Articaine HCl

Catalog No.S3150 Synonyms: Ultracaine

Articaine HCl Chemical Structure

Molecular Weight(MW): 320.84

Articaine is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.

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In DMSO USD 130 In stock
USD 60 In stock
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Purity & Quality Control

Biological Activity

Description Articaine is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.
In vivo The time to maximum drug concentrations of articaine occurs about 10 to 15 minutes after submucosal injection of articaine 4% 80 mg. The elimination half-time of articaine is about 20 minutes. Articaine is better able to diffuse through soft tissue and bone than other local anaesthetics, the concentration of articaine in the alveolus of a tooth in the upper jaw after extraction is about 100 times higher than that in systemic circulation. [1] Articaine: VAS (Visual Analogue Scale) scores (from 0 to 10 cm) by patients 4 to < 13 years of age are 0.5 for simple procedures and 1.1 for complex procedures, and average investigator scores are 0.4 and 0.6 for simple and complex procedures, respectively. No serious adverse events related to the articaine occurres, the only adverse event considered related to articaine is accidental lip injury in one patient. [2] Articaine results in success rate of 64.5% in electronic pulp testing in healthy adult volunteers injected with 4% articaine. Articaine infiltration produces significantly more episodes of no response to maximum stimulation in first molars than lidocaine. Mandibular buccal infiltration is more effective with 4% articaine with epinephrine compared to 2% lidocaine with epinephrine. [3] Articaine (4%) results in the success rate of 24% for the inferior alveolar nerve block in randomized, double-blind study. [4] Articaine formulation results in successful pulpal anesthesia ranged from 75 to 92 percent and onset of pulpal anesthesia ranged from 4.2 to 4.7 minutes in healthy volunteer. For articaine, 4 percent (two of 56) of the subjects reported swelling and no subjects reported bruising. Ninety-eight percent (59 of 60) of the subjects had lip numbness with the articaine solution. [5]

Protocol

Solubility (25°C)

In vitro DMSO 64 mg/mL (199.47 mM)
Water 64 mg/mL (199.47 mM)
Ethanol 64 mg/mL (199.47 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 320.84
Formula

C13H20N2O3S.HCl

CAS No. 23964-57-0
Storage powder
in solvent
Synonyms Ultracaine

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03318952 Not yet recruiting Anesthesia Dental|Pain Postoperative Boston University April 2019 Phase 4
NCT03880409 Recruiting Overcoming the Failure of Anesthesia in the Mandibular Teeth Taibah University April 9 2019 Phase 1
NCT03318952 Not yet recruiting Anesthesia Dental|Pain Postoperative Boston University April 2019 Phase 4
NCT03880409 Recruiting Overcoming the Failure of Anesthesia in the Mandibular Teeth Taibah University April 9 2019 Phase 1
NCT03612323 Not yet recruiting Pulpitis - Irreversible Cairo University November 2018 Early Phase 1
NCT03612323 Not yet recruiting Pulpitis - Irreversible Cairo University November 2018 Early Phase 1

Tech Support

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