For research use only.

Catalog No.S4817 Synonyms: Tenormin, Normiten, Blokium

1 publication

Atenolol Chemical Structure

CAS No. 29122-68-7

Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.

Selleck's Atenolol has been cited by 1 publication

Purity & Quality Control

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.
β1 receptor [1]
(Cell-free assay)
β2 receptor [1]
(Cell-free assay)
0.25 μM(Kd) 1 μM(Kd)
In vivo In clinical pharmacokinetics studies, atenolol is a hydrophilic betareceptor blocking drug, which is predominantly eliminated via the kidneys, only about 5% of the atenolol is metabolised by the liver. After oral administration atenolol is incompletely absorbed from the intestine, so about 50% of the beta blocker are finally biovailable. In plasma only 3% of atenolol are protein-bound. After oral administration elimination half life of atenolol is calculated from 6 to 9 h. There exists a linear relationship between the atenolol plasma levels and the degree of beta blocking effect measured by inhibition of the exercise-induced tachycardia while no correlation is found between plasma levels of atenolol and blood pressure lowering activity of the drug[3].


Animal Research:


- Collapse
  • Animal Models: spontaneously hypertensive rats (SHR), Wistar-Kyoto (WKY)
  • Dosages: 20 mg/kg
  • Administration: s.c.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 53 mg/mL (198.99 mM)
Water 35 mg/mL (131.41 mM)
Ethanol '53 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 266.34


CAS No. 29122-68-7
Storage powder
in solvent
Synonyms Tenormin, Normiten, Blokium
Smiles CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04224675 Not yet recruiting Drug: Atenolol Aneurysm Onassis Cardiac Surgery Centre March 7 2020 Not Applicable
NCT01719367 Completed Drug: Atenolol Atrial Fibrillation Vanderbilt University Medical Center January 2013 Not Applicable
NCT01361087 Withdrawn Other: Blood draw Marfan Syndrome Ann & Robert H Lurie Children''s Hospital of Chicago|Johns Hopkins University April 2011 Phase 3
NCT01132768 Terminated Drug: Atenolol|Drug: olmesartan medoxomil Essential Hypertension|Carotid Plaque Daiichi Sankyo Europe GmbH a Daiichi Sankyo Company|Daiichi Sankyo Inc. May 2010 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Adrenergic Receptor Signaling Pathway Map

Related Adrenergic Receptor Products

Tags: buy Atenolol | Atenolol ic50 | Atenolol price | Atenolol cost | Atenolol solubility dmso | Atenolol purchase | Atenolol manufacturer | Atenolol research buy | Atenolol order | Atenolol mouse | Atenolol chemical structure | Atenolol mw | Atenolol molecular weight | Atenolol datasheet | Atenolol supplier | Atenolol in vitro | Atenolol cell line | Atenolol concentration | Atenolol nmr
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID