Afatinib (BIBW2992)

For research use only. Not for use in humans.

Catalog No.S1011

180 publications

Afatinib (BIBW2992) Chemical Structure

Molecular Weight(MW): 485.94

Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 570 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Afatinib (BIBW2992) has been cited by 180 publications

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively.
Targets
EGFR (L858R) [1]
(Cell-free assay)
EGFR (wt) [1]
(Cell-free assay)
ErbB4 [2]
(Cell-free assay)
EGFR (L858R/T790M) [1]
(Cell-free assay)
HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 1 nM 10 nM 14 nM
In vitro

BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HDLM-2 M{XuU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHu2SmZKSzVyPUCuNFA2PzJizszN MUHTRW5ITVJ?
KASUMI-1 NGnFfXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHvTWM2OD1yLkCwPVEyKM7:TR?= NXTMcY9FW0GQR1XS
HCC2218 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LJcmlEPTB;MD6wNFk5PyEQvF2= MVvTRW5ITVJ?
KARPAS-45 NX;vUHlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fmRmlEPTB;MD6wNVY4OSEQvF2= MX3TRW5ITVJ?
HSC-4 NXHSTplVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T2eGlEPTB;MD6wNVc1QCEQvF2= NXvh[WduW0GQR1XS
CHL-1 MoXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzSboRIUUN3ME2wMlAyQDN7IN88US=> M{LHcHNCVkeHUh?=
KY821 NYPOcpRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\MZWlEPTB;MD6wNlA3KM7:TR?= NFu0NHJUSU6JRWK=
NCI-N87 NXLrbHJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEK3O|Mh|ryP M4LpZXNCVkeHUh?=
DOK MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\yZmlEPTB;MD6wN|E6PCEQvF2= NVf6e2NYW0GQR1XS
DSH1 NYTJRYlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:3NFVKSzVyPUCuNFM{OTRizszN M1nrN3NCVkeHUh?=
MDA-MB-175-VII MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe2SINKSzVyPUCuNFM1OTZizszN MlXBV2FPT0WU
NCI-H2170 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\LTWM2OD1yLkCzO|I5KM7:TR?= NHu3e5BUSU6JRWK=
BT-474 NGrUWXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVP2VVhWUUN3ME2wMlA1QTh4IN88US=> NVPZRm9XW0GQR1XS
EFO-27 NWDMbJlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEWxPFIh|ryP NVH4VVdyW0GQR1XS
NCI-H720 NXHYbZV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrON3hGUUN3ME2wMlA2OzJ3IN88US=> NGjmR2NUSU6JRWK=
PC-14 M4DZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NISxU3ZKSzVyPUCuNFU3PjhizszN NIPZRZhUSU6JRWK=
EC-GI-10 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm0bZQ3UUN3ME2wMlA2QTF{IN88US=> M1vVZXNCVkeHUh?=
KYSE-450 MlLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEW5O|gh|ryP NVu4WGtnW0GQR1XS
BPH-1 MkDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;HfGlEPTB;MD6wOVk5QCEQvF2= NHTQVpBUSU6JRWK=
NCI-H292 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELUbW9KSzVyPUCuNFYxQSEQvF2= NEHydppUSU6JRWK=
H9 NIj5OnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETBW21KSzVyPUCuNFcyOzJizszN NWHxfZhDW0GQR1XS
NCI-H526 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnu1TWM2OD1yLkC3PFI{KM7:TR?= NEfOZodUSU6JRWK=
NCI-H1623 M{jzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnMdo9CUUN3ME2wMlA5ODJ3IN88US=> MY\TRW5ITVJ?
KYSE-140 NUTlPYg4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfnTWM2OD1yLkC4N|Mh|ryP NH71NI5USU6JRWK=
Ca9-22 M{S5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMEizOVMh|ryP MoPlV2FPT0WU
AU565 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEi1NFQh|ryP NVHHXlg2W0GQR1XS
ZR-75-30 M3;DTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfYTWM2OD1yLkC5OVQ2KM7:TR?= NILRbFNUSU6JRWK=
NCI-H1770 NVe5[2JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMUCyPEDPxE1? M2ixTXNCVkeHUh?=
LB2241-RCC NVLqcI9rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7jeGtKSzVyPUCuNVA5QDRizszN NWDKVXlEW0GQR1XS
CAL-39 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NViwXYZSUUN3ME2wMlEyPzl{IN88US=> NHvkRldUSU6JRWK=
UACC-893 M2riTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnVTWM2OD1yLkGxPFg2KM7:TR?= NGDobVNUSU6JRWK=
LU-65 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3RTIs1UUN3ME2wMlEzPjN|IN88US=> MY\TRW5ITVJ?
HN NFLIXGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XkeWlEPTB;MD6xN|A4PyEQvF2= MVjTRW5ITVJ?
TI-73 NW\2XIhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDOXIJ[UUN3ME2wMlE1PzF3IN88US=> NEnqRm5USU6JRWK=
KU812 M2r1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jzTmlEPTB;MD6xOVQ2PiEQvF2= NHLGSGtUSU6JRWK=
SW13 NHHmfFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD4TWM2OD1yLkG2NlE3KM7:TR?= Ml;xV2FPT0WU
BB30-HNC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMU[1O|Yh|ryP M4fOWXNCVkeHUh?=
HSC-2 NHizOohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HxcWlEPTB;MD6xOlg{PyEQvF2= NGPCOpVUSU6JRWK=
BV-173 MnXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3viOGlEPTB;MD6xO|U6PiEQvF2= NEjRZYZUSU6JRWK=
CAL-27 MmCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zafGlEPTB;MD6xO|Y{PiEQvF2= MoS0V2FPT0WU
SBC-1 MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LtXGlEPTB;MD6xPFk2QSEQvF2= NWPOUYtFW0GQR1XS
CAL-33 MmXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlWzTWM2OD1yLkKwNVg1KM7:TR?= MYfTRW5ITVJ?
NCI-H209 NHXGVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHnTWM2OD1yLkKwOFYh|ryP NHLKTlhUSU6JRWK=
COR-L105 M2fhZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkT5TWM2OD1yLkKxNFg1KM7:TR?= NWXmOoh{W0GQR1XS
HSC-3 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMkGxPVgh|ryP M2LhfXNCVkeHUh?=
NCI-H69 Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W3b2lEPTB;MD6yNVQ2OSEQvF2= M{HMUHNCVkeHUh?=
MOLT-13 MlnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\hTWM2OD1yLkKzPVc2KM7:TR?= NUjFN25GW0GQR1XS
ML-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\ZTWM2OD1yLkK0PFAzKM7:TR?= M{HNenNCVkeHUh?=
IGROV-1 MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjDTWM2OD1yLkK1PVUzKM7:TR?= MmXGV2FPT0WU
TK10 M4L3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnmcJRKSzVyPUCuNlY4OzhizszN M4LJPHNCVkeHUh?=
EoL-1-cell NGPueYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Tze2lEPTB;MD6yOlg6OiEQvF2= MmGxV2FPT0WU
HO-1-N-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMke4OVMh|ryP NIDudGhUSU6JRWK=
BHY MnzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjQcYZKSzVyPUCuNlg3PTVizszN NGPVe4ZUSU6JRWK=
LU-139 NWTpVVBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPh[ZdKSzVyPUCuN|A2OSEQvF2= NWrWUldRW0GQR1XS
23132-87 NELQW|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7tTWM2OD1yLkOxPVI{KM7:TR?= NGHpe5RUSU6JRWK=
ACHN NELNUHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwM{G5PVQh|ryP Ml;PV2FPT0WU
DoTc2-4510 NFjiOo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknRTWM2OD1yLkOyNlE6KM7:TR?= M2PuVXNCVkeHUh?=
BB65-RCC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwM{S1PVMh|ryP MV\TRW5ITVJ?
HLE NX[xO4dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjrTWM2OD1yLkO1NFQ3KM7:TR?= MVrTRW5ITVJ?
HCC1419 MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTBwM{[0NFgh|ryP NVHtZ3Z2W0GQR1XS
A388 MmC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDOdohtUUN3ME2wMlM3QDV5IN88US=> MUHTRW5ITVJ?
NUGC-3 NVL1VZBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TQ[2lEPTB;MD6zPFM4OyEQvF2= NVf2VI1jW0GQR1XS
KYSE-180 NX;WepNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTBwM{mwPFkh|ryP M1jYXHNCVkeHUh?=
TE-6 NGHicJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm2fI1RUUN3ME2wMlQxOjR4IN88US=> MVfTRW5ITVJ?
A498 M1vjXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nDcGlEPTB;MD60NFY4PCEQvF2= NUX5dYZEW0GQR1XS
NCI-H1648 NWLJVJZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmSxTWM2OD1yLkS0NVgzKM7:TR?= MkC3V2FPT0WU
DU-145 NHLCT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwNES4N|Mh|ryP MWHTRW5ITVJ?
CW-2 MmHxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmW0TWM2OD1yLkS2PVE1KM7:TR?= NIPFZnFUSU6JRWK=
A431 Mkf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml2yTWM2OD1yLkS4NlM{KM7:TR?= MnfkV2FPT0WU
SAS Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwNEizPVgh|ryP NWnOPXh3W0GQR1XS
NCI-H2126 NWTRbFJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjBRWdKSzVyPUCuOVE6OjZizszN NGfUZYVUSU6JRWK=
NCI-H358 M{P2WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIX5dItKSzVyPUCuOVMzOSEQvF2= NWfMWmF7W0GQR1XS
FADU NYe2XJp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUO5WJZEUUN3ME2wMlU1PDB2IN88US=> NIG1Z2FUSU6JRWK=
ACN MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwNUWwPVQh|ryP MmXEV2FPT0WU
HCC70 M4DG[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPJR|VoUUN3ME2wMlU4PjZzIN88US=> M17wfHNCVkeHUh?=
NCI-H1838 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Ttc2lEPTB;MD62NFI6QSEQvF2= NHnBXHpUSU6JRWK=
CAL-54 MlXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwNkG2NlEh|ryP NI\SZYxUSU6JRWK=
NCI-H1975 NXTuZmxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwNkG3Nlgh|ryP MofkV2FPT0WU
COR-L88 Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwNkSxNVMh|ryP M3rsU3NCVkeHUh?=
CTV-1 M4foN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYThc4R2UUN3ME2wMlY1Ozl{IN88US=> MXXTRW5ITVJ?
EW-18 MlGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwNki2PVgh|ryP Mnz5V2FPT0WU
HCC1806 MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwNkm2OlYh|ryP NH24bplUSU6JRWK=
HuP-T4 NY\afoVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXBO45KSzVyPUCuOlk4PiEQvF2= MoLSV2FPT0WU
MDA-MB-361 NHHOOGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfNclJ[UUN3ME2wMlczPjZ{IN88US=> NYLkelM3W0GQR1XS
NCI-H1573 NFP2R|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzaTWM2OD1yLkezOlMh|ryP M2nsR3NCVkeHUh?=
KU-19-19 NInueopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwN{e0OlQh|ryP NY\DO5pRW0GQR1XS
COLO-678 NG\B[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rNXGlEPTB;MD64NFg{PCEQvF2= M4n1OnNCVkeHUh?=
C-33-A MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwOEGyPVch|ryP NVvMcGViW0GQR1XS
Calu-3 NHnBbY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT5TWM2OD1yLkixOFM1KM7:TR?= Mle2V2FPT0WU
AGS NEDkU|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon3TWM2OD1yLkizOlQ5KM7:TR?= NV22VpEyW0GQR1XS
SCC-25 NYrPdG9KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[3TWM2OD1yLki0NVcyKM7:TR?= MXLTRW5ITVJ?
JVM-2 Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\ZRYxjUUN3ME2wMlg5Ojl7IN88US=> NGT3fY5USU6JRWK=
HCE-T MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwOEi0Nlgh|ryP NYnu[mxIW0GQR1XS
ES4 M2\YVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnaTWM2OD1yLkm3PFM3KM7:TR?= NF;WO4FUSU6JRWK=
EKVX NF3uNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vVXWlEPTB;MT6wNVA3PCEQvF2= NF\ke2JUSU6JRWK=
D-542MG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr1S4pKSzVyPUGuNFExPjRizszN NHTpTW9USU6JRWK=
SW1116 NWewWIl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[2TWM2OD1zLkCxNlg4KM7:TR?= M4XyZ3NCVkeHUh?=
5637 NITIb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PBTWlEPTB;MT6wNVUyKM7:TR?= MYfTRW5ITVJ?
HT-1376 M2PqOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETy[INKSzVyPUGuNFE2OTNizszN M4P2RXNCVkeHUh?=
NB69 NEnEbGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjpV4JuUUN3ME2xMlAzQTR3IN88US=> NYHlVJVIW0GQR1XS
YKG-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn2PIJGUUN3ME2xMlA2PDF7IN88US=> NVe5RndxW0GQR1XS
EW-3 NIXremFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTFwMEe4PFMh|ryP NHPId3JUSU6JRWK=
GCIY MoDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTFwMEixNFQh|ryP NH;ic|JUSU6JRWK=
SK-MES-1 NHP5SWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DzV2lEPTB;MT6xNVQ5PyEQvF2= NWK5SmlbW0GQR1XS
PANC-08-13 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTkPXNKSzVyPUGuNVY1OTZizszN NVnXe|lqW0GQR1XS
SK-NEP-1 MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Tjb2lEPTB;MT6xO|UyOyEQvF2= NWXLT3p1W0GQR1XS
SW954 Mnn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFezfGtKSzVyPUGuNlAzOTRizszN NUTVXohVW0GQR1XS
NCI-SNU-5 NFHab4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvFTWM2OD1zLkKzPUDPxE1? NUjOcYliW0GQR1XS
SW48 M2rIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW0WopOUUN3ME2xMlI2PDN{IN88US=> Mlr4V2FPT0WU
HT-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\WTWM2OD1zLkK4O|U{KM7:TR?= NYD0PIxNW0GQR1XS
ETK-1 MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnRS2VEUUN3ME2xMlM4PDV4IN88US=> NH3TcmRUSU6JRWK=
SCC-15 MoToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlm4TWM2OD1zLkO5OFUyKM7:TR?= MVHTRW5ITVJ?
DU-4475 NISxdopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfkXWJkUUN3ME2xMlQxOTJzIN88US=> NIDqSZJUSU6JRWK=
NB5 NV[5fIdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXpTWM2OD1zLkSxN|E4KM7:TR?= MUXTRW5ITVJ?
CFPAC-1 NY\lV4lGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTFwNEK0PVMh|ryP MmnHV2FPT0WU
NCI-H630 NYX6endxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDTTWM2OD1zLkS1OVgzKM7:TR?= MkjpV2FPT0WU
NCI-H82 M3XCRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3OeXVKSzVyPUGuOVQxODZizszN Mo\GV2FPT0WU
ECC10 M4\4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDPVnZKSzVyPUGuOVU{PjlizszN M336fHNCVkeHUh?=
K5 M3XnTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrYN4sxUUN3ME2xMlU5OzV5IN88US=> M1j1OHNCVkeHUh?=
ME-180 NIPaeG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjMclNKSzVyPUGuOlExQTZizszN MVPTRW5ITVJ?
KYSE-410 NWHWVmd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFwNkW2O|Ih|ryP M3rJRnNCVkeHUh?=
G-401 M{LFfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\hTWM2OD1zLk[3OFE{KM7:TR?= MXjTRW5ITVJ?
TGBC24TKB MnixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4CxWWlEPTB;MT62PFI{KM7:TR?= NXHvTlNzW0GQR1XS
Detroit562 NEHXOVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PkfGlEPTB;MT63NFE2OiEQvF2= NV3iPWptW0GQR1XS
OE19 M{PxeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTFwN{G1NVIh|ryP NHPIN4VUSU6JRWK=
CAKI-1 NHTUVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPWTWM2OD1zLke4NlEyKM7:TR?= MV7TRW5ITVJ?
TE-12 NEmzOFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrnR|lrUUN3ME2xMlgxPDF2IN88US=> MXvTRW5ITVJ?
NCI-H1666 NXPpdXpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLZTWM2OD1zLkiwPVQ5KM7:TR?= M1LOd3NCVkeHUh?=
TE-1 NEnHV|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7FTWM2OD1zLkixOFc2KM7:TR?= MYTTRW5ITVJ?
CAL-12T MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTFwOEi5OFUh|ryP M1rkdXNCVkeHUh?=
TE-8 NXrWcYtET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33w[2lEPTB;MT65NVM4PyEQvF2= MnjyV2FPT0WU
KYSE-270 NVm4fWt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTJwMEK3N|Ih|ryP MXLTRW5ITVJ?
GMS-10 NEP0Z5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TKSWlEPTB;Mj6wN|UyPyEQvF2= M3X1THNCVkeHUh?=
A2780 M{DtZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmi3TWM2OD1{LkC2Nlk1KM7:TR?= M2HSfnNCVkeHUh?=
OMC-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJwMEixOlkh|ryP M3nOZnNCVkeHUh?=
LoVo NHSzS4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:xbmlEPTB;Mj6xNFc6PyEQvF2= NVTEcGl4W0GQR1XS
PANC-03-27 Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXTTWM2OD1{LkG2OlMyKM7:TR?= NGXnfHhUSU6JRWK=
MDA-MB-157 NIX3dZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn31TWM2OD1{LkKxPFI5KM7:TR?= NI\0e3ZUSU6JRWK=
CaR-1 MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TuOGlEPTB;Mj6yPFI5OSEQvF2= Mk\EV2FPT0WU
769-P MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\KWGlEPTB;Mj6yPVA{PyEQvF2= NH7x[4FUSU6JRWK=
NB7 NGHN[29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXpOIpKSzVyPUKuNlk3PzZizszN MULTRW5ITVJ?
MKN7 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJwM{WzN|Uh|ryP MVjTRW5ITVJ?
NCI-H1048 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOyTWM2OD1{LkS5NVU5KM7:TR?= MX7TRW5ITVJ?
RCM-1 M3G3dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTJwNUK5N|gh|ryP NHX3fJhUSU6JRWK=
HT55 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH4V4l6UUN3ME2yMlU4OzhizszN NFuzRoZUSU6JRWK=
HCC1569 M3zNUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1e0Z2lEPTB;Mj61PFI6PyEQvF2= M4PTfXNCVkeHUh?=
LXF-289 MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr0TWM2OD1{Lk[zOVY2KM7:TR?= NGC1epBUSU6JRWK=
OVCAR-3 M2TLTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHrS4VKSzVyPUKuOlcyPjdizszN Mnz0V2FPT0WU
TE-10 NFy4OpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJwNkiwO|gh|ryP NV7X[WM5W0GQR1XS
SNU-C2B NYXjVWoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\oOWlEPTB;Mj62PFYyPiEQvF2= MlznV2FPT0WU
LB1047-RCC NFHYVmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\tTWM2OD1{Lke0PFg5KM7:TR?= NEey[YxUSU6JRWK=
SN12C M1T4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\2N29kUUN3ME2yMlkyQTZ2IN88US=> MmPvV2FPT0WU
786-0 NWjpT5lsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDTPXRKSzVyPUOuNFY1ODhizszN MX\TRW5ITVJ?
HT-29 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzvU2hMUUN3ME2zMlA4OzB7IN88US=> NGjwZ4FUSU6JRWK=
RPMI-7951 M{nUcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTNwMEe1PUDPxE1? MUHTRW5ITVJ?
NBsusSR MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTNwMUiyOVQh|ryP MWDTRW5ITVJ?
NKM-1 M{Lz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTNwMUi3OFQh|ryP NVzrcINIW0GQR1XS
Capan-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnXNmJoUUN3ME2zMlQ3QDd3IN88US=> NFzzfo9USU6JRWK=
MKN1 M3zwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXEWogxUUN3ME2zMlQ4OTB6IN88US=> NFfMV4lUSU6JRWK=
OAW-42 NI\lT5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIKxfWdKSzVyPUOuOVAxOjZizszN MXPTRW5ITVJ?
SKG-IIIa MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFqzZXdKSzVyPUOuOVIzOzdizszN MkTmV2FPT0WU
no-11 MkDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnIUGZtUUN3ME2zMlU{PTZ2IN88US=> MYTTRW5ITVJ?
NY M1rlVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXYTWM2OD1|LkWzOlU2KM7:TR?= NHfCWXlUSU6JRWK=
HEC-1 NX;rS4M1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXJO5ZlUUN3ME2zMlU5QTVizszN NFLwV2dUSU6JRWK=
NCI-H441 M1vYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mom5TWM2OD1|LkW5PFQyKM7:TR?= NHf1S3BUSU6JRWK=
NCI-H2009 NHLleYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrlTWM2OD1|Lk[xNlE3KM7:TR?= MYXTRW5ITVJ?
T47D MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTNwNkKyNVch|ryP MoXFV2FPT0WU
SNU-449 NWj2RnloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HzUGlEPTB;Mz62OVgzPiEQvF2= MXPTRW5ITVJ?
NCI-SNU-1 MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTNwNkm3N|Uh|ryP M2jteXNCVkeHUh?=
BT-20 M3\Ve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTNwNkm3PVUh|ryP MYHTRW5ITVJ?
LS-123 NVjJbmRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P2ZmlEPTB;Mz63OFI5PCEQvF2= NYG4RYpQW0GQR1XS
8305C NXPBenVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzUTnpKSzVyPUOuO|U6OTFizszN M1ntZnNCVkeHUh?=
OCUB-M M3v5[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTNwN{[xPFch|ryP NIDHd|lUSU6JRWK=
KOSC-2 NFvFTGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XJc2lEPTB;Mz64N|Q2OSEQvF2= M{WzPXNCVkeHUh?=
NCI-H1693 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDjZ3JKSzVyPUOuPFQyQDFizszN NWXJUYhlW0GQR1XS
TE-9 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoW0TWM2OD1|Lki0N|gzKM7:TR?= MUPTRW5ITVJ?
MV-4-11 M2C2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvOTWM2OD1|Lki3PVk1KM7:TR?= MWLTRW5ITVJ?
GAMG NGPRSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT4TWM2OD1|LkmxN|E1KM7:TR?= MWHTRW5ITVJ?
KNS-62 M33heGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf0cZhKSzVyPUOuPVQ4OzFizszN Mnm1V2FPT0WU
MC116 MmnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\vcpVKSzVyPUOuPVU1QDlizszN NV;iOZV2W0GQR1XS
647-V NH65dlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfsTWM2OD1|Lkm4OFUzKM7:TR?= MULTRW5ITVJ?
U-87-MG MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEGzT4hKSzVyPUSuNVA1QDFizszN NETpVZJUSU6JRWK=
RPMI-8226 MmjCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TP[WlEPTB;ND6xNVY{OSEQvF2= NYPrWoNqW0GQR1XS
SW1417 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLnWWZuUUN3ME20MlEzOTR5IN88US=> NYjxN5dqW0GQR1XS
LAMA-84 M3\6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPvPFljUUN3ME20MlE4ODJizszN MnH3V2FPT0WU
LS-513 M1rtSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLVTWM2OD12LkOxNlE4KM7:TR?= NF3HVHlUSU6JRWK=
KLE MlrPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\QZ25KSzVyPUSuOFA5OTlizszN NV;BTYJzW0GQR1XS
HCT-116 NEH1XWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTRwNEGwNFch|ryP NXzkOVdKW0GQR1XS
EPLC-272H MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\5O5hSUUN3ME20MlQyPTN|IN88US=> NHv2RmNUSU6JRWK=
KS-1 NVyz[ldnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LVXGlEPTB;ND61NFg5QSEQvF2= MnjTV2FPT0WU
HT-1197 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHqNndjUUN3ME20MlUzPjZ7IN88US=> NGG2fm1USU6JRWK=
LCLC-97TM1 M3WzVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3ueohnUUN3ME20MlU{Pjh4IN88US=> MV3TRW5ITVJ?
ES5 Mke3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTRwOEO3NlMh|ryP MXjTRW5ITVJ?
CTB-1 NF\JTJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFe2PG9KSzVyPUSuPFQ5QCEQvF2= NHe2ZVlUSU6JRWK=
HL-60 NWjHclc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEG3TmJKSzVyPUSuPFY3OTFizszN NXywNZZCW0GQR1XS
VM-CUB-1 M2DmNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXCZ|JjUUN3ME20Mlg3QDF7IN88US=> NEXIXYRUSU6JRWK=
MEG-01 Mn7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17JVmlEPTB;ND65PVQxOyEQvF2= M4KwZnNCVkeHUh?=
KYSE-520 NVzGcJhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrZdY9KUUN3ME21MlIxQDN7IN88US=> MlHMV2FPT0WU
HuO-3N1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vXcGlEPTB;NT6yOFA1OyEQvF2= NUDnZ|c3W0GQR1XS
SW620 M2fpOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX60PHl6UUN3ME21MlI1QTZ2IN88US=> MnLxV2FPT0WU
U031 NGTZXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Dx[mlEPTB;NT6yOVQzPCEQvF2= NF[0S2RUSU6JRWK=
TE-5 M33j[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTVwNEC4OUDPxE1? NE\6NmZUSU6JRWK=
NCI-H747 M13Rcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;sTWM2OD13LkSyOFczKM7:TR?= NUC1clFIW0GQR1XS
MG-63 MnHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TqbmlEPTB;NT60PFc3OiEQvF2= MYfTRW5ITVJ?
HC-1 NWrSTHNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTVwNUG4N|kh|ryP M3\0THNCVkeHUh?=
HCC2998 NHrrPYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnThTWM2OD13LkWyOlE2KM7:TR?= MkXmV2FPT0WU
NTERA-S-cl-D1 NV3kV4M5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{Oxb2lEPTB;NT61OFU{PyEQvF2= M2rlPXNCVkeHUh?=
KINGS-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLjXpRKSzVyPUWuOlA6PDRizszN NX;YdohQW0GQR1XS
D-423MG NFqzXG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\0U2lEPTB;NT62NVcxPSEQvF2= M{X4W3NCVkeHUh?=
SW962 MoPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHS5eHBKSzVyPUWuOlIxOzJizszN MoDZV2FPT0WU
LOXIMVI MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW2dW9HUUN3ME21MlY{QDd|IN88US=> MWLTRW5ITVJ?
LS-411N M17GfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[xTWM2OD13Lke5OFQyKM7:TR?= NV;DO3dSW0GQR1XS
NCI-H2291 NF\wWXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnK[YRKSzVyPUWuPVg6PDNizszN MnuwV2FPT0WU
A549 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTZwMUK1OVMh|ryP NGrpeZVUSU6JRWK=
LS-1034 NHHxXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjt[WJKSzVyPU[uNlA4ODZizszN M2HCbXNCVkeHUh?=
NB14 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXifJFKSzVyPU[uOFM5OzZizszN MmnPV2FPT0WU
NCI-H1299 M1i3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmwSIZKSzVyPU[uOlMyPzFizszN MkfaV2FPT0WU
BT-549 NVjRSZhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfaS5JsUUN3ME22MlY3QDh7IN88US=> NXi4V2xyW0GQR1XS
J-RT3-T3-5 M2DpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTZwOE[5JO69VQ>? MoHQV2FPT0WU
SW756 NV\SWHhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTZwOUGxO|Yh|ryP NGPvNHlUSU6JRWK=
DJM-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKzTWM2OD14LkmyNFEzKM7:TR?= MnLBV2FPT0WU
GP5d MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTrTWM2OD14Lkm3N|k1KM7:TR?= NGfGR4FUSU6JRWK=
MOLT-4 NV7DOFVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rrVmlEPTB;Nz6wNlE{PSEQvF2= M3jrfnNCVkeHUh?=
NCI-H28 NFzicmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHjdnVKSzVyPUeuNVY1ODVizszN M3fXTnNCVkeHUh?=
MN-60 M1XjdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTdwMkiwPFkh|ryP M1rVOXNCVkeHUh?=
RMG-I NGj5dZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TFeGlEPTB;Nz6zPVI6PiEQvF2= NVnMOlkzW0GQR1XS
COLO-800 NHT5TXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTdwNEG0OFYh|ryP MU\TRW5ITVJ?
DB NI[2XWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7MTWM2OD15Lk[xNFA2KM7:TR?= M2H4WnNCVkeHUh?=
Ca-Ski MnvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrSTWttUUN3ME23MlY1OjV7IN88US=> M1nEOnNCVkeHUh?=
HEL M3rLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX6OoVKSzVyPUeuO|EzODNizszN MoP3V2FPT0WU
NH-12 NVKwdXVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXSZVBwUUN3ME23MlczQDB6IN88US=> NWXFO3piW0GQR1XS
LB373-MEL-D MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;mTWM2OD15Lke2O|cyKM7:TR?= MXvTRW5ITVJ?
SW900 MonLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnRS4VKSzVyPUeuPFIyOjFizszN M{LUcnNCVkeHUh?=
JVM-3 NHzqfVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;COYxTUUN3ME23Mlg6PTl7IN88US=> NVjLZYlkW0GQR1XS
OAW-28 NIXUTG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLxcXpKSzVyPUeuPVQ2PzhizszN MljyV2FPT0WU
KURAMOCHI NHPFS5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jTWmlEPTB;Nz65OFgyOSEQvF2= MXrTRW5ITVJ?
BE-13 NUfkeZFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXvTINoUUN3ME23Mlk5OTF{IN88US=> Ml;FV2FPT0WU
VMRC-RCZ NH61WmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRThwMEG2PVch|ryP MYHTRW5ITVJ?
NCI-H727 M3KwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET4eY5KSzVyPUiuNVA1OiEQvF2= NWnYfphxW0GQR1XS
SW1710 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DXSmlEPTB;OD6xPFUyPSEQvF2= MorxV2FPT0WU
D-502MG MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fqN2lEPTB;OD6yPVI5OiEQvF2= MXrTRW5ITVJ?
NCI-H1993 MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLsTWM2OD16LkOzOlMyKM7:TR?= MV7TRW5ITVJ?
SCC-4 Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorhTWM2OD16LkS0NFU6KM7:TR?= MWfTRW5ITVJ?
HAL-01 NHHyb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mln6TWM2OD16LkWxPVEh|ryP MkT1V2FPT0WU
GT3TKB NXLVVW92T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LuZWlEPTB;OD62O|k3PCEQvF2= M{TIenNCVkeHUh?=
SK-OV-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHiV21KSzVyPUiuO|E{OjlizszN MWTTRW5ITVJ?
COLO-829 NI\zVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fwS2lEPTB;OD64NFk4PiEQvF2= NHzT[FhUSU6JRWK=
OCI-AML2 NVK0[YE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnYTWM2OD16Lkm1OFgyKM7:TR?= M37vU3NCVkeHUh?=
OS-RC-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jrTGlEPTB;OT6wNlE6KM7:TR?= Mm\CV2FPT0WU
BFTC-909 M2DWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HwdmlEPTB;OT6wOlc6QSEQvF2= MXTTRW5ITVJ?
EW-11 NEjFR|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYW2fpdHUUN3ME25MlE4PjV|IN88US=> NGnLRYRUSU6JRWK=
HCE-4 NWTO[opsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrkNIpKSzVyPUmuNlE2PThizszN NHLDfopUSU6JRWK=
BALL-1 NVy2dI5vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPaTWM2OD17LkKxPVA4KM7:TR?= NHLSTmRUSU6JRWK=
SF539 NH\xcGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:4VGlEPTB;OT6yN|U3OiEQvF2= MYHTRW5ITVJ?
CAMA-1 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[1W2lEPTB;OT6yPFEzQCEQvF2= M4nZSXNCVkeHUh?=
C32 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTlwM{OwOlQh|ryP M1LLTHNCVkeHUh?=
NCI-H1703 NHv1OFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rGV2lEPTB;OT6zOFM4PSEQvF2= Mn\CV2FPT0WU
NCI-H1650 NVi3PJgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLZ[Y5KSzVyPUmuOlA6PDZizszN M17nfnNCVkeHUh?=
NCI-H1563 NXrzPYlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUT5c|dQUUN3ME25Mlc3ODNzIN88US=> MWTTRW5ITVJ?
CAL-85-1 NHXrXGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTlwOEezPFMh|ryP NVnVc2xrW0GQR1XS
UM-UC-3 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13xVGlEPTB;OT65OVA{KM7:TR?= M2HDd3NCVkeHUh?=
BxPC-3 NF\1OnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPmVYJIUUN3ME2xNE4xQTd{IN88US=> Ml3RV2FPT0WU
MHH-PREB-1 NGHDRZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD3b4tmUUN3ME2xNE4yQTl7IN88US=> NXGxeG15W0GQR1XS
DEL NInoNYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFyLkO5OFYh|ryP M1jtZ3NCVkeHUh?=
HuCCT1 Ml7sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\XbGlEPTB;MUCuOlA{OyEQvF2= NWDVfpVIW0GQR1XS
OVCAR-4 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFyLki4N|Uh|ryP NV;ZcVNVW0GQR1XS
CAL-72 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zqSGlEPTB;MUCuPVM6OSEQvF2= M{W0bXNCVkeHUh?=
HCC1954 Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC3TWM2OD1zMT6wO|U1KM7:TR?= NVe0ZVZCW0GQR1XS
EFO-21 NHLIUYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;udoVWUUN3ME2xNU4yODR3IN88US=> MV3TRW5ITVJ?
FTC-133 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTFzLkG0NFch|ryP MoTHV2FPT0WU
SK-MEL-24 MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ftS2lEPTB;MUGuNlM3PiEQvF2= MmHSV2FPT0WU
UACC-62 NFS4NXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXEOphKSzVyPUGxMlI{PjhizszN MmDKV2FPT0WU
NCI-H650 Mo\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfyW4dKSzVyPUGxMlI1OThizszN M1H2enNCVkeHUh?=
ALL-PO MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTlTWM2OD1zMT6yOVEzKM7:TR?= MoHtV2FPT0WU
T84 NFHoXXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTFzLkO5NFch|ryP NGDwUmNUSU6JRWK=
IST-MEL1 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LhXWlEPTB;MUGuOFU2QSEQvF2= NYnFTVhrW0GQR1XS
SW626 NVvU[FA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTFzLkW3OVUh|ryP NVv0ZYRmW0GQR1XS
RPMI-2650 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnodox7UUN3ME2xNU42QDh3IN88US=> MoD6V2FPT0WU
MC-IXC Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjCN|RKSzVyPUGxMlY4OjhizszN M3nTbnNCVkeHUh?=
HOP-62 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DLemlEPTB;MUGuOlc3PCEQvF2= Mm\VV2FPT0WU
NOS-1 NGL1eYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjLVpdKSzVyPUGxMlcyODlizszN Mo\LV2FPT0WU
SW1573 MoLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnsR|FKSzVyPUGxMlczQTVizszN NEDmUWlUSU6JRWK=
WM-115 M1S1SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFzLke1PFgh|ryP MX3TRW5ITVJ?
HuO9 NGnvd4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFzLki3O|Qh|ryP NEPmRnJUSU6JRWK=
YAPC M{mwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFzLkmyOVkh|ryP NWDjO2o4W0GQR1XS
MDA-MB-453 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{GxRmlEPTB;MUGuPVUyPSEQvF2= MlnwV2FPT0WU
NCI-H596 M{HHb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWG1O|JiUUN3ME2xNk4xOzZ7IN88US=> MkXxV2FPT0WU
A172 MnfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4GwPGlEPTB;MUKuNFc6QCEQvF2= NILDc2xUSU6JRWK=
RS4-11 NFjPSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnrZYhzUUN3ME2xNk4yPzJ3IN88US=> MY\TRW5ITVJ?
HCC1937 NVvOUJlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rDOmlEPTB;MUKuO|U3PCEQvF2= M{WwT3NCVkeHUh?=
SW837 M1zVd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HD[2lEPTB;MUKuPVAzQCEQvF2= MUDTRW5ITVJ?
NMC-G1 NIDOOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXtTWM2OD1zMj65NlM1KM7:TR?= NWK0ZoJqW0GQR1XS
PFSK-1 M3Xycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIKyZWtKSzVyPUGzMlA3KM7:TR?= NXTSW2prW0GQR1XS
DBTRG-05MG M2LLRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nSRmlEPTB;MUOuNFY{OiEQvF2= MoPMV2FPT0WU
SK-UT-1 NYfQSlB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTF|LkGwPFMh|ryP NE\zXXhUSU6JRWK=
OVCAR-5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\vTndLUUN3ME2xN{4yPTl|IN88US=> NEjX[lhUSU6JRWK=
8505C NG\zS|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTF|LkKwOlch|ryP NFvqOIFUSU6JRWK=
SK-MEL-1 NVjk[mQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXQPXRKSzVyPUGzMlcyOzVizszN MYrTRW5ITVJ?
LK-2 MofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPJNmVsUUN3ME2xN{44PjN7IN88US=> M3XPcHNCVkeHUh?=
OE33 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnpUGtKSzVyPUGzMlc5PiEQvF2= NGLzXGRUSU6JRWK=
Ramos-2G6-4C10 MoDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\zfWlEPTB;MUSuNFIxOiEQvF2= M{DURXNCVkeHUh?=
EW-13 Mm\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\UcGlEPTB;MUSuNFM2OiEQvF2= M2LodHNCVkeHUh?=
NCI-H1793 M1PWSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr2TnozUUN3ME2xOE4zODh5IN88US=> M4fIN3NCVkeHUh?=
BHT-101 MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHGxcXdKSzVyPUG0MlI1OSEQvF2= Mo\QV2FPT0WU
RKO MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HiOmlEPTB;MUSuOVA4PSEQvF2= MmHWV2FPT0WU
NEC8 M2fYPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPobYFKSzVyPUG0MlU1PzJizszN NULtdWt1W0GQR1XS
PANC-10-05 NUnnTIRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zzeWlEPTB;MUSuOlI1PyEQvF2= M1PRcHNCVkeHUh?=
NCI-H2030 MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPnTWM2OD1zND62OFQ5KM7:TR?= MXPTRW5ITVJ?
C2BBe1 Ml2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnBTWM2OD1zND63OlQh|ryP NGfxNm5USU6JRWK=
EM-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWO1RXZTUUN3ME2xOE45PTd4IN88US=> MXTTRW5ITVJ?
HCC1395 NYLpfot7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjiZVlKSzVyPUG0Mlk{OzhizszN MY\TRW5ITVJ?
A2058 NHfHZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF3LkC0NFkh|ryP M2XPWXNCVkeHUh?=
SW1463 NWTYd3g5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTF3LkC0PFUh|ryP M3OwV3NCVkeHUh?=
J82 MoDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K0WmlEPTB;MUWuNFU4KM7:TR?= MmTGV2FPT0WU
CAL-120 NGHqeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnx[4tKSzVyPUG1MlE1PDdizszN NV7mN4IyW0GQR1XS
COLO-824 M3fsbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2naRmlEPTB;MUWuNVU4QSEQvF2= Mke1V2FPT0WU
LNCaP-Clone-FGC NUP1fo4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTF3LkSyOFgh|ryP NYXobm1HW0GQR1XS
CP66-MEL Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF3LkS2PFgh|ryP Ml\aV2FPT0WU
OC-314 M3nUeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULPUWF5UUN3ME2xOU41PzF2IN88US=> MlX2V2FPT0WU
OVCAR-8 Mnf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTF3Lki4OlEh|ryP NGLJPHZUSU6JRWK=
MFE-280 M1jZSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\4OmlEPTB;MU[uNFQ5QCEQvF2= NH34UFhUSU6JRWK=
MHH-NB-11 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTF4LkC4N|kh|ryP NX7KOGs5W0GQR1XS
SW1990 NYnOc2JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUO5SFF1UUN3ME2xOk4yPzV3IN88US=> M1;NWHNCVkeHUh?=
U-266 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fUdWlEPTB;MU[uNlI6QSEQvF2= Mm\TV2FPT0WU
MFM-223 MkjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\PVYM2UUN3ME2xOk4{QTZ3IN88US=> NWnYc5V1W0GQR1XS
L-363 NHL0WHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\CXGlEPTB;MU[uOFU4PyEQvF2= Ml7rV2FPT0WU
MCF7 NX3LUJhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjZTWM2OD1zNj60O|I{KM7:TR?= MX7TRW5ITVJ?
SK-MEL-3 NHz3OYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ThfWlEPTB;MU[uOFc5PyEQvF2= NWPZbGd3W0GQR1XS
HH MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD4botKSzVyPUG2MlUyPjJizszN MmrsV2FPT0WU
no-10 M1yz[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXOTWM2OD1zNj62N|Q{KM7:TR?= NInLcHJUSU6JRWK=
HuP-T3 MmHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jUemlEPTB;MU[uOlU4PiEQvF2= Ml;OV2FPT0WU
QIMR-WIL NWXCZVJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTF4LkexNFUh|ryP M{PTO3NCVkeHUh?=
NCI-H1092 M3nuNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrTS2JKSzVyPUG2Mlg{OTZizszN NYXNVZR2W0GQR1XS
MZ2-MEL NIHN[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF4Lki0NFMh|ryP NGjrRnhUSU6JRWK=
ES3 MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELDbGpKSzVyPUG2MlkyOzRizszN NV2xSZd4W0GQR1XS
COLO-684 M3nOR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTF4Lkm0O|ch|ryP M1q0eXNCVkeHUh?=
NCI-H661 NFTiUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7ocFFrUUN3ME2xOk46Pjl2IN88US=> NVXlR|I2W0GQR1XS
CP50-MEL-B Mly1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTF5LkCzOFMh|ryP MXjTRW5ITVJ?
NCI-H2405 MknuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3n0W2lEPTB;MUeuNVk4PCEQvF2= NEDme4RUSU6JRWK=
U-2-OS MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fVbWlEPTB;MUeuOVMxPyEQvF2= NV3xcoFVW0GQR1XS
RERF-LC-MS MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF5LkW1NFgh|ryP NGPGVZpUSU6JRWK=
NCI-H2342 NXvH[WpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPGTWM2OD1zNz61OVch|ryP MWTTRW5ITVJ?
ES8 NGDtSZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT6SGNbUUN3ME2xO{43ODh5IN88US=> NUC0S4JsW0GQR1XS
MOLT-16 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTF5Lki5N|Qh|ryP MUPTRW5ITVJ?
RH-18 MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7zTWM2OD1zOD6wNFM2KM7:TR?= M4fqPXNCVkeHUh?=
D-283MED NXHQd3BHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzlXFhKSzVyPUG4MlAxQDhizszN MVjTRW5ITVJ?
RCC10RGB MofYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfJZpNFUUN3ME2xPE4xPTV7IN88US=> NF7PT4lUSU6JRWK=
NCI-H1437 M2WzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\3bYRKSzVyPUG4MlE3PDFizszN MWXTRW5ITVJ?
SW982 NFLzV21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi4eWdKSzVyPUG4MlI3PzFizszN MXzTRW5ITVJ?
IST-MES1 NIfvSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnqV4xKSzVyPUG4MlQ1OjhizszN NU\XVpMzW0GQR1XS
A704 NXPnSpJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP5TWM2OD1zOD60O|U{KM7:TR?= NWTRZYpMW0GQR1XS
ESS-1 NX7GS4d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTF6LkWyNFUh|ryP MkjsV2FPT0WU
SCH Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;HTWM2OD1zOD62OFU3KM7:TR?= Ml:4V2FPT0WU
COLO-320-HSR NVrWZZZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfNZmRKSzVyPUG4Mlc1PiEQvF2= NXXNfpJ{W0GQR1XS
Mo-T M3\RW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmThTWM2OD1zOD64NlA1KM7:TR?= M2HCSHNCVkeHUh?=
Saos-2 MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP0OotDUUN3ME2xPU4yOTZ{IN88US=> M4\nfHNCVkeHUh?=
SW684 M3vrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\vSGlEPTB;MUmuNVMzPiEQvF2= NYn2fIhNW0GQR1XS
KMOE-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PBNmlEPTB;MUmuNlI1OiEQvF2= MlPXV2FPT0WU
MMAC-SF NYjzeJQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHLTWM2OD1zOT6yOlA4KM7:TR?= M3\HO3NCVkeHUh?=
JAR MmfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DPV2lEPTB;MUmuNlk6KM7:TR?= NVfadJBPW0GQR1XS
SK-MEL-28 NHLBdmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nuUWlEPTB;MUmuN|M3OyEQvF2= MV3TRW5ITVJ?
KNS-81-FD MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTF7LkW0Olgh|ryP NFXhfGFUSU6JRWK=
ES7 NGC0[ZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTF7Lk[yPVIh|ryP M3rieXNCVkeHUh?=
AsPC-1 NYjvUnc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfw[ZFKSzVyPUG5MlY1PzFizszN M{TjfnNCVkeHUh?=
NCI-H1155 NIHDdHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LtTGlEPTB;MUmuO|I{QCEQvF2= MVHTRW5ITVJ?
KYSE-510 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDCO2s6UUN3ME2xPU45PzR6IN88US=> M3O2RnNCVkeHUh?=
ES1 NF7WSFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID2fWFKSzVyPUG5MlkzOTNizszN MXPTRW5ITVJ?
PC-3 MlrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTF7Lkm2NFQh|ryP M1;rR3NCVkeHUh?=
GCT MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn20TWM2OD1{MD6zNFI3KM7:TR?= Mn;UV2FPT0WU
KARPAS-299 NVrafVdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEj4U5BKSzVyPUKwMlM1OjJizszN M17xWXNCVkeHUh?=
DOHH-2 MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnCOmdIUUN3ME2yNE42PDZ|IN88US=> MljZV2FPT0WU
COLO-741 Mki2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTJyLk[2JO69VQ>? MVzTRW5ITVJ?
NCI-H1395 NEnU[|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJyLk[2PVch|ryP M3HhbnNCVkeHUh?=
HCC1187 MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLwRWFKSzVyPUKwMlY4OzRizszN NEiyVmdUSU6JRWK=
Becker Ml;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPMOll7UUN3ME2yNE44OjBzIN88US=> NVvSd4hQW0GQR1XS
LU-134-A M2T3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrqSVFwUUN3ME2yNU4yODJ4IN88US=> M2XVdXNCVkeHUh?=
MKN45 NIrqOGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJzLkG1OVEh|ryP MoLpV2FPT0WU
LC-2-ad NUjZUGtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJzLkK3Nlkh|ryP MVHTRW5ITVJ?
EW-24 M1;BbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDmXFBKSzVyPUKxMlM6PDVizszN NFvKSpJUSU6JRWK=
SK-N-AS NWPCVVZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGniTItKSzVyPUKxMlgzPzZizszN MlX0V2FPT0WU
NCI-H2052 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7LTWM2OD1{MT64PVY{KM7:TR?= NWrVPIFMW0GQR1XS
A4-Fuk MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGiwXGtKSzVyPUKyMlE1OTlizszN NVPYdGpwW0GQR1XS
NB10 NVroXHIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPUNnNKSzVyPUKyMlI{PzFizszN NVTFbGNmW0GQR1XS
CHP-212 MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DtO2lEPTB;MkKuN|IzOiEQvF2= NUnoRZI6W0GQR1XS
KM12 MkLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zPOWlEPTB;MkKuN|U3KM7:TR?= Mne3V2FPT0WU
JEG-3 NVq1eG8zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTJ{LkO3PEDPxE1? MnXwV2FPT0WU
LN-405 NICzXnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTJ{LkW5NVMh|ryP NWDGcop2W0GQR1XS
HCT-15 NWDTcmp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJ{Lke0OFEh|ryP NFLu[JhUSU6JRWK=
MLMA NWfrOXp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHDWHdKSzVyPUKyMlc1PyEQvF2= NHHGNFZUSU6JRWK=
GI-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzjTWM2OD1{Mj63OlU5KM7:TR?= M4Pp[HNCVkeHUh?=
RT-112 M1fTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTMOHBYUUN3ME2yNk45PjF4IN88US=> NUjvPWo5W0GQR1XS
MPP-89 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LtWGlEPTB;MkKuPFY3OSEQvF2= NYjzdoRlW0GQR1XS
A3-KAW M4HEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXiOZlIUUN3ME2yN{4yODB|IN88US=> NVzxbJJ6W0GQR1XS
KALS-1 MoG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XYSmlEPTB;MkOuNVQyPCEQvF2= Mn\jV2FPT0WU
SF126 NX\vOZVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXflU4tTUUN3ME2yN{43QTJ2IN88US=> NIOzUZNUSU6JRWK=
SiHa NVPEcmdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz5N2VJUUN3ME2yN{46OzJ5IN88US=> NHPobVBUSU6JRWK=
MDA-MB-415 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELadnRKSzVyPUKzMlk1QTlizszN NYnseZl4W0GQR1XS
Daoy MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJ2LkGyOkDPxE1? Moq0V2FPT0WU
COR-L23 M4THN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M365U2lEPTB;MkSuNVc3PyEQvF2= M4LnWXNCVkeHUh?=
KG-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7wTWM2OD1{ND6xPVI5KM7:TR?= NFG4bVhUSU6JRWK=
L-428 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXtU|BuUUN3ME2yOE42PzlzIN88US=> MonHV2FPT0WU
NCI-H520 M{CyZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXnWYQ2UUN3ME2yOE45QDZzIN88US=> NWDSVmFtW0GQR1XS
COLO-792 NIPa[|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjJ[lV6UUN3ME2yOU4zPzN{IN88US=> MWrTRW5ITVJ?
NB12 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nTXmlEPTB;MkWuNlk1PyEQvF2= M{fPdHNCVkeHUh?=
GAK M1[x[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfNTWM2OD1{NT6yPVY{KM7:TR?= MlfIV2FPT0WU
SW780 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXP0RXlSUUN3ME2yOU4{OjZ2IN88US=> NGLrTYdUSU6JRWK=
GB-1 NYrsTY5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJ3LkSwOlkh|ryP MUDTRW5ITVJ?
P12-ICHIKAWA MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXHTWM2OD1{NT60O|g2KM7:TR?= NGnBblNUSU6JRWK=
NCI-H1651 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ3LkW5O{DPxE1? MkL4V2FPT0WU
KE-37 Mo[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTJ3LkezNVUh|ryP MXLTRW5ITVJ?
CCRF-CEM M3TRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHVNGN3UUN3ME2yOU46PjdizszN MnXoV2FPT0WU
SF295 NUW5NJp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWL0R2tpUUN3ME2yOk4xPDJ3IN88US=> NE\F[4FUSU6JRWK=
G-361 MlfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS1TWM2OD1{Nj6xNFI4KM7:TR?= NF\weY5USU6JRWK=
HOP-92 NVzvNZA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDRTGVKSzVyPUK2MlEzOjZizszN MX;TRW5ITVJ?
UMC-11 M{O0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn1V3pKSzVyPUK2MlQ2OTRizszN NIrRZnVUSU6JRWK=
IST-SL1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TPWGlEPTB;Mk[uOlU6OSEQvF2= M1v6eXNCVkeHUh?=
TE-11 NWK4fVNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTJ4Lke3OVIh|ryP NVzxPI9oW0GQR1XS
NCI-H1304 NHzydoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fKPWlEPTB;Mk[uPVExQCEQvF2= MorFV2FPT0WU
SJSA-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInjbW9KSzVyPUK3MlAyPzZizszN MnrkV2FPT0WU
BCPAP NY\y[YlVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zob2lEPTB;MkeuNVM4KM7:TR?= MmXBV2FPT0WU
HTC-C3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nET2lEPTB;MkeuNlU3OSEQvF2= MVfTRW5ITVJ?
EW-16 MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJ5LkK5OFch|ryP NYj3enNDW0GQR1XS
HT-144 MknqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrpTWM2OD1{Nz60NFMzKM7:TR?= NVezTVJUW0GQR1XS
MHH-ES-1 NVvxenlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjp[YtyUUN3ME2yO{41PDR5IN88US=> Mnm4V2FPT0WU
T98G MkfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrBTWM2OD1{Nz61PFQ3KM7:TR?= MYLTRW5ITVJ?
RPMI-8866 NF\Jb3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHXU|d[UUN3ME2yO{44PTZ{IN88US=> MYnTRW5ITVJ?
BEN MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fW[mlEPTB;MkeuPFUyPyEQvF2= NWnvdYtWW0GQR1XS
MDA-MB-231 NYHSWnRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTJ6LkK3PVUh|ryP M2LzSXNCVkeHUh?=
HuH-7 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJ6LkSwNlgh|ryP MXvTRW5ITVJ?
SK-N-FI NEfxc3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\xe5ZKSzVyPUK4MlQ{OyEQvF2= MkHTV2FPT0WU
AN3-CA NIWyPFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2wTWM2OD1{OD60N|k2KM7:TR?= M4HQTHNCVkeHUh?=
EGI-1 M3jrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHRTWM2OD1{OD61PVI5KM7:TR?= NXXJO3R3W0GQR1XS
697 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJ6Lk[zN|Eh|ryP M4SxVnNCVkeHUh?=
TCCSUP M33qeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXsTWM2OD1{OD62OFE5KM7:TR?= NV64NpdnW0GQR1XS
GR-ST NYjUXIVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJ6Lk[2PVYh|ryP M1OxVXNCVkeHUh?=
SK-N-DZ MlrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nzXmlEPTB;MkiuOlg5PSEQvF2= NEnoTppUSU6JRWK=
MIA-PaCa-2 NXnoTmRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP4TWM2OD1{OD63PVU6KM7:TR?= MkPJV2FPT0WU
IGR-1 NIXoWJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Hhc2lEPTB;MkiuPFg4PCEQvF2= MYrTRW5ITVJ?
BFTC-905 M2r4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzCOG1XUUN3ME2yPU4zPzB3IN88US=> NYfFXlNZW0GQR1XS
NCI-H1581 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfTdHRKSzVyPUK5MlMyPDVizszN Mn3YV2FPT0WU
RD NH;RUXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHBNZhOUUN3ME2yPU42OjN|IN88US=> NUL3PFRWW0GQR1XS
SF268 NEOzOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJ7LkW5N|Eh|ryP M1;menNCVkeHUh?=
SHP-77 NWe5XGpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HvTGlEPTB;MkmuOlE5OiEQvF2= Mnj4V2FPT0WU
D-566MG NHXJb5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzj[Xg4UUN3ME2yPU46Ozl|IN88US=> MULTRW5ITVJ?
TGBC1TKB NE\uT|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7RTWM2OD1|MD6xNlM5KM7:TR?= MULTRW5ITVJ?
MEL-HO NXntcpk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGT5Z5pKSzVyPUOwMlE1OjNizszN MlrqV2FPT0WU
SJRH30 M2\2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jm[2lEPTB;M{CuNlExQCEQvF2= MVjTRW5ITVJ?
D-336MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\1TWM2OD1|MD6yPFkzKM7:TR?= NX\XTXo1W0GQR1XS
C3A M1jTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LlZmlEPTB;M{CuNlkzPyEQvF2= NFLBTFFUSU6JRWK=
Calu-6 M17kfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nYc2lEPTB;M{CuNlk3OyEQvF2= M4LHW3NCVkeHUh?=
MZ1-PC NF2zV|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTNyLkO5N{DPxE1? NXv3UHNtW0GQR1XS
KYSE-70 MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTpXY1uUUN3ME2zNE42OTF2IN88US=> M{XmNHNCVkeHUh?=
CAPAN-1 M4\XT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTmelZRUUN3ME2zNE42OThzIN88US=> NID1bZFUSU6JRWK=
DK-MG NX3YSYtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTNyLkW0OVYh|ryP NIWwOFJUSU6JRWK=
SK-HEP-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPpTWM2OD1|MD62N|I3KM7:TR?= MljlV2FPT0WU
MS-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTNyLki4PFkh|ryP NFTZbnZUSU6JRWK=
GI-ME-N M{DTc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvkTWM2OD1|MT6wOVcyKM7:TR?= NGfLZ2ZUSU6JRWK=
NCI-H510A MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3DVGpKSzVyPUOxMlQxODZizszN M4TkUHNCVkeHUh?=
NB17 MoLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfRTWM2OD1|MT61NVg2KM7:TR?= MXvTRW5ITVJ?
639-V NFW3OpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;JXHljUUN3ME2zNU42OjR|IN88US=> M4fHOnNCVkeHUh?=
CAL-51 NFS0WYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\KPIRKUUN3ME2zNU42PjZ5IN88US=> MnLwV2FPT0WU
HGC-27 NFeyUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TZXWlEPTB;M{GuOVg4OyEQvF2= MVvTRW5ITVJ?
GOTO MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTNzLki1NFYh|ryP MmX1V2FPT0WU
ChaGo-K-1 MkGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jCR2lEPTB;M{KuNFA4KM7:TR?= M37kTXNCVkeHUh?=
RO82-W-1 M1LQcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXJdmhKSzVyPUOyMlE3ODRizszN MojlV2FPT0WU
SH-4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfGWllKSzVyPUOyMlE5PThizszN NUTY[oNEW0GQR1XS
A204 MknKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTN{LkWwOlkh|ryP NIjPWlNUSU6JRWK=
DMS-273 NWezdHlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnGWHc1UUN3ME2zNk42OzJ{IN88US=> M3;nb3NCVkeHUh?=
KGN NHGyXHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3ToTmlEPTB;M{KuOlM{KM7:TR?= MonoV2FPT0WU
SK-MEL-2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTN{Lk[1Nlch|ryP MoK3V2FPT0WU
NCI-H2228 NHyxeYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vFWGlEPTB;M{KuOlYxOiEQvF2= NVzwSXdCW0GQR1XS
MKN28 MmXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW3VmxKSzVyPUOyMlc5OzhizszN M17kTnNCVkeHUh?=
H-EMC-SS M3Oze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN{Lkm2O|gh|ryP NIf6d|RUSU6JRWK=
ATN-1 NES4e2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTN|LkG0NVYh|ryP M33iS3NCVkeHUh?=
D-263MG NV;HbnU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHe2NotKSzVyPUOzMlg{PzhizszN NH[0RotUSU6JRWK=
LU-135 M2C1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PpVGlEPTB;M{OuPFgzQSEQvF2= MXjTRW5ITVJ?
C8166 MnfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnNTVM5UUN3ME2zN{45QDV2IN88US=> MWrTRW5ITVJ?
T-24 NX7C[IxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELkSmVKSzVyPUO0MlAzODVizszN M{DpVXNCVkeHUh?=
Mewo NWrjNW1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTN2LkGzOFkh|ryP MUXTRW5ITVJ?
22RV1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzNdG5KSzVyPUO0MlE4PTRizszN NFzRSlFUSU6JRWK=
KM-H2 M{X1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn2SpJKSzVyPUO0MlE4PzlizszN M2iyWXNCVkeHUh?=
NCI-H2122 M{Hkc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFqyZ3ZKSzVyPUO0MlM1PzFizszN NXzsbmRvW0GQR1XS
ABC-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXyTWM2OD1|ND6zOlk{KM7:TR?= NHHRWGFUSU6JRWK=
NCI-H1355 Ml7oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTN2LkO4PFkh|ryP MXzTRW5ITVJ?
NOMO-1 MoHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3uT4hKSzVyPUO0MlU4ODNizszN M{D5PHNCVkeHUh?=
MZ7-mel MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7uPWxKSzVyPUO0MlY1QDdizszN M1zLbHNCVkeHUh?=
NCI-H810 NEjSNIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\NUYtKSzVyPUO0MlczPzhizszN NH\QcJdUSU6JRWK=
D-392MG M1fvdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLETWM2OD1|NT6wOVY2KM7:TR?= NYT5cXRpW0GQR1XS
LB771-HNC MlnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\xUGlEPTB;M{WuNVY2QCEQvF2= M2nRNXNCVkeHUh?=
COLO-679 M3\qUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\s[mpzUUN3ME2zOU4{QDhizszN M1jtRnNCVkeHUh?=
SK-PN-DW NEL3dFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInLdWNKSzVyPUO1MlQ{PjlizszN M2DMNHNCVkeHUh?=
VA-ES-BJ MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7kTWM2OD1|NT60OlQ6KM7:TR?= NIG4[3JUSU6JRWK=
KNS-42 M{exWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnmzTWM2OD1|NT61PFI3KM7:TR?= M2LvOnNCVkeHUh?=
RVH-421 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTN3Lke2OFUh|ryP NFTLXHdUSU6JRWK=
P30-OHK M1rpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu4TWM2OD1|NT64O|UzKM7:TR?= NVrOeWNuW0GQR1XS
G-402 M{LmfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTN3Lkm4Olch|ryP MWHTRW5ITVJ?
S-117 NFS3TJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfVTWM2OD1|Nj6zNFA5KM7:TR?= NU\6UXgzW0GQR1XS
RXF393 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTlTWM2OD1|Nj6zO|g2KM7:TR?= MVfTRW5ITVJ?
LCLC-103H M{HpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TzcmlEPTB;M{[uO|gxOyEQvF2= MX;TRW5ITVJ?
U-118-MG NVW1cYlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3z0WGlEPTB;M{[uPFg1PyEQvF2= NW\JbYdRW0GQR1XS
8-MG-BA M4PIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnETWM2OD1|Nj65OFg{KM7:TR?= NVLPemdPW0GQR1XS
MFH-ino NXrxWW1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjsOm81UUN3ME2zO{4{OzdzIN88US=> Mn:5V2FPT0WU
NCI-H23 Ml;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\iOHVxUUN3ME2zO{41OTl4IN88US=> MkTJV2FPT0WU
NCI-H446 M1nr[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTN5LkS4OlIh|ryP NEmyUG5USU6JRWK=
LU-99A NHnhRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGiyTlBKSzVyPUO3MlU4OzFizszN NVXIWHM6W0GQR1XS
KP-N-YN Ml20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVu5N25bUUN3ME2zO{43OTl3IN88US=> MkDaV2FPT0WU
SCC-9 MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTwTWM2OD1|Nz63PFM5KM7:TR?= MkDDV2FPT0WU
EFM-19 M4XJSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HZcmlEPTB;M{euO|k3PyEQvF2= MYjTRW5ITVJ?
A427 NXXrSJpJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LjNmlEPTB;M{euPVExPyEQvF2= M3;SXHNCVkeHUh?=
LB831-BLC MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTFelJKSzVyPUO4MlYxOzlizszN MYjTRW5ITVJ?
HOS NIfVfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rIdGlEPTB;M{muOlI4OyEQvF2= MmPXV2FPT0WU
LAN-6 MnzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\tSGlEPTB;NECuNFEyOiEQvF2= Ml3mV2FPT0WU
U251 NF7HW3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTRyLkSwOVQh|ryP NHzGWoRUSU6JRWK=
SNU-387 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3R[IhMUUN3ME20NE41PTV|IN88US=> NIrER|dUSU6JRWK=
DMS-79 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInqXoxKSzVyPUSwMlU5QDlizszN NYXEb4JRW0GQR1XS
SK-LU-1 NV7iemhmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rKVmlEPTB;NECuOlU3QCEQvF2= MV\TRW5ITVJ?
HT NGrRb5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoG0TWM2OD12MD62OlM6KM7:TR?= MVnTRW5ITVJ?
KP-N-YS NGnwbZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2CzXGlEPTB;NECuOlc3QCEQvF2= MlzqV2FPT0WU
DMS-114 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTRyLkizO|Qh|ryP M{GyW3NCVkeHUh?=
HUTU-80 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zEdWlEPTB;NEGuNFU3QSEQvF2= Ml\2V2FPT0WU
ONS-76 NW\4e5g1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHmSGpKSzVyPUSxMlQ4ODlizszN MUfTRW5ITVJ?
A673 M1HBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjGZpBKSzVyPUSxMlUyPTdizszN NYLnSGJOW0GQR1XS
HPAF-II NVO0WJdkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmiyTWM2OD12MT62O|A6KM7:TR?= MVLTRW5ITVJ?
UACC-257 MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDKe3lKSzVyPUSxMlc{PjlizszN NUn4fI5uW0GQR1XS
EW-22 M3rSZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLrTWM2OD12MT64Olk4KM7:TR?= NVzmN4dWW0GQR1XS
NCI-H1755 NVfBOHNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDmXnh1UUN3ME20NU45PzJ3IN88US=> NUL0W216W0GQR1XS
KYSE-150 M4PwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:5T2lEPTB;NEKuNVc5OiEQvF2= MVXTRW5ITVJ?
CGTH-W-1 NXH1N|duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu2RnU{UUN3ME20Nk41QTV3IN88US=> M{CzTHNCVkeHUh?=
NB13 MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTR{Lk[yNVch|ryP NEPGPXVUSU6JRWK=
SW872 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7TXHJLUUN3ME20Nk43OzNzIN88US=> MlPpV2FPT0WU
KP-4 MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTR{Lki4N|Ih|ryP MXzTRW5ITVJ?
HCC38 NFG4c3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWC5WJY6UUN3ME20Nk46PjF6IN88US=> MX;TRW5ITVJ?
BB49-HNC M1;vVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD5e2ZDUUN3ME20N{4zOzV4IN88US=> NGL5Z45USU6JRWK=
CAL-62 NXvHdJFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTR|LkSwNlgh|ryP MoHTV2FPT0WU
NCI-H2029 Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfSTWM2OD12Mz61OVgyKM7:TR?= MlWzV2FPT0WU
M14 NFrQSmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLLOY5KSzVyPUS0MlE{OzJizszN MmDFV2FPT0WU
COLO-680N NWLlboIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3IW2NKSzVyPUS0MlM{QSEQvF2= NWTvblkyW0GQR1XS
Hs-578-T MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37oWmlEPTB;NEWuNFI6PCEQvF2= NWDsPXlJW0GQR1XS
MSTO-211H Ml:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvpe5M1UUN3ME20OU46PDh{IN88US=> NYfHNGFtW0GQR1XS
EW-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTR3Lkm2PFkh|ryP NFfReJRUSU6JRWK=
SW948 MkLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTR4LkS0OlIh|ryP M2CwS3NCVkeHUh?=
NCI-H460 NH:3[5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTR4LkWyN{DPxE1? MnrwV2FPT0WU
CAS-1 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEn2V4dKSzVyPUS2Mlc4ODFizszN MlT3V2FPT0WU
TGBC11TKB Mnj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv2RmtKSzVyPUS3MlE4PzdizszN NVLweVhVW0GQR1XS
HD-MY-Z Mnz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvXVYxGUUN3ME20PE44QDZizszN M2rOPHNCVkeHUh?=
NCI-H226 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfVVlZpUUN3ME20PU44Pzh3IN88US=> M3iweHNCVkeHUh?=
PA-1 NF\nNIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTR7LkizN|Uh|ryP MlfQV2FPT0WU
LB2518-MEL MoLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7xeohKSzVyPUS5Mlg4OjNizszN NVX2UYRGW0GQR1XS
A101D MlHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTR7Lkm0NlUh|ryP M3TNN3NCVkeHUh?=
NCI-H2087 M4D1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PxS2lEPTB;NEmuPVY5OiEQvF2= M4DrSHNCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CIP2A / p-AKT / AKT / PARP; 

PubMed: 25537503     


Time-dependent effects of afatinib on CIP2A, p-AKT and apoptosis-related proteins in the sensitive H358 and resistant H460 cells. Cells were exposed to 10 μM afatinib for up to 48 hours. Immunoblots were scanned and quantitated to determine the ratio of the level of CIP2A to actin. Data are mean ± SD. n = 3 for the different time intervals.

p-EGFR / p-IGF1R / p-ERK / p-AKT; 

PubMed: 26052929     


Effects of afatinib on EGFR and IGF1R Signaling Pathways. H1975 cells were treated with afatinib with various doses and cell lysates were subjected to Western blot analysis. Afatinib effectively inhibits p-EGFR and p-ERK while p-AKT was partially inhibited. IGF1R phosphorylation was increased upon afatinib treatment in H1975 cells.

p-VEGFR2 / VEGFR2 / JAG1 / DLL4 / NICD1 ; 

PubMed: 28533486     


HUVECs were cultured in the presence of Vatalanib (100 nM) or DBZ (10 nM) for 1 h and then treated for 15 min with rhgal-3 (37 nM) and cultured for additional 6 hrs. After this period, the total protein was isolated and the protein levels of galectin-3, NICD1, DLL4, JAG1, VEGFR2 and VEGFR2-p were assessed by Western blot. β-actin was used as a loading control.

25537503 26052929 28533486
Growth inhibition assay
Cell apoptosis; 

PubMed: 25537503     


Dose-dependent effects of afatinib on apoptosis. Data are mean ± SD. n = 3 for each concentration. *, p < 0.05, **, p < 0.01, vs. no afatinib. 

Cell viability; 

PubMed: 26515464     


A. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion and L858R. The proportional cell viability is shown. B. MTS assay for Ba/F3 cells harboring EGFR exon 19 deletion+T790M and L858R+T790M. The proportional cell viability is shown. C. MTS assay for Ba/F3 cells harboring wild type EGFR. The proportional cell viability is shown. Erlotinib, afatinib, osimertinib, and rociletinib were used as EGFR-TKIs. Error bars indicate standard deviation.

25537503 26515464
Immunofluorescence
p65; 

PubMed: 26317651     


Effects of different treatments on the nuclear translocation of the NF-κB subunit p65. A2780T cells were treated with 2.5 μM afatinib for 48 hours, or 10 μM PDTC for 2 hours. Subsequently, the NF-κB subunit p65 (red) was localized by immunofluorescence and a confocal microscopy. Nuclei were stained with DAPI (blue). Scale bar = 10 μM.

vacuoles; 

PubMed: 29713246     


Autophagy activation upon treatment with Afatinib and Sorafenib was validated using immunofluorescence in order to visualize a creation of autophagosomes; ×60 magnification. DMSO treatment was used as control. Green—autophagy vacuoles; Blue—Hoechst, nuclear staining. 

26317651 29713246
In vivo Daily oral administration of BIBW2992 at 20 mg/kg for 25 days results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%. Reduced phosphorylation of EGFR and AKT is confirmed by immunohistochemical staining of tissue sections. Therefore, like lapatinib and neratinib, BIBW2992 is a next generation tyrosine kinase inhibitor (TKI) that inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases irreversibly. BIBW2992 is not only active against EGFR mutations targeted by first generation TKIs like Erlotinib or Gefitinib, but also against those insensitive to these standard therapies. [1]

Protocol

Kinase Assay:

[1]

- Collapse

In vitro kinase activity assays:

The wild type tyrosine kinase domain of the human EGFR as well as that of the EGFR L858R/T790M double mutant are fused to Glutathione-S-transferase (GST), and extracted. Enzyme activity is then assayed in the presence of the inhibitor BIBW2992, serially diluted in 50% DMSO. A random polymer pEY (4:1) is used as substrate and biotinylated pEY (bio-pEY) is added as a tracer substrate. The kinase domain of HER2 is cloned using the baculovirus system and extracted similarly to that of EGFR kinase. Details of assays for EGFR, HER2, SRC, BIRK and VEGFR2 kinase activity are available in Supplementary information.
Cell Research:

[1]

- Collapse
  • Cell lines: NSCLC cells
  • Concentrations: 0-10 μM
  • Incubation Time: 1 hour
  • Method:

    1 × 104 NSCLC cells are transferred into each well of a 96-well plate and cultured overnight in serum-free media for the EGFR phosphorylation assay. After addition of BIBW2992 on the next day, the plates are incubated at 37 °C for 1 hour. EGF-stimulation is done using 100 ng/mL for 10 min at room temperature. Cells are washed with ice cold PBS, extracted with 120 μL HEPEX buffer per well and shaken at room temperature for 1 hour. In all 2 × 104 cells per well is used for the HER2 phosphorylation assay. Streptavidin precoated plates are coated with anti-EGFR-biotin at 1:100 dilution in blocking buffer and c-erb2/HER2 oncoprotein Ab-5(Clone N24)-Biotin. Cell extracts is then transferred to the antibody-coated wells and incubated at room temperature for 1 hour. Extinction is measured at 450 nm.


    (Only for Reference)
Animal Research:

[1]

- Collapse
  • Animal Models: Athymic NMRI-nu/nu female mice
  • Formulation: In 0.5% methocellulose-0.4% polysorbate-80 (Tween 80)
  • Dosages: 20 mg/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 97 mg/mL (199.61 mM)
Ethanol 15 mg/mL (30.86 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.94
Formula

C24H25ClFN5O3

CAS No. 439081-18-2
Storage powder
in solvent
Synonyms N/A
Smiles CN(C)C/C=C/C(=O)NC1=CC2=C(NC3=CC=C(F)C(=C3)Cl)N=CN=C2C=C1OC4CCOC4

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03711422 Not yet recruiting Drug: Afatinib Non-small Cell Lung Cancer|Leptomeningeal Disease|Central Nervous System Metastases National Cancer Centre Singapore October 2018 Phase 1
NCT03083678 Recruiting Drug: Afatinib Chordoma Leiden University Medical Center|Chordoma Foundation|Boehringer Ingelheim June 21 2018 Phase 2
NCT03370770 Active not recruiting Drug: Afatinib|Drug: Osimertinib Carcinoma Non-Small-Cell Lung Boehringer Ingelheim December 28 2017 --
NCT02423525 Recruiting Drug: Afatinib Brain Cancer Santosh Kesari|Boehringer Ingelheim|John Wayne Cancer Institute December 2016 Phase 1
NCT02695290 Terminated Drug: Afatinib Carcinoma Non-Small-Cell Lung|ErbB Receptors Boehringer Ingelheim March 17 2016 Phase 4
NCT02171741 Completed Drug: BIBW 2992|Drug: Docetaxel Neoplasms Boehringer Ingelheim April 2005 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    What’s the recommendation about reconstitution of the compound for in vivo animal study?

  • Answer:

    For in vivo experiment of afatinib, we recommend 0.5% methylcellulose/0.2% Tween 80 as vehicle.

EGFR Signaling Pathway Map

EGFR Inhibitors with Unique Features

Related EGFR Products

Tags: buy Afatinib (BIBW2992) | Afatinib (BIBW2992) supplier | purchase Afatinib (BIBW2992) | Afatinib (BIBW2992) cost | Afatinib (BIBW2992) manufacturer | order Afatinib (BIBW2992) | Afatinib (BIBW2992) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID