Name: Albendazole
Brand: Selleck Chemicals
SKU: S1640
Availability: InStock
Rating: 5 (9 reviews)

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Quality Control

Batch: Purity: 99.88%

99.88

Related Targets	Akt Wnt/beta-catenin PKC HSP ROCK Microtubule Associated Integrin Bcr-Abl Actin FAK
Other ADC Cytotoxin Inhibitors	Triptolide SN-38 Luteolin (+)-Bicuculline Rutin Artemisinin BHQ Pinocembrin Luteoloside Psoralen

Solubility

In vitro
Batch:

DMSO : 17 mg/mL (64.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

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%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	265.33	Formula	C₁₂H₁₅N₃O₂S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	54965-21-8	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	SKF-62979			SMILES	CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	tubulin
In vitro	Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. This compound and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle.
In vivo	Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. This compound is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. This benzimidazole derivative has a broad spectrum of activity against human and animal helminthe parasites. It and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. This compound and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs.
References	[1] https://pubmed.ncbi.nlm.nih.gov/2038752/ [2] https://pubmed.ncbi.nlm.nih.gov/16144977/ [3] https://pubmed.ncbi.nlm.nih.gov/2038752/ [4] https://pubmed.ncbi.nlm.nih.gov/12480310/ [5] https://pubmed.ncbi.nlm.nih.gov/10372592/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-05-01)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06565507	NOT_YET_RECRUITING	Brain Cysticercosis	Universidad Peruana Cayetano Heredia	2026-12-01	PHASE2; PHASE3
NCT07707817	RECRUITING	Onchocerciasis (River Blindness); Schistosomiasis; Soil Transmitted Helminth (STH) Infections; Lymphatic Filariasis	Uwemedimo Friday Ekpo	2026-07-01
NCT07159373	NOT_YET_RECRUITING	Lymphatic Filariasis; Scabies; Strongyloidiasis	Medicines Development for Global Health	2026-03	PHASE3
NCT07661316	NOT_YET_RECRUITING	Trichuriasis; Strongyloidiasis; Ascariasis; Hookworm Infection; Soil-Transmitted Helminthiasis	Mundo Sano Foundation	2026-11-01	PHASE3
NCT04713787	RECRUITING	Trichuriasis	Asociacion Benefica Prisma	2024-09-07	PHASE2
NCT07258173	NOT_YET_RECRUITING	Trichuris Infection	Jennifer Keiser	2026-11-15	PHASE2

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Albendazole ADC Cytotoxin inhibitor

Chemical Structure

Molecular Weight: 265.33