Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.

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In DMSO USD 240 In stock
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Cited by 38 Publications

5 Customer Reviews

  • Immunoblot analysis of serum starved H2030 cells pre-treated with 500 nM or 1 µM of gefitinib, crizotinib, CP-724714, or afatinib for 12 hr, followed by stimulation with EGF, HGF, NRG1, or their combination (50 ng/ml) for 10 min.

    Nature, 2016, 534(7609):647-51. Afatinib (BIBW2992) purchased from Selleck.

    Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NEnxcVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHyNolKSzVyPUCuNFA2PzJizszN MWHTRW5ITVJ?
KASUMI-1 NYTC[ZY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMEC5NVEh|ryP MXrTRW5ITVJ?
HCC2218 NX\KU4xpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEC5PFch|ryP NXvz[4h2W0GQR1XS
KARPAS-45 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnFTWM2OD1yLkCxOlcyKM7:TR?= NXr1TVFEW0GQR1XS
HSC-4 NV7CUo1IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vEc2lEPTB;MD6wNVc1QCEQvF2= NHLHZmVUSU6JRWK=
CHL-1 NULnUIo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonnTWM2OD1yLkCxPFM6KM7:TR?= NGTMNXRUSU6JRWK=
KY821 MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f1cGlEPTB;MD6wNlA3KM7:TR?= Mn;iV2FPT0WU
NCI-N87 NV;vRo5RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\jN2lEPTB;MD6wNlc4OyEQvF2= NFvldm1USU6JRWK=
DOK M2fOU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrlb4x3UUN3ME2wMlA{OTl2IN88US=> NHn2XJJUSU6JRWK=
DSH1 NIfGbm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUKxU4FmUUN3ME2wMlA{OzF2IN88US=> NGXHe4hUSU6JRWK=
MDA-MB-175-VII MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPaWGF7UUN3ME2wMlA{PDF4IN88US=> M1zuVHNCVkeHUh?=
NCI-H2170 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEO3Nlgh|ryP MlXPV2FPT0WU
BT-474 M2XEemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMES5PFYh|ryP NXfzWYRkW0GQR1XS
EFO-27 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3uS2QzUUN3ME2wMlA2OTh{IN88US=> MkC3V2FPT0WU
NCI-H720 NUDheYhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIGxOFFKSzVyPUCuNFU{OjVizszN MUPTRW5ITVJ?
PC-14 M{DQ[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XsXGlEPTB;MD6wOVY3QCEQvF2= MWDTRW5ITVJ?
EC-GI-10 MmLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEW5NVIh|ryP M{HnVXNCVkeHUh?=
KYSE-450 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYGxTXdSUUN3ME2wMlA2QTd6IN88US=> M1jFWnNCVkeHUh?=
BPH-1 NGPFcVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXTdYtKSzVyPUCuNFU6QDhizszN MmrMV2FPT0WU
NCI-H292 M3HsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHPN21HUUN3ME2wMlA3ODlizszN M1jqe3NCVkeHUh?=
H9 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[5TWlEPTB;MD6wO|E{OiEQvF2= M4rvPXNCVkeHUh?=
NCI-H526 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HKT2lEPTB;MD6wO|gzOyEQvF2= MXrTRW5ITVJ?
NCI-H1623 NWTLNolRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fsPGlEPTB;MD6wPFAzPSEQvF2= NYXTcXM4W0GQR1XS
KYSE-140 NETVUG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMEizN{DPxE1? MnvZV2FPT0WU
Ca9-22 M165emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHac|VKSzVyPUCuNFg{PTNizszN NECxWXJUSU6JRWK=
AU565 Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwMEi1NFQh|ryP NGDrb4FUSU6JRWK=
ZR-75-30 NILBbJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUKyd3g{UUN3ME2wMlA6PTR3IN88US=> MYjTRW5ITVJ?
NCI-H1770 NVnpdohWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;ac|ZKSzVyPUCuNVAzQCEQvF2= MoK5V2FPT0WU
LB2241-RCC MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y0WWlEPTB;MD6xNFg5PCEQvF2= NHrCS|VUSU6JRWK=
CAL-39 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjlOYw{UUN3ME2wMlEyPzl{IN88US=> M1nFSXNCVkeHUh?=
UACC-893 NFzkcZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DSNmlEPTB;MD6xNVg5PSEQvF2= MV;TRW5ITVJ?
LU-65 M4TIdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrSTWM2OD1yLkGyOlM{KM7:TR?= M{DNS3NCVkeHUh?=
HN NUXUb5M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnweZZ[UUN3ME2wMlE{ODd5IN88US=> NV65PYp1W0GQR1XS
TI-73 MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\JTWM2OD1yLkG0O|E2KM7:TR?= NF;COGpUSU6JRWK=
KU812 M3rybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ntUGlEPTB;MD6xOVQ2PiEQvF2= MnfoV2FPT0WU
SW13 NV;CUpBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMU[yNVYh|ryP NVn1UlJ3W0GQR1XS
BB30-HNC NF\WeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUizXnFpUUN3ME2wMlE3PTd4IN88US=> NVjiWIF{W0GQR1XS
HSC-2 M1jme2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7PUYdKSzVyPUCuNVY5OzdizszN MV3TRW5ITVJ?
BV-173 NHXLRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HpN2lEPTB;MD6xO|U6PiEQvF2= NF\CUndUSU6JRWK=
CAL-27 MoThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mke2TWM2OD1yLkG3OlM3KM7:TR?= MkDaV2FPT0WU
SBC-1 MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7WTWM2OD1yLkG4PVU6KM7:TR?= NH:yfpVUSU6JRWK=
CAL-33 M1e5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGn3dHNKSzVyPUCuNlAyQDRizszN NHvXXo1USU6JRWK=
NCI-H209 M2n2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXrN41KSzVyPUCuNlA1PiEQvF2= NHHxeIdUSU6JRWK=
COR-L105 NFnUfIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnvTWM2OD1yLkKxNFg1KM7:TR?= NVfrdY9VW0GQR1XS
HSC-3 MmnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37FS2lEPTB;MD6yNVE6QCEQvF2= MYTTRW5ITVJ?
NCI-H69 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGKxb|BKSzVyPUCuNlE1PTFizszN NXWwZ4hpW0GQR1XS
MOLT-13 MnvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\jcWVKSzVyPUCuNlM6PzVizszN NHT2ZpBUSU6JRWK=
ML-2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHKzUFFKSzVyPUCuNlQ5ODJizszN M2HJWnNCVkeHUh?=
IGROV-1 NHnWeHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMkW5OVIh|ryP NVLLUIN{W0GQR1XS
TK10 NGPoUmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrGZ21KSzVyPUCuNlY4OzhizszN Ml;2V2FPT0WU
EoL-1-cell MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mom5TWM2OD1yLkK2PFkzKM7:TR?= NVjlfVNiW0GQR1XS
HO-1-N-1 NUDyUI1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHSWYRJUUN3ME2wMlI4QDV|IN88US=> NVnSOYVpW0GQR1XS
BHY MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHjTWM2OD1yLkK4OlU2KM7:TR?= M17KPXNCVkeHUh?=
LU-139 MoH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfzTWM2OD1yLkOwOVEh|ryP MnPCV2FPT0WU
23132-87 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrYTWM2OD1yLkOxPVI{KM7:TR?= MV\TRW5ITVJ?
ACHN NGfuSVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPJeYZKSzVyPUCuN|E6QTRizszN NFrRdINUSU6JRWK=
DoTc2-4510 NVH6[4VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHxbVhmUUN3ME2wMlMzOjF7IN88US=> NVi4TZJFW0GQR1XS
BB65-RCC M{nKTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLQemx7UUN3ME2wMlM1PTl|IN88US=> NUnpTm5mW0GQR1XS
HLE NGWzO3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEGyXHpKSzVyPUCuN|UxPDZizszN NH\icYpUSU6JRWK=
HCC1419 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwM{[0NFgh|ryP MV;TRW5ITVJ?
A388 NWLm[mFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwM{[4OVch|ryP M2PVOXNCVkeHUh?=
NUGC-3 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;Zc|FnUUN3ME2wMlM5Ozd|IN88US=> MlTWV2FPT0WU
KYSE-180 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H0VWlEPTB;MD6zPVA5QSEQvF2= M{Tpb3NCVkeHUh?=
TE-6 MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\tTWM2OD1yLkSwNlQ3KM7:TR?= M3f3NnNCVkeHUh?=
A498 M1q5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjHdW5KSzVyPUCuOFA3PzRizszN MlTmV2FPT0WU
NCI-H1648 M33FTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPoSHlUUUN3ME2wMlQ1OTh{IN88US=> MnjBV2FPT0WU
DU-145 NF\Yd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DENWlEPTB;MD60OFg{OyEQvF2= MWnTRW5ITVJ?
CW-2 MkmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnkVHN1UUN3ME2wMlQ3QTF2IN88US=> MoLLV2FPT0WU
A431 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwNEiyN|Mh|ryP MkjHV2FPT0WU
SAS NU\zd4VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNEizPVgh|ryP M1zHO3NCVkeHUh?=
NCI-H2126 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrP[5BUUUN3ME2wMlUyQTJ4IN88US=> M3W4NHNCVkeHUh?=
NCI-H358 MoX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILIXYxKSzVyPUCuOVMzOSEQvF2= Ml3CV2FPT0WU
FADU NVPVNnpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOwNJZKSzVyPUCuOVQ1ODRizszN MXPTRW5ITVJ?
ACN NXr0fnlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH22WoRKSzVyPUCuOVUxQTRizszN NEDZT49USU6JRWK=
HCC70 MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXJPW4xUUN3ME2wMlU4PjZzIN88US=> M3HsUHNCVkeHUh?=
NCI-H1838 MlPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPoTWM2OD1yLk[wNlk6KM7:TR?= MWLTRW5ITVJ?
CAL-54 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j5[mlEPTB;MD62NVYzOSEQvF2= NEj0c3ZUSU6JRWK=
NCI-H1975 NU[wWpQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjxTWM2OD1yLk[xO|I5KM7:TR?= NG\Bc5lUSU6JRWK=
COR-L88 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmiwTWM2OD1yLk[0NVE{KM7:TR?= NVn0bZFsW0GQR1XS
CTV-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPlTWM2OD1yLk[0N|kzKM7:TR?= NIrBcnVUSU6JRWK=
EW-18 NXr1XmdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXyTWM2OD1yLk[4Olk5KM7:TR?= MX\TRW5ITVJ?
HCC1806 NX3wTJl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfoTWM2OD1yLk[5OlY3KM7:TR?= MlfBV2FPT0WU
HuP-T4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1npNGlEPTB;MD62PVc3KM7:TR?= M12xfnNCVkeHUh?=
MDA-MB-361 NUixTllOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\YNI1sUUN3ME2wMlczPjZ{IN88US=> NXTOXnNiW0GQR1XS
NCI-H1573 M4PCemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX65dotPUUN3ME2wMlc{PjNizszN MYLTRW5ITVJ?
KU-19-19 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2T4XGlEPTB;MD63O|Q3PCEQvF2= MYLTRW5ITVJ?
COLO-678 Mlz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjTeVI5UUN3ME2wMlgxQDN2IN88US=> NYT5Xok{W0GQR1XS
C-33-A NFLzUnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnQO4hKSzVyPUCuPFEzQTdizszN NX3PfW1FW0GQR1XS
Calu-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF31SYhKSzVyPUCuPFE1OzRizszN NXjqVFFKW0GQR1XS
AGS NVPaUGpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHGTWM2OD1yLkizOlQ5KM7:TR?= MU\TRW5ITVJ?
SCC-25 NUPOZ4Y3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XMZ2lEPTB;MD64OFE4OSEQvF2= NGPqO3pUSU6JRWK=
JVM-2 NXf5[3V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr2ZZl1UUN3ME2wMlg5Ojl7IN88US=> NXHYcZZQW0GQR1XS
HCE-T M3jrN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn62TWM2OD1yLki4OFI5KM7:TR?= NYfMfmlDW0GQR1XS
ES4 NW[w[IF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjifYNKSzVyPUCuPVc5OzZizszN M4L2bHNCVkeHUh?=
EKVX NX63Z|JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTFwMEGwOlQh|ryP NFrKZZRUSU6JRWK=
D-542MG MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rOWGlEPTB;MT6wNVA3PCEQvF2= MYDTRW5ITVJ?
SW1116 NUPxeGZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwMEGyPFch|ryP MWHTRW5ITVJ?
5637 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\LTWM2OD1zLkCxOVEh|ryP MYjTRW5ITVJ?
HT-1376 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DGdmlEPTB;MT6wNVUyOyEQvF2= M4\ONnNCVkeHUh?=
NB69 NXnpSFV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTFwMEK5OFUh|ryP NFH6d41USU6JRWK=
YKG-1 NU[0Ooh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2e2TmlEPTB;MT6wOVQyQSEQvF2= Mlj6V2FPT0WU
EW-3 NWL6Ro5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXexWZByUUN3ME2xMlA4QDh|IN88US=> NVvr[VVvW0GQR1XS
GCIY NHnxOXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDHR3JNUUN3ME2xMlA5OTB2IN88US=> M2jKeXNCVkeHUh?=
SK-MES-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3PXHJ7UUN3ME2xMlEyPDh5IN88US=> M1LZbXNCVkeHUh?=
PANC-08-13 M{HERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\TNWlEPTB;MT6xOlQyPiEQvF2= M1TnSHNCVkeHUh?=
SK-NEP-1 M{TrV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nQUWlEPTB;MT6xO|UyOyEQvF2= M{DDbHNCVkeHUh?=
SW954 M2DKZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDMd2JzUUN3ME2xMlIxOjF2IN88US=> NGLrOYVUSU6JRWK=
NCI-SNU-5 NE[zb41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYS4VHVHUUN3ME2xMlI{QSEQvF2= MlXJV2FPT0WU
SW48 MnTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTzTWM2OD1zLkK1OFMzKM7:TR?= NXrydot1W0GQR1XS
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NCI-H28 NELveHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTdwMU[0NFUh|ryP M4GyXHNCVkeHUh?=
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SW900 MoHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[x[WMzUUN3ME23MlgzOTJzIN88US=> MVjTRW5ITVJ?
JVM-3 MnLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPLTWM2OD15Lki5OVk6KM7:TR?= NWPDUHEzW0GQR1XS
OAW-28 M1nmcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{D6fGlEPTB;Nz65OFU4QCEQvF2= NX\zPYdpW0GQR1XS
KURAMOCHI MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGixUZlKSzVyPUeuPVQ5OTFizszN M2\zV3NCVkeHUh?=
BE-13 NF3KbWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfnN5JKSzVyPUeuPVgyOTJizszN MVjTRW5ITVJ?
VMRC-RCZ MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzIT2RKSzVyPUiuNFE3QTdizszN NYKzW4I{W0GQR1XS
NCI-H727 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLkZ3BKSzVyPUiuNVA1OiEQvF2= NF\DSYZUSU6JRWK=
SW1710 NXLBSWI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXP1PFZ[UUN3ME24MlE5PTF3IN88US=> MVTTRW5ITVJ?
D-502MG Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T5ZWlEPTB;OD6yPVI5OiEQvF2= MVjTRW5ITVJ?
NCI-H1993 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRThwM{O2N|Eh|ryP NHjzTopUSU6JRWK=
SCC-4 NGfYPIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[4fnBKSzVyPUiuOFQxPTlizszN Mn;jV2FPT0WU
HAL-01 M3:5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS3TWM2OD16LkWxPVEh|ryP NE\BV|JUSU6JRWK=
GT3TKB MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRThwNke5OlQh|ryP MkDpV2FPT0WU
SK-OV-3 NVTmZXFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;2[4FSUUN3ME24MlcyOzJ7IN88US=> MojXV2FPT0WU
COLO-829 NGiycG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRThwOEC5O|Yh|ryP MofDV2FPT0WU
OCI-AML2 MojyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRThwOUW0PFEh|ryP MkPrV2FPT0WU
OS-RC-2 NUD2NYdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEWzfG9KSzVyPUmuNFIyQSEQvF2= M4jYPXNCVkeHUh?=
BFTC-909 NUTienBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS4S2tKSzVyPUmuNFY4QTlizszN MVfTRW5ITVJ?
EW-11 M1Xue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3YdWRWUUN3ME25MlE4PjV|IN88US=> NYThWHoxW0GQR1XS
HCE-4 M{niOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS0TWM2OD17LkKxOVU5KM7:TR?= NV7VcnBwW0GQR1XS
BALL-1 MoD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTlwMkG5NFch|ryP M17PVXNCVkeHUh?=
SF539 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfmboJvUUN3ME25MlI{PTZ{IN88US=> NGTQVlBUSU6JRWK=
CAMA-1 M3vQWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvsTWM2OD17LkK4NVI5KM7:TR?= NVzDU4E3W0GQR1XS
C32 M{W3W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NID0fJBKSzVyPUmuN|MxPjRizszN NIrGUJNUSU6JRWK=
NCI-H1703 Mn;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITFfXlKSzVyPUmuN|Q{PzVizszN M{XGUHNCVkeHUh?=
NCI-H1650 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPjTWM2OD17Lk[wPVQ3KM7:TR?= M1\pe3NCVkeHUh?=
NCI-H1563 M3LV[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTifVNYUUN3ME25Mlc3ODNzIN88US=> NX7mbHd7W0GQR1XS
CAL-85-1 M3ixdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHUTWM2OD17Lki3N|g{KM7:TR?= M3rSOnNCVkeHUh?=
UM-UC-3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTlwOUWwN{DPxE1? M3Lpe3NCVkeHUh?=
BxPC-3 NV7QeFFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3STWM2OD1zMD6wPVczKM7:TR?= NGHv[JhUSU6JRWK=
MHH-PREB-1 NHOzU5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\Jd|RKUUN3ME2xNE4yQTl7IN88US=> NXnHSFN{W0GQR1XS
DEL MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIGxO3FKSzVyPUGwMlM6PDZizszN M2jTd3NCVkeHUh?=
HuCCT1 NGH0fWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme2TWM2OD1zMD62NFM{KM7:TR?= NW[3e|hvW0GQR1XS
OVCAR-4 NVrqcZNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3YSWEzUUN3ME2xNE45QDN3IN88US=> NX63XmVTW0GQR1XS
CAL-72 NYTOPIx[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTFyLkmzPVEh|ryP MXfTRW5ITVJ?
HCC1954 NUK2N3B5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTWS4dKSzVyPUGxMlA4PTRizszN MYnTRW5ITVJ?
EFO-21 M3TTemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXntOJBFUUN3ME2xNU4yODR3IN88US=> NWXLd|RxW0GQR1XS
FTC-133 MlPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHqTWM2OD1zMT6xOFA4KM7:TR?= NHTTcWFUSU6JRWK=
SK-MEL-24 MoDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFzLkKzOlYh|ryP MV3TRW5ITVJ?
UACC-62 NIOyNIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDITWM2OD1zMT6yN|Y5KM7:TR?= MXPTRW5ITVJ?
NCI-H650 NFjIdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nDc2lEPTB;MUGuNlQyQCEQvF2= NVrZeJZKW0GQR1XS
ALL-PO NYXoUY9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Lhd2lEPTB;MUGuNlUyOiEQvF2= MoHoV2FPT0WU
T84 NF;zfGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUSwbFR1UUN3ME2xNU4{QTB5IN88US=> Ml\nV2FPT0WU
IST-MEL1 NHnBTG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\ETWM2OD1zMT60OVU6KM7:TR?= M3LUOHNCVkeHUh?=
SW626 MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGroN4JKSzVyPUGxMlU4PTVizszN MYfTRW5ITVJ?
RPMI-2650 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTFzLkW4PFUh|ryP MWjTRW5ITVJ?
MC-IXC MmfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIKxWJpKSzVyPUGxMlY4OjhizszN MmH1V2FPT0WU
HOP-62 NFnwN4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK4TWM2OD1zMT62O|Y1KM7:TR?= NGDUOZZUSU6JRWK=
NOS-1 M3fLOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG2ZpZKSzVyPUGxMlcyODlizszN MXjTRW5ITVJ?
SW1573 MnrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PmXmlEPTB;MUGuO|I6PSEQvF2= NHTnNYJUSU6JRWK=
WM-115 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHhTmVKSzVyPUGxMlc2QDhizszN NHzTTXBUSU6JRWK=
HuO9 NHHUc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L5RmlEPTB;MUGuPFc4PCEQvF2= NWS3UZVzW0GQR1XS
YAPC MnLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkO1TWM2OD1zMT65NlU6KM7:TR?= NF3VbXVUSU6JRWK=
MDA-MB-453 NFnud4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvNVnNKSzVyPUGxMlk2OTVizszN NUDEd2RtW0GQR1XS
NCI-H596 NELmeYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTF{LkCzOlkh|ryP MnH5V2FPT0WU
A172 MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzOSIJyUUN3ME2xNk4xPzl6IN88US=> Mn7hV2FPT0WU
RS4-11 NYPjSYR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPBRpNKSzVyPUGyMlE4OjVizszN M1vNbHNCVkeHUh?=
HCC1937 M{DjcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF{Lke1OlQh|ryP MUTTRW5ITVJ?
SW837 NHXWOmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLtcFNKSzVyPUGyMlkxOjhizszN MnfvV2FPT0WU
NMC-G1 NVm0[ZlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvZUpNKSzVyPUGyMlkzOzRizszN NF\RTWxUSU6JRWK=
PFSK-1 MmHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;qc2lEPTB;MUOuNFYh|ryP MUfTRW5ITVJ?
DBTRG-05MG MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULxVlFLUUN3ME2xN{4xPjN{IN88US=> M3S2cXNCVkeHUh?=
SK-UT-1 NFXBSodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jpNWlEPTB;MUOuNVA5OyEQvF2= NYTKelNvW0GQR1XS
OVCAR-5 NWj1Z3BtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTF|LkG1PVMh|ryP NXHTSGl4W0GQR1XS
8505C NVWycpJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2O5XmlEPTB;MUOuNlA3PyEQvF2= M3rwdnNCVkeHUh?=
SK-MEL-1 NGLYXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\XRmlEPTB;MUOuO|E{PSEQvF2= NXnhdI1lW0GQR1XS
LK-2 NWrIPVNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7QVWVKSzVyPUGzMlc3OzlizszN MXPTRW5ITVJ?
OE33 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTF|Lke4OkDPxE1? NH3kV|NUSU6JRWK=
Ramos-2G6-4C10 MnXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnERWNOUUN3ME2xOE4xOjB{IN88US=> NUjNclBiW0GQR1XS
EW-13 NYjYfnVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4qyNmlEPTB;MUSuNFM2OiEQvF2= NYnNU4xSW0GQR1XS
NCI-H1793 NXm0fpVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi3TWM2OD1zND6yNFg4KM7:TR?= M3rjPXNCVkeHUh?=
BHT-101 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TvUGlEPTB;MUSuNlQyKM7:TR?= M1e2RXNCVkeHUh?=
RKO NECz[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jUWmlEPTB;MUSuOVA4PSEQvF2= NWr5b49NW0GQR1XS
NEC8 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTF2LkW0O|Ih|ryP MmLMV2FPT0WU
PANC-10-05 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTF2Lk[yOFch|ryP NWPBfIduW0GQR1XS
NCI-H2030 NVm2VYVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DGbGlEPTB;MUSuOlQ1QCEQvF2= MYTTRW5ITVJ?
C2BBe1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHtVlVKSzVyPUG0Mlc3PCEQvF2= MYjTRW5ITVJ?
EM-2 NEDuT25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTF2Lki1O|Yh|ryP M2THcHNCVkeHUh?=
HCC1395 MorqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF2LkmzN|gh|ryP NUPzflhxW0GQR1XS
A2058 NFm3OY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLxbHF7UUN3ME2xOU4xPDB7IN88US=> MnvGV2FPT0WU
SW1463 MlS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XrUGlEPTB;MUWuNFQ5PSEQvF2= MWTTRW5ITVJ?
J82 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;re2xKSzVyPUG1MlA2PyEQvF2= MWLTRW5ITVJ?
CAL-120 NHG0clRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTF3LkG0OFch|ryP NEDMN2RUSU6JRWK=
COLO-824 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe0[VJKSzVyPUG1MlE2PzlizszN M1zGTHNCVkeHUh?=
LNCaP-Clone-FGC NFr6ZmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF3LkSyOFgh|ryP MW\TRW5ITVJ?
CP66-MEL NXvxWnk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTF3LkS2PFgh|ryP MUfTRW5ITVJ?
OC-314 M4niUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfJdnN5UUN3ME2xOU41PzF2IN88US=> NWXjSJFvW0GQR1XS
OVCAR-8 NH7rUZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFL0XGdKSzVyPUG1Mlg5PjFizszN MXfTRW5ITVJ?
MFE-280 NXWzT4RtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HZV2lEPTB;MU[uNFQ5QCEQvF2= MWTTRW5ITVJ?
MHH-NB-11 M1\aUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXwXnNKSzVyPUG2MlA5OzlizszN MX7TRW5ITVJ?
SW1990 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\yTWM2OD1zNj6xO|U2KM7:TR?= NWO5UHUxW0GQR1XS
U-266 M{T0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\uTWM2OD1zNj6yNlk6KM7:TR?= M{jldXNCVkeHUh?=
MFM-223 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnmTWM2OD1zNj6zPVY2KM7:TR?= MlHKV2FPT0WU
L-363 NWC3bJVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmyTWM2OD1zNj60OVc4KM7:TR?= M{XmPHNCVkeHUh?=
MCF7 NYCzT|dkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4r6PGlEPTB;MU[uOFczOyEQvF2= MoDnV2FPT0WU
SK-MEL-3 NWTyW5o4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz1c|BKSzVyPUG2MlQ4QDdizszN MYLTRW5ITVJ?
HH M4nTemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HSdGlEPTB;MU[uOVE3OiEQvF2= NUSybpg4W0GQR1XS
no-10 NW\5cVY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTF4Lk[zOFMh|ryP NGPaSY9USU6JRWK=
HuP-T3 MljBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DSWmlEPTB;MU[uOlU4PiEQvF2= NFPTTWlUSU6JRWK=
QIMR-WIL NFjnXGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DPeGlEPTB;MU[uO|ExPSEQvF2= NGDqbGVUSU6JRWK=
NCI-H1092 NHvxVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjjTWM2OD1zNj64N|E3KM7:TR?= MUHTRW5ITVJ?
MZ2-MEL MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzKR2psUUN3ME2xOk45PDB|IN88US=> MYjTRW5ITVJ?
ES3 M{TDU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDhTWM2OD1zNj65NVM1KM7:TR?= NImyTVNUSU6JRWK=
COLO-684 NFPB[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGD4V4JKSzVyPUG2Mlk1PzdizszN NH:zbm5USU6JRWK=
NCI-H661 M3nVemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnftTWM2OD1zNj65Olk1KM7:TR?= NYPhOVdGW0GQR1XS
CP50-MEL-B MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm1TWM2OD1zNz6wN|Q{KM7:TR?= NXrOc4NtW0GQR1XS
NCI-H2405 M3\WSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHYcnBKSzVyPUG3MlE6PzRizszN MYjTRW5ITVJ?
U-2-OS MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnzXYVKSzVyPUG3MlU{ODdizszN M{PieXNCVkeHUh?=
RERF-LC-MS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW2TWM2OD1zNz61OVA5KM7:TR?= M{[2dnNCVkeHUh?=
NCI-H2342 NHPrXlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;4bWlEPTB;MUeuOVU4KM7:TR?= NHPTSoVUSU6JRWK=
ES8 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zoN2lEPTB;MUeuOlA5PyEQvF2= MnviV2FPT0WU
MOLT-16 NEK2T4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vTbWlEPTB;MUeuPFk{PCEQvF2= NUHJ[JdOW0GQR1XS
RH-18 M3:4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzCd4ZwUUN3ME2xPE4xODN3IN88US=> NIThWGJUSU6JRWK=
D-283MED M1[ySWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLzOHR1UUN3ME2xPE4xODh6IN88US=> NX33OWE6W0GQR1XS
RCC10RGB NFjGdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zRSGlEPTB;MUiuNFU2QSEQvF2= Mn7TV2FPT0WU
NCI-H1437 NUL0dWRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTMWXNKSzVyPUG4MlE3PDFizszN MVrTRW5ITVJ?
SW982 M1\rTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXMT4FKSzVyPUG4MlI3PzFizszN NFnPNHlUSU6JRWK=
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A704 M1nyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF6LkS3OVMh|ryP Ml60V2FPT0WU
ESS-1 Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTF6LkWyNFUh|ryP NYPCTZhyW0GQR1XS
SCH MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHsZ4tmUUN3ME2xPE43PDV4IN88US=> Ml7XV2FPT0WU
COLO-320-HSR NXHpZ5pYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLQT|ZlUUN3ME2xPE44PDZizszN NFW2XnhUSU6JRWK=
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RPMI-8866 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33QeGlEPTB;MkeuO|U3OiEQvF2= NEfxSY1USU6JRWK=
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HuH-7 MojyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTnd5pUUUN3ME2yPE41ODJ6IN88US=> NXrmNlJzW0GQR1XS
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GR-ST MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S0bWlEPTB;MkiuOlY6PiEQvF2= NIm4UpZUSU6JRWK=
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IGR-1 M1\QW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[4eWQzUUN3ME2yPE45QDd2IN88US=> NXzMc|ZrW0GQR1XS
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T-24 NULRbFc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTN2LkCyNFUh|ryP MWjTRW5ITVJ?
Mewo MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLuTWM2OD1|ND6xN|Q6KM7:TR?= MV7TRW5ITVJ?
22RV1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDlTWM2OD1|ND6xO|U1KM7:TR?= M3Hz[HNCVkeHUh?=
KM-H2 M{fkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;jboJKSzVyPUO0MlE4PzlizszN NHK0V3FUSU6JRWK=
NCI-H2122 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zldmlEPTB;M{SuN|Q4OSEQvF2= MmH4V2FPT0WU
ABC-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe0VGZKSzVyPUO0MlM3QTNizszN MWfTRW5ITVJ?
NCI-H1355 NH3DcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPZTWM2OD1|ND6zPFg6KM7:TR?= NVPDU|hyW0GQR1XS
NOMO-1 NIPaN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW2NoVOUUN3ME2zOE42PzB|IN88US=> NHPCXZlUSU6JRWK=
MZ7-mel Mn\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPQTWM2OD1|ND62OFg4KM7:TR?= MkXTV2FPT0WU
NCI-H810 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LKVmlEPTB;M{SuO|I4QCEQvF2= M{SwV3NCVkeHUh?=
D-392MG NVzpfYs2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\LTWM2OD1|NT6wOVY2KM7:TR?= MYPTRW5ITVJ?
LB771-HNC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTN3LkG2OVgh|ryP M{niOHNCVkeHUh?=
COLO-679 NF;xNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXST3dJUUN3ME2zOU4{QDhizszN NYX4ZYdNW0GQR1XS
SK-PN-DW M4\PSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTN3LkSzOlkh|ryP Mn;OV2FPT0WU
VA-ES-BJ NHfPUVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTtTWM2OD1|NT60OlQ6KM7:TR?= NYrOVmU2W0GQR1XS
KNS-42 MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvlc2ZKSzVyPUO1MlU5OjZizszN NVn4b|FDW0GQR1XS
RVH-421 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\mS4F[UUN3ME2zOU44PjR3IN88US=> NHzVOIpUSU6JRWK=
P30-OHK MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj2dYdKSzVyPUO1Mlg4PTJizszN MVTTRW5ITVJ?
G-402 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MniwTWM2OD1|NT65PFY4KM7:TR?= M1X6N3NCVkeHUh?=
S-117 NI\C[mRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHOTWM2OD1|Nj6zNFA5KM7:TR?= MnziV2FPT0WU
RXF393 M4D1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz4XoVKSzVyPUO2MlM4QDVizszN M3Ti[XNCVkeHUh?=
LCLC-103H M{T3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n5RmlEPTB;M{[uO|gxOyEQvF2= NFrTc4RUSU6JRWK=
U-118-MG M{fGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTN4Lki4OFch|ryP NYPhW3VjW0GQR1XS
8-MG-BA NYjSZ2JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXQSWVKSzVyPUO2Mlk1QDNizszN M{LBeHNCVkeHUh?=
MFH-ino MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu2TWM2OD1|Nz6zN|cyKM7:TR?= M{THPXNCVkeHUh?=
NCI-H23 M{W5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPhTWM2OD1|Nz60NVk3KM7:TR?= Ml\OV2FPT0WU
NCI-H446 MkfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTN5LkS4OlIh|ryP Ml7mV2FPT0WU
LU-99A MkPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTN5LkW3N|Eh|ryP NEK0PWhUSU6JRWK=
KP-N-YN NV;UbIVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHSyPFdKSzVyPUO3MlYyQTVizszN NVrQWFU6W0GQR1XS
SCC-9 NHvqbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXYWmlKSzVyPUO3Mlc5OzhizszN NFH3enlUSU6JRWK=
EFM-19 MlzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTyTWM2OD1|Nz63PVY4KM7:TR?= MnTpV2FPT0WU
A427 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTN5LkmxNFch|ryP NWP2fnhLW0GQR1XS
LB831-BLC NHvJOXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTN6Lk[wN|kh|ryP M1q5SHNCVkeHUh?=
HOS M4\lW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfpc2NvUUN3ME2zPU43Ojd|IN88US=> MnfWV2FPT0WU
LAN-6 M33Zd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTSTWM2OD12MD6wNVEzKM7:TR?= MXzTRW5ITVJ?
U251 NUTTZWs5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTRyLkSwOVQh|ryP MnHjV2FPT0WU
SNU-387 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTRyLkS1OVMh|ryP NXL3ZWhHW0GQR1XS
DMS-79 NFrOdWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nScWlEPTB;NECuOVg5QSEQvF2= M1TDUXNCVkeHUh?=
SK-LU-1 NYL2b5RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TyXmlEPTB;NECuOlU3QCEQvF2= NU\wOYVYW0GQR1XS
HT NHjTflZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{D0XmlEPTB;NECuOlY{QSEQvF2= NH72cHRUSU6JRWK=
KP-N-YS MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nIR2lEPTB;NECuOlc3QCEQvF2= NHnUOZlUSU6JRWK=
DMS-114 NU\mWmwxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPxNZpuUUN3ME20NE45Ozd2IN88US=> M17ZWHNCVkeHUh?=
HUTU-80 M1nlNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTRzLkC1Olkh|ryP NYe0b4p4W0GQR1XS
ONS-76 NX\UeVI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTRzLkS3NFkh|ryP NFHn[2NUSU6JRWK=
A673 Mn\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjybJlJUUN3ME20NU42OTV5IN88US=> NUG2VmNKW0GQR1XS
HPAF-II NF7qO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHjZWpKSzVyPUSxMlY4ODlizszN NELNPINUSU6JRWK=
UACC-257 M1fpUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjUS|FKSzVyPUSxMlc{PjlizszN MmLOV2FPT0WU
EW-22 NVHwZ3E5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTRzLki2PVch|ryP MYLTRW5ITVJ?
NCI-H1755 NHW0OHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjSWldKSzVyPUSxMlg4OjVizszN MX\TRW5ITVJ?
KYSE-150 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\kTWM2OD12Mj6xO|gzKM7:TR?= M1m4U3NCVkeHUh?=
CGTH-W-1 NFzUeIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrKTWozUUN3ME20Nk41QTV3IN88US=> NUHmV5JPW0GQR1XS
NB13 NXrkcmxwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTR{Lk[yNVch|ryP NH\pT|VUSU6JRWK=
SW872 M{PFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHBTWM2OD12Mj62N|MyKM7:TR?= NH3kZYtUSU6JRWK=
KP-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF61UJdKSzVyPUSyMlg5OzJizszN MYPTRW5ITVJ?
HCC38 MkTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVy0SpgyUUN3ME20Nk46PjF6IN88US=> M1LFNXNCVkeHUh?=
BB49-HNC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrPWItGUUN3ME20N{4zOzV4IN88US=> MknOV2FPT0WU
CAL-62 NV\4WpYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnlVnNKSzVyPUSzMlQxOjhizszN MoPTV2FPT0WU
NCI-H2029 M{Pm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLITWM2OD12Mz61OVgyKM7:TR?= NUPOTGNxW0GQR1XS
M14 NGHMSHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\6TWM2OD12ND6xN|MzKM7:TR?= MV;TRW5ITVJ?
COLO-680N NEXC[5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3K5PWlEPTB;NESuN|M6KM7:TR?= NFnEcodUSU6JRWK=
Hs-578-T MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfkTWM2OD12NT6wNlk1KM7:TR?= M4fwc3NCVkeHUh?=
MSTO-211H M1HSZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DBPWlEPTB;NEWuPVQ5OiEQvF2= MXLTRW5ITVJ?
EW-1 NHT2SFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHNeWtKSzVyPUS1Mlk3QDlizszN NH[xWYxUSU6JRWK=
SW948 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7DdnZpUUN3ME20Ok41PDZ{IN88US=> MYXTRW5ITVJ?
NCI-H460 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLrUXlKSzVyPUS2MlUzOyEQvF2= NXTFZ|I4W0GQR1XS
CAS-1 M3jxV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTR4Lke3NFEh|ryP NXXrR4FqW0GQR1XS
TGBC11TKB MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTR5LkG3O|ch|ryP NE\3SpVUSU6JRWK=
HD-MY-Z NY\ZSnRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTR6Lke4OkDPxE1? MoDJV2FPT0WU
NCI-H226 NH35UoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\PT|RLUUN3ME20PU44Pzh3IN88US=> MnfxV2FPT0WU
PA-1 M{PxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvWU29KSzVyPUS5Mlg{OzVizszN M37RcnNCVkeHUh?=
LB2518-MEL NXPZVWpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmH0TWM2OD12OT64O|I{KM7:TR?= MV7TRW5ITVJ?
A101D M3[2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v5UWlEPTB;NEmuPVQzPSEQvF2= M{HpVnNCVkeHUh?=
NCI-H2087 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTJWFdKSzVyPUS5Mlk3QDJizszN MVHTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03727724 Not yet recruiting Carcinoma Non-Small-Cell Lung The Netherlands Cancer Institute|Boehringer Ingelheim|Merck Serono International SA November 2018 Phase 2
NCT03695510 Not yet recruiting Head and Neck Neoplasms National Taiwan University Hospital November 2018 Phase 2
NCT03652233 Not yet recruiting Recurrent Squamous Cell Carcinoma of the Head or Neck|Platinum- and Cetuximab-Refractory Squamous Cell Carcinoma of the Head or Neck|Metastatic Squamous Cell Carcinoma of the Head or Neck|Squamous Cell Carcinoma Vanderbilt-Ingram Cancer Center|National Comprehensive Cancer Network|Boehringer Ingelheim November 2018 Phase 1
NCT03711422 Not yet recruiting Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03574402 Not yet recruiting Carcinoma Non-Small-Cell Lung Guangdong Association of Clinical Trials July 1 2018 Phase 2
NCT03083678 Recruiting Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID