For research use only.
Catalog No.S1905 Synonyms: UK-48340
CAS No. 88150-42-9
Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
Purity & Quality Control
Choose Selective Calcium Channel Inhibitors
|Description||Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.|
Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta.  Amlodipine is attributed to distinct membrane physico-chemical interactions. Amlodipine contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation.  Amlodipine increases plaque smooth muscle cell content (P<0.05), whereas atenolol decreases plaque inflammation.  Amlodipine attenuates intracellular neuronal Ca2+ increases elicited by KCl depolarization but does not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation. 
|In vivo||Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats.  Amlodipine significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury. |
-  Zhang X, et al. Circulation, 1998, 97(6), 576-580.
-  Mason RP, et al. J Mol Cell Cardiol, 1999, 31(1), 275-281.
-  Nussberger J, et al. Hypertension, 2008, 51(5), 1306-1311.
|In vitro||DMSO||82 mg/mL (200.54 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03722381||Withdrawn||Drug: Amlodipine Besylate||Hemodialysis|Pharmacokinetics||University of Michigan||January 2020||--|
|NCT04322266||Completed||Drug: HCP1701|Drug: HCP1306|Drug: HGP0904|Drug: HGP0608||Healthy||Hanmi Pharmaceutical Company Limited||December 21 2018||Phase 1|
|NCT03722524||Recruiting||Drug: amlodipine / indapamide / perindopril arginine FDC||Arterial Hypertension||Servier Russia||November 30 2018||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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