Atropine sulfate monohydrate

Catalog No.S2130

Atropine sulfate monohydrate Chemical Structure

Molecular Weight(MW): 694.83

Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 210 In stock
USD 470 In stock
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Biological Activity

Description Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
Targets
mAChR [1]
2.5 nM
In vitro

Atropine increases the release of the neurotransmitter dopamine into the superfusate in vitro at 100-500 mM and into the vitreous in vivo at 250 mg. Atropine induces spreading depression (SD) in the in vitro preparation. Atropine reduces the ERG b- and d-wave, leads to damped oscillations of RPE potentials, and reverses the ERG c-wave. Atropine suppresses myopia only at doses at which severe nonspecific side effects are observed in the retina. [1]

In vivo Atropine (1.0 mg/kg, i.p.), but not methylatropine (1.0 mg/kg, i.p.), prevents the enhancement of retention induced by both doses of the anticholinesterase when given immediately after training in mice. [2] Atropine administration effectively prevents bradycardia and second-degree heart block but induces pulsus alternans and hypertension in dogs. [3] Atropine has no effect on handling-induced acetylcholine output in the presence of 10 nM neostigmine, but causes greater and longer increases in the presence of 100 nM and 1000 nM neostigmine in rats. [4] Atropine not only blocks the rapid eye movement (REM) sleep increases induced by CGS but it also tends to decrease REM sleep compared to atropine preceding saline in rats. [5] Atropine decreases the time to exhaustion by 67% in intact rats and by 96.2% in adrenodemedullated (ADM) and also reduces the exercise-induced pituitary prolactin (PRL) release in both intact (50%) and ADM rats (90%). [6]

Protocol

Solubility (25°C)

In vitro DMSO 139 mg/mL (200.04 mM)
Water 139 mg/mL (200.04 mM)
Ethanol 139 mg/mL (200.04 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 694.83
Formula

2(C17H23NO3).H2O.H2SO4

CAS No. 5908-99-6
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03865160 Not yet recruiting Myopia Progressive University Eye Hospital Freiburg December 2019 Phase 2|Phase 3
NCT03865160 Not yet recruiting Myopia Progressive University Eye Hospital Freiburg December 2019 Phase 2|Phase 3
NCT03690089 Not yet recruiting Myopia Belfast Health and Social Care Trust February 1 2019 Phase 2
NCT03690089 Not yet recruiting Myopia Belfast Health and Social Care Trust February 1 2019 Phase 2
NCT03754153 Not yet recruiting Amblyopia Moorfields Eye Hospital NHS Foundation Trust January 1 2019 Not Applicable
NCT03754153 Not yet recruiting Amblyopia Moorfields Eye Hospital NHS Foundation Trust January 1 2019 Not Applicable

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID