Atropine sulfate monohydrate

Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.

Atropine sulfate monohydrate Chemical Structure

Atropine sulfate monohydrate Chemical Structure

CAS: 5908-99-6

Selleck's Atropine sulfate monohydrate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.78%
99.78

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Biological Activity

Description Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
Targets
mAChR [1]
2.5 nM
In vitro
In vitro Atropine increases the release of the neurotransmitter dopamine into the superfusate in vitro at 100-500 mM and into the vitreous in vivo at 250 mg. Atropine induces spreading depression (SD) in the in vitro preparation. Atropine reduces the ERG b- and d-wave, leads to damped oscillations of RPE potentials, and reverses the ERG c-wave. Atropine suppresses myopia only at doses at which severe nonspecific side effects are observed in the retina. [1]
In Vivo
In vivo Atropine (1.0 mg/kg, i.p.), but not methylatropine (1.0 mg/kg, i.p.), prevents the enhancement of retention induced by both doses of the anticholinesterase when given immediately after training in mice. [2] Atropine administration effectively prevents bradycardia and second-degree heart block but induces pulsus alternans and hypertension in dogs. [3] Atropine has no effect on handling-induced acetylcholine output in the presence of 10 nM neostigmine, but causes greater and longer increases in the presence of 100 nM and 1000 nM neostigmine in rats. [4] Atropine not only blocks the rapid eye movement (REM) sleep increases induced by CGS but it also tends to decrease REM sleep compared to atropine preceding saline in rats. [5] Atropine decreases the time to exhaustion by 67% in intact rats and by 96.2% in adrenodemedullated (ADM) and also reduces the exercise-induced pituitary prolactin (PRL) release in both intact (50%) and ADM rats (90%). [6]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06102382 Not yet recruiting
Cesarean Section|Hypotension|Norepinephrine
Assiut University
December 10 2023 Not Applicable
NCT06162390 Recruiting
Thyroidectomy
Kyungpook National University Chilgok Hospital
November 20 2023 Not Applicable
NCT06082856 Recruiting
Anesthesia|Dexmedetomidine|Hemodynamics|Ambulatory Care
Centre Hospitalier Universitaire de Nīmes
October 19 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 694.83 Formula

2(C17H23NO3).H2O.H2SO4

CAS No. 5908-99-6 SDF Download Atropine sulfate monohydrate SDF
Smiles CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.O.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 139 mg/mL ( (200.04 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 139 mg/mL

Ethanol : 139 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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