Afatinib (BIBW2992)

For research use only.

Catalog No.S1011

209 publications

Afatinib (BIBW2992) Chemical Structure

CAS No. 850140-72-6

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.

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Selleck's Afatinib (BIBW2992) has been cited by 209 publications

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M1G0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PxfGlEPTB;MD6wNFU4OiEQvF2= MUjTRW5ITVJ?
KASUMI-1 Ml:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjEZYVKSzVyPUCuNFA6OTFizszN MUHTRW5ITVJ?
HCC2218 NUXZVIR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFuwUZBKSzVyPUCuNFA6QDdizszN NYLsd2x4W0GQR1XS
KARPAS-45 MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HXSGlEPTB;MD6wNVY4OSEQvF2= MlzRV2FPT0WU
HSC-4 NEPCSIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzaTItKSzVyPUCuNFE4PDhizszN M2fiN3NCVkeHUh?=
CHL-1 NFq1d5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofZTWM2OD1yLkCxPFM6KM7:TR?= M1TvNXNCVkeHUh?=
KY821 Mnr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPNeFBxUUN3ME2wMlAzODZizszN NUX3XZlzW0GQR1XS
NCI-N87 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEK3O|Mh|ryP NHv2bGdUSU6JRWK=
DOK M3LhVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq2TWM2OD1yLkCzNVk1KM7:TR?= NIDnRWpUSU6JRWK=
DSH1 MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXFTWM2OD1yLkCzN|E1KM7:TR?= M1\JTXNCVkeHUh?=
MDA-MB-175-VII NFv0eZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEO0NVYh|ryP MYfTRW5ITVJ?
NCI-H2170 NYDZWWhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn6WmU3UUN3ME2wMlA{PzJ6IN88US=> NGizXVdUSU6JRWK=
BT-474 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMES5PFYh|ryP MV7TRW5ITVJ?
EFO-27 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEWxPFIh|ryP MnzyV2FPT0WU
NCI-H720 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rDNWlEPTB;MD6wOVMzPSEQvF2= MY\TRW5ITVJ?
PC-14 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjvZ4NKSzVyPUCuNFU3PjhizszN NX3kTotkW0GQR1XS
EC-GI-10 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\ydop5UUN3ME2wMlA2QTF{IN88US=> NFTpfolUSU6JRWK=
KYSE-450 MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XlUWlEPTB;MD6wOVk4QCEQvF2= MU\TRW5ITVJ?
BPH-1 NYm4OYt2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LGeGlEPTB;MD6wOVk5QCEQvF2= NGfBO4hUSU6JRWK=
NCI-H292 Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfTTWM2OD1yLkC2NFkh|ryP M{flUnNCVkeHUh?=
H9 NVLzbnFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XJZWlEPTB;MD6wO|E{OiEQvF2= NHXOXYxUSU6JRWK=
NCI-H526 M3y0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrXSFRCUUN3ME2wMlA4QDJ|IN88US=> M2W5NXNCVkeHUh?=
NCI-H1623 Mmq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\3T3RKSzVyPUCuNFgxOjVizszN NW\mUopsW0GQR1XS
KYSE-140 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPzTWM2OD1yLkC4N|Mh|ryP MmfUV2FPT0WU
Ca9-22 MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMEizOVMh|ryP NHrlWXRUSU6JRWK=
AU565 MlqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{eyO2lEPTB;MD6wPFUxPCEQvF2= NEHG[G9USU6JRWK=
ZR-75-30 NVnWRmw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwMEm1OFUh|ryP MX3TRW5ITVJ?
NCI-H1770 NHnGSmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMUCyPEDPxE1? MlvOV2FPT0WU
LB2241-RCC NXfqR|NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PLSGlEPTB;MD6xNFg5PCEQvF2= MmLxV2FPT0WU
CAL-39 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13RWmlEPTB;MD6xNVc6OiEQvF2= Mn:xV2FPT0WU
UACC-893 NUnPZXVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV25XWRqUUN3ME2wMlEyQDh3IN88US=> NGLyUHVUSU6JRWK=
LU-65 M1rXe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHraXINKSzVyPUCuNVI3OzNizszN MojGV2FPT0WU
HN NXj3OGZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT5TWM2OD1yLkGzNFc4KM7:TR?= M{D3R3NCVkeHUh?=
TI-73 NWP4VGI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\2WGlEPTB;MD6xOFcyPSEQvF2= MV3TRW5ITVJ?
KU812 MlPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPqTVU4UUN3ME2wMlE2PDV4IN88US=> MoTCV2FPT0WU
SW13 M3npOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf6[VFKSzVyPUCuNVYzOTZizszN M{LYZ3NCVkeHUh?=
BB30-HNC MnTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HiS2lEPTB;MD6xOlU4PiEQvF2= NWnsRYZMW0GQR1XS
HSC-2 MnzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXjNZFKSzVyPUCuNVY5OzdizszN M1:4cXNCVkeHUh?=
BV-173 Mn\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT1UYNKSzVyPUCuNVc2QTZizszN MV\TRW5ITVJ?
CAL-27 NGfPcoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMUe2N|Yh|ryP NEXYSopUSU6JRWK=
SBC-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DmSGlEPTB;MD6xPFk2QSEQvF2= MWDTRW5ITVJ?
CAL-33 NHTib2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nEdWlEPTB;MD6yNFE5PCEQvF2= M3y0Z3NCVkeHUh?=
NCI-H209 NGrseotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j2WWlEPTB;MD6yNFQ3KM7:TR?= MlOyV2FPT0WU
COR-L105 Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMkGwPFQh|ryP MlrGV2FPT0WU
HSC-3 MlPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMkGxPVgh|ryP Mn\nV2FPT0WU
NCI-H69 M{X1W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXCZ|FTUUN3ME2wMlIyPDVzIN88US=> M3rvV3NCVkeHUh?=
MOLT-13 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;OTWM2OD1yLkKzPVc2KM7:TR?= NFz0UZVUSU6JRWK=
ML-2 Ml7NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jqfmlEPTB;MD6yOFgxOiEQvF2= NFjCcWRUSU6JRWK=
IGROV-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTBwMkW5OVIh|ryP NG\QWXJUSU6JRWK=
TK10 NYfEb2MzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXmUo5nUUN3ME2wMlI3PzN6IN88US=> MY\TRW5ITVJ?
EoL-1-cell MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPuTWM2OD1yLkK2PFkzKM7:TR?= NVnJ[nZbW0GQR1XS
HO-1-N-1 NHPkSGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TyT2lEPTB;MD6yO|g2OyEQvF2= M1SwfnNCVkeHUh?=
BHY M4Lyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\ITWM2OD1yLkK4OlU2KM7:TR?= MnW3V2FPT0WU
LU-139 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi1OXJnUUN3ME2wMlMxPTFizszN NIXsR|dUSU6JRWK=
23132-87 NYq1Zox4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrGWoQyUUN3ME2wMlMyQTJ|IN88US=> MVHTRW5ITVJ?
ACHN MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwM{G5PVQh|ryP MmT6V2FPT0WU
DoTc2-4510 NFnCeWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwM{KyNVkh|ryP MoT6V2FPT0WU
BB65-RCC NInDc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXuzbIhGUUN3ME2wMlM1PTl|IN88US=> MYLTRW5ITVJ?
HLE MlOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f5c2lEPTB;MD6zOVA1PiEQvF2= NFHWOHZUSU6JRWK=
HCC1419 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXnTWM2OD1yLkO2OFA5KM7:TR?= MWrTRW5ITVJ?
A388 M3rK[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;sW2lEPTB;MD6zOlg2PyEQvF2= M4\4fnNCVkeHUh?=
NUGC-3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrjWFlKSzVyPUCuN|g{PzNizszN NEn1[2RUSU6JRWK=
KYSE-180 NEn4V3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL4TWM2OD1yLkO5NFg6KM7:TR?= M4jJeHNCVkeHUh?=
TE-6 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwNECyOFYh|ryP MVLTRW5ITVJ?
A498 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVO4WlZlUUN3ME2wMlQxPjd2IN88US=> NUjaNJY3W0GQR1XS
NCI-H1648 Mnm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G3UWlEPTB;MD60OFE5OiEQvF2= M{LaXnNCVkeHUh?=
DU-145 M1HDNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvoc4dwUUN3ME2wMlQ1QDN|IN88US=> MVfTRW5ITVJ?
CW-2 MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PmOGlEPTB;MD60OlkyPCEQvF2= NF3H[4FUSU6JRWK=
A431 M2PWRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwNEiyN|Mh|ryP MUHTRW5ITVJ?
SAS MkPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwNEizPVgh|ryP M2Ls[HNCVkeHUh?=
NCI-H2126 NWDZcHFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwNUG5NlYh|ryP M3vQVXNCVkeHUh?=
NCI-H358 MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIThNotKSzVyPUCuOVMzOSEQvF2= Mnu5V2FPT0WU
FADU MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrRTXRKSzVyPUCuOVQ1ODRizszN NGHIXIRUSU6JRWK=
ACN NXnHb4poT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXLb5ZKSzVyPUCuOVUxQTRizszN NGPzUlBUSU6JRWK=
HCC70 M3nJNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL1c4NpUUN3ME2wMlU4PjZzIN88US=> MWPTRW5ITVJ?
NCI-H1838 MknJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwNkCyPVkh|ryP MoSzV2FPT0WU
CAL-54 NGLDOXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwNkG2NlEh|ryP NGHjbZFUSU6JRWK=
NCI-H1975 NUDyTmx6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\JTWM2OD1yLk[xO|I5KM7:TR?= M{jCWXNCVkeHUh?=
COR-L88 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37KNmlEPTB;MD62OFEyOyEQvF2= NYrteWY6W0GQR1XS
CTV-1 NWrwb5ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTOeXZ5UUN3ME2wMlY1Ozl{IN88US=> NWDve|RSW0GQR1XS
EW-18 NGLIOohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXLTWM2OD1yLk[4Olk5KM7:TR?= MYTTRW5ITVJ?
HCC1806 MlzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXXZYw2UUN3ME2wMlY6PjZ4IN88US=> MmPGV2FPT0WU
HuP-T4 NHfPVY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfBUZpKSzVyPUCuOlk4PiEQvF2= M{fBRXNCVkeHUh?=
MDA-MB-361 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGH0S3VKSzVyPUCuO|I3PjJizszN MVLTRW5ITVJ?
NCI-H1573 NED0[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwN{O2N{DPxE1? MkGxV2FPT0WU
KU-19-19 NV3HNoVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwN{e0OlQh|ryP NVq4XohWW0GQR1XS
COLO-678 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnT1TWM2OD1yLkiwPFM1KM7:TR?= Mn\LV2FPT0WU
C-33-A M3f1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi5XGhKSzVyPUCuPFEzQTdizszN M3zYR3NCVkeHUh?=
Calu-3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTBwOEG0N|Qh|ryP MkH3V2FPT0WU
AGS NG\mWFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrtW21HUUN3ME2wMlg{PjR6IN88US=> MVfTRW5ITVJ?
SCC-25 NHvveIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwOESxO|Eh|ryP NXO5OZh{W0GQR1XS
JVM-2 MoHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnEW41KSzVyPUCuPFgzQTlizszN NWnBclU{W0GQR1XS
HCE-T MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Xt[GlEPTB;MD64PFQzQCEQvF2= NV;wOFViW0GQR1XS
ES4 NHPWOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLnTWM2OD1yLkm3PFM3KM7:TR?= NHrVd4FUSU6JRWK=
EKVX NIHmb3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf2TWM2OD1zLkCxNFY1KM7:TR?= M1fOenNCVkeHUh?=
D-542MG MnXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorWTWM2OD1zLkCxNFY1KM7:TR?= M1L2cHNCVkeHUh?=
SW1116 MnPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzuTWM2OD1zLkCxNlg4KM7:TR?= NF64d3RUSU6JRWK=
5637 NELiWIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLVfmtWUUN3ME2xMlAyPTFizszN M1vxdHNCVkeHUh?=
HT-1376 M2KzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTFwMEG1NVMh|ryP Mn3KV2FPT0WU
NB69 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPLfph4UUN3ME2xMlAzQTR3IN88US=> MWnTRW5ITVJ?
YKG-1 MkDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPhS25KSzVyPUGuNFU1OTlizszN MlvCV2FPT0WU
EW-3 M4\ISWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfGSoFiUUN3ME2xMlA4QDh|IN88US=> MV\TRW5ITVJ?
GCIY NGDUPW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XN[2lEPTB;MT6wPFExPCEQvF2= Ml7uV2FPT0WU
SK-MES-1 NEfBVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTFwMUG0PFch|ryP NXfwZnB1W0GQR1XS
PANC-08-13 M{Tpc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPhTWM2OD1zLkG2OFE3KM7:TR?= NW\k[|dXW0GQR1XS
SK-NEP-1 NWjSOmpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXmwNnFZUUN3ME2xMlE4PTF|IN88US=> Mn3wV2FPT0WU
SW954 NH7hd|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\lO2lEPTB;MT6yNFIyPCEQvF2= NYX4fGpRW0GQR1XS
NCI-SNU-5 NHLRSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PKVGlEPTB;MT6yN|kh|ryP NXTzT3p{W0GQR1XS
SW48 NFPPUVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3POXmlEPTB;MT6yOVQ{OiEQvF2= MV;TRW5ITVJ?
HT-3 NHHuNVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTFwMki3OVMh|ryP MkHaV2FPT0WU
ETK-1 Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7GcYdKSzVyPUGuN|c1PTZizszN M2LpU3NCVkeHUh?=
SCC-15 M4\R[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm5bGFKSzVyPUGuN|k1PTFizszN M3HRXnNCVkeHUh?=
DU-4475 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LxbGlEPTB;MT60NFEzOSEQvF2= M1XUeHNCVkeHUh?=
NB5 NX7kcotmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O2fWlEPTB;MT60NVMyPyEQvF2= MnTzV2FPT0WU
CFPAC-1 NUDlXVQyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;KR2lEPTB;MT60NlQ6OyEQvF2= M4jpTHNCVkeHUh?=
NCI-H630 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3h[FBKSzVyPUGuOFU2QDJizszN NEjKR5hUSU6JRWK=
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D-502MG M1KxR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HES2lEPTB;OD6yPVI5OiEQvF2= NWizcZREW0GQR1XS
NCI-H1993 M2jFOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LzOWlEPTB;OD6zN|Y{OSEQvF2= Mlm3V2FPT0WU
SCC-4 M33Tfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRThwNESwOVkh|ryP NULPTlFzW0GQR1XS
HAL-01 NX7MZotmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn6e4V{UUN3ME24MlUyQTFizszN M3fvc3NCVkeHUh?=
GT3TKB NGT4RmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX4SpRCUUN3ME24MlY4QTZ2IN88US=> NFvTUHJUSU6JRWK=
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COLO-829 NWm3PVR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXCTWM2OD16LkiwPVc3KM7:TR?= NVHlVZFmW0GQR1XS
OCI-AML2 NYDESVRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXIVWs2UUN3ME24Mlk2PDhzIN88US=> NFvkSGJUSU6JRWK=
OS-RC-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXQNohKSzVyPUmuNFIyQSEQvF2= NXPSVWg3W0GQR1XS
BFTC-909 NXLrW2d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3qe|ZKSzVyPUmuNFY4QTlizszN MVjTRW5ITVJ?
EW-11 NXTTcGQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7KTWM2OD17LkG3OlU{KM7:TR?= NH7mWZBUSU6JRWK=
HCE-4 M2\Femdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml65TWM2OD17LkKxOVU5KM7:TR?= M3fpTHNCVkeHUh?=
BALL-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\ZTWM2OD17LkKxPVA4KM7:TR?= NUDHdFkyW0GQR1XS
SF539 M3O4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDW[IFKSzVyPUmuNlM2PjJizszN MlnSV2FPT0WU
CAMA-1 MnTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe3WmltUUN3ME25MlI5OTJ6IN88US=> MmThV2FPT0WU
C32 NX;xdmtTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzVZ5U4UUN3ME25MlM{ODZ2IN88US=> NVLoT5ByW0GQR1XS
NCI-H1703 M4DFdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGT2bnNKSzVyPUmuN|Q{PzVizszN MYnTRW5ITVJ?
NCI-H1650 M4jBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTlwNkC5OFYh|ryP NEWxcGJUSU6JRWK=
NCI-H1563 NV;aT29JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3rTWM2OD17Lke2NFMyKM7:TR?= MWrTRW5ITVJ?
CAL-85-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHkXGNKSzVyPUmuPFc{QDNizszN MW\TRW5ITVJ?
UM-UC-3 M2XaN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn1UYJDUUN3ME25Mlk2ODNizszN M{XudHNCVkeHUh?=
BxPC-3 NFq3foZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTFyLkC5O|Ih|ryP NVfFUJV4W0GQR1XS
MHH-PREB-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nReGlEPTB;MUCuNVk6QSEQvF2= MnHsV2FPT0WU
DEL NHLqT4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2K4ZWlEPTB;MUCuN|k1PiEQvF2= MXHTRW5ITVJ?
HuCCT1 NWHy[oRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\lTWM2OD1zMD62NFM{KM7:TR?= NHfh[4pUSU6JRWK=
OVCAR-4 M3THR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHEOGdlUUN3ME2xNE45QDN3IN88US=> NFv2UXRUSU6JRWK=
CAL-72 NH3DenFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\VTWM2OD1zMD65N|kyKM7:TR?= NF7DRldUSU6JRWK=
HCC1954 NEfyN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXFZpBKSzVyPUGxMlA4PTRizszN MXPTRW5ITVJ?
EFO-21 Ml:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTFzLkGwOFUh|ryP NF7HflVUSU6JRWK=
FTC-133 NHHz[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK0TWM2OD1zMT6xOFA4KM7:TR?= M2rKdnNCVkeHUh?=
SK-MEL-24 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi1TWM2OD1zMT6yN|Y3KM7:TR?= MW\TRW5ITVJ?
UACC-62 NVTrfo9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH5WnBKSzVyPUGxMlI{PjhizszN MXrTRW5ITVJ?
NCI-H650 NVTNSWhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFzLkK0NVgh|ryP NX\5fGZlW0GQR1XS
ALL-PO Ml;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17Dc2lEPTB;MUGuNlUyOiEQvF2= MoewV2FPT0WU
T84 Ml\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHYRlF4UUN3ME2xNU4{QTB5IN88US=> MUHTRW5ITVJ?
IST-MEL1 NFqyRnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILDPGVKSzVyPUGxMlQ2PTlizszN MYDTRW5ITVJ?
SW626 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfYcJRSUUN3ME2xNU42PzV3IN88US=> M37vVnNCVkeHUh?=
RPMI-2650 NVjQRnV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXYTndXUUN3ME2xNU42QDh3IN88US=> NXTKWHF{W0GQR1XS
MC-IXC NVj2TmQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPCWJRKSzVyPUGxMlY4OjhizszN NFTXN4JUSU6JRWK=
HOP-62 MmfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHWTWM2OD1zMT62O|Y1KM7:TR?= MVXTRW5ITVJ?
NOS-1 MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXRPW1KSzVyPUGxMlcyODlizszN NWXxcpk1W0GQR1XS
SW1573 NUW3enIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK3bZNKSzVyPUGxMlczQTVizszN MYPTRW5ITVJ?
WM-115 MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f0OmlEPTB;MUGuO|U5QCEQvF2= NGXxR3VUSU6JRWK=
HuO9 MnPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr0TWM2OD1zMT64O|c1KM7:TR?= NUDDcHptW0GQR1XS
YAPC MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfZTWM2OD1zMT65NlU6KM7:TR?= NI\DbmFUSU6JRWK=
MDA-MB-453 Mni1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13pb2lEPTB;MUGuPVUyPSEQvF2= NHnYU|ZUSU6JRWK=
NCI-H596 NWHscHRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHPSVNKSzVyPUGyMlA{PjlizszN M3;OWnNCVkeHUh?=
A172 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofHTWM2OD1zMj6wO|k5KM7:TR?= MlT4V2FPT0WU
RS4-11 Ml\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofSTWM2OD1zMj6xO|I2KM7:TR?= MnzsV2FPT0WU
HCC1937 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTF{Lke1OlQh|ryP NYXTeW1yW0GQR1XS
SW837 NVzESmNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHwTWM2OD1zMj65NFI5KM7:TR?= MVXTRW5ITVJ?
NMC-G1 MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jCNWlEPTB;MUKuPVI{PCEQvF2= MnnDV2FPT0WU
PFSK-1 M321SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIf0ZplKSzVyPUGzMlA3KM7:TR?= NWjaZmEzW0GQR1XS
DBTRG-05MG NE\kRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF|LkC2N|Ih|ryP MXvTRW5ITVJ?
SK-UT-1 NHzBcWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF|LkGwPFMh|ryP NH\CN5VUSU6JRWK=
OVCAR-5 NFHJdIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTF|LkG1PVMh|ryP NF;MR4VUSU6JRWK=
8505C M3nKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PQfGlEPTB;MUOuNlA3PyEQvF2= Mk\ZV2FPT0WU
SK-MEL-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTF|LkexN|Uh|ryP M3H1WXNCVkeHUh?=
LK-2 MljoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jYS2lEPTB;MUOuO|Y{QSEQvF2= Mk[yV2FPT0WU
OE33 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTF|Lke4OkDPxE1? M4DIUHNCVkeHUh?=
Ramos-2G6-4C10 NIf2[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITPcZVKSzVyPUG0MlAzODJizszN MVXTRW5ITVJ?
EW-13 NHXZV4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX0PWp3UUN3ME2xOE4xOzV{IN88US=> NUX3NnFJW0GQR1XS
NCI-H1793 NUPxfFF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37TfGlEPTB;MUSuNlA5PyEQvF2= MUHTRW5ITVJ?
BHT-101 M2eyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPxTWM2OD1zND6yOFEh|ryP NH\ifHBUSU6JRWK=
RKO MojUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLmeIloUUN3ME2xOE42ODd3IN88US=> M4HFTXNCVkeHUh?=
NEC8 NX;COnhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zjSGlEPTB;MUSuOVQ4OiEQvF2= MYjTRW5ITVJ?
PANC-10-05 M17CRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF2Lk[yOFch|ryP M3LSVHNCVkeHUh?=
NCI-H2030 MkLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zFb2lEPTB;MUSuOlQ1QCEQvF2= NUXZeJBPW0GQR1XS
C2BBe1 NWX2dZl2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPqWI8yUUN3ME2xOE44PjRizszN MlziV2FPT0WU
EM-2 NIrTdWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnv3TWM2OD1zND64OVc3KM7:TR?= M{m5WnNCVkeHUh?=
HCC1395 NUXVenRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrxTWM2OD1zND65N|M5KM7:TR?= NV7aN4VYW0GQR1XS
A2058 NX7DSpBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEWzUWZKSzVyPUG1MlA1ODlizszN MnjHV2FPT0WU
SW1463 MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle2TWM2OD1zNT6wOFg2KM7:TR?= NVLBRVA5W0GQR1XS
J82 NEfIeHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXJXIJrUUN3ME2xOU4xPTdizszN NUX1enE{W0GQR1XS
CAL-120 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljNTWM2OD1zNT6xOFQ4KM7:TR?= MnS5V2FPT0WU
COLO-824 M{DwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTF3LkG1O|kh|ryP MoPxV2FPT0WU
LNCaP-Clone-FGC NUPDbJNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPNNZRsUUN3ME2xOU41OjR6IN88US=> M3j2NnNCVkeHUh?=
CP66-MEL MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfNR3ZLUUN3ME2xOU41Pjh6IN88US=> MkLlV2FPT0WU
OC-314 M37mcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nVUmlEPTB;MUWuOFcyPCEQvF2= NVzRbFBTW0GQR1XS
OVCAR-8 NV3YNI9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTF3Lki4OlEh|ryP M3L4UHNCVkeHUh?=
MFE-280 M4HYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO4c4RKSzVyPUG2MlA1QDhizszN NVu4eWFpW0GQR1XS
MHH-NB-11 MnjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTF4LkC4N|kh|ryP MU\TRW5ITVJ?
SW1990 NUXKdIJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13WN2lEPTB;MU[uNVc2PSEQvF2= MoPBV2FPT0WU
U-266 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTF4LkKyPVkh|ryP NIX0ZYhUSU6JRWK=
MFM-223 NWHRTWZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTF4LkO5OlUh|ryP NFH0ZmFUSU6JRWK=
L-363 Mn3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nST2lEPTB;MU[uOFU4PyEQvF2= NWH0bm5ZW0GQR1XS
MCF7 MlTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37k[WlEPTB;MU[uOFczOyEQvF2= NIPifm1USU6JRWK=
SK-MEL-3 M4TOS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjmd5kyUUN3ME2xOk41Pzh5IN88US=> NFf2XHhUSU6JRWK=
HH MnzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[5VpZjUUN3ME2xOk42OTZ{IN88US=> NHfHU4FUSU6JRWK=
no-10 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTF4Lk[zOFMh|ryP MVjTRW5ITVJ?
HuP-T3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLnTWM2OD1zNj62OVc3KM7:TR?= NF33RXNUSU6JRWK=
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NCI-H1092 M{XTSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTF4LkizNVYh|ryP NUDCPYY3W0GQR1XS
MZ2-MEL M4P5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;uXpVKSzVyPUG2Mlg1ODNizszN MmW5V2FPT0WU
ES3 M1zLNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLtUWxGUUN3ME2xOk46OTN2IN88US=> M4SxR3NCVkeHUh?=
COLO-684 M2XQdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlq4TWM2OD1zNj65OFc4KM7:TR?= MnPlV2FPT0WU
NCI-H661 NH3OSFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PzW2lEPTB;MU[uPVY6PCEQvF2= MnPUV2FPT0WU
CP50-MEL-B NYrzXldqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojETWM2OD1zNz6wN|Q{KM7:TR?= MV3TRW5ITVJ?
NCI-H2405 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;aXGlEPTB;MUeuNVk4PCEQvF2= MWDTRW5ITVJ?
U-2-OS NW\Rdmd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HNNWlEPTB;MUeuOVMxPyEQvF2= MX3TRW5ITVJ?
RERF-LC-MS MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jMRmlEPTB;MUeuOVUxQCEQvF2= NVfWVmh{W0GQR1XS
NCI-H2342 M3PJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HSfmlEPTB;MUeuOVU4KM7:TR?= M{\SSXNCVkeHUh?=
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MOLT-16 MkTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXJdm9KSzVyPUG3Mlg6OzRizszN MoftV2FPT0WU
RH-18 NXPId2pnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3lTWM2OD1zOD6wNFM2KM7:TR?= NHq5SXJUSU6JRWK=
D-283MED MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvHZoluUUN3ME2xPE4xODh6IN88US=> NX;Xb49UW0GQR1XS
RCC10RGB NETqOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\3W|lKSzVyPUG4MlA2PTlizszN NGHwZlNUSU6JRWK=
NCI-H1437 M4jaeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHTTWM2OD1zOD6xOlQyKM7:TR?= NFP0dY1USU6JRWK=
SW982 NE\Zd|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrXdFFPUUN3ME2xPE4zPjdzIN88US=> MXzTRW5ITVJ?
IST-MES1 MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDkTWM2OD1zOD60OFI5KM7:TR?= NE\ZfmdUSU6JRWK=
A704 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\0N2lEPTB;MUiuOFc2OyEQvF2= NGjYWWlUSU6JRWK=
ESS-1 M3HYTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV70ZnlYUUN3ME2xPE42OjB3IN88US=> MmjRV2FPT0WU
SCH MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;KTWM2OD1zOD62OFU3KM7:TR?= M{jCWnNCVkeHUh?=
COLO-320-HSR MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33WSWlEPTB;MUiuO|Q3KM7:TR?= M1j2PXNCVkeHUh?=
Mo-T NYPuZ4lFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i2RWlEPTB;MUiuPFIxPCEQvF2= NGTXXGdUSU6JRWK=
Saos-2 NYLybnVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXLTWM2OD1zOT6xNVYzKM7:TR?= NIPQPW9USU6JRWK=
SW684 NIDVfZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnN[VlZUUN3ME2xPU4yOzJ4IN88US=> MoHWV2FPT0WU
KMOE-2 M3PUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF7LkKyOFIh|ryP M33pR3NCVkeHUh?=
MMAC-SF NXnCdVhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fh[mlEPTB;MUmuNlYxPyEQvF2= NGfiVI1USU6JRWK=
JAR MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\3TWM2OD1zOT6yPVkh|ryP MXLTRW5ITVJ?
SK-MEL-28 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvSNXN7UUN3ME2xPU4{OzZ|IN88US=> NI\DeG5USU6JRWK=
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NOMO-1 M{HYVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi1UW1SUUN3ME2zOE42PzB|IN88US=> NUTxSYZHW0GQR1XS
MZ7-mel MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHiTWM2OD1|ND62OFg4KM7:TR?= NGO1ZmVUSU6JRWK=
NCI-H810 MorYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmr4TWM2OD1|ND63Nlc5KM7:TR?= M3zQOnNCVkeHUh?=
D-392MG Mo\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPycFdPUUN3ME2zOU4xPTZ3IN88US=> MW\TRW5ITVJ?
LB771-HNC MlrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nMeWlEPTB;M{WuNVY2QCEQvF2= Ml;IV2FPT0WU
COLO-679 MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPITWM2OD1|NT6zPFgh|ryP MVzTRW5ITVJ?
SK-PN-DW NVrlb5FlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPI[IkyUUN3ME2zOU41OzZ7IN88US=> M2rqdXNCVkeHUh?=
VA-ES-BJ NWPmR2dHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTEOWNKSzVyPUO1MlQ3PDlizszN NITT[VVUSU6JRWK=
KNS-42 MkjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTN3LkW4NlYh|ryP NE\FNGhUSU6JRWK=
RVH-421 NF\oSG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTN3Lke2OFUh|ryP NXjKOJFxW0GQR1XS
P30-OHK MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrQUnJ3UUN3ME2zOU45PzV{IN88US=> M{TMU3NCVkeHUh?=
G-402 NELsSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDlRYtKSzVyPUO1Mlk5PjdizszN MUTTRW5ITVJ?
S-117 NW\rSJhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXpZ3FXUUN3ME2zOk4{ODB6IN88US=> M1HEWnNCVkeHUh?=
RXF393 NIDhPZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfSWnZvUUN3ME2zOk4{Pzh3IN88US=> MnewV2FPT0WU
LCLC-103H NYXwemVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTN4Lke4NFMh|ryP NYfQTpdNW0GQR1XS
U-118-MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHJenVsUUN3ME2zOk45QDR5IN88US=> MoPyV2FPT0WU
8-MG-BA NWj5cG9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHWzOWlKSzVyPUO2Mlk1QDNizszN MW\TRW5ITVJ?
MFH-ino NUfjUVhTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHFTWM2OD1|Nz6zN|cyKM7:TR?= NEK3SHNUSU6JRWK=
NCI-H23 M1XhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzmTWM2OD1|Nz60NVk3KM7:TR?= M3\zUXNCVkeHUh?=
NCI-H446 NV[zbZl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnmyTWM2OD1|Nz60PFYzKM7:TR?= NIPBfFFUSU6JRWK=
LU-99A M3PvZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HZWWlEPTB;M{euOVc{OSEQvF2= NVHpTWh{W0GQR1XS
KP-N-YN NI[2R|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTN5Lk[xPVUh|ryP NUnRXYx1W0GQR1XS
SCC-9 NInkWJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTN5Lke4N|gh|ryP MlPBV2FPT0WU
EFM-19 NV76NY46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O2VGlEPTB;M{euO|k3PyEQvF2= NInXNlBUSU6JRWK=
A427 NX3hbWJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDvTYhWUUN3ME2zO{46OTB5IN88US=> NEflOFJUSU6JRWK=
LB831-BLC NGPYNZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLHTWM2OD1|OD62NFM6KM7:TR?= NHX2PZBUSU6JRWK=
HOS M4T4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTN7Lk[yO|Mh|ryP MYTTRW5ITVJ?
LAN-6 MnW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnWxTWM2OD12MD6wNVEzKM7:TR?= M3vX[HNCVkeHUh?=
U251 NWj6eIYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzXSFJKSzVyPUSwMlQxPTRizszN M2\zOHNCVkeHUh?=
SNU-387 NX7ucI1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;MZWV{UUN3ME20NE41PTV|IN88US=> MkTxV2FPT0WU
DMS-79 NHvhRVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXe1WWNnUUN3ME20NE42QDh7IN88US=> NWfndm9zW0GQR1XS
SK-LU-1 Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1u4O2lEPTB;NECuOlU3QCEQvF2= MXPTRW5ITVJ?
HT NITxe|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MormTWM2OD12MD62OlM6KM7:TR?= NVXxS3BtW0GQR1XS
KP-N-YS NHLYTGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrDTWM2OD12MD62O|Y5KM7:TR?= MoezV2FPT0WU
DMS-114 NWDNNpFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTRyLkizO|Qh|ryP MlLzV2FPT0WU
HUTU-80 NEj2[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTRzLkC1Olkh|ryP NXj3dWZFW0GQR1XS
ONS-76 NVTmdHAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zvdGlEPTB;NEGuOFcxQSEQvF2= Mkf6V2FPT0WU
A673 M3LUT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnKblFOUUN3ME20NU42OTV5IN88US=> MkDPV2FPT0WU
HPAF-II M3\IVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrlXFZKSzVyPUSxMlY4ODlizszN NF3SOGdUSU6JRWK=
UACC-257 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDrdldpUUN3ME20NU44OzZ7IN88US=> MWXTRW5ITVJ?
EW-22 NV:ySW4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXz[ItKUUN3ME20NU45Pjl5IN88US=> M4O4XHNCVkeHUh?=
NCI-H1755 NVPBNZdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmKwTWM2OD12MT64O|I2KM7:TR?= M12zRnNCVkeHUh?=
KYSE-150 NV\KV3JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG4OVVKSzVyPUSyMlE4QDJizszN MYnTRW5ITVJ?
CGTH-W-1 M3\0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTFToZKSzVyPUSyMlQ6PTVizszN NIrqb45USU6JRWK=
NB13 M4\rSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTR{Lk[yNVch|ryP M3q0c3NCVkeHUh?=
SW872 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD5NXhKSzVyPUSyMlY{OzFizszN M2KyTHNCVkeHUh?=
KP-4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTR{Lki4N|Ih|ryP M1OxV3NCVkeHUh?=
HCC38 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LT[2lEPTB;NEKuPVYyQCEQvF2= M2rXbXNCVkeHUh?=
BB49-HNC MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrPemRKSzVyPUSzMlI{PTZizszN NY\De|JLW0GQR1XS
CAL-62 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\RPHcxUUN3ME20N{41ODJ6IN88US=> MkG1V2FPT0WU
NCI-H2029 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnoTWM2OD12Mz61OVgyKM7:TR?= MkHnV2FPT0WU
M14 NF64cIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XadmlEPTB;NESuNVM{OiEQvF2= Ml;1V2FPT0WU
COLO-680N NVT1d4J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnL6TWM2OD12ND6zN|kh|ryP MVHTRW5ITVJ?
Hs-578-T M3Lpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLNTWM2OD12NT6wNlk1KM7:TR?= MUfTRW5ITVJ?
MSTO-211H NIDUW4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTJTWM2OD12NT65OFgzKM7:TR?= NGDRNJpUSU6JRWK=
EW-1 M3:5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTR3Lkm2PFkh|ryP NFHIUXFUSU6JRWK=
SW948 MljBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTR4LkS0OlIh|ryP NXyxdotqW0GQR1XS
NCI-H460 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\2TWM2OD12Nj61NlMh|ryP M3HuW3NCVkeHUh?=
CAS-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTkTWM2OD12Nj63O|AyKM7:TR?= NHLHOJlUSU6JRWK=
TGBC11TKB NEftOVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTR5LkG3O|ch|ryP NHH4VHFUSU6JRWK=
HD-MY-Z MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTR6Lke4OkDPxE1? NFTNcG9USU6JRWK=
NCI-H226 NIDMUG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPTcmRKSzVyPUS5Mlc4QDVizszN MUjTRW5ITVJ?
PA-1 Mon1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDqfJZKSzVyPUS5Mlg{OzVizszN NVjrRVdZW0GQR1XS
LB2518-MEL NH;yfY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTR7Lki3NlMh|ryP M4PXb3NCVkeHUh?=
A101D MoPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYH0fnhGUUN3ME20PU46PDJ3IN88US=> M4npdnNCVkeHUh?=
NCI-H2087 NXTXcIN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvpTWM2OD12OT65OlgzKM7:TR?= NU\CRoFIW0GQR1XS

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

p-VEGFR2 / VEGFR2 / JAG1 / DLL4 / NICD1 ; 

PubMed: 28533486     


HUVECs were cultured in the presence of Vatalanib (100 nM) or DBZ (10 nM) for 1 h and then treated for 15 min with rhgal-3 (37 nM) and cultured for additional 6 hrs. After this period, the total protein was isolated and the protein levels of galectin-3, NICD1, DLL4, JAG1, VEGFR2 and VEGFR2-p were assessed by Western blot. β-actin was used as a loading control.

25537503 26052929 28533486
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

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In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

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  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Athymic NMRI-nu/nu female mice
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Water Insoluble
Ethanol ''15 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 850140-72-6
Storage powder
in solvent
Synonyms N/A
Smiles CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04497584 Not yet recruiting Drug: Afatinib + Prednisone Advanced Squamous Non Small Cell Lung Cancer University of Texas Southwestern Medical Center September 1 2020 Phase 2
NCT04413201 Not yet recruiting Drug: Afatinib|Drug: Osimertinib Non-squamous NSCLC Michael Hopp|Boehringer Ingelheim|Johannes Gutenberg University Mainz June 30 2020 Phase 4
NCT04206787 Recruiting Drug: Afatinib Non-squamous Non-Small Cell Lung Cancer Boehringer Ingelheim May 20 2020 --
NCT04158947 Recruiting Drug: Afatinib|Drug: T-DM1 HER2-positive Breast Cancer|Brain Metastases xuexin he|Second Affiliated Hospital School of Medicine Zhejiang University May 10 2020 Phase 2
NCT03711422 Not yet recruiting Drug: Afatinib Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03083678 Recruiting Drug: Afatinib Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID