Albendazole
Catalog No.S1640 Synonyms: SKF-62979
Molecular Weight(MW): 265.33
Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
Cited by 1 Publication
1 Customer Review
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Dose-dependent disruption in the distribution of α-tubulin following exposure to albendazole. Experimental treatments included vehicle (DMSO), 0.1 μM, 0.5 μM and 1 μM albendazole for 24 hours. α-tubulin was visualized using immunofluorescence (green) and nuclei were stained with DAPI (blue). 40x fluorescence microscopy was used to assess changes in cellular morphology and tubulin distribution.
Oncotarget, 2017, 8(42): 71512-71519. Albendazole purchased from Selleck.
Purity & Quality Control
Choose Selective Microtubule Associated Inhibitors
Biological Activity
| Description | Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. | |
|---|---|---|
| Targets |
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| In vitro |
Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle. [1] |
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| In vivo | Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. [2] Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. [3] Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. [4] Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs. [5] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 17 mg/mL (64.07 mM) |
|---|---|---|
| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 265.33 |
|---|---|
| Formula | C12H15N3O2S |
| CAS No. | 54965-21-8 |
| Storage | powder |
| in solvent | |
| Synonyms | SKF-62979 |
Bio Calculators
Molarity Calculator
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT03527745 | Active not recruiting | Drug: Albendazole|Drug: Placebo | Trichuriasis|Hookworm Infections | Jennifer Keiser|Centre Suisse de Recherches Scientifiques (CSRS)|Swiss Tropical & Public Health Institute | October 23 2018 | Phase 2 |
| NCT03527732 | Recruiting | Drug: Albendazole|Drug: Albendazole and Ivermectin | Trichuriasis | Jennifer Keiser|Centre Suisse de Recherches Scientifiques (CSRS)|Lao Tropical and Public Health Institute|Public Health Laboratory of Pemba Tanzania|Swiss Tropical & Public Health Institute | April 15 2018 | Phase 2|Phase 3 |
| NCT03192449 | Completed | Drug: Albendazole. | Soil Transmitted Helminthiasis|Neglected Tropical Diseases | Universidad Nacional de Salta|CIVETAN CONICET Facultad de Ciencias Veterinarias UNCPBA. Tandil | November 21 2016 | Phase 1 |
Tech Support
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