTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjR[HJKSzVyPUS0MlM{QSEQvF2= NGHEcVJUSU6JRWK=
Hs-578-T MnznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37FPGlEPTB;NEWuNFI6PCEQvF2= MXvTRW5ITVJ?
MSTO-211H NEKxe2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTR3Lkm0PFIh|ryP MWnTRW5ITVJ?
EW-1 NWHHVYhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTR3Lkm2PFkh|ryP MXXTRW5ITVJ?
SW948 MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHYWmJKUUN3ME20Ok41PDZ{IN88US=> M2f1RnNCVkeHUh?=
NCI-H460 NUnjRW9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUiwR4lGUUN3ME20Ok42OjNizszN MkHIV2FPT0WU
CAS-1 MmLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnr3TWM2OD12Nj63O|AyKM7:TR?= MY\TRW5ITVJ?
TGBC11TKB M1jaVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe5UodKSzVyPUS3MlE4PzdizszN M2\DOHNCVkeHUh?=
HD-MY-Z NHvYSoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PM[WlEPTB;NEiuO|g3KM7:TR?= MUDTRW5ITVJ?
NCI-H226 MmnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfuWXNsUUN3ME20PU44Pzh3IN88US=> M331NnNCVkeHUh?=
PA-1 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofETWM2OD12OT64N|M2KM7:TR?= NXXMR4xNW0GQR1XS
LB2518-MEL NGTZUJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7rXXpQUUN3ME20PU45PzJ|IN88US=> MY\TRW5ITVJ?
A101D Mn\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPqTWM2OD12OT65OFI2KM7:TR?= NHzFRVlUSU6JRWK=
NCI-H2087 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTR7Lkm2PFIh|ryP MkjYV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

25537503 26052929
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03878524 Not yet recruiting Breast Cancer|Prostate Cancer|Pancreatic Cancer|Acute Myelogenous Leukemia OHSU Knight Cancer Institute|Oregon Health and Science University|Prospect Creek Foundation March 14 2019 Phase 1
NCT03827070 Recruiting Non Small Cell Lung Cancer Center Trials & Treatment Europe|Center Trials & Treatment March 5 2019 Phase 1
NCT03827070 Recruiting Non Small Cell Lung Cancer Center Trials & Treatment Europe|Center Trials & Treatment March 5 2019 Phase 1
NCT03727724 Active not recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA December 4 2018 Phase 2
NCT03727724 Active not recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA December 4 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID