Name: Articaine HCl
Brand: Selleck Chemicals
SKU: S3150
Availability: InStock
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Batch: S315001 DMSO]64 mg/mL]false]Water]64 mg/mL]false]Ethanol]64 mg/mL]false Purity: 99.70%

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COA
NMR
HPLC
SDS
Datasheet

99.70

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
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Solubility

In vitro
Batch:

DMSO : 64 mg/mL (199.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 64 mg/mL

Ethanol : 64 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight	320.84	Formula	C₁₃H₂₀N₂O₃S.HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	23964-57-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Ultracaine			Smiles	CCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC.Cl

Mechanism of Action

In vivo

The time to maximum drug concentrations of articaine occurs about 10 to 15 minutes after submucosal injection of articaine 4% 80 mg. The elimination half-time of articaine is about 20 minutes. Articaine is better able to diffuse through soft tissue and bone than other local anaesthetics, the concentration of articaine in the alveolus of a tooth in the upper jaw after extraction is about 100 times higher than that in systemic circulation. Articaine: VAS (Visual Analogue Scale) scores (from 0 to 10 cm) by patients 4 to < 13 years of age are 0.5 for simple procedures and 1.1 for complex procedures, and average investigator scores are 0.4 and 0.6 for simple and complex procedures, respectively. No serious adverse events related to the articaine occurres, the only adverse event considered related to articaine is accidental lip injury in one patient. Articaine results in success rate of 64.5% in electronic pulp testing in healthy adult volunteers injected with 4% articaine. Articaine infiltration produces significantly more episodes of no response to maximum stimulation in first molars than lidocaine. Mandibular buccal infiltration is more effective with 4% articaine with epinephrine compared to 2% lidocaine with epinephrine. Articaine (4%) results in the success rate of 24% for the inferior alveolar nerve block in randomized, double-blind study. Articaine formulation results in successful pulpal anesthesia ranged from 75 to 92 percent and onset of pulpal anesthesia ranged from 4.2 to 4.7 minutes in healthy volunteer. For articaine, 4 percent (two of 56) of the subjects reported swelling and no subjects reported bruising. Ninety-eight percent (59 of 60) of the subjects had lip numbness with the articaine solution.

References

[1] https://pubmed.ncbi.nlm.nih.gov/9435991/
[2] https://pubmed.ncbi.nlm.nih.gov/10969438/
[3] https://pubmed.ncbi.nlm.nih.gov/16554198/

[4] https://pubmed.ncbi.nlm.nih.gov/15273637/
[5] https://pubmed.ncbi.nlm.nih.gov/17670879/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04759339	Completed	Healthy	American Genomics LLC	February 24 2021	Phase 1
NCT04865848	Terminated	Anesthesia	University of Illinois at Chicago	June 5 2019	Not Applicable
NCT03174860	Completed	Pulpitis - Irreversible\|Anesthesia Local	Cairo University	October 2016	Phase 2\|Phase 3
NCT01496846	Completed	Irreversible Pulpitis	University of Michigan\|Dentsply International	September 2011	Phase 4

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Articaine HCl NF-κB inhibitor

Chemical Structure

Molecular Weight: 320.84