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Aspirin (NSC 27223)
Catalog No.S3017 Synonyms: Acetylsalicylic acid, ASA
For research use only.
Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.
CAS No. 50-78-2
Selleck's Aspirin (NSC 27223) has been cited by 20 publications
Purity & Quality Control
Choose Selective COX Inhibitors
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Other COX Products
Biological Activity
| Description | Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| In vitro |
Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response. [2] Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices. [3] Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and 5-lipoxygenase interactions. [4] Aspirin treatment inhibits the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha in 3T3-L1 and Hep G2 cells treated with tumor necrosis factor (TNF)-alpha. Aspirin treatment inhibits phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha. Aspirin rescues insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha. [5] |
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| Assay |
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Protocol (from reference)
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Solubility (25°C)
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In vivo |
Add solvents to the product individually and in order |
10mg/mL |
Chemical Information
| Molecular Weight | 180.16 | ||
|---|---|---|---|
| Formula | C9H8O4 |
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| CAS No. | 50-78-2 | ||
| Storage | 3 years | -20°C | powder |
| 2 years | -80°C | in solvent | |
| Smiles | CC(=O)OC1=CC=CC=C1C(=O)O | ||
In vivo Formulation Calculator (Clear solution)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Clinical Trial Information
| NCT Number | Recruitment | Interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT04563546 | Not yet recruiting | Other: Quality Improvement | Acute Coronary Syndrome | Duke University | January 1 2023 | Not Applicable |
| NCT05411718 | Not yet recruiting | Drug: Naproxen|Drug: Aspirin | T Cells|Colorectal Cancer|Lynch Syndrome | M.D. Anderson Cancer Center|National Institutes of Health (NIH)|National Cancer Institute (NCI) | November 25 2022 | Phase 2 |
| NCT05198960 | Recruiting | Drug: Direct Oral Anticoagulants|Drug: Low-dose aspirin | Polycythemia Vera|Essential Thrombocythemia|Prefibrotic/Early Primary Myelofibrosis|JAK2 V617F|High-risk Patients | University Hospital Brest | July 2022 | Phase 3 |
| NCT05257824 | Recruiting | Drug: Aspirin 100mg|Drug: Clopidogrel 75mg | Aneurysm Cerebral|Endovascular Procedures | Seoul National University Bundang Hospital|Soonchunhyang University Hospital|Soonchunhyang University Cheonan Hospital|Seoul National University Hospital|Pusan National University Yangsan Hospital|Keimyung University Dongsan Medical Center|Seoul St. Mary''s Hospital|Uijeongbu St. Mary''s Hospital|Ajou University School of Medicine|Chungnam National University Sejong Hospital|Severance Hospital|Asan Medical Center|Yonsei University Gangnam Severance Hospital | June 23 2022 | Phase 4 |
(data from https://clinicaltrials.gov, updated on 2022-08-01)
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