Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.

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Cited by 180 Publications

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVmwUVVNUUN3ME2wMlAxPTd{IN88US=> MmXDV2FPT0WU
KASUMI-1 NU\rfmt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnPTWM2OD1yLkCwPVEyKM7:TR?= MVPTRW5ITVJ?
HCC2218 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEC5PFch|ryP MVPTRW5ITVJ?
KARPAS-45 MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPOTY1KSzVyPUCuNFE3PzFizszN Mn;XV2FPT0WU
HSC-4 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rSOGlEPTB;MD6wNVc1QCEQvF2= MXXTRW5ITVJ?
CHL-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrWXIRKSzVyPUCuNFE5OzlizszN M1\MUnNCVkeHUh?=
KY821 NIHVb2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\NS2RKSzVyPUCuNFIxPiEQvF2= Mlq2V2FPT0WU
NCI-N87 M1nIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHX5RolKSzVyPUCuNFI4PzNizszN MWPTRW5ITVJ?
DOK NXLU[Ip4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXOwS4E3UUN3ME2wMlA{OTl2IN88US=> M{LXPXNCVkeHUh?=
DSH1 M2Dhcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfUTWM2OD1yLkCzN|E1KM7:TR?= MkjnV2FPT0WU
MDA-MB-175-VII NWX3d|JjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHuydJlKSzVyPUCuNFM1OTZizszN NV;PdVl[W0GQR1XS
NCI-H2170 MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMEO3Nlgh|ryP MmfqV2FPT0WU
BT-474 NYXyco1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LOUmlEPTB;MD6wOFk5PiEQvF2= M{nnVHNCVkeHUh?=
EFO-27 M{LGO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rUS2lEPTB;MD6wOVE5OiEQvF2= NI\oPFBUSU6JRWK=
NCI-H720 M{DCZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rGcGlEPTB;MD6wOVMzPSEQvF2= MXXTRW5ITVJ?
PC-14 NIn6OJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYKxbm5UUUN3ME2wMlA2PjZ6IN88US=> MXzTRW5ITVJ?
EC-GI-10 NXHUUWF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnMTXlKSzVyPUCuNFU6OTJizszN MWjTRW5ITVJ?
KYSE-450 M1T0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkToTWM2OD1yLkC1PVc5KM7:TR?= MYPTRW5ITVJ?
BPH-1 NGe3d3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ixd2lEPTB;MD6wOVk5QCEQvF2= MnHXV2FPT0WU
NCI-H292 Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwME[wPUDPxE1? Mo\tV2FPT0WU
H9 NVTBZZJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLrcGRWUUN3ME2wMlA4OTN{IN88US=> NX3yTmJrW0GQR1XS
NCI-H526 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfFcYNSUUN3ME2wMlA4QDJ|IN88US=> MmjTV2FPT0WU
NCI-H1623 NH7sVWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHLfnJoUUN3ME2wMlA5ODJ3IN88US=> NV\CPZJ2W0GQR1XS
KYSE-140 M4LReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\uTWM2OD1yLkC4N|Mh|ryP NI\yXHBUSU6JRWK=
Ca9-22 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMEizOVMh|ryP NVXYbmtYW0GQR1XS
AU565 M3\U[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfxTWM2OD1yLkC4OVA1KM7:TR?= NU\NUYZMW0GQR1XS
ZR-75-30 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHM[WpKSzVyPUCuNFk2PDVizszN NXTCdZZFW0GQR1XS
NCI-H1770 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrGb3RKSzVyPUCuNVAzQCEQvF2= MoL1V2FPT0WU
LB2241-RCC NV2ycGhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlS2TWM2OD1yLkGwPFg1KM7:TR?= M2j3RXNCVkeHUh?=
CAL-39 NIDUeGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33HfGlEPTB;MD6xNVc6OiEQvF2= NYLJVWNZW0GQR1XS
UACC-893 MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnTeoVKSzVyPUCuNVE5QDVizszN Mon4V2FPT0WU
LU-65 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMUK2N|Mh|ryP M4XQTHNCVkeHUh?=
HN M4DKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMUOwO|ch|ryP MXzTRW5ITVJ?
TI-73 Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPFU4M6UUN3ME2wMlE1PzF3IN88US=> Mlv1V2FPT0WU
KU812 NIO4[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMUW0OVYh|ryP M{Pad3NCVkeHUh?=
SW13 M4\mNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnlZYZYUUN3ME2wMlE3OjF4IN88US=> NFTUfmtUSU6JRWK=
BB30-HNC NFPsc29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTwe4lTUUN3ME2wMlE3PTd4IN88US=> MWXTRW5ITVJ?
HSC-2 M2LlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMU[4N|ch|ryP MWLTRW5ITVJ?
BV-173 NEjQVI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljkTWM2OD1yLkG3OVk3KM7:TR?= MVLTRW5ITVJ?
CAL-27 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\aW5dHUUN3ME2wMlE4PjN4IN88US=> MWTTRW5ITVJ?
SBC-1 MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXXTotKSzVyPUCuNVg6PTlizszN NIfaUFhUSU6JRWK=
CAL-33 MkT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LVZ2lEPTB;MD6yNFE5PCEQvF2= NVG3RlNrW0GQR1XS
NCI-H209 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfCTWM2OD1yLkKwOFYh|ryP Mn7QV2FPT0WU
COR-L105 NYHtcHhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT1TWM2OD1yLkKxNFg1KM7:TR?= MmSxV2FPT0WU
HSC-3 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PaTWlEPTB;MD6yNVE6QCEQvF2= M37zcnNCVkeHUh?=
NCI-H69 MlnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nRcGlEPTB;MD6yNVQ2OSEQvF2= M4H0Z3NCVkeHUh?=
MOLT-13 NI\XfmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHQR5hvUUN3ME2wMlI{QTd3IN88US=> MkLEV2FPT0WU
ML-2 M4fjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\STWM2OD1yLkK0PFAzKM7:TR?= NHfuZVhUSU6JRWK=
IGROV-1 M3jQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfJU45KSzVyPUCuNlU6PTJizszN M1fUdnNCVkeHUh?=
TK10 NYLURppbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3XT2VxUUN3ME2wMlI3PzN6IN88US=> M2HPbXNCVkeHUh?=
EoL-1-cell NFm0SWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjxTWM2OD1yLkK2PFkzKM7:TR?= Mnj4V2FPT0WU
HO-1-N-1 M3\kZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfPdopKSzVyPUCuNlc5PTNizszN NYjHc|BbW0GQR1XS
BHY MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMki2OVUh|ryP NV;UZ3ZNW0GQR1XS
LU-139 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwM{C1NUDPxE1? NVvXRoV7W0GQR1XS
23132-87 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4iwXmlEPTB;MD6zNVkzOyEQvF2= MlTkV2FPT0WU
ACHN Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7XU2g5UUN3ME2wMlMyQTl2IN88US=> NGfkVHpUSU6JRWK=
DoTc2-4510 M162ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwM{KyNVkh|ryP M1fCR3NCVkeHUh?=
BB65-RCC NGi4OXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor2TWM2OD1yLkO0OVk{KM7:TR?= NHnTWIRUSU6JRWK=
HLE MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;KTWM2OD1yLkO1NFQ3KM7:TR?= NYXjS|JZW0GQR1XS
HCC1419 M1T0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLPUXdKSzVyPUCuN|Y1ODhizszN MYPTRW5ITVJ?
A388 NVm3SpZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHQTWM2OD1yLkO2PFU4KM7:TR?= MYHTRW5ITVJ?
NUGC-3 NIr2e4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwM{izO|Mh|ryP NXr3RWY4W0GQR1XS
KYSE-180 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwM{mwPFkh|ryP MkHxV2FPT0WU
TE-6 M2HXXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTNeYZSUUN3ME2wMlQxOjR4IN88US=> MXnTRW5ITVJ?
A498 MmXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe0WVlEUUN3ME2wMlQxPjd2IN88US=> M2LTRXNCVkeHUh?=
NCI-H1648 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNESxPFIh|ryP NWHCWnFSW0GQR1XS
DU-145 NUnnWllST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPWTWM2OD1yLkS0PFM{KM7:TR?= M{LYNHNCVkeHUh?=
CW-2 MkPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLoTWM2OD1yLkS2PVE1KM7:TR?= M176[XNCVkeHUh?=
A431 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW1TWM2OD1yLkS4NlM{KM7:TR?= NF;GcVBUSU6JRWK=
SAS MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfhTolKSzVyPUCuOFg{QThizszN MmXPV2FPT0WU
NCI-H2126 NXTZU45bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFm3XJRKSzVyPUCuOVE6OjZizszN M4TGUXNCVkeHUh?=
NCI-H358 NYDCbmhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHf6b5FKSzVyPUCuOVMzOSEQvF2= NF7ReItUSU6JRWK=
FADU Mn;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwNUS0NFQh|ryP M1fteXNCVkeHUh?=
ACN NInFZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL3O5RLUUN3ME2wMlU2ODl2IN88US=> NVvtfFhLW0GQR1XS
HCC70 Mmi0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFu4Zm5KSzVyPUCuOVc3PjFizszN MUnTRW5ITVJ?
NCI-H1838 NVzmb|NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj6T3JMUUN3ME2wMlYxOjl7IN88US=> NG[xPWFUSU6JRWK=
CAL-54 M{nybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzqSo5mUUN3ME2wMlYyPjJzIN88US=> MlnaV2FPT0WU
NCI-H1975 NIrGSXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3RdoJKSzVyPUCuOlE4OjhizszN NEPtWVVUSU6JRWK=
COR-L88 M3\KR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPjUnVKSzVyPUCuOlQyOTNizszN NVvRVlNYW0GQR1XS
CTV-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjpbmQzUUN3ME2wMlY1Ozl{IN88US=> NWj3elc2W0GQR1XS
EW-18 Ml7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\mOHNUUUN3ME2wMlY5Pjl6IN88US=> MnnSV2FPT0WU
HCC1806 M1O4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwNkm2OlYh|ryP NGDYe4pUSU6JRWK=
HuP-T4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnWXIlqUUN3ME2wMlY6PzZizszN MnH6V2FPT0WU
MDA-MB-361 M{PIbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn33TWM2OD1yLkeyOlYzKM7:TR?= Mk[1V2FPT0WU
NCI-H1573 NEfIU5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFyxWnBKSzVyPUCuO|M3OyEQvF2= MnTCV2FPT0WU
KU-19-19 NEnFeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwN{e0OlQh|ryP M4XxWXNCVkeHUh?=
COLO-678 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXObYVKSzVyPUCuPFA5OzRizszN NUK4Sm5IW0GQR1XS
C-33-A MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\6dYVKSzVyPUCuPFEzQTdizszN MXrTRW5ITVJ?
Calu-3 NHjqdY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v5N2lEPTB;MD64NVQ{PCEQvF2= M{LabHNCVkeHUh?=
AGS MnXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTkS|lKSzVyPUCuPFM3PDhizszN M1TDTHNCVkeHUh?=
SCC-25 NHP3RXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33WVGlEPTB;MD64OFE4OSEQvF2= MV\TRW5ITVJ?
JVM-2 NV;MRZpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{ezSGlEPTB;MD64PFI6QSEQvF2= NVXqbmNYW0GQR1XS
HCE-T MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\jdmlEPTB;MD64PFQzQCEQvF2= MYXTRW5ITVJ?
ES4 NYnOOWQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3q5U2lEPTB;MD65O|g{PiEQvF2= MkXyV2FPT0WU
EKVX NF7QR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrYenBKSzVyPUGuNFExPjRizszN MULTRW5ITVJ?
D-542MG NUHW[Y1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHtVZJwUUN3ME2xMlAyODZ2IN88US=> MV;TRW5ITVJ?
SW1116 NUi2RmRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPObGhoUUN3ME2xMlAyOjh5IN88US=> MnTwV2FPT0WU
5637 NEfYN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[5c4NKSzVyPUGuNFE2OSEQvF2= NVnKXoFVW0GQR1XS
HT-1376 NGqyb4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFwMEG1NVMh|ryP MkTOV2FPT0WU
NB69 M2PzT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrrTWM2OD1zLkCyPVQ2KM7:TR?= MVzTRW5ITVJ?
YKG-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnXTWM2OD1zLkC1OFE6KM7:TR?= NV\SclRUW0GQR1XS
EW-3 NYXrZlJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLNTWM2OD1zLkC3PFg{KM7:TR?= MYPTRW5ITVJ?
GCIY NXvGPI5IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH2dIpKSzVyPUGuNFgyODRizszN MWXTRW5ITVJ?
SK-MES-1 Mmr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DjWmlEPTB;MT6xNVQ5PyEQvF2= MmfTV2FPT0WU
PANC-08-13 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jxbGlEPTB;MT6xOlQyPiEQvF2= NUPPc5RPW0GQR1XS
SK-NEP-1 M{TqSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljYTWM2OD1zLkG3OVE{KM7:TR?= NHvFbWZUSU6JRWK=
SW954 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfO[mR5UUN3ME2xMlIxOjF2IN88US=> NWfLNYlqW0GQR1XS
NCI-SNU-5 M1HRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPXXpl7UUN3ME2xMlI{QSEQvF2= NVzzNnhoW0GQR1XS
SW48 NIH6W5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTFwMkW0N|Ih|ryP MljEV2FPT0WU
HT-3 M33uWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXPTWM2OD1zLkK4O|U{KM7:TR?= NFTQWW1USU6JRWK=
ETK-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HpU2lEPTB;MT6zO|Q2PiEQvF2= MoXZV2FPT0WU
SCC-15 MoOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrXNoJKSzVyPUGuN|k1PTFizszN NX6xdnZSW0GQR1XS
DU-4475 Mn7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnriTWM2OD1zLkSwNVIyKM7:TR?= NF:4bHpUSU6JRWK=
NB5 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPSbZdwUUN3ME2xMlQyOzF5IN88US=> NWfzPFEzW0GQR1XS
CFPAC-1 MnfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrSNIpKSzVyPUGuOFI1QTNizszN NEG0OlBUSU6JRWK=
NCI-H630 NYDWfI8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTFwNEW1PFIh|ryP NHHT[4xUSU6JRWK=
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D-502MG NGLvRYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRThwMkmyPFIh|ryP NWnxbJZ[W0GQR1XS
NCI-H1993 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OwPGlEPTB;OD6zN|Y{OSEQvF2= NYjNb2Z1W0GQR1XS
SCC-4 MmHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHZcmV5UUN3ME24MlQ1ODV7IN88US=> NELidZRUSU6JRWK=
HAL-01 NVftZ3BHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRThwNUG5NUDPxE1? MnLEV2FPT0WU
GT3TKB NWW5No84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G1fmlEPTB;OD62O|k3PCEQvF2= MV\TRW5ITVJ?
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COLO-829 NHSyepBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K5OmlEPTB;OD64NFk4PiEQvF2= M3;YUnNCVkeHUh?=
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EW-11 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HjRWlEPTB;OT6xO|Y2OyEQvF2= MUXTRW5ITVJ?
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BALL-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe4O|VPUUN3ME25MlIyQTB5IN88US=> MoPLV2FPT0WU
SF539 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[3OWlEPTB;OT6yN|U3OiEQvF2= NI\xdIpUSU6JRWK=
CAMA-1 NH7U[29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m5[WlEPTB;OT6yPFEzQCEQvF2= M3HJT3NCVkeHUh?=
C32 NFrpNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi5THlKSzVyPUmuN|MxPjRizszN MXjTRW5ITVJ?
NCI-H1703 MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfyTWM2OD17LkO0N|c2KM7:TR?= MUPTRW5ITVJ?
NCI-H1650 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HCRmlEPTB;OT62NFk1PiEQvF2= M1TVSHNCVkeHUh?=
NCI-H1563 M{Lid2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1z0cWlEPTB;OT63OlA{OSEQvF2= NXTafppXW0GQR1XS
CAL-85-1 M{T1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXqTWM2OD17Lki3N|g{KM7:TR?= MoXZV2FPT0WU
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MHH-PREB-1 M3HF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFyLkG5PVkh|ryP NIPBS|BUSU6JRWK=
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HuCCT1 NEfk[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTFyLk[wN|Mh|ryP MXrTRW5ITVJ?
OVCAR-4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjpTWM2OD1zMD64PFM2KM7:TR?= NYGx[Yl{W0GQR1XS
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UACC-62 NXrXO3ltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vPb2lEPTB;MUGuNlM3QCEQvF2= NXzSfGZkW0GQR1XS
NCI-H650 MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7ST2ZVUUN3ME2xNU4zPDF6IN88US=> NIfCbZFUSU6JRWK=
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T84 NH\lZ5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljsTWM2OD1zMT6zPVA4KM7:TR?= NE\EVGlUSU6JRWK=
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SW626 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fTOGlEPTB;MUGuOVc2PSEQvF2= MoL1V2FPT0WU
RPMI-2650 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTEelQzUUN3ME2xNU42QDh3IN88US=> MYjTRW5ITVJ?
MC-IXC NX;MOI5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Pwd2lEPTB;MUGuOlczQCEQvF2= M{n2dXNCVkeHUh?=
HOP-62 NHHqUJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rDTGlEPTB;MUGuOlc3PCEQvF2= MmPoV2FPT0WU
NOS-1 M4DrcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\1S2lEPTB;MUGuO|ExQSEQvF2= NEDtXWxUSU6JRWK=
SW1573 NHTIe4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTFzLkeyPVUh|ryP Mo\KV2FPT0WU
WM-115 MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELEZoJKSzVyPUGxMlc2QDhizszN MmfiV2FPT0WU
HuO9 M3\NNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrnTWM2OD1zMT64O|c1KM7:TR?= M{DlWHNCVkeHUh?=
YAPC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDwTWM2OD1zMT65NlU6KM7:TR?= MYnTRW5ITVJ?
MDA-MB-453 M3PVbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHj0PFFKSzVyPUGxMlk2OTVizszN MnryV2FPT0WU
NCI-H596 NUTGV3cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTF{LkCzOlkh|ryP M4\JVHNCVkeHUh?=
A172 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXjfY1iUUN3ME2xNk4xPzl6IN88US=> MorpV2FPT0WU
RS4-11 M12yWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHzTWM2OD1zMj6xO|I2KM7:TR?= MlH0V2FPT0WU
HCC1937 NGjQdYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf1d|VQUUN3ME2xNk44PTZ2IN88US=> MlzXV2FPT0WU
SW837 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTF{LkmwNlgh|ryP NXrZPJA2W0GQR1XS
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DBTRG-05MG M2naPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfoT3ZHUUN3ME2xN{4xPjN{IN88US=> Ml\3V2FPT0WU
SK-UT-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TOfmlEPTB;MUOuNVA5OyEQvF2= MkfiV2FPT0WU
OVCAR-5 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTw[3lVUUN3ME2xN{4yPTl|IN88US=> MkfSV2FPT0WU
8505C MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTF|LkKwOlch|ryP M1;3OHNCVkeHUh?=
SK-MEL-1 NF;TXZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn6RppNUUN3ME2xN{44OTN3IN88US=> MXTTRW5ITVJ?
LK-2 NX\4[3F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTF|Lke2N|kh|ryP MUnTRW5ITVJ?
OE33 NUny[I5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTF|Lke4OkDPxE1? NVy2UnNrW0GQR1XS
Ramos-2G6-4C10 M3W5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PtWGlEPTB;MUSuNFIxOiEQvF2= NFy2WXdUSU6JRWK=
EW-13 M1HjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTFTWM2OD1zND6wN|UzKM7:TR?= NX3ObFVlW0GQR1XS
NCI-H1793 NVfWdZBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTF2LkKwPFch|ryP M{jiXHNCVkeHUh?=
BHT-101 NGDwZ5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPITWM2OD1zND6yOFEh|ryP M3LVV3NCVkeHUh?=
RKO NVrNdml2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Xhd2lEPTB;MUSuOVA4PSEQvF2= MUHTRW5ITVJ?
NEC8 MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrlTWM2OD1zND61OFczKM7:TR?= NXXlXG9RW0GQR1XS
PANC-10-05 M3PMRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTF2Lk[yOFch|ryP MYDTRW5ITVJ?
NCI-H2030 NWTqeYtiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rqRWlEPTB;MUSuOlQ1QCEQvF2= NXrjPVNJW0GQR1XS
C2BBe1 NFywcHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTF2Lke2OEDPxE1? M2noTHNCVkeHUh?=
EM-2 Mkj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTF2Lki1O|Yh|ryP NHr4NXBUSU6JRWK=
HCC1395 MnHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C3TmlEPTB;MUSuPVM{QCEQvF2= M{XJS3NCVkeHUh?=
A2058 M1S4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPoTWM2OD1zNT6wOFA6KM7:TR?= MkTBV2FPT0WU
SW1463 M4jQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXTPZB2UUN3ME2xOU4xPDh3IN88US=> NFuz[4hUSU6JRWK=
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COLO-824 NXzF[4JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HlNmlEPTB;MUWuNVU4QSEQvF2= M3nYdHNCVkeHUh?=
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OVCAR-8 M4PpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\0bJFKSzVyPUG1Mlg5PjFizszN NVPwVIM6W0GQR1XS
MFE-280 MoX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;hTWM2OD1zNj6wOFg5KM7:TR?= M2f5O3NCVkeHUh?=
MHH-NB-11 NY[3OFFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;BdWlEPTB;MU[uNFg{QSEQvF2= MX;TRW5ITVJ?
SW1990 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDSRm9DUUN3ME2xOk4yPzV3IN88US=> NIWwblhUSU6JRWK=
U-266 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\nUoFPUUN3ME2xOk4zOjl7IN88US=> MWrTRW5ITVJ?
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HH NEixUGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnoTWM2OD1zNj61NVYzKM7:TR?= MnjJV2FPT0WU
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NCI-H1092 NH3kO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPTS|hHUUN3ME2xOk45OzF4IN88US=> MXXTRW5ITVJ?
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NCI-H2342 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7ZTWM2OD1zNz61OVch|ryP MlHiV2FPT0WU
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Mo-T MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLqd3o4UUN3ME2xPE45OjB2IN88US=> M2T1W3NCVkeHUh?=
Saos-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTF7LkGxOlIh|ryP MYrTRW5ITVJ?
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IGR-1 M4HoXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv0dVJKUUN3ME2yPE45QDd2IN88US=> NVrqWXlSW0GQR1XS
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NCI-H1581 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzz[Y9IUUN3ME2yPU4{OTR3IN88US=> Mn7tV2FPT0WU
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NCI-H1355 NGDEc2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXiZoVKSzVyPUO0MlM5QDlizszN MWDTRW5ITVJ?
NOMO-1 NXX6SocyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkK0TWM2OD1|ND61O|A{KM7:TR?= M{XUTHNCVkeHUh?=
MZ7-mel M1WzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIna[HlKSzVyPUO0MlY1QDdizszN NFjNWpNUSU6JRWK=
NCI-H810 NH;XRZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfBRXBKSzVyPUO0MlczPzhizszN NV\od5NyW0GQR1XS
D-392MG MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y4eGlEPTB;M{WuNFU3PSEQvF2= MUXTRW5ITVJ?
LB771-HNC NFfaOolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Du[2lEPTB;M{WuNVY2QCEQvF2= NUjH[VExW0GQR1XS
COLO-679 M3:wcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWmxVlV2UUN3ME2zOU4{QDhizszN MUfTRW5ITVJ?
SK-PN-DW MoDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTN3LkSzOlkh|ryP MWXTRW5ITVJ?
VA-ES-BJ MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HscGlEPTB;M{WuOFY1QSEQvF2= NHf6e5hUSU6JRWK=
KNS-42 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFT3boRKSzVyPUO1MlU5OjZizszN NIPkSlNUSU6JRWK=
RVH-421 Mme3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37NcWlEPTB;M{WuO|Y1PSEQvF2= MlXMV2FPT0WU
P30-OHK M3ewPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f4emlEPTB;M{WuPFc2OiEQvF2= MlLVV2FPT0WU
G-402 NEHnRWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTN3Lkm4Olch|ryP NHvWVpNUSU6JRWK=
S-117 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnJS|hWUUN3ME2zOk4{ODB6IN88US=> MW\TRW5ITVJ?
RXF393 M2Xie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi5TWM2OD1|Nj6zO|g2KM7:TR?= NHfMeXZUSU6JRWK=
LCLC-103H MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfDO2s6UUN3ME2zOk44QDB|IN88US=> M1rKZXNCVkeHUh?=
U-118-MG MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\wWJhwUUN3ME2zOk45QDR5IN88US=> NX;vepZYW0GQR1XS
8-MG-BA NFrHW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVv3V2V7UUN3ME2zOk46PDh|IN88US=> M17VWHNCVkeHUh?=
MFH-ino MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTN5LkOzO|Eh|ryP MYnTRW5ITVJ?
NCI-H23 NEL0fFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzB[JZnUUN3ME2zO{41OTl4IN88US=> MlHKV2FPT0WU
NCI-H446 M1;DV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIW2SlFKSzVyPUO3MlQ5PjJizszN Mn;IV2FPT0WU
LU-99A MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTN5LkW3N|Eh|ryP NWmy[WRFW0GQR1XS
KP-N-YN NXHZfYZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37tRWlEPTB;M{euOlE6PSEQvF2= MXTTRW5ITVJ?
SCC-9 M4r6S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv2UIM5UUN3ME2zO{44QDN6IN88US=> NWPURmFuW0GQR1XS
EFM-19 M{G5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTVT|ZWUUN3ME2zO{44QTZ5IN88US=> NE\ybVFUSU6JRWK=
A427 MmLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTN5LkmxNFch|ryP NGTnc4NUSU6JRWK=
LB831-BLC MknxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTN6Lk[wN|kh|ryP M3vQenNCVkeHUh?=
HOS MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTN7Lk[yO|Mh|ryP NIjwbo1USU6JRWK=
LAN-6 NF\5[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTRyLkCxNVIh|ryP MUjTRW5ITVJ?
U251 M{DDVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DBXmlEPTB;NECuOFA2PCEQvF2= MmLYV2FPT0WU
SNU-387 Mn76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3H2d2lEPTB;NECuOFU2OyEQvF2= M1nRSXNCVkeHUh?=
DMS-79 NGDkRVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn4S5BKSzVyPUSwMlU5QDlizszN NGHJOFNUSU6JRWK=
SK-LU-1 MoPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXVOmtKSzVyPUSwMlY2PjhizszN NIXCd2lUSU6JRWK=
HT MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTRyLk[2N|kh|ryP M4DlXnNCVkeHUh?=
KP-N-YS NVP6cXdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDOclhWUUN3ME20NE43PzZ6IN88US=> Ml\iV2FPT0WU
DMS-114 NXTZSmk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fqPWlEPTB;NECuPFM4PCEQvF2= M3LqUXNCVkeHUh?=
HUTU-80 M{n2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTRzLkC1Olkh|ryP NYrNNZRKW0GQR1XS
ONS-76 NIDnUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf3UYpqUUN3ME20NU41PzB7IN88US=> MX\TRW5ITVJ?
A673 NHTHPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTRzLkWxOVch|ryP NX\D[nA4W0GQR1XS
HPAF-II MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTRzLk[3NFkh|ryP M2TaS3NCVkeHUh?=
UACC-257 Mnm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYX0bm91UUN3ME20NU44OzZ7IN88US=> NEHJZpFUSU6JRWK=
EW-22 M2jLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTRzLki2PVch|ryP M{DNVnNCVkeHUh?=
NCI-H1755 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7MTWM2OD12MT64O|I2KM7:TR?= NGHFUldUSU6JRWK=
KYSE-150 NEKyeYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn4fVVKSzVyPUSyMlE4QDJizszN NUPqOHVbW0GQR1XS
CGTH-W-1 M3fuOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjBWnQxUUN3ME20Nk41QTV3IN88US=> MW\TRW5ITVJ?
NB13 NE\1clRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfVTWM2OD12Mj62NlE4KM7:TR?= MmD5V2FPT0WU
SW872 M1zNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjyTWM2OD12Mj62N|MyKM7:TR?= M{DJ[nNCVkeHUh?=
KP-4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknVTWM2OD12Mj64PFMzKM7:TR?= MXPTRW5ITVJ?
HCC38 Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTR{Lkm2NVgh|ryP MYXTRW5ITVJ?
BB49-HNC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfsTWM2OD12Mz6yN|U3KM7:TR?= NFnueYxUSU6JRWK=
CAL-62 MkLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTR|LkSwNlgh|ryP NEHn[YJUSU6JRWK=
NCI-H2029 NXLXPW5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PRNGlEPTB;NEOuOVU5OSEQvF2= MULTRW5ITVJ?
M14 Mlq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln6TWM2OD12ND6xN|MzKM7:TR?= NITRO5VUSU6JRWK=
COLO-680N Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTR2LkOzPUDPxE1? MWrTRW5ITVJ?
Hs-578-T NI\1NFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n1emlEPTB;NEWuNFI6PCEQvF2= MUfTRW5ITVJ?
MSTO-211H NUDJOXZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PXOWlEPTB;NEWuPVQ5OiEQvF2= MUXTRW5ITVJ?
EW-1 MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTR3Lkm2PFkh|ryP NGDOT2JUSU6JRWK=
SW948 MnrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTR4LkS0OlIh|ryP NW\BNlhHW0GQR1XS
NCI-H460 NXTubGdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DBUmlEPTB;NE[uOVI{KM7:TR?= NX7TbGZzW0GQR1XS
CAS-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj1bWU5UUN3ME20Ok44PzBzIN88US=> M2e2RnNCVkeHUh?=
TGBC11TKB MoHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[1WGlEPTB;NEeuNVc4PyEQvF2= NF;mVopUSU6JRWK=
HD-MY-Z MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTR6Lke4OkDPxE1? NWX4bWlqW0GQR1XS
NCI-H226 MkP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHONo5XUUN3ME20PU44Pzh3IN88US=> M3[5fHNCVkeHUh?=
PA-1 NG\1fJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTR7LkizN|Uh|ryP MWnTRW5ITVJ?
LB2518-MEL M1KxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTR7Lki3NlMh|ryP MXXTRW5ITVJ?
A101D NVnE[Jl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;YToVsUUN3ME20PU46PDJ3IN88US=> M1O2R3NCVkeHUh?=
NCI-H2087 Mnj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnhfWhKSzVyPUS5Mlk3QDJizszN NUPOfHFpW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

p-VEGFR2 / VEGFR2 / JAG1 / DLL4 / NICD1 ; 

PubMed: 28533486     


HUVECs were cultured in the presence of Vatalanib (100 nM) or DBZ (10 nM) for 1 h and then treated for 15 min with rhgal-3 (37 nM) and cultured for additional 6 hrs. After this period, the total protein was isolated and the protein levels of galectin-3, NICD1, DLL4, JAG1, VEGFR2 and VEGFR2-p were assessed by Western blot. β-actin was used as a loading control.

25537503 26052929 28533486
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

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In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

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  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03711422 Not yet recruiting Drug: Afatinib Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03083678 Recruiting Drug: Afatinib Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2
NCT03370770 Active not recruiting Drug: Afatinib|Drug: Osimertinib Carcinoma Non-Small-Cell Lung Boehringer Ingelheim December 28 2017 --
NCT02423525 Recruiting Drug: Afatinib Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute December 2016 Phase 1
NCT02695290 Terminated Drug: Afatinib Carcinoma Non-Small-Cell Lung|ErbB Receptors Boehringer Ingelheim March 17 2016 Phase 4
NCT02171741 Completed Drug: BIBW 2992|Drug: Docetaxel Neoplasms Boehringer Ingelheim April 2005 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID