Home Protein Tyrosine Kinase EGFR inhibitor - HER2 inhibitor - Autophagy activator Afatinib Dimaleate For research use only.

Afatinib Dimaleate

Synonyms: BIBW2992 Dimaleate

Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.

Afatinib Dimaleate Chemical Structure

Afatinib Dimaleate Chemical Structure

CAS No. 850140-73-7

Purity & Quality Control

Afatinib Dimaleate Related Products

Signaling Pathway

EGFR Signaling Pathways

EGFR Signaling Pathway

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCC827 cell Proliferation assay Antiproliferative activity against human HCC827 cells after 96 hrs by MTS assay, IC50=8 nM
NCI-H1563 Growth inhibition assay Inhibition of human NCI-H1563 cell growth in a cell viability assay. IC50=9.76031 μM
NCI-H1573 Growth inhibition assay Inhibition of human NCI-H1573 cell growth in a cell viability assay. IC50=0.7363 μM
NCI-H1581 Growth inhibition assay Inhibition of human NCI-H1581 cell growth in a cell viability assay. IC50=29.3145 μM
NCI-H1648 Growth inhibition assay Inhibition of human NCI-H1648 cell growth in a cell viability assay. IC50=0.44182 μM
NCI-H1793 Growth inhibition assay Inhibition of human NCI-H1793 cell growth in a cell viability assay. IC50=14.2087 μM
NCI-H1838 Growth inhibition assay Inhibition of human NCI-H1838 cell growth in a cell viability assay. IC50=0.60299 μM
NCI-H1770 Growth inhibition assay Inhibition of human NCI-H1770 cell growth in a cell viability assay. IC50=0.1028 μM
NCI-H1651 Growth inhibition assay Inhibition of human NCI-H1651 cell growth in a cell viability assay. IC50=25.597 μM
NCI-H1975 Growth inhibition assay Inhibition of human NCI-H1975 cell growth in a cell viability assay. IC50=0.61728 μM
NCI-H1666 Growth inhibition assay Inhibition of human NCI-H1666 cell growth in a cell viability assay. IC50=1.80948 μM
NCI-H2009 Growth inhibition assay Inhibition of human NCI-H2009 cell growth in a cell viability assay. IC50=3.61216 μM
NCI-H2126 Growth inhibition assay Inhibition of human NCI-H2126 cell growth in a cell viability assay. IC50=0.51926 μM
NCI-H1693 Growth inhibition assay Inhibition of human NCI-H1693 cell growth in a cell viability assay. IC50=3.84181 μM
NCI-H2087 Growth inhibition assay Inhibition of human NCI-H2087 cell growth in a cell viability assay. IC50=49.9682 μM
NCI-H2029 Growth inhibition assay Inhibition of human NCI-H2029 cell growth in a cell viability assay. IC50=43.5581 μM
NCI-H2170 Growth inhibition assay Inhibition of human NCI-H2170 cell growth in a cell viability assay. IC50=0.03728 μM
NCI-H226 Growth inhibition assay Inhibition of human NCI-H226 cell growth in a cell viability assay. IC50=49.7785 μM
NCI-H2030 Growth inhibition assay Inhibition of human NCI-H2030 cell growth in a cell viability assay. IC50=14.6448 μM
NCI-H2052 Growth inhibition assay Inhibition of human NCI-H2052 cell growth in a cell viability assay. IC50=21.8963 μM
NCI-H292 Growth inhibition assay Inhibition of human NCI-H292 cell growth in a cell viability assay. IC50=0.0609 μM
NCI-H441 Growth inhibition assay Inhibition of human NCI-H441 cell growth in a cell viability assay. IC50=3.59841 μM
NCI-H2291 Growth inhibition assay Inhibition of human NCI-H2291 cell growth in a cell viability assay. IC50=5.98943 μM
NCI-H358 Growth inhibition assay Inhibition of human NCI-H358 cell growth in a cell viability assay. IC50=0.5321 μM
NCI-H460 Growth inhibition assay Inhibition of human NCI-H460 cell growth in a cell viability assay. IC50=46.523 μM
NCI-H661 Growth inhibition assay Inhibition of human NCI-H661 cell growth in a cell viability assay. IC50=16.9694 μM
NCI-H23 Growth inhibition assay Inhibition of human NCI-H23 cell growth in a cell viability assay. IC50=37.4196 μM
NCI-H630 Growth inhibition assay Inhibition of human NCI-H630 cell growth in a cell viability assay. IC50=1.45582 μM
NCI-H2342 Growth inhibition assay Inhibition of human NCI-H2342 cell growth in a cell viability assay. IC50=17.557 μM
NCI-H69 Growth inhibition assay Inhibition of human NCI-H69 cell growth in a cell viability assay. IC50=0.21451 μM
NCI-H650 Growth inhibition assay Inhibition of human NCI-H650 cell growth in a cell viability assay. IC50=11.2418 μM
NCI-H747 Growth inhibition assay Inhibition of human NCI-H747 cell growth in a cell viability assay. IC50=5.42472 μM
NCI-H2405 Growth inhibition assay Inhibition of human NCI-H2405 cell growth in a cell viability assay. IC50=17.1974 μM
NCI-H520 Growth inhibition assay Inhibition of human NCI-H520 cell growth in a cell viability assay. IC50=24.8861 μM
NCI-H810 Growth inhibition assay Inhibition of human NCI-H810 cell growth in a cell viability assay. IC50=34.7278 μM
NCI-H720 Growth inhibition assay Inhibition of human NCI-H720 cell growth in a cell viability assay. IC50=0.05325 μM
NCI-SNU-1 Growth inhibition assay Inhibition of human NCI-SNU-1 cell growth in a cell viability assay. IC50=3.69735 μM
NH-12 Growth inhibition assay Inhibition of human NH-12 cell growth in a cell viability assay. IC50=7.72808 μM
NCI-SNU-5 Growth inhibition assay Inhibition of human NCI-SNU-5 cell growth in a cell viability assay. IC50=1.239 μM
NKM-1 Growth inhibition assay Inhibition of human NKM-1 cell growth in a cell viability assay. IC50=3.18744 μM
NCI-H526 Growth inhibition assay Inhibition of human NCI-H526 cell growth in a cell viability assay. IC50=0.07823 μM
NTERA-S-cl-D1 Growth inhibition assay Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay. IC50=5.54537 μM
NMC-G1 Growth inhibition assay Inhibition of human NMC-G1 cell growth in a cell viability assay. IC50=12.9234 μM
NCI-H82 Growth inhibition assay Inhibition of human NCI-H82 cell growth in a cell viability assay. IC50=1.54006 μM
NCI-H1623 Growth inhibition assay Inhibition of human NCI-H1623 cell growth in a cell viability assay. IC50=0.08025 μM
NOMO-1 Growth inhibition assay Inhibition of human NOMO-1 cell growth in a cell viability assay. IC50=34.5703 μM
NCI-N87 Growth inhibition assay Inhibition of human NCI-N87 cell growth in a cell viability assay. IC50=0.02773 μM
NCI-H1650 Growth inhibition assay Inhibition of human NCI-H1650 cell growth in a cell viability assay. IC50=9.60946 μM
NCI-H1703 Growth inhibition assay Inhibition of human NCI-H1703 cell growth in a cell viability assay. IC50=9.34375 μM
NCI-H1755 Growth inhibition assay Inhibition of human NCI-H1755 cell growth in a cell viability assay. IC50=41.8725 μM
NCI-H1993 Growth inhibition assay Inhibition of human NCI-H1993 cell growth in a cell viability assay. IC50=8.33631 μM
NCI-H209 Growth inhibition assay Inhibition of human NCI-H209 cell growth in a cell viability assay. IC50=0.2046 μM
NCI-H2122 Growth inhibition assay Inhibition of human NCI-H2122 cell growth in a cell viability assay. IC50=34.3471 μM
NY Growth inhibition assay Inhibition of human NY cell growth in a cell viability assay. IC50=3.53655 μM
OAW-42 Growth inhibition assay Inhibition of human OAW-42 cell growth in a cell viability assay. IC50=3.50026 μM
OC-314 Growth inhibition assay Inhibition of human OC-314 cell growth in a cell viability assay. IC50=15.4714 μM
NCI-H2228 Growth inhibition assay Inhibition of human NCI-H2228 cell growth in a cell viability assay. IC50=32.6602 μM
OCI-AML2 Growth inhibition assay Inhibition of human OCI-AML2 cell growth in a cell viability assay. IC50=8.95481 μM
OCUB-M Growth inhibition assay Inhibition of human OCUB-M cell growth in a cell viability assay. IC50=3.76187 μM
OE33 Growth inhibition assay Inhibition of human OE33 cell growth in a cell viability assay. IC50=13.786 μM
NCI-H28 Growth inhibition assay Inhibition of human NCI-H28 cell growth in a cell viability assay. IC50=7.16405 μM
OS-RC-2 Growth inhibition assay Inhibition of human OS-RC-2 cell growth in a cell viability assay. IC50=9.0219 μM
ONS-76 Growth inhibition assay Inhibition of human ONS-76 cell growth in a cell viability assay. IC50=41.4709 μM
OVCAR-3 Growth inhibition assay Inhibition of human OVCAR-3 cell growth in a cell viability assay. IC50=2.67167 μM
OVCAR-4 Growth inhibition assay Inhibition of human OVCAR-4 cell growth in a cell viability assay. IC50=10.8835 μM
OVCAR-5 Growth inhibition assay Inhibition of human OVCAR-5 cell growth in a cell viability assay. IC50=13.1593 μM
P12-ICHIKAWA Growth inhibition assay Inhibition of human P12-ICHIKAWA cell growth in a cell viability assay. IC50=25.4785 μM
NCI-H446 Growth inhibition assay Inhibition of human NCI-H446 cell growth in a cell viability assay. IC50=37.4862 μM
NCI-H510A Growth inhibition assay Inhibition of human NCI-H510A cell growth in a cell viability assay. IC50=31.4006 μM
NCI-H596 Growth inhibition assay Inhibition of human NCI-H596 cell growth in a cell viability assay. IC50=12.0369 μM
PA-1 Growth inhibition assay Inhibition of human PA-1 cell growth in a cell viability assay. IC50=49.8335 μM
PC-14 Growth inhibition assay Inhibition of human PC-14 cell growth in a cell viability assay. IC50=0.05668 μM
PANC-03-27 Growth inhibition assay Inhibition of human PANC-03-27 cell growth in a cell viability assay. IC50=2.16631 μM
PANC-08-13 Growth inhibition assay Inhibition of human PANC-08-13 cell growth in a cell viability assay. IC50=1.16416 μM
NCI-H727 Growth inhibition assay Inhibition of human NCI-H727 cell growth in a cell viability assay. IC50=8.1042 μM
RD Growth inhibition assay Inhibition of human RD cell growth in a cell viability assay. IC50=29.5233 μM
QIMR-WIL Growth inhibition assay Inhibition of human QIMR-WIL cell growth in a cell viability assay. IC50=16.7105 μM
RERF-LC-MS Growth inhibition assay Inhibition of human RERF-LC-MS cell growth in a cell viability assay. IC50=17.5508 μM
RCC10RGB Growth inhibition assay Inhibition of human RCC10RGB cell growth in a cell viability assay. IC50=18.0559 μM
RH-18 Growth inhibition assay Inhibition of human RH-18 cell growth in a cell viability assay. IC50=18.0035 μM
RO82-W-1 Growth inhibition assay Inhibition of human RO82-W-1 cell growth in a cell viability assay. IC50=32.1604 μM
RKO Growth inhibition assay Inhibition of human RKO cell growth in a cell viability assay. IC50=14.5075 μM
RPMI-7951 Growth inhibition assay Inhibition of human RPMI-7951 cell growth in a cell viability assay. IC50=3.0759 μM
NEC8 Growth inhibition assay Inhibition of human NEC8 cell growth in a cell viability assay. IC50=14.5472 μM
RPMI-8226 Growth inhibition assay Inhibition of human RPMI-8226 cell growth in a cell viability assay. IC50=4.11631 μM
RS4-11 Growth inhibition assay Inhibition of human RS4-11 cell growth in a cell viability assay. IC50=12.1725 μM
RXF393 Growth inhibition assay Inhibition of human RXF393 cell growth in a cell viability assay. IC50=36.3785 μM
NOS-1 Growth inhibition assay Inhibition of human NOS-1 cell growth in a cell viability assay. IC50=11.711 μM
Ramos-2G6-4C10 Growth inhibition assay Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay. IC50=14.0202 μM
S-117 Growth inhibition assay Inhibition of human S-117 cell growth in a cell viability assay. IC50=36.3008 μM
SCC-25 Growth inhibition assay Inhibition of human SCC-25 cell growth in a cell viability assay. IC50=0.84171 μM
SBC-1 Growth inhibition assay Inhibition of human SBC-1 cell growth in a cell viability assay. IC50=0.18959 μM
SCC-15 Growth inhibition assay Inhibition of human SCC-15 cell growth in a cell viability assay. IC50=1.39451 μM
SCC-4 Growth inhibition assay Inhibition of human SCC-4 cell growth in a cell viability assay. IC50=8.44059 μM
NUGC-3 Growth inhibition assay Inhibition of human NUGC-3 cell growth in a cell viability assay. IC50=0.38373 μM
SCC-9 Growth inhibition assay Inhibition of human SCC-9 cell growth in a cell viability assay. IC50=37.7838 μM
SCH Growth inhibition assay Inhibition of human SCH cell growth in a cell viability assay. IC50=18.6456 μM
OAW-28 Growth inhibition assay Inhibition of human OAW-28 cell growth in a cell viability assay. IC50=7.94578 μM
SF126 Growth inhibition assay Inhibition of human SF126 cell growth in a cell viability assay. IC50=23.6924 μM
SF295 Growth inhibition assay Inhibition of human SF295 cell growth in a cell viability assay. IC50=26.0425 μM
OE19 Growth inhibition assay Inhibition of human OE19 cell growth in a cell viability assay. IC50=1.71512 μM
SF539 Growth inhibition assay Inhibition of human SF539 cell growth in a cell viability assay. IC50=9.23562 μM
SH-4 Growth inhibition assay Inhibition of human SH-4 cell growth in a cell viability assay. IC50=32.1858 μM
SHP-77 Growth inhibition assay Inhibition of human SHP-77 cell growth in a cell viability assay. IC50=29.6182 μM
OMC-1 Growth inhibition assay Inhibition of human OMC-1 cell growth in a cell viability assay. IC50=2.08169 μM
SK-HEP-1 Growth inhibition assay Inhibition of human SK-HEP-1 cell growth in a cell viability assay. IC50=30.6326 μM
SJSA-1 Growth inhibition assay Inhibition of human SJSA-1 cell growth in a cell viability assay. IC50=27.0176 μM
OVCAR-8 Growth inhibition assay Inhibition of human OVCAR-8 cell growth in a cell viability assay. IC50=15.8861 μM
SK-LU-1 Growth inhibition assay Inhibition of human SK-LU-1 cell growth in a cell viability assay. IC50=40.6568 μM
SK-MEL-1 Growth inhibition assay Inhibition of human SK-MEL-1 cell growth in a cell viability assay. IC50=13.7135 μM
SK-MEL-24 Growth inhibition assay Inhibition of human SK-MEL-24 cell growth in a cell viability assay. IC50=11.2366 μM
P30-OHK Growth inhibition assay Inhibition of human P30-OHK cell growth in a cell viability assay. IC50=35.8752 μM
PANC-10-05 Growth inhibition assay Inhibition of human PANC-10-05 cell growth in a cell viability assay. IC50=14.6247 μM
SK-MEL-3 Growth inhibition assay Inhibition of human SK-MEL-3 cell growth in a cell viability assay. IC50=16.4787 μM
SK-MES-1 Growth inhibition assay Inhibition of human SK-MES-1 cell growth in a cell viability assay. IC50=1.11487 μM
PC-3 Growth inhibition assay Inhibition of human PC-3 cell growth in a cell viability assay. IC50=19.9604 μM
SK-NEP-1 Growth inhibition assay Inhibition of human SK-NEP-1 cell growth in a cell viability assay. IC50=1.17513 μM
SK-N-DZ Growth inhibition assay Inhibition of human SK-N-DZ cell growth in a cell viability assay. IC50=28.6885 μM
SK-OV-3 Growth inhibition assay Inhibition of human SK-OV-3 cell growth in a cell viability assay. IC50=8.71329 μM
PFSK-1 Growth inhibition assay Inhibition of human PFSK-1 cell growth in a cell viability assay. IC50=13.06 μM
SK-PN-DW Growth inhibition assay Inhibition of human SK-PN-DW cell growth in a cell viability assay. IC50=35.4369 μM
SK-UT-1 Growth inhibition assay Inhibition of human SK-UT-1 cell growth in a cell viability assay. IC50=13.1083 μM
RCM-1 Growth inhibition assay Inhibition of human RCM-1 cell growth in a cell viability assay. IC50=2.52938 μM
SKG-IIIa Growth inhibition assay Inhibition of human SKG-IIIa cell growth in a cell viability assay. IC50=3.52237 μM
SNU-387 Growth inhibition assay Inhibition of human SNU-387 cell growth in a cell viability assay. IC50=40.4553 μM
SNU-449 Growth inhibition assay Inhibition of human SNU-449 cell growth in a cell viability assay. IC50=3.65826 μM
RMG-I Growth inhibition assay Inhibition of human RMG-I cell growth in a cell viability assay. IC50=7.39296 μM
SNU-C2B Growth inhibition assay Inhibition of human SNU-C2B cell growth in a cell viability assay. IC50=2.68616 μM
RPMI-2650 Growth inhibition assay Inhibition of human RPMI-2650 cell growth in a cell viability assay. IC50=11.5885 μM
SW1116 Growth inhibition assay Inhibition of human SW1116 cell growth in a cell viability assay. IC50=1.01287 μM
SW13 Growth inhibition assay Inhibition of human SW13 cell growth in a cell viability assay. IC50=0.16216 μM
SW1463 Growth inhibition assay Inhibition of human SW1463 cell growth in a cell viability assay. IC50=15.0485 μM
RPMI-8866 Growth inhibition assay Inhibition of human RPMI-8866 cell growth in a cell viability assay. IC50=27.7562 μM
RT-112 Growth inhibition assay Inhibition of human RT-112 cell growth in a cell viability assay. IC50=22.8616 μM
SW1710 Growth inhibition assay Inhibition of human SW1710 cell growth in a cell viability assay. IC50=8.18515 μM
RVH-421 Growth inhibition assay Inhibition of human RVH-421 cell growth in a cell viability assay. IC50=35.7645 μM
SW626 Growth inhibition assay Inhibition of human SW626 cell growth in a cell viability assay. IC50=11.5755 μM
SW1990 Growth inhibition assay Inhibition of human SW1990 cell growth in a cell viability assay. IC50=16.1755 μM
SW756 Growth inhibition assay Inhibition of human SW756 cell growth in a cell viability assay. IC50=6.91176 μM
SW48 Growth inhibition assay Inhibition of human SW48 cell growth in a cell viability assay. IC50=1.25432 μM
SW620 Growth inhibition assay Inhibition of human SW620 cell growth in a cell viability assay. IC50=5.24964 μM
SAS Growth inhibition assay Inhibition of human SAS cell growth in a cell viability assay. IC50=0.48398 μM
SW837 Growth inhibition assay Inhibition of human SW837 cell growth in a cell viability assay. IC50=12.9028 μM
SW872 Growth inhibition assay Inhibition of human SW872 cell growth in a cell viability assay. IC50=42.6331 μM
SW900 Growth inhibition assay Inhibition of human SW900 cell growth in a cell viability assay. IC50=7.82121 μM
SW948 Growth inhibition assay Inhibition of human SW948 cell growth in a cell viability assay. IC50=46.4462 μM
SiHa Growth inhibition assay Inhibition of human SiHa cell growth in a cell viability assay. IC50=23.9327 μM
SW962 Growth inhibition assay Inhibition of human SW962 cell growth in a cell viability assay. IC50=5.62032 μM
T-24 Growth inhibition assay Inhibition of human T-24 cell growth in a cell viability assay. IC50=34.0205 μM
Saos-2 Growth inhibition assay Inhibition of human Saos-2 cell growth in a cell viability assay. IC50=19.1162 μM
T47D Growth inhibition assay Inhibition of human T47D cell growth in a cell viability assay. IC50=3.62217 μM
T98G Growth inhibition assay Inhibition of human T98G cell growth in a cell viability assay. IC50=27.5846 μM
T84 Growth inhibition assay Inhibition of human T84 cell growth in a cell viability assay. IC50=11.3907 μM
SF268 Growth inhibition assay Inhibition of human SF268 cell growth in a cell viability assay. IC50=29.5932 μM
22RV1 Growth inhibition assay Inhibition of human 22RV1 cell growth in a cell viability assay. IC50=34.1754 μM
TE-1 Growth inhibition assay Inhibition of human TE-1 cell growth in a cell viability assay. IC50=1.81475 μM
23132-87 Growth inhibition assay Inhibition of human 23132-87 cell growth in a cell viability assay. IC50=0.31923 μM
SJRH30 Growth inhibition assay Inhibition of human SJRH30 cell growth in a cell viability assay. IC50=30.2108 μM
5637 Growth inhibition assay Inhibition of human 5637 cell growth in a cell viability assay. IC50=1.0151 μM
647-V Growth inhibition assay Inhibition of human 647-V cell growth in a cell viability assay. IC50=3.98452 μM
639-V Growth inhibition assay Inhibition of human 639-V cell growth in a cell viability assay. IC50=31.5243 μM
769-P Growth inhibition assay Inhibition of human 769-P cell growth in a cell viability assay. IC50=2.29037 μM
8-MG-BA Growth inhibition assay Inhibition of human 8-MG-BA cell growth in a cell viability assay. IC50=36.9483 μM
8305C Growth inhibition assay Inhibition of human 8305C cell growth in a cell viability assay. IC50=3.75911 μM
SK-MEL-2 Growth inhibition assay Inhibition of human SK-MEL-2 cell growth in a cell viability assay. IC50=32.6527 μM
8505C Growth inhibition assay Inhibition of human 8505C cell growth in a cell viability assay. IC50=13.2067 μM
A204 Growth inhibition assay Inhibition of human A204 cell growth in a cell viability assay. IC50=32.5069 μM
A101D Growth inhibition assay Inhibition of human A101D cell growth in a cell viability assay. IC50=49.9425 μM
SK-MEL-28 Growth inhibition assay Inhibition of human SK-MEL-28 cell growth in a cell viability assay. IC50=19.3363 μM
SK-N-AS Growth inhibition assay Inhibition of human SK-N-AS cell growth in a cell viability assay. IC50=21.8275 μM
A2780 Growth inhibition assay Inhibition of human A2780 cell growth in a cell viability assay. IC50=2.06294 μM
A3-KAW Growth inhibition assay Inhibition of human A3-KAW cell growth in a cell viability assay. IC50=23.1003 μM
A4-Fuk Growth inhibition assay Inhibition of human A4-Fuk cell growth in a cell viability assay. IC50=22.1419 μM
A431 Growth inhibition assay Inhibition of human A431 cell growth in a cell viability assay. IC50=0.48233 μM
A388 Growth inhibition assay Inhibition of human A388 cell growth in a cell viability assay. IC50=0.36857 μM
SK-N-FI Growth inhibition assay Inhibition of human SK-N-FI cell growth in a cell viability assay. IC50=28.433 μM
A549 Growth inhibition assay Inhibition of human A549 cell growth in a cell viability assay. IC50=6.12553 μM
A673 Growth inhibition assay Inhibition of human A673 cell growth in a cell viability assay. IC50=41.5157 μM
ACN Growth inhibition assay Inhibition of human ACN cell growth in a cell viability assay. IC50=0.55094 μM
A704 Growth inhibition assay Inhibition of human A704 cell growth in a cell viability assay. IC50=18.4753 μM
SN12C Growth inhibition assay Inhibition of human SN12C cell growth in a cell viability assay. IC50=2.91964 μM
ALL-PO Growth inhibition assay Inhibition of human ALL-PO cell growth in a cell viability assay. IC50=11.2512 μM
ABC-1 Growth inhibition assay Inhibition of human ABC-1 cell growth in a cell viability assay. IC50=34.3693 μM
ACHN Growth inhibition assay Inhibition of human ACHN cell growth in a cell viability assay. IC50=0.31994 μM
AN3-CA Growth inhibition assay Inhibition of human AN3-CA cell growth in a cell viability assay. IC50=28.4395 μM
ATN-1 Growth inhibition assay Inhibition of human ATN-1 cell growth in a cell viability assay. IC50=33.1416 μM
AU565 Growth inhibition assay Inhibition of human AU565 cell growth in a cell viability assay. IC50=0.08504 μM
BALL-1 Growth inhibition assay Inhibition of human BALL-1 cell growth in a cell viability assay. IC50=9.21907 μM
BB65-RCC Growth inhibition assay Inhibition of human BB65-RCC cell growth in a cell viability assay. IC50=0.34593 μM
BB49-HNC Growth inhibition assay Inhibition of human BB49-HNC cell growth in a cell viability assay. IC50=43.2356 μM
SW1417 Growth inhibition assay Inhibition of human SW1417 cell growth in a cell viability assay. IC50=4.12147 μM
BHY Growth inhibition assay Inhibition of human BHY cell growth in a cell viability assay. IC50=0.28655 μM
BCPAP Growth inhibition assay Inhibition of human BCPAP cell growth in a cell viability assay. IC50=27.137 μM
BFTC-905 Growth inhibition assay Inhibition of human BFTC-905 cell growth in a cell viability assay. IC50=29.2706 μM
BE-13 Growth inhibition assay Inhibition of human BE-13 cell growth in a cell viability assay. IC50=7.98112 μM
BHT-101 Growth inhibition assay Inhibition of human BHT-101 cell growth in a cell viability assay. IC50=14.241 μM
SW1573 Growth inhibition assay Inhibition of human SW1573 cell growth in a cell viability assay. IC50=11.7294 μM
SW684 Growth inhibition assay Inhibition of human SW684 cell growth in a cell viability assay. IC50=19.1326 μM
BPH-1 Growth inhibition assay Inhibition of human BPH-1 cell growth in a cell viability assay. IC50=0.05988 μM
SW780 Growth inhibition assay Inhibition of human SW780 cell growth in a cell viability assay. IC50=25.3264 μM
BT-474 Growth inhibition assay Inhibition of human BT-474 cell growth in a cell viability assay. IC50=0.04986 μM
SW954 Growth inhibition assay Inhibition of human SW954 cell growth in a cell viability assay. IC50=1.20214 μM
C2BBe1 Growth inhibition assay Inhibition of human C2BBe1 cell growth in a cell viability assay. IC50=14.764 μM
BV-173 Growth inhibition assay Inhibition of human BV-173 cell growth in a cell viability assay. IC50=0.17596 μM
SW982 Growth inhibition assay Inhibition of human SW982 cell growth in a cell viability assay. IC50=18.2671 μM
Becker Growth inhibition assay Inhibition of human Becker cell growth in a cell viability assay. IC50=20.7201 μM
BxPC-3 Growth inhibition assay Inhibition of human BxPC-3 cell growth in a cell viability assay. IC50=10.0973 μM
C8166 Growth inhibition assay Inhibition of human C8166 cell growth in a cell viability assay. IC50=33.8854 μM
C-33-A Growth inhibition assay Inhibition of human C-33-A cell growth in a cell viability assay. IC50=0.81297 μM
C3A Growth inhibition assay Inhibition of human C3A cell growth in a cell viability assay. IC50=30.2927 μM
CAKI-1 Growth inhibition assay Inhibition of human CAKI-1 cell growth in a cell viability assay. IC50=1.78211 μM
TCCSUP Growth inhibition assay Inhibition of human TCCSUP cell growth in a cell viability assay. IC50=28.6418 μM
CAL-120 Growth inhibition assay Inhibition of human CAL-120 cell growth in a cell viability assay. IC50=15.1447 μM
CAL-12T Growth inhibition assay Inhibition of human CAL-12T cell growth in a cell viability assay. IC50=1.88945 μM
CAL-27 Growth inhibition assay Inhibition of human CAL-27 cell growth in a cell viability assay. IC50=0.17636 μM
CAL-51 Growth inhibition assay Inhibition of human CAL-51 cell growth in a cell viability assay. IC50=31.5667 μM
CAL-39 Growth inhibition assay Inhibition of human CAL-39 cell growth in a cell viability assay. IC50=0.11792 μM
CAL-54 Growth inhibition assay Inhibition of human CAL-54 cell growth in a cell viability assay. IC50=0.61621 μM
697 Growth inhibition assay Inhibition of human 697 cell growth in a cell viability assay. IC50=28.6331 μM
CAL-85-1 Growth inhibition assay Inhibition of human CAL-85-1 cell growth in a cell viability assay. IC50=9.87383 μM
CAL-62 Growth inhibition assay Inhibition of human CAL-62 cell growth in a cell viability assay. IC50=43.4028 μM
CAL-72 Growth inhibition assay Inhibition of human CAL-72 cell growth in a cell viability assay. IC50=10.9391 μM
786-0 Growth inhibition assay Inhibition of human 786-0 cell growth in a cell viability assay. IC50=3.06408 μM
TE-11 Growth inhibition assay Inhibition of human TE-11 cell growth in a cell viability assay. IC50=26.7752 μM
A172 Growth inhibition assay Inhibition of human A172 cell growth in a cell viability assay. IC50=12.0798 μM
TE-5 Growth inhibition assay Inhibition of human TE-5 cell growth in a cell viability assay. IC50=5.4085 μM
TE-6 Growth inhibition assay Inhibition of human TE-6 cell growth in a cell viability assay. IC50=0.40246 μM
TE-9 Growth inhibition assay Inhibition of human TE-9 cell growth in a cell viability assay. IC50=3.84382 μM
TGBC24TKB Growth inhibition assay Inhibition of human TGBC24TKB cell growth in a cell viability assay. IC50=1.6823 μM
A2058 Growth inhibition assay Inhibition of human A2058 cell growth in a cell viability assay. IC50=15.0409 μM
TI-73 Growth inhibition assay Inhibition of human TI-73 cell growth in a cell viability assay. IC50=0.14715 μM
A427 Growth inhibition assay Inhibition of human A427 cell growth in a cell viability assay. IC50=37.9107 μM
TK10 Growth inhibition assay Inhibition of human TK10 cell growth in a cell viability assay. IC50=0.26738 μM
TGBC1TKB Growth inhibition assay Inhibition of human TGBC1TKB cell growth in a cell viability assay. IC50=30.1238 μM
A498 Growth inhibition assay Inhibition of human A498 cell growth in a cell viability assay. IC50=0.40674 μM
AGS Growth inhibition assay Inhibition of human AGS cell growth in a cell viability assay. IC50=0.83648 μM
U-2-OS Growth inhibition assay Inhibition of human U-2-OS cell growth in a cell viability assay. IC50=17.5307 μM
U-118-MG Growth inhibition assay Inhibition of human U-118-MG cell growth in a cell viability assay. IC50=36.8847 μM
U-266 Growth inhibition assay Inhibition of human U-266 cell growth in a cell viability assay. IC50=16.2299 μM
U031 Growth inhibition assay Inhibition of human U031 cell growth in a cell viability assay. IC50=5.25424 μM
UACC-257 Growth inhibition assay Inhibition of human UACC-257 cell growth in a cell viability assay. IC50=41.7369 μM
U-87-MG Growth inhibition assay Inhibition of human U-87-MG cell growth in a cell viability assay. IC50=4.10481 μM
AsPC-1 Growth inhibition assay Inhibition of human AsPC-1 cell growth in a cell viability assay. IC50=19.6471 μM
UACC-893 Growth inhibition assay Inhibition of human UACC-893 cell growth in a cell viability assay. IC50=0.11885 μM
BB30-HNC Growth inhibition assay Inhibition of human BB30-HNC cell growth in a cell viability assay. IC50=0.16576 μM
UM-UC-3 Growth inhibition assay Inhibition of human UM-UC-3 cell growth in a cell viability assay. IC50=9.9503 μM
VM-CUB-1 Growth inhibition assay Inhibition of human VM-CUB-1 cell growth in a cell viability assay. IC50=4.86819 μM
UMC-11 Growth inhibition assay Inhibition of human UMC-11 cell growth in a cell viability assay. IC50=26.4514 μM
BEN Growth inhibition assay Inhibition of human BEN cell growth in a cell viability assay. IC50=27.8517 μM
WM-115 Growth inhibition assay Inhibition of human WM-115 cell growth in a cell viability assay. IC50=11.7588 μM
BFTC-909 Growth inhibition assay Inhibition of human BFTC-909 cell growth in a cell viability assay. IC50=9.06799 μM
YAPC Growth inhibition assay Inhibition of human YAPC cell growth in a cell viability assay. IC50=11.9259 μM
BT-20 Growth inhibition assay Inhibition of human BT-20 cell growth in a cell viability assay. IC50=3.69795 μM
YKG-1 Growth inhibition assay Inhibition of human YKG-1 cell growth in a cell viability assay. IC50=1.05419 μM
CAPAN-1 Growth inhibition assay Inhibition of human CAPAN-1 cell growth in a cell viability assay. IC50=30.5181 μM
no-10 Growth inhibition assay Inhibition of human no-10 cell growth in a cell viability assay. IC50=16.6343 μM
CAMA-1 Growth inhibition assay Inhibition of human CAMA-1 cell growth in a cell viability assay. IC50=9.28128 μM
CAS-1 Growth inhibition assay Inhibition of human CAS-1 cell growth in a cell viability assay. IC50=46.7701 μM
BT-549 Growth inhibition assay Inhibition of human BT-549 cell growth in a cell viability assay. IC50=6.66889 μM
CCRF-CEM Growth inhibition assay Inhibition of human CCRF-CEM cell growth in a cell viability assay. IC50=25.967 μM
CGTH-W-1 Growth inhibition assay Inhibition of human CGTH-W-1 cell growth in a cell viability assay. IC50=42.4955 μM
CHP-212 Growth inhibition assay Inhibition of human CHP-212 cell growth in a cell viability assay. IC50=22.3222 μM
C32 Growth inhibition assay Inhibition of human C32 cell growth in a cell viability assay. IC50=9.33064 μM
COLO-320-HSR Growth inhibition assay Inhibition of human COLO-320-HSR cell growth in a cell viability assay. IC50=18.746 μM
CAL-33 Growth inhibition assay Inhibition of human CAL-33 cell growth in a cell viability assay. IC50=0.20184 μM
COLO-678 Growth inhibition assay Inhibition of human COLO-678 cell growth in a cell viability assay. IC50=0.80834 μM
COLO-680N Growth inhibition assay Inhibition of human COLO-680N cell growth in a cell viability assay. IC50=44.339 μM
COLO-684 Growth inhibition assay Inhibition of human COLO-684 cell growth in a cell viability assay. IC50=16.9477 μM
TE-10 Growth inhibition assay Inhibition of human TE-10 cell growth in a cell viability assay. IC50=2.68078 μM
COLO-741 Growth inhibition assay Inhibition of human COLO-741 cell growth in a cell viability assay. IC50=20.66 μM
COLO-792 Growth inhibition assay Inhibition of human COLO-792 cell growth in a cell viability assay. IC50=25.2732 μM
TE-12 Growth inhibition assay Inhibition of human TE-12 cell growth in a cell viability assay. IC50=1.80414 μM
COR-L23 Growth inhibition assay Inhibition of human COR-L23 cell growth in a cell viability assay. IC50=24.1767 μM
COLO-824 Growth inhibition assay Inhibition of human COLO-824 cell growth in a cell viability assay. IC50=15.1579 μM
COR-L105 Growth inhibition assay Inhibition of human COR-L105 cell growth in a cell viability assay. IC50=0.21084 μM
COR-L88 Growth inhibition assay Inhibition of human COR-L88 cell growth in a cell viability assay. IC50=0.64113 μM
TE-8 Growth inhibition assay Inhibition of human TE-8 cell growth in a cell viability assay. IC50=1.91377 μM
TGBC11TKB Growth inhibition assay Inhibition of human TGBC11TKB cell growth in a cell viability assay. IC50=47.1777 μM
CP50-MEL-B Growth inhibition assay Inhibition of human CP50-MEL-B cell growth in a cell viability assay. IC50=17.0343 μM
CP66-MEL Growth inhibition assay Inhibition of human CP66-MEL cell growth in a cell viability assay. IC50=15.4688 μM
CTB-1 Growth inhibition assay Inhibition of human CTB-1 cell growth in a cell viability assay. IC50=4.8488 μM
CaR-1 Growth inhibition assay Inhibition of human CaR-1 cell growth in a cell viability assay. IC50=2.28281 μM
CTV-1 Growth inhibition assay Inhibition of human CTV-1 cell growth in a cell viability assay. IC50=0.64392 μM
CW-2 Growth inhibition assay Inhibition of human CW-2 cell growth in a cell viability assay. IC50=0.46914 μM
Ca-Ski Growth inhibition assay Inhibition of human Ca-Ski cell growth in a cell viability assay. IC50=7.64259 μM
U251 Growth inhibition assay Inhibition of human U251 cell growth in a cell viability assay. IC50=40.4054 μM
Ca9-22 Growth inhibition assay Inhibition of human Ca9-22 cell growth in a cell viability assay. IC50=0.08353 μM
Calu-3 Growth inhibition assay Inhibition of human Calu-3 cell growth in a cell viability assay. IC50=0.81434 μM
Capan-2 Growth inhibition assay Inhibition of human Capan-2 cell growth in a cell viability assay. IC50=3.46875 μM
UACC-62 Growth inhibition assay Inhibition of human UACC-62 cell growth in a cell viability assay. IC50=11.2368 μM
ChaGo-K-1 Growth inhibition assay Inhibition of human ChaGo-K-1 cell growth in a cell viability assay. IC50=32.007 μM
VA-ES-BJ Growth inhibition assay Inhibition of human VA-ES-BJ cell growth in a cell viability assay. IC50=35.4648 μM
D-263MG Growth inhibition assay Inhibition of human D-263MG cell growth in a cell viability assay. IC50=33.8378 μM
VMRC-RCZ Growth inhibition assay Inhibition of human VMRC-RCZ cell growth in a cell viability assay. IC50=8.01697 μM
D-336MG Growth inhibition assay Inhibition of human D-336MG cell growth in a cell viability assay. IC50=30.2892 μM
D-392MG Growth inhibition assay Inhibition of human D-392MG cell growth in a cell viability assay. IC50=35.0565 μM
D-566MG Growth inhibition assay Inhibition of human D-566MG cell growth in a cell viability assay. IC50=29.9393 μM
D-423MG Growth inhibition assay Inhibition of human D-423MG cell growth in a cell viability assay. IC50=5.61705 μM
DBTRG-05MG Growth inhibition assay Inhibition of human DBTRG-05MG cell growth in a cell viability assay. IC50=13.0633 μM
D-502MG Growth inhibition assay Inhibition of human D-502MG cell growth in a cell viability assay. IC50=8.29282 μM
ZR-75-30 Growth inhibition assay Inhibition of human ZR-75-30 cell growth in a cell viability assay. IC50=0.09545 μM
D-542MG Growth inhibition assay Inhibition of human D-542MG cell growth in a cell viability assay. IC50=1.01064 μM
DMS-273 Growth inhibition assay Inhibition of human DMS-273 cell growth in a cell viability assay. IC50=32.5322 μM
DJM-1 Growth inhibition assay Inhibition of human DJM-1 cell growth in a cell viability assay. IC50=6.92012 μM
DK-MG Growth inhibition assay Inhibition of human DK-MG cell growth in a cell viability assay. IC50=30.5456 μM
no-11 Growth inhibition assay Inhibition of human no-11 cell growth in a cell viability assay. IC50=3.53564 μM
DMS-114 Growth inhibition assay Inhibition of human DMS-114 cell growth in a cell viability assay. IC50=40.8374 μM
DMS-79 Growth inhibition assay Inhibition of human DMS-79 cell growth in a cell viability assay. IC50=40.5889 μM
DOK Growth inhibition assay Inhibition of human DOK cell growth in a cell viability assay. IC50=0.03194 μM
CFPAC-1 Growth inhibition assay Inhibition of human CFPAC-1 cell growth in a cell viability assay. IC50=1.42493 μM
DSH1 Growth inhibition assay Inhibition of human DSH1 cell growth in a cell viability assay. IC50=0.03314 μM
DU-145 Growth inhibition assay Inhibition of human DU-145 cell growth in a cell viability assay. IC50=0.44833 μM
CHL-1 Growth inhibition assay Inhibition of human CHL-1 cell growth in a cell viability assay. IC50=0.01839 μM
DU-4475 Growth inhibition assay Inhibition of human DU-4475 cell growth in a cell viability assay. IC50=1.40121 μM
DoTc2-4510 Growth inhibition assay Inhibition of human DoTc2-4510 cell growth in a cell viability assay. IC50=0.32219 μM
Daoy Growth inhibition assay Inhibition of human Daoy cell growth in a cell viability assay. IC50=24.126 μM
Detroit562 Growth inhibition assay Inhibition of human Detroit562 cell growth in a cell viability assay. IC50=1.70152 μM
ECC10 Growth inhibition assay Inhibition of human ECC10 cell growth in a cell viability assay. IC50=1.55369 μM
EC-GI-10 Growth inhibition assay Inhibition of human EC-GI-10 cell growth in a cell viability assay. IC50=0.05912 μM
EFM-19 Growth inhibition assay Inhibition of human EFM-19 cell growth in a cell viability assay. IC50=37.7967 μM
COLO-679 Growth inhibition assay Inhibition of human COLO-679 cell growth in a cell viability assay. IC50=35.388 μM
EFO-21 Growth inhibition assay Inhibition of human EFO-21 cell growth in a cell viability assay. IC50=11.1045 μM
EFO-27 Growth inhibition assay Inhibition of human EFO-27 cell growth in a cell viability assay. IC50=0.05182 μM
EKVX Growth inhibition assay Inhibition of human EKVX cell growth in a cell viability assay. IC50=1.01064 μM
EGI-1 Growth inhibition assay Inhibition of human EGI-1 cell growth in a cell viability assay. IC50=28.5928 μM
EPLC-272H Growth inhibition assay Inhibition of human EPLC-272H cell growth in a cell viability assay. IC50=4.41533 μM
COLO-800 Growth inhibition assay Inhibition of human COLO-800 cell growth in a cell viability assay. IC50=7.41446 μM
COLO-829 Growth inhibition assay Inhibition of human COLO-829 cell growth in a cell viability assay. IC50=8.80976 μM
ES3 Growth inhibition assay Inhibition of human ES3 cell growth in a cell viability assay. IC50=16.9134 μM
ES8 Growth inhibition assay Inhibition of human ES8 cell growth in a cell viability assay. IC50=17.6087 μM
ES4 Growth inhibition assay Inhibition of human ES4 cell growth in a cell viability assay. IC50=0.97836 μM
ETK-1 Growth inhibition assay Inhibition of human ETK-1 cell growth in a cell viability assay. IC50=1.37456 μM
EW-1 Growth inhibition assay Inhibition of human EW-1 cell growth in a cell viability assay. IC50=45.9689 μM
ES5 Growth inhibition assay Inhibition of human ES5 cell growth in a cell viability assay. IC50=4.83723 μM
EW-11 Growth inhibition assay Inhibition of human EW-11 cell growth in a cell viability assay. IC50=9.17653 μM
EW-13 Growth inhibition assay Inhibition of human EW-13 cell growth in a cell viability assay. IC50=14.0352 μM
EW-18 Growth inhibition assay Inhibition of human EW-18 cell growth in a cell viability assay. IC50=0.68698 μM
EW-3 Growth inhibition assay Inhibition of human EW-3 cell growth in a cell viability assay. IC50=1.07883 μM
EW-24 Growth inhibition assay Inhibition of human EW-24 cell growth in a cell viability assay. IC50=21.3945 μM
Calu-6 Growth inhibition assay Inhibition of human Calu-6 cell growth in a cell viability assay. IC50=30.2963 μM
FTC-133 Growth inhibition assay Inhibition of human FTC-133 cell growth in a cell viability assay. IC50=11.1407 μM
EoL-1-cell Growth inhibition assay Inhibition of human EoL-1-cell cell growth in a cell viability assay. IC50=0.26892 μM
FADU Growth inhibition assay Inhibition of human FADU cell growth in a cell viability assay. IC50=0.54404 μM
G-401 Growth inhibition assay Inhibition of human G-401 cell growth in a cell viability assay. IC50=1.67413 μM
GAK Growth inhibition assay Inhibition of human GAK cell growth in a cell viability assay. IC50=25.2963 μM
GAMG Growth inhibition assay Inhibition of human GAMG cell growth in a cell viability assay. IC50=3.91314 μM
GMS-10 Growth inhibition assay Inhibition of human GMS-10 cell growth in a cell viability assay. IC50=2.03517 μM
GB-1 Growth inhibition assay Inhibition of human GB-1 cell growth in a cell viability assay. IC50=25.4068 μM
GI-ME-N Growth inhibition assay Inhibition of human GI-ME-N cell growth in a cell viability assay. IC50=31.0571 μM
GOTO Growth inhibition assay Inhibition of human GOTO cell growth in a cell viability assay. IC50=31.8506 μM
GCIY Growth inhibition assay Inhibition of human GCIY cell growth in a cell viability assay. IC50=1.08104 μM
GT3TKB Growth inhibition assay Inhibition of human GT3TKB cell growth in a cell viability assay. IC50=8.67964 μM
GP5d Growth inhibition assay Inhibition of human GP5d cell growth in a cell viability assay. IC50=6.97394 μM
D-283MED Growth inhibition assay Inhibition of human D-283MED cell growth in a cell viability assay. IC50=18.0088 μM
GR-ST Growth inhibition assay Inhibition of human GR-ST cell growth in a cell viability assay. IC50=28.6696 μM
DB Growth inhibition assay Inhibition of human DB cell growth in a cell viability assay. IC50=7.61005 μM
HC-1 Growth inhibition assay Inhibition of human HC-1 cell growth in a cell viability assay. IC50=5.51839 μM
HAL-01 Growth inhibition assay Inhibition of human HAL-01 cell growth in a cell viability assay. IC50=8.5191 μM
HCC1187 Growth inhibition assay Inhibition of human HCC1187 cell growth in a cell viability assay. IC50=20.6734 μM
HCC1419 Growth inhibition assay Inhibition of human HCC1419 cell growth in a cell viability assay. IC50=0.36408 μM
HCC1395 Growth inhibition assay Inhibition of human HCC1395 cell growth in a cell viability assay. IC50=14.9338 μM
DEL Growth inhibition assay Inhibition of human DEL cell growth in a cell viability assay. IC50=10.3946 μM
DOHH-2 Growth inhibition assay Inhibition of human DOHH-2 cell growth in a cell viability assay. IC50=20.5463 μM
HCC1937 Growth inhibition assay Inhibition of human HCC1937 cell growth in a cell viability assay. IC50=12.7564 μM
HCC38 Growth inhibition assay Inhibition of human HCC38 cell growth in a cell viability assay. IC50=42.9618 μM
HCC1954 Growth inhibition assay Inhibition of human HCC1954 cell growth in a cell viability assay. IC50=11.0754 μM
HCC2218 Growth inhibition assay Inhibition of human HCC2218 cell growth in a cell viability assay. IC50=0.009869 μM
HCE-4 Growth inhibition assay Inhibition of human HCE-4 cell growth in a cell viability assay. IC50=9.21558 μM
HCE-T Growth inhibition assay Inhibition of human HCE-T cell growth in a cell viability assay. IC50=0.88428 μM
HL-60 Growth inhibition assay Inhibition of human HL-60 cell growth in a cell viability assay. IC50=4.86611 μM
HCT-116 Growth inhibition assay Inhibition of human HCT-116 cell growth in a cell viability assay. IC50=4.41007 μM
HEL Growth inhibition assay Inhibition of human HEL cell growth in a cell viability assay. IC50=7.71203 μM
HCT-15 Growth inhibition assay Inhibition of human HCT-15 cell growth in a cell viability assay. IC50=22.7441 μM
HLE Growth inhibition assay Inhibition of human HLE cell growth in a cell viability assay. IC50=0.35046 μM
HH Growth inhibition assay Inhibition of human HH cell growth in a cell viability assay. IC50=16.5162 μM
HD-MY-Z Growth inhibition assay Inhibition of human HD-MY-Z cell growth in a cell viability assay. IC50=48.786 μM
HO-1-N-1 Growth inhibition assay Inhibition of human HO-1-N-1 cell growth in a cell viability assay. IC50=0.27853 μM
HN Growth inhibition assay Inhibition of human HN cell growth in a cell viability assay. IC50=0.13077 μM
HDLM-2 Growth inhibition assay Inhibition of human HDLM-2 cell growth in a cell viability assay. IC50=0.00572 μM
EM-2 Growth inhibition assay Inhibition of human EM-2 cell growth in a cell viability assay. IC50=14.8576 μM
HOP-92 Growth inhibition assay Inhibition of human HOP-92 cell growth in a cell viability assay. IC50=26.1226 μM
HPAF-II Growth inhibition assay Inhibition of human HPAF-II cell growth in a cell viability assay. IC50=41.6709 μM
HSC-2 Growth inhibition assay Inhibition of human HSC-2 cell growth in a cell viability assay. IC50=0.16837 μM
ES1 Growth inhibition assay Inhibition of human ES1 cell growth in a cell viability assay. IC50=19.9213 μM
HSC-3 Growth inhibition assay Inhibition of human HSC-3 cell growth in a cell viability assay. IC50=0.21198 μM
HSC-4 Growth inhibition assay Inhibition of human HSC-4 cell growth in a cell viability assay. IC50=0.01748 μM
ES7 Growth inhibition assay Inhibition of human ES7 cell growth in a cell viability assay. IC50=19.6292 μM
HT-144 Growth inhibition assay Inhibition of human HT-144 cell growth in a cell viability assay. IC50=27.4032 μM
ESS-1 Growth inhibition assay Inhibition of human ESS-1 cell growth in a cell viability assay. IC50=18.5206 μM
HT-29 Growth inhibition assay Inhibition of human HT-29 cell growth in a cell viability assay. IC50=3.07309 μM
HT-3 Growth inhibition assay Inhibition of human HT-3 cell growth in a cell viability assay. IC50=1.28753 μM
HT55 Growth inhibition assay Inhibition of human HT55 cell growth in a cell viability assay. IC50=2.5738 μM
EW-16 Growth inhibition assay Inhibition of human EW-16 cell growth in a cell viability assay. IC50=27.2947 μM
HTC-C3 Growth inhibition assay Inhibition of human HTC-C3 cell growth in a cell viability assay. IC50=27.2561 μM
HT-1376 Growth inhibition assay Inhibition of human HT-1376 cell growth in a cell viability assay. IC50=1.01513 μM
EW-22 Growth inhibition assay Inhibition of human EW-22 cell growth in a cell viability assay. IC50=41.8697 μM
Hs-578-T Growth inhibition assay Inhibition of human Hs-578-T cell growth in a cell viability assay. IC50=45.0294 μM
G-361 Growth inhibition assay Inhibition of human G-361 cell growth in a cell viability assay. IC50=26.1027 μM
HuH-7 Growth inhibition assay Inhibition of human HuH-7 cell growth in a cell viability assay. IC50=28.4028 μM
HuO-3N1 Growth inhibition assay Inhibition of human HuO-3N1 cell growth in a cell viability assay. IC50=5.24043 μM
HuO9 Growth inhibition assay Inhibition of human HuO9 cell growth in a cell viability assay. IC50=11.8774 μM
G-402 Growth inhibition assay Inhibition of human G-402 cell growth in a cell viability assay. IC50=35.9867 μM
IGROV-1 Growth inhibition assay Inhibition of human IGROV-1 cell growth in a cell viability assay. IC50=0.25952 μM
HuP-T3 Growth inhibition assay Inhibition of human HuP-T3 cell growth in a cell viability assay. IC50=16.6576 μM
HuP-T4 Growth inhibition assay Inhibition of human HuP-T4 cell growth in a cell viability assay. IC50=0.6976 μM
GCT Growth inhibition assay Inhibition of human GCT cell growth in a cell viability assay. IC50=20.3026 μM
IST-MEL1 Growth inhibition assay Inhibition of human IST-MEL1 cell growth in a cell viability assay. IC50=11.456 μM
GI-1 Growth inhibition assay Inhibition of human GI-1 cell growth in a cell viability assay. IC50=22.7658 μM
IST-MES1 Growth inhibition assay Inhibition of human IST-MES1 cell growth in a cell viability assay. IC50=18.4428 μM
J82 Growth inhibition assay Inhibition of human J82 cell growth in a cell viability assay. IC50=15.057 μM
JAR Growth inhibition assay Inhibition of human JAR cell growth in a cell viability assay. IC50=19.299 μM
H-EMC-SS Growth inhibition assay Inhibition of human H-EMC-SS cell growth in a cell viability assay. IC50=32.9678 μM
JEG-3 Growth inhibition assay Inhibition of human JEG-3 cell growth in a cell viability assay. IC50=22.378 μM
JVM-2 Growth inhibition assay Inhibition of human JVM-2 cell growth in a cell viability assay. IC50=0.88299 μM
H9 Growth inhibition assay Inhibition of human H9 cell growth in a cell viability assay. IC50=0.07132 μM
KARPAS-299 Growth inhibition assay Inhibition of human KARPAS-299 cell growth in a cell viability assay. IC50=20.3422 μM
JVM-3 Growth inhibition assay Inhibition of human JVM-3 cell growth in a cell viability assay. IC50=7.89599 μM
KALS-1 Growth inhibition assay Inhibition of human KALS-1 cell growth in a cell viability assay. IC50=23.1414 μM
HCC1569 Growth inhibition assay Inhibition of human HCC1569 cell growth in a cell viability assay. IC50=2.58297 μM
KARPAS-45 Growth inhibition assay Inhibition of human KARPAS-45 cell growth in a cell viability assay. IC50=0.01671 μM
KE-37 Growth inhibition assay Inhibition of human KE-37 cell growth in a cell viability assay. IC50=25.7315 μM
KASUMI-1 Growth inhibition assay Inhibition of human KASUMI-1 cell growth in a cell viability assay. IC50=0.00911 μM
KGN Growth inhibition assay Inhibition of human KGN cell growth in a cell viability assay. IC50=32.633 μM
KLE Growth inhibition assay Inhibition of human KLE cell growth in a cell viability assay. IC50=4.40819 μM
HCC1806 Growth inhibition assay Inhibition of human HCC1806 cell growth in a cell viability assay. IC50=0.69666 μM
KM-H2 Growth inhibition assay Inhibition of human KM-H2 cell growth in a cell viability assay. IC50=34.1779 μM
KM12 Growth inhibition assay Inhibition of human KM12 cell growth in a cell viability assay. IC50=22.356 μM
HCC2998 Growth inhibition assay Inhibition of human HCC2998 cell growth in a cell viability assay. IC50=5.52615 μM
KNS-42 Growth inhibition assay Inhibition of human KNS-42 cell growth in a cell viability assay. IC50=35.5826 μM
KMOE-2 Growth inhibition assay Inhibition of human KMOE-2 cell growth in a cell viability assay. IC50=19.2242 μM
HCC70 Growth inhibition assay Inhibition of human HCC70 cell growth in a cell viability assay. IC50=0.57661 μM
HEC-1 Growth inhibition assay Inhibition of human HEC-1 cell growth in a cell viability assay. IC50=3.5895 μM
KP-4 Growth inhibition assay Inhibition of human KP-4 cell growth in a cell viability assay. IC50=42.8832 μM
KNS-81-FD Growth inhibition assay Inhibition of human KNS-81-FD cell growth in a cell viability assay. IC50=19.5468 μM
HGC-27 Growth inhibition assay Inhibition of human HGC-27 cell growth in a cell viability assay. IC50=31.5873 μM
KP-N-YN Growth inhibition assay Inhibition of human KP-N-YN cell growth in a cell viability assay. IC50=37.6195 μM
KP-N-YS Growth inhibition assay Inhibition of human KP-N-YS cell growth in a cell viability assay. IC50=40.6768 μM
KU-19-19 Growth inhibition assay Inhibition of human KU-19-19 cell growth in a cell viability assay. IC50=0.77464 μM
HOP-62 Growth inhibition assay Inhibition of human HOP-62 cell growth in a cell viability assay. IC50=11.6764 μM
HOS Growth inhibition assay Inhibition of human HOS cell growth in a cell viability assay. IC50=39.6273 μM
KURAMOCHI Growth inhibition assay Inhibition of human KURAMOCHI cell growth in a cell viability assay. IC50=7.94811 μM
KY821 Growth inhibition assay Inhibition of human KY821 cell growth in a cell viability assay. IC50=0.0206 μM
KYSE-270 Growth inhibition assay Inhibition of human KYSE-270 cell growth in a cell viability assay. IC50=2.02732 μM
KYSE-140 Growth inhibition assay Inhibition of human KYSE-140 cell growth in a cell viability assay. IC50=0.0833 μM
KYSE-150 Growth inhibition assay Inhibition of human KYSE-150 cell growth in a cell viability assay. IC50=42.1782 μM
KYSE-450 Growth inhibition assay Inhibition of human KYSE-450 cell growth in a cell viability assay. IC50=0.05978 μM
HT Growth inhibition assay Inhibition of human HT cell growth in a cell viability assay. IC50=40.6639 μM
KYSE-180 Growth inhibition assay Inhibition of human KYSE-180 cell growth in a cell viability assay. IC50=0.39089 μM
HT-1197 Growth inhibition assay Inhibition of human HT-1197 cell growth in a cell viability assay. IC50=4.52669 μM
KYSE-520 Growth inhibition assay Inhibition of human KYSE-520 cell growth in a cell viability assay. IC50=5.20839 μM
KYSE-70 Growth inhibition assay Inhibition of human KYSE-70 cell growth in a cell viability assay. IC50=30.5114 μM
HUTU-80 Growth inhibition assay Inhibition of human HUTU-80 cell growth in a cell viability assay. IC50=41.0569 μM
L-363 Growth inhibition assay Inhibition of human L-363 cell growth in a cell viability assay. IC50=16.4577 μM
L-428 Growth inhibition assay Inhibition of human L-428 cell growth in a cell viability assay. IC50=24.5791 μM
LAMA-84 Growth inhibition assay Inhibition of human LAMA-84 cell growth in a cell viability assay. IC50=4.1702 μM
HuCCT1 Growth inhibition assay Inhibition of human HuCCT1 cell growth in a cell viability assay. IC50=10.6034 μM
LB1047-RCC Growth inhibition assay Inhibition of human LB1047-RCC cell growth in a cell viability assay. IC50=2.74888 μM
IGR-1 Growth inhibition assay Inhibition of human IGR-1 cell growth in a cell viability assay. IC50=28.8874 μM
LB2518-MEL Growth inhibition assay Inhibition of human LB2518-MEL cell growth in a cell viability assay. IC50=49.8723 μM
LB373-MEL-D Growth inhibition assay Inhibition of human LB373-MEL-D cell growth in a cell viability assay. IC50=7.76771 μM
LB771-HNC Growth inhibition assay Inhibition of human LB771-HNC cell growth in a cell viability assay. IC50=35.1658 μM
IST-SL1 Growth inhibition assay Inhibition of human IST-SL1 cell growth in a cell viability assay. IC50=26.6591 μM
LCLC-103H Growth inhibition assay Inhibition of human LCLC-103H cell growth in a cell viability assay. IC50=36.7803 μM
LC-2-ad Growth inhibition assay Inhibition of human LC-2-ad cell growth in a cell viability assay. IC50=21.2729 μM
LCLC-97TM1 Growth inhibition assay Inhibition of human LCLC-97TM1 cell growth in a cell viability assay. IC50=4.53686 μM
LN-405 Growth inhibition assay Inhibition of human LN-405 cell growth in a cell viability assay. IC50=22.5913 μM
LK-2 Growth inhibition assay Inhibition of human LK-2 cell growth in a cell viability assay. IC50=13.7639 μM
J-RT3-T3-5 Growth inhibition assay Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay. IC50=6.869 μM
LS-1034 Growth inhibition assay Inhibition of human LS-1034 cell growth in a cell viability assay. IC50=6.20706 μM
LS-123 Growth inhibition assay Inhibition of human LS-123 cell growth in a cell viability assay. IC50=3.74284 μM
K5 Growth inhibition assay Inhibition of human K5 cell growth in a cell viability assay. IC50=1.58357 μM
LS-411N Growth inhibition assay Inhibition of human LS-411N cell growth in a cell viability assay. IC50=5.79441 μM
LU-134-A Growth inhibition assay Inhibition of human LU-134-A cell growth in a cell viability assay. IC50=21.1026 μM
KG-1 Growth inhibition assay Inhibition of human KG-1 cell growth in a cell viability assay. IC50=24.1928 μM
KINGS-1 Growth inhibition assay Inhibition of human KINGS-1 cell growth in a cell viability assay. IC50=5.60944 μM
LU-65 Growth inhibition assay Inhibition of human LU-65 cell growth in a cell viability assay. IC50=0.12633 μM
LU-139 Growth inhibition assay Inhibition of human LU-139 cell growth in a cell viability assay. IC50=0.3051 μM
LU-99A Growth inhibition assay Inhibition of human LU-99A cell growth in a cell viability assay. IC50=37.5731 μM
LXF-289 Growth inhibition assay Inhibition of human LXF-289 cell growth in a cell viability assay. IC50=2.63565 μM
M14 Growth inhibition assay Inhibition of human M14 cell growth in a cell viability assay. IC50=44.1332 μM
KNS-62 Growth inhibition assay Inhibition of human KNS-62 cell growth in a cell viability assay. IC50=3.94731 μM
LoVo Growth inhibition assay Inhibition of human LoVo cell growth in a cell viability assay. IC50=2.10797 μM
KOSC-2 Growth inhibition assay Inhibition of human KOSC-2 cell growth in a cell viability assay. IC50=3.83451 μM
MC-IXC Growth inhibition assay Inhibition of human MC-IXC cell growth in a cell viability assay. IC50=11.6728 μM
MC116 Growth inhibition assay Inhibition of human MC116 cell growth in a cell viability assay. IC50=3.95489 μM
MDA-MB-175-VII Growth inhibition assay Inhibition of human MDA-MB-175-VII cell growth in a cell viability assay. IC50=0.03416 μM
MCF7 Growth inhibition assay Inhibition of human MCF7 cell growth in a cell viability assay. IC50=16.4723 μM
MDA-MB-361 Growth inhibition assay Inhibition of human MDA-MB-361 cell growth in a cell viability assay. IC50=0.72662 μM
KS-1 Growth inhibition assay Inhibition of human KS-1 cell growth in a cell viability assay. IC50=4.50889 μM
MDA-MB-157 Growth inhibition assay Inhibition of human MDA-MB-157 cell growth in a cell viability assay. IC50=2.21828 μM
MDA-MB-453 Growth inhibition assay Inhibition of human MDA-MB-453 cell growth in a cell viability assay. IC50=11.9515 μM
KU812 Growth inhibition assay Inhibition of human KU812 cell growth in a cell viability assay. IC50=0.15456 μM
ME-180 Growth inhibition assay Inhibition of human ME-180 cell growth in a cell viability assay. IC50=1.61096 μM
MEG-01 Growth inhibition assay Inhibition of human MEG-01 cell growth in a cell viability assay. IC50=4.99403 μM
KYSE-410 Growth inhibition assay Inhibition of human KYSE-410 cell growth in a cell viability assay. IC50=1.65672 μM
MEL-HO Growth inhibition assay Inhibition of human MEL-HO cell growth in a cell viability assay. IC50=30.1423 μM
MFE-280 Growth inhibition assay Inhibition of human MFE-280 cell growth in a cell viability assay. IC50=16.0488 μM
MFH-ino Growth inhibition assay Inhibition of human MFH-ino cell growth in a cell viability assay. IC50=37.3371 μM
KYSE-510 Growth inhibition assay Inhibition of human KYSE-510 cell growth in a cell viability assay. IC50=19.8748 μM
MFM-223 Growth inhibition assay Inhibition of human MFM-223 cell growth in a cell viability assay. IC50=16.3965 μM
MG-63 Growth inhibition assay Inhibition of human MG-63 cell growth in a cell viability assay. IC50=5.48762 μM
MHH-NB-11 Growth inhibition assay Inhibition of human MHH-NB-11 cell growth in a cell viability assay. IC50=16.0839 μM
LAN-6 Growth inhibition assay Inhibition of human LAN-6 cell growth in a cell viability assay. IC50=40.0112 μM
MKN1 Growth inhibition assay Inhibition of human MKN1 cell growth in a cell viability assay. IC50=3.47108 μM
MIA-PaCa-2 Growth inhibition assay Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay. IC50=28.7959 μM
MKN28 Growth inhibition assay Inhibition of human MKN28 cell growth in a cell viability assay. IC50=32.7838 μM
ML-2 Growth inhibition assay Inhibition of human ML-2 cell growth in a cell viability assay. IC50=0.24802 μM
MKN45 Growth inhibition assay Inhibition of human MKN45 cell growth in a cell viability assay. IC50=21.1551 μM
MMAC-SF Growth inhibition assay Inhibition of human MMAC-SF cell growth in a cell viability assay. IC50=19.2607 μM
MKN7 Growth inhibition assay Inhibition of human MKN7 cell growth in a cell viability assay. IC50=2.35335 μM
LB2241-RCC Growth inhibition assay Inhibition of human LB2241-RCC cell growth in a cell viability assay. IC50=0.10884 μM
LB831-BLC Growth inhibition assay Inhibition of human LB831-BLC cell growth in a cell viability assay. IC50=38.6039 μM
MOLT-13 Growth inhibition assay Inhibition of human MOLT-13 cell growth in a cell viability assay. IC50=0.23975 μM
MSTO-211H Growth inhibition assay Inhibition of human MSTO-211H cell growth in a cell viability assay. IC50=45.9482 μM
MOLT-16 Growth inhibition assay Inhibition of human MOLT-16 cell growth in a cell viability assay. IC50=17.8935 μM
MOLT-4 Growth inhibition assay Inhibition of human MOLT-4 cell growth in a cell viability assay. IC50=7.02135 μM
MZ1-PC Growth inhibition assay Inhibition of human MZ1-PC cell growth in a cell viability assay. IC50=30.393 μM
MZ2-MEL Growth inhibition assay Inhibition of human MZ2-MEL cell growth in a cell viability assay. IC50=16.8403 μM
MPP-89 Growth inhibition assay Inhibition of human MPP-89 cell growth in a cell viability assay. IC50=22.8661 μM
MZ7-mel Growth inhibition assay Inhibition of human MZ7-mel cell growth in a cell viability assay. IC50=34.6487 μM
LNCaP-Clone-FGC Growth inhibition assay Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay. IC50=15.4248 μM
Mewo Growth inhibition assay Inhibition of human Mewo cell growth in a cell viability assay. IC50=34.1349 μM
LOXIMVI Growth inhibition assay Inhibition of human LOXIMVI cell growth in a cell viability assay. IC50=5.63873 μM
NB12 Growth inhibition assay Inhibition of human NB12 cell growth in a cell viability assay. IC50=25.2947 μM
NB10 Growth inhibition assay Inhibition of human NB10 cell growth in a cell viability assay. IC50=22.2371 μM
NB13 Growth inhibition assay Inhibition of human NB13 cell growth in a cell viability assay. IC50=42.6217 μM
NB5 Growth inhibition assay Inhibition of human NB5 cell growth in a cell viability assay. IC50=1.41317 μM
NB14 Growth inhibition assay Inhibition of human NB14 cell growth in a cell viability assay. IC50=6.43836 μM
LS-513 Growth inhibition assay Inhibition of human LS-513 cell growth in a cell viability assay. IC50=4.31217 μM
NB17 Growth inhibition assay Inhibition of human NB17 cell growth in a cell viability assay. IC50=31.5185 μM
NB69 Growth inhibition assay Inhibition of human NB69 cell growth in a cell viability assay. IC50=1.02945 μM
NCI-H1048 Growth inhibition assay Inhibition of human NCI-H1048 cell growth in a cell viability assay. IC50=2.49158 μM
NBsusSR Growth inhibition assay Inhibition of human NBsusSR cell growth in a cell viability assay. IC50=3.18254 μM
LU-135 Growth inhibition assay Inhibition of human LU-135 cell growth in a cell viability assay. IC50=33.8829 μM
NCI-H1092 Growth inhibition assay Inhibition of human NCI-H1092 cell growth in a cell viability assay. IC50=16.8316 μM
NCI-H1155 Growth inhibition assay Inhibition of human NCI-H1155 cell growth in a cell viability assay. IC50=19.7238 μM
NCI-H1304 Growth inhibition assay Inhibition of human NCI-H1304 cell growth in a cell viability assay. IC50=26.9108 μM
NCI-H1395 Growth inhibition assay Inhibition of human NCI-H1395 cell growth in a cell viability assay. IC50=20.6697 μM
NCI-H1437 Growth inhibition assay Inhibition of human NCI-H1437 cell growth in a cell viability assay. IC50=18.1641 μM
MDA-MB-231 Growth inhibition assay Inhibition of human MDA-MB-231 cell growth in a cell viability assay. IC50=28.2795 μM
MDA-MB-415 Growth inhibition assay Inhibition of human MDA-MB-415 cell growth in a cell viability assay. IC50=23.9498 μM
MHH-ES-1 Growth inhibition assay Inhibition of human MHH-ES-1 cell growth in a cell viability assay. IC50=27.4447 μM
MHH-PREB-1 Growth inhibition assay Inhibition of human MHH-PREB-1 cell growth in a cell viability assay. IC50=10.1999 μM
MLMA Growth inhibition assay Inhibition of human MLMA cell growth in a cell viability assay. IC50=22.747 μM
MN-60 Growth inhibition assay Inhibition of human MN-60 cell growth in a cell viability assay. IC50=7.28089 μM
MS-1 Growth inhibition assay Inhibition of human MS-1 cell growth in a cell viability assay. IC50=30.8889 μM
MV-4-11 Growth inhibition assay Inhibition of human MV-4-11 cell growth in a cell viability assay. IC50=3.87994 μM
Mo-T Growth inhibition assay Inhibition of human Mo-T cell growth in a cell viability assay. IC50=18.8204 μM
NB7 Growth inhibition assay Inhibition of human NB7 cell growth in a cell viability assay. IC50=2.29676 μM
NCI-H1299 Growth inhibition assay Inhibition of human NCI-H1299 cell growth in a cell viability assay. IC50=6.63171 μM
NCI-H1355 Growth inhibition assay Inhibition of human NCI-H1355 cell growth in a cell viability assay. IC50=34.3889 μM
NCI-H1792 Growth inhibition assay Inhibition of human NCI-H1792 cell growth in a cell viability assay. IC50=50.2744 μM
NCI-H2347 Growth inhibition assay Inhibition of human NCI-H2347 cell growth in a cell viability assay. IC50=58.3648 μM
NCI-H2452 Growth inhibition assay Inhibition of human NCI-H2452 cell growth in a cell viability assay. IC50=56.5819 μM
PSN1 Growth inhibition assay Inhibition of human PSN1 cell growth in a cell viability assay. IC50=50.9394 μM
RH-1 Growth inhibition assay Inhibition of human RH-1 cell growth in a cell viability assay. IC50=66.3277 μM
SK-LMS-1 Growth inhibition assay Inhibition of human SK-LMS-1 cell growth in a cell viability assay. IC50=51.9815 μM
SK-MEL-30 Growth inhibition assay Inhibition of human SK-MEL-30 cell growth in a cell viability assay. IC50=133.481 μM
SNB75 Growth inhibition assay Inhibition of human SNB75 cell growth in a cell viability assay. IC50=50.414 μM
SNU-423 Growth inhibition assay Inhibition of human SNU-423 cell growth in a cell viability assay. IC50=70.6017 μM
SW1088 Growth inhibition assay Inhibition of human SW1088 cell growth in a cell viability assay. IC50=50.0201 μM
SW1783 Growth inhibition assay Inhibition of human SW1783 cell growth in a cell viability assay. IC50=52.4982 μM
SBC-5 Growth inhibition assay Inhibition of human SBC-5 cell growth in a cell viability assay. IC50=51.1085 μM
A375 Growth inhibition assay Inhibition of human A375 cell growth in a cell viability assay. IC50=53.6768 μM
AM-38 Growth inhibition assay Inhibition of human AM-38 cell growth in a cell viability assay. IC50=52.9492 μM
YH-13 Growth inhibition assay Inhibition of human YH-13 cell growth in a cell viability assay. IC50=60.0468 μM
TYK-nu Growth inhibition assay Inhibition of human TYK-nu cell growth in a cell viability assay. IC50=76.6063 μM
COLO-668 Growth inhibition assay Inhibition of human COLO-668 cell growth in a cell viability assay. IC50=60.5077 μM
ES6 Growth inhibition assay Inhibition of human ES6 cell growth in a cell viability assay. IC50=57.7541 μM
D-247MG Growth inhibition assay Inhibition of human D-247MG cell growth in a cell viability assay. IC50=59.5888 μM
H4 Growth inhibition assay Inhibition of human H4 cell growth in a cell viability assay. IC50=60.5614 μM
HMV-II Growth inhibition assay Inhibition of human HMV-II cell growth in a cell viability assay. IC50=157.194 μM
HT-1080 Growth inhibition assay Inhibition of human HT-1080 cell growth in a cell viability assay. IC50=62.203 μM
IA-LM Growth inhibition assay Inhibition of human IA-LM cell growth in a cell viability assay. IC50=54.091 μM
K-562 Growth inhibition assay Inhibition of human K-562 cell growth in a cell viability assay. IC50=50.5633 μM
MEL-JUSO Growth inhibition assay Inhibition of human MEL-JUSO cell growth in a cell viability assay. IC50=56.1737 μM
M059J Growth inhibition assay Inhibition of human M059J cell growth in a cell viability assay. IC50=51.0252 μM
NB6 Growth inhibition assay Inhibition of human NB6 cell growth in a cell viability assay. IC50=71.0797 μM
NCI-H1975 Proliferation assay 72 h Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M mutant after 72 hrs by SRB assay, IC50=0.148 μM
A431 Proliferation assay 72 h Antiproliferative activity against human A431 cells after 72 hrs by SRB assay, IC50=0.023 nM
MDA-MB-231 Proliferation assay 72 h Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay, EC50=1 nM
NCI-H1975 Cytotoxicity assay 48 h Cytotoxicity against human NCI-H1975 cells after 48 hrs by MTT assay, IC50=0.392 μM
NIH/3T3 Cytotoxicity assay 48 h Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay, IC50=3.605 μM
A549 Cytotoxicity assay 72 h Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.05 μM
PC3 Cytotoxicity assay 72 h Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50=4.1 μM
HeLa Cytotoxicity assay 72 h Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=6.81 μM
MCF7 Cytotoxicity assay 72 h Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=5.83 μM
NSCLC Cytotoxicity assay 72 h Cytotoxicity against human NSCLC cells, IC50=0.5 nM
Click to View More Cell Line Experimental Data

Biological Activity

Description Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.
Targets
EGFR (L858R) [1]
(Cell-free assay)		 EGFR (wt) [1]
(Cell-free assay)		 EGFR (L858R/T790M) [1]
(Cell-free assay)		 HER2 [1]
(Cell-free assay)
0.4 nM 0.5 nM 10 nM 14 nM
In vitro
In vitro BIBW2992 is more effective than erlotinib, gefitinib, or lapatinib in inhibiting survival of lung cancer cell lines harboring wild-type (H1666) or L858R/T790M (NCI-H1975) EGFR. BIBW2992 is similarly effective against NSCLC lines expressing HER2 776insV (NCI-H1781) or EGFR E746_A750del (HCC827), but shows no activity toward A549 cells, which express wild-type EGFR and HER2.[1] Afatinib enhances cytotoxicity of topotecan and mitoxantrone to SP cells, and increases the apoptosis induced by topotecan and mitoxantrone in SP cells.[2]
Kinase Assay In vitro kinase activity assay
EGFR kinase: Each 100 µL enzyme reaction contained 10 μL of inhibitor in 50% Me2SO, 20 μL of substrate solution (200 mM HEPES pH 7.4, 50 mM Mg-acetate, 2.5 mg/mL poly (EY), 5 μg/mL bio-pEY) and 20 µL enzyme preparation. The enzymatic reaction is started by addition of 50 µL of a 100 µM ATP solution made in 10 mM MgCl2. Assays are carried out at room temperature for 30 min and terminated by the addition of 50 µL of stop solution (250 mM EDTA in 20 mM HEPES pH 7.4). 100 µL are transferred to a streptavidin coated microtiterplate, after an incubation time of 60 min at room temperature the plate is washed with 200 µL of wash solution (50 mM Tris, 0.05% Tween20). A 100 µL aliquot of a HRPO- labeled anti-PY antibody (PY20H Anti-Ptyr:HRP ) 250 ng/mL are added to the wells. After 60 min of incubation, the plate is washed three times with a 200 µL wash solution. The samples are then developed with a 100µL TMB Peroxidase Solution (A:B= 1:1). The reaction is stopped after 10 min. The plate is transferred to an ELISA reader and extinction is measured at OD450nm. HER2-IC enzyme: Enzyme activity is assayed in the presence or absence of serial inhibitor dilutions performed in 50 % Me2SO. Each 100 µL reaction contains similar components as described for EGFR kinase assay with addition of 1000 µM Na3VO4. The enzymatic reaction is started by addition of 50µL of 500 µM ATP solution made in 10 mM Mg-acetate. The dilution of the enzyme is set so that incorporation of phosphate into bio-pEY is linear with respect to time and amount of enzyme. The enzyme preparation is diluted in 20 mM HEPES pH 7.4, 130 mM NaCl, 0.05% Triton X-100, 1 mM DTT and 10% glycerol. Assays are carried out at room temperature for 30 min and terminated by the addition of 50 µL of stop solution. Src kinase assays: Each 100 µL reaction contained 10 µL of inhibitor in 50 % Me2SO, 20µL of enzyme preparation, 20 µL of substrate solution supplemented with 1000 µM Na3VO4. The enzymatic reaction is started by addition of 50 µL of a 1000 µM ATP solution made in 10 mM Mg-acetate. BIRK kinase assay: 250 mM Tris pH 7.4, 10mM DTT, 2.5 mg/mL poly(EY), 5 mg/mL bio-pEY is used as substrate solution and enzymatic reaction is started by addition of 50 µL of a 2 mM ATP solution made in 8 mM MnCl2, 20 mM Mg-acetate. VEGF2 and HGFR kinase assays: Assays are carried out at room temperature for 20 minutes and terminated by the addition of 10 µL of 5 % H3PO4. The precipitate is then trapped onto GF/B filters using a 96 well filter mate universal harvester. After extensive washing the filter plate is dried for 1 h at 50°C, sealed and incorporated radioactivity is determined by scintillation counting using a TopCount™ or a Microbeta b counter™.
Cell Research Cell lines SP and NSP cell lines
Concentrations 1 μM
Incubation Time 48 h
Method Cytotoxicity is determined using MTT assay. The IC 50 value is defined as the drug concentration resulting in 50% cell death. Both the fitted sigmoidal dose response curve and IC50 are calculated by Bliss method.
Experimental Result Images Methods Biomarkers Images PMID
Growth inhibition assay Cell apoptosis Cell viability S7810-viability1 25537503
Western blot CIP2A / p-AKT / AKT / PARP p-EGFR / p-IGF1R / p-ERK / p-AKT S7810-WB1 25537503
Immunofluorescence p65 vacuoles S7810-IF1 26317651
In Vivo
In vivo In the MDA-MB-453 xenograft model, BIBW2992 (20 mg/kg, p.o.) results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%, and downregulation of EGFR and AKT phosphorylation.[1] In A7, A431, FaDu, UT-SCC-14 and UT-SCC-15 xenograft models, application of BIBW 2992 (30 mg/kg, p.o.) leads to a significant prolongation of tumour growth time.[3] In HER2-amplified xenograft medel, Afatinib (30 mg/kg, p.o.) results a markedly inhibition in tumor growth and a significant improvement in the duration of overall survival.[4] In HER2-positive gastric cancer NCI-N87 xenograft, afatinib (25 mg/kg, p.o.) leads to dramatic tumor volume regression within 4 d and near-complete tumor resolution after 21 d of treatment.[5]
Animal Research Animal Models SCID mice harbouring ARK2 xenografts
Dosages 25 mg/kg
Administration p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06302621 Recruiting
Advanced Solid Tumor|Unresectable Solid Tumor|Metastatic Solid Tumor|Cholangiocarcinoma
Massachusetts General Hospital|Boehringer Ingelheim|Incyte Corporation
 July 1 2024 Phase 1
NCT05298176 Recruiting
Non-Small Cell Lung Cancer
Amsterdam UMC location VUmc
 January 4 2022 Phase 2
NCT04795245 Completed
Non-squamous Non-Small Cell Lung Cancer
Boehringer Ingelheim
 August 26 2021 --
NCT04497584 Recruiting
Advanced Squamous Non Small Cell Lung Cancer
University of Texas Southwestern Medical Center
 August 4 2021 Phase 2
NCT04413201 Active not recruiting
Non-squamous NSCLC
Michael Hopp|Boehringer Ingelheim|Johannes Gutenberg University Mainz
 September 11 2020 Phase 4
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748240/
  • https://pubmed.ncbi.nlm.nih.gov/24972892/
  • https://pubmed.ncbi.nlm.nih.gov/25444177/
  • https://pubmed.ncbi.nlm.nih.gov/25268372/
  • https://pubmed.ncbi.nlm.nih.gov/23578997/

Chemical Information & Solubility

Molecular Weight 717.18 Formula

C24H25ClFN5O3.2C4H4O4
CAS No. 850140-73-7 SDF Download Afatinib Dimaleate SDF
Smiles CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (139.43 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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