Catalog No.S3017 Synonyms: Acetylsalicylic acid

Aspirin Chemical Structure

Molecular Weight(MW): 180.16

Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Purity & Quality Control

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Biological Activity

Description Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
COX2 [1] COX1 [1]
In vitro

Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response. [2] Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices. [3] Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and 5-lipoxygenase interactions. [4] Aspirin treatment inhibits the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha in 3T3-L1 and Hep G2 cells treated with tumor necrosis factor (TNF)-alpha. Aspirin treatment inhibits phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha. Aspirin rescues insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human AGS cells MXrGeY5kfGmxbjDhd5NigQ>? MYKxOU03OCEQvH3vcE9N M3;vclEzKGh? M1:2WWlvcGmkaYTpc44hd2ZiRYPjbIVzcWOqaXGgZ49tcS2|dHnteYxifGWmIFnMMVgheHKxZIXjeIlwdiCrbjDoeY1idiCDR2OgZ4VtdHNiYYSgNVUhfG9iNkCgeY1wdC:OIHHmeIVzKDF{IHjyd{BjgSCHTFnTRS=> MljaNlAyPTNzOEO=
human PC3 cells M3r3XGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mk\HN|AxKM7:TR?= NGXSUHU1QCCq MmTUS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGM{KGOnbHzzJIF1KDNyMDD1UUBi\nSncjC0PEBpenNiYomgZYxidWG{IHLseYUh[XO|YYm= Mmj6NlI1QTR4MUe=
human HCT116 cells MojHSpVv[3Srb36gZZN{[Xl? M1HhZlEhdU1? NUCwe5FYPiCq MlXiTY5pcWKrdHnvckBw\iCWTl[tZYxxcGFvaX7keYNm\CCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBpfW2jbjDIR3QyOTZiY3XscJMh[XRiMTDtUUBi\nSncjC2JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> M3n6SVIzOTV2OEO0
human THP1 cells NV;IZnVFTnWwY4Tpc44h[XO|YYm= NIXlWGgyODBizszN M4LmR|MxKG2rboO= NFG3[3RKenKndnXyd4ljdGViaX7obYJqfGmxbjDv[kBEV1hvMTDpckBpfW2jbjDUTHAyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gZZJi[2irZH;ubYMh[WOrZD3pcoR2[2WmIGTYRlIh\m:{bXH0bY9vKGG2IEGwNEB2VSCrbnP1ZoF1\WRiZn;yJFMxKG2rboOg[o9tdG:5ZXSgZpkh[2:vcH;1coQhf2G|aH;1eEBu\WG|dYLl[EA{OCCvaX7zJJBwe3RiYYLhZ4hq\G:waXOgZYNq\CClaHHscIVv\2ViYomgdoFlcW:rbX31co9ie3OjeR?= NW\xc4xkOjN4NUGzOVk>
human PANC1 cells NXzqW5Z3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWrPZo9FOzByIN88US=> NIjaXlg1QCCq MojkS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGFPSzFiY3XscJMh[XRiM{CwJJVOKGGodHXyJFQ5KGi{czDifUBidGGvYYKgZox2\SCjc4PhfS=> NF\1[mszOjR7NE[xOy=>
human SKBR3 cells M2XEWWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYGzNFAh|ryP NX\lNYpFPDhiaB?= NVTJTmtnT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW0uEUkOgZ4VtdHNiYYSgN|AxKHWPIHHmeIVzKDR6IHjyd{BjgSCjbHHtZZIh[my3ZTDhd5NigQ>? NILVUJIzOjR7NE[xOy=>
human MDA-MB-231 cells Mlv3SpVv[3Srb36gZZN{[Xl? NEDHSVkyODBizszN MUOzNEBucW6| NVvLNG9nUXK{ZY\ldpNq[mynIHnubIljcXSrb36gc4YhS0:[LUGgbY4hcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIHHyZYNpcWSxbnnjJIFkcWRvaX7keYNm\CCSR1WyJIZwem2jdHnvckBifCBzMECgeW0hcW6ldXLheIVlKG[xcjCzNEBucW6|IH\vcIxwf2WmIHL5JINwdXCxdX7kJJdie2ixdYSgcYVie3W{ZXSgN|AhdWmwczDwc5N1KGG{YXPobYRwdmmlIHHjbYQh[2ijbHzlcodmKGK7IILh[IlwcW2vdX7vZZN{[Xl? NFm5ZZczOzZ3MUO1PS=>

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 36 mg/mL (199.82 mM)
Ethanol 36 mg/mL (199.82 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 180.16


CAS No. 50-78-2
Storage powder
in solvent
Synonyms Acetylsalicylic acid

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04070573 Not yet recruiting Drug: acetylsalicylic acid Preeclampsia Weill Medical College of Cornell University October 2019 Phase 3
NCT04097912 Not yet recruiting Drug: Acetylsalicylic Acid (Aspirin BAYE4465) Myocardial Infarction|Stroke (Including Ischaemic Stroke and Transient Ischaemic Attack)|Unstable Angina|Angina|Ischaemic Heart Disease Bayer September 30 2019 --
NCT03188705 Not yet recruiting Drug: Clopidogrel|Drug: Aspirin Heart Diseases|Coronary Disease|Coronary Artery Disease|Cardiovascular Diseases|Myocardial Ischemia|Artery Occlusion|Aspirin Sensitivity|Clopidogrel Poor Metabolism of|Platelet Dysfunction|Platelet Thrombus University of Maryland Baltimore September 1 2019 Phase 4
NCT04040465 Not yet recruiting Drug: Aspirin Aspirin Sensitivity University of Utah|University of Colorado Denver August 1 2019 Early Phase 1
NCT04081831 Active not recruiting Drug: Acetylsalicylic Acid (Aspirin BAYE4465) Gastrointestinal Cancer Bayer July 31 2019 --

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID