APD597

For research use only.

Catalog No.S0110 Synonyms: JNJ-38431055

APD597 Chemical Structure

CAS No. 897732-93-3

APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with EC50 of 46 nM for hGPR119 and an inhibitor of Cytochrome P450 2C9 (CYP2C9) with IC50 of 5.8 μM. APD-597 (JNJ-38431055) is developed for treating Type 2 diabetes (T2D).

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Biological Activity

Description APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with EC50 of 46 nM for hGPR119 and an inhibitor of Cytochrome P450 2C9 (CYP2C9) with IC50 of 5.8 μM. APD-597 (JNJ-38431055) is developed for treating Type 2 diabetes (T2D).
Targets
hGPR119 [1]
(Cell-free assay)
CYP2C9 [1]
(Cell-free assay)
46 nM(EC50) 5.8 μM

Protocol

Solubility (25°C)

In vitro DMSO 96 mg/mL (200.18 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.55
Formula

C21H29N5O6S

CAS No. 897732-93-3
Storage powder
in solvent
Synonyms JNJ-38431055
Smiles CC1=C(C=CC(=N1)S(=O)(=O)C)NC2=C(C(=NC=N2)OC3CCN(CC3)C(=O)OC(C)C)OC

In vivo Formulation Calculator (Clear solution)

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT00910923 Completed Drug: JNJ-38431055 Diabetes Mellitus Type 2 Johnson & Johnson Pharmaceutical Research & Development L.L.C. November 2008 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID