Catalog No.S3017 Synonyms: Acetylsalicylic acid
Molecular Weight(MW): 180.16
Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
Purity & Quality Control
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|Description||Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.|
Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.  Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response.  Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices.  Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and 5-lipoxygenase interactions.  Aspirin treatment inhibits the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha in 3T3-L1 and Hep G2 cells treated with tumor necrosis factor (TNF)-alpha. Aspirin treatment inhibits phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha. Aspirin rescues insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha. 
-  Kopp E, et al. Science, 1994, 265(5174), 956-959.
-  Yin MJ, et al. Nature, 1998, 396(6706), 77-80.
-  Grilli M, et al. Science, 1996, 274(5291), 1383-1385.
|In vitro||DMSO||36 mg/mL (199.82 mM)|
|Ethanol||36 mg/mL (199.82 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04070573||Not yet recruiting||Drug: acetylsalicylic acid||Preeclampsia||Weill Medical College of Cornell University||October 2019||Phase 3|
|NCT04097912||Not yet recruiting||Drug: Acetylsalicylic Acid (Aspirin BAYE4465)||Myocardial Infarction|Stroke (Including Ischaemic Stroke and Transient Ischaemic Attack)|Unstable Angina|Angina|Ischaemic Heart Disease||Bayer||September 30 2019||--|
|NCT03188705||Not yet recruiting||Drug: Clopidogrel|Drug: Aspirin||Heart Diseases|Coronary Disease|Coronary Artery Disease|Cardiovascular Diseases|Myocardial Ischemia|Artery Occlusion|Aspirin Sensitivity|Clopidogrel Poor Metabolism of|Platelet Dysfunction|Platelet Thrombus||University of Maryland Baltimore||September 1 2019||Phase 4|
|NCT04040465||Not yet recruiting||Drug: Aspirin||Aspirin Sensitivity||University of Utah|University of Colorado Denver||August 1 2019||Early Phase 1|
|NCT04081831||Active not recruiting||Drug: Acetylsalicylic Acid (Aspirin BAYE4465)||Gastrointestinal Cancer||Bayer||July 31 2019||--|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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