Catalog No.S4817 Synonyms: Tenormin, Normiten, Blokium
Molecular Weight(MW): 266.34
Atenolol is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.
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|Description||Atenolol is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.|
|In vivo||In clinical pharmacokinetics studies, atenolol is a hydrophilic betareceptor blocking drug, which is predominantly eliminated via the kidneys, only about 5% of the atenolol is metabolised by the liver. After oral administration atenolol is incompletely absorbed from the intestine, so about 50% of the beta blocker are finally biovailable. In plasma only 3% of atenolol are protein-bound. After oral administration elimination half life of atenolol is calculated from 6 to 9 h. There exists a linear relationship between the atenolol plasma levels and the degree of beta blocking effect measured by inhibition of the exercise-induced tachycardia while no correlation is found between plasma levels of atenolol and blood pressure lowering activity of the drug.|
|In vitro||DMSO||53 mg/mL (198.99 mM)|
|Ethanol||53 mg/mL (198.99 mM)|
|Water||35 mg/mL (131.41 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Tenormin, Normiten, Blokium|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01719367||Completed||Drug: Atenolol||Atrial Fibrillation||Vanderbilt University Medical Center||January 2013||Not Applicable|
|NCT01361087||Withdrawn||Other: Blood draw||Marfan Syndrome||Ann & Robert H Lurie Children''s Hospital of Chicago|Johns Hopkins University||April 2011||Phase 3|
|NCT01522950||Completed||Drug: Nebivolol|Drug: atenolol|Drug: placebo||Hypertension||University of Minnesota - Clinical and Translational Science Institute|Forest Laboratories||May 2010||Phase 2|
|NCT01132768||Terminated||Drug: Atenolol|Drug: olmesartan medoxomil||Essential Hypertension|Carotid Plaque||Daiichi Sankyo Europe GmbH a Daiichi Sankyo Company|Daiichi Sankyo Inc.||May 2010||Phase 4|
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