Atropine sulfate monohydrate
For research use only.
CAS No. 5908-99-6
Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
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|Description||Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.|
Atropine increases the release of the neurotransmitter dopamine into the superfusate in vitro at 100-500 mM and into the vitreous in vivo at 250 mg. Atropine induces spreading depression (SD) in the in vitro preparation. Atropine reduces the ERG b- and d-wave, leads to damped oscillations of RPE potentials, and reverses the ERG c-wave. Atropine suppresses myopia only at doses at which severe nonspecific side effects are observed in the retina. 
|In vivo||Atropine (1.0 mg/kg, i.p.), but not methylatropine (1.0 mg/kg, i.p.), prevents the enhancement of retention induced by both doses of the anticholinesterase when given immediately after training in mice.  Atropine administration effectively prevents bradycardia and second-degree heart block but induces pulsus alternans and hypertension in dogs.  Atropine has no effect on handling-induced acetylcholine output in the presence of 10 nM neostigmine, but causes greater and longer increases in the presence of 100 nM and 1000 nM neostigmine in rats.  Atropine not only blocks the rapid eye movement (REM) sleep increases induced by CGS but it also tends to decrease REM sleep compared to atropine preceding saline in rats.  Atropine decreases the time to exhaustion by 67% in intact rats and by 96.2% in adrenodemedullated (ADM) and also reduces the exercise-induced pituitary prolactin (PRL) release in both intact (50%) and ADM rats (90%). |
-  Schwahn HN, et al. Vis Neurosci,?000, 17(2), 165-176.
-  Boccia MM, et al. Neurosci Lett,?003, 345(2), 97-100.
-  Ko JC, et al. J Am Vet Med Assoc,?001, 218(1), 52-58.
|In vitro||DMSO||139 mg/mL (200.04 mM)|
|Water||139 mg/mL (200.04 mM)|
|Ethanol||139 mg/mL (200.04 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03390751||Recruiting||Other: Data collection||Aging||University Hospital Toulouse||December 14 2017||--|
|NCT00947596||Completed||Drug: atropine sulfate||Organophosphorus Poisoning||MicroDose Defense Products L.L.C.|University of Pittsburgh|U.S. Army Space and Missile Defense Command||August 2009||Phase 1|
|NCT00944710||Completed||Drug: Atropine|Device: Plano lens||Amblyopia||Jaeb Center for Health Research|National Eye Institute (NEI)||August 2009||Phase 3|
|NCT00623207||Completed||Drug: Atropine||Chest Pain||HaEmek Medical Center Israel||December 2007||Phase 3|
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