Atropine sulfate monohydrate

Catalog No.S2130

For research use only.

Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.

Atropine sulfate monohydrate Chemical Structure

CAS No. 5908-99-6

Selleck's Atropine sulfate monohydrate has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
mAChR [1]
2.5 nM
In vitro

Atropine increases the release of the neurotransmitter dopamine into the superfusate in vitro at 100-500 mM and into the vitreous in vivo at 250 mg. Atropine induces spreading depression (SD) in the in vitro preparation. Atropine reduces the ERG b- and d-wave, leads to damped oscillations of RPE potentials, and reverses the ERG c-wave. Atropine suppresses myopia only at doses at which severe nonspecific side effects are observed in the retina. [1]

In vivo Atropine (1.0 mg/kg, i.p.), but not methylatropine (1.0 mg/kg, i.p.), prevents the enhancement of retention induced by both doses of the anticholinesterase when given immediately after training in mice. [2] Atropine administration effectively prevents bradycardia and second-degree heart block but induces pulsus alternans and hypertension in dogs. [3] Atropine has no effect on handling-induced acetylcholine output in the presence of 10 nM neostigmine, but causes greater and longer increases in the presence of 100 nM and 1000 nM neostigmine in rats. [4] Atropine not only blocks the rapid eye movement (REM) sleep increases induced by CGS but it also tends to decrease REM sleep compared to atropine preceding saline in rats. [5] Atropine decreases the time to exhaustion by 67% in intact rats and by 96.2% in adrenodemedullated (ADM) and also reduces the exercise-induced pituitary prolactin (PRL) release in both intact (50%) and ADM rats (90%). [6]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 694.83


CAS No. 5908-99-6
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05468125 Not yet recruiting Procedure: guidance Hypotension|Cesarean Section Complications Suez Canal University August 1 2022 Not Applicable
NCT05164367 Recruiting Drug: Atropine sulfate gel (0.01%) Cerebral Palsy|Sialorrhea University of Utah June 1 2022 Early Phase 1
NCT05160207 Recruiting -- Tracheal Intubation|Airway Management|Heart Rate Universitätsklinikum Hamburg-Eppendorf November 4 2021 --
NCT04752904 Recruiting Device: ClearSight System Cesarean Section Complications|Hypotension Seoul National University Hospital April 27 2021 Not Applicable

(data from, updated on 2022-08-01)

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