Albendazole

Catalog No.S1640 Synonyms: SKF-62979

Albendazole Chemical Structure

Molecular Weight(MW): 265.33

Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Cited by 1 Publication

1 Customer Review

  • Dose-dependent disruption in the distribution of α-tubulin following exposure to albendazole. Experimental treatments included vehicle (DMSO), 0.1 μM, 0.5 μM and 1 μM albendazole for 24 hours. α-tubulin was visualized using immunofluorescence (green) and nuclei were stained with DAPI (blue). 40x fluorescence microscopy was used to assess changes in cellular morphology and tubulin distribution.

    Oncotarget, 2017, 8(42): 71512-71519. Albendazole purchased from Selleck.

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Biological Activity

Description Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
Targets
tubulin [1]
In vitro

Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle. [1]

In vivo Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. [2] Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. [3] Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. [4] Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs. [5]

Protocol

Solubility (25°C)

In vitro DMSO 17 mg/mL (64.07 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 265.33
Formula

C12H15N3O2S

CAS No. 54965-21-8
Storage powder
in solvent
Synonyms SKF-62979

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03527745 Active not recruiting Drug: Albendazole|Drug: Placebo Trichuriasis|Hookworm Infections Jennifer Keiser|Centre Suisse de Recherches Scientifiques (CSRS)|Swiss Tropical & Public Health Institute October 23 2018 Phase 2
NCT03527732 Recruiting Drug: Albendazole|Drug: Albendazole and Ivermectin Trichuriasis Jennifer Keiser|Centre Suisse de Recherches Scientifiques (CSRS)|Lao Tropical and Public Health Institute|Public Health Laboratory of Pemba Tanzania|Swiss Tropical & Public Health Institute April 15 2018 Phase 2|Phase 3
NCT03192449 Completed Drug: Albendazole. Soil Transmitted Helminthiasis|Neglected Tropical Diseases Universidad Nacional de Salta|CIVETAN CONICET Facultad de Ciencias Veterinarias UNCPBA. Tandil November 21 2016 Phase 1

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Microtubule Associated Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID