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AB680 CD markers inhibitor

Cat.No.S8908

AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73.
AB680 CD markers inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 580.82

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Quality Control

Batch: S890801 DMSO]100 mg/mL]false]Ethanol]25 mg/mL]false]Water]7 mg/mL]false Purity: 97.25%
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  • NMR
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97.25

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (172.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 25 mg/mL

Water : 7 mg/mL

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 580.82 Formula

C20H24ClFN4O9P2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2105904-82-1 -- Storage of Stock Solutions

Synonyms N/A Smiles CC(C1=CC=CC=C1F)NC2=CC(=NC3=C2C=NN3C4C(C(C(O4)COP(=O)(CP(=O)(O)O)O)O)O)Cl

Mechanism of Action

Targets/IC50/Ki
CD73
4.9 pM(Ki)
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04575311 Completed
Healthy Volunteers
Arcus Biosciences Inc.
 October 20 2020 Phase 1
NCT03677973 Completed
Healthy Volunteers
Arcus Biosciences Inc.
 October 16 2018 Phase 1

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