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research use only
Afatinib Dimaleate EGFR inhibitor
Cat.No.S7810
Chemical Structure
Molecular Weight: 717.18
Jump to
Quality Control
Batch:
Purity:
99.98%
99.98
| Related Targets | VEGFR PDGFR FGFR c-Met Src MEK CSF-1R FLT3 HER2 c-Kit |
|---|---|
| Other EGFR Inhibitors | Lazertinib (YH25448) Icotinib Hydrochloride Sunvozertinib AG-490 AG-1478 Canertinib (CI-1033) WZ4002 Poziotinib (NOV120101, HM781-36B) Rociletinib (CO-1686) Genistein |
Cell Culture, Treatment & Working Concentration
| Cell Lines | Assay Type | Concentration | Incubation Time | Formulation | Activity Description | PMID |
|---|---|---|---|---|---|---|
| HCC827 cell | Proliferation assay | Antiproliferative activity against human HCC827 cells after 96 hrs by MTS assay, IC50=8 nM | ||||
| NCI-H1563 | Growth inhibition assay | Inhibition of human NCI-H1563 cell growth in a cell viability assay. IC50=9.76031 μM | ||||
| NCI-H1573 | Growth inhibition assay | Inhibition of human NCI-H1573 cell growth in a cell viability assay. IC50=0.7363 μM | ||||
| NCI-H1581 | Growth inhibition assay | Inhibition of human NCI-H1581 cell growth in a cell viability assay. IC50=29.3145 μM | ||||
| NCI-H1648 | Growth inhibition assay | Inhibition of human NCI-H1648 cell growth in a cell viability assay. IC50=0.44182 μM | ||||
| NCI-H1793 | Growth inhibition assay | Inhibition of human NCI-H1793 cell growth in a cell viability assay. IC50=14.2087 μM | ||||
| NCI-H1838 | Growth inhibition assay | Inhibition of human NCI-H1838 cell growth in a cell viability assay. IC50=0.60299 μM | ||||
| NCI-H1770 | Growth inhibition assay | Inhibition of human NCI-H1770 cell growth in a cell viability assay. IC50=0.1028 μM | ||||
| NCI-H1651 | Growth inhibition assay | Inhibition of human NCI-H1651 cell growth in a cell viability assay. IC50=25.597 μM | ||||
| NCI-H1975 | Growth inhibition assay | Inhibition of human NCI-H1975 cell growth in a cell viability assay. IC50=0.61728 μM | ||||
| NCI-H1666 | Growth inhibition assay | Inhibition of human NCI-H1666 cell growth in a cell viability assay. IC50=1.80948 μM | ||||
| NCI-H2009 | Growth inhibition assay | Inhibition of human NCI-H2009 cell growth in a cell viability assay. IC50=3.61216 μM | ||||
| NCI-H2126 | Growth inhibition assay | Inhibition of human NCI-H2126 cell growth in a cell viability assay. IC50=0.51926 μM | ||||
| NCI-H1693 | Growth inhibition assay | Inhibition of human NCI-H1693 cell growth in a cell viability assay. IC50=3.84181 μM | ||||
| NCI-H2087 | Growth inhibition assay | Inhibition of human NCI-H2087 cell growth in a cell viability assay. IC50=49.9682 μM | ||||
| NCI-H2029 | Growth inhibition assay | Inhibition of human NCI-H2029 cell growth in a cell viability assay. IC50=43.5581 μM | ||||
| NCI-H2170 | Growth inhibition assay | Inhibition of human NCI-H2170 cell growth in a cell viability assay. IC50=0.03728 μM | ||||
| NCI-H226 | Growth inhibition assay | Inhibition of human NCI-H226 cell growth in a cell viability assay. IC50=49.7785 μM | ||||
| NCI-H2030 | Growth inhibition assay | Inhibition of human NCI-H2030 cell growth in a cell viability assay. IC50=14.6448 μM | ||||
| NCI-H2052 | Growth inhibition assay | Inhibition of human NCI-H2052 cell growth in a cell viability assay. IC50=21.8963 μM | ||||
| NCI-H292 | Growth inhibition assay | Inhibition of human NCI-H292 cell growth in a cell viability assay. IC50=0.0609 μM | ||||
| NCI-H441 | Growth inhibition assay | Inhibition of human NCI-H441 cell growth in a cell viability assay. IC50=3.59841 μM | ||||
| NCI-H2291 | Growth inhibition assay | Inhibition of human NCI-H2291 cell growth in a cell viability assay. IC50=5.98943 μM | ||||
| NCI-H358 | Growth inhibition assay | Inhibition of human NCI-H358 cell growth in a cell viability assay. IC50=0.5321 μM | ||||
| NCI-H460 | Growth inhibition assay | Inhibition of human NCI-H460 cell growth in a cell viability assay. IC50=46.523 μM | ||||
| NCI-H661 | Growth inhibition assay | Inhibition of human NCI-H661 cell growth in a cell viability assay. IC50=16.9694 μM | ||||
| NCI-H23 | Growth inhibition assay | Inhibition of human NCI-H23 cell growth in a cell viability assay. IC50=37.4196 μM | ||||
| NCI-H630 | Growth inhibition assay | Inhibition of human NCI-H630 cell growth in a cell viability assay. IC50=1.45582 μM | ||||
| NCI-H2342 | Growth inhibition assay | Inhibition of human NCI-H2342 cell growth in a cell viability assay. IC50=17.557 μM | ||||
| NCI-H69 | Growth inhibition assay | Inhibition of human NCI-H69 cell growth in a cell viability assay. IC50=0.21451 μM | ||||
| NCI-H650 | Growth inhibition assay | Inhibition of human NCI-H650 cell growth in a cell viability assay. IC50=11.2418 μM | ||||
| NCI-H747 | Growth inhibition assay | Inhibition of human NCI-H747 cell growth in a cell viability assay. IC50=5.42472 μM | ||||
| NCI-H2405 | Growth inhibition assay | Inhibition of human NCI-H2405 cell growth in a cell viability assay. IC50=17.1974 μM | ||||
| NCI-H520 | Growth inhibition assay | Inhibition of human NCI-H520 cell growth in a cell viability assay. IC50=24.8861 μM | ||||
| NCI-H810 | Growth inhibition assay | Inhibition of human NCI-H810 cell growth in a cell viability assay. IC50=34.7278 μM | ||||
| NCI-H720 | Growth inhibition assay | Inhibition of human NCI-H720 cell growth in a cell viability assay. IC50=0.05325 μM | ||||
| NCI-SNU-1 | Growth inhibition assay | Inhibition of human NCI-SNU-1 cell growth in a cell viability assay. IC50=3.69735 μM | ||||
| NH-12 | Growth inhibition assay | Inhibition of human NH-12 cell growth in a cell viability assay. IC50=7.72808 μM | ||||
| NCI-SNU-5 | Growth inhibition assay | Inhibition of human NCI-SNU-5 cell growth in a cell viability assay. IC50=1.239 μM | ||||
| NKM-1 | Growth inhibition assay | Inhibition of human NKM-1 cell growth in a cell viability assay. IC50=3.18744 μM | ||||
| NCI-H526 | Growth inhibition assay | Inhibition of human NCI-H526 cell growth in a cell viability assay. IC50=0.07823 μM | ||||
| NTERA-S-cl-D1 | Growth inhibition assay | Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay. IC50=5.54537 μM | ||||
| NMC-G1 | Growth inhibition assay | Inhibition of human NMC-G1 cell growth in a cell viability assay. IC50=12.9234 μM | ||||
| NCI-H82 | Growth inhibition assay | Inhibition of human NCI-H82 cell growth in a cell viability assay. IC50=1.54006 μM | ||||
| NCI-H1623 | Growth inhibition assay | Inhibition of human NCI-H1623 cell growth in a cell viability assay. IC50=0.08025 μM | ||||
| NOMO-1 | Growth inhibition assay | Inhibition of human NOMO-1 cell growth in a cell viability assay. IC50=34.5703 μM | ||||
| NCI-N87 | Growth inhibition assay | Inhibition of human NCI-N87 cell growth in a cell viability assay. IC50=0.02773 μM | ||||
| NCI-H1650 | Growth inhibition assay | Inhibition of human NCI-H1650 cell growth in a cell viability assay. IC50=9.60946 μM | ||||
| NCI-H1703 | Growth inhibition assay | Inhibition of human NCI-H1703 cell growth in a cell viability assay. IC50=9.34375 μM | ||||
| NCI-H1755 | Growth inhibition assay | Inhibition of human NCI-H1755 cell growth in a cell viability assay. IC50=41.8725 μM | ||||
| NCI-H1993 | Growth inhibition assay | Inhibition of human NCI-H1993 cell growth in a cell viability assay. IC50=8.33631 μM | ||||
| NCI-H209 | Growth inhibition assay | Inhibition of human NCI-H209 cell growth in a cell viability assay. IC50=0.2046 μM | ||||
| NCI-H2122 | Growth inhibition assay | Inhibition of human NCI-H2122 cell growth in a cell viability assay. IC50=34.3471 μM | ||||
| NY | Growth inhibition assay | Inhibition of human NY cell growth in a cell viability assay. IC50=3.53655 μM | ||||
| OAW-42 | Growth inhibition assay | Inhibition of human OAW-42 cell growth in a cell viability assay. IC50=3.50026 μM | ||||
| OC-314 | Growth inhibition assay | Inhibition of human OC-314 cell growth in a cell viability assay. IC50=15.4714 μM | ||||
| NCI-H2228 | Growth inhibition assay | Inhibition of human NCI-H2228 cell growth in a cell viability assay. IC50=32.6602 μM | ||||
| OCI-AML2 | Growth inhibition assay | Inhibition of human OCI-AML2 cell growth in a cell viability assay. IC50=8.95481 μM | ||||
| OCUB-M | Growth inhibition assay | Inhibition of human OCUB-M cell growth in a cell viability assay. IC50=3.76187 μM | ||||
| OE33 | Growth inhibition assay | Inhibition of human OE33 cell growth in a cell viability assay. IC50=13.786 μM | ||||
| NCI-H28 | Growth inhibition assay | Inhibition of human NCI-H28 cell growth in a cell viability assay. IC50=7.16405 μM | ||||
| OS-RC-2 | Growth inhibition assay | Inhibition of human OS-RC-2 cell growth in a cell viability assay. IC50=9.0219 μM | ||||
| ONS-76 | Growth inhibition assay | Inhibition of human ONS-76 cell growth in a cell viability assay. IC50=41.4709 μM | ||||
| OVCAR-3 | Growth inhibition assay | Inhibition of human OVCAR-3 cell growth in a cell viability assay. IC50=2.67167 μM | ||||
| OVCAR-4 | Growth inhibition assay | Inhibition of human OVCAR-4 cell growth in a cell viability assay. IC50=10.8835 μM | ||||
| OVCAR-5 | Growth inhibition assay | Inhibition of human OVCAR-5 cell growth in a cell viability assay. IC50=13.1593 μM | ||||
| P12-ICHIKAWA | Growth inhibition assay | Inhibition of human P12-ICHIKAWA cell growth in a cell viability assay. IC50=25.4785 μM | ||||
| NCI-H446 | Growth inhibition assay | Inhibition of human NCI-H446 cell growth in a cell viability assay. IC50=37.4862 μM | ||||
| NCI-H510A | Growth inhibition assay | Inhibition of human NCI-H510A cell growth in a cell viability assay. IC50=31.4006 μM | ||||
| NCI-H596 | Growth inhibition assay | Inhibition of human NCI-H596 cell growth in a cell viability assay. IC50=12.0369 μM | ||||
| PA-1 | Growth inhibition assay | Inhibition of human PA-1 cell growth in a cell viability assay. IC50=49.8335 μM | ||||
| PC-14 | Growth inhibition assay | Inhibition of human PC-14 cell growth in a cell viability assay. IC50=0.05668 μM | ||||
| PANC-03-27 | Growth inhibition assay | Inhibition of human PANC-03-27 cell growth in a cell viability assay. IC50=2.16631 μM | ||||
| PANC-08-13 | Growth inhibition assay | Inhibition of human PANC-08-13 cell growth in a cell viability assay. IC50=1.16416 μM | ||||
| NCI-H727 | Growth inhibition assay | Inhibition of human NCI-H727 cell growth in a cell viability assay. IC50=8.1042 μM | ||||
| RD | Growth inhibition assay | Inhibition of human RD cell growth in a cell viability assay. IC50=29.5233 μM | ||||
| QIMR-WIL | Growth inhibition assay | Inhibition of human QIMR-WIL cell growth in a cell viability assay. IC50=16.7105 μM | ||||
| RERF-LC-MS | Growth inhibition assay | Inhibition of human RERF-LC-MS cell growth in a cell viability assay. IC50=17.5508 μM | ||||
| RCC10RGB | Growth inhibition assay | Inhibition of human RCC10RGB cell growth in a cell viability assay. IC50=18.0559 μM | ||||
| RH-18 | Growth inhibition assay | Inhibition of human RH-18 cell growth in a cell viability assay. IC50=18.0035 μM | ||||
| RO82-W-1 | Growth inhibition assay | Inhibition of human RO82-W-1 cell growth in a cell viability assay. IC50=32.1604 μM | ||||
| RKO | Growth inhibition assay | Inhibition of human RKO cell growth in a cell viability assay. IC50=14.5075 μM | ||||
| RPMI-7951 | Growth inhibition assay | Inhibition of human RPMI-7951 cell growth in a cell viability assay. IC50=3.0759 μM | ||||
| NEC8 | Growth inhibition assay | Inhibition of human NEC8 cell growth in a cell viability assay. IC50=14.5472 μM | ||||
| RPMI-8226 | Growth inhibition assay | Inhibition of human RPMI-8226 cell growth in a cell viability assay. IC50=4.11631 μM | ||||
| RS4-11 | Growth inhibition assay | Inhibition of human RS4-11 cell growth in a cell viability assay. IC50=12.1725 μM | ||||
| RXF393 | Growth inhibition assay | Inhibition of human RXF393 cell growth in a cell viability assay. IC50=36.3785 μM | ||||
| NOS-1 | Growth inhibition assay | Inhibition of human NOS-1 cell growth in a cell viability assay. IC50=11.711 μM | ||||
| Ramos-2G6-4C10 | Growth inhibition assay | Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay. IC50=14.0202 μM | ||||
| S-117 | Growth inhibition assay | Inhibition of human S-117 cell growth in a cell viability assay. IC50=36.3008 μM | ||||
| SCC-25 | Growth inhibition assay | Inhibition of human SCC-25 cell growth in a cell viability assay. IC50=0.84171 μM | ||||
| SBC-1 | Growth inhibition assay | Inhibition of human SBC-1 cell growth in a cell viability assay. IC50=0.18959 μM | ||||
| SCC-15 | Growth inhibition assay | Inhibition of human SCC-15 cell growth in a cell viability assay. IC50=1.39451 μM | ||||
| SCC-4 | Growth inhibition assay | Inhibition of human SCC-4 cell growth in a cell viability assay. IC50=8.44059 μM | ||||
| NUGC-3 | Growth inhibition assay | Inhibition of human NUGC-3 cell growth in a cell viability assay. IC50=0.38373 μM | ||||
| SCC-9 | Growth inhibition assay | Inhibition of human SCC-9 cell growth in a cell viability assay. IC50=37.7838 μM | ||||
| SCH | Growth inhibition assay | Inhibition of human SCH cell growth in a cell viability assay. IC50=18.6456 μM | ||||
| OAW-28 | Growth inhibition assay | Inhibition of human OAW-28 cell growth in a cell viability assay. IC50=7.94578 μM | ||||
| SF126 | Growth inhibition assay | Inhibition of human SF126 cell growth in a cell viability assay. IC50=23.6924 μM | ||||
| SF295 | Growth inhibition assay | Inhibition of human SF295 cell growth in a cell viability assay. IC50=26.0425 μM | ||||
| OE19 | Growth inhibition assay | Inhibition of human OE19 cell growth in a cell viability assay. IC50=1.71512 μM | ||||
| SF539 | Growth inhibition assay | Inhibition of human SF539 cell growth in a cell viability assay. IC50=9.23562 μM | ||||
| SH-4 | Growth inhibition assay | Inhibition of human SH-4 cell growth in a cell viability assay. IC50=32.1858 μM | ||||
| SHP-77 | Growth inhibition assay | Inhibition of human SHP-77 cell growth in a cell viability assay. IC50=29.6182 μM | ||||
| OMC-1 | Growth inhibition assay | Inhibition of human OMC-1 cell growth in a cell viability assay. IC50=2.08169 μM | ||||
| SK-HEP-1 | Growth inhibition assay | Inhibition of human SK-HEP-1 cell growth in a cell viability assay. IC50=30.6326 μM | ||||
| SJSA-1 | Growth inhibition assay | Inhibition of human SJSA-1 cell growth in a cell viability assay. IC50=27.0176 μM | ||||
| OVCAR-8 | Growth inhibition assay | Inhibition of human OVCAR-8 cell growth in a cell viability assay. IC50=15.8861 μM | ||||
| SK-LU-1 | Growth inhibition assay | Inhibition of human SK-LU-1 cell growth in a cell viability assay. IC50=40.6568 μM | ||||
| SK-MEL-1 | Growth inhibition assay | Inhibition of human SK-MEL-1 cell growth in a cell viability assay. IC50=13.7135 μM | ||||
| SK-MEL-24 | Growth inhibition assay | Inhibition of human SK-MEL-24 cell growth in a cell viability assay. IC50=11.2366 μM | ||||
| P30-OHK | Growth inhibition assay | Inhibition of human P30-OHK cell growth in a cell viability assay. IC50=35.8752 μM | ||||
| PANC-10-05 | Growth inhibition assay | Inhibition of human PANC-10-05 cell growth in a cell viability assay. IC50=14.6247 μM | ||||
| SK-MEL-3 | Growth inhibition assay | Inhibition of human SK-MEL-3 cell growth in a cell viability assay. IC50=16.4787 μM | ||||
| SK-MES-1 | Growth inhibition assay | Inhibition of human SK-MES-1 cell growth in a cell viability assay. IC50=1.11487 μM | ||||
| PC-3 | Growth inhibition assay | Inhibition of human PC-3 cell growth in a cell viability assay. IC50=19.9604 μM | ||||
| SK-NEP-1 | Growth inhibition assay | Inhibition of human SK-NEP-1 cell growth in a cell viability assay. IC50=1.17513 μM | ||||
| SK-N-DZ | Growth inhibition assay | Inhibition of human SK-N-DZ cell growth in a cell viability assay. IC50=28.6885 μM | ||||
| SK-OV-3 | Growth inhibition assay | Inhibition of human SK-OV-3 cell growth in a cell viability assay. IC50=8.71329 μM | ||||
| PFSK-1 | Growth inhibition assay | Inhibition of human PFSK-1 cell growth in a cell viability assay. IC50=13.06 μM | ||||
| SK-PN-DW | Growth inhibition assay | Inhibition of human SK-PN-DW cell growth in a cell viability assay. IC50=35.4369 μM | ||||
| SK-UT-1 | Growth inhibition assay | Inhibition of human SK-UT-1 cell growth in a cell viability assay. IC50=13.1083 μM | ||||
| RCM-1 | Growth inhibition assay | Inhibition of human RCM-1 cell growth in a cell viability assay. IC50=2.52938 μM | ||||
| SKG-IIIa | Growth inhibition assay | Inhibition of human SKG-IIIa cell growth in a cell viability assay. IC50=3.52237 μM | ||||
| SNU-387 | Growth inhibition assay | Inhibition of human SNU-387 cell growth in a cell viability assay. IC50=40.4553 μM | ||||
| SNU-449 | Growth inhibition assay | Inhibition of human SNU-449 cell growth in a cell viability assay. IC50=3.65826 μM | ||||
| RMG-I | Growth inhibition assay | Inhibition of human RMG-I cell growth in a cell viability assay. IC50=7.39296 μM | ||||
| SNU-C2B | Growth inhibition assay | Inhibition of human SNU-C2B cell growth in a cell viability assay. IC50=2.68616 μM | ||||
| RPMI-2650 | Growth inhibition assay | Inhibition of human RPMI-2650 cell growth in a cell viability assay. IC50=11.5885 μM | ||||
| SW1116 | Growth inhibition assay | Inhibition of human SW1116 cell growth in a cell viability assay. IC50=1.01287 μM | ||||
| SW13 | Growth inhibition assay | Inhibition of human SW13 cell growth in a cell viability assay. IC50=0.16216 μM | ||||
| SW1463 | Growth inhibition assay | Inhibition of human SW1463 cell growth in a cell viability assay. IC50=15.0485 μM | ||||
| RPMI-8866 | Growth inhibition assay | Inhibition of human RPMI-8866 cell growth in a cell viability assay. IC50=27.7562 μM | ||||
| RT-112 | Growth inhibition assay | Inhibition of human RT-112 cell growth in a cell viability assay. IC50=22.8616 μM | ||||
| SW1710 | Growth inhibition assay | Inhibition of human SW1710 cell growth in a cell viability assay. IC50=8.18515 μM | ||||
| RVH-421 | Growth inhibition assay | Inhibition of human RVH-421 cell growth in a cell viability assay. IC50=35.7645 μM | ||||
| SW626 | Growth inhibition assay | Inhibition of human SW626 cell growth in a cell viability assay. IC50=11.5755 μM | ||||
| SW1990 | Growth inhibition assay | Inhibition of human SW1990 cell growth in a cell viability assay. IC50=16.1755 μM | ||||
| SW756 | Growth inhibition assay | Inhibition of human SW756 cell growth in a cell viability assay. IC50=6.91176 μM | ||||
| SW48 | Growth inhibition assay | Inhibition of human SW48 cell growth in a cell viability assay. IC50=1.25432 μM | ||||
| SW620 | Growth inhibition assay | Inhibition of human SW620 cell growth in a cell viability assay. IC50=5.24964 μM | ||||
| SAS | Growth inhibition assay | Inhibition of human SAS cell growth in a cell viability assay. IC50=0.48398 μM | ||||
| SW837 | Growth inhibition assay | Inhibition of human SW837 cell growth in a cell viability assay. IC50=12.9028 μM | ||||
| SW872 | Growth inhibition assay | Inhibition of human SW872 cell growth in a cell viability assay. IC50=42.6331 μM | ||||
| SW900 | Growth inhibition assay | Inhibition of human SW900 cell growth in a cell viability assay. IC50=7.82121 μM | ||||
| SW948 | Growth inhibition assay | Inhibition of human SW948 cell growth in a cell viability assay. IC50=46.4462 μM | ||||
| SiHa | Growth inhibition assay | Inhibition of human SiHa cell growth in a cell viability assay. IC50=23.9327 μM | ||||
| SW962 | Growth inhibition assay | Inhibition of human SW962 cell growth in a cell viability assay. IC50=5.62032 μM | ||||
| T-24 | Growth inhibition assay | Inhibition of human T-24 cell growth in a cell viability assay. IC50=34.0205 μM | ||||
| Saos-2 | Growth inhibition assay | Inhibition of human Saos-2 cell growth in a cell viability assay. IC50=19.1162 μM | ||||
| T47D | Growth inhibition assay | Inhibition of human T47D cell growth in a cell viability assay. IC50=3.62217 μM | ||||
| T98G | Growth inhibition assay | Inhibition of human T98G cell growth in a cell viability assay. IC50=27.5846 μM | ||||
| T84 | Growth inhibition assay | Inhibition of human T84 cell growth in a cell viability assay. IC50=11.3907 μM | ||||
| SF268 | Growth inhibition assay | Inhibition of human SF268 cell growth in a cell viability assay. IC50=29.5932 μM | ||||
| 22RV1 | Growth inhibition assay | Inhibition of human 22RV1 cell growth in a cell viability assay. IC50=34.1754 μM | ||||
| TE-1 | Growth inhibition assay | Inhibition of human TE-1 cell growth in a cell viability assay. IC50=1.81475 μM | ||||
| 23132-87 | Growth inhibition assay | Inhibition of human 23132-87 cell growth in a cell viability assay. IC50=0.31923 μM | ||||
| SJRH30 | Growth inhibition assay | Inhibition of human SJRH30 cell growth in a cell viability assay. IC50=30.2108 μM | ||||
| 5637 | Growth inhibition assay | Inhibition of human 5637 cell growth in a cell viability assay. IC50=1.0151 μM | ||||
| 647-V | Growth inhibition assay | Inhibition of human 647-V cell growth in a cell viability assay. IC50=3.98452 μM | ||||
| 639-V | Growth inhibition assay | Inhibition of human 639-V cell growth in a cell viability assay. IC50=31.5243 μM | ||||
| 769-P | Growth inhibition assay | Inhibition of human 769-P cell growth in a cell viability assay. IC50=2.29037 μM | ||||
| 8-MG-BA | Growth inhibition assay | Inhibition of human 8-MG-BA cell growth in a cell viability assay. IC50=36.9483 μM | ||||
| 8305C | Growth inhibition assay | Inhibition of human 8305C cell growth in a cell viability assay. IC50=3.75911 μM | ||||
| SK-MEL-2 | Growth inhibition assay | Inhibition of human SK-MEL-2 cell growth in a cell viability assay. IC50=32.6527 μM | ||||
| 8505C | Growth inhibition assay | Inhibition of human 8505C cell growth in a cell viability assay. IC50=13.2067 μM | ||||
| A204 | Growth inhibition assay | Inhibition of human A204 cell growth in a cell viability assay. IC50=32.5069 μM | ||||
| A101D | Growth inhibition assay | Inhibition of human A101D cell growth in a cell viability assay. IC50=49.9425 μM | ||||
| SK-MEL-28 | Growth inhibition assay | Inhibition of human SK-MEL-28 cell growth in a cell viability assay. IC50=19.3363 μM | ||||
| SK-N-AS | Growth inhibition assay | Inhibition of human SK-N-AS cell growth in a cell viability assay. IC50=21.8275 μM | ||||
| A2780 | Growth inhibition assay | Inhibition of human A2780 cell growth in a cell viability assay. IC50=2.06294 μM | ||||
| A3-KAW | Growth inhibition assay | Inhibition of human A3-KAW cell growth in a cell viability assay. IC50=23.1003 μM | ||||
| A4-Fuk | Growth inhibition assay | Inhibition of human A4-Fuk cell growth in a cell viability assay. IC50=22.1419 μM | ||||
| A431 | Growth inhibition assay | Inhibition of human A431 cell growth in a cell viability assay. IC50=0.48233 μM | ||||
| A388 | Growth inhibition assay | Inhibition of human A388 cell growth in a cell viability assay. IC50=0.36857 μM | ||||
| SK-N-FI | Growth inhibition assay | Inhibition of human SK-N-FI cell growth in a cell viability assay. IC50=28.433 μM | ||||
| A549 | Growth inhibition assay | Inhibition of human A549 cell growth in a cell viability assay. IC50=6.12553 μM | ||||
| A673 | Growth inhibition assay | Inhibition of human A673 cell growth in a cell viability assay. IC50=41.5157 μM | ||||
| ACN | Growth inhibition assay | Inhibition of human ACN cell growth in a cell viability assay. IC50=0.55094 μM | ||||
| A704 | Growth inhibition assay | Inhibition of human A704 cell growth in a cell viability assay. IC50=18.4753 μM | ||||
| SN12C | Growth inhibition assay | Inhibition of human SN12C cell growth in a cell viability assay. IC50=2.91964 μM | ||||
| ALL-PO | Growth inhibition assay | Inhibition of human ALL-PO cell growth in a cell viability assay. IC50=11.2512 μM | ||||
| ABC-1 | Growth inhibition assay | Inhibition of human ABC-1 cell growth in a cell viability assay. IC50=34.3693 μM | ||||
| ACHN | Growth inhibition assay | Inhibition of human ACHN cell growth in a cell viability assay. IC50=0.31994 μM | ||||
| AN3-CA | Growth inhibition assay | Inhibition of human AN3-CA cell growth in a cell viability assay. IC50=28.4395 μM | ||||
| ATN-1 | Growth inhibition assay | Inhibition of human ATN-1 cell growth in a cell viability assay. IC50=33.1416 μM | ||||
| AU565 | Growth inhibition assay | Inhibition of human AU565 cell growth in a cell viability assay. IC50=0.08504 μM | ||||
| BALL-1 | Growth inhibition assay | Inhibition of human BALL-1 cell growth in a cell viability assay. IC50=9.21907 μM | ||||
| BB65-RCC | Growth inhibition assay | Inhibition of human BB65-RCC cell growth in a cell viability assay. IC50=0.34593 μM | ||||
| BB49-HNC | Growth inhibition assay | Inhibition of human BB49-HNC cell growth in a cell viability assay. IC50=43.2356 μM | ||||
| SW1417 | Growth inhibition assay | Inhibition of human SW1417 cell growth in a cell viability assay. IC50=4.12147 μM | ||||
| BHY | Growth inhibition assay | Inhibition of human BHY cell growth in a cell viability assay. IC50=0.28655 μM | ||||
| BCPAP | Growth inhibition assay | Inhibition of human BCPAP cell growth in a cell viability assay. IC50=27.137 μM | ||||
| BFTC-905 | Growth inhibition assay | Inhibition of human BFTC-905 cell growth in a cell viability assay. IC50=29.2706 μM | ||||
| BE-13 | Growth inhibition assay | Inhibition of human BE-13 cell growth in a cell viability assay. IC50=7.98112 μM | ||||
| BHT-101 | Growth inhibition assay | Inhibition of human BHT-101 cell growth in a cell viability assay. IC50=14.241 μM | ||||
| SW1573 | Growth inhibition assay | Inhibition of human SW1573 cell growth in a cell viability assay. IC50=11.7294 μM | ||||
| SW684 | Growth inhibition assay | Inhibition of human SW684 cell growth in a cell viability assay. IC50=19.1326 μM | ||||
| BPH-1 | Growth inhibition assay | Inhibition of human BPH-1 cell growth in a cell viability assay. IC50=0.05988 μM | ||||
| SW780 | Growth inhibition assay | Inhibition of human SW780 cell growth in a cell viability assay. IC50=25.3264 μM | ||||
| BT-474 | Growth inhibition assay | Inhibition of human BT-474 cell growth in a cell viability assay. IC50=0.04986 μM | ||||
| SW954 | Growth inhibition assay | Inhibition of human SW954 cell growth in a cell viability assay. IC50=1.20214 μM | ||||
| C2BBe1 | Growth inhibition assay | Inhibition of human C2BBe1 cell growth in a cell viability assay. IC50=14.764 μM | ||||
| BV-173 | Growth inhibition assay | Inhibition of human BV-173 cell growth in a cell viability assay. IC50=0.17596 μM | ||||
| SW982 | Growth inhibition assay | Inhibition of human SW982 cell growth in a cell viability assay. IC50=18.2671 μM | ||||
| Becker | Growth inhibition assay | Inhibition of human Becker cell growth in a cell viability assay. IC50=20.7201 μM | ||||
| BxPC-3 | Growth inhibition assay | Inhibition of human BxPC-3 cell growth in a cell viability assay. IC50=10.0973 μM | ||||
| C8166 | Growth inhibition assay | Inhibition of human C8166 cell growth in a cell viability assay. IC50=33.8854 μM | ||||
| C-33-A | Growth inhibition assay | Inhibition of human C-33-A cell growth in a cell viability assay. IC50=0.81297 μM | ||||
| C3A | Growth inhibition assay | Inhibition of human C3A cell growth in a cell viability assay. IC50=30.2927 μM | ||||
| CAKI-1 | Growth inhibition assay | Inhibition of human CAKI-1 cell growth in a cell viability assay. IC50=1.78211 μM | ||||
| TCCSUP | Growth inhibition assay | Inhibition of human TCCSUP cell growth in a cell viability assay. IC50=28.6418 μM | ||||
| CAL-120 | Growth inhibition assay | Inhibition of human CAL-120 cell growth in a cell viability assay. IC50=15.1447 μM | ||||
| CAL-12T | Growth inhibition assay | Inhibition of human CAL-12T cell growth in a cell viability assay. IC50=1.88945 μM | ||||
| CAL-27 | Growth inhibition assay | Inhibition of human CAL-27 cell growth in a cell viability assay. IC50=0.17636 μM | ||||
| CAL-51 | Growth inhibition assay | Inhibition of human CAL-51 cell growth in a cell viability assay. IC50=31.5667 μM | ||||
| CAL-39 | Growth inhibition assay | Inhibition of human CAL-39 cell growth in a cell viability assay. IC50=0.11792 μM | ||||
| CAL-54 | Growth inhibition assay | Inhibition of human CAL-54 cell growth in a cell viability assay. IC50=0.61621 μM | ||||
| 697 | Growth inhibition assay | Inhibition of human 697 cell growth in a cell viability assay. IC50=28.6331 μM | ||||
| CAL-85-1 | Growth inhibition assay | Inhibition of human CAL-85-1 cell growth in a cell viability assay. IC50=9.87383 μM | ||||
| CAL-62 | Growth inhibition assay | Inhibition of human CAL-62 cell growth in a cell viability assay. IC50=43.4028 μM | ||||
| CAL-72 | Growth inhibition assay | Inhibition of human CAL-72 cell growth in a cell viability assay. IC50=10.9391 μM | ||||
| 786-0 | Growth inhibition assay | Inhibition of human 786-0 cell growth in a cell viability assay. IC50=3.06408 μM | ||||
| TE-11 | Growth inhibition assay | Inhibition of human TE-11 cell growth in a cell viability assay. IC50=26.7752 μM | ||||
| A172 | Growth inhibition assay | Inhibition of human A172 cell growth in a cell viability assay. IC50=12.0798 μM | ||||
| TE-5 | Growth inhibition assay | Inhibition of human TE-5 cell growth in a cell viability assay. IC50=5.4085 μM | ||||
| TE-6 | Growth inhibition assay | Inhibition of human TE-6 cell growth in a cell viability assay. IC50=0.40246 μM | ||||
| TE-9 | Growth inhibition assay | Inhibition of human TE-9 cell growth in a cell viability assay. IC50=3.84382 μM | ||||
| TGBC24TKB | Growth inhibition assay | Inhibition of human TGBC24TKB cell growth in a cell viability assay. IC50=1.6823 μM | ||||
| A2058 | Growth inhibition assay | Inhibition of human A2058 cell growth in a cell viability assay. IC50=15.0409 μM | ||||
| TI-73 | Growth inhibition assay | Inhibition of human TI-73 cell growth in a cell viability assay. IC50=0.14715 μM | ||||
| A427 | Growth inhibition assay | Inhibition of human A427 cell growth in a cell viability assay. IC50=37.9107 μM | ||||
| TK10 | Growth inhibition assay | Inhibition of human TK10 cell growth in a cell viability assay. IC50=0.26738 μM | ||||
| TGBC1TKB | Growth inhibition assay | Inhibition of human TGBC1TKB cell growth in a cell viability assay. IC50=30.1238 μM | ||||
| A498 | Growth inhibition assay | Inhibition of human A498 cell growth in a cell viability assay. IC50=0.40674 μM | ||||
| AGS | Growth inhibition assay | Inhibition of human AGS cell growth in a cell viability assay. IC50=0.83648 μM | ||||
| U-2-OS | Growth inhibition assay | Inhibition of human U-2-OS cell growth in a cell viability assay. IC50=17.5307 μM | ||||
| U-118-MG | Growth inhibition assay | Inhibition of human U-118-MG cell growth in a cell viability assay. IC50=36.8847 μM | ||||
| U-266 | Growth inhibition assay | Inhibition of human U-266 cell growth in a cell viability assay. IC50=16.2299 μM | ||||
| U031 | Growth inhibition assay | Inhibition of human U031 cell growth in a cell viability assay. IC50=5.25424 μM | ||||
| UACC-257 | Growth inhibition assay | Inhibition of human UACC-257 cell growth in a cell viability assay. IC50=41.7369 μM | ||||
| U-87-MG | Growth inhibition assay | Inhibition of human U-87-MG cell growth in a cell viability assay. IC50=4.10481 μM | ||||
| AsPC-1 | Growth inhibition assay | Inhibition of human AsPC-1 cell growth in a cell viability assay. IC50=19.6471 μM | ||||
| UACC-893 | Growth inhibition assay | Inhibition of human UACC-893 cell growth in a cell viability assay. IC50=0.11885 μM | ||||
| BB30-HNC | Growth inhibition assay | Inhibition of human BB30-HNC cell growth in a cell viability assay. IC50=0.16576 μM | ||||
| UM-UC-3 | Growth inhibition assay | Inhibition of human UM-UC-3 cell growth in a cell viability assay. IC50=9.9503 μM | ||||
| VM-CUB-1 | Growth inhibition assay | Inhibition of human VM-CUB-1 cell growth in a cell viability assay. IC50=4.86819 μM | ||||
| UMC-11 | Growth inhibition assay | Inhibition of human UMC-11 cell growth in a cell viability assay. IC50=26.4514 μM | ||||
| BEN | Growth inhibition assay | Inhibition of human BEN cell growth in a cell viability assay. IC50=27.8517 μM | ||||
| WM-115 | Growth inhibition assay | Inhibition of human WM-115 cell growth in a cell viability assay. IC50=11.7588 μM | ||||
| BFTC-909 | Growth inhibition assay | Inhibition of human BFTC-909 cell growth in a cell viability assay. IC50=9.06799 μM | ||||
| YAPC | Growth inhibition assay | Inhibition of human YAPC cell growth in a cell viability assay. IC50=11.9259 μM | ||||
| BT-20 | Growth inhibition assay | Inhibition of human BT-20 cell growth in a cell viability assay. IC50=3.69795 μM | ||||
| YKG-1 | Growth inhibition assay | Inhibition of human YKG-1 cell growth in a cell viability assay. IC50=1.05419 μM | ||||
| CAPAN-1 | Growth inhibition assay | Inhibition of human CAPAN-1 cell growth in a cell viability assay. IC50=30.5181 μM | ||||
| no-10 | Growth inhibition assay | Inhibition of human no-10 cell growth in a cell viability assay. IC50=16.6343 μM | ||||
| CAMA-1 | Growth inhibition assay | Inhibition of human CAMA-1 cell growth in a cell viability assay. IC50=9.28128 μM | ||||
| CAS-1 | Growth inhibition assay | Inhibition of human CAS-1 cell growth in a cell viability assay. IC50=46.7701 μM | ||||
| BT-549 | Growth inhibition assay | Inhibition of human BT-549 cell growth in a cell viability assay. IC50=6.66889 μM | ||||
| CCRF-CEM | Growth inhibition assay | Inhibition of human CCRF-CEM cell growth in a cell viability assay. IC50=25.967 μM | ||||
| CGTH-W-1 | Growth inhibition assay | Inhibition of human CGTH-W-1 cell growth in a cell viability assay. IC50=42.4955 μM | ||||
| CHP-212 | Growth inhibition assay | Inhibition of human CHP-212 cell growth in a cell viability assay. IC50=22.3222 μM | ||||
| C32 | Growth inhibition assay | Inhibition of human C32 cell growth in a cell viability assay. IC50=9.33064 μM | ||||
| COLO-320-HSR | Growth inhibition assay | Inhibition of human COLO-320-HSR cell growth in a cell viability assay. IC50=18.746 μM | ||||
| CAL-33 | Growth inhibition assay | Inhibition of human CAL-33 cell growth in a cell viability assay. IC50=0.20184 μM | ||||
| COLO-678 | Growth inhibition assay | Inhibition of human COLO-678 cell growth in a cell viability assay. IC50=0.80834 μM | ||||
| COLO-680N | Growth inhibition assay | Inhibition of human COLO-680N cell growth in a cell viability assay. IC50=44.339 μM | ||||
| COLO-684 | Growth inhibition assay | Inhibition of human COLO-684 cell growth in a cell viability assay. IC50=16.9477 μM | ||||
| TE-10 | Growth inhibition assay | Inhibition of human TE-10 cell growth in a cell viability assay. IC50=2.68078 μM | ||||
| COLO-741 | Growth inhibition assay | Inhibition of human COLO-741 cell growth in a cell viability assay. IC50=20.66 μM | ||||
| COLO-792 | Growth inhibition assay | Inhibition of human COLO-792 cell growth in a cell viability assay. IC50=25.2732 μM | ||||
| TE-12 | Growth inhibition assay | Inhibition of human TE-12 cell growth in a cell viability assay. IC50=1.80414 μM | ||||
| COR-L23 | Growth inhibition assay | Inhibition of human COR-L23 cell growth in a cell viability assay. IC50=24.1767 μM | ||||
| COLO-824 | Growth inhibition assay | Inhibition of human COLO-824 cell growth in a cell viability assay. IC50=15.1579 μM | ||||
| COR-L105 | Growth inhibition assay | Inhibition of human COR-L105 cell growth in a cell viability assay. IC50=0.21084 μM | ||||
| COR-L88 | Growth inhibition assay | Inhibition of human COR-L88 cell growth in a cell viability assay. IC50=0.64113 μM | ||||
| TE-8 | Growth inhibition assay | Inhibition of human TE-8 cell growth in a cell viability assay. IC50=1.91377 μM | ||||
| TGBC11TKB | Growth inhibition assay | Inhibition of human TGBC11TKB cell growth in a cell viability assay. IC50=47.1777 μM | ||||
| CP50-MEL-B | Growth inhibition assay | Inhibition of human CP50-MEL-B cell growth in a cell viability assay. IC50=17.0343 μM | ||||
| CP66-MEL | Growth inhibition assay | Inhibition of human CP66-MEL cell growth in a cell viability assay. IC50=15.4688 μM | ||||
| CTB-1 | Growth inhibition assay | Inhibition of human CTB-1 cell growth in a cell viability assay. IC50=4.8488 μM | ||||
| CaR-1 | Growth inhibition assay | Inhibition of human CaR-1 cell growth in a cell viability assay. IC50=2.28281 μM | ||||
| CTV-1 | Growth inhibition assay | Inhibition of human CTV-1 cell growth in a cell viability assay. IC50=0.64392 μM | ||||
| CW-2 | Growth inhibition assay | Inhibition of human CW-2 cell growth in a cell viability assay. IC50=0.46914 μM | ||||
| Ca-Ski | Growth inhibition assay | Inhibition of human Ca-Ski cell growth in a cell viability assay. IC50=7.64259 μM | ||||
| U251 | Growth inhibition assay | Inhibition of human U251 cell growth in a cell viability assay. IC50=40.4054 μM | ||||
| Ca9-22 | Growth inhibition assay | Inhibition of human Ca9-22 cell growth in a cell viability assay. IC50=0.08353 μM | ||||
| Calu-3 | Growth inhibition assay | Inhibition of human Calu-3 cell growth in a cell viability assay. IC50=0.81434 μM | ||||
| Capan-2 | Growth inhibition assay | Inhibition of human Capan-2 cell growth in a cell viability assay. IC50=3.46875 μM | ||||
| UACC-62 | Growth inhibition assay | Inhibition of human UACC-62 cell growth in a cell viability assay. IC50=11.2368 μM | ||||
| ChaGo-K-1 | Growth inhibition assay | Inhibition of human ChaGo-K-1 cell growth in a cell viability assay. IC50=32.007 μM | ||||
| VA-ES-BJ | Growth inhibition assay | Inhibition of human VA-ES-BJ cell growth in a cell viability assay. IC50=35.4648 μM | ||||
| D-263MG | Growth inhibition assay | Inhibition of human D-263MG cell growth in a cell viability assay. IC50=33.8378 μM | ||||
| VMRC-RCZ | Growth inhibition assay | Inhibition of human VMRC-RCZ cell growth in a cell viability assay. IC50=8.01697 μM | ||||
| D-336MG | Growth inhibition assay | Inhibition of human D-336MG cell growth in a cell viability assay. IC50=30.2892 μM | ||||
| D-392MG | Growth inhibition assay | Inhibition of human D-392MG cell growth in a cell viability assay. IC50=35.0565 μM | ||||
| D-566MG | Growth inhibition assay | Inhibition of human D-566MG cell growth in a cell viability assay. IC50=29.9393 μM | ||||
| D-423MG | Growth inhibition assay | Inhibition of human D-423MG cell growth in a cell viability assay. IC50=5.61705 μM | ||||
| DBTRG-05MG | Growth inhibition assay | Inhibition of human DBTRG-05MG cell growth in a cell viability assay. IC50=13.0633 μM | ||||
| D-502MG | Growth inhibition assay | Inhibition of human D-502MG cell growth in a cell viability assay. IC50=8.29282 μM | ||||
| ZR-75-30 | Growth inhibition assay | Inhibition of human ZR-75-30 cell growth in a cell viability assay. IC50=0.09545 μM | ||||
| D-542MG | Growth inhibition assay | Inhibition of human D-542MG cell growth in a cell viability assay. IC50=1.01064 μM | ||||
| DMS-273 | Growth inhibition assay | Inhibition of human DMS-273 cell growth in a cell viability assay. IC50=32.5322 μM | ||||
| DJM-1 | Growth inhibition assay | Inhibition of human DJM-1 cell growth in a cell viability assay. IC50=6.92012 μM | ||||
| DK-MG | Growth inhibition assay | Inhibition of human DK-MG cell growth in a cell viability assay. IC50=30.5456 μM | ||||
| no-11 | Growth inhibition assay | Inhibition of human no-11 cell growth in a cell viability assay. IC50=3.53564 μM | ||||
| DMS-114 | Growth inhibition assay | Inhibition of human DMS-114 cell growth in a cell viability assay. IC50=40.8374 μM | ||||
| DMS-79 | Growth inhibition assay | Inhibition of human DMS-79 cell growth in a cell viability assay. IC50=40.5889 μM | ||||
| DOK | Growth inhibition assay | Inhibition of human DOK cell growth in a cell viability assay. IC50=0.03194 μM | ||||
| CFPAC-1 | Growth inhibition assay | Inhibition of human CFPAC-1 cell growth in a cell viability assay. IC50=1.42493 μM | ||||
| DSH1 | Growth inhibition assay | Inhibition of human DSH1 cell growth in a cell viability assay. IC50=0.03314 μM | ||||
| DU-145 | Growth inhibition assay | Inhibition of human DU-145 cell growth in a cell viability assay. IC50=0.44833 μM | ||||
| CHL-1 | Growth inhibition assay | Inhibition of human CHL-1 cell growth in a cell viability assay. IC50=0.01839 μM | ||||
| DU-4475 | Growth inhibition assay | Inhibition of human DU-4475 cell growth in a cell viability assay. IC50=1.40121 μM | ||||
| DoTc2-4510 | Growth inhibition assay | Inhibition of human DoTc2-4510 cell growth in a cell viability assay. IC50=0.32219 μM | ||||
| Daoy | Growth inhibition assay | Inhibition of human Daoy cell growth in a cell viability assay. IC50=24.126 μM | ||||
| Detroit562 | Growth inhibition assay | Inhibition of human Detroit562 cell growth in a cell viability assay. IC50=1.70152 μM | ||||
| ECC10 | Growth inhibition assay | Inhibition of human ECC10 cell growth in a cell viability assay. IC50=1.55369 μM | ||||
| EC-GI-10 | Growth inhibition assay | Inhibition of human EC-GI-10 cell growth in a cell viability assay. IC50=0.05912 μM | ||||
| EFM-19 | Growth inhibition assay | Inhibition of human EFM-19 cell growth in a cell viability assay. IC50=37.7967 μM | ||||
| COLO-679 | Growth inhibition assay | Inhibition of human COLO-679 cell growth in a cell viability assay. IC50=35.388 μM | ||||
| EFO-21 | Growth inhibition assay | Inhibition of human EFO-21 cell growth in a cell viability assay. IC50=11.1045 μM | ||||
| EFO-27 | Growth inhibition assay | Inhibition of human EFO-27 cell growth in a cell viability assay. IC50=0.05182 μM | ||||
| EKVX | Growth inhibition assay | Inhibition of human EKVX cell growth in a cell viability assay. IC50=1.01064 μM | ||||
| EGI-1 | Growth inhibition assay | Inhibition of human EGI-1 cell growth in a cell viability assay. IC50=28.5928 μM | ||||
| EPLC-272H | Growth inhibition assay | Inhibition of human EPLC-272H cell growth in a cell viability assay. IC50=4.41533 μM | ||||
| COLO-800 | Growth inhibition assay | Inhibition of human COLO-800 cell growth in a cell viability assay. IC50=7.41446 μM | ||||
| COLO-829 | Growth inhibition assay | Inhibition of human COLO-829 cell growth in a cell viability assay. IC50=8.80976 μM | ||||
| ES3 | Growth inhibition assay | Inhibition of human ES3 cell growth in a cell viability assay. IC50=16.9134 μM | ||||
| ES8 | Growth inhibition assay | Inhibition of human ES8 cell growth in a cell viability assay. IC50=17.6087 μM | ||||
| ES4 | Growth inhibition assay | Inhibition of human ES4 cell growth in a cell viability assay. IC50=0.97836 μM | ||||
| ETK-1 | Growth inhibition assay | Inhibition of human ETK-1 cell growth in a cell viability assay. IC50=1.37456 μM | ||||
| EW-1 | Growth inhibition assay | Inhibition of human EW-1 cell growth in a cell viability assay. IC50=45.9689 μM | ||||
| ES5 | Growth inhibition assay | Inhibition of human ES5 cell growth in a cell viability assay. IC50=4.83723 μM | ||||
| EW-11 | Growth inhibition assay | Inhibition of human EW-11 cell growth in a cell viability assay. IC50=9.17653 μM | ||||
| EW-13 | Growth inhibition assay | Inhibition of human EW-13 cell growth in a cell viability assay. IC50=14.0352 μM | ||||
| EW-18 | Growth inhibition assay | Inhibition of human EW-18 cell growth in a cell viability assay. IC50=0.68698 μM | ||||
| EW-3 | Growth inhibition assay | Inhibition of human EW-3 cell growth in a cell viability assay. IC50=1.07883 μM | ||||
| EW-24 | Growth inhibition assay | Inhibition of human EW-24 cell growth in a cell viability assay. IC50=21.3945 μM | ||||
| Calu-6 | Growth inhibition assay | Inhibition of human Calu-6 cell growth in a cell viability assay. IC50=30.2963 μM | ||||
| FTC-133 | Growth inhibition assay | Inhibition of human FTC-133 cell growth in a cell viability assay. IC50=11.1407 μM | ||||
| EoL-1-cell | Growth inhibition assay | Inhibition of human EoL-1-cell cell growth in a cell viability assay. IC50=0.26892 μM | ||||
| FADU | Growth inhibition assay | Inhibition of human FADU cell growth in a cell viability assay. IC50=0.54404 μM | ||||
| G-401 | Growth inhibition assay | Inhibition of human G-401 cell growth in a cell viability assay. IC50=1.67413 μM | ||||
| GAK | Growth inhibition assay | Inhibition of human GAK cell growth in a cell viability assay. IC50=25.2963 μM | ||||
| GAMG | Growth inhibition assay | Inhibition of human GAMG cell growth in a cell viability assay. IC50=3.91314 μM | ||||
| GMS-10 | Growth inhibition assay | Inhibition of human GMS-10 cell growth in a cell viability assay. IC50=2.03517 μM | ||||
| GB-1 | Growth inhibition assay | Inhibition of human GB-1 cell growth in a cell viability assay. IC50=25.4068 μM | ||||
| GI-ME-N | Growth inhibition assay | Inhibition of human GI-ME-N cell growth in a cell viability assay. IC50=31.0571 μM | ||||
| GOTO | Growth inhibition assay | Inhibition of human GOTO cell growth in a cell viability assay. IC50=31.8506 μM | ||||
| GCIY | Growth inhibition assay | Inhibition of human GCIY cell growth in a cell viability assay. IC50=1.08104 μM | ||||
| GT3TKB | Growth inhibition assay | Inhibition of human GT3TKB cell growth in a cell viability assay. IC50=8.67964 μM | ||||
| GP5d | Growth inhibition assay | Inhibition of human GP5d cell growth in a cell viability assay. IC50=6.97394 μM | ||||
| D-283MED | Growth inhibition assay | Inhibition of human D-283MED cell growth in a cell viability assay. IC50=18.0088 μM | ||||
| GR-ST | Growth inhibition assay | Inhibition of human GR-ST cell growth in a cell viability assay. IC50=28.6696 μM | ||||
| DB | Growth inhibition assay | Inhibition of human DB cell growth in a cell viability assay. IC50=7.61005 μM | ||||
| HC-1 | Growth inhibition assay | Inhibition of human HC-1 cell growth in a cell viability assay. IC50=5.51839 μM | ||||
| HAL-01 | Growth inhibition assay | Inhibition of human HAL-01 cell growth in a cell viability assay. IC50=8.5191 μM | ||||
| HCC1187 | Growth inhibition assay | Inhibition of human HCC1187 cell growth in a cell viability assay. IC50=20.6734 μM | ||||
| HCC1419 | Growth inhibition assay | Inhibition of human HCC1419 cell growth in a cell viability assay. IC50=0.36408 μM | ||||
| HCC1395 | Growth inhibition assay | Inhibition of human HCC1395 cell growth in a cell viability assay. IC50=14.9338 μM | ||||
| DEL | Growth inhibition assay | Inhibition of human DEL cell growth in a cell viability assay. IC50=10.3946 μM | ||||
| DOHH-2 | Growth inhibition assay | Inhibition of human DOHH-2 cell growth in a cell viability assay. IC50=20.5463 μM | ||||
| HCC1937 | Growth inhibition assay | Inhibition of human HCC1937 cell growth in a cell viability assay. IC50=12.7564 μM | ||||
| HCC38 | Growth inhibition assay | Inhibition of human HCC38 cell growth in a cell viability assay. IC50=42.9618 μM | ||||
| HCC1954 | Growth inhibition assay | Inhibition of human HCC1954 cell growth in a cell viability assay. IC50=11.0754 μM | ||||
| HCC2218 | Growth inhibition assay | Inhibition of human HCC2218 cell growth in a cell viability assay. IC50=0.009869 μM | ||||
| HCE-4 | Growth inhibition assay | Inhibition of human HCE-4 cell growth in a cell viability assay. IC50=9.21558 μM | ||||
| HCE-T | Growth inhibition assay | Inhibition of human HCE-T cell growth in a cell viability assay. IC50=0.88428 μM | ||||
| HL-60 | Growth inhibition assay | Inhibition of human HL-60 cell growth in a cell viability assay. IC50=4.86611 μM | ||||
| HCT-116 | Growth inhibition assay | Inhibition of human HCT-116 cell growth in a cell viability assay. IC50=4.41007 μM | ||||
| HEL | Growth inhibition assay | Inhibition of human HEL cell growth in a cell viability assay. IC50=7.71203 μM | ||||
| HCT-15 | Growth inhibition assay | Inhibition of human HCT-15 cell growth in a cell viability assay. IC50=22.7441 μM | ||||
| HLE | Growth inhibition assay | Inhibition of human HLE cell growth in a cell viability assay. IC50=0.35046 μM | ||||
| HH | Growth inhibition assay | Inhibition of human HH cell growth in a cell viability assay. IC50=16.5162 μM | ||||
| HD-MY-Z | Growth inhibition assay | Inhibition of human HD-MY-Z cell growth in a cell viability assay. IC50=48.786 μM | ||||
| HO-1-N-1 | Growth inhibition assay | Inhibition of human HO-1-N-1 cell growth in a cell viability assay. IC50=0.27853 μM | ||||
| HN | Growth inhibition assay | Inhibition of human HN cell growth in a cell viability assay. IC50=0.13077 μM | ||||
| HDLM-2 | Growth inhibition assay | Inhibition of human HDLM-2 cell growth in a cell viability assay. IC50=0.00572 μM | ||||
| EM-2 | Growth inhibition assay | Inhibition of human EM-2 cell growth in a cell viability assay. IC50=14.8576 μM | ||||
| HOP-92 | Growth inhibition assay | Inhibition of human HOP-92 cell growth in a cell viability assay. IC50=26.1226 μM | ||||
| HPAF-II | Growth inhibition assay | Inhibition of human HPAF-II cell growth in a cell viability assay. IC50=41.6709 μM | ||||
| HSC-2 | Growth inhibition assay | Inhibition of human HSC-2 cell growth in a cell viability assay. IC50=0.16837 μM | ||||
| ES1 | Growth inhibition assay | Inhibition of human ES1 cell growth in a cell viability assay. IC50=19.9213 μM | ||||
| HSC-3 | Growth inhibition assay | Inhibition of human HSC-3 cell growth in a cell viability assay. IC50=0.21198 μM | ||||
| HSC-4 | Growth inhibition assay | Inhibition of human HSC-4 cell growth in a cell viability assay. IC50=0.01748 μM | ||||
| ES7 | Growth inhibition assay | Inhibition of human ES7 cell growth in a cell viability assay. IC50=19.6292 μM | ||||
| HT-144 | Growth inhibition assay | Inhibition of human HT-144 cell growth in a cell viability assay. IC50=27.4032 μM | ||||
| ESS-1 | Growth inhibition assay | Inhibition of human ESS-1 cell growth in a cell viability assay. IC50=18.5206 μM | ||||
| HT-29 | Growth inhibition assay | Inhibition of human HT-29 cell growth in a cell viability assay. IC50=3.07309 μM | ||||
| HT-3 | Growth inhibition assay | Inhibition of human HT-3 cell growth in a cell viability assay. IC50=1.28753 μM | ||||
| HT55 | Growth inhibition assay | Inhibition of human HT55 cell growth in a cell viability assay. IC50=2.5738 μM | ||||
| EW-16 | Growth inhibition assay | Inhibition of human EW-16 cell growth in a cell viability assay. IC50=27.2947 μM | ||||
| HTC-C3 | Growth inhibition assay | Inhibition of human HTC-C3 cell growth in a cell viability assay. IC50=27.2561 μM | ||||
| HT-1376 | Growth inhibition assay | Inhibition of human HT-1376 cell growth in a cell viability assay. IC50=1.01513 μM | ||||
| EW-22 | Growth inhibition assay | Inhibition of human EW-22 cell growth in a cell viability assay. IC50=41.8697 μM | ||||
| Hs-578-T | Growth inhibition assay | Inhibition of human Hs-578-T cell growth in a cell viability assay. IC50=45.0294 μM | ||||
| G-361 | Growth inhibition assay | Inhibition of human G-361 cell growth in a cell viability assay. IC50=26.1027 μM | ||||
| HuH-7 | Growth inhibition assay | Inhibition of human HuH-7 cell growth in a cell viability assay. IC50=28.4028 μM | ||||
| HuO-3N1 | Growth inhibition assay | Inhibition of human HuO-3N1 cell growth in a cell viability assay. IC50=5.24043 μM | ||||
| HuO9 | Growth inhibition assay | Inhibition of human HuO9 cell growth in a cell viability assay. IC50=11.8774 μM | ||||
| G-402 | Growth inhibition assay | Inhibition of human G-402 cell growth in a cell viability assay. IC50=35.9867 μM | ||||
| IGROV-1 | Growth inhibition assay | Inhibition of human IGROV-1 cell growth in a cell viability assay. IC50=0.25952 μM | ||||
| HuP-T3 | Growth inhibition assay | Inhibition of human HuP-T3 cell growth in a cell viability assay. IC50=16.6576 μM | ||||
| HuP-T4 | Growth inhibition assay | Inhibition of human HuP-T4 cell growth in a cell viability assay. IC50=0.6976 μM | ||||
| GCT | Growth inhibition assay | Inhibition of human GCT cell growth in a cell viability assay. IC50=20.3026 μM | ||||
| IST-MEL1 | Growth inhibition assay | Inhibition of human IST-MEL1 cell growth in a cell viability assay. IC50=11.456 μM | ||||
| GI-1 | Growth inhibition assay | Inhibition of human GI-1 cell growth in a cell viability assay. IC50=22.7658 μM | ||||
| IST-MES1 | Growth inhibition assay | Inhibition of human IST-MES1 cell growth in a cell viability assay. IC50=18.4428 μM | ||||
| J82 | Growth inhibition assay | Inhibition of human J82 cell growth in a cell viability assay. IC50=15.057 μM | ||||
| JAR | Growth inhibition assay | Inhibition of human JAR cell growth in a cell viability assay. IC50=19.299 μM | ||||
| H-EMC-SS | Growth inhibition assay | Inhibition of human H-EMC-SS cell growth in a cell viability assay. IC50=32.9678 μM | ||||
| JEG-3 | Growth inhibition assay | Inhibition of human JEG-3 cell growth in a cell viability assay. IC50=22.378 μM | ||||
| JVM-2 | Growth inhibition assay | Inhibition of human JVM-2 cell growth in a cell viability assay. IC50=0.88299 μM | ||||
| H9 | Growth inhibition assay | Inhibition of human H9 cell growth in a cell viability assay. IC50=0.07132 μM | ||||
| KARPAS-299 | Growth inhibition assay | Inhibition of human KARPAS-299 cell growth in a cell viability assay. IC50=20.3422 μM | ||||
| JVM-3 | Growth inhibition assay | Inhibition of human JVM-3 cell growth in a cell viability assay. IC50=7.89599 μM | ||||
| KALS-1 | Growth inhibition assay | Inhibition of human KALS-1 cell growth in a cell viability assay. IC50=23.1414 μM | ||||
| HCC1569 | Growth inhibition assay | Inhibition of human HCC1569 cell growth in a cell viability assay. IC50=2.58297 μM | ||||
| KARPAS-45 | Growth inhibition assay | Inhibition of human KARPAS-45 cell growth in a cell viability assay. IC50=0.01671 μM | ||||
| KE-37 | Growth inhibition assay | Inhibition of human KE-37 cell growth in a cell viability assay. IC50=25.7315 μM | ||||
| KASUMI-1 | Growth inhibition assay | Inhibition of human KASUMI-1 cell growth in a cell viability assay. IC50=0.00911 μM | ||||
| KGN | Growth inhibition assay | Inhibition of human KGN cell growth in a cell viability assay. IC50=32.633 μM | ||||
| KLE | Growth inhibition assay | Inhibition of human KLE cell growth in a cell viability assay. IC50=4.40819 μM | ||||
| HCC1806 | Growth inhibition assay | Inhibition of human HCC1806 cell growth in a cell viability assay. IC50=0.69666 μM | ||||
| KM-H2 | Growth inhibition assay | Inhibition of human KM-H2 cell growth in a cell viability assay. IC50=34.1779 μM | ||||
| KM12 | Growth inhibition assay | Inhibition of human KM12 cell growth in a cell viability assay. IC50=22.356 μM | ||||
| HCC2998 | Growth inhibition assay | Inhibition of human HCC2998 cell growth in a cell viability assay. IC50=5.52615 μM | ||||
| KNS-42 | Growth inhibition assay | Inhibition of human KNS-42 cell growth in a cell viability assay. IC50=35.5826 μM | ||||
| KMOE-2 | Growth inhibition assay | Inhibition of human KMOE-2 cell growth in a cell viability assay. IC50=19.2242 μM | ||||
| HCC70 | Growth inhibition assay | Inhibition of human HCC70 cell growth in a cell viability assay. IC50=0.57661 μM | ||||
| HEC-1 | Growth inhibition assay | Inhibition of human HEC-1 cell growth in a cell viability assay. IC50=3.5895 μM | ||||
| KP-4 | Growth inhibition assay | Inhibition of human KP-4 cell growth in a cell viability assay. IC50=42.8832 μM | ||||
| KNS-81-FD | Growth inhibition assay | Inhibition of human KNS-81-FD cell growth in a cell viability assay. IC50=19.5468 μM | ||||
| HGC-27 | Growth inhibition assay | Inhibition of human HGC-27 cell growth in a cell viability assay. IC50=31.5873 μM | ||||
| KP-N-YN | Growth inhibition assay | Inhibition of human KP-N-YN cell growth in a cell viability assay. IC50=37.6195 μM | ||||
| KP-N-YS | Growth inhibition assay | Inhibition of human KP-N-YS cell growth in a cell viability assay. IC50=40.6768 μM | ||||
| KU-19-19 | Growth inhibition assay | Inhibition of human KU-19-19 cell growth in a cell viability assay. IC50=0.77464 μM | ||||
| HOP-62 | Growth inhibition assay | Inhibition of human HOP-62 cell growth in a cell viability assay. IC50=11.6764 μM | ||||
| HOS | Growth inhibition assay | Inhibition of human HOS cell growth in a cell viability assay. IC50=39.6273 μM | ||||
| KURAMOCHI | Growth inhibition assay | Inhibition of human KURAMOCHI cell growth in a cell viability assay. IC50=7.94811 μM | ||||
| KY821 | Growth inhibition assay | Inhibition of human KY821 cell growth in a cell viability assay. IC50=0.0206 μM | ||||
| KYSE-270 | Growth inhibition assay | Inhibition of human KYSE-270 cell growth in a cell viability assay. IC50=2.02732 μM | ||||
| KYSE-140 | Growth inhibition assay | Inhibition of human KYSE-140 cell growth in a cell viability assay. IC50=0.0833 μM | ||||
| KYSE-150 | Growth inhibition assay | Inhibition of human KYSE-150 cell growth in a cell viability assay. IC50=42.1782 μM | ||||
| KYSE-450 | Growth inhibition assay | Inhibition of human KYSE-450 cell growth in a cell viability assay. IC50=0.05978 μM | ||||
| HT | Growth inhibition assay | Inhibition of human HT cell growth in a cell viability assay. IC50=40.6639 μM | ||||
| KYSE-180 | Growth inhibition assay | Inhibition of human KYSE-180 cell growth in a cell viability assay. IC50=0.39089 μM | ||||
| HT-1197 | Growth inhibition assay | Inhibition of human HT-1197 cell growth in a cell viability assay. IC50=4.52669 μM | ||||
| KYSE-520 | Growth inhibition assay | Inhibition of human KYSE-520 cell growth in a cell viability assay. IC50=5.20839 μM | ||||
| KYSE-70 | Growth inhibition assay | Inhibition of human KYSE-70 cell growth in a cell viability assay. IC50=30.5114 μM | ||||
| HUTU-80 | Growth inhibition assay | Inhibition of human HUTU-80 cell growth in a cell viability assay. IC50=41.0569 μM | ||||
| L-363 | Growth inhibition assay | Inhibition of human L-363 cell growth in a cell viability assay. IC50=16.4577 μM | ||||
| L-428 | Growth inhibition assay | Inhibition of human L-428 cell growth in a cell viability assay. IC50=24.5791 μM | ||||
| LAMA-84 | Growth inhibition assay | Inhibition of human LAMA-84 cell growth in a cell viability assay. IC50=4.1702 μM | ||||
| HuCCT1 | Growth inhibition assay | Inhibition of human HuCCT1 cell growth in a cell viability assay. IC50=10.6034 μM | ||||
| LB1047-RCC | Growth inhibition assay | Inhibition of human LB1047-RCC cell growth in a cell viability assay. IC50=2.74888 μM | ||||
| IGR-1 | Growth inhibition assay | Inhibition of human IGR-1 cell growth in a cell viability assay. IC50=28.8874 μM | ||||
| LB2518-MEL | Growth inhibition assay | Inhibition of human LB2518-MEL cell growth in a cell viability assay. IC50=49.8723 μM | ||||
| LB373-MEL-D | Growth inhibition assay | Inhibition of human LB373-MEL-D cell growth in a cell viability assay. IC50=7.76771 μM | ||||
| LB771-HNC | Growth inhibition assay | Inhibition of human LB771-HNC cell growth in a cell viability assay. IC50=35.1658 μM | ||||
| IST-SL1 | Growth inhibition assay | Inhibition of human IST-SL1 cell growth in a cell viability assay. IC50=26.6591 μM | ||||
| LCLC-103H | Growth inhibition assay | Inhibition of human LCLC-103H cell growth in a cell viability assay. IC50=36.7803 μM | ||||
| LC-2-ad | Growth inhibition assay | Inhibition of human LC-2-ad cell growth in a cell viability assay. IC50=21.2729 μM | ||||
| LCLC-97TM1 | Growth inhibition assay | Inhibition of human LCLC-97TM1 cell growth in a cell viability assay. IC50=4.53686 μM | ||||
| LN-405 | Growth inhibition assay | Inhibition of human LN-405 cell growth in a cell viability assay. IC50=22.5913 μM | ||||
| LK-2 | Growth inhibition assay | Inhibition of human LK-2 cell growth in a cell viability assay. IC50=13.7639 μM | ||||
| J-RT3-T3-5 | Growth inhibition assay | Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay. IC50=6.869 μM | ||||
| LS-1034 | Growth inhibition assay | Inhibition of human LS-1034 cell growth in a cell viability assay. IC50=6.20706 μM | ||||
| LS-123 | Growth inhibition assay | Inhibition of human LS-123 cell growth in a cell viability assay. IC50=3.74284 μM | ||||
| K5 | Growth inhibition assay | Inhibition of human K5 cell growth in a cell viability assay. IC50=1.58357 μM | ||||
| LS-411N | Growth inhibition assay | Inhibition of human LS-411N cell growth in a cell viability assay. IC50=5.79441 μM | ||||
| LU-134-A | Growth inhibition assay | Inhibition of human LU-134-A cell growth in a cell viability assay. IC50=21.1026 μM | ||||
| KG-1 | Growth inhibition assay | Inhibition of human KG-1 cell growth in a cell viability assay. IC50=24.1928 μM | ||||
| KINGS-1 | Growth inhibition assay | Inhibition of human KINGS-1 cell growth in a cell viability assay. IC50=5.60944 μM | ||||
| LU-65 | Growth inhibition assay | Inhibition of human LU-65 cell growth in a cell viability assay. IC50=0.12633 μM | ||||
| LU-139 | Growth inhibition assay | Inhibition of human LU-139 cell growth in a cell viability assay. IC50=0.3051 μM | ||||
| LU-99A | Growth inhibition assay | Inhibition of human LU-99A cell growth in a cell viability assay. IC50=37.5731 μM | ||||
| LXF-289 | Growth inhibition assay | Inhibition of human LXF-289 cell growth in a cell viability assay. IC50=2.63565 μM | ||||
| M14 | Growth inhibition assay | Inhibition of human M14 cell growth in a cell viability assay. IC50=44.1332 μM | ||||
| KNS-62 | Growth inhibition assay | Inhibition of human KNS-62 cell growth in a cell viability assay. IC50=3.94731 μM | ||||
| LoVo | Growth inhibition assay | Inhibition of human LoVo cell growth in a cell viability assay. IC50=2.10797 μM | ||||
| KOSC-2 | Growth inhibition assay | Inhibition of human KOSC-2 cell growth in a cell viability assay. IC50=3.83451 μM | ||||
| MC-IXC | Growth inhibition assay | Inhibition of human MC-IXC cell growth in a cell viability assay. IC50=11.6728 μM | ||||
| MC116 | Growth inhibition assay | Inhibition of human MC116 cell growth in a cell viability assay. IC50=3.95489 μM | ||||
| MDA-MB-175-VII | Growth inhibition assay | Inhibition of human MDA-MB-175-VII cell growth in a cell viability assay. IC50=0.03416 μM | ||||
| MCF7 | Growth inhibition assay | Inhibition of human MCF7 cell growth in a cell viability assay. IC50=16.4723 μM | ||||
| MDA-MB-361 | Growth inhibition assay | Inhibition of human MDA-MB-361 cell growth in a cell viability assay. IC50=0.72662 μM | ||||
| KS-1 | Growth inhibition assay | Inhibition of human KS-1 cell growth in a cell viability assay. IC50=4.50889 μM | ||||
| MDA-MB-157 | Growth inhibition assay | Inhibition of human MDA-MB-157 cell growth in a cell viability assay. IC50=2.21828 μM | ||||
| MDA-MB-453 | Growth inhibition assay | Inhibition of human MDA-MB-453 cell growth in a cell viability assay. IC50=11.9515 μM | ||||
| KU812 | Growth inhibition assay | Inhibition of human KU812 cell growth in a cell viability assay. IC50=0.15456 μM | ||||
| ME-180 | Growth inhibition assay | Inhibition of human ME-180 cell growth in a cell viability assay. IC50=1.61096 μM | ||||
| MEG-01 | Growth inhibition assay | Inhibition of human MEG-01 cell growth in a cell viability assay. IC50=4.99403 μM | ||||
| KYSE-410 | Growth inhibition assay | Inhibition of human KYSE-410 cell growth in a cell viability assay. IC50=1.65672 μM | ||||
| MEL-HO | Growth inhibition assay | Inhibition of human MEL-HO cell growth in a cell viability assay. IC50=30.1423 μM | ||||
| MFE-280 | Growth inhibition assay | Inhibition of human MFE-280 cell growth in a cell viability assay. IC50=16.0488 μM | ||||
| MFH-ino | Growth inhibition assay | Inhibition of human MFH-ino cell growth in a cell viability assay. IC50=37.3371 μM | ||||
| KYSE-510 | Growth inhibition assay | Inhibition of human KYSE-510 cell growth in a cell viability assay. IC50=19.8748 μM | ||||
| MFM-223 | Growth inhibition assay | Inhibition of human MFM-223 cell growth in a cell viability assay. IC50=16.3965 μM | ||||
| MG-63 | Growth inhibition assay | Inhibition of human MG-63 cell growth in a cell viability assay. IC50=5.48762 μM | ||||
| MHH-NB-11 | Growth inhibition assay | Inhibition of human MHH-NB-11 cell growth in a cell viability assay. IC50=16.0839 μM | ||||
| LAN-6 | Growth inhibition assay | Inhibition of human LAN-6 cell growth in a cell viability assay. IC50=40.0112 μM | ||||
| MKN1 | Growth inhibition assay | Inhibition of human MKN1 cell growth in a cell viability assay. IC50=3.47108 μM | ||||
| MIA-PaCa-2 | Growth inhibition assay | Inhibition of human MIA-PaCa-2 cell growth in a cell viability assay. IC50=28.7959 μM | ||||
| MKN28 | Growth inhibition assay | Inhibition of human MKN28 cell growth in a cell viability assay. IC50=32.7838 μM | ||||
| ML-2 | Growth inhibition assay | Inhibition of human ML-2 cell growth in a cell viability assay. IC50=0.24802 μM | ||||
| MKN45 | Growth inhibition assay | Inhibition of human MKN45 cell growth in a cell viability assay. IC50=21.1551 μM | ||||
| MMAC-SF | Growth inhibition assay | Inhibition of human MMAC-SF cell growth in a cell viability assay. IC50=19.2607 μM | ||||
| MKN7 | Growth inhibition assay | Inhibition of human MKN7 cell growth in a cell viability assay. IC50=2.35335 μM | ||||
| LB2241-RCC | Growth inhibition assay | Inhibition of human LB2241-RCC cell growth in a cell viability assay. IC50=0.10884 μM | ||||
| LB831-BLC | Growth inhibition assay | Inhibition of human LB831-BLC cell growth in a cell viability assay. IC50=38.6039 μM | ||||
| MOLT-13 | Growth inhibition assay | Inhibition of human MOLT-13 cell growth in a cell viability assay. IC50=0.23975 μM | ||||
| MSTO-211H | Growth inhibition assay | Inhibition of human MSTO-211H cell growth in a cell viability assay. IC50=45.9482 μM | ||||
| MOLT-16 | Growth inhibition assay | Inhibition of human MOLT-16 cell growth in a cell viability assay. IC50=17.8935 μM | ||||
| MOLT-4 | Growth inhibition assay | Inhibition of human MOLT-4 cell growth in a cell viability assay. IC50=7.02135 μM | ||||
| MZ1-PC | Growth inhibition assay | Inhibition of human MZ1-PC cell growth in a cell viability assay. IC50=30.393 μM | ||||
| MZ2-MEL | Growth inhibition assay | Inhibition of human MZ2-MEL cell growth in a cell viability assay. IC50=16.8403 μM | ||||
| MPP-89 | Growth inhibition assay | Inhibition of human MPP-89 cell growth in a cell viability assay. IC50=22.8661 μM | ||||
| MZ7-mel | Growth inhibition assay | Inhibition of human MZ7-mel cell growth in a cell viability assay. IC50=34.6487 μM | ||||
| LNCaP-Clone-FGC | Growth inhibition assay | Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay. IC50=15.4248 μM | ||||
| Mewo | Growth inhibition assay | Inhibition of human Mewo cell growth in a cell viability assay. IC50=34.1349 μM | ||||
| LOXIMVI | Growth inhibition assay | Inhibition of human LOXIMVI cell growth in a cell viability assay. IC50=5.63873 μM | ||||
| NB12 | Growth inhibition assay | Inhibition of human NB12 cell growth in a cell viability assay. IC50=25.2947 μM | ||||
| NB10 | Growth inhibition assay | Inhibition of human NB10 cell growth in a cell viability assay. IC50=22.2371 μM | ||||
| NB13 | Growth inhibition assay | Inhibition of human NB13 cell growth in a cell viability assay. IC50=42.6217 μM | ||||
| NB5 | Growth inhibition assay | Inhibition of human NB5 cell growth in a cell viability assay. IC50=1.41317 μM | ||||
| NB14 | Growth inhibition assay | Inhibition of human NB14 cell growth in a cell viability assay. IC50=6.43836 μM | ||||
| LS-513 | Growth inhibition assay | Inhibition of human LS-513 cell growth in a cell viability assay. IC50=4.31217 μM | ||||
| NB17 | Growth inhibition assay | Inhibition of human NB17 cell growth in a cell viability assay. IC50=31.5185 μM | ||||
| NB69 | Growth inhibition assay | Inhibition of human NB69 cell growth in a cell viability assay. IC50=1.02945 μM | ||||
| NCI-H1048 | Growth inhibition assay | Inhibition of human NCI-H1048 cell growth in a cell viability assay. IC50=2.49158 μM | ||||
| NBsusSR | Growth inhibition assay | Inhibition of human NBsusSR cell growth in a cell viability assay. IC50=3.18254 μM | ||||
| LU-135 | Growth inhibition assay | Inhibition of human LU-135 cell growth in a cell viability assay. IC50=33.8829 μM | ||||
| NCI-H1092 | Growth inhibition assay | Inhibition of human NCI-H1092 cell growth in a cell viability assay. IC50=16.8316 μM | ||||
| NCI-H1155 | Growth inhibition assay | Inhibition of human NCI-H1155 cell growth in a cell viability assay. IC50=19.7238 μM | ||||
| NCI-H1304 | Growth inhibition assay | Inhibition of human NCI-H1304 cell growth in a cell viability assay. IC50=26.9108 μM | ||||
| NCI-H1395 | Growth inhibition assay | Inhibition of human NCI-H1395 cell growth in a cell viability assay. IC50=20.6697 μM | ||||
| NCI-H1437 | Growth inhibition assay | Inhibition of human NCI-H1437 cell growth in a cell viability assay. IC50=18.1641 μM | ||||
| MDA-MB-231 | Growth inhibition assay | Inhibition of human MDA-MB-231 cell growth in a cell viability assay. IC50=28.2795 μM | ||||
| MDA-MB-415 | Growth inhibition assay | Inhibition of human MDA-MB-415 cell growth in a cell viability assay. IC50=23.9498 μM | ||||
| MHH-ES-1 | Growth inhibition assay | Inhibition of human MHH-ES-1 cell growth in a cell viability assay. IC50=27.4447 μM | ||||
| MHH-PREB-1 | Growth inhibition assay | Inhibition of human MHH-PREB-1 cell growth in a cell viability assay. IC50=10.1999 μM | ||||
| MLMA | Growth inhibition assay | Inhibition of human MLMA cell growth in a cell viability assay. IC50=22.747 μM | ||||
| MN-60 | Growth inhibition assay | Inhibition of human MN-60 cell growth in a cell viability assay. IC50=7.28089 μM | ||||
| MS-1 | Growth inhibition assay | Inhibition of human MS-1 cell growth in a cell viability assay. IC50=30.8889 μM | ||||
| MV-4-11 | Growth inhibition assay | Inhibition of human MV-4-11 cell growth in a cell viability assay. IC50=3.87994 μM | ||||
| Mo-T | Growth inhibition assay | Inhibition of human Mo-T cell growth in a cell viability assay. IC50=18.8204 μM | ||||
| NB7 | Growth inhibition assay | Inhibition of human NB7 cell growth in a cell viability assay. IC50=2.29676 μM | ||||
| NCI-H1299 | Growth inhibition assay | Inhibition of human NCI-H1299 cell growth in a cell viability assay. IC50=6.63171 μM | ||||
| NCI-H1355 | Growth inhibition assay | Inhibition of human NCI-H1355 cell growth in a cell viability assay. IC50=34.3889 μM | ||||
| NCI-H1792 | Growth inhibition assay | Inhibition of human NCI-H1792 cell growth in a cell viability assay. IC50=50.2744 μM | ||||
| NCI-H2347 | Growth inhibition assay | Inhibition of human NCI-H2347 cell growth in a cell viability assay. IC50=58.3648 μM | ||||
| NCI-H2452 | Growth inhibition assay | Inhibition of human NCI-H2452 cell growth in a cell viability assay. IC50=56.5819 μM | ||||
| PSN1 | Growth inhibition assay | Inhibition of human PSN1 cell growth in a cell viability assay. IC50=50.9394 μM | ||||
| RH-1 | Growth inhibition assay | Inhibition of human RH-1 cell growth in a cell viability assay. IC50=66.3277 μM | ||||
| SK-LMS-1 | Growth inhibition assay | Inhibition of human SK-LMS-1 cell growth in a cell viability assay. IC50=51.9815 μM | ||||
| SK-MEL-30 | Growth inhibition assay | Inhibition of human SK-MEL-30 cell growth in a cell viability assay. IC50=133.481 μM | ||||
| SNB75 | Growth inhibition assay | Inhibition of human SNB75 cell growth in a cell viability assay. IC50=50.414 μM | ||||
| SNU-423 | Growth inhibition assay | Inhibition of human SNU-423 cell growth in a cell viability assay. IC50=70.6017 μM | ||||
| SW1088 | Growth inhibition assay | Inhibition of human SW1088 cell growth in a cell viability assay. IC50=50.0201 μM | ||||
| SW1783 | Growth inhibition assay | Inhibition of human SW1783 cell growth in a cell viability assay. IC50=52.4982 μM | ||||
| SBC-5 | Growth inhibition assay | Inhibition of human SBC-5 cell growth in a cell viability assay. IC50=51.1085 μM | ||||
| A375 | Growth inhibition assay | Inhibition of human A375 cell growth in a cell viability assay. IC50=53.6768 μM | ||||
| AM-38 | Growth inhibition assay | Inhibition of human AM-38 cell growth in a cell viability assay. IC50=52.9492 μM | ||||
| YH-13 | Growth inhibition assay | Inhibition of human YH-13 cell growth in a cell viability assay. IC50=60.0468 μM | ||||
| TYK-nu | Growth inhibition assay | Inhibition of human TYK-nu cell growth in a cell viability assay. IC50=76.6063 μM | ||||
| COLO-668 | Growth inhibition assay | Inhibition of human COLO-668 cell growth in a cell viability assay. IC50=60.5077 μM | ||||
| ES6 | Growth inhibition assay | Inhibition of human ES6 cell growth in a cell viability assay. IC50=57.7541 μM | ||||
| D-247MG | Growth inhibition assay | Inhibition of human D-247MG cell growth in a cell viability assay. IC50=59.5888 μM | ||||
| H4 | Growth inhibition assay | Inhibition of human H4 cell growth in a cell viability assay. IC50=60.5614 μM | ||||
| HMV-II | Growth inhibition assay | Inhibition of human HMV-II cell growth in a cell viability assay. IC50=157.194 μM | ||||
| HT-1080 | Growth inhibition assay | Inhibition of human HT-1080 cell growth in a cell viability assay. IC50=62.203 μM | ||||
| IA-LM | Growth inhibition assay | Inhibition of human IA-LM cell growth in a cell viability assay. IC50=54.091 μM | ||||
| K-562 | Growth inhibition assay | Inhibition of human K-562 cell growth in a cell viability assay. IC50=50.5633 μM | ||||
| MEL-JUSO | Growth inhibition assay | Inhibition of human MEL-JUSO cell growth in a cell viability assay. IC50=56.1737 μM | ||||
| M059J | Growth inhibition assay | Inhibition of human M059J cell growth in a cell viability assay. IC50=51.0252 μM | ||||
| NB6 | Growth inhibition assay | Inhibition of human NB6 cell growth in a cell viability assay. IC50=71.0797 μM | ||||
| NCI-H1975 | Proliferation assay | 72 h | Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M mutant after 72 hrs by SRB assay, IC50=0.148 μM | |||
| A431 | Proliferation assay | 72 h | Antiproliferative activity against human A431 cells after 72 hrs by SRB assay, IC50=0.023 nM | |||
| MDA-MB-231 | Proliferation assay | 72 h | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay, EC50=1 nM | |||
| NCI-H1975 | Cytotoxicity assay | 48 h | Cytotoxicity against human NCI-H1975 cells after 48 hrs by MTT assay, IC50=0.392 μM | |||
| NIH/3T3 | Cytotoxicity assay | 48 h | Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay, IC50=3.605 μM | |||
| A549 | Cytotoxicity assay | 72 h | Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=0.05 μM | |||
| PC3 | Cytotoxicity assay | 72 h | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay, IC50=4.1 μM | |||
| HeLa | Cytotoxicity assay | 72 h | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay, IC50=6.81 μM | |||
| MCF7 | Cytotoxicity assay | 72 h | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay, IC50=5.83 μM | |||
| NSCLC | Cytotoxicity assay | 72 h | Cytotoxicity against human NSCLC cells, IC50=0.5 nM | |||
| Click to View More Cell Line Experimental Data | ||||||
Solubility
|
In vitro |
DMSO
: 100 mg/mL
(139.43 mM)
Water : Insoluble Ethanol : Insoluble |
Molarity Calculator
Dilution Calculator
Molecular Weight Calculator
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In vivo |
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
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Chemical Information, Storage & Stability
| Molecular Weight | 717.18 | Formula | C24H25ClFN5O3.2C4H4O4 |
Storage (From the date of receipt) | |
|---|---|---|---|---|---|
| CAS No. | 850140-73-7 | Download SDF | Storage of Stock Solutions |
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|
| Synonyms | BIBW2992 Dimaleate | Smiles | CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O | ||
Mechanism of Action
| Targets/IC50/Ki |
EGFR (L858R)
(Cell-free assay) 0.4 nM
EGFR (wt)
(Cell-free assay) 0.5 nM
EGFR (L858R/T790M)
(Cell-free assay) 10 nM
HER2
(Cell-free assay) 14 nM
|
|---|---|
| In vitro |
BIBW2992 is more effective than erlotinib, gefitinib, or lapatinib in inhibiting survival of lung cancer cell lines harboring wild-type (H1666) or L858R/T790M (NCI-H1975) EGFR. BIBW2992 is similarly effective against NSCLC lines expressing HER2 776insV (NCI-H1781) or EGFR E746_A750del (HCC827), but shows no activity toward A549 cells, which express wild-type EGFR and HER2. Afatinib enhances cytotoxicity of topotecan and mitoxantrone to SP cells, and increases the apoptosis induced by topotecan and mitoxantrone in SP cells.
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| Kinase Assay |
In vitro kinase activity assay
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EGFR kinase: Each 100 µL enzyme reaction contained 10 μL of inhibitor in 50% Me2SO, 20 μL of substrate solution (200 mM HEPES pH 7.4, 50 mM Mg-acetate, 2.5 mg/mL poly (EY), 5 μg/mL bio-pEY) and 20 µL enzyme preparation. The enzymatic reaction is started by addition of 50 µL of a 100 µM ATP solution made in 10 mM MgCl2. Assays are carried out at room temperature for 30 min and terminated by the addition of 50 µL of stop solution (250 mM EDTA in 20 mM HEPES pH 7.4). 100 µL are transferred to a streptavidin coated microtiterplate, after an incubation time of 60 min at room temperature the plate is washed with 200 µL of wash solution (50 mM Tris, 0.05% Tween20). A 100 µL aliquot of a HRPO- labeled anti-PY antibody (PY20H Anti-Ptyr:HRP ) 250 ng/mL are added to the wells. After 60 min of incubation, the plate is washed three times with a 200 µL wash solution. The samples are then developed with a 100µL TMB Peroxidase Solution (A:B= 1:1). The reaction is stopped after 10 min. The plate is transferred to an ELISA reader and extinction is measured at OD450nm. HER2-IC enzyme: Enzyme activity is assayed in the presence or absence of serial inhibitor dilutions performed in 50 % Me2SO. Each 100 µL reaction contains similar components as described for EGFR kinase assay with addition of 1000 µM Na3VO4. The enzymatic reaction is started by addition of 50µL of 500 µM ATP solution made in 10 mM Mg-acetate. The dilution of the enzyme is set so that incorporation of phosphate into bio-pEY is linear with respect to time and amount of enzyme. The enzyme preparation is diluted in 20 mM HEPES pH 7.4, 130 mM NaCl, 0.05% Triton X-100, 1 mM DTT and 10% glycerol. Assays are carried out at room temperature for 30 min and terminated by the addition of 50 µL of stop solution. Src kinase assays: Each 100 µL reaction contained 10 µL of inhibitor in 50 % Me2SO, 20µL of enzyme preparation, 20 µL of substrate solution supplemented with 1000 µM Na3VO4. The enzymatic reaction is started by addition of 50 µL of a 1000 µM ATP solution made in 10 mM Mg-acetate. BIRK kinase assay: 250 mM Tris pH 7.4, 10mM DTT, 2.5 mg/mL poly(EY), 5 mg/mL bio-pEY is used as substrate solution and enzymatic reaction is started by addition of 50 µL of a 2 mM ATP solution made in 8 mM MnCl2, 20 mM Mg-acetate. VEGF2 and HGFR kinase assays: Assays are carried out at room temperature for 20 minutes and terminated by the addition of 10 µL of 5 % H3PO4. The precipitate is then trapped onto GF/B filters using a 96 well filter mate universal harvester. After extensive washing the filter plate is dried for 1 h at 50°C, sealed and incorporated radioactivity is determined by scintillation counting using a TopCount™ or a Microbeta b counter™.
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| In vivo |
In the MDA-MB-453 xenograft model, BIBW2992 (20 mg/kg, p.o.) results in dramatic tumor regression with a cumulative treated/control tumor volume ratio (T/C ratio) of 2%, and downregulation of EGFR and AKT phosphorylation. In A7, A431, FaDu, UT-SCC-14 and UT-SCC-15 xenograft models, application of BIBW 2992 (30 mg/kg, p.o.) leads to a significant prolongation of tumour growth time. In HER2-amplified xenograft medel, Afatinib (30 mg/kg, p.o.) results a markedly inhibition in tumor growth and a significant improvement in the duration of overall survival. In HER2-positive gastric cancer NCI-N87 xenograft, afatinib (25 mg/kg, p.o.) leads to dramatic tumor volume regression within 4 d and near-complete tumor resolution after 21 d of treatment.
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References |
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Applications
| Methods | Biomarkers | Images | PMID |
|---|---|---|---|
| Growth inhibition assay | Cell apoptosis Cell viability |
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25537503 |
| Western blot | CIP2A / p-AKT / AKT / PARP p-EGFR / p-IGF1R / p-ERK / p-AKT |
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25537503 |
| Immunofluorescence | p65 vacuoles |
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26317651 |
Clinical Trial Information
(data from https://clinicaltrials.gov, updated on 2024-05-22)
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06302621 | Recruiting | Advanced Solid Tumor|Unresectable Solid Tumor|Metastatic Solid Tumor|Cholangiocarcinoma |
Massachusetts General Hospital|Boehringer Ingelheim|Incyte Corporation |
July 1 2024 | Phase 1 |
| NCT05298176 | Recruiting | Non-Small Cell Lung Cancer |
Amsterdam UMC location VUmc |
January 4 2022 | Phase 2 |
| NCT04795245 | Completed | Non-squamous Non-Small Cell Lung Cancer |
Boehringer Ingelheim |
August 26 2021 | -- |
| NCT04497584 | Recruiting | Advanced Squamous Non Small Cell Lung Cancer |
University of Texas Southwestern Medical Center |
August 4 2021 | Phase 2 |
| NCT04413201 | Active not recruiting | Non-squamous NSCLC |
Michael Hopp|Boehringer Ingelheim|Johannes Gutenberg University Mainz |
September 11 2020 | Phase 4 |
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