For research use only.

Catalog No.S1905 Synonyms: UK-48340

6 publications

Amlodipine  Chemical Structure

CAS No. 88150-42-9

Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.

Size Price Stock Quantity  
10mM (1mL in DMSO) GBP 106 In stock
GBP 79 In stock
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Selleck's Amlodipine has been cited by 6 publications

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Biological Activity

Description Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
Calcium channel [1]
In vitro

Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta. [1] Amlodipine is attributed to distinct membrane physico-chemical interactions. Amlodipine contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation. [2] Amlodipine increases plaque smooth muscle cell content (P<0.05), whereas atenolol decreases plaque inflammation. [3] Amlodipine attenuates intracellular neuronal Ca2+ increases elicited by KCl depolarization but does not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation. [4]

In vivo Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats. [5] Amlodipine significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury. [6]


Solubility (25°C)

In vitro DMSO 82 mg/mL (200.54 mM)
Ethanol 82 mg/mL (200.54 mM)
Water Insoluble

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Chemical Information

Molecular Weight 408.88


CAS No. 88150-42-9
Storage powder
in solvent
Synonyms UK-48340

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03371797 Completed Drug: Valsartan Amlodipine - Essential Hypertension PharmEvo Pvt Ltd February 20 2018 --
NCT02707913 Completed Drug: BF-Amlodipine Tablet 10mg|Drug: Norvasc Tablet 10mg Healthy Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited|Chinese University of Hong Kong March 2016 Phase 1
NCT02353806 Completed Drug: Amlodipine besylate Chronic Hypertension in Pregnancy University of Texas Southwestern Medical Center|National Center for Advancing Translational Science (NCATS) January 2015 Phase 4
NCT02064556 Completed Drug: Amlodipine 10mg|Drug: Amlodipine 10mg/Candesartan 32mg Hypertension Chong Kun Dang Pharmaceutical May 2014 Phase 1
NCT02065492 Completed Drug: Standard Chelation|Drug: Amlodipine Thalassemia Aga Khan University February 2014 Phase 2|Phase 3
NCT01835418 Unknown status Drug: Amlodipine Hypertension Allina Health System April 2013 Not Applicable

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