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AST5902 trimesylate

AST5902 is the principal metabolite of alflutinib both in vitro and in vivo, which exerts remarkable antineoplastic activity similar to alflutinib. AST5902 exhibits much weak CYP3A4 induction potential compared to alflutinib.

AST5902 trimesylate Chemical Structure

AST5902 trimesylate Chemical Structure

CAS: 2412155-74-7

Purity & Quality Control

Batch: S598401 Water] 100 mg/mL] false] DMSO] 50 mg/mL] false] Ethanol] Insoluble] false Purity: 99.37%
99.37

AST5902 trimesylate Related Products

Biological Activity

Description AST5902 is the principal metabolite of alflutinib both in vitro and in vivo, which exerts remarkable antineoplastic activity similar to alflutinib. AST5902 exhibits much weak CYP3A4 induction potential compared to alflutinib.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05364073 Recruiting
Non-Small Cell Lung Cancer (NSCLC)|Metastatic Non-Small Cell Lung Cancer|Advanced Non-Small Cell Lung Cancer|HER2 Exon 20 Mutations|EGFR Exon 20 Mutations|EGFR Uncommon Mutations Including G719X and S768I
ArriVent BioPharma Inc.
 June 30 2022 Phase 1
NCT03941340 Completed
Healthy Male Volunteers
Allist Pharmaceuticals Inc.
 April 8 2019 Phase 1
NCT03926182 Completed
Healthy Male Volunteers
Allist Pharmaceuticals Inc.
 February 19 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 842.88 Formula

C30H41F3N8O11S3
CAS No. 2412155-74-7 SDF --
Smiles CNCCN(C)C1=NC(=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C1NC(=O)C=C)OCC(F)(F)F.C[S](O)(=O)=O.C[S](O)(=O)=O.C[S](O)(=O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL

DMSO : 50 mg/mL ( (59.32 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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