Aspirin
Catalog No.S3017 Synonyms: Acetylsalicylic acid
Molecular Weight(MW): 180.16
Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
Cited by 2 publications
Purity & Quality Control
Choose Selective COX Inhibitors
Biological Activity
| Description | Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Targets |
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| In vitro |
Aspirin inhibits the activation of NF-kappa B, thus prevents the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B is retained in the cytosol. Aspirin also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Aspirin and salicylate are mediated in part by their specific inhibition of IKK-beta, thereby preventing activation by NF-kappaB of genes involved in the pathogenesis of the inflammatory response. [2] Aspirin is protective against neurotoxicity elicited by the excitatory amino acid glutamate in rat primary neuronal cultures and hippocampal slices. [3] Aspirin triggers transcellular biosynthesis of a previously unrecognized class of eicosanoidsduring coincubations of human umbilical vein endothelial cells (HUVEC) and neutrophils [polymorphonuclear leukocytes (PMN)]. Aspirin evokes a unique class of eicosanoids formed by acetylated PGHS-2 and 5-lipoxygenase interactions. [4] Aspirin treatment inhibits the phosphorylation of IRS-1 at Ser307 as well as the phosphorylation of JNK, c-Jun, and degradation of IkappaBalpha in 3T3-L1 and Hep G2 cells treated with tumor necrosis factor (TNF)-alpha. Aspirin treatment inhibits phosphorylation of Akt and the mammalian target of rapamycin (but not extracellular regulated kinase or PKCzeta) in response to TNF-alpha. Aspirin rescues insulin-induced glucose uptake in 3T3-L1 adipocytes pretreated with TNF-alpha. [5] |
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| Cell Data |
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Protocol
Solubility (25°C)
| In vitro | DMSO | 36 mg/mL (199.82 mM) |
|---|---|---|
| Ethanol | 36 mg/mL (199.82 mM) | |
| Water | Insoluble | |
| In vivo | Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 4% DMSO+PBS For best results, use promptly after mixing. |
10mg/mL |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 180.16 |
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| Formula | C9H8O4 |
| CAS No. | 50-78-2 |
| Storage | powder |
| in solvent | |
| Synonyms | Acetylsalicylic acid |
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Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03590821 | Not yet recruiting | Healthy | University of Pennsylvania | November 2019 | Early Phase 1 |
| NCT03590821 | Not yet recruiting | Healthy | University of Pennsylvania | November 2019 | Early Phase 1 |
| NCT03871517 | Not yet recruiting | Ischemic Stroke|Indobufen|Aspirin | Ministry of Science and Technology of the People´s Republic of China | May 1 2019 | Phase 4 |
| NCT03871517 | Not yet recruiting | Ischemic Stroke|Indobufen|Aspirin | Ministry of Science and Technology of the People´s Republic of China | May 1 2019 | Phase 4 |
| NCT03820466 | Not yet recruiting | Acute Chest Syndrome | Universitätsklinikum Hamburg-Eppendorf | May 2019 | Phase 3 |
| NCT03820466 | Not yet recruiting | Acute Chest Syndrome | Universitätsklinikum Hamburg-Eppendorf | May 2019 | Phase 3 |
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