For research use only.
Catalog No.S1905 Synonyms: UK-48340
CAS No. 88150-42-9
Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
Selleck's Amlodipine has been cited by 6 publications
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Choose Selective Calcium Channel Inhibitors
|Description||Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.|
Amlodipine causes a dose-dependent increase in nitrite production. Amlodipine also increases nitrite production in large coronary arteries and in aorta.  Amlodipine is attributed to distinct membrane physico-chemical interactions. Amlodipine contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation.  Amlodipine increases plaque smooth muscle cell content (P<0.05), whereas atenolol decreases plaque inflammation.  Amlodipine attenuates intracellular neuronal Ca2+ increases elicited by KCl depolarization but does not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. Amlodipine also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation. 
|In vivo||Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats.  Amlodipine significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury. |
-  Zhang X, et al. Circulation, 1998, 97(6), 576-580.
-  Mason RP, et al. J Mol Cell Cardiol, 1999, 31(1), 275-281.
-  Nussberger J, et al. Hypertension, 2008, 51(5), 1306-1311.
|In vitro||DMSO||82 mg/mL (200.54 mM)|
|Ethanol||82 mg/mL (200.54 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03371797||Completed||Drug: Valsartan Amlodipine -||Essential Hypertension||PharmEvo Pvt Ltd||February 20 2018||--|
|NCT02707913||Completed||Drug: BF-Amlodipine Tablet 10mg|Drug: Norvasc Tablet 10mg||Healthy||Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited|Chinese University of Hong Kong||March 2016||Phase 1|
|NCT02353806||Completed||Drug: Amlodipine besylate||Chronic Hypertension in Pregnancy||University of Texas Southwestern Medical Center|National Center for Advancing Translational Science (NCATS)||January 2015||Phase 4|
|NCT02064556||Completed||Drug: Amlodipine 10mg|Drug: Amlodipine 10mg/Candesartan 32mg||Hypertension||Chong Kun Dang Pharmaceutical||May 2014||Phase 1|
|NCT02065492||Completed||Drug: Standard Chelation|Drug: Amlodipine||Thalassemia||Aga Khan University||February 2014||Phase 2|Phase 3|
|NCT01835418||Unknown status||Drug: Amlodipine||Hypertension||Allina Health System||April 2013||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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