Catalog No.S1905 Synonyms: UK-48340
Molecular Weight(MW): 408.88
Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
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Choose Selective Calcium Channel Inhibitors
|Description||Amlodipine is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.|
Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta.  Amlodipine is attributed to distinct membrane physico-chemical interactions. Amlodipine contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation.  Amlodipine increases plaque smooth muscle cell content (P<0.05), whereas atenolol decreases plaque inflammation.  Amlodipine attenuates intracellular neuronal Ca2+ increases elicited by KCl depolarization but does not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation. 
|In vivo||Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats.  Amlodipine significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury. |
-  Zhang X, et al. Circulation, 1998, 97(6), 576-580.
-  Mason RP, et al. J Mol Cell Cardiol, 1999, 31(1), 275-281.
-  Nussberger J, et al. Hypertension, 2008, 51(5), 1306-1311.
|In vitro||DMSO||82 mg/mL (200.54 mM)|
|Ethanol||82 mg/mL (200.54 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03722381||Not yet recruiting||Drug: Amlodipine Besylate||Hemodialysis|Pharmacokinetics||University of Michigan||December 2019||--|
|NCT03722524||Recruiting||Drug: amlodipine / indapamide / perindopril arginine FDC||Arterial Hypertension||Servier Russia||November 30 2018||--|
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