Afatinib (BIBW2992)

Catalog No.S1011

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 570 In stock
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Cited by 37 Publications

4 Customer Reviews

  • Cytoxicity of irreversible EGFR TKIS and ethacrynic acid on breast cells lines. A, Mean IC50 value of Afatinib.

    Oncotarget, 2016, 7(36):58038-58050. Afatinib (BIBW2992) purchased from Selleck.

    Inhibition of signaling pathway activation in lung tumor cell lines by kinase inhibitors. Lung tumor cells were cultured in 10% FBS until reaching ∼80% confluence and then the cells were starved in serum-free medium for overnight, followed by 4-hour treatment with the inhibitors. Cell lysates were then prepared and used for determination of the pathway activation signals by the CEER assay.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

  • Inhibition of anchorage-independent growth of lung tumor cell lines by selected inhibitors. Each selected cell line was treated with the indicated inhibitor at 0.1 μM and 1 μM concentrations for two weeks and cell colony size formation was scored under the Nikon inverted-phase microscope.

    Int J Proteomics 2011 2011, 215496. Afatinib (BIBW2992) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of BIBW2992 for 3h,followed by 15-minute stimolation of 100ng/ml EGF

    Dr. Zhang of Tianjin Medical University. Afatinib (BIBW2992) purchased from Selleck.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M{LjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIP3VWlKSzVyPUCuNFA2PzJizszN NY\WUY5DW0GQR1XS
KASUMI-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV[2XppQUUN3ME2wMlAxQTFzIN88US=> NI[4NnNUSU6JRWK=
HCC2218 Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrXVYZKSzVyPUCuNFA6QDdizszN MYLTRW5ITVJ?
KARPAS-45 NVu5b29YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PaS2lEPTB;MD6wNVY4OSEQvF2= Mm\0V2FPT0WU
HSC-4 M3jFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXDcmZKSzVyPUCuNFE4PDhizszN MV;TRW5ITVJ?
CHL-1 NIraephIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTpbI5DUUN3ME2wMlAyQDN7IN88US=> M4DXTnNCVkeHUh?=
KY821 M2jZOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jodmlEPTB;MD6wNlA3KM7:TR?= NXjTdYxNW0GQR1XS
NCI-N87 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoqyTWM2OD1yLkCyO|c{KM7:TR?= M{\EfHNCVkeHUh?=
DOK NHnROVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4exbWlEPTB;MD6wN|E6PCEQvF2= M2XVNnNCVkeHUh?=
DSH1 Mkm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnEVo5qUUN3ME2wMlA{OzF2IN88US=> NGnoe2lUSU6JRWK=
MDA-MB-175-VII MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LHeGlEPTB;MD6wN|QyPiEQvF2= NXS5eYttW0GQR1XS
NCI-H2170 NFrk[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwMEO3Nlgh|ryP MWHTRW5ITVJ?
BT-474 NYG1TZdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMES5PFYh|ryP NEK2RlFUSU6JRWK=
EFO-27 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMEWxPFIh|ryP M2fmOnNCVkeHUh?=
NCI-H720 NF61T5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEWzNlUh|ryP MYLTRW5ITVJ?
PC-14 NHn1TJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHuTWM2OD1yLkC1OlY5KM7:TR?= M3nReXNCVkeHUh?=
EC-GI-10 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i3[mlEPTB;MD6wOVkyOiEQvF2= NYXCSVFzW0GQR1XS
KYSE-450 M{LFcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\aPGR5UUN3ME2wMlA2QTd6IN88US=> MnG3V2FPT0WU
BPH-1 NWTtWodHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHaZY12UUN3ME2wMlA2QTh6IN88US=> NFnucZJUSU6JRWK=
NCI-H292 NVH3[5hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPTNnJKSzVyPUCuNFYxQSEQvF2= MonPV2FPT0WU
H9 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC5SWJKSzVyPUCuNFcyOzJizszN NEOzOWZUSU6JRWK=
NCI-H526 NXv6cXVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPYSGFLUUN3ME2wMlA4QDJ|IN88US=> NXnuXoFbW0GQR1XS
NCI-H1623 NHL5cmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrmU|hKSzVyPUCuNFgxOjVizszN MnixV2FPT0WU
KYSE-140 NWLOOmZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPYXolKSzVyPUCuNFg{OyEQvF2= MnX0V2FPT0WU
Ca9-22 NVHGeVVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvZTWM2OD1yLkC4N|U{KM7:TR?= MY\TRW5ITVJ?
AU565 MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMEi1NFQh|ryP M4j6O3NCVkeHUh?=
ZR-75-30 M1fCZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEm1OFUh|ryP NVPxTZlkW0GQR1XS
NCI-H1770 MmLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\iO455UUN3ME2wMlExOjhizszN NUTCXlJkW0GQR1XS
LB2241-RCC MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWe3OZUzUUN3ME2wMlExQDh2IN88US=> M{HtU3NCVkeHUh?=
CAL-39 Mn3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMUG3PVIh|ryP NWWzd3IxW0GQR1XS
UACC-893 Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi3bVcxUUN3ME2wMlEyQDh3IN88US=> Ml7CV2FPT0WU
LU-65 NVX6OVBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPhTWM2OD1yLkGyOlM{KM7:TR?= M1mxOnNCVkeHUh?=
HN MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDqTWM2OD1yLkGzNFc4KM7:TR?= NHXxXmFUSU6JRWK=
TI-73 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXETFBKSzVyPUCuNVQ4OTVizszN MUnTRW5ITVJ?
KU812 NFvQNpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDo[mtSUUN3ME2wMlE2PDV4IN88US=> NUHaWGw5W0GQR1XS
SW13 MmDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXKPXk4UUN3ME2wMlE3OjF4IN88US=> M4PkTXNCVkeHUh?=
BB30-HNC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrPTWM2OD1yLkG2OVc3KM7:TR?= MXLTRW5ITVJ?
HSC-2 M2fCOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPuO5dKSzVyPUCuNVY5OzdizszN MnvrV2FPT0WU
BV-173 NXzo[IU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;3R|FWUUN3ME2wMlE4PTl4IN88US=> M3PWS3NCVkeHUh?=
CAL-27 NHXlTJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr1NXBEUUN3ME2wMlE4PjN4IN88US=> M4L6dXNCVkeHUh?=
SBC-1 M{T0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf5[WpKSzVyPUCuNVg6PTlizszN M{HZT3NCVkeHUh?=
CAL-33 M4XucGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L5[GlEPTB;MD6yNFE5PCEQvF2= MWPTRW5ITVJ?
NCI-H209 NV\ZOWVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXqyV|BQUUN3ME2wMlIxPDZizszN M2DYNnNCVkeHUh?=
COR-L105 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj0O5RKSzVyPUCuNlExQDRizszN NXTjUIVTW0GQR1XS
HSC-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTNTWM2OD1yLkKxNVk5KM7:TR?= NEnLdXdUSU6JRWK=
NCI-H69 NYnFTZhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHH3XZNKSzVyPUCuNlE1PTFizszN M2TyVXNCVkeHUh?=
MOLT-13 NVrXbIJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnpTWM2OD1yLkKzPVc2KM7:TR?= NWrkXndCW0GQR1XS
ML-2 M{XiPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXOTWM2OD1yLkK0PFAzKM7:TR?= NILkN25USU6JRWK=
IGROV-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TsTGlEPTB;MD6yOVk2OiEQvF2= NUnDVmU{W0GQR1XS
TK10 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTMN2lCUUN3ME2wMlI3PzN6IN88US=> MmHZV2FPT0WU
EoL-1-cell M2r6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV34PIVGUUN3ME2wMlI3QDl{IN88US=> M3PSTHNCVkeHUh?=
HO-1-N-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXnWGVKSzVyPUCuNlc5PTNizszN M33Ie3NCVkeHUh?=
BHY NI\IfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTyTWM2OD1yLkK4OlU2KM7:TR?= MnrTV2FPT0WU
LU-139 NVPPXZNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWeyTnNiUUN3ME2wMlMxPTFizszN NYLGOWlTW0GQR1XS
23132-87 M37xOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\4SXV[UUN3ME2wMlMyQTJ|IN88US=> MmrJV2FPT0WU
ACHN Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjBZ|hjUUN3ME2wMlMyQTl2IN88US=> NF3FXZFUSU6JRWK=
DoTc2-4510 NVjPSWk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfyTII3UUN3ME2wMlMzOjF7IN88US=> MWfTRW5ITVJ?
BB65-RCC NInyOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwM{S1PVMh|ryP NFvXUoxUSU6JRWK=
HLE Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTqTWM2OD1yLkO1NFQ3KM7:TR?= NEfSV3RUSU6JRWK=
HCC1419 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLRSHVJUUN3ME2wMlM3PDB6IN88US=> MUTTRW5ITVJ?
A388 NIG1c3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYO4c3p2UUN3ME2wMlM3QDV5IN88US=> M3XJb3NCVkeHUh?=
NUGC-3 M1y2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOxb2llUUN3ME2wMlM5Ozd|IN88US=> NGPtVmpUSU6JRWK=
KYSE-180 MmfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfBS4xKSzVyPUCuN|kxQDlizszN NVzodJNtW0GQR1XS
TE-6 NHHneZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\FOmlEPTB;MD60NFI1PiEQvF2= M4TocHNCVkeHUh?=
A498 NYLFfY5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjRfYlKSzVyPUCuOFA3PzRizszN NYXWO|ExW0GQR1XS
NCI-H1648 NELOc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDxXIN5UUN3ME2wMlQ1OTh{IN88US=> M2nLRnNCVkeHUh?=
DU-145 MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDSd3pKSzVyPUCuOFQ5OzNizszN M3zSbnNCVkeHUh?=
CW-2 M1LIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfzTWM2OD1yLkS2PVE1KM7:TR?= MXXTRW5ITVJ?
A431 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPaZ29KSzVyPUCuOFgzOzNizszN NXnGT5FIW0GQR1XS
SAS NWjKXWZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwNEizPVgh|ryP M{Lu[XNCVkeHUh?=
NCI-H2126 NHTKc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33YcWlEPTB;MD61NVkzPiEQvF2= NVnQepdrW0GQR1XS
NCI-H358 MnzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwNUOyNUDPxE1? NITFXHNUSU6JRWK=
FADU M{DJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHpNJprUUN3ME2wMlU1PDB2IN88US=> MW\TRW5ITVJ?
ACN M{HMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH75eJJKSzVyPUCuOVUxQTRizszN MmjiV2FPT0WU
HCC70 M{jC[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwNUe2OlEh|ryP M{[0RnNCVkeHUh?=
NCI-H1838 NVHmNpJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmToTWM2OD1yLk[wNlk6KM7:TR?= Mkf0V2FPT0WU
CAL-54 Mom2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwNkG2NlEh|ryP MVTTRW5ITVJ?
NCI-H1975 NHT2[IVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MornTWM2OD1yLk[xO|I5KM7:TR?= NUTCTIhTW0GQR1XS
COR-L88 NV:3fFBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHQS2VKSzVyPUCuOlQyOTNizszN NFnrZYhUSU6JRWK=
CTV-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknJTWM2OD1yLk[0N|kzKM7:TR?= M2X3enNCVkeHUh?=
EW-18 M{PjXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfZZ3dEUUN3ME2wMlY5Pjl6IN88US=> NETEWJpUSU6JRWK=
HCC1806 NYjEUZJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPBN4ZQUUN3ME2wMlY6PjZ4IN88US=> NYLXb4pxW0GQR1XS
HuP-T4 MlvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwNkm3OkDPxE1? NYTDNVVxW0GQR1XS
MDA-MB-361 NGTjfZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwN{K2OlIh|ryP M1HkXXNCVkeHUh?=
NCI-H1573 NGnkXYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jzVWlEPTB;MD63N|Y{KM7:TR?= MmfRV2FPT0WU
KU-19-19 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHCTWM2OD1yLke3OFY1KM7:TR?= NF7Ne4xUSU6JRWK=
COLO-678 NIDzUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrVNmVJUUN3ME2wMlgxQDN2IN88US=> MonNV2FPT0WU
C-33-A MoTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnj1TWM2OD1yLkixNlk4KM7:TR?= MoLtV2FPT0WU
Calu-3 M1i2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljJTWM2OD1yLkixOFM1KM7:TR?= MX;TRW5ITVJ?
AGS NHnz[ZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fXNmlEPTB;MD64N|Y1QCEQvF2= M2XOOHNCVkeHUh?=
SCC-25 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXHTWM2OD1yLki0NVcyKM7:TR?= M2LaXHNCVkeHUh?=
JVM-2 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X3VmlEPTB;MD64PFI6QSEQvF2= NHi5dWpUSU6JRWK=
HCE-T NGDQUnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\wV4hOUUN3ME2wMlg5PDJ6IN88US=> M1nzPXNCVkeHUh?=
ES4 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP6TWM2OD1yLkm3PFM3KM7:TR?= M3ft[nNCVkeHUh?=
EKVX NUH3bHlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3Re5RKSzVyPUGuNFExPjRizszN NU\hRldmW0GQR1XS
D-542MG NIXMcYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTFwMEGwOlQh|ryP NUftTFZRW0GQR1XS
SW1116 NY\j[FloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXS4N25vUUN3ME2xMlAyOjh5IN88US=> MnvwV2FPT0WU
5637 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XLO2lEPTB;MT6wNVUyKM7:TR?= MX\TRW5ITVJ?
HT-1376 NVT2R|lNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\WTGdqUUN3ME2xMlAyPTF|IN88US=> MU\TRW5ITVJ?
NB69 NHHqZXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlroTWM2OD1zLkCyPVQ2KM7:TR?= NHPGTWdUSU6JRWK=
YKG-1 NYjNb4NrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33OdWlEPTB;MT6wOVQyQSEQvF2= NXm4OXpTW0GQR1XS
EW-3 M4Lz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH2TWM2OD1zLkC3PFg{KM7:TR?= MlrnV2FPT0WU
GCIY MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j3cmlEPTB;MT6wPFExPCEQvF2= NWT6PFJGW0GQR1XS
SK-MES-1 M{DzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XNdGlEPTB;MT6xNVQ5PyEQvF2= Mn\jV2FPT0WU
PANC-08-13 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInmUVRKSzVyPUGuNVY1OTZizszN NEHVUY9USU6JRWK=
SK-NEP-1 MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nXOWlEPTB;MT6xO|UyOyEQvF2= M4S1WXNCVkeHUh?=
SW954 NVHBb5A1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHU[WJrUUN3ME2xMlIxOjF2IN88US=> NGfBWVVUSU6JRWK=
NCI-SNU-5 M2jX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHX3ZoJKSzVyPUGuNlM6KM7:TR?= NEnKTXJUSU6JRWK=
SW48 MlvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TmdGlEPTB;MT6yOVQ{OiEQvF2= Mnv5V2FPT0WU
HT-3 Mo\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTFwMki3OVMh|ryP NV73eXFIW0GQR1XS
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D-423MG M1y4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2qwPWlEPTB;NT62NVcxPSEQvF2= M3rS[3NCVkeHUh?=
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OAW-28 NHn4[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\5TWM2OD15Lkm0OVc5KM7:TR?= MXfTRW5ITVJ?
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CAL-72 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;pNoxCUUN3ME2xNE46OzlzIN88US=> MnmyV2FPT0WU
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SW626 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPsepdiUUN3ME2xNU42PzV3IN88US=> M{PMPHNCVkeHUh?=
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SW1573 M4DMV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnXTWM2OD1zMT63Nlk2KM7:TR?= NH7wbI1USU6JRWK=
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HuO9 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\wWFBFUUN3ME2xNU45Pzd2IN88US=> MVfTRW5ITVJ?
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NCI-H596 NITDSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xn[2lEPTB;MUKuNFM3QSEQvF2= MVzTRW5ITVJ?
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HCC1937 NIXUNJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnXTWM2OD1zMj63OVY1KM7:TR?= M3TyNnNCVkeHUh?=
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OVCAR-5 M2rkU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTF|LkG1PVMh|ryP NXXHOYhnW0GQR1XS
8505C MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnLZ3dJUUN3ME2xN{4zODZ5IN88US=> NHTmW3BUSU6JRWK=
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LK-2 NFG4NFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDB[oZXUUN3ME2xN{44PjN7IN88US=> M4DDVHNCVkeHUh?=
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NCI-H2030 NWL2fI1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;0eZNzUUN3ME2xOE43PDR6IN88US=> NELYZXVUSU6JRWK=
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HCC1395 M1fBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF2LkmzN|gh|ryP Mn\SV2FPT0WU
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COLO-824 M3nMSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTF3LkG1O|kh|ryP MXjTRW5ITVJ?
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CP66-MEL Mmj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTK[W83UUN3ME2xOU41Pjh6IN88US=> MUXTRW5ITVJ?
OC-314 NFu4N|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF3LkS3NVQh|ryP NILWTIhUSU6JRWK=
OVCAR-8 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDaTWM2OD1zNT64PFYyKM7:TR?= NGThTnFUSU6JRWK=
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U-266 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTF4LkKyPVkh|ryP MVHTRW5ITVJ?
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SK-MEL-3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTF4LkS3PFch|ryP M{ntPHNCVkeHUh?=
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NCI-H1092 MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT4bZI3UUN3ME2xOk45OzF4IN88US=> NIPBNYNUSU6JRWK=
MZ2-MEL Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWS4fJJZUUN3ME2xOk45PDB|IN88US=> MnS1V2FPT0WU
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COLO-684 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TiOmlEPTB;MU[uPVQ4PyEQvF2= M{\SPXNCVkeHUh?=
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CP50-MEL-B Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\DTWM2OD1zNz6wN|Q{KM7:TR?= MVXTRW5ITVJ?
NCI-H2405 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz3TWM2OD1zNz6xPVc1KM7:TR?= MYXTRW5ITVJ?
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NCI-H2342 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrnNY82UUN3ME2xO{42PTdizszN Mo\iV2FPT0WU
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MOLT-16 M{XaSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3LW|hQUUN3ME2xO{45QTN2IN88US=> MWPTRW5ITVJ?
RH-18 M{jPVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTF6LkCwN|Uh|ryP M{XGPHNCVkeHUh?=
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RCC10RGB NH3SRo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTkVFBtUUN3ME2xPE4xPTV7IN88US=> NUn1d5lSW0GQR1XS
NCI-H1437 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrRWlZKSzVyPUG4MlE3PDFizszN MnraV2FPT0WU
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SCH M2f0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTF6Lk[0OVYh|ryP NYX1[3h2W0GQR1XS
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Saos-2 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLJSFJ{UUN3ME2xPU4yOTZ{IN88US=> M4rnOXNCVkeHUh?=
SW684 NVvselM6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfvU|Z5UUN3ME2xPU4yOzJ4IN88US=> NWnhb45bW0GQR1XS
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JAR NH24fJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3n[GhZUUN3ME2xPU4zQTlizszN NVy3RlduW0GQR1XS
SK-MEL-28 M3\Ic2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF7LkOzOlMh|ryP MXvTRW5ITVJ?
KNS-81-FD M1H1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnDb|RKSzVyPUG5MlU1PjhizszN NIH3Z3ZUSU6JRWK=
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AsPC-1 NUnaXpNHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTrRWd2UUN3ME2xPU43PDdzIN88US=> M37CXXNCVkeHUh?=
NCI-H1155 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PvZmlEPTB;MUmuO|I{QCEQvF2= NYHHRYdUW0GQR1XS
KYSE-510 Ml\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPjR3hKSzVyPUG5Mlg4PDhizszN NVfIb49MW0GQR1XS
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PC-3 NV\tTJY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoqyTWM2OD1zOT65OlA1KM7:TR?= Mn;RV2FPT0WU
GCT NHzRRVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7DepdKSzVyPUKwMlMxOjZizszN MYLTRW5ITVJ?
KARPAS-299 M1fmcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TvW2lEPTB;MkCuN|QzOiEQvF2= NYPQSlN2W0GQR1XS
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COLO-741 NXrQNGRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJyLk[2JO69VQ>? NE[5NZFUSU6JRWK=
NCI-H1395 M2HLZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULzcG5KUUN3ME2yNE43Pjl5IN88US=> MU\TRW5ITVJ?
HCC1187 Mnr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLKTWM2OD1{MD62O|M1KM7:TR?= MnfRV2FPT0WU
Becker NF\YTpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHxSFJ3UUN3ME2yNE44OjBzIN88US=> M1LxWHNCVkeHUh?=
LU-134-A NE\lbpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXEbpY{UUN3ME2yNU4yODJ4IN88US=> Mm\BV2FPT0WU
MKN45 M3H0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f4fGlEPTB;MkGuNVU2OSEQvF2= NXfUXHhJW0GQR1XS
LC-2-ad MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDHfm9KSzVyPUKxMlI4OjlizszN M4rIR3NCVkeHUh?=
EW-24 NETwdHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJzLkO5OFUh|ryP NFLJTVJUSU6JRWK=
SK-N-AS M{CzZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fUbWlEPTB;MkGuPFI4PiEQvF2= MXTTRW5ITVJ?
NCI-H2052 M3:wbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW1V25KSzVyPUKxMlg6PjNizszN NVPpXm53W0GQR1XS
A4-Fuk NXG3dXZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTJ{LkG0NVkh|ryP M4rPN3NCVkeHUh?=
NB10 NFftbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vER2lEPTB;MkKuNlM4OSEQvF2= M2THSnNCVkeHUh?=
CHP-212 NX;XTGdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\4fFJ3UUN3ME2yNk4{OjJ{IN88US=> NF6wWFJUSU6JRWK=
KM12 MkD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP1TWM2OD1{Mj6zOVYh|ryP M4nBU3NCVkeHUh?=
JEG-3 NGPISZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrIeVJKSzVyPUKyMlM4QCEQvF2= NHq3NZRUSU6JRWK=
LN-405 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXRZopKSzVyPUKyMlU6OTNizszN MVnTRW5ITVJ?
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MLMA NVH0PYdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrGUIRKSzVyPUKyMlc1PyEQvF2= MV\TRW5ITVJ?
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RT-112 MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2m2NWlEPTB;MkKuPFYyPiEQvF2= M336PHNCVkeHUh?=
MPP-89 NYrVdHVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nWRWlEPTB;MkKuPFY3OSEQvF2= NWDYNFlnW0GQR1XS
A3-KAW NXq0SnB6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJ|LkGwNFMh|ryP NHyyRWZUSU6JRWK=
KALS-1 MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPNe|BKSzVyPUKzMlE1OTRizszN Mm\lV2FPT0WU
SF126 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPiTWM2OD1{Mz62PVI1KM7:TR?= NVrOdo5GW0GQR1XS
SiHa MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2G5VWlEPTB;MkOuPVMzPyEQvF2= NXjLb5JwW0GQR1XS
MDA-MB-415 M4n4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJ|Lkm0PVkh|ryP M1LhTHNCVkeHUh?=
Daoy NYjHUpRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ntPGlEPTB;MkSuNVI3KM7:TR?= NHXPXnlUSU6JRWK=
COR-L23 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTPN3NOUUN3ME2yOE4yPzZ5IN88US=> NEPQbWtUSU6JRWK=
KG-1 NE[1e3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXqzbFViUUN3ME2yOE4yQTJ6IN88US=> M1LUcHNCVkeHUh?=
L-428 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTpempwUUN3ME2yOE42PzlzIN88US=> M3XmNHNCVkeHUh?=
NCI-H520 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH2[W9KSzVyPUK0Mlg5PjFizszN MoS0V2FPT0WU
COLO-792 MljoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LZfGlEPTB;MkWuNlc{OiEQvF2= MVXTRW5ITVJ?
NB12 M134[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ntW2lEPTB;MkWuNlk1PyEQvF2= MXHTRW5ITVJ?
GAK MnOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTzTWM2OD1{NT6yPVY{KM7:TR?= M2K5UXNCVkeHUh?=
SW780 M1K2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULRN3duUUN3ME2yOU4{OjZ2IN88US=> MX3TRW5ITVJ?
GB-1 MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjKTWM2OD1{NT60NFY6KM7:TR?= MXvTRW5ITVJ?
P12-ICHIKAWA M3\1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPoVFJKSzVyPUK1MlQ4QDVizszN NYnJc|d3W0GQR1XS
NCI-H1651 NI\WRY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH0TWM2OD1{NT61PVch|ryP M{PHXHNCVkeHUh?=
KE-37 M1\LRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJ3LkezNVUh|ryP MoDMV2FPT0WU
CCRF-CEM M2rFWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rZ[GlEPTB;MkWuPVY4KM7:TR?= NXnNWnY3W0GQR1XS
SF295 MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLhdGVqUUN3ME2yOk4xPDJ3IN88US=> MUDTRW5ITVJ?
G-361 M1L5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HheWlEPTB;Mk[uNVAzPyEQvF2= NEnzNYZUSU6JRWK=
HOP-92 NFTzeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{H3fWlEPTB;Mk[uNVIzPiEQvF2= NEfURWhUSU6JRWK=
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TE-11 NEmzO4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm2TWM2OD1{Nj63O|UzKM7:TR?= NHyyU2NUSU6JRWK=
NCI-H1304 NWDVfXhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjrWIRsUUN3ME2yOk46OTB6IN88US=> NGLhfnhUSU6JRWK=
SJSA-1 MnqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjHbVRKSzVyPUK3MlAyPzZizszN MWHTRW5ITVJ?
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EW-16 Mni4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJ5LkK5OFch|ryP MY\TRW5ITVJ?
HT-144 MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJ5LkSwN|Ih|ryP MYLTRW5ITVJ?
MHH-ES-1 Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjrT|Q5UUN3ME2yO{41PDR5IN88US=> MXjTRW5ITVJ?
T98G NU\6[JB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHsTWM2OD1{Nz61PFQ3KM7:TR?= NXHicVgxW0GQR1XS
RPMI-8866 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJ5Lke1OlIh|ryP M{PycHNCVkeHUh?=
BEN M3Oz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIewUmZKSzVyPUK3Mlg2OTdizszN NHLWWJJUSU6JRWK=
MDA-MB-231 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrTTWM2OD1{OD6yO|k2KM7:TR?= MYjTRW5ITVJ?
HuH-7 NVHWU252T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDXdmxKSzVyPUK4MlQxOjhizszN NVu2NHpFW0GQR1XS
SK-N-FI MnTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[xW2ZKSzVyPUK4MlQ{OyEQvF2= MlyyV2FPT0WU
AN3-CA MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXVeIpbUUN3ME2yPE41Ozl3IN88US=> NHLqbI9USU6JRWK=
EGI-1 Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnodFV5UUN3ME2yPE42QTJ6IN88US=> NF3lcoZUSU6JRWK=
697 NHfuXWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYr6d2Q3UUN3ME2yPE43OzNzIN88US=> M1\v[3NCVkeHUh?=
TCCSUP NFe1fFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK3b3NKSzVyPUK4MlY1OThizszN MWLTRW5ITVJ?
GR-ST M3rNPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFT0blNKSzVyPUK4MlY3QTZizszN M{XwRXNCVkeHUh?=
SK-N-DZ M1XiTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vJe2lEPTB;MkiuOlg5PSEQvF2= M1X6bXNCVkeHUh?=
MIA-PaCa-2 Ml7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXaR|R5UUN3ME2yPE44QTV7IN88US=> NYKwS3E6W0GQR1XS
IGR-1 NH\YenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDPTWM2OD1{OD64PFc1KM7:TR?= NHrncplUSU6JRWK=
BFTC-905 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJ7LkK3NFUh|ryP NHnOXJhUSU6JRWK=
NCI-H1581 NEjiRmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\Yb5ZjUUN3ME2yPU4{OTR3IN88US=> MlPlV2FPT0WU
RD NFOxd4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;pbmlEPTB;MkmuOVI{OyEQvF2= MknNV2FPT0WU
SF268 MlXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3ZTWM2OD1{OT61PVMyKM7:TR?= MmDPV2FPT0WU
SHP-77 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTVTWM2OD1{OT62NVgzKM7:TR?= NYHGN2JGW0GQR1XS
D-566MG MkHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJ7LkmzPVMh|ryP MonBV2FPT0WU
TGBC1TKB MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTNyLkGyN|gh|ryP NGe5W2tUSU6JRWK=
MEL-HO M{LDUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[zTWlEPTB;M{CuNVQzOyEQvF2= Mm[4V2FPT0WU
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D-336MG NHjndlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjoTVNbUUN3ME2zNE4zQDl{IN88US=> NFfOOHpUSU6JRWK=
C3A MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fTWWlEPTB;M{CuNlkzPyEQvF2= MoL5V2FPT0WU
Calu-6 NXrnVZNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[5TWM2OD1|MD6yPVY{KM7:TR?= NFnvb2hUSU6JRWK=
MZ1-PC Ml31S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjEflRYUUN3ME2zNE4{QTNizszN MUHTRW5ITVJ?
KYSE-70 NWniTldUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLyTWM2OD1|MD61NVE1KM7:TR?= NGTmepBUSU6JRWK=
CAPAN-1 MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm1Uo9KSzVyPUOwMlUyQDFizszN MUjTRW5ITVJ?
DK-MG MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjsc49KSzVyPUOwMlU1PTZizszN M3;pe3NCVkeHUh?=
SK-HEP-1 NV\MSY1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTNyLk[zNlYh|ryP MnzIV2FPT0WU
MS-1 NI\yNlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\RR2NrUUN3ME2zNE45QDh7IN88US=> MUTTRW5ITVJ?
GI-ME-N M{jlc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTNzLkC1O|Eh|ryP MlvmV2FPT0WU
NCI-H510A MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW5bXV1UUN3ME2zNU41ODB4IN88US=> Mn3KV2FPT0WU
NB17 NE\uPJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWq5fmlRUUN3ME2zNU42OTh3IN88US=> MnHNV2FPT0WU
639-V NYLJd4VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTTVGFKSzVyPUOxMlUzPDNizszN M1LsWXNCVkeHUh?=
CAL-51 M332OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNzLkW2Olch|ryP NV7sOnhjW0GQR1XS
HGC-27 NIH6dYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7KfJBKSzVyPUOxMlU5PzNizszN NG\mWHBUSU6JRWK=
GOTO M33NbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ITWM2OD1|MT64OVA3KM7:TR?= NWWwbGNuW0GQR1XS
ChaGo-K-1 M{nHZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTN{LkCwO{DPxE1? NV\HSHRjW0GQR1XS
RO82-W-1 NG\pW3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PzdWlEPTB;M{KuNVYxPCEQvF2= MYnTRW5ITVJ?
SH-4 M1nNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn5SYNUUUN3ME2zNk4yQDV6IN88US=> NIXFO4lUSU6JRWK=
A204 Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHsSZc1UUN3ME2zNk42ODZ7IN88US=> M4eyU3NCVkeHUh?=
DMS-273 NUXyNpRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPOTWM2OD1|Mj61N|IzKM7:TR?= NGTlZXhUSU6JRWK=
KGN MmL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TEZ2lEPTB;M{KuOlM{KM7:TR?= M1f3[nNCVkeHUh?=
SK-MEL-2 NW\YO3dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTN{Lk[1Nlch|ryP MVTTRW5ITVJ?
NCI-H2228 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknQTWM2OD1|Mj62OlAzKM7:TR?= Mlq1V2FPT0WU
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ATN-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULjV4RxUUN3ME2zN{4yPDF4IN88US=> MnjvV2FPT0WU
D-263MG MkjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MomxTWM2OD1|Mz64N|c5KM7:TR?= Mk[3V2FPT0WU
LU-135 M1zRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1eyZWlEPTB;M{OuPFgzQSEQvF2= MXTTRW5ITVJ?
C8166 NYPwWI9sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX2OmQ{UUN3ME2zN{45QDV2IN88US=> MYPTRW5ITVJ?
T-24 M3zzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33JVWlEPTB;M{SuNFIxPSEQvF2= M2fXcnNCVkeHUh?=
Mewo NUnHWY57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PyN2lEPTB;M{SuNVM1QSEQvF2= M{nOUnNCVkeHUh?=
22RV1 NFG4fWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjNTWM2OD1|ND6xO|U1KM7:TR?= Mn73V2FPT0WU
KM-H2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS4TWM2OD1|ND6xO|c6KM7:TR?= NEn1fVNUSU6JRWK=
NCI-H2122 M3;3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf3b4F{UUN3ME2zOE4{PDdzIN88US=> NIH1PHdUSU6JRWK=
ABC-1 NW\iXG9XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPaTWM2OD1|ND6zOlk{KM7:TR?= NVzoS4pEW0GQR1XS
NCI-H1355 MlXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTN2LkO4PFkh|ryP MkfYV2FPT0WU
NOMO-1 M1T3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HiZmlEPTB;M{SuOVcxOyEQvF2= MWDTRW5ITVJ?
MZ7-mel MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXuSIFVUUN3ME2zOE43PDh5IN88US=> MkOxV2FPT0WU
NCI-H810 Ml3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf3THpKSzVyPUO0MlczPzhizszN NYSwfnF3W0GQR1XS
D-392MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[1NGlEPTB;M{WuNFU3PSEQvF2= MnHkV2FPT0WU
LB771-HNC MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DyR2lEPTB;M{WuNVY2QCEQvF2= NFPDVo5USU6JRWK=
COLO-679 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTN3LkO4PEDPxE1? NWLtOVVkW0GQR1XS
SK-PN-DW MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnhfJRKSzVyPUO1MlQ{PjlizszN NGW2RoRUSU6JRWK=
VA-ES-BJ MmiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTN3LkS2OFkh|ryP M13WPHNCVkeHUh?=
KNS-42 MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;SXWRmUUN3ME2zOU42QDJ4IN88US=> MYTTRW5ITVJ?
RVH-421 NYfU[VVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFG2dWxKSzVyPUO1Mlc3PDVizszN NIfFdZdUSU6JRWK=
P30-OHK NUHJWm5ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTN3Lki3OVIh|ryP M2X2SXNCVkeHUh?=
G-402 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzjNY1XUUN3ME2zOU46QDZ5IN88US=> NWT2N4RbW0GQR1XS
S-117 M4XHXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvPdoVKSzVyPUO2MlMxODhizszN MWjTRW5ITVJ?
RXF393 MoHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFqx[YhKSzVyPUO2MlM4QDVizszN NXTFWnROW0GQR1XS
LCLC-103H MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIX2dYhKSzVyPUO2Mlc5ODNizszN MX;TRW5ITVJ?
U-118-MG NYPYUW1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTN4Lki4OFch|ryP M1vINHNCVkeHUh?=
8-MG-BA MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTN4Lkm0PFMh|ryP NGr2dYJUSU6JRWK=
MFH-ino NWL4Tot2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PQNWlEPTB;M{euN|M4OSEQvF2= NWOyNosxW0GQR1XS
NCI-H23 NGfzeG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX2TWM2OD1|Nz60NVk3KM7:TR?= MVrTRW5ITVJ?
NCI-H446 NFzYbI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzVd3pKSzVyPUO3MlQ5PjJizszN NUj4PZp7W0GQR1XS
LU-99A NGXGNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX6V2JLUUN3ME2zO{42PzNzIN88US=> MXrTRW5ITVJ?
KP-N-YN NVfE[HlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrNdFRWUUN3ME2zO{43OTl3IN88US=> NF2yN|FUSU6JRWK=
SCC-9 MonGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInvUXNKSzVyPUO3Mlc5OzhizszN NI[xSHNUSU6JRWK=
EFM-19 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorhTWM2OD1|Nz63PVY4KM7:TR?= MXjTRW5ITVJ?
A427 NYHie3ZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTN5LkmxNFch|ryP M2H3S3NCVkeHUh?=
LB831-BLC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[3XnlSUUN3ME2zPE43ODN7IN88US=> M1PU[3NCVkeHUh?=
HOS NGTFSFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTN7Lk[yO|Mh|ryP MVTTRW5ITVJ?
LAN-6 NF;tc|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXzTWM2OD12MD6wNVEzKM7:TR?= MXjTRW5ITVJ?
U251 NILjO5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTRyLkSwOVQh|ryP NYLnToZVW0GQR1XS
SNU-387 NYnrcpJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTRyLkS1OVMh|ryP Mn34V2FPT0WU
DMS-79 NImzPYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLSTWM2OD12MD61PFg6KM7:TR?= NEPTdmlUSU6JRWK=
SK-LU-1 M2PjU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33RdmlEPTB;NECuOlU3QCEQvF2= MVjTRW5ITVJ?
HT MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGwTWM2OD12MD62OlM6KM7:TR?= M1\iR3NCVkeHUh?=
KP-N-YS NGHPeXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[4cWlEPTB;NECuOlc3QCEQvF2= NFqydI9USU6JRWK=
DMS-114 NH7ZflRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTRyLkizO|Qh|ryP NFnDbpVUSU6JRWK=
HUTU-80 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPqOI9KSzVyPUSxMlA2PjlizszN MkD2V2FPT0WU
ONS-76 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33seGlEPTB;NEGuOFcxQSEQvF2= NIHTXmpUSU6JRWK=
A673 NWfC[4dsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTRzLkWxOVch|ryP NHPKdoFUSU6JRWK=
HPAF-II MnywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnW3TWM2OD12MT62O|A6KM7:TR?= Mn3mV2FPT0WU
UACC-257 M4HWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG3fmZlUUN3ME20NU44OzZ7IN88US=> MnrlV2FPT0WU
EW-22 NFniOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrLfJhKSzVyPUSxMlg3QTdizszN NEDrS2VUSU6JRWK=
NCI-H1755 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\r[2lEPTB;NEGuPFczPSEQvF2= Mki2V2FPT0WU
KYSE-150 M4DuV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fDVWlEPTB;NEKuNVc5OiEQvF2= MlL5V2FPT0WU
CGTH-W-1 M2HSTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXWTWM2OD12Mj60PVU2KM7:TR?= NWHaVoJWW0GQR1XS
NB13 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33TO2lEPTB;NEKuOlIyPyEQvF2= MmL3V2FPT0WU
SW872 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mne5TWM2OD12Mj62N|MyKM7:TR?= M3q5[HNCVkeHUh?=
KP-4 NUnJTWdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3XOJB[UUN3ME20Nk45QDN{IN88US=> MmfUV2FPT0WU
HCC38 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHUTWM2OD12Mj65OlE5KM7:TR?= Moi5V2FPT0WU
BB49-HNC NVXRUXRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPvOoZKSzVyPUSzMlI{PTZizszN M4HkNXNCVkeHUh?=
CAL-62 M4\G[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTR|LkSwNlgh|ryP MlHTV2FPT0WU
NCI-H2029 M3fKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHzTWM2OD12Mz61OVgyKM7:TR?= M3m0RnNCVkeHUh?=
M14 NHjTNJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDVOo9KSzVyPUS0MlE{OzJizszN MnjDV2FPT0WU
COLO-680N MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoD4TWM2OD12ND6zN|kh|ryP NYnO[41zW0GQR1XS
Hs-578-T M2XSZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rKRWlEPTB;NEWuNFI6PCEQvF2= MV;TRW5ITVJ?
MSTO-211H NWTNUJNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{foVGlEPTB;NEWuPVQ5OiEQvF2= MknDV2FPT0WU
EW-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j3dmlEPTB;NEWuPVY5QSEQvF2= Mo\rV2FPT0WU
SW948 MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTR4LkS0OlIh|ryP MkXWV2FPT0WU
NCI-H460 NXXXdXhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjmRW5OUUN3ME20Ok42OjNizszN NGnCd41USU6JRWK=
CAS-1 NV71T5NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETBbWRKSzVyPUS2Mlc4ODFizszN NVLxXI1jW0GQR1XS
TGBC11TKB NI\EWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HkdmlEPTB;NEeuNVc4PyEQvF2= MYDTRW5ITVJ?
HD-MY-Z MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTR6Lke4OkDPxE1? NYm4eVd{W0GQR1XS
NCI-H226 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnEflVKSzVyPUS5Mlc4QDVizszN NEX5dXVUSU6JRWK=
PA-1 MoDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTR7LkizN|Uh|ryP NX;pNJpTW0GQR1XS
LB2518-MEL NU\rWoR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES2Oo9KSzVyPUS5Mlg4OjNizszN MkPIV2FPT0WU
A101D NHniZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDkXok3UUN3ME20PU46PDJ3IN88US=> NETjUJJUSU6JRWK=
NCI-H2087 M{LFTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPHTVZOUUN3ME20PU46Pjh{IN88US=> Ml\XV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

+ Expand
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02780687 Recruiting Urologic Neoplasms Boehringer Ingelheim June 9 2016 Phase 2
NCT02131259 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim May 7 2014 --
NCT02216617 Completed HNSCC Groupe Oncologie Radiotherapie Tete et Cou August 6 2014 Phase 1
NCT02451553 Recruiting Advanced Malignant Solid Neoplasm|Bile Duct Carcinoma|Recurrent Malignant Solid Neoplasm|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer AJCC v6 and v7|Stage IVA Pancreatic Cancer|Stage IVB Pancreatic Cancer University of Washington|National Cancer Institute (NCI) November 5 2015 Phase 1
NCT01523587 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim March 5 2012 Phase 3
NCT01345682 Completed Head and Neck Neoplasms|Carcinoma Squamous Cell Boehringer Ingelheim January 5 2012 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID