Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.

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In DMSO USD 240 In stock
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Cited by 98 Publications

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M13FcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPFTWM2OD1yLkCwOVczKM7:TR?= NEnxPXZUSU6JRWK=
KASUMI-1 NFXGZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlOzTWM2OD1yLkCwPVEyKM7:TR?= NXfXcpZCW0GQR1XS
HCC2218 NX7PU3VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\wTWM2OD1yLkCwPVg4KM7:TR?= NWry[FhxW0GQR1XS
KARPAS-45 NVfhTFd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmr5TWM2OD1yLkCxOlcyKM7:TR?= NFe2bY1USU6JRWK=
HSC-4 NEfn[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDOTWM2OD1yLkCxO|Q5KM7:TR?= M37hfnNCVkeHUh?=
CHL-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTYeIY5UUN3ME2wMlAyQDN7IN88US=> M4LNT3NCVkeHUh?=
KY821 NF3oU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXWN49ZUUN3ME2wMlAzODZizszN MWHTRW5ITVJ?
NCI-N87 Mn7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DWWGlEPTB;MD6wNlc4OyEQvF2= M{fzcXNCVkeHUh?=
DOK MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLV[|JOUUN3ME2wMlA{OTl2IN88US=> MoPSV2FPT0WU
DSH1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYf4NYRiUUN3ME2wMlA{OzF2IN88US=> NI\3TnlUSU6JRWK=
MDA-MB-175-VII NEjQOoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEO0NVYh|ryP NW\Uc4JzW0GQR1XS
NCI-H2170 NH7mUpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljpTWM2OD1yLkCzO|I5KM7:TR?= MXzTRW5ITVJ?
BT-474 MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrjUnZKSzVyPUCuNFQ6QDZizszN NEnvcoxUSU6JRWK=
EFO-27 NFTsPHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmj3TWM2OD1yLkC1NVgzKM7:TR?= MnLQV2FPT0WU
NCI-H720 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu0RnYzUUN3ME2wMlA2OzJ3IN88US=> Ml;nV2FPT0WU
PC-14 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwMEW2Olgh|ryP NELqT3lUSU6JRWK=
EC-GI-10 MnjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLFW2lKSzVyPUCuNFU6OTJizszN M{T2VXNCVkeHUh?=
KYSE-450 NYnjRmRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLV[ZVIUUN3ME2wMlA2QTd6IN88US=> NH;LfmdUSU6JRWK=
BPH-1 NVnMdo9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\QdWlEPTB;MD6wOVk5QCEQvF2= NWHDU4RTW0GQR1XS
NCI-H292 M3[0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHxTWM2OD1yLkC2NFkh|ryP M{LsSHNCVkeHUh?=
H9 NUXqWYdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33COWlEPTB;MD6wO|E{OiEQvF2= NGS0[WFUSU6JRWK=
NCI-H526 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPVTWM2OD1yLkC3PFI{KM7:TR?= NW\WV3BqW0GQR1XS
NCI-H1623 NXPKTW5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3mUpk6UUN3ME2wMlA5ODJ3IN88US=> M3PJbnNCVkeHUh?=
KYSE-140 NXjrOWFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV74VmRFUUN3ME2wMlA5OzNizszN NFHqb4dUSU6JRWK=
Ca9-22 NF\zOmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\LcmlEPTB;MD6wPFM2OyEQvF2= MmHsV2FPT0WU
AU565 MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMEi1NFQh|ryP MW\TRW5ITVJ?
ZR-75-30 M2S3Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[xTWM2OD1yLkC5OVQ2KM7:TR?= Mk\QV2FPT0WU
NCI-H1770 MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHmTWM2OD1yLkGwNlgh|ryP MYTTRW5ITVJ?
LB2241-RCC NIK2VGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjHd|ZHUUN3ME2wMlExQDh2IN88US=> MVrTRW5ITVJ?
CAL-39 M1r1VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j1c2lEPTB;MD6xNVc6OiEQvF2= M{\oUHNCVkeHUh?=
UACC-893 NEC1WYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP0ZlRKSzVyPUCuNVE5QDVizszN MVjTRW5ITVJ?
LU-65 NHrLd|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMUK2N|Mh|ryP NYK4R3M3W0GQR1XS
HN NEnxUlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHHTWM2OD1yLkGzNFc4KM7:TR?= Ml33V2FPT0WU
TI-73 M3\6WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7uTJJKSzVyPUCuNVQ4OTVizszN NEWyXpVUSU6JRWK=
KU812 Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvPU2p6UUN3ME2wMlE2PDV4IN88US=> NIHWd5FUSU6JRWK=
SW13 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfTc|F5UUN3ME2wMlE3OjF4IN88US=> MkjUV2FPT0WU
BB30-HNC M1q0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD2NZZGUUN3ME2wMlE3PTd4IN88US=> MkPDV2FPT0WU
HSC-2 NUD2fYwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHiXolKSzVyPUCuNVY5OzdizszN M1;xeXNCVkeHUh?=
BV-173 NXy2T2JqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi3THVKSzVyPUCuNVc2QTZizszN M2W2SHNCVkeHUh?=
CAL-27 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPWS4tKSzVyPUCuNVc3OzZizszN NGPzdJhUSU6JRWK=
SBC-1 NGK2dI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMUi5OVkh|ryP NGDpSZRUSU6JRWK=
CAL-33 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMkCxPFQh|ryP M3nidXNCVkeHUh?=
NCI-H209 NV7XSIEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTqUlBqUUN3ME2wMlIxPDZizszN MXjTRW5ITVJ?
COR-L105 NX\iV2JYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPTTWM2OD1yLkKxNFg1KM7:TR?= MXXTRW5ITVJ?
HSC-3 NV75TWNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMkGxPVgh|ryP Mm\pV2FPT0WU
NCI-H69 MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXi5PHR5UUN3ME2wMlIyPDVzIN88US=> NH7ofmNUSU6JRWK=
MOLT-13 M3[4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\VXXJKSzVyPUCuNlM6PzVizszN NVvERWVsW0GQR1XS
ML-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMkS4NFIh|ryP MU\TRW5ITVJ?
IGROV-1 M321W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMkW5OVIh|ryP MoPyV2FPT0WU
TK10 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXNWVZKSzVyPUCuNlY4OzhizszN M3n1OnNCVkeHUh?=
EoL-1-cell NF:1[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMk[4PVIh|ryP NHT2dGdUSU6JRWK=
HO-1-N-1 M4fDOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Tvd2lEPTB;MD6yO|g2OyEQvF2= M17EbXNCVkeHUh?=
BHY MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjndog2UUN3ME2wMlI5PjV3IN88US=> NF\ndpNUSU6JRWK=
LU-139 MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vHNmlEPTB;MD6zNFUyKM7:TR?= MWHTRW5ITVJ?
23132-87 M4XKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\pTWM2OD1yLkOxPVI{KM7:TR?= MnOzV2FPT0WU
ACHN Mkf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\ROVVKSzVyPUCuN|E6QTRizszN NHfPOHRUSU6JRWK=
DoTc2-4510 NH60dYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnf0TWM2OD1yLkOyNlE6KM7:TR?= NFjCfXFUSU6JRWK=
BB65-RCC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTPVVVxUUN3ME2wMlM1PTl|IN88US=> NWrQdWhzW0GQR1XS
HLE NF23cohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXRZ41KSzVyPUCuN|UxPDZizszN MVfTRW5ITVJ?
HCC1419 NGTx[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD0TWM2OD1yLkO2OFA5KM7:TR?= NUniN3ZnW0GQR1XS
A388 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nTT2lEPTB;MD6zOlg2PyEQvF2= MUDTRW5ITVJ?
NUGC-3 NHTJeFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwM{izO|Mh|ryP NWLW[VlEW0GQR1XS
KYSE-180 NG\YWnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;QbXhKSzVyPUCuN|kxQDlizszN NFrYUHFUSU6JRWK=
TE-6 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\Kd2lEPTB;MD60NFI1PiEQvF2= NFnJdVJUSU6JRWK=
A498 NILWZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1K0OmlEPTB;MD60NFY4PCEQvF2= MkDGV2FPT0WU
NCI-H1648 MoG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D2bmlEPTB;MD60OFE5OiEQvF2= Mmm1V2FPT0WU
DU-145 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTJOYluUUN3ME2wMlQ1QDN|IN88US=> MV\TRW5ITVJ?
CW-2 NELaVolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\3PIttUUN3ME2wMlQ3QTF2IN88US=> MkC1V2FPT0WU
A431 Mn23S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwNEiyN|Mh|ryP NWnRfYZZW0GQR1XS
SAS MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwNEizPVgh|ryP NYLwZ5g{W0GQR1XS
NCI-H2126 M{TnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDoTWM2OD1yLkWxPVI3KM7:TR?= MVjTRW5ITVJ?
NCI-H358 MnLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXj3TIlWUUN3ME2wMlU{OjFizszN NGPDeoxUSU6JRWK=
FADU NWHJUmJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDSNpRKSzVyPUCuOVQ1ODRizszN MlPGV2FPT0WU
ACN NYfjdFFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTNe5RUUUN3ME2wMlU2ODl2IN88US=> NH3sN4VUSU6JRWK=
HCC70 NIf2OmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PmZWlEPTB;MD61O|Y3OSEQvF2= MlrIV2FPT0WU
NCI-H1838 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NViyXHQ5UUN3ME2wMlYxOjl7IN88US=> NHnZRZhUSU6JRWK=
CAL-54 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjwZ2plUUN3ME2wMlYyPjJzIN88US=> MXTTRW5ITVJ?
NCI-H1975 NXnjfXp7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFj6ZWRKSzVyPUCuOlE4OjhizszN NE\GdHhUSU6JRWK=
COR-L88 NYfoU3U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHuTXFKSzVyPUCuOlQyOTNizszN NHPnZnFUSU6JRWK=
CTV-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwNkSzPVIh|ryP NYrudZh2W0GQR1XS
EW-18 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwNki2PVgh|ryP NXXYclk1W0GQR1XS
HCC1806 M2n1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P4eGlEPTB;MD62PVY3PiEQvF2= NX7lNFF2W0GQR1XS
HuP-T4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K1VGlEPTB;MD62PVc3KM7:TR?= M2L3SHNCVkeHUh?=
MDA-MB-361 NFrIO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwN{K2OlIh|ryP MYHTRW5ITVJ?
NCI-H1573 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M32zS2lEPTB;MD63N|Y{KM7:TR?= NWW3dmJkW0GQR1XS
KU-19-19 MlvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvaV3JqUUN3ME2wMlc4PDZ2IN88US=> NFvrNmJUSU6JRWK=
COLO-678 Mo\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjxNYZKSzVyPUCuPFA5OzRizszN NYf2bowxW0GQR1XS
C-33-A NIKwR2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPNTVJ5UUN3ME2wMlgyOjl5IN88US=> MnXJV2FPT0WU
Calu-3 NHnuUWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7PfJFKSzVyPUCuPFE1OzRizszN M4Xv[nNCVkeHUh?=
AGS M1HpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjwPWpKSzVyPUCuPFM3PDhizszN MVvTRW5ITVJ?
SCC-25 MnPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwOESxO|Eh|ryP NUDzT3Z3W0GQR1XS
JVM-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwOEiyPVkh|ryP NYPyflRNW0GQR1XS
HCE-T NXnFNGFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmizTWM2OD1yLki4OFI5KM7:TR?= NU\nc5RjW0GQR1XS
ES4 M1PKc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PpVWlEPTB;MD65O|g{PiEQvF2= NWHxNIRnW0GQR1XS
EKVX M1ztWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFwMEGwOlQh|ryP NYXaN25CW0GQR1XS
D-542MG NF3ZN2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHf0VJNKSzVyPUGuNFExPjRizszN NWrO[HpkW0GQR1XS
SW1116 NXfCT2xwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHtfodKSzVyPUGuNFEzQDdizszN NFzBPJBUSU6JRWK=
5637 M{jVTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrQbGw5UUN3ME2xMlAyPTFizszN NI\IdZZUSU6JRWK=
HT-1376 NVntVVFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHKS3VKSzVyPUGuNFE2OTNizszN MkDpV2FPT0WU
NB69 MlrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XCOGlEPTB;MT6wNlk1PSEQvF2= NHnUdIdUSU6JRWK=
YKG-1 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj1bIpKSzVyPUGuNFU1OTlizszN MU\TRW5ITVJ?
EW-3 NYjBeItIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M361OmlEPTB;MT6wO|g5OyEQvF2= NFW2b29USU6JRWK=
GCIY MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHQUo1KSzVyPUGuNFgyODRizszN M17KOXNCVkeHUh?=
SK-MES-1 M33rR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vGcmlEPTB;MT6xNVQ5PyEQvF2= NYLJdVNTW0GQR1XS
PANC-08-13 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfPTWM2OD1zLkG2OFE3KM7:TR?= MV\TRW5ITVJ?
SK-NEP-1 NYX2[3RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zySGlEPTB;MT6xO|UyOyEQvF2= NV7oSZNuW0GQR1XS
SW954 NFjKd2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37m[mlEPTB;MT6yNFIyPCEQvF2= M3;FdHNCVkeHUh?=
NCI-SNU-5 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrmPFFOUUN3ME2xMlI{QSEQvF2= MoPqV2FPT0WU
SW48 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXTTWM2OD1zLkK1OFMzKM7:TR?= MVvTRW5ITVJ?
HT-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnl[mY4UUN3ME2xMlI5PzV|IN88US=> NXPvXnhWW0GQR1XS
ETK-1 M2e2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTFwM{e0OVYh|ryP NEj2cItUSU6JRWK=
SCC-15 M4LhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnpTWM2OD1zLkO5OFUyKM7:TR?= M3fFT3NCVkeHUh?=
DU-4475 NHzxRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUi3TlBqUUN3ME2xMlQxOTJzIN88US=> NI\IVHRUSU6JRWK=
NB5 M2fXSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonNTWM2OD1zLkSxN|E4KM7:TR?= NWnnV2J1W0GQR1XS
CFPAC-1 M4KyW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPxZ2lKSzVyPUGuOFI1QTNizszN NICxZ5BUSU6JRWK=
NCI-H630 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LRWmlEPTB;MT60OVU5OiEQvF2= MU\TRW5ITVJ?
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NCI-H1993 NVXxeW5OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnsV2dKSzVyPUiuN|M3OzFizszN NVfBbGZ3W0GQR1XS
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BFTC-909 NWnrc4k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Pn[2lEPTB;OT6wOlc6QSEQvF2= M17nVHNCVkeHUh?=
EW-11 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7sUWVIUUN3ME25MlE4PjV|IN88US=> MXXTRW5ITVJ?
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BALL-1 M320fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LWXmlEPTB;OT6yNVkxPyEQvF2= M3\ZWHNCVkeHUh?=
SF539 M3S1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D3e2lEPTB;OT6yN|U3OiEQvF2= MlHoV2FPT0WU
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C32 M1nO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfhVmtKSzVyPUmuN|MxPjRizszN MWnTRW5ITVJ?
NCI-H1703 MoLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPDOmZKSzVyPUmuN|Q{PzVizszN NXHtZlNCW0GQR1XS
NCI-H1650 NF7CNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7rdFBxUUN3ME25MlYxQTR4IN88US=> MlLJV2FPT0WU
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CAL-85-1 M1W2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrZdXJKSzVyPUmuPFc{QDNizszN NXO0NYdDW0GQR1XS
UM-UC-3 MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4W2XWlEPTB;OT65OVA{KM7:TR?= MULTRW5ITVJ?
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DEL NH3S[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWyeodHUUN3ME2xNE4{QTR4IN88US=> MoDlV2FPT0WU
HuCCT1 MkPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTFyLk[wN|Mh|ryP M3XoW3NCVkeHUh?=
OVCAR-4 M4\YZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX25ZodmUUN3ME2xNE45QDN3IN88US=> MXTTRW5ITVJ?
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HCC1954 M13ObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TJO2lEPTB;MUGuNFc2PCEQvF2= MlnQV2FPT0WU
EFO-21 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LLUmlEPTB;MUGuNVA1PSEQvF2= NVzDWVg4W0GQR1XS
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UACC-62 MnvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLISmhTUUN3ME2xNU4zOzZ6IN88US=> MmW2V2FPT0WU
NCI-H650 NVnMZYM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;0XmtsUUN3ME2xNU4zPDF6IN88US=> MmXEV2FPT0WU
ALL-PO NFXUeY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTFzLkK1NVIh|ryP NF3zbo5USU6JRWK=
T84 NXLsS|JMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFzLkO5NFch|ryP NFnIOnNUSU6JRWK=
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SW626 M4jw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3S4bmlEPTB;MUGuOVc2PSEQvF2= MmfqV2FPT0WU
RPMI-2650 NWDke3hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonkTWM2OD1zMT61PFg2KM7:TR?= M4f2SHNCVkeHUh?=
MC-IXC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUT5PYE3UUN3ME2xNU43PzJ6IN88US=> NHS4[3FUSU6JRWK=
HOP-62 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfiSXB1UUN3ME2xNU43PzZ2IN88US=> NFHoWIxUSU6JRWK=
NOS-1 MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXOWXZKSzVyPUGxMlcyODlizszN NXHsc3JiW0GQR1XS
SW1573 NXXa[Ws6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjEOZlKSzVyPUGxMlczQTVizszN MnzVV2FPT0WU
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HuO9 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnzZpdKSzVyPUGxMlg4PzRizszN NVjaXZFIW0GQR1XS
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MDA-MB-453 NHHZZWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTFzLkm1NVUh|ryP MYfTRW5ITVJ?
NCI-H596 M4nW[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[1NWlEPTB;MUKuNFM3QSEQvF2= M2qzTHNCVkeHUh?=
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SW837 NWHKPHVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Toc2lEPTB;MUKuPVAzQCEQvF2= M4LtenNCVkeHUh?=
NMC-G1 NV7aS3Z1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H6d2lEPTB;MUKuPVI{PCEQvF2= Mo[xV2FPT0WU
PFSK-1 M3\PZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTF|LkC2JO69VQ>? MoS4V2FPT0WU
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SK-UT-1 MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXW[40zUUN3ME2xN{4yODh|IN88US=> NHexdolUSU6JRWK=
OVCAR-5 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;6RWlEPTB;MUOuNVU6OyEQvF2= M3mybnNCVkeHUh?=
8505C M3\mc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHhdmpuUUN3ME2xN{4zODZ5IN88US=> NYHkeYlnW0GQR1XS
SK-MEL-1 MnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF|LkexN|Uh|ryP NVjRflZYW0GQR1XS
LK-2 NXPLVWdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTF|Lke2N|kh|ryP MofUV2FPT0WU
OE33 NWX1VJVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmj2TWM2OD1zMz63PFYh|ryP MULTRW5ITVJ?
Ramos-2G6-4C10 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vaXmlEPTB;MUSuNFIxOiEQvF2= M1LnV3NCVkeHUh?=
EW-13 M4\hcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m2dmlEPTB;MUSuNFM2OiEQvF2= NVnx[5ZOW0GQR1XS
NCI-H1793 NI\XV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPoU3RUUUN3ME2xOE4zODh5IN88US=> MVLTRW5ITVJ?
BHT-101 MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzzXYRSUUN3ME2xOE4zPDFizszN MWjTRW5ITVJ?
RKO MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K3OGlEPTB;MUSuOVA4PSEQvF2= NGLWbYlUSU6JRWK=
NEC8 MlnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn3TWM2OD1zND61OFczKM7:TR?= NWHQdlhZW0GQR1XS
PANC-10-05 MluxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF2Lk[yOFch|ryP MU\TRW5ITVJ?
NCI-H2030 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzwTWM2OD1zND62OFQ5KM7:TR?= NESxWZpUSU6JRWK=
C2BBe1 MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fIUmlEPTB;MUSuO|Y1KM7:TR?= NFTaZnZUSU6JRWK=
EM-2 M4ryU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XYN2lEPTB;MUSuPFU4PiEQvF2= NYrKW3I2W0GQR1XS
HCC1395 NEmyNmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fLPGlEPTB;MUSuPVM{QCEQvF2= MnvwV2FPT0WU
A2058 MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm3W4FKSzVyPUG1MlA1ODlizszN NXjZZYtiW0GQR1XS
SW1463 M4LuNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXSy[WNWUUN3ME2xOU4xPDh3IN88US=> M3PRZXNCVkeHUh?=
J82 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHZSlVKSzVyPUG1MlA2PyEQvF2= M2DHVXNCVkeHUh?=
CAL-120 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF3LkG0OFch|ryP NIj4bZVUSU6JRWK=
COLO-824 M{DiO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW3TWM2OD1zNT6xOVc6KM7:TR?= MYnTRW5ITVJ?
LNCaP-Clone-FGC M3yyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTF3LkSyOFgh|ryP MVrTRW5ITVJ?
CP66-MEL NHnXeWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3POcmlEPTB;MUWuOFY5QCEQvF2= M3rFNnNCVkeHUh?=
OC-314 NXHoVHVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Ln[2lEPTB;MUWuOFcyPCEQvF2= NIHPXoNUSU6JRWK=
OVCAR-8 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:0PGpYUUN3ME2xOU45QDZzIN88US=> MXTTRW5ITVJ?
MFE-280 M1vaUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq4V41VUUN3ME2xOk4xPDh6IN88US=> NIfUdZZUSU6JRWK=
MHH-NB-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTOTWM2OD1zNj6wPFM6KM7:TR?= MV7TRW5ITVJ?
SW1990 M4fTXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPrSFczUUN3ME2xOk4yPzV3IN88US=> MUPTRW5ITVJ?
U-266 MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTF4LkKyPVkh|ryP M4XrWXNCVkeHUh?=
MFM-223 NV3xS|BHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfrTWM2OD1zNj6zPVY2KM7:TR?= M4LOTXNCVkeHUh?=
L-363 MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPVPXZrUUN3ME2xOk41PTd5IN88US=> M{O1bHNCVkeHUh?=
MCF7 Ml\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vQSmlEPTB;MU[uOFczOyEQvF2= M33seHNCVkeHUh?=
SK-MEL-3 NWL4emNWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDxTWM2OD1zNj60O|g4KM7:TR?= MX3TRW5ITVJ?
HH M4[yOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTyd|VKSzVyPUG2MlUyPjJizszN NF;nfmZUSU6JRWK=
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HuP-T3 NVX3T2hbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\6ZlR5UUN3ME2xOk43PTd4IN88US=> MkGzV2FPT0WU
QIMR-WIL MnHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrFU5ZbUUN3ME2xOk44OTB3IN88US=> NWfnPG9XW0GQR1XS
NCI-H1092 M4T1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXLdHlKSzVyPUG2Mlg{OTZizszN NX7Oc3o1W0GQR1XS
MZ2-MEL NETBOHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nqNWlEPTB;MU[uPFQxOyEQvF2= NE\BdYpUSU6JRWK=
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COLO-684 Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF4Lkm0O|ch|ryP MUjTRW5ITVJ?
NCI-H661 NFvqb45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjYeGs4UUN3ME2xOk46Pjl2IN88US=> MWjTRW5ITVJ?
CP50-MEL-B NYHBdHhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIi5ZlZKSzVyPUG3MlA{PDNizszN M2\ERXNCVkeHUh?=
NCI-H2405 MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLDWoJTUUN3ME2xO{4yQTd2IN88US=> NEDFRVlUSU6JRWK=
U-2-OS Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTF5LkWzNFch|ryP MlvkV2FPT0WU
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NCI-H2342 NFLRTFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\VTWM2OD1zNz61OVch|ryP M3iwOnNCVkeHUh?=
ES8 M{LPUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{W0[GlEPTB;MUeuOlA5PyEQvF2= MWjTRW5ITVJ?
MOLT-16 M{jhT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonJTWM2OD1zNz64PVM1KM7:TR?= MkHnV2FPT0WU
RH-18 NFf5ZYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDpTWM2OD1zOD6wNFM2KM7:TR?= M2LYXXNCVkeHUh?=
D-283MED NVruNZdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjHTnl2UUN3ME2xPE4xODh6IN88US=> NIjxXmNUSU6JRWK=
RCC10RGB MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrDcodKSzVyPUG4MlA2PTlizszN Ml3UV2FPT0WU
NCI-H1437 NHiwXppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL4TWM2OD1zOD6xOlQyKM7:TR?= NY\2cmYxW0GQR1XS
SW982 NHL6UpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTF6LkK2O|Eh|ryP NIL6TVNUSU6JRWK=
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A704 NIDoPGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTCTWM2OD1zOD60O|U{KM7:TR?= MoHSV2FPT0WU
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SCH M1PMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq4OmdKSzVyPUG4MlY1PTZizszN Mn;yV2FPT0WU
COLO-320-HSR M1nCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXhVldKUUN3ME2xPE44PDZizszN M{\iTXNCVkeHUh?=
Mo-T MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmG4TWM2OD1zOD64NlA1KM7:TR?= MYHTRW5ITVJ?
Saos-2 MlWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkmwTWM2OD1zOT6xNVYzKM7:TR?= NXPvWJVPW0GQR1XS
SW684 NXPwZnVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ezPGlEPTB;MUmuNVMzPiEQvF2= NXe3Z2p[W0GQR1XS
KMOE-2 M13pNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\NR4xDUUN3ME2xPU4zOjR{IN88US=> NUX2So15W0GQR1XS
MMAC-SF MlrZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1z3b2lEPTB;MUmuNlYxPyEQvF2= NXfLNoE2W0GQR1XS
JAR MlvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF7LkK5PUDPxE1? MkjSV2FPT0WU
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MZ7-mel NULzeGo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCwTWM2OD1|ND62OFg4KM7:TR?= NYCzcWtuW0GQR1XS
NCI-H810 M{CzU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnWTWM2OD1|ND63Nlc5KM7:TR?= MULTRW5ITVJ?
D-392MG MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jrPGlEPTB;M{WuNFU3PSEQvF2= M3K0bXNCVkeHUh?=
LB771-HNC NE\Xd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\UR4dUUUN3ME2zOU4yPjV6IN88US=> NGXibW1USU6JRWK=
COLO-679 M1LRfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvERWFKSzVyPUO1MlM5QCEQvF2= MmfXV2FPT0WU
SK-PN-DW M{ixSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTN3LkSzOlkh|ryP NXnrTG5oW0GQR1XS
VA-ES-BJ NWe0W5ZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTN3LkS2OFkh|ryP NYS1cWF1W0GQR1XS
KNS-42 NWK3UFFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;ETWM2OD1|NT61PFI3KM7:TR?= NEDqWIpUSU6JRWK=
RVH-421 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWiwfmUxUUN3ME2zOU44PjR3IN88US=> NEjyW29USU6JRWK=
P30-OHK NVvKXZFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTN3Lki3OVIh|ryP MXvTRW5ITVJ?
G-402 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlGyTWM2OD1|NT65PFY4KM7:TR?= MVTTRW5ITVJ?
S-117 NXnsPVBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTDTWM2OD1|Nj6zNFA5KM7:TR?= MlnNV2FPT0WU
RXF393 NHXscVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTN4LkO3PFUh|ryP NXTjWWt1W0GQR1XS
LCLC-103H M{TaZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13TSGlEPTB;M{[uO|gxOyEQvF2= NXy5SJlRW0GQR1XS
U-118-MG NGDGUZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTN4Lki4OFch|ryP NV7mR5RRW0GQR1XS
8-MG-BA NYfDbZVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vtc2lEPTB;M{[uPVQ5OyEQvF2= NHTzVmNUSU6JRWK=
MFH-ino NIDuNlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\hcpo5UUN3ME2zO{4{OzdzIN88US=> MWHTRW5ITVJ?
NCI-H23 MlrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrXW4tKSzVyPUO3MlQyQTZizszN M3W1OXNCVkeHUh?=
NCI-H446 M2qzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[5TWM2OD1|Nz60PFYzKM7:TR?= MXXTRW5ITVJ?
LU-99A MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIOzeFhKSzVyPUO3MlU4OzFizszN MkH6V2FPT0WU
KP-N-YN MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPkb|dKSzVyPUO3MlYyQTVizszN MoTxV2FPT0WU
SCC-9 NUWwdlBVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLPXHBTUUN3ME2zO{44QDN6IN88US=> NFy1Nm9USU6JRWK=
EFM-19 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3NdYhKSzVyPUO3Mlc6PjdizszN Mlv4V2FPT0WU
A427 MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mki4TWM2OD1|Nz65NVA4KM7:TR?= MU\TRW5ITVJ?
LB831-BLC NVvy[IlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\6XmlEPTB;M{iuOlA{QSEQvF2= NWfOVINZW0GQR1XS
HOS M1PQc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TtPGlEPTB;M{muOlI4OyEQvF2= NYfOTFR[W0GQR1XS
LAN-6 MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTRyLkCxNVIh|ryP MWnTRW5ITVJ?
U251 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrmZmZnUUN3ME20NE41ODV2IN88US=> NVzqXGtMW0GQR1XS
SNU-387 M{jIVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\EW5h3UUN3ME20NE41PTV|IN88US=> NILiXHFUSU6JRWK=
DMS-79 NED6bndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTRyLkW4PFkh|ryP NXGzXmR3W0GQR1XS
SK-LU-1 NYrodVdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln1TWM2OD12MD62OVY5KM7:TR?= MmPRV2FPT0WU
HT MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTRyLk[2N|kh|ryP NFLGS21USU6JRWK=
KP-N-YS M4jKdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPpTWM2OD12MD62O|Y5KM7:TR?= MmC5V2FPT0WU
DMS-114 MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHHTmNKSzVyPUSwMlg{PzRizszN NULwTIZNW0GQR1XS
HUTU-80 MmnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr6WlBQUUN3ME20NU4xPTZ7IN88US=> NWWyRnlxW0GQR1XS
ONS-76 NXrFOJFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTRzLkS3NFkh|ryP MkPXV2FPT0WU
A673 NUjvOXp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLhTWM2OD12MT61NVU4KM7:TR?= MV3TRW5ITVJ?
HPAF-II NYK0U2dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\aVG13UUN3ME20NU43PzB7IN88US=> NGS0SYpUSU6JRWK=
UACC-257 M4C1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:3[WlEPTB;NEGuO|M3QSEQvF2= MVPTRW5ITVJ?
EW-22 NXnKRoFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfL[FRKSzVyPUSxMlg3QTdizszN M2DiUHNCVkeHUh?=
NCI-H1755 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTRzLki3NlUh|ryP M2DMXHNCVkeHUh?=
KYSE-150 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHNdmFKSzVyPUSyMlE4QDJizszN M{\DVnNCVkeHUh?=
CGTH-W-1 NF;JSoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfteXhKSzVyPUSyMlQ6PTVizszN M1XVWnNCVkeHUh?=
NB13 M1\T[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\XTWM2OD12Mj62NlE4KM7:TR?= NVexWFhZW0GQR1XS
SW872 NUfONINNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LJSWlEPTB;NEKuOlM{OSEQvF2= NF\V[ItUSU6JRWK=
KP-4 Mmm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDkTWM2OD12Mj64PFMzKM7:TR?= NVzZbJNHW0GQR1XS
HCC38 NWq5bZR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTDV3RKSzVyPUSyMlk3OThizszN NXrWWFFsW0GQR1XS
BB49-HNC MlvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P2RmlEPTB;NEOuNlM2PiEQvF2= NF;qbHVUSU6JRWK=
CAL-62 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7GeYJKSzVyPUSzMlQxOjhizszN M13WW3NCVkeHUh?=
NCI-H2029 MkPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTR|LkW1PFEh|ryP NETvcWtUSU6JRWK=
M14 NILFd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\IcFRKSzVyPUS0MlE{OzJizszN M3LJb3NCVkeHUh?=
COLO-680N NFzL[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTR2LkOzPUDPxE1? M2\UNXNCVkeHUh?=
Hs-578-T NWnm[GJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLXTWM2OD12NT6wNlk1KM7:TR?= MYHTRW5ITVJ?
MSTO-211H NU\q[|B4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\L[GlEPTB;NEWuPVQ5OiEQvF2= MkezV2FPT0WU
EW-1 NVTOSWNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nQV2lEPTB;NEWuPVY5QSEQvF2= NXS3UGNkW0GQR1XS
SW948 NHO2b2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H0VGlEPTB;NE[uOFQ3OiEQvF2= M3G2enNCVkeHUh?=
NCI-H460 Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vYZmlEPTB;NE[uOVI{KM7:TR?= NXXERoF3W0GQR1XS
CAS-1 NVPKSogyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTR4Lke3NFEh|ryP NWnySlJsW0GQR1XS
TGBC11TKB MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M134eGlEPTB;NEeuNVc4PyEQvF2= NUTXSY5PW0GQR1XS
HD-MY-Z NYj2XlBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDlcG1KSzVyPUS4Mlc5PiEQvF2= MV\TRW5ITVJ?
NCI-H226 NWXTU5R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvDOZNKSzVyPUS5Mlc4QDVizszN NUflcFFCW0GQR1XS
PA-1 NIj0W5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfpTWM2OD12OT64N|M2KM7:TR?= NV7WeXhXW0GQR1XS
LB2518-MEL MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfnOoJtUUN3ME20PU45PzJ|IN88US=> NIjDdVZUSU6JRWK=
A101D MoLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXGSXdKSzVyPUS5Mlk1OjVizszN MULTRW5ITVJ?
NCI-H2087 M2nKZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILxSHhKSzVyPUS5Mlk3QDJizszN NIPJd4RUSU6JRWK=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

p-VEGFR2 / VEGFR2 / JAG1 / DLL4 / NICD1 ; 

PubMed: 28533486     


HUVECs were cultured in the presence of Vatalanib (100 nM) or DBZ (10 nM) for 1 h and then treated for 15 min with rhgal-3 (37 nM) and cultured for additional 6 hrs. After this period, the total protein was isolated and the protein levels of galectin-3, NICD1, DLL4, JAG1, VEGFR2 and VEGFR2-p were assessed by Western blot. β-actin was used as a loading control.

25537503 26052929 28533486
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03711422 Not yet recruiting Drug: Afatinib Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03083678 Recruiting Drug: Afatinib Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2
NCT03370770 Active not recruiting Drug: Afatinib|Drug: Osimertinib Carcinoma Non-Small-Cell Lung Boehringer Ingelheim December 28 2017 --
NCT02423525 Recruiting Drug: Afatinib Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute December 2016 Phase 1
NCT02695290 Terminated Drug: Afatinib Carcinoma Non-Small-Cell Lung|ErbB Receptors Boehringer Ingelheim March 17 2016 Phase 4
NCT02171741 Completed Drug: BIBW 2992|Drug: Docetaxel Neoplasms Boehringer Ingelheim April 2005 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID