Anagrelide HCl

Catalog No.S3172 Synonyms: BL-4162A,BMY 26538-01

For research use only.

Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis.

Anagrelide HCl Chemical Structure

CAS No. 58579-51-4

Selleck's Anagrelide HCl has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis.
Targets
PDE [1]
In vitro

Anagrelide is an oral imidazoquinazoline agent with an anti-cyclic AMP phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting the maturation of platelets from megakaryocytes.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 292.55
Formula

C10H7Cl2N3O.HCl

CAS No. 58579-51-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3.Cl

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03866434 Completed Drug: SPD422|Drug: Omeprazole Healthy Volunteers Shire|Takeda February 26 2019 Phase 1
NCT02125318 Completed Drug: Anagrelide CR Thrombocytosis|Myeloproliferative Neoplasms Galena Biopharma Inc. May 2014 Phase 2
NCT01192347 Completed -- Essential Thrombocythemia Shire|Takeda September 13 2010 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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