Afatinib (BIBW2992)

For research use only.

Catalog No.S1011

204 publications

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.

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Selleck's Afatinib (BIBW2992) has been cited by 204 publications

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 NGPDfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3yXVhKSzVyPUCuNFA2PzJizszN M4HXSnNCVkeHUh?=
KASUMI-1 NH;mTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\IRmlEPTB;MD6wNFkyOSEQvF2= MmrEV2FPT0WU
HCC2218 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rnXWlEPTB;MD6wNFk5PyEQvF2= NILFOotUSU6JRWK=
KARPAS-45 NFLs[FBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LjfGlEPTB;MD6wNVY4OSEQvF2= MmPqV2FPT0WU
HSC-4 MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj6VYZKSzVyPUCuNFE4PDhizszN M1HxZXNCVkeHUh?=
CHL-1 NYDIPJFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEG4N|kh|ryP NXfXdHFYW0GQR1XS
KY821 Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYixUZZ6UUN3ME2wMlAzODZizszN M3zKNXNCVkeHUh?=
NCI-N87 NH3hSZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYq3fnFVUUN3ME2wMlAzPzd|IN88US=> NXPKV5BPW0GQR1XS
DOK MofpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\COmlEPTB;MD6wN|E6PCEQvF2= NV3uZ3FvW0GQR1XS
DSH1 MoDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMEOzNVQh|ryP M2DNbnNCVkeHUh?=
MDA-MB-175-VII MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMEO0NVYh|ryP NWi0SpNVW0GQR1XS
NCI-H2170 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj6emVKSzVyPUCuNFM4OjhizszN NEHoRpNUSU6JRWK=
BT-474 NEG1NJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMES5PFYh|ryP MVXTRW5ITVJ?
EFO-27 NH;0fGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\Cd2lEPTB;MD6wOVE5OiEQvF2= M2Txd3NCVkeHUh?=
NCI-H720 M2Xme2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr4W203UUN3ME2wMlA2OzJ3IN88US=> NGXlRoZUSU6JRWK=
PC-14 NF;u[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLHUZZKSzVyPUCuNFU3PjhizszN NYezdYxxW0GQR1XS
EC-GI-10 NGnZXIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjiemFKSzVyPUCuNFU6OTJizszN NYjiUnVxW0GQR1XS
KYSE-450 M12xXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfVWWZXUUN3ME2wMlA2QTd6IN88US=> NWj2TpJIW0GQR1XS
BPH-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\NSHRkUUN3ME2wMlA2QTh6IN88US=> NYqxdIxCW0GQR1XS
NCI-H292 M1f5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwME[wPUDPxE1? MnH5V2FPT0WU
H9 NFrqeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTsOppKSzVyPUCuNFcyOzJizszN NGHuWplUSU6JRWK=
NCI-H526 M3XySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLmPGlKSzVyPUCuNFc5OjNizszN MXHTRW5ITVJ?
NCI-H1623 MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPaW5JVUUN3ME2wMlA5ODJ3IN88US=> NF36c3lUSU6JRWK=
KYSE-140 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEizN{DPxE1? M2DVd3NCVkeHUh?=
Ca9-22 M1;tZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\h[FlKSzVyPUCuNFg{PTNizszN MoPoV2FPT0WU
AU565 NWfod4VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInucZRKSzVyPUCuNFg2ODRizszN Mmr4V2FPT0WU
ZR-75-30 MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPqRm1KSzVyPUCuNFk2PDVizszN MUPTRW5ITVJ?
NCI-H1770 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzCTWM2OD1yLkGwNlgh|ryP NFjUWIJUSU6JRWK=
LB2241-RCC M2nrd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTBwMUC4PFQh|ryP MofrV2FPT0WU
CAL-39 MnnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLnN49wUUN3ME2wMlEyPzl{IN88US=> NHP0dG9USU6JRWK=
UACC-893 M{OyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXvXpp[UUN3ME2wMlEyQDh3IN88US=> MmrIV2FPT0WU
LU-65 M1LXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i3dmlEPTB;MD6xNlY{OyEQvF2= MYPTRW5ITVJ?
HN NH3qeHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInSXYFKSzVyPUCuNVMxPzdizszN NGHyNoVUSU6JRWK=
TI-73 NF\SW4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;MT2lEPTB;MD6xOFcyPSEQvF2= M{LIUHNCVkeHUh?=
KU812 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3xU2xKSzVyPUCuNVU1PTZizszN NFLJSmlUSU6JRWK=
SW13 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEKxeGJKSzVyPUCuNVYzOTZizszN NHTqUZJUSU6JRWK=
BB30-HNC M{\tXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMU[1O|Yh|ryP MXPTRW5ITVJ?
HSC-2 NWfVZZBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TFV2lEPTB;MD6xOlg{PyEQvF2= MYPTRW5ITVJ?
BV-173 MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HUN2lEPTB;MD6xO|U6PiEQvF2= NFHpS2lUSU6JRWK=
CAL-27 M2rrUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLtNoRKSzVyPUCuNVc3OzZizszN MnT3V2FPT0WU
SBC-1 M4PBR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfKZWVKSzVyPUCuNVg6PTlizszN M{\0b3NCVkeHUh?=
CAL-33 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjHOVF7UUN3ME2wMlIxOTh2IN88US=> M2jkWXNCVkeHUh?=
NCI-H209 MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnrVY9zUUN3ME2wMlIxPDZizszN Mn\qV2FPT0WU
COR-L105 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWj2UYpWUUN3ME2wMlIyODh2IN88US=> NXuwb2JNW0GQR1XS
HSC-3 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwMkGxPVgh|ryP MnjpV2FPT0WU
NCI-H69 NUPlfYNrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H6ZWlEPTB;MD6yNVQ2OSEQvF2= M2LyUXNCVkeHUh?=
MOLT-13 NHXH[IxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXyTWM2OD1yLkKzPVc2KM7:TR?= NUnidFB[W0GQR1XS
ML-2 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrDZ29KSzVyPUCuNlQ5ODJizszN NGjiUo5USU6JRWK=
IGROV-1 NH\2N2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\xTWM2OD1yLkK1PVUzKM7:TR?= NYTTXXo4W0GQR1XS
TK10 MlHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE[wRnZKSzVyPUCuNlY4OzhizszN MV3TRW5ITVJ?
EoL-1-cell MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f5XGlEPTB;MD6yOlg6OiEQvF2= M4HNZnNCVkeHUh?=
HO-1-N-1 NU\CdmF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjocYhrUUN3ME2wMlI4QDV|IN88US=> M3mw[3NCVkeHUh?=
BHY NVHOUHp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwMki2OVUh|ryP MV;TRW5ITVJ?
LU-139 MofmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LuWmlEPTB;MD6zNFUyKM7:TR?= NIHJdI9USU6JRWK=
23132-87 NY\NPHVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELYdnpKSzVyPUCuN|E6OjNizszN MVXTRW5ITVJ?
ACHN NFXFbYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jhNGlEPTB;MD6zNVk6PCEQvF2= NULs[|BuW0GQR1XS
DoTc2-4510 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLzTWM2OD1yLkOyNlE6KM7:TR?= MVTTRW5ITVJ?
BB65-RCC M2XiO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfseo5sUUN3ME2wMlM1PTl|IN88US=> MknYV2FPT0WU
HLE MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkSyTWM2OD1yLkO1NFQ3KM7:TR?= NHO3XY1USU6JRWK=
HCC1419 NHzhXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrFdYVKSzVyPUCuN|Y1ODhizszN Mn7iV2FPT0WU
A388 NWP0TmdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3W3dmlEPTB;MD6zOlg2PyEQvF2= M1XMV3NCVkeHUh?=
NUGC-3 Mlm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TS[mlEPTB;MD6zPFM4OyEQvF2= NFv4V2NUSU6JRWK=
KYSE-180 NXjlOJN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwM{mwPFkh|ryP M1nzUHNCVkeHUh?=
TE-6 MkGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjvTVdKSzVyPUCuOFAzPDZizszN MVHTRW5ITVJ?
A498 M2KxOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwNEC2O|Qh|ryP NHfKdldUSU6JRWK=
NCI-H1648 M3T5dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXzTWM2OD1yLkS0NVgzKM7:TR?= NFPDR|FUSU6JRWK=
DU-145 NGHRXmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i0UWlEPTB;MD60OFg{OyEQvF2= M160PHNCVkeHUh?=
CW-2 MoD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwNE[5NVQh|ryP NWTiTmdKW0GQR1XS
A431 M3nremdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrje5BIUUN3ME2wMlQ5OjN|IN88US=> NGXMeXdUSU6JRWK=
SAS MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnVe2FWUUN3ME2wMlQ5Ozl6IN88US=> M{HrSXNCVkeHUh?=
NCI-H2126 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwNUG5NlYh|ryP Mlr5V2FPT0WU
NCI-H358 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwNUOyNUDPxE1? NGfrWlRUSU6JRWK=
FADU MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fGXmlEPTB;MD61OFQxPCEQvF2= NHvCPGZUSU6JRWK=
ACN NVeyOYg5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XZOmlEPTB;MD61OVA6PCEQvF2= NWK2O|I4W0GQR1XS
HCC70 NHH2UG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmr2TWM2OD1yLkW3OlYyKM7:TR?= M1n0UHNCVkeHUh?=
NCI-H1838 NFTEVHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwNkCyPVkh|ryP MXjTRW5ITVJ?
CAL-54 M{jVcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTwRlNxUUN3ME2wMlYyPjJzIN88US=> MWfTRW5ITVJ?
NCI-H1975 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4j3O2lEPTB;MD62NVczQCEQvF2= NHLtXppUSU6JRWK=
COR-L88 M2f0bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwNkSxNVMh|ryP M{LKSXNCVkeHUh?=
CTV-1 M4HPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFG0TJNKSzVyPUCuOlQ{QTJizszN MlzaV2FPT0WU
EW-18 MmrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH5SotKSzVyPUCuOlg3QThizszN M1zaXHNCVkeHUh?=
HCC1806 MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwNkm2OlYh|ryP NH;TSHhUSU6JRWK=
HuP-T4 NXXjUmduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDFbmx2UUN3ME2wMlY6PzZizszN M{DmT3NCVkeHUh?=
MDA-MB-361 NIe3fZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlz0TWM2OD1yLkeyOlYzKM7:TR?= NUPFd2NsW0GQR1XS
NCI-H1573 NECyRmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1W5[GlEPTB;MD63N|Y{KM7:TR?= NVPK[406W0GQR1XS
KU-19-19 MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnWxTWM2OD1yLke3OFY1KM7:TR?= Mn62V2FPT0WU
COLO-678 NH7pOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwOEC4N|Qh|ryP MYfTRW5ITVJ?
C-33-A MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjaVJI5UUN3ME2wMlgyOjl5IN88US=> M4HhV3NCVkeHUh?=
Calu-3 NXPGc5c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LVXGlEPTB;MD64NVQ{PCEQvF2= NXPMXFBEW0GQR1XS
AGS MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\NTWM2OD1yLkizOlQ5KM7:TR?= NGHoRpRUSU6JRWK=
SCC-25 Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\DTWM2OD1yLki0NVcyKM7:TR?= MXjTRW5ITVJ?
JVM-2 MmToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj3TWM2OD1yLki4Nlk6KM7:TR?= M4fGRXNCVkeHUh?=
HCE-T MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjkNmJUUUN3ME2wMlg5PDJ6IN88US=> NFm0XWRUSU6JRWK=
ES4 NHjIe4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwOUe4N|Yh|ryP M3zV[HNCVkeHUh?=
EKVX NXHNPG5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nBeWlEPTB;MT6wNVA3PCEQvF2= MUfTRW5ITVJ?
D-542MG M17pZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTFwMEGwOlQh|ryP MXLTRW5ITVJ?
SW1116 NVvmc|RGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7vNGZGUUN3ME2xMlAyOjh5IN88US=> NEPJ[mhUSU6JRWK=
5637 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvSNmg2UUN3ME2xMlAyPTFizszN MorWV2FPT0WU
HT-1376 NV:ydINpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XsTmlEPTB;MT6wNVUyOyEQvF2= NI\qeHZUSU6JRWK=
NB69 NGCzfmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zJXmlEPTB;MT6wNlk1PSEQvF2= NHn0[JBUSU6JRWK=
YKG-1 NGfON|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;yTWM2OD1zLkC1OFE6KM7:TR?= NVrSfIt1W0GQR1XS
EW-3 MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXN[5ZKSzVyPUGuNFc5QDNizszN MWnTRW5ITVJ?
GCIY NIPU[VlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nXeGlEPTB;MT6wPFExPCEQvF2= MnuyV2FPT0WU
SK-MES-1 NF:2Z5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jwPWlEPTB;MT6xNVQ5PyEQvF2= M4ThVHNCVkeHUh?=
PANC-08-13 MlrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;P[IpKSzVyPUGuNVY1OTZizszN MXTTRW5ITVJ?
SK-NEP-1 M1TSN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXiTWM2OD1zLkG3OVE{KM7:TR?= NInUXWRUSU6JRWK=
SW954 NVnqWJBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLWWYJmUUN3ME2xMlIxOjF2IN88US=> NWLHSYlFW0GQR1XS
NCI-SNU-5 M2LUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTFwMkO5JO69VQ>? NYL0VJcyW0GQR1XS
SW48 M3m5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzkb5NRUUN3ME2xMlI2PDN{IN88US=> M3m4bHNCVkeHUh?=
HT-3 MmLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLRepdVUUN3ME2xMlI5PzV|IN88US=> MYLTRW5ITVJ?
ETK-1 MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnKTWM2OD1zLkO3OFU3KM7:TR?= MV3TRW5ITVJ?
SCC-15 NF36UJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX71N3lUUUN3ME2xMlM6PDVzIN88US=> M4j5cHNCVkeHUh?=
DU-4475 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPDPHh5UUN3ME2xMlQxOTJzIN88US=> NHW5fIdUSU6JRWK=
NB5 M3G1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq4TlhLUUN3ME2xMlQyOzF5IN88US=> M3nDZXNCVkeHUh?=
CFPAC-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPidVlMUUN3ME2xMlQzPDl|IN88US=> NXjqSJl3W0GQR1XS
NCI-H630 NID5VXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTFwNEW1PFIh|ryP NGjp[GhUSU6JRWK=
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D-502MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3S2ZmlEPTB;OD6yPVI5OiEQvF2= NHfvb|dUSU6JRWK=
NCI-H1993 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXWe3p3UUN3ME24MlM{PjNzIN88US=> MVHTRW5ITVJ?
SCC-4 NWrsRYF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPZTWM2OD16LkS0NFU6KM7:TR?= Mo\QV2FPT0WU
HAL-01 NUT3XnY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRThwNUG5NUDPxE1? NFLhR5NUSU6JRWK=
GT3TKB MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\0V2lEPTB;OD62O|k3PCEQvF2= NHXrTIxUSU6JRWK=
SK-OV-3 NH7NR3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfUPFhKSzVyPUiuO|E{OjlizszN MV7TRW5ITVJ?
COLO-829 M2\6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;IbmtOUUN3ME24MlgxQTd4IN88US=> MXvTRW5ITVJ?
OCI-AML2 MnK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPkeJV{UUN3ME24Mlk2PDhzIN88US=> NXTre3l5W0GQR1XS
OS-RC-2 NXn5SYQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfscXpzUUN3ME25MlAzOTlizszN MWDTRW5ITVJ?
BFTC-909 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTlwME[3PVkh|ryP NUDmfWs{W0GQR1XS
EW-11 NGrEcYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILjelBKSzVyPUmuNVc3PTNizszN Mo\iV2FPT0WU
HCE-4 M2PuXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTlwMkG1OVgh|ryP MoT1V2FPT0WU
BALL-1 NITsRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPhTWM2OD17LkKxPVA4KM7:TR?= M3PzVnNCVkeHUh?=
SF539 NXHMN3U6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzRTWM2OD17LkKzOVYzKM7:TR?= M4\W[XNCVkeHUh?=
CAMA-1 MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkf6TWM2OD17LkK4NVI5KM7:TR?= MXXTRW5ITVJ?
C32 NX3wN4dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTlwM{OwOlQh|ryP MY\TRW5ITVJ?
NCI-H1703 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzBbXRKSzVyPUmuN|Q{PzVizszN MXTTRW5ITVJ?
NCI-H1650 NE[1NlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPBbWdKSzVyPUmuOlA6PDZizszN M1rnbXNCVkeHUh?=
NCI-H1563 M2\OSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y0S2lEPTB;OT63OlA{OSEQvF2= NGm2TZdUSU6JRWK=
CAL-85-1 Mmq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\Yd3FGUUN3ME25Mlg4Ozh|IN88US=> M1fncnNCVkeHUh?=
UM-UC-3 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\DOIVKSzVyPUmuPVUxOyEQvF2= NYX2NZhLW0GQR1XS
BxPC-3 NFHkblhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLJTWM2OD1zMD6wPVczKM7:TR?= MVzTRW5ITVJ?
MHH-PREB-1 NUfvOmtoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXPTWM2OD1zMD6xPVk6KM7:TR?= MVvTRW5ITVJ?
DEL MlzKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjYTWM2OD1zMD6zPVQ3KM7:TR?= NF7DSZhUSU6JRWK=
HuCCT1 NVHNOnl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjQSFJ[UUN3ME2xNE43ODN|IN88US=> M3vYR3NCVkeHUh?=
OVCAR-4 NV7tU25HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELFSnRKSzVyPUGwMlg5OzVizszN MYTTRW5ITVJ?
CAL-72 MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPyTWM2OD1zMD65N|kyKM7:TR?= M3;Le3NCVkeHUh?=
HCC1954 M4XJRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT4bow2UUN3ME2xNU4xPzV2IN88US=> MX3TRW5ITVJ?
EFO-21 NFO5TpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2i1[GlEPTB;MUGuNVA1PSEQvF2= M2\DUnNCVkeHUh?=
FTC-133 NYnNRndWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTFzLkG0NFch|ryP NGq5UXhUSU6JRWK=
SK-MEL-24 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTFzLkKzOlYh|ryP M{\4RnNCVkeHUh?=
UACC-62 NXn4TFdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PXOmlEPTB;MUGuNlM3QCEQvF2= NVP6[|lyW0GQR1XS
NCI-H650 MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTKTWM2OD1zMT6yOFE5KM7:TR?= Ml3qV2FPT0WU
ALL-PO MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTFzLkK1NVIh|ryP MmHRV2FPT0WU
T84 M4PKbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFzLkO5NFch|ryP M1HGV3NCVkeHUh?=
IST-MEL1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFzLkS1OVkh|ryP Mk\1V2FPT0WU
SW626 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Dw[WlEPTB;MUGuOVc2PSEQvF2= MlHrV2FPT0WU
RPMI-2650 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnwXpZKSzVyPUGxMlU5QDVizszN NWKzUoh{W0GQR1XS
MC-IXC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\NcWlEPTB;MUGuOlczQCEQvF2= NWP3UVhjW0GQR1XS
HOP-62 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzM[oh6UUN3ME2xNU43PzZ2IN88US=> NXfSSFB7W0GQR1XS
NOS-1 NYfJelFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknwTWM2OD1zMT63NVA6KM7:TR?= NIrDOXZUSU6JRWK=
SW1573 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTFzLkeyPVUh|ryP MWLTRW5ITVJ?
WM-115 NGXRR|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDTb25HUUN3ME2xNU44PTh6IN88US=> M2nKVnNCVkeHUh?=
HuO9 NF;Q[FJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTFzLki3O|Qh|ryP M4Tv[HNCVkeHUh?=
YAPC Ml7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XXbGlEPTB;MUGuPVI2QSEQvF2= M4LZSnNCVkeHUh?=
MDA-MB-453 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHKb3Q4UUN3ME2xNU46PTF3IN88US=> MVHTRW5ITVJ?
NCI-H596 NF\Cd2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX4NWRKSzVyPUGyMlA{PjlizszN NELNbmVUSU6JRWK=
A172 M2q4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2CwW2lEPTB;MUKuNFc6QCEQvF2= M3v4SnNCVkeHUh?=
RS4-11 NF;nfGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPYTWM2OD1zMj6xO|I2KM7:TR?= NGrxOXVUSU6JRWK=
HCC1937 NFnyOVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjGV2tKSzVyPUGyMlc2PjRizszN M1rycHNCVkeHUh?=
SW837 M1LlTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTF{LkmwNlgh|ryP NFLNeVdUSU6JRWK=
NMC-G1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT0TWM2OD1zMj65NlM1KM7:TR?= NILCbYpUSU6JRWK=
PFSK-1 NF36dmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfkNZJKSzVyPUGzMlA3KM7:TR?= NGj5Z4RUSU6JRWK=
DBTRG-05MG Ml7kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7Sb2NHUUN3ME2xN{4xPjN{IN88US=> NV;jOmlzW0GQR1XS
SK-UT-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTF|LkGwPFMh|ryP NXr3[FhZW0GQR1XS
OVCAR-5 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnj[5RyUUN3ME2xN{4yPTl|IN88US=> Mkf6V2FPT0WU
8505C NFnmNJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTF|LkKwOlch|ryP MkDSV2FPT0WU
SK-MEL-1 NWLHeXRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLKTWM2OD1zMz63NVM2KM7:TR?= M{fycXNCVkeHUh?=
LK-2 M2Do[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF|Lke2N|kh|ryP NIntdVVUSU6JRWK=
OE33 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF|Lke4OkDPxE1? MkHEV2FPT0WU
Ramos-2G6-4C10 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{K5b2lEPTB;MUSuNFIxOiEQvF2= MnzVV2FPT0WU
EW-13 M{jTeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTF2LkCzOVIh|ryP MXvTRW5ITVJ?
NCI-H1793 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXSbXB7UUN3ME2xOE4zODh5IN88US=> NV65RnV5W0GQR1XS
BHT-101 M2fHfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF2LkK0NUDPxE1? MUfTRW5ITVJ?
RKO MmXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjXW4lKSzVyPUG0MlUxPzVizszN M{WwcnNCVkeHUh?=
NEC8 NFn6VZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIqzVGFKSzVyPUG0MlU1PzJizszN MV\TRW5ITVJ?
PANC-10-05 MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF2Lk[yOFch|ryP NUOyNVJCW0GQR1XS
NCI-H2030 NHvNSVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHSTWM2OD1zND62OFQ5KM7:TR?= MYTTRW5ITVJ?
C2BBe1 M3nkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjre|RKSzVyPUG0Mlc3PCEQvF2= NYHVTG1pW0GQR1XS
EM-2 NHzQZVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\oOGlEPTB;MUSuPFU4PiEQvF2= M{S0dXNCVkeHUh?=
HCC1395 M4roRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HhOmlEPTB;MUSuPVM{QCEQvF2= MYnTRW5ITVJ?
A2058 NF3k[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnGyTWM2OD1zNT6wOFA6KM7:TR?= MVjTRW5ITVJ?
SW1463 MlS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHLfIZQUUN3ME2xOU4xPDh3IN88US=> NULIe5ZIW0GQR1XS
J82 NHHQWoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G1SmlEPTB;MUWuNFU4KM7:TR?= MonpV2FPT0WU
CAL-120 M1TOc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXteFZRUUN3ME2xOU4yPDR5IN88US=> M1LldXNCVkeHUh?=
COLO-824 NV7SU3htT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:1eVBKSzVyPUG1MlE2PzlizszN M4jpV3NCVkeHUh?=
LNCaP-Clone-FGC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLRTWM2OD1zNT60NlQ5KM7:TR?= NIWzW|lUSU6JRWK=
CP66-MEL NIfXdJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLZVotKSzVyPUG1MlQ3QDhizszN MnH1V2FPT0WU
OC-314 M3;HXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D3TGlEPTB;MUWuOFcyPCEQvF2= NUPWcnhuW0GQR1XS
OVCAR-8 M1;ZbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[4PG5KSzVyPUG1Mlg5PjFizszN MXTTRW5ITVJ?
MFE-280 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrMTWM2OD1zNj6wOFg5KM7:TR?= NIXuOYNUSU6JRWK=
MHH-NB-11 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTF4LkC4N|kh|ryP NH7EbZBUSU6JRWK=
SW1990 NXq5VIhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3O4eGlEPTB;MU[uNVc2PSEQvF2= Mle3V2FPT0WU
U-266 M{frXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3QeGFKSzVyPUG2MlIzQTlizszN MUHTRW5ITVJ?
MFM-223 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTF4LkO5OlUh|ryP NXXFR5JUW0GQR1XS
L-363 M4rsSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fsXGlEPTB;MU[uOFU4PyEQvF2= NHzQXIZUSU6JRWK=
MCF7 NX\5R2xbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LOcWlEPTB;MU[uOFczOyEQvF2= MXPTRW5ITVJ?
SK-MEL-3 M1TocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTF4LkS3PFch|ryP MWfTRW5ITVJ?
HH Mni4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\NTWM2OD1zNj61NVYzKM7:TR?= M4XnPXNCVkeHUh?=
no-10 MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTF4Lk[zOFMh|ryP M{PEN3NCVkeHUh?=
HuP-T3 M3\hb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LwOmlEPTB;MU[uOlU4PiEQvF2= MVjTRW5ITVJ?
QIMR-WIL M4q5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfXTWM2OD1zNj63NVA2KM7:TR?= NWLYNWlNW0GQR1XS
NCI-H1092 NWXSTGRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzEeJdKSzVyPUG2Mlg{OTZizszN MlTYV2FPT0WU
MZ2-MEL MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX4WWdtUUN3ME2xOk45PDB|IN88US=> MXPTRW5ITVJ?
ES3 MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HLZWlEPTB;MU[uPVE{PCEQvF2= NYPubWhiW0GQR1XS
COLO-684 M4W0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP4TWM2OD1zNj65OFc4KM7:TR?= Mk\JV2FPT0WU
NCI-H661 MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPETWM2OD1zNj65Olk1KM7:TR?= NGTuZlRUSU6JRWK=
CP50-MEL-B NEHhUmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTF5LkCzOFMh|ryP MXnTRW5ITVJ?
NCI-H2405 MkHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\WTWlEPTB;MUeuNVk4PCEQvF2= MXPTRW5ITVJ?
U-2-OS MkW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTF5LkWzNFch|ryP NHvGRZZUSU6JRWK=
RERF-LC-MS NGD4SodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETXUnZKSzVyPUG3MlU2ODhizszN MoDtV2FPT0WU
NCI-H2342 NIHkWINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTF5LkW1O{DPxE1? NHK2PHZUSU6JRWK=
ES8 NX3WNVFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nNO2lEPTB;MUeuOlA5PyEQvF2= MnzNV2FPT0WU
MOLT-16 NWTBW5B3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTF5Lki5N|Qh|ryP NIK5TZdUSU6JRWK=
RH-18 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zYeWlEPTB;MUiuNFA{PSEQvF2= MWnTRW5ITVJ?
D-283MED M{[yXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULX[GsyUUN3ME2xPE4xODh6IN88US=> MYPTRW5ITVJ?
RCC10RGB M3e4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjYTHFVUUN3ME2xPE4xPTV7IN88US=> M1nJU3NCVkeHUh?=
NCI-H1437 NIHITnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTF6LkG2OFEh|ryP NF61dHJUSU6JRWK=
SW982 Mle1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfPTGxDUUN3ME2xPE4zPjdzIN88US=> NV7hT2FMW0GQR1XS
IST-MES1 NVnkV5NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\tcmxVUUN3ME2xPE41PDJ6IN88US=> MUDTRW5ITVJ?
A704 MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;wTWM2OD1zOD60O|U{KM7:TR?= MkDJV2FPT0WU
ESS-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\ObVk5UUN3ME2xPE42OjB3IN88US=> NGC1ZYVUSU6JRWK=
SCH MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTF6Lk[0OVYh|ryP MU\TRW5ITVJ?
COLO-320-HSR NUTabZY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjsTWM2OD1zOD63OFYh|ryP NYDXTpV5W0GQR1XS
Mo-T NUfkdY1PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFO5TFdKSzVyPUG4MlgzODRizszN NHja[FNUSU6JRWK=
Saos-2 Mk\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;HfZNKSzVyPUG5MlEyPjJizszN Mn\1V2FPT0WU
SW684 NXroO|MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\2eplKSzVyPUG5MlE{OjZizszN MXXTRW5ITVJ?
KMOE-2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFv4cZdKSzVyPUG5MlIzPDJizszN NFXVToxUSU6JRWK=
MMAC-SF MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjFPHFKSzVyPUG5MlI3ODdizszN NVPwPW9DW0GQR1XS
JAR NV20cpJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO1e2pkUUN3ME2xPU4zQTlizszN M1TEe3NCVkeHUh?=
SK-MEL-28 NXG0e|dUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDTZpRrUUN3ME2xPU4{OzZ|IN88US=> NVrTbo1wW0GQR1XS
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NCI-H810 Ml3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTN2LkeyO|gh|ryP NXnSRoJyW0GQR1XS
D-392MG NYTZdmFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfrS3lKSzVyPUO1MlA2PjVizszN NU\SUXBtW0GQR1XS
LB771-HNC NYOyNppwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTN3LkG2OVgh|ryP MnrTV2FPT0WU
COLO-679 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfhbXoyUUN3ME2zOU4{QDhizszN MlHHV2FPT0WU
SK-PN-DW M2XoO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTaWHluUUN3ME2zOU41OzZ7IN88US=> MYPTRW5ITVJ?
VA-ES-BJ MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTN3LkS2OFkh|ryP Mmr4V2FPT0WU
KNS-42 M1P3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPBTWM2OD1|NT61PFI3KM7:TR?= NF:0R25USU6JRWK=
RVH-421 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvrTWM2OD1|NT63OlQ2KM7:TR?= NH;YS|JUSU6JRWK=
P30-OHK NXvmZW9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\Sd2lEPTB;M{WuPFc2OiEQvF2= MnPlV2FPT0WU
G-402 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPrTWM2OD1|NT65PFY4KM7:TR?= MVjTRW5ITVJ?
S-117 MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7mWmpKSzVyPUO2MlMxODhizszN MWTTRW5ITVJ?
RXF393 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTN4LkO3PFUh|ryP NGjOUmNUSU6JRWK=
LCLC-103H NVX1W|A6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfu[m5tUUN3ME2zOk44QDB|IN88US=> NXfGcGVGW0GQR1XS
U-118-MG MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTN4Lki4OFch|ryP NV23OZF7W0GQR1XS
8-MG-BA MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;UR2lEPTB;M{[uPVQ5OyEQvF2= MkHxV2FPT0WU
MFH-ino NWHzOJdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{e0[2lEPTB;M{euN|M4OSEQvF2= MXzTRW5ITVJ?
NCI-H23 M4H3NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDxXW4zUUN3ME2zO{41OTl4IN88US=> MWfTRW5ITVJ?
NCI-H446 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7yTWM2OD1|Nz60PFYzKM7:TR?= NGewVVlUSU6JRWK=
LU-99A MnLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjLRZBKSzVyPUO3MlU4OzFizszN M{Xyb3NCVkeHUh?=
KP-N-YN MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTN5Lk[xPVUh|ryP MV\TRW5ITVJ?
SCC-9 NXPFOGhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jqZmlEPTB;M{euO|g{QCEQvF2= NEHLcZdUSU6JRWK=
EFM-19 MoH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTN5Lke5Olch|ryP MnS2V2FPT0WU
A427 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HMbGlEPTB;M{euPVExPyEQvF2= M4D3[XNCVkeHUh?=
LB831-BLC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTN6Lk[wN|kh|ryP MmfRV2FPT0WU
HOS NGm5SVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPXbllKSzVyPUO5MlYzPzNizszN NFvkeWlUSU6JRWK=
LAN-6 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHYboFKSzVyPUSwMlAyOTJizszN M130VXNCVkeHUh?=
U251 NXn0dlA4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnWzTWM2OD12MD60NFU1KM7:TR?= MYXTRW5ITVJ?
SNU-387 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTRyLkS1OVMh|ryP MVrTRW5ITVJ?
DMS-79 NHH1fHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX4c49KSzVyPUSwMlU5QDlizszN Ml:wV2FPT0WU
SK-LU-1 M2D1RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTKTWM2OD12MD62OVY5KM7:TR?= NX;6dFR6W0GQR1XS
HT NUSwdJYzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTRyLk[2N|kh|ryP MlrSV2FPT0WU
KP-N-YS MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTRyLk[3Olgh|ryP NIHOTnhUSU6JRWK=
DMS-114 MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XieGlEPTB;NECuPFM4PCEQvF2= NG[xPFlUSU6JRWK=
HUTU-80 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3K5XGlEPTB;NEGuNFU3QSEQvF2= NHG2SZdUSU6JRWK=
ONS-76 NVOzd3JRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWraVFRbUUN3ME20NU41PzB7IN88US=> NIPKNolUSU6JRWK=
A673 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjWOZFKUUN3ME20NU42OTV5IN88US=> MWLTRW5ITVJ?
HPAF-II Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LaTmlEPTB;NEGuOlcxQSEQvF2= Ml3pV2FPT0WU
UACC-257 NXrlepNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fOXWlEPTB;NEGuO|M3QSEQvF2= M1zqenNCVkeHUh?=
EW-22 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:xTWM2OD12MT64Olk4KM7:TR?= NGXD[YpUSU6JRWK=
NCI-H1755 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTRzLki3NlUh|ryP NE\SXJNUSU6JRWK=
KYSE-150 NGrrN2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\WTWM2OD12Mj6xO|gzKM7:TR?= NYLZOHFXW0GQR1XS
CGTH-W-1 MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfod|lEUUN3ME20Nk41QTV3IN88US=> M1LZSXNCVkeHUh?=
NB13 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3YWHRKSzVyPUSyMlYzOTdizszN Mnu3V2FPT0WU
SW872 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTR{Lk[zN|Eh|ryP NYHTdlF1W0GQR1XS
KP-4 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zjbWlEPTB;NEKuPFg{OiEQvF2= MV7TRW5ITVJ?
HCC38 M{\WWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTR{Lkm2NVgh|ryP NYHpeVJbW0GQR1XS
BB49-HNC M4fZZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGS5T3dKSzVyPUSzMlI{PTZizszN M3job3NCVkeHUh?=
CAL-62 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\qXWJKSzVyPUSzMlQxOjhizszN NFPZVHpUSU6JRWK=
NCI-H2029 NFy2epRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTR|LkW1PFEh|ryP MVXTRW5ITVJ?
M14 NUTtbplkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\ucGlEPTB;NESuNVM{OiEQvF2= NFH1VYRUSU6JRWK=
COLO-680N M4r5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkm5TWM2OD12ND6zN|kh|ryP MniwV2FPT0WU
Hs-578-T NWW1T45ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfJVGFKSzVyPUS1MlAzQTRizszN NEjsfVRUSU6JRWK=
MSTO-211H Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{GyRmlEPTB;NEWuPVQ5OiEQvF2= MVHTRW5ITVJ?
EW-1 NW\H[IlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTR3Lkm2PFkh|ryP MUTTRW5ITVJ?
SW948 Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjrTWM2OD12Nj60OFYzKM7:TR?= Mn7TV2FPT0WU
NCI-H460 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C0OWlEPTB;NE[uOVI{KM7:TR?= M3G0e3NCVkeHUh?=
CAS-1 NUPyc|lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPGTWM2OD12Nj63O|AyKM7:TR?= NH3kXFBUSU6JRWK=
TGBC11TKB NYLnd3JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXMT3RKSzVyPUS3MlE4PzdizszN MWnTRW5ITVJ?
HD-MY-Z MmLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rSR2lEPTB;NEiuO|g3KM7:TR?= M4HsTnNCVkeHUh?=
NCI-H226 MkTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPUTWM2OD12OT63O|g2KM7:TR?= MW\TRW5ITVJ?
PA-1 Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jENmlEPTB;NEmuPFM{PSEQvF2= Mlz4V2FPT0WU
LB2518-MEL NUXTO5ZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvpTWM2OD12OT64O|I{KM7:TR?= NILXdYJUSU6JRWK=
A101D MlTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3RV5lKSzVyPUS5Mlk1OjVizszN MYfTRW5ITVJ?
NCI-H2087 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT1b|V7UUN3ME20PU46Pjh{IN88US=> M4SzbnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

p-VEGFR2 / VEGFR2 / JAG1 / DLL4 / NICD1 ; 

PubMed: 28533486     


HUVECs were cultured in the presence of Vatalanib (100 nM) or DBZ (10 nM) for 1 h and then treated for 15 min with rhgal-3 (37 nM) and cultured for additional 6 hrs. After this period, the total protein was isolated and the protein levels of galectin-3, NICD1, DLL4, JAG1, VEGFR2 and VEGFR2-p were assessed by Western blot. β-actin was used as a loading control.

25537503 26052929 28533486
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

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In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

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  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Athymic NMRI-nu/nu female mice
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Water Insoluble
Ethanol ''15 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 850140-72-6
Storage powder
in solvent
Synonyms N/A
Smiles CN(C)C/C=C/C(=O)NC1=CC2=C(NC3=CC=C(F)C(=C3)Cl)N=CN=C2C=C1OC4CCOC4

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04206787 Not yet recruiting Drug: Afatinib Non-squamous Non-Small Cell Lung Cancer Boehringer Ingelheim May 6 2020 --
NCT04158947 Recruiting Drug: Afatinib|Drug: T-DM1 HER2-positive Breast Cancer|Brain Metastases xuexin he|Second Affiliated Hospital School of Medicine Zhejiang University May 10 2020 Phase 2
NCT03711422 Not yet recruiting Drug: Afatinib Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03083678 Recruiting Drug: Afatinib Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2
NCT03370770 Completed Drug: Afatinib|Drug: Osimertinib Carcinoma Non-Small-Cell Lung Boehringer Ingelheim December 28 2017 --
NCT02423525 Recruiting Drug: Afatinib Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute December 2016 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID