AZD8055

For research use only.

Catalog No.S1555

146 publications

AZD8055 Chemical Structure

Molecular Weight(MW): 465.54

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.

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Selleck's AZD8055 has been cited by 146 publications

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.
Features First drug to inhibit both types of mTOR protein.
Targets
mTOR (truncated) [1]
(MDA-MB-468 cells)
mTOR (full length) [1]
(MDA-MB-468 cells)
0.13 nM 0.8 nM
In vitro

AZD8055 shows low activity (∼1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells. [1] AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. [2] AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7 nM and induces significant differences in EFS distribution. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
LU-139 NVO1WYd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jQZWlEPTB;MD6wNlM{OSEQvF2= NEjLfmpUSU6JRWK=
NCI-H720 Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEP1VXVKSzVyPUCuNFI6OzhizszN M2jtNHNCVkeHUh?=
KARPAS-45 MmLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLjTWM2OD1yLkCzN|cyKM7:TR?= MY\TRW5ITVJ?
EW-3 M{K2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDLZWc5UUN3ME2wMlA1ODV4IN88US=> MnjOV2FPT0WU
SBC-1 NGTCbpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOyTWM2OD1yLkC0OVgyKM7:TR?= NUj4eVF3W0GQR1XS
NCI-H209 NIjnRW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEW0OVMh|ryP NHf5WlRUSU6JRWK=
EoL-1-cell NInMfJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLXTWM2OD1yLkC2OVY6KM7:TR?= NWTF[XV1W0GQR1XS
H9 NX;n[ndVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;qTWM2OD1yLkC2OlkzKM7:TR?= MVfTRW5ITVJ?
AN3-CA MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[3NmlEPTB;MD6wO|k2OSEQvF2= NHrrNodUSU6JRWK=
HH M2HiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljlTWM2OD1yLkC4NFA6KM7:TR?= MkHuV2FPT0WU
KU812 NH\TZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEiwOFMh|ryP NIf3ZoNUSU6JRWK=
DU-4475 MkGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzEeo1oUUN3ME2wMlA5ODR5IN88US=> M2jyPXNCVkeHUh?=
CTV-1 NH\tN|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H2fWlEPTB;MD6wPFY1OSEQvF2= M3LDPHNCVkeHUh?=
BV-173 NE\lfYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEmwOlEh|ryP NW\hfJZ2W0GQR1XS
ES5 NILJc29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\ZTWM2OD1yLkC5N|Uh|ryP M365[3NCVkeHUh?=
G-402 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTBwMEm5PEDPxE1? M4PsVHNCVkeHUh?=
MV-4-11 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTzOoNYUUN3ME2wMlExOzR5IN88US=> M1XqcXNCVkeHUh?=
NB69 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXMTWM2OD1yLkGzOUDPxE1? MnnIV2FPT0WU
EGI-1 M3T6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzQdm5KSzVyPUCuNVM2OzFizszN MlX6V2FPT0WU
EW-18 M4PiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny4TWM2OD1yLkG0NFc{KM7:TR?= MlfTV2FPT0WU
ME-180 Mlu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3O0XWlEPTB;MD6xOFY5OSEQvF2= NETDUlNUSU6JRWK=
D-283MED MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi3NW1tUUN3ME2wMlE1PzJ|IN88US=> M1ToRXNCVkeHUh?=
NB14 NUPTPYpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTMXXBKSzVyPUCuNVY1PDdizszN NFHUN21USU6JRWK=
Ramos-2G6-4C10 MkP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;CTWM2OD1yLkG2PVg{KM7:TR?= MXTTRW5ITVJ?
NBsusSR M1i5c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DDOWlEPTB;MD6xO|AyQSEQvF2= NHrTNplUSU6JRWK=
LAMA-84 NVnGZ3dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMUiwN|Ih|ryP NIL4R4VUSU6JRWK=
NCI-H1581 M3nQV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\UTWM2OD1yLkG4PVY3KM7:TR?= M2\6NXNCVkeHUh?=
A204 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7OSnB4UUN3ME2wMlE5QTdizszN M{LMRnNCVkeHUh?=
A549 NV7YUW03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLpV|FKSzVyPUCuNVk2PSEQvF2= M1K5OHNCVkeHUh?=
CAL-51 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHVNlZKSzVyPUCuNVk3PTFizszN MlK5V2FPT0WU
NKM-1 NWLjW3ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mon1TWM2OD1yLkKwNFI6KM7:TR?= MUPTRW5ITVJ?
LoVo MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\RTWM2OD1yLkKwNlAzKM7:TR?= MVnTRW5ITVJ?
HAL-01 NFm5clBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMkCyPVch|ryP NVXJbWhYW0GQR1XS
HCC2218 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC2Xm9{UUN3ME2wMlIxPjh6IN88US=> M2PjdHNCVkeHUh?=
BEN M1XnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ThRmlEPTB;MD6yNVI6OyEQvF2= MWPTRW5ITVJ?
LC-2-ad M4TT[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMkKwPFQh|ryP NH\sUGxUSU6JRWK=
LXF-289 NVvlVVZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf6cYlKSzVyPUCuNlUxPDFizszN NXu5fodRW0GQR1XS
HGC-27 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3GPYxZUUN3ME2wMlI3PDF2IN88US=> NEn6c3VUSU6JRWK=
LK-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnP1TWM2OD1yLkK2PFI1KM7:TR?= M1mzfHNCVkeHUh?=
CTB-1 MoDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\CfFNTUUN3ME2wMlI4OjF3IN88US=> M4TSd3NCVkeHUh?=
697 NYnOeZVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\3OFVKSzVyPUCuNlc{PjdizszN NW[y[HMyW0GQR1XS
ES7 MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT1TWM2OD1yLkK3N|g{KM7:TR?= NFPrfHRUSU6JRWK=
MG-63 Mor3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPIbo5TUUN3ME2wMlI4PDB5IN88US=> MWPTRW5ITVJ?
T47D NXrU[Fg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2CyfWlEPTB;MD6yO|Q4PSEQvF2= NWrSdXlLW0GQR1XS
RPMI-8226 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe5eoRKSzVyPUCuNlg2QDlizszN M3;GcHNCVkeHUh?=
NCI-H292 NHvhT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPmWm5KSzVyPUCuNlkyPjRizszN MmL0V2FPT0WU
HT NX3zU5VKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn3NIVKSzVyPUCuNlk{QCEQvF2= Ml\NV2FPT0WU
A3-KAW NE\1NGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMkm3OEDPxE1? M1i1XnNCVkeHUh?=
LB2241-RCC NUCyfYpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXDTWM2OD1yLkOwNVk5KM7:TR?= MX;TRW5ITVJ?
BB65-RCC M{DmbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLsTWM2OD1yLkOwPFA2KM7:TR?= NFnJTHZUSU6JRWK=
G-401 NETIPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3iZXpKSzVyPUCuN|A6QDZizszN NFizU29USU6JRWK=
TYK-nu M3\EWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzxcpgyUUN3ME2wMlMyQDZ2IN88US=> NFPkS4hUSU6JRWK=
NCI-SNU-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwM{KzN|Eh|ryP NXvkU|UxW0GQR1XS
CHL-1 NXvNb2RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnwd5BTUUN3ME2wMlMzPzB|IN88US=> Ml23V2FPT0WU
P30-OHK MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{ToN2lEPTB;MD6zNlcxPSEQvF2= MX\TRW5ITVJ?
PA-1 Mof3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTBTWM2OD1yLkOzOlE6KM7:TR?= MVvTRW5ITVJ?
LB1047-RCC M3PqXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f6TmlEPTB;MD6zOFA1PyEQvF2= MWPTRW5ITVJ?
EM-2 MkXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfUTWM2OD1yLkO0NVg5KM7:TR?= NF;VS5FUSU6JRWK=
VA-ES-BJ NIOxcGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnGyTWM2OD1yLkO0NlY5KM7:TR?= NWLOW29LW0GQR1XS
NCI-H520 NFTlZ4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\nUZRKSzVyPUCuN|Q5OzRizszN M1Xzd3NCVkeHUh?=
ECC10 NWLiVXJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrKTWM2OD1yLkO1NFM2KM7:TR?= NIj1dZBUSU6JRWK=
LNCaP-Clone-FGC MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF6yR|VKSzVyPUCuN|U{OTRizszN M3PDW3NCVkeHUh?=
ES8 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TxTmlEPTB;MD6zOlU2OyEQvF2= M3G3TXNCVkeHUh?=
HuO-3N1 MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX6SJZKSzVyPUCuN|g{PzlizszN MXzTRW5ITVJ?
L-363 NHjxPWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwM{mwNlYh|ryP Ml3EV2FPT0WU
SK-LU-1 M{H5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXRe4lvUUN3ME2wMlM6OjB6IN88US=> NHfXTJRUSU6JRWK=
MCF7 NWPjc2R7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\weI1wUUN3ME2wMlQxPTNizszN NXvZUVZuW0GQR1XS
HuO9 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnwNGpKSzVyPUCuOFA3PjdizszN NFTHeFFUSU6JRWK=
BHT-101 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NECyOVZKSzVyPUCuOFA4QDdizszN MYHTRW5ITVJ?
MZ2-MEL M4XTR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFm3XWdKSzVyPUCuOFA5QDJizszN NYDqT5A1W0GQR1XS
NOS-1 NVyxc5NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L5NWlEPTB;MD60NVA4PCEQvF2= MkjRV2FPT0WU
NEC8 M2P3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILNb5lKSzVyPUCuOFE3QTVizszN NXnVO3EyW0GQR1XS
COR-L88 NYTDO3VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjPe3B1UUN3ME2wMlQzOjZ5IN88US=> NUfCNI1NW0GQR1XS
MFM-223 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HPdGlEPTB;MD60NlYyPyEQvF2= MnP3V2FPT0WU
HSC-3 NEi4bZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3IRoU{UUN3ME2wMlQzQTB6IN88US=> M3PTN3NCVkeHUh?=
OVCAR-5 MkfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXXeWRXUUN3ME2wMlQzQTN|IN88US=> NEjtZmJUSU6JRWK=
MFE-280 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH62[2xKSzVyPUCuOFMxOzJizszN MYLTRW5ITVJ?
KP-N-YS M1nNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrNO5RKSzVyPUCuOFMxPyEQvF2= MWrTRW5ITVJ?
EPLC-272H MnH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDXTWM2OD1yLkSzNFc4KM7:TR?= MmjPV2FPT0WU
KE-37 NUSyephnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF6xPJRKSzVyPUCuOFMzPDdizszN NE[zZVhUSU6JRWK=
HuH-7 NWrsS29HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4D4XmlEPTB;MD60N|M4OiEQvF2= M3LFeHNCVkeHUh?=
CHP-212 M{HGNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETwTpFKSzVyPUCuOFM3QTdizszN M1:4d3NCVkeHUh?=
SK-MES-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y2XWlEPTB;MD60N|g1QCEQvF2= NGnQPI9USU6JRWK=
SJSA-1 NWjTTXBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwNES1OVQh|ryP NELueplUSU6JRWK=
QIMR-WIL M1[4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwNEWxOUDPxE1? NVTMSYl3W0GQR1XS
ES4 NXrhPZZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\rZmlEPTB;MD60OVM{PiEQvF2= NH[1NVdUSU6JRWK=
TI-73 NYi5e3ZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjHTWM2OD1yLkS1Olg3KM7:TR?= NXrHc4ViW0GQR1XS
COLO-684 Mki0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwNEW3NlYh|ryP NFj4dmhUSU6JRWK=
GCIY MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwNEW3OVQh|ryP NY\kXJNpW0GQR1XS
JVM-3 NGjOe25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe3e4RKSzVyPUCuOFYzQTJizszN NEX5OGRUSU6JRWK=
MPP-89 NVOwd4NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjnSXhUUUN3ME2wMlQ3QTR5IN88US=> NFn5U2RUSU6JRWK=
M14 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3KOXhiUUN3ME2wMlQ4OTdizszN MmDLV2FPT0WU
SW962 NWLV[oxQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHmSolKSzVyPUCuOFcyQSEQvF2= NGfrfmFUSU6JRWK=
VM-CUB-1 MorKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwNEeyPFYh|ryP NWm4Z2JVW0GQR1XS
A101D NITDPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPYNmRKSzVyPUCuOFg6PjhizszN NWTp[45UW0GQR1XS
DB NEizcJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkD1TWM2OD1yLkWwNFIyKM7:TR?= MUDTRW5ITVJ?
KNS-62 NF3BNYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13yZmlEPTB;MD61NFU3QCEQvF2= NVXzR5JDW0GQR1XS
NCI-H460 NFfPTJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTvcZJKSzVyPUCuOVA2QTdizszN NF3TRpBUSU6JRWK=
MDA-MB-361 NGTyXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrY[XhKSzVyPUCuOVA5PyEQvF2= NHfZNWlUSU6JRWK=
DOK NFvCclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\OTWM2OD1yLkWxN|M{KM7:TR?= NVjoXoN4W0GQR1XS
CAL-39 NUjMSIFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKyZndKSzVyPUCuOVIzPjhizszN MYXTRW5ITVJ?
HT-1080 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS3VVZUUUN3ME2wMlUzPTR|IN88US=> NH7TTJJUSU6JRWK=
GR-ST NHXZOlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX30[ok4UUN3ME2wMlU{ODF3IN88US=> MWjTRW5ITVJ?
J-RT3-T3-5 NWS1c3BOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfSTWM2OD1yLkWzNVk2KM7:TR?= NX3TTG9SW0GQR1XS
NCI-H1793 M4jLdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\2TWM2OD1yLkWzOFQ4KM7:TR?= MXPTRW5ITVJ?
NCI-H1355 NYHxdmcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;iOmlEPTB;MD61N|g4QCEQvF2= NVzWTJFLW0GQR1XS
YH-13 NFu3NYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDiTWM2OD1yLkW0PVM5KM7:TR?= MX\TRW5ITVJ?
LOXIMVI NVrFUGcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPETWM2OD1yLkW1NVI{KM7:TR?= NWjY[5JGW0GQR1XS
ES1 M3vYOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TqPGlEPTB;MD61OVUyQCEQvF2= MnPRV2FPT0WU
GAMG Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwNUW2OVgh|ryP NX7nU5IxW0GQR1XS
SK-MEL-28 MkDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XsWmlEPTB;MD61OVkyKM7:TR?= MkDKV2FPT0WU
KG-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TD[2lEPTB;MD61Olg5PCEQvF2= MWLTRW5ITVJ?
HOS Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwNUexPVIh|ryP MlrvV2FPT0WU
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SW780 NWLqWZpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP6TWM2OD1yLkW3OVk2KM7:TR?= M3nUeHNCVkeHUh?=
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TE-12 NWf6PW5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYj0VIVTUUN3ME2xMlQxPjBzIN88US=> M2\n[XNCVkeHUh?=
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HCC2998 M3SyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjMPJJKSzVyPUGuPVM{OjVizszN MVHTRW5ITVJ?
HEL M2jwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3wNY1KSzVyPUGuPVQyQDRizszN NFnublhUSU6JRWK=
SW684 NXvYb4JDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLCTWM2OD1zLkm3N|cyKM7:TR?= Mm\NV2FPT0WU
NCI-H1693 NYnEOIVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfBe3BKSzVyPUGuPVgxQDZizszN MYjTRW5ITVJ?
8-MG-BA M3rrcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvCU|BGUUN3ME2xMlk5OjFizszN MWLTRW5ITVJ?
OVCAR-8 M33vdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJwMECyPVUh|ryP NUG0PYhzW0GQR1XS
DSH1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\hOWllUUN3ME2yMlAyPzd2IN88US=> NXLDbGlXW0GQR1XS
KYSE-520 NWHPZop5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDyTWM2OD1{LkCyNFQ6KM7:TR?= NH;lfZJUSU6JRWK=
GB-1 NUfobYZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzkTWM2OD1{LkCyOVc4KM7:TR?= MmHlV2FPT0WU
RCC10RGB MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4f3WWlEPTB;Mj6wOFg4OSEQvF2= MlTSV2FPT0WU
SW954 NW[xOpI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJwMEWwN|Yh|ryP MX\TRW5ITVJ?
IST-MES1 M3rLTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fTd2lEPTB;Mj6wOVU3QCEQvF2= NHHOUotUSU6JRWK=
AU565 M4PYU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJwMEW5NFUh|ryP NUS4SXpVW0GQR1XS
CW-2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TtTmlEPTB;Mj6wOlg4PSEQvF2= NUG2b4RYW0GQR1XS
TE-1 MlqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTJwMEmzO|ch|ryP M3Oy[3NCVkeHUh?=
KP-4 NGfEUWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknZTWM2OD1{LkGwN|EzKM7:TR?= MoTjV2FPT0WU
SNU-C2B M2i1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\KVYlKSzVyPUKuNVA5OjNizszN MYXTRW5ITVJ?
NCI-H1395 M3zac2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJwMUC5PFYh|ryP NE\MZZRUSU6JRWK=
CAS-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;rOm1KSzVyPUKuNVE2PDZizszN NX3JPWdUW0GQR1XS
NCI-H1155 NVfzdYozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnBV4pWUUN3ME2yMlIzPjlizszN NWrNbFR[W0GQR1XS
SK-MEL-1 NF3YcY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rUOGlEPTB;Mj6yPFE5OSEQvF2= NUHoXVBKW0GQR1XS
KINGS-1 M2TD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTJwM{CwPFgh|ryP MmjkV2FPT0WU
ESS-1 M1TidGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{juT2lEPTB;Mj6zNFUyKM7:TR?= M2i2XXNCVkeHUh?=
PANC-10-05 NXzEcpdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi5R2VMUUN3ME2yMlM4ODJ2IN88US=> MXfTRW5ITVJ?
HT-1376 NEfiZ2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDjTWM2OD1{LkO4O|A5KM7:TR?= MknnV2FPT0WU
LS-513 MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3P6NGlEPTB;Mj6zPFg4PCEQvF2= MXLTRW5ITVJ?
KNS-42 M{SzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jkVGlEPTB;Mj6zPVExPSEQvF2= MlfGV2FPT0WU
639-V M37mWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJwNEK3OVgh|ryP MnqwV2FPT0WU
SJRH30 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXlZWhKSzVyPUKuOFUyPjFizszN NHHLZoxUSU6JRWK=
SW1783 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXiTVBKSzVyPUKuOFcxPzhizszN NWm0[Gg6W0GQR1XS
NB6 Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jYbmlEPTB;Mj60PFI5KM7:TR?= MXXTRW5ITVJ?
SK-MEL-30 NEX1fopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDn[GVKSzVyPUKuOFg5OyEQvF2= M{fWd3NCVkeHUh?=
HCE-4 NFS1fI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorZTWM2OD1{LkS5OFAzKM7:TR?= NGfRU29USU6JRWK=
NB10 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37l[GlEPTB;Mj60PVQzQSEQvF2= Mo[zV2FPT0WU
H-EMC-SS NXPjXGx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDWTGt5UUN3ME2yMlU1PjVizszN M1XqNnNCVkeHUh?=
SK-HEP-1 NHTxd45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnXOHRMUUN3ME2yMlU2OjN4IN88US=> NXrQUWliW0GQR1XS
HCC1395 NHPtWoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjpe|ltUUN3ME2yMlU2PjV3IN88US=> MXzTRW5ITVJ?
HuCCT1 NE[0SopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX31Z4p[UUN3ME2yMlU3OzlizszN MmPRV2FPT0WU
SiHa NW\RVGN[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnaXVE5UUN3ME2yMlU5PzF7IN88US=> MWfTRW5ITVJ?
EFO-21 M1PaOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJwNUi3OlQh|ryP MmeyV2FPT0WU
NCI-H1666 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Ly[WlEPTB;Mj61PVA4PiEQvF2= M{fxOHNCVkeHUh?=
UMC-11 NGLvWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHWb3FTUUN3ME2yMlU6QDZ6IN88US=> M1WwTnNCVkeHUh?=
COLO-679 NUn2[W0xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvHTWM2OD1{Lk[xNlM{KM7:TR?= MnvkV2FPT0WU
A388 MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XyXGlEPTB;Mj62OVI2OyEQvF2= Mn\YV2FPT0WU
LB2518-MEL NHvYSHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTJwNkW0NFgh|ryP NIrQU|RUSU6JRWK=
EW-13 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;2VmlEPTB;Mj62PFc3QCEQvF2= M3vUeXNCVkeHUh?=
MLMA MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPqdIpKSzVyPUKuOlg5PTZizszN NIjuUVNUSU6JRWK=
HOP-92 NFHMV4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDXOoNKSzVyPUKuO|AyOSEQvF2= MkTIV2FPT0WU
NOMO-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[4TWM2OD1{LkexOFQzKM7:TR?= M2faRnNCVkeHUh?=
NCI-H810 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nuWWlEPTB;Mj63NlE6QCEQvF2= NHTMXmpUSU6JRWK=
769-P NVPSPI5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLNTWM2OD1{LkeyNlgh|ryP NWDsfVV{W0GQR1XS
SAS NWLw[nExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fJSWlEPTB;Mj63OlUh|ryP NV\rRXFxW0GQR1XS
M059J MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJwN{izNVgh|ryP NHHLdHdUSU6JRWK=
RD Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTJwN{m0O|Eh|ryP M4\xd3NCVkeHUh?=
GT3TKB MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX0TWM2OD1{LkizOFM{KM7:TR?= MnHhV2FPT0WU
MZ7-mel MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmOxTWM2OD1{Lki2OVAzKM7:TR?= Ml;lV2FPT0WU
KYSE-510 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDOTWM2OD1{Lki5OVA1KM7:TR?= MkHTV2FPT0WU
NCI-N87 M2HldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvCeFVCUUN3ME2yMlkyQDB5IN88US=> MVvTRW5ITVJ?
MKN1 MlLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX4TWM2OD1|LkCwNVY{KM7:TR?= NH\zNnJUSU6JRWK=
NCI-H2170 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfyfmNbUUN3ME2zMlAxPDVzIN88US=> MnKzV2FPT0WU
OVCAR-3 NGrVfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTNwMEKxNVUh|ryP NHTTWmZUSU6JRWK=
KLE Mn7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHhTWM2OD1|LkC2PFEzKM7:TR?= MXHTRW5ITVJ?
LB771-HNC NYP2cWE5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTNwMEmzOFMh|ryP MmTLV2FPT0WU
MC116 NXXTZWJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv5cY1tUUN3ME2zMlEyOTF{IN88US=> M2LoZnNCVkeHUh?=
SCC-9 NXniTVVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTNwMUGzOlYh|ryP NGK4WG9USU6JRWK=
U031 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTNwMUK0NlMh|ryP NVH4WXVlW0GQR1XS
LCLC-103H NU\mXYp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK4TWM2OD1|LkKzPFk1KM7:TR?= M3m3NXNCVkeHUh?=
U-266 NIfBVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX3eYVQUUN3ME2zMlI4PjN|IN88US=> MXTTRW5ITVJ?
JVM-2 M4TBZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvkeW1OUUN3ME2zMlMzOTZ2IN88US=> NFTZeotUSU6JRWK=
UACC-257 NYrWdHVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTNwNE[0N|Eh|ryP MknjV2FPT0WU
LB996-RCC MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG1fXBKSzVyPUOuOFY2ODJizszN M4HVV3NCVkeHUh?=
BT-549 MofqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXFT5hsUUN3ME2zMlUxOjB7IN88US=> Mly3V2FPT0WU
NCI-H526 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD0fZZ5UUN3ME2zMlU1OTV6IN88US=> MVzTRW5ITVJ?
RH-18 NE\6N3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTNwNkG3PVgh|ryP MXHTRW5ITVJ?
SW626 NEXJOnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TUN2lEPTB;Mz63NVEzQCEQvF2= MYXTRW5ITVJ?
SK-N-AS Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\JOVNHUUN3ME2zMlc{OjR5IN88US=> M4K1dXNCVkeHUh?=
IGR-1 M{DRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfKZ|g2UUN3ME2zMlc1OjR6IN88US=> M4LufHNCVkeHUh?=
NCI-H2291 M1nj[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3WTWM2OD1|Lke1N|M3KM7:TR?= MWPTRW5ITVJ?
NCI-H441 M3X5eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTNwOEK0N|Mh|ryP M32ydHNCVkeHUh?=
D-247MG NWD5c5dyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrnXldKSzVyPUOuPFYxOzFizszN MUDTRW5ITVJ?
COLO-320-HSR M2nwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoOyTWM2OD1|LkmxNlcyKM7:TR?= NYHhUXFlW0GQR1XS
A253 M2LVOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNwOUG0N|Yh|ryP NEfLS4ZUSU6JRWK=
HT55 NXLMZWVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDtNFV2UUN3ME2zMlkyPzd|IN88US=> MmrxV2FPT0WU
MZ1-PC M1i0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzidnNKSzVyPUOuPVU5PjRizszN Mn7mV2FPT0WU
RERF-LC-MS M1X4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjmV45KSzVyPUOuPVY2OjVizszN NHq4V4hUSU6JRWK=
SF268 M4fHNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELxbmNKSzVyPUSuNVI5QDFizszN MYDTRW5ITVJ?
RMG-I NFW1d3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTBTWM2OD12LkKxOFU1KM7:TR?= MX7TRW5ITVJ?
CFPAC-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWH5SXdUUUN3ME20MlIyPjh3IN88US=> NEfPTHRUSU6JRWK=
S-117 NUDFOZlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;1cW9KSzVyPUSuNlIxOjRizszN MnrnV2FPT0WU
NCI-H2122 M2\mUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvycnFKSzVyPUSuN|A6OzFizszN MXnTRW5ITVJ?
J82 NW\pR3pWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXFTWM2OD12LkOzOFQyKM7:TR?= NYL1SIpmW0GQR1XS
CAL-72 Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTRwM{W0O|ch|ryP M3nyd3NCVkeHUh?=
GP5d NH\vWlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET6WWFKSzVyPUSuOFEzQThizszN NI[1T4VUSU6JRWK=
UACC-62 NF;EcYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rrWGlEPTB;ND60OlU1PSEQvF2= MkTjV2FPT0WU
MS-1 MknqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTRwNEmxNVUh|ryP NIfMdlFUSU6JRWK=
RCM-1 M{j2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPGTWM2OD12LkWyPVIh|ryP NG\EcGNUSU6JRWK=
IST-SL1 NFPX[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUG2UZBwUUN3ME20MlY2OzV7IN88US=> MkmyV2FPT0WU
SW756 M2HObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfiR2VTUUN3ME20MlY6OTN3IN88US=> M{fvWXNCVkeHUh?=
HCC38 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTRwN{GxPVch|ryP NUDVeIVWW0GQR1XS
YAPC NWriUnJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37seGlEPTB;ND63NVMyOyEQvF2= MV7TRW5ITVJ?
DK-MG Mo\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTRwN{ixNVIh|ryP NVvQVGI3W0GQR1XS
HCC1937 M2Ozemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDoTlZKSzVyPUSuPFUyOjVizszN M4TySXNCVkeHUh?=
OAW-28 M1PVPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j0OWlEPTB;ND65NlQ{PSEQvF2= NY\RSZl4W0GQR1XS
MEG-01 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGSwOJNKSzVyPUWuNFg{OjhizszN MUTTRW5ITVJ?
GI-1 NWXEPGRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\KcmtKSzVyPUWuNlM1QDZizszN NWTEb3BDW0GQR1XS
FADU MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTVwMke4N|ch|ryP MlPwV2FPT0WU
CAPAN-1 NGK2XopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHCTWM2OD13LkO5OFMzKM7:TR?= MoPIV2FPT0WU
TGBC11TKB Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTVwNEW3PFYh|ryP MmTCV2FPT0WU
DBTRG-05MG MljSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITxZ2dKSzVyPUWuOVA2OiEQvF2= NEfxO2NUSU6JRWK=
ONS-76 M2fIXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\GZ4ZxUUN3ME21MlU2QDBzIN88US=> MnvmV2FPT0WU
Ca-Ski M1\s[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTVwNkK1OlYh|ryP MnHoV2FPT0WU
COLO-741 NV\GXotIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTVwN{G5PVUh|ryP MVPTRW5ITVJ?
HT-29 NU\od5BQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTVwOEC0O|Uh|ryP MVTTRW5ITVJ?
HCC1187 M4D5cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTVwOEGwNFgh|ryP NV7i[o96W0GQR1XS
Capan-2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zSRWlEPTB;NT65OVk6PCEQvF2= MlfHV2FPT0WU
NCI-H630 M1nqWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTZwMUG0OFEh|ryP MVnTRW5ITVJ?
COLO-678 MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H5VmlEPTB;Nj6xOVA6OiEQvF2= NHfyWHpUSU6JRWK=
D-502MG NWHQcJR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PROmlEPTB;Nj6xO|M{PiEQvF2= NGHtcXhUSU6JRWK=
NB17 M3y4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLkOlZKSzVyPU[uNlQ6PDNizszN NUTJfYxbW0GQR1XS
SK-MEL-24 Ml;vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDhTWM2OD14LkK2OFkh|ryP MUnTRW5ITVJ?
NCI-SNU-5 M3noN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW5PW9KSzVyPU[uNlcyOThizszN MkDoV2FPT0WU
D-392MG NUXDVoRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTFTWM2OD14LkOzN|k6KM7:TR?= M1;Re3NCVkeHUh?=
A498 MoDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PyeWlEPTB;Nj60NFMxOiEQvF2= M1q4T3NCVkeHUh?=
OCI-AML2 NUf1R4E6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTZwNEW0OFUh|ryP MoXvV2FPT0WU
HCC2157 M3zEW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPE[FJKSzVyPU[uOFU3OTZizszN MmXMV2FPT0WU
C3A MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXrZZZHUUN3ME22MlUzODB2IN88US=> M4rHR3NCVkeHUh?=
NCI-H1650 NGnO[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrMTWM2OD14LkewOVIzKM7:TR?= NWPr[JdEW0GQR1XS
DU-145 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTZwN{ewN{DPxE1? M{PrWHNCVkeHUh?=
COLO-829 NF:3W|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTZwN{e4O|Mh|ryP NH3PR5BUSU6JRWK=
LS-1034 Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HDcWlEPTB;Nz6wOFQyOiEQvF2= M1LLRXNCVkeHUh?=
HCC1954 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvYfmNqUUN3ME23MlQ5OTN2IN88US=> NXjOdmdMW0GQR1XS
KURAMOCHI NF7o[YFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTdwNEi1N|Mh|ryP M1rwVXNCVkeHUh?=
Mo-T NV\wNJdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLtZpFXUUN3ME23MlUyPDl6IN88US=> Mlj4V2FPT0WU
OE19 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLETWM2OD15Lk[1OVA{KM7:TR?= NGDiS2VUSU6JRWK=
COR-L105 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2myUWlEPTB;Nz63NVQzOSEQvF2= Ml\jV2FPT0WU
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MKN28 M4rISGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRThwMUG1NVUh|ryP NXO2Z3lbW0GQR1XS
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NCI-H226 Ml7vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrldoxKSzVyPUiuOFQ{OzFizszN NV;yNWMzW0GQR1XS
NCI-H2029 MkTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHBTpVzUUN3ME25MlA3PzV7IN88US=> Mn3aV2FPT0WU
TE-11 NXK0OGVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XwcWlEPTB;OT60OVU5QCEQvF2= NH;YUmFUSU6JRWK=
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SW837 M1LJ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvZTWM2OD1zMD6yNlk{KM7:TR?= MoO2V2FPT0WU
NCI-H1651 Ml3TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXsTGdWUUN3ME2xNE4zOzJ4IN88US=> MYDTRW5ITVJ?
NCI-H727 NWn3OoZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPEbHNKSzVyPUGwMlQ1QTVizszN M2DoXHNCVkeHUh?=
NCI-H358 NFrNRXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3qwWGlEPTB;MUCuPFM3PSEQvF2= NHXHcJpUSU6JRWK=
NCI-H2087 NVHVT406T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPod4FZUUN3ME2xNU4xPDN2IN88US=> MXLTRW5ITVJ?
FTC-133 NFPpU5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj4d25KSzVyPUGxMlQxPTFizszN MorUV2FPT0WU
LAN-6 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnlZ5lKSzVyPUGyMlEzPCEQvF2= M{fLV3NCVkeHUh?=
NCI-H1838 NGfZRVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2iwV2lEPTB;MUKuOVE2OSEQvF2= MnX0V2FPT0WU
Calu-6 NX7TcXNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTF2LkGwNlEh|ryP Mn7PV2FPT0WU
HCC70 NFfK[2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HUUGlEPTB;MUSuOFUyKM7:TR?= MUPTRW5ITVJ?
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CAL-27 MkLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHuRVZjUUN3ME2xOU4{QDR|IN88US=> M4XKPXNCVkeHUh?=
NCI-H82 M1LTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPUfGpKSzVyPUG1MlU{OiEQvF2= M3TzSHNCVkeHUh?=
no-10 MmLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDRTWM2OD1zNT65N|gh|ryP M2LNSXNCVkeHUh?=
U251 M1[4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvVTWM2OD1zNj6zOlc2KM7:TR?= MofsV2FPT0WU
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COLO-824 M1noZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofSTWM2OD1{MD65Nlc3KM7:TR?= M2HQPHNCVkeHUh?=
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KALS-1 M2W5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7TTWM2OD1{MT6xO|Uh|ryP NHG0VmhUSU6JRWK=
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ABC-1 Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7RSlhKSzVyPUK2Mlc6PTdizszN MXHTRW5ITVJ?
MHH-NB-11 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPnTWM2OD1|Mz6zOFY1KM7:TR?= NVvqfppoW0GQR1XS
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NB12 NUDvNplOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC5S|RlUUN3ME2zPU41PjV3IN88US=> MVPTRW5ITVJ?
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OCI/AML3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzSNE4zKM7:TR?= MWW0PEBp MVzlcohidmOnczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGmwZIXj[YQh[nlic3XseY1mfGmwaXK= MU[yOFc{QTN7Mx?=
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MCF7-X  NWS0e3dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\ad|lKSzVyPUK0JI5O NX3JPYpVOjR2NUewOlk>
T47D-tamR  Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPQPHZKSzVyPUG5JI5O Mn61NlQ1PTdyNkm=
293T  MojoSpVv[3Srb36gRZN{[Xl? MkfTNlAhdk1? MYmzJIg> NFLUZ4NlcXO{dYD0d{BCc3RvbXXkbYF1\WRiVFnGMWlCKHO2YXLpcIl1gSxidILhcpNtd2OjdHnvckwh[W6mIHHjeIl3cXS7 MnPkNlQ{PjN2NEm=
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Huh7  NU\EVo0zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;LOVUuOTByIH7N NVjFZ453OC1{NDDo MYTEUXNQ Mn\EbY5kemWjc3XzJINmdGxiZHXheIghcW5iYTDjc45k\W62cnH0bY9vNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVz M1vKTFI1Ojl5M{Cw
Hep3B  MmDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[zOU0yODBibl2= M4\sR|AuOjRiaB?= MVPEUXNQ Mke0bY5kemWjc3XzJINmdGxiZHXheIghcW5iYTDjc45k\W62cnH0bY9vNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVz M3nzWFI1Ojl5M{Cw
Huh7  Ml3XSpVv[3Srb36gRZN{[Xl? MVWxNFAhdk1? MWKxNkBp NVnEVVJoTE2VTx?= MnzrbY5lfWOnczDheZRweGijZ4pCpC=> MkXxNlQzQTd|MEC=
U87-MG  M1L0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{KzelczKGh? NEXJfYpIUTVy4pEJQgKBkTd7IH7NxsA> M2nrNVI1OjR7NkSw
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Hep-2 MknBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWwMlAyNTFizszN NYHS[lRoOTJvOU[gbC=> M1vYfIlv[3KnYYPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5meg>? MXyyOFExOzd2OR?=
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Hep-2 MV\GeY5kfGmxbjDBd5NigQ>? NVW3NlNNOC5zL{CuOUDPxE1? MWiyOEBp Mn:1Zoxw[2u|IH3UU3JEOSCjbnSgcXRQWkN{IHHjeIl3[XSrb36= NUX2R2lTOjRzMEO3OFk>
SCC-9 MYnGeY5kfGmxbjDBd5NigQ>? MVWwMlEwOC53IN88US=> M1ixOlI1KGh? MlPVZoxw[2u|IH3UU3JEOSCjbnSgcXRQWkN{IHHjeIl3[XSrb36= NFTo[HQzPDFyM{e0PS=>
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HT-29 MnjHRZBweHSxc3nzJGF{e2G7 MoexNUDPxE1? MkHYO|IhcA>? NF:w[YFifHSnboXheIV{KDVvRmWtbY5lfWOnZDDj[YxtKGSnYYTo M2f3XVIyQTR7MUKx
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Rh30 M3LES2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XJ[mlEPTB;MUSgcm0> NX7GOFY4OjF|M{e2O|k>
BT-12 NWXwTllqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPOTWM2OD1{ND63JI5O M1LhTlIyOzN5Nke5
CHLA-266 M4P2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjUeFI3UUN3ME2xMlEhdk1? M2PjNlIyOzN5Nke5
TC-71 NGf2NWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWGwSnFwUUN3ME20Ok42KG6P MVuyNVM{PzZ5OR?=
CHLA-9 NYryT|g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\0TWM2OD1zNT6zJI5O MlT2NlE{Ozd4N{m=
CHLA-10 NHnP[4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1i1VGlEPTB;Mz65JI5O M1e1U|IyOzN5Nke5
CHLA-258 NHT2Z5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fCSGlEPTB;MUCuOEBvVQ>? NVvtVHVbOjF|M{e2O|k>
GBM2 NULVPW45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PxU2lEPTB;NECuO{BvVQ>? MlvqNlE{Ozd4N{m=
NB-1643 NUGyTYlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX4N3o6UUN3ME2zN{45KG6P M3O4bVIyOzN5Nke5
NB-EBc1 M1u4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPRSox4UUN3ME2yO{4yKG6P MYmyNVM{PzZ5OR?=
CHLA-90 NH\VfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1r4SGlEPTB;M{SuOUBvVQ>? MnnRNlE{Ozd4N{m=
CHLA-136 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TmUGlEPTB;MU[yMlYhdk1? NH7k[FUzOTN|N{[3PS=>
NALM-6 Ml7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrWZYtrUUN3ME2zNk46KG6P NXP4epB6OjF|M{e2O|k>
COG-LL-317 NGPnO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFwMzDuUS=> MoH2NlE{Ozd4N{m=
RS4;11 Mn7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\NUWlKSzVyPUO1JI5O M4fTVVIyOzN5Nke5
MOLT-4 M3LLcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHvTWM2OD16Lk[gcm0> NHXM[5czOTN|N{[3PS=>
CCRF-CEM NWTPNGp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILYcItKSzVyPUSuNUBvVQ>? Mk[1NlE{Ozd4N{m=
Kasumi-1 NFqzWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTFwNDDuUS=> M3vWcVIyOzN5Nke5
Karpas-299 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2H5dmlEPTB;MkGuO{BvVQ>? NVTEWZFEOjF|M{e2O|k>
Ramos-RA1 M1LrNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRThwMjDuUS=> MVuyNVM{PzZ5OR?=
H838 NU\mc3l{TnWwY4Tpc44hSXO|YYm= NYfwfYpkOSEQvF2= M4fqZ|Q5KGh? NH7keHdqdmS3Y3XzJINmdGxiYYX0c5Bp[We7 M2nO[VIxOzZ2MUGz
H838 MlHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUiwMVMh|ryP MYm3NkBp NHfMS5dqdmS3Y3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CCjdYTvdIhi\3l? M2LiTVIxODJ6OEW0
A549  MnO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X3fVAuOyEQvF2= NXXQe5ZJPzJiaB?= MWTpcoR2[2W|IHfyc5d1cCCrbnjpZol1cW:wIHHu[EBifXSxcHjh[5k> NVfaVWJmOjByMki4OVQ>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-mTOR / p-AKT / p-4EBP1 / p-P70S6K / p-PRAS40; 

PubMed: 24457069     


Western blots of 70% confluent TamR (A) and MCF7-X (B) cells treated for 15 minutes to 24 hours with AZD8055 (0 to 100 nM). Blots were probed with phospho- and total antibodies for mTORC1 and two signalling pathways. In both cell lines mTORC1 and mTORC2 s䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙

p-EGFR / EGFR; 

PubMed: 25654224     


PANC-1 cells were treated with AZD8055 for the indicated hours and EGFR (T/P), AKT (T/P) and ribosomal protein S6 (S6) (T/P) proteins were examined by western-blot;

p-FOXO1 / FOXO1 / p-FOXO3a / FOXO3a ; 

PubMed: 25654224     


PANC-1 cells were transfected with FoxO1/FoxO3a siRNAs and treated with AZD8055 for 1 h, then AKT (T/P), FoxO1 (T/P), FoxO3a (T/P) and EGFR (T/P) proteins were examined by western-blot.

24457069 25654224
Immunofluorescence
p-4EBP1 / EIF4E / mTOR; 

PubMed: 24600487     


(C) Hoechst 33258 staining of Hep-2 cells after treatment with AZD8055 for 24 hours were shown. The cells were fixed and immunereacted with anti-mTOR antibody followed by incubation with Alexa 488-labeled secondary antibody (C-F). Images were taken by a c䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à㺣痖�෋€𢡄�෋€䀷痗�෋౴�෋㵶痗�෋뺖᎒泌Itemセ᎒Count﫨呂�෋猴፲�෋፲씢痗猸፲髸莤䥷堙᎒セ᎒�堞ﻮ᎒፲露𢡄堚،齃礤v�堞ﻮ᎒猢Wセ᎒䨼Ą鹿齃殺獸W戀醙玛W戀ⶰ໯齃礤v 玚W玢Wⶰ໯﫰礌vtЉᔈැ鲬౴᥊疜犈፲Eo狜፲艘ᎂ艘ᎂ⩈̎䥠̌씢痗狠፲붖᎒i變ﱘ﫰﬐먙堘붖᎒狠፲i變ﱘ﫰먰堘ﱘ붖᎒�堞봆᎒릎堘붖᎒i꣩쯟巰痗ꣵ쯟巰痗Љ镴౴￿￿嶴痗Љ镨౴ᔈැ竗ᔈැ屷痗W竗尊痗

LC3B / p62 ; 

PubMed: 30337536     


Immunofluorescence staining of U87 and U251 GICs, which treated by DMSO, AZD8055 (0.3 μM) and rapamycin (3 μM). The nuclei were stained with DAPI and the antibody against LC3B and p62. Images were captured by laser confocal microscope ( × 400), scale bar 䲧疝Ỵ疞

24600487 30337536
Growth inhibition assay
Cell viability ; 

PubMed: 29263324     


Growth for the indicated cell lines was assessed after 72 h of treatment with AZD8055 (0–250 nM). Results are expressed as a percentage of cell number relative to the DMSO-treated control cells a.

29263324
In vivo AZD8055 inhibits the pS6 and pAkt in U87MG and A549 xenografts at 2.5/10 mg/kg, which leads to tumor growth inhibition. AZD8055 shows significant antitumor activity in many xenografts, including U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA at a dose of 10/20 mg/kg. [1] AZD8055 induces ~40% reduction in tumour volume, accompanied by ablation of phosphorylation of Akt, S6K and SGK protein kinases. Administration of AZD8055 (5mg/kg, Bid) and SAHA (100 mg/kg/d) results in complete tumor growth inhibition in PTEN+/−LKB1+/hypo xenografts without side effects on mice by inhibition of mTORC1 and mTORC2 signaling. [4]

Protocol

Kinase Assay:[1]
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Cell-based determinations of mTOR inhibition:

A high-throughput screening cell-based assay is developed using MDA-MB-468 cells to detect mTORC1 and mTORC2 activity. Cells are exposed for 2 hours to increasing concentrations of AZD8055. At the end of the incubation period, cells are fixed, washed, and probed with antibodies against S473 pAkt or against S235/236 phosphorylated S6 (pS6). Levels of phosphorylation are assessed using an Acumen laser scanning cytometer.
Cell Research:[1]
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  • Cell lines: U87MG, A549 and H838 cells
  • Concentrations: 1 nM - 1 μM
  • Incubation Time: 72 to 96 hours
  • Method: Cells are exposed to AZD8055 for 72 to 96 hours and stained for cell nuclei (0.03 mg/mL Hoechst 33342) and acidic vesicles (1 μg/mL acridine orange). Images are captured at 450 and 536 nm on an ArrayScan II platform, and the percentage of acidic vesicles and the number of cells are quantified. For LC3 assessment, cells are exposed to e64d/pepstatin (10 μg/mL) for 30 to 90 min before incubation with AZD8055. Cells are lysed on ice and analyzed by immunoblotting.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG and A549 are established in pathogen-free, female nude mice (nu/nu:Alpk).
  • Dosages: 2.5-20 mg/kg
  • Administration: Oral gavage once or twice daily
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL warmed (107.4 mM)
Water Insoluble
Ethanol '3 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 465.54
Formula

C25H31N5O4

CAS No. 1009298-09-2
Storage powder
in solvent
Synonyms N/A
Smiles CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOCC5C

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID