Aspirin

Catalog No.S3017 Synonyms: Acetylsalicylic acid

Aspirin Chemical Structure

Molecular Weight(MW): 180.16

Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Purity & Quality Control

Choose Selective COX Inhibitors

Biological Activity

Description Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
Targets
COX2 [1] COX1 [1]
In vitro

Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response. [2] Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices. [3] Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and 5-lipoxygenase interactions. [4] Aspirin treatment inhibits the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha in 3T3-L1 and Hep G2 cells treated with tumor necrosis factor (TNF)-alpha. Aspirin treatment inhibits phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha. Aspirin rescues insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human AGS cells MoLFSpVv[3Srb36gZZN{[Xl? MoHYNVUuPjBizsztc4wwVA>? NEPIUnoyOiCq M{DpdmlvcGmkaYTpc44hd2ZiRYPjbIVzcWOqaXGgZ49tcS2|dHnteYxifGWmIFnMMVgheHKxZIXjeIlwdiCrbjDoeY1idiCDR2OgZ4VtdHNiYYSgNVUhfG9iNkCgeY1wdC:OIHHmeIVzKDF{IHjyd{BjgSCHTFnTRS=> MnG0NlAyPTNzOEO=
human PC3 cells M370OWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2\K[lMxOCEQvF2= NEHV[mg1QCCq M{fJdWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHBEOyClZXzsd{BifCB|MECgeW0h[W[2ZYKgOFghcHK|IHL5JIFt[W2jcjDicJVmKGG|c3H5 MnzuNlI1QTR4MUe=
human HCT116 cells M2jxV2Z2dmO2aX;uJIF{e2G7 NH;TTVkyKG2P MoLYOkBp NF7jVJdKdmirYnn0bY9vKG:oIGTOSk1idHCqYT3pcoR2[2WmIF7GMYtieHCjQjDhZ5RqfmG2aX;uJIlvKGi3bXHuJGhEXDFzNjDj[YxteyCjdDCxJI1OKGGodHXyJFYhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigQ>? MoDINlIyPTR6M{S=
human THP1 cells NVvVTW1zTnWwY4Tpc44h[XO|YYm= MW[xNFAh|ryP MUizNEBucW6| NXvVbnUyUXK{ZY\ldpNq[mynIHnubIljcXSrb36gc4YhS0:[LUGgbY4hcHWvYX6gWGhROSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIFz[WOqaXTvcolkKGGlaXStbY5lfWOnZDDUXGIzKG[xcn3heIlwdiCjdDCxNFAhfU1iaX7jeYJifGWmIH\vdkA{OCCvaX7zJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHejc3jveZQhdWWjc4Xy[YQhOzBibXnud{Bxd3O2IHHyZYNpcWSxbnnjJIFkcWRiY3jhcIxmdmenIHL5JJJi\GmxaX3teY5w[XO|YYm= NEezOZAzOzZ3MUO1PS=>
human PANC1 cells M13qUWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1fJbVMxOCEQvF2= MX20PEBp M3W3fGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHBCVkNzIHPlcIx{KGG2IEOwNEB2VSCjZoTldkA1QCCqcoOgZpkh[WyjbXHyJIJtfWViYYPzZZk> NIr2dG0zOjR7NE[xOy=>
human SKBR3 cells MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmfYN|AxKM7:TR?= NEPwO241QCCq NVLPT2x1T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW0uEUkOgZ4VtdHNiYYSgN|AxKHWPIHHmeIVzKDR6IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigQ>? M4CxRlIzPDl2NkG3
human MDA-MB-231 cells NWPkbpoxTnWwY4Tpc44h[XO|YYm= MkmzNVAxKM7:TR?= M2P2dlMxKG2rboO= M2rS[2lzemW4ZYLzbYJt\SCrbnjpZol1cW:wIH;mJGNQYC1zIHnuJIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjcnHjbIlld26rYzDhZ4llNWmwZIXj[YQhWEeHMjDmc5Ju[XSrb36gZZQhOTByIIXNJIlv[3WkYYTl[EBnd3JiM{CgcYlveyCob3zsc5dm\CCkeTDjc41xd3WwZDD3ZZNpd3W2IH3lZZN2emWmIEOwJI1qdnNicH;zeEBiemGlaHnkc45q[yCjY3nkJINp[WyuZX7n[UBjgSC{YXTpc4ludXWwb3Hzd4F6 NGnGbmMzOzZ3MUO1PS=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 36 mg/mL (199.82 mM)
Ethanol 36 mg/mL (199.82 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+PBS
For best results, use promptly after mixing.
10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 180.16
Formula

C9H8O4

CAS No. 50-78-2
Storage powder
in solvent
Synonyms Acetylsalicylic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03590821 Not yet recruiting Healthy University of Pennsylvania November 2019 Early Phase 1
NCT03590821 Not yet recruiting Healthy University of Pennsylvania November 2019 Early Phase 1
NCT03871517 Not yet recruiting Ischemic Stroke|Indobufen|Aspirin Ministry of Science and Technology of the People´s Republic of China May 1 2019 Phase 4
NCT03871517 Not yet recruiting Ischemic Stroke|Indobufen|Aspirin Ministry of Science and Technology of the People´s Republic of China May 1 2019 Phase 4
NCT03820466 Not yet recruiting Acute Chest Syndrome Universitätsklinikum Hamburg-Eppendorf May 2019 Phase 3
NCT03820466 Not yet recruiting Acute Chest Syndrome Universitätsklinikum Hamburg-Eppendorf May 2019 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID