AZD8055

Catalog No.S1555

Molecular Weight(MW): 465.54

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

Cited by 38 Publications

Nat Med, 2015, 10.1038/nm.3855

PubMed: 25939062

Cancer Cell, 2015, 27(1):97-108

PubMed: 25544637

Cancer Cell, 2015, 27(4):533-46

PubMed: 25873175

J Clin Invest, 2014, 10.1172/JCI73935

PubMed: 25415435

Genome Biol, 2016, 17(1):149

PubMed: 27380875

Nat Commun, 2014, 5:3384

PubMed: 24594970

Autophagy, 2012, 9(1):74-92

PubMed: 23196898

Cancer Res, 2014, 74(10):2846-56

PubMed: 24614082

Cancer Res, 2014, 74(14):3947-58

PubMed: 24986516

Cancer Res, 2013, 73(11):3402-11

PubMed: 23585456

Cell Rep, 2015, 11(3):446-59

PubMed: 25865887

Int J Cancer, 2014, 10.1002/ijc.28880

PubMed: 24706460
Antioxid Redox Sign, 2014, 20(9):1382-95

PubMed: 24063548

Am J Transplant, 2013, 13(8):2035-43

PubMed: 23841834

Mol Cancer Ther, 2013, 13(1):37-48

PubMed: 24233399

Cell Commun Signal, 2017, 10.1186/s12964-017-0164-3

PubMed: 28143584

Mol Oncol, 2013, 33:404-18

PubMed: 24444656

Mol Cell Proteomics, 2014, 13(6):1429-38

PubMed: 24643969

Clin Sci, 2015, 128(8):517-26

PubMed:

Mol Cancer Res, 2015, 13(2):223-30

PubMed:

Mol Cancer Res, 2015, 13(1):120-9

PubMed:

Exp Neurol, 2012, 233(2):799-806

PubMed: 22177999

Biochem Pharmacol, 2012, 83(9):1183-94

PubMed: 22305748

J Biol Chem, 2015, 10.1074/jbc.C114.627778

PubMed: 25833948
J Biol Chem, 2013, 288(49):35287-96

PubMed: 24133218

Am J Cancer Res, 2014, 4(6):824-837

PubMed:

Biochem J, 2015, 465(2):227-38

PubMed: 25353634

Mol Cell Biol, 2014, 34(13):2517-32

PubMed: 24777602

J Chromatogr A, 2015, 1388:267-73

PubMed:

Proteomics, 2015, 10.1002/pmic.201400586

PubMed: 25764225

Mol Biol Cell, 2013, 24(23):3736-45

PubMed: 24088573

Mol Reprod Dev, 2014, 81(7):655-65

PubMed: 24753052

PLoS One, 2016, 11(4):e0154564

PubMed: 27128484

PLoS One, 2013, 8(2):e56567

PubMed: 23451056

Biochem Biophys Res Commun, 2013, 440(4):701-6

PubMed: 24103749

Oncol Lett, 2013, 5(2):717-721

PubMed: 23420667
Oncotarget, 2014, 5(21):10732-44

PubMed: 25313141

Oncotarget, 2014, 5(15):6015-27

PubMed: 24970798

8 Customer Reviews

PC3-LN4 cells were treated with GSK690693 (5 uM) alone, or in combination with PP242 (2 uM) or AZD8055 (1 uM) for 24 h, and immunoblotting performed.

Cancer Res 2013 73(11), 3402-11. AZD8055 purchased from Selleck.

mTOR kinase inhibitor AZD8055 activates PI3K accompanied with induction of expression of EGFR, HER2, HER3 and IRS1. Serum-deprived CHO-EGFP-AKT cells were incubated with 50 nM AZD8055 for 24 hr. The EGFP signal was detected using confocal microscopy. The white arrows indicate EGFP-AKT located on cellular membrane.

Int J Cancer 2014 135(10), 2462-74. AZD8055 purchased from Selleck.
HUVEC were treated with either RAD001 or AZD8055 before PA treatment. p53, GPX1, p53 acetylation, and subcellular PTEN were analyzed with corresponding antibodies. The blot is a representative of the results of three experiments. Values (mean盨D) are expressed as fold over untreated control. *p<0.05 versus their corresponding control groups in the one-way ANOVA.

Antioxid Redox Signal 2014 20(9), 1382-95. AZD8055 purchased from Selleck.

CSCs^+24/44/ESA at 5,000 cells per well with stem cell culture media in triplicate in an ultra-low adhesion plate were treated with 5 umol/L BMS-777607, 1 umol/L AZD8055 alone, or in their different combinations. Cells were cultured for 72 hours. Cell viability was determined by the MTS assay. Percentages of polyploid cells were determined by counting 300 cells from two different regions. Results shown here were from one of two experiments with similar results.

Mol Cancer Ther 2014 13(1), 37-48. AZD8055 purchased from Selleck.
mTOR, P70S6K1, 4E-BP1 and PCNA activation in the basilar artery of SAH. Top, Western blotting bands of antibodies, bottom, density of the protein band from each group. A, mTOR activation in the basilar artery demonstrated an elevated expression of mTOR on day 7 following SAH in SAH and SAH+DMSO animals. The mTOR inhibitors, Rapamycin and AZD8055 reduced the enhanced expression of mTOR (pb0.05, ANOVA). B. P70S6K1 activation. C. 4E-BP1 activation. D. PCNA activation. Rapamycin and AZD8055 significantly decreased the expression of P70S6K1, 4E-BP1 and PCNA compared with the SAH and SAH+DMSO (pb0.05, respectively; ANOVA). There was no significant difference between the two inhibitors in mTOR, P70S6K1, 4E-BP1 and PCNA expression.

Exp Neurol 2012 233, 799-806. AZD8055 purchased from Selleck.

Induction of TCTP expression through 5-FU or oxaliplatin is inhibited by mTOR kinase inhibitors. HCT116 cells were treated for 48 h with 5-FU or oxaliplatin at the indicated concentrations. Where indicated, AZD 8055 (100 nM) or PP242 (1 μM) were added. TCTP levels were assessed by western blotting; signals were quantified and normalised against α-tubulin as a loading control. As a readout of mTOR activity, phosphorylation of the ribosomal protein S6 at Ser 240/244 was assessed using a phospho-specific antibody. a. Representative western blots demonstrating the alteration of the levels of TCTP protein and of phospho-ribosomal protein S6, respectively, in relation to the drug concentration.

Cell Commun Signal, 2017, 15(1):9. AZD8055 purchased from Selleck.
(A) HCT116 or MDA-MB-468 cells were treated with 500 nM AZD8055 for the indicated times. Cell lysates were immunoblotted with the indicated antibodies. (B) HCT116 or MDA-MB-468 cells were treated with 50 nM rapamycin. 500 nM AZD8055, 1 uM MK2206 or dimethyl sulfoxide (DMSO) as control for 12 h. Cell lysates were immunoblotted with the indicated antibodies.

Oncotarget 2014 5(15), 6015-27. AZD8055 purchased from Selleck.

After starved in serum-free medium for 24h , A549 cells incubated with the indicated concentrations of AZD8055 for 3h , followed by 20-minute stimolation of 100ng/ml EGF

Dr. Zhang of Tianjin Medical University. AZD8055 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

Features

First drug to inhibit both types of mTOR protein.

Targets

mTOR (truncated) ^[1] (MDA-MB-468 cells)	mTOR (full length) ^[1] (MDA-MB-468 cells)
0.13 nM	0.8 nM

In vitro

AZD8055 shows low activity (∼1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells. ^[1] AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. ^[2] AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7 nM and induces significant differences in EFS distribution. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
LU-139	NVvQNGZsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3\ldWlEPTB;MD6wNlM{OSEQvF2=	M2n3XnNCVkeHUh?=
NCI-H720	NWTa[FZLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml\QTWM2OD1yLkCyPVM5KM7:TR?=	NELpWYdUSU6JRWK=
KARPAS-45	M1rxU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIPxb4tKSzVyPUCuNFM{PzFizszN	MmfsV2FPT0WU
EW-3	NX3VSGdqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWDLPGd3UUN3ME2wMlA1ODV4IN88US=>	NHnneYJUSU6JRWK=
SBC-1	NVnMbG91T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWrQcWkzUUN3ME2wMlA1PThzIN88US=>	NUnFVohpW0GQR1XS
NCI-H209	M2\FV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVWwco1uUUN3ME2wMlA2PDV\|IN88US=>	MlXTV2FPT0WU
EoL-1-cell	M4jhRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVHSOnNwUUN3ME2wMlA3PTZ7IN88US=>	MknaV2FPT0WU
H9	NVTxcHJCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml7sTWM2OD1yLkC2OlkzKM7:TR?=	MUnTRW5ITVJ?
AN3-CA	NXHlTHRjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MojzTWM2OD1yLkC3PVUyKM7:TR?=	M4rDcXNCVkeHUh?=
HH	NFHkfZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFSyOZJKSzVyPUCuNFgxODlizszN	NF71SJdUSU6JRWK=
KU812	NVTh[pBMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX7JR\|UxRTBwMEiwOFMh\|ryP	Mn3zV2FPT0WU
DU-4475	NHmxOppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml7lTWM2OD1yLkC4NFQ4KM7:TR?=	MojUV2FPT0WU
CTV-1	MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NU[wW\|R3UUN3ME2wMlA5PjRzIN88US=>	NWniZpdEW0GQR1XS
BV-173	NIDMO41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVXJR\|UxRTBwMEmwOlEh\|ryP	NYK4U4h1W0GQR1XS
ES5	M331PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX;JR\|UxRTBwMEmzOUDPxE1?	M{\QNXNCVkeHUh?=
G-402	NWPrNFljT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NU\WTZZVUUN3ME2wMlA6QThizszN	M{WxOXNCVkeHUh?=
MV-4-11	NFe1bY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEXnXJZKSzVyPUCuNVA{PDdizszN	NIfVPItUSU6JRWK=
NB69	M4LZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{LhZmlEPTB;MD6xN\|Uh\|ryP	NELNZZVUSU6JRWK=
EGI-1	MofHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{fMWWlEPTB;MD6xN\|U{OSEQvF2=	M{\PcHNCVkeHUh?=
EW-18	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXrJR\|UxRTBwMUSwO\|Mh\|ryP	M4DlTnNCVkeHUh?=
ME-180	NWnVdmZoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoX6TWM2OD1yLkG0OlgyKM7:TR?=	M1H1[nNCVkeHUh?=
D-283MED	NVu2Z2RNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWXJR\|UxRTBwMUS3NlMh\|ryP	MlOxV2FPT0WU
NB14	NVvQN4c1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVXJR\|UxRTBwMU[0OFch\|ryP	M4fYdHNCVkeHUh?=
Ramos-2G6-4C10	M4e3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXXSbFJsUUN3ME2wMlE3QTh\|IN88US=>	MkLRV2FPT0WU
NBsusSR	Mn3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3XYXmlEPTB;MD6xO\|AyQSEQvF2=	NV\r[ZduW0GQR1XS
LAMA-84	NFzIV3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml2yTWM2OD1yLkG4NFMzKM7:TR?=	MmLUV2FPT0WU
NCI-H1581	M4nsdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NW\wVnd3UUN3ME2wMlE5QTZ4IN88US=>	MmLMV2FPT0WU
A204	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1jOeGlEPTB;MD6xPFk4KM7:TR?=	M2T2bXNCVkeHUh?=
A549	NYjyNVRPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXrQXYtjUUN3ME2wMlE6PTVizszN	MV3TRW5ITVJ?
CAL-51	MlHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoLmTWM2OD1yLkG5OlUyKM7:TR?=	NITW[FdUSU6JRWK=
NKM-1	M2PwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2XFTmlEPTB;MD6yNFAzQSEQvF2=	M1XXZXNCVkeHUh?=
LoVo	M3fiNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M37yVmlEPTB;MD6yNFIxOiEQvF2=	NV7q[442W0GQR1XS
HAL-01	M4DEUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3S3dmlEPTB;MD6yNFI6PyEQvF2=	M{\mUXNCVkeHUh?=
HCC2218	NGXCT3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mm\vTWM2OD1yLkKwOlg5KM7:TR?=	M1LrdHNCVkeHUh?=
BEN	NEjkdGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NU\mVIx2UUN3ME2wMlIyOjl\|IN88US=>	M3Lr[HNCVkeHUh?=
LC-2-ad	M4GxeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX;JR\|UxRTBwMkKwPFQh\|ryP	MnzYV2FPT0WU
LXF-289	M17tT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NULNdGlYUUN3ME2wMlI2ODRzIN88US=>	MWPTRW5ITVJ?
HGC-27	M3;XZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4fmRmlEPTB;MD6yOlQyPCEQvF2=	M4jqZnNCVkeHUh?=
LK-2	Mn7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVPJR\|UxRTBwMk[4NlQh\|ryP	NX;wbWx2W0GQR1XS
CTB-1	Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mm\hTWM2OD1yLkK3NlE2KM7:TR?=	M1TIWXNCVkeHUh?=
697	NV7UZZNET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUDJR\|UxRTBwMkezOlch\|ryP	Ml65V2FPT0WU
ES7	M3HH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH7HZ3JKSzVyPUCuNlc{QDNizszN	M2jhSHNCVkeHUh?=
MG-63	NUCwc\|lMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkLDTWM2OD1yLkK3OFA4KM7:TR?=	M3;Y[nNCVkeHUh?=
T47D	NI\zdXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{C4W2lEPTB;MD6yO\|Q4PSEQvF2=	NFu0S\|BUSU6JRWK=
RPMI-8226	Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4fpV2lEPTB;MD6yPFU5QSEQvF2=	NVy0W2FoW0GQR1XS
NCI-H292	NE\RO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXLJR\|UxRTBwMkmxOlQh\|ryP	M3O4[HNCVkeHUh?=
HT	M2rYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGK4d\|hKSzVyPUCuNlk{QCEQvF2=	M1PQPXNCVkeHUh?=
A3-KAW	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4jTVGlEPTB;MD6yPVc1KM7:TR?=	NWrSOI5ZW0GQR1XS
LB2241-RCC	M3nPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYnIdIdyUUN3ME2wMlMxOTl6IN88US=>	Mn3vV2FPT0WU
BB65-RCC	MmXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYnJR\|UxRTBwM{C4NFUh\|ryP	M3\VWHNCVkeHUh?=
G-401	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mnz6TWM2OD1yLkOwPVg3KM7:TR?=	MWjTRW5ITVJ?
TYK-nu	M3r0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXSxeIdiUUN3ME2wMlMyQDZ2IN88US=>	M{HUNHNCVkeHUh?=
NCI-SNU-1	M3uwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVfs[mdWUUN3ME2wMlMzOzNzIN88US=>	MXLTRW5ITVJ?
CHL-1	Mki4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmP2TWM2OD1yLkOyO\|A{KM7:TR?=	MU\TRW5ITVJ?
P30-OHK	M4j4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUPmcJU4UUN3ME2wMlMzPzB3IN88US=>	MnXZV2FPT0WU
PA-1	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmqwTWM2OD1yLkOzOlE6KM7:TR?=	MljkV2FPT0WU
LB1047-RCC	NUH6fWdLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIrWcYVKSzVyPUCuN\|QxPDdizszN	M120XHNCVkeHUh?=
EM-2	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVLJR\|UxRTBwM{SxPFgh\|ryP	Mm\iV2FPT0WU
VA-ES-BJ	NXuwbXc3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1nNU2lEPTB;MD6zOFI3QCEQvF2=	NFrn[HRUSU6JRWK=
NCI-H520	NILOVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIrH[lJKSzVyPUCuN\|Q5OzRizszN	NYf0SlZbW0GQR1XS
ECC10	Mn3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHz0[YZKSzVyPUCuN\|UxOzVizszN	MmnoV2FPT0WU
LNCaP-Clone-FGC	NGHBSYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1zNW2lEPTB;MD6zOVMyPCEQvF2=	NU\FNno2W0GQR1XS
ES8	NXPaNJhyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2PncGlEPTB;MD6zOlU2OyEQvF2=	MlqwV2FPT0WU
HuO-3N1	M3fNWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUTJR\|UxRTBwM{izO\|kh\|ryP	MUjTRW5ITVJ?
L-363	NWm1WVc5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVnJR\|UxRTBwM{mwNlYh\|ryP	NFvGNlFUSU6JRWK=
SK-LU-1	MlXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX7JR\|UxRTBwM{myNFgh\|ryP	NWXiWld{W0GQR1XS
MCF7	NIG3SXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWexPXBCUUN3ME2wMlQxPTNizszN	MnTQV2FPT0WU
HuO9	Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MW\JR\|UxRTBwNEC2Olch\|ryP	M4jkVXNCVkeHUh?=
BHT-101	M4S2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIfUOnJKSzVyPUCuOFA4QDdizszN	NXmxPZhJW0GQR1XS
MZ2-MEL	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHrZe2VKSzVyPUCuOFA5QDJizszN	M3:5OnNCVkeHUh?=
NOS-1	MlnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIDrNVZKSzVyPUCuOFExPzRizszN	Ml3aV2FPT0WU
NEC8	M1\qPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3zCVmlEPTB;MD60NVY6PSEQvF2=	M1L4Z3NCVkeHUh?=
COR-L88	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFz5XnNKSzVyPUCuOFIzPjdizszN	NVy4XHhTW0GQR1XS
MFM-223	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFzCTppKSzVyPUCuOFI3OTdizszN	NIO4T3ZUSU6JRWK=
HSC-3	NHS5UpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF;mT\|dKSzVyPUCuOFI6ODhizszN	M2e4R3NCVkeHUh?=
OVCAR-5	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{eyS2lEPTB;MD60Nlk{OyEQvF2=	MXrTRW5ITVJ?
MFE-280	NEGwcplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MofQTWM2OD1yLkSzNFMzKM7:TR?=	NIPuT\|NUSU6JRWK=
KP-N-YS	NFPnNFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVjJR\|UxRTBwNEOwO{DPxE1?	MWTTRW5ITVJ?
EPLC-272H	NU\lRnFsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlXLTWM2OD1yLkSzNFc4KM7:TR?=	NYHuRVVmW0GQR1XS
KE-37	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWrSbpFyUUN3ME2wMlQ{OjR5IN88US=>	M1fEenNCVkeHUh?=
HuH-7	NFLEZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3LQOmlEPTB;MD60N\|M4OiEQvF2=	NUnx[4hQW0GQR1XS
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NCI-H1648	NILvUoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlXETWM2OD1yLkewNVc{KM7:TR?=	M3:yUXNCVkeHUh?=
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NCI-H747	M3yweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mle0TWM2OD1yLke1PVkyKM7:TR?=	NX:wV5N[W0GQR1XS
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OVCAR-4	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHvQ[opKSzVyPUCuPFE6OTFizszN	MlT0V2FPT0WU
NCI-H2347	M{PrXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4q1VmlEPTB;MD64NlQxOSEQvF2=	MVfTRW5ITVJ?
OCUB-M	NGnXRpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mo[zTWM2OD1yLkiyOlc2KM7:TR?=	MX7TRW5ITVJ?
KYSE-450	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFHmNlNKSzVyPUCuPFI4OjVizszN	MVXTRW5ITVJ?
PFSK-1	MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MojUTWM2OD1yLkizNFM6KM7:TR?=	M1HhR3NCVkeHUh?=
A431	M3rNSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWL5OnlqUUN3ME2wMlg{OTF4IN88US=>	NXLsXY5DW0GQR1XS
MHH-ES-1	NI\HZ4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV3IdYZJUUN3ME2wMlg{PDV5IN88US=>	M1TsN3NCVkeHUh?=
HD-MY-Z	MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MonJTWM2OD1yLki0NFkzKM7:TR?=	M2nFSnNCVkeHUh?=
RT-112	M2flZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWjJR\|UxRTBwOES5N\|ch\|ryP	MnnxV2FPT0WU
KU-19-19	Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEfJSWlKSzVyPUCuPFUyOjFizszN	MUXTRW5ITVJ?
HCC1569	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVH5dG83UUN3ME2wMlg2OjB5IN88US=>	MVXTRW5ITVJ?
RPMI-8866	M3Tpc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFjrTlhKSzVyPUCuPFU5OjJizszN	M{e1dXNCVkeHUh?=
CAL-120	NEXIPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlfMTWM2OD1yLki2NFQyKM7:TR?=	MXzTRW5ITVJ?
CAL-33	NVL0RplrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIHWTZhKSzVyPUCuPFY1QTVizszN	Mn7QV2FPT0WU
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HCC1419	MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4TUTmlEPTB;MD64OlkzQCEQvF2=	MVrTRW5ITVJ?
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BxPC-3	NFHTSndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXrJR\|UxRTBwOEi4N\|Mh\|ryP	MV3TRW5ITVJ?
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NCI-H1573	NUDocm9lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX\JR\|UxRTBwOUCyNlkh\|ryP	M2TYXXNCVkeHUh?=
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UACC-893	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoPTTWM2OD1yLkmyPFU2KM7:TR?=	Mn3tV2FPT0WU
RXF393	MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2rtV2lEPTB;MD65Nlg6PyEQvF2=	M1nobXNCVkeHUh?=
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HCC1806	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NETLbVhKSzVyPUCuPVMzPTZizszN	Mmm0V2FPT0WU
DMS-114	NHi0bXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4nDUGlEPTB;MD65N\|Y4PyEQvF2=	M2KyXnNCVkeHUh?=
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ACN	NFS1R\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH\pRlBKSzVyPUCuPVQzPzdizszN	MYLTRW5ITVJ?
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DEL	NH\EO4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYO2UpZDUUN3ME2wMlk3Pzd\|IN88US=>	MUHTRW5ITVJ?
NCI-H1792	NY\Fd\|ZET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUPJR\|UxRTBwOUexNFEh\|ryP	M{H1W3NCVkeHUh?=
A2058	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIHh[mdKSzVyPUCuPVc{PiEQvF2=	MXHTRW5ITVJ?
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LU-134-A	MlfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{DkXGlEPTB;MT6wNlY4PSEQvF2=	NHv3THdUSU6JRWK=
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PANC-03-27	M2PxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MljvTWM2OD1zLkCzNVQyKM7:TR?=	Ml\QV2FPT0WU
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KOSC-2	M33DWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXjJR\|UxRTFwMEiwNlEh\|ryP	M4WyUHNCVkeHUh?=
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AGS	MlTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGrFO\|VKSzVyPUGuNFk1PTlizszN	M4ewfnNCVkeHUh?=
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KYSE-180	MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MV3JR\|UxRTFwMUGwNlEh\|ryP	M3exOnNCVkeHUh?=
NH-12	NFHJU3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3LEcmlEPTB;MT6xNVI{PyEQvF2=	MlTXV2FPT0WU
BE-13	NXe1bmdbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVvabGJ6UUN3ME2xMlEyPzV7IN88US=>	MWXTRW5ITVJ?
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NCI-H1092	MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEjqOFZKSzVyPUGuNVM1KM7:TR?=	MV7TRW5ITVJ?
NCI-H1755	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4\pO2lEPTB;MT6xN\|k1OSEQvF2=	NVS5eY9CW0GQR1XS
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NB13	NF[4[\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmDqTWM2OD1zLkG0OFUh\|ryP	NYDnWm06W0GQR1XS
NCI-H2405	M1y5TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWjJR\|UxRTFwMUS1O\|Qh\|ryP	MmPhV2FPT0WU
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MDA-MB-453	Mkj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{XYWWlEPTB;MT6xOVYzPCEQvF2=	NX\MUGJKW0GQR1XS
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HT-144	M3v0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mlj5TWM2OD1zLkG3NFch\|ryP	NIHWcHRUSU6JRWK=
HEC-1	MljPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVTJR\|UxRTFwMUe2Nlch\|ryP	NXzUPJNwW0GQR1XS
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HDLM-2	M4fT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlzRTWM2OD1zLkKxN\|I3KM7:TR?=	M{ixRXNCVkeHUh?=
MKN7	NEP6[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M364RmlEPTB;MT6yNVcxOiEQvF2=	MkfYV2FPT0WU
MDA-MB-415	NVnOOpU{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXvJR\|UxRTFwMkG3NFIh\|ryP	MYPTRW5ITVJ?
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NCI-H2030	NUHkcIJyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3e1eWlEPTB;MT6yOFExPiEQvF2=	MlzxV2FPT0WU
LS-123	NFXyUIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{fC[WlEPTB;MT6yOFc2OyEQvF2=	MUPTRW5ITVJ?
SK-MEL-3	NV\0OW5KT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3nzdGlEPTB;MT6yOFc4PiEQvF2=	MWfTRW5ITVJ?
KS-1	MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF3iWVdKSzVyPUGuNlUyPzFizszN	NFHuOXZUSU6JRWK=
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NCI-H596	NFPrVnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1vvOWlEPTB;MT6yOVkzQSEQvF2=	NX[5fFJTW0GQR1XS
KYSE-410	MkDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGS1T3dKSzVyPUGuNlcxOTRizszN	MX;TRW5ITVJ?
NCI-H2228	MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MV\JR\|UxRTFwMkexOlch\|ryP	NWjrO41TW0GQR1XS
LN-405	NXzaWJBjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M13Ie2lEPTB;MT6yPFAzOSEQvF2=	MXjTRW5ITVJ?
8505C	MkjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3LDS2lEPTB;MT6yPFgzOyEQvF2=	MlK5V2FPT0WU
BFTC-909	NE\GV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MULJR\|UxRTFwMkm0N\|Qh\|ryP	MkfzV2FPT0WU
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NMC-G1	M3S2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkHsTWM2OD1zLkOxNVM2KM7:TR?=	NV7KfFFRW0GQR1XS
SKG-IIIa	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWnJR\|UxRTFwM{G0Nlgh\|ryP	M1rlUnNCVkeHUh?=
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NCI-H446	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUXJR\|UxRTFwM{K5NFIh\|ryP	M12ySXNCVkeHUh?=
TGBC1TKB	MkHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlO4TWM2OD1zLkOyPVk5KM7:TR?=	Mk\wV2FPT0WU
GCT	NXy3S4FoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmD6TWM2OD1zLkO0N\|Q2KM7:TR?=	M4XCOXNCVkeHUh?=
COR-L23	Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWXJR\|UxRTFwM{S4OFUh\|ryP	NYD4UHdHW0GQR1XS
TK10	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2XkTmlEPTB;MT6zOVc6PyEQvF2=	MWDTRW5ITVJ?
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SW1088	Mln6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlX1TWM2OD1zLkO2OlEzKM7:TR?=	NVrWW4NVW0GQR1XS
AM-38	NHnMbG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWXJR\|UxRTFwM{exPVkh\|ryP	NX7C[oh5W0GQR1XS
CHP-134	NF\COpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWnJR\|UxRTFwM{e4OFQh\|ryP	MkewV2FPT0WU
SW872	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3HQ[WlEPTB;MT6zPFU2PSEQvF2=	NIrQcHNUSU6JRWK=
LB831-BLC	NFvpVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWj6VXo{UUN3ME2xMlM6ODZ5IN88US=>	NWfvOI05W0GQR1XS
TE-12	Mof1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2jzeGlEPTB;MT60NFYxOSEQvF2=	NUK1ZpRrW0GQR1XS
LCLC-97TM1	NIDzcZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3mwOmlEPTB;MT60NVA1PiEQvF2=	MWLTRW5ITVJ?
HCT-116	M4HORmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYXJR\|UxRTFwNEK4OVQh\|ryP	Mn32V2FPT0WU
ALL-PO	NHvIW5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1XKZ2lEPTB;MT60N\|c4PCEQvF2=	NITWSXJUSU6JRWK=
EW-16	MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml\5TWM2OD1zLkSzPFQzKM7:TR?=	M4\V[XNCVkeHUh?=
NCI-H661	M{n6fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGDKfmRKSzVyPUGuOFQ4PzVizszN	M3Tw[HNCVkeHUh?=
TE-8	NFewT3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEjPNGNKSzVyPUGuOFU2PiEQvF2=	MnP6V2FPT0WU
TCCSUP	M1TneGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXnJR\|UxRTFwNE[5OkDPxE1?	MUnTRW5ITVJ?
SW1990	NF3T[HpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVW2NnVjUUN3ME2xMlQ4PTN\|IN88US=>	MXfTRW5ITVJ?
UM-UC-3	NFzn[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4PodWlEPTB;MT60O\|Y4PSEQvF2=	MUnTRW5ITVJ?
HuP-T4	Mon1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2OwXGlEPTB;MT60PFYxPyEQvF2=	NY\zTYpZW0GQR1XS
NCI-H1299	MnriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFPhb4tKSzVyPUGuOVAxQDZizszN	NX;sb3p5W0GQR1XS
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Becker	MmrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4rLemlEPTB;MT61NlE5PyEQvF2=	NWHtb49iW0GQR1XS
SNU-387	NGLTVmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1rwTGlEPTB;MT61NlI1OSEQvF2=	NELGRmFUSU6JRWK=
CAL-85-1	NEnLeVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV\JR\|UxRTFwNUK1PVkh\|ryP	NFuxeWpUSU6JRWK=
647-V	Mk\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFjMd3NKSzVyPUGuOVM5QCEQvF2=	NH7QUG1USU6JRWK=
SBC-5	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmH0TWM2OD1zLkW0OVk{KM7:TR?=	MlXDV2FPT0WU
NCI-H23	MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVHJR\|UxRTFwNUW3NVQh\|ryP	MmHHV2FPT0WU
CGTH-W-1	NYfjXJY{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXvJR\|UxRTFwNUW4NVkh\|ryP	MVnTRW5ITVJ?
SK-N-FI	NEDpZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV7JR\|UxRTFwNUW5NFgh\|ryP	NX;DRlVZW0GQR1XS
KM-H2	M3L0UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFzhOWxKSzVyPUGuOVY1PzRizszN	MnvDV2FPT0WU
KY821	NFLUc5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MX3JR\|UxRTFwNU[2NVch\|ryP	NH74WXNUSU6JRWK=
RH-1	NFPIUWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVvJR\|UxRTFwNU[3OlIh\|ryP	MWHTRW5ITVJ?
KYSE-270	NFHSUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXHJR\|UxRTFwNUe0NlMh\|ryP	M3Pk[HNCVkeHUh?=
SF539	M1PuRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2\jUmlEPTB;MT61O\|k3QSEQvF2=	NHHGWm9USU6JRWK=
JEG-3	M3OyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MY\JR\|UxRTFwNUiwPVQh\|ryP	NVSxfWFEW0GQR1XS
SCC-25	M1f6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHTTOVRKSzVyPUGuOVg1OzJizszN	NFqyfYVUSU6JRWK=
SW1573	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWD6T5Y2UUN3ME2xMlYxOTV6IN88US=>	M2XLNXNCVkeHUh?=
EW-1	M1yxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4TXSmlEPTB;MT62NVM2OSEQvF2=	MYPTRW5ITVJ?
YKG-1	NVvWVoxyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkHITWM2OD1zLk[xOFM5KM7:TR?=	MV;TRW5ITVJ?
EW-11	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVTJR\|UxRTFwNkG3OFEh\|ryP	MnfWV2FPT0WU
DJM-1	NGnLTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGPoNopKSzVyPUGuOlE5OjVizszN	NVnKNHVqW0GQR1XS
Calu-3	MmjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVnJR\|UxRTFwNkWyNVMh\|ryP	M3rTTXNCVkeHUh?=
HT-3	M4rHO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4DRcGlEPTB;MT62OVY3KM7:TR?=	NG[wdFlUSU6JRWK=
NCI-H69	NVPFcIczT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlPtTWM2OD1zLk[3N\|Q{KM7:TR?=	NYLBXlRyW0GQR1XS
NCI-H2126	NIHrNmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoTBTWM2OD1zLk[3O\|k4KM7:TR?=	MoG0V2FPT0WU
RPMI-2650	M1:xSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWTJR\|UxRTFwNkizNVch\|ryP	NGjhbZJUSU6JRWK=
TE-6	MkXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXvNNY9IUUN3ME2xMlcxQDd2IN88US=>	MnL5V2FPT0WU
MDA-MB-231	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoD3TWM2OD1zLkexPVk{KM7:TR?=	Mn7sV2FPT0WU
A2780	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1vvZmlEPTB;MT63NlIxPyEQvF2=	M2TZfHNCVkeHUh?=
GOTO	NHXkeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGTuXo1KSzVyPUGuO\|M2PiEQvF2=	MonrV2FPT0WU
KYSE-70	M{TGVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4m0fWlEPTB;MT63OFQ1OiEQvF2=	NF;mN3NUSU6JRWK=
GMS-10	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX7JR\|UxRTFwN{S2OlIh\|ryP	NGe5VphUSU6JRWK=
CaR-1	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYfJR\|UxRTFwN{S4NVIh\|ryP	M13QZnNCVkeHUh?=
SW900	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFPjdZpKSzVyPUGuO\|Q6QTNizszN	NYnnNZFJW0GQR1XS
BB49-HNC	NYLGXGNyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFi5OlBKSzVyPUGuO\|UyPjhizszN	MX;TRW5ITVJ?
SNB75	NITZdJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn\rTWM2OD1zLke1OFkzKM7:TR?=	MVTTRW5ITVJ?
SK-PN-DW	NWnoRZo2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXHJR\|UxRTFwN{W2PFIh\|ryP	NGDWTo9USU6JRWK=
5637	NIXBe3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXjJR\|UxRTFwN{eyOlgh\|ryP	M{HRO3NCVkeHUh?=
BT-474	NVrudIdIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWPJR\|UxRTFwN{ixO\|Eh\|ryP	M2LGfHNCVkeHUh?=
KM12	M1PaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4P4cGlEPTB;MT63PVc1OSEQvF2=	NUK4N3FpW0GQR1XS
COLO-680N	NF\vRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVXx[m85UUN3ME2xMlgzOzhzIN88US=>	M1S2NnNCVkeHUh?=
Saos-2	MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH\iXZBKSzVyPUGuPFI1PDVizszN	M{LTeXNCVkeHUh?=
CAL-54	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGTKRYlKSzVyPUGuPFM{OTNizszN	NWfSdJp1W0GQR1XS
U-118-MG	M2e4fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTFwOES2NlIh\|ryP	MkXsV2FPT0WU
TGBC24TKB	M2POZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnPyTWM2OD1zLki1OVAyKM7:TR?=	NVvRSYNvW0GQR1XS
NCI-H2052	NUK1d3BDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXn0XGNOUUN3ME2xMlg3PDFizszN	NF31eIRUSU6JRWK=
BB30-HNC	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGPzbpBKSzVyPUGuPFY1PjJizszN	MXXTRW5ITVJ?
KNS-81-FD	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVPaPXY{UUN3ME2xMlg6OTZ3IN88US=>	M{DVRnNCVkeHUh?=
HN	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{T0VWlEPTB;MT64PVU1PSEQvF2=	NVz6U4JNW0GQR1XS
ACHN	Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXzJR\|UxRTFwOUC3PFYh\|ryP	MV7TRW5ITVJ?
HSC-2	MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXXmbW1lUUN3ME2xMlkyODl4IN88US=>	M4ezW3NCVkeHUh?=
HCC2998	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmL0TWM2OD1zLkmzN\|I2KM7:TR?=	NVjwbJVVW0GQR1XS
HEL	NIjPUm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4frdGlEPTB;MT65OFE5PCEQvF2=	NYn4TFJzW0GQR1XS
SW684	M{flbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVPJR\|UxRTFwOUezO\|Eh\|ryP	NEXF[YNUSU6JRWK=
NCI-H1693	NWS2VFNiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVXROop3UUN3ME2xMlk5ODh4IN88US=>	NHz5eYNUSU6JRWK=
8-MG-BA	NVXlVlFPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYnJR\|UxRTFwOUiyNUDPxE1?	NXzUdndsW0GQR1XS
OVCAR-8	Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIX5VI5KSzVyPUKuNFAzQTVizszN	NXfuZ5V7W0GQR1XS
DSH1	M4ezbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkjDTWM2OD1{LkCxO\|c1KM7:TR?=	MYDTRW5ITVJ?
KYSE-520	NHPuW4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXLrcIJ[UUN3ME2yMlAzODR7IN88US=>	NVvpR3JCW0GQR1XS
GB-1	M3;xXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1nBWWlEPTB;Mj6wNlU4PyEQvF2=	Ml6zV2FPT0WU
RCC10RGB	NFXSWYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4PJemlEPTB;Mj6wOFg4OSEQvF2=	MVjTRW5ITVJ?
SW954	M3zQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVHJR\|UxRTJwMEWwN\|Yh\|ryP	MYjTRW5ITVJ?
IST-MES1	NF;XRlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGqxc3ZKSzVyPUKuNFU2PjhizszN	MUHTRW5ITVJ?
AU565	M3;NOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIjwUW9KSzVyPUKuNFU6ODVizszN	M{PZRnNCVkeHUh?=
CW-2	M2nxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWrJR\|UxRTJwME[4O\|Uh\|ryP	NWTUTWZuW0GQR1XS
TE-1	MnzFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYLJR\|UxRTJwMEmzO\|ch\|ryP	NUPIbI1CW0GQR1XS
KP-4	NFK4e3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnrjTWM2OD1{LkGwN\|EzKM7:TR?=	MkjDV2FPT0WU
SNU-C2B	NV;t[45lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVfhcFU3UUN3ME2yMlExQDJ\|IN88US=>	NGnWRm9USU6JRWK=
NCI-H1395	MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3zQ[WlEPTB;Mj6xNFk5PiEQvF2=	M3jR[3NCVkeHUh?=
CAS-1	MofCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUDJR\|UxRTJwMUG1OFYh\|ryP	M2TrcXNCVkeHUh?=
NCI-H1155	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXfqWWJUUUN3ME2yMlIzPjlizszN	M2nvSHNCVkeHUh?=
SK-MEL-1	M1r3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEfPPFJKSzVyPUKuNlgyQDFizszN	MlLtV2FPT0WU
KINGS-1	NUHy[oc2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml3qTWM2OD1{LkOwNFg5KM7:TR?=	MXTTRW5ITVJ?
ESS-1	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF30eI5KSzVyPUKuN\|A2OSEQvF2=	NGOzdm1USU6JRWK=
PANC-10-05	NEH3S5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVnJR\|UxRTJwM{ewNlQh\|ryP	NG[4N25USU6JRWK=
HT-1376	NWH3WppLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHPWXGNKSzVyPUKuN\|g4ODhizszN	MXjTRW5ITVJ?
LS-513	NV\T[3VZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnjPTWM2OD1{LkO4PFc1KM7:TR?=	MkTzV2FPT0WU
KNS-42	M37zS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH30XXlKSzVyPUKuN\|kyODVizszN	Ml7kV2FPT0WU
639-V	MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1nJemlEPTB;Mj60Nlc2QCEQvF2=	NHzjc4tUSU6JRWK=
SJRH30	M1\6eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{T0[GlEPTB;Mj60OVE3OSEQvF2=	MXHTRW5ITVJ?
SW1783	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NY\0R29mUUN3ME2yMlQ4ODd6IN88US=>	M176dnNCVkeHUh?=
NB6	M3y4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2rnXmlEPTB;Mj60PFI5KM7:TR?=	NUnneYFFW0GQR1XS
SK-MEL-30	NXu0W3ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVXjXHNlUUN3ME2yMlQ5QDNizszN	MmO0V2FPT0WU
HCE-4	NF;QUZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWPTeoozUUN3ME2yMlQ6PDB{IN88US=>	MWnTRW5ITVJ?
NB10	M33WVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkG4TWM2OD1{LkS5OFI6KM7:TR?=	M33Q[XNCVkeHUh?=
H-EMC-SS	MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHXZZ5RKSzVyPUKuOVQ3PSEQvF2=	MmXjV2FPT0WU
SK-HEP-1	NEThZWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{XZNWlEPTB;Mj61OVI{PiEQvF2=	NEWzV25USU6JRWK=
HCC1395	M4Dp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXnXcpB7UUN3ME2yMlU2PjV3IN88US=>	M{jUbXNCVkeHUh?=
HuCCT1	MljxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFjPe\|dKSzVyPUKuOVY{QSEQvF2=	NIm2cFdUSU6JRWK=
SiHa	NEfaV3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1\0[2lEPTB;Mj61PFcyQSEQvF2=	NG\LRnZUSU6JRWK=
EFO-21	NWrkOWlLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3nLO2lEPTB;Mj61PFc3PCEQvF2=	NX7xUlRHW0GQR1XS
NCI-H1666	NUXUVph2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn;DTWM2OD1{LkW5NFc3KM7:TR?=	NGW3OXhUSU6JRWK=
UMC-11	NGW0WFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M32ycmlEPTB;Mj61PVg3QCEQvF2=	NGO1RmVUSU6JRWK=
COLO-679	M1LrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmDWTWM2OD1{Lk[xNlM{KM7:TR?=	Mn3pV2FPT0WU
A388	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWqyPZRwUUN3ME2yMlY2OjV\|IN88US=>	M1LnRXNCVkeHUh?=
LB2518-MEL	M3jaT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnvFTWM2OD1{Lk[1OFA5KM7:TR?=	NFraO29USU6JRWK=
EW-13	M1P4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVjJR\|UxRTJwNki3Olgh\|ryP	Mlj3V2FPT0WU
MLMA	NXH4VWg6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{TWPWlEPTB;Mj62PFg2PiEQvF2=	NEPkUGxUSU6JRWK=
HOP-92	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXLXSZBrUUN3ME2yMlcxOTFizszN	MoG2V2FPT0WU
NOMO-1	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWTuWI5TUUN3ME2yMlcyPDR{IN88US=>	NYXDWZZ1W0GQR1XS
NCI-H810	NXfSd\|J{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEXzdmNKSzVyPUKuO\|IyQThizszN	MlHVV2FPT0WU
769-P	NI\qd4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHXs[2JKSzVyPUKuO\|IzQCEQvF2=	MVLTRW5ITVJ?
SAS	NHrieppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3G2N2lEPTB;Mj63OlUh\|ryP	NHK3WYRUSU6JRWK=
M059J	NU[5O3RtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUXMRW53UUN3ME2yMlc5OzF6IN88US=>	NGPuVWtUSU6JRWK=
RD	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEnUe3JKSzVyPUKuO\|k1PzFizszN	NYDHcnNLW0GQR1XS
GT3TKB	MnraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVLNd3p[UUN3ME2yMlg{PDN\|IN88US=>	NYHD[GtpW0GQR1XS
MZ7-mel	MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1\0VGlEPTB;Mj64OlUxOiEQvF2=	NIXKe\|RUSU6JRWK=
KYSE-510	M36w[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mlj2TWM2OD1{Lki5OVA1KM7:TR?=	M4W5UHNCVkeHUh?=
NCI-N87	M17KN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2rnS2lEPTB;Mj65NVgxPyEQvF2=	MVTTRW5ITVJ?
MKN1	NFzvXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mm[1TWM2OD1\|LkCwNVY{KM7:TR?=	MXzTRW5ITVJ?
NCI-H2170	NVO4V\|JST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF\1RXpKSzVyPUOuNFA1PTFizszN	NYL0WJZNW0GQR1XS
OVCAR-3	NUPqbpZWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGqwdohKSzVyPUOuNFIyOTVizszN	NFLMXHZUSU6JRWK=
KLE	NX7DdY9kT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{\CemlEPTB;Mz6wOlgyOiEQvF2=	MnHIV2FPT0WU
LB771-HNC	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIPyTpRKSzVyPUOuNFk{PDNizszN	NXTJNXpZW0GQR1XS
MC116	M{fX[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXXJR\|UxRTNwMUGxNVIh\|ryP	Mn36V2FPT0WU
SCC-9	NF;IWlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MknHTWM2OD1\|LkGxN\|Y3KM7:TR?=	NVOybVdHW0GQR1XS
U031	NGjvVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIK2b5hKSzVyPUOuNVI1OjNizszN	M{DJXXNCVkeHUh?=
LCLC-103H	M1rJfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIjp[3RKSzVyPUOuNlM5QTRizszN	MVjTRW5ITVJ?
U-266	M{i1eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4XBbmlEPTB;Mz6yO\|Y{OyEQvF2=	NUDsTnZbW0GQR1XS
JVM-2	M4TjXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NELMW5dKSzVyPUOuN\|IyPjRizszN	MXnTRW5ITVJ?
UACC-257	M3PMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlzLTWM2OD1\|LkS2OFMyKM7:TR?=	NHXnb3ZUSU6JRWK=
LB996-RCC	NV;FbY5[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mmq5TWM2OD1\|LkS2OVAzKM7:TR?=	NYruNodyW0GQR1XS
BT-549	MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFLxTI5KSzVyPUOuOVAzODlizszN	NGm1Z2ZUSU6JRWK=
NCI-H526	NYXNSVVkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4SyWGlEPTB;Mz61OFE2QCEQvF2=	M3TGS3NCVkeHUh?=
RH-18	NUPEdIlET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV;6eIF4UUN3ME2zMlYyPzl6IN88US=>	MXjTRW5ITVJ?
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IGR-1	NGLudoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXW4Z25nUUN3ME2zMlc1OjR6IN88US=>	MVvTRW5ITVJ?
NCI-H2291	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV7JR\|UxRTNwN{WzN\|Yh\|ryP	Mn;JV2FPT0WU
NCI-H441	NXP6U5ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1HJTWlEPTB;Mz64NlQ{OyEQvF2=	MX;TRW5ITVJ?
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COLO-320-HSR	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3PuOGlEPTB;Mz65NVI4OSEQvF2=	NIjBPGpUSU6JRWK=
A253	M2nN[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYjJR\|UxRTNwOUG0N\|Yh\|ryP	NYi1XldYW0GQR1XS
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RERF-LC-MS	NYTueWRKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFzXPJFKSzVyPUOuPVY2OjVizszN	MUjTRW5ITVJ?
SF268	NU\0VI5tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkLMTWM2OD12LkGyPFgyKM7:TR?=	M3HIN3NCVkeHUh?=
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CFPAC-1	M{\6NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2nYPWlEPTB;ND6yNVY5PSEQvF2=	MY\TRW5ITVJ?
S-117	M2\yPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml63TWM2OD12LkKyNFI1KM7:TR?=	NUjhVGRpW0GQR1XS
NCI-H2122	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIjuU2ZKSzVyPUSuN\|A6OzFizszN	MWrTRW5ITVJ?
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CAL-72	NVS2SIg4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlrtTWM2OD12LkO1OFc4KM7:TR?=	NHy4fpVUSU6JRWK=
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UACC-62	M37WcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MljoTWM2OD12LkS2OVQ2KM7:TR?=	NVTYU3pzW0GQR1XS
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RCM-1	NWfmRW8{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV[0VnNSUUN3ME20MlUzQTJizszN	NEPlXVBUSU6JRWK=
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SW756	NHnXd2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3LHVGlEPTB;ND62PVE{PSEQvF2=	M2XBXXNCVkeHUh?=
HCC38	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1vJe2lEPTB;ND63NVE6PyEQvF2=	MnXyV2FPT0WU
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OAW-28	Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{XoSGlEPTB;ND65NlQ{PSEQvF2=	NXrUR4VxW0GQR1XS
MEG-01	M2rpZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlvWTWM2OD13LkC4N\|I5KM7:TR?=	NHj2cIZUSU6JRWK=
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FADU	NUnJbHc3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn\KTWM2OD13LkK3PFM4KM7:TR?=	MmruV2FPT0WU
CAPAN-1	NHHzVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHnUOo5KSzVyPUWuN\|k1OzJizszN	NVHyUWJ3W0GQR1XS
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ONS-76	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXzGWJp[UUN3ME21MlU2QDBzIN88US=>	NVzTO\|l4W0GQR1XS
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COLO-741	NHL5SlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NX7ueYpuUUN3ME21MlcyQTl3IN88US=>	NIDR[pRUSU6JRWK=
HT-29	NVz6SmpqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYrJR\|UxRTVwOEC0O\|Uh\|ryP	M1fRcXNCVkeHUh?=
HCC1187	NUDtV3N7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWXJR\|UxRTVwOEGwNFgh\|ryP	MV;TRW5ITVJ?
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NCI-H630	NY\td5lET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2jsWGlEPTB;Nj6xNVQ1OSEQvF2=	MY\TRW5ITVJ?
COLO-678	NX7sOIpjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2D4[GlEPTB;Nj6xOVA6OiEQvF2=	MWPTRW5ITVJ?
D-502MG	MkfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYTJR\|UxRTZwMUezN\|Yh\|ryP	NIjMdXdUSU6JRWK=
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SK-MEL-24	Ml36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVPnZ2Y{UUN3ME22MlI3PDlizszN	MYnTRW5ITVJ?
NCI-SNU-5	MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4rTcGlEPTB;Nj6yO\|EyQCEQvF2=	MkXTV2FPT0WU
D-392MG	NWn1OHlET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWHJN5R2UUN3ME22MlM{Ozl7IN88US=>	NXXrem0zW0GQR1XS
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OCI-AML2	NH\POJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M371UGlEPTB;Nj60OVQ1PSEQvF2=	NYrJSlFGW0GQR1XS
HCC2157	NHjibWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlXuTWM2OD14LkS1OlE3KM7:TR?=	MnX2V2FPT0WU
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NCI-H1650	NInHU5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVPUTWl3UUN3ME22MlcxPTJ{IN88US=>	M3uyWHNCVkeHUh?=
DU-145	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVT6Z\|F5UUN3ME22Mlc4ODNizszN	M4rkRXNCVkeHUh?=
COLO-829	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MULJR\|UxRTZwN{e4O\|Mh\|ryP	NH\ObmNUSU6JRWK=
LS-1034	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEj0dlVKSzVyPUeuNFQ1OTJizszN	MmHqV2FPT0WU
HCC1954	M3\jR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHfGUGxKSzVyPUeuOFgyOzRizszN	NUDvfpdYW0GQR1XS
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Mo-T	Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MojpTWM2OD15LkWxOFk5KM7:TR?=	MUnTRW5ITVJ?
OE19	M3XZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmKwTWM2OD15Lk[1OVA{KM7:TR?=	MnTCV2FPT0WU
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NCI-H2342	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3LHXWlEPTB;Nz63NVUzOSEQvF2=	M1XoVHNCVkeHUh?=
U-87-MG	M2XL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVLJR\|UxRThwMEOzN\|Qh\|ryP	MmLuV2FPT0WU
MKN28	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVfaSm8zUUN3ME24MlEyPTF3IN88US=>	NYXJUmZbW0GQR1XS
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ChaGo-K-1	MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGmwd2RKSzVyPUiuN\|QzPDVizszN	M1OwSHNCVkeHUh?=
NCI-H226	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV3JR\|UxRThwNESzN\|Eh\|ryP	MXLTRW5ITVJ?
NCI-H2029	Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2HPS2lEPTB;OT6wOlc2QSEQvF2=	Mlq4V2FPT0WU
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SW837	NIXBXnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2jscmlEPTB;MUCuNlI6OyEQvF2=	M{TMR3NCVkeHUh?=
NCI-H1651	Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUn2eZJ2UUN3ME2xNE4zOzJ4IN88US=>	M3X1dXNCVkeHUh?=
NCI-H727	MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFHKemZKSzVyPUGwMlQ1QTVizszN	MkDLV2FPT0WU
NCI-H358	M4r4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MULJR\|UxRTFyLkizOlUh\|ryP	MmTTV2FPT0WU
NCI-H2087	MnL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYrJR\|UxRTFzLkC0N\|Qh\|ryP	NH;wcVNUSU6JRWK=
FTC-133	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1PIXWlEPTB;MUGuOFA2OSEQvF2=	M3\sRXNCVkeHUh?=
LAN-6	NELLcYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmDETWM2OD1zMj6xNlQh\|ryP	M2L2TXNCVkeHUh?=
NCI-H1838	M3P2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEfmWJZKSzVyPUGyMlUyPTFizszN	NIHQNZdUSU6JRWK=
Calu-6	NYT3Z3JKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NG\IW5dKSzVyPUG0MlExOjFizszN	M4q5d3NCVkeHUh?=
HCC70	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV;XXYtIUUN3ME2xOE41PTFizszN	M1;OenNCVkeHUh?=
KARPAS-299	MnnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF3FT41KSzVyPUG1MlIyPTlizszN	MmPLV2FPT0WU
CAL-27	NVHhZ49[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MU\JR\|UxRTF3LkO4OFMh\|ryP	M2[4fHNCVkeHUh?=
NCI-H82	NYG4SYRJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGHiOmNKSzVyPUG1MlU{OiEQvF2=	NEL1OYZUSU6JRWK=
no-10	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2fTeWlEPTB;MUWuPVM5KM7:TR?=	MljVV2FPT0WU
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COLO-824	M2e2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWTJR\|UxRTJyLkmyO\|Yh\|ryP	NVL0XVB[W0GQR1XS
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ABC-1	NGHGW29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIrkVFRKSzVyPUK2Mlc6PTdizszN	MY\TRW5ITVJ?
MHH-NB-11	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkPpTWM2OD1\|Mz6zOFY1KM7:TR?=	MWDTRW5ITVJ?
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NB12	NFrCb2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWrJR\|UxRTN7LkS2OVUh\|ryP	NVfvUWVJW0GQR1XS
NY	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUnJR\|UxRTRzLkOyNFEh\|ryP	M1HER3NCVkeHUh?=
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H446	M2DHRWFxd3C2b4Ppd{BCe3OjeR?=	NX3vVoxSPTByIH7N	M4TaR\|czKGh?		M4LseY5p[W6lZYOgRWJVNTJ4M,MAl4lv\HWlZXSgZZBweHSxc3nz	MnnyNlU4Ozd3NEK=
TFK-1	M4Kxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MVe3NkBp	MXvEUXNQ	M1;tcGlEPTB;NEegcm0>	NVzjUnFDOjVzNUKyOFQ>
EGI-1	NHToNmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NF[xWGU4OiCq	NXLLdIJVTE2VTx?=	M4X6VGlEPTB;NUOgcm0>	NH7JXZQzPTF3MkK0OC=>
OCI/AML3	NWLZT5lrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2fnfVAvOiEQvF2=	MnnwOFghcA>?		MlGz[Y5p[W6lZYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCrbnT1Z4VlKGK7IIPlcJVu\XSrbnni	NELjeW4zPDd\|OUO5Ny=>
U937	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MkXaNE4zKM7:TR?=	M{nqZ\|Q5KGh?		MmPP[Y5p[W6lZYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCrbnT1Z4VlKGK7IIPlcJVu\XSrbnni	MnyyNlQ4Ozl\|OUO=
MOLM13	M{TwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIPlU2UxNjJizszN	MV60PEBp		M1faPYVvcGGwY3XzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iaX7keYNm\CCkeTDz[Yx2dWW2aX7pZi=>	NX3kfGc3OjR5M{mzPVM>
MCF7	NWLpboZjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MWiyNEBvVQ>?	NE[0Slg4OiCq	MUfGRnM>	NIfXVFRz\WS3Y3XzJJRp\SCSRVzQNU1u\WSrYYTl[EBqdmO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fS=>	MXGyOFY5QDB2Nh?=
TamR	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4nCZ2lEPTB;MUlihKlvVQ>?	NVfE[3dyOjR2NUewOlk>
MCF7-X	NH;1[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4\rUmlEPTB;MkSgcm0>	MXuyOFQ2PzB4OR?=
T47D-tamR	NYPQRVBrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3rMRmlEPTB;MUmgcm0>	NYjzW3BIOjR2NUewOlk>
293T	MXjGeY5kfGmxbjDBd5NigQ>?	NVnne486OjBibl2=	NE\MNZo{KGh?		NFvEcJhlcXO{dYD0d{BCc3RvbXXkbYF1\WRiVFnGMWlCKHO2YXLpcIl1gSxidILhcpNtd2OjdHnvckwh[W6mIHHjeIl3cXS7	MlLRNlQ{PjN2NEm=
SW620	M{CyW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIrEUoIxNjByMT2xNO69VQ>?	MoD1NlQhcA>?		M{\FN4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iYYOgeIhmKGOxbnPlcpRz[XSrb36gdol{\XN?	M1\0WFI1OzZ\|NES5
Huh7	MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NFH2[JA2NTFyMDDuUS=>	M1HabVAuOjRiaB?=	NUPJPGVGTE2VTx?=	MX7pcoNz\WG\|ZYOgZ4VtdCCmZXH0bEBqdiCjIHPvcoNmdnS{YYTpc44uKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI>	Mo\wNlQzQTd\|MEC=
Hep3B	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NUe3Z4ZPPS1zMECgcm0>	NHqxN3AxNTJ2IHi=	M{X0WmROW09?	MYjpcoNz\WG\|ZYOgZ4VtdCCmZXH0bEBqdiCjIHPvcoNmdnS{YYTpc44uKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI>	NVXyflNDOjR{OUezNFA>
Huh7	MlnKSpVv[3Srb36gRZN{[Xl?	M{jkeFExOCCwTR?=	MVmxNkBp	NEjDfGpFVVOR	MmHZbY5lfWOnczDheZRweGijZ4pCpC=>	MoX3NlQzQTd\|MEC=
U87-MG	NX\6WGZMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NHvJSJQ4OiCq		MX7HTVUx6oDLPfMAjVc6KG6PwrC=	M4rHSlI1OjR7NkSw
L3.6pl	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MX[xJO69VQ>?	MljsO\|IhcA>?		MkfQbY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHPvcYJqdmWmIIfpeIghSk2VLUe3O\|YxPw>?	NXvJfpFHOjR{M{OzPVk>
TE671	NILyU4VCeG:ydH;zbZMhSXO\|YYm=	NGnIPWEyKM7:TR?=	NFqyPI41QCCq		M3[ybolv[3KnYYPld{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JGFDXC15M{e=	MnXJNlQyOzN{MUi=
RD	M{WyeWFxd3C2b4Ppd{BCe3OjeR?=	MmPLNUDPxE1?	NV;NXGxJPDhiaB?=		NXyyelJjcW6lcnXhd4V{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhSUKWLUezOy=>	MUSyOFE{OzJzOB?=
RMS13	Ml\MRZBweHSxc3nzJGF{e2G7	NVPLWWxwOSEQvF2=	MU[0PEBp		NV;0T5ZucW6lcnXhd4V{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhSUKWLUezOy=>	NX33WGtLOjRzM{OyNVg>
RH30	M2G2fGFxd3C2b4Ppd{BCe3OjeR?=	MYexJO69VQ>?	NH;BWVA1QCCq		NFLrPG9qdmO{ZXHz[ZMh[2WubDDhdI9xfG:\|aYOgbY5lfWOnZDDifUBCSlRvN{O3	MYKyOFE{OzJzOB?=
Hep-2	NGfn[WNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF3MeZkxNjBzLUGg{txO	M13tXlEzNTl4IHi=		Mlu0bY5kemWjc3XzJINmdGxiZHXheIghcW5iYTDjc45k\W62cnH0bY9vNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVz	M3:4UFI1OTB\|N{S5
SCC-9	NYDBXnQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MnXONE4xOS1zIN88US=>	M4XZWFEzNTl4IHi=		NYPqUWt{cW6lcnXhd4V{KGOnbHyg[IVifGhiaX6gZUBkd26lZX70doF1cW:wLTDhcoQhfGmvZT3k[ZBmdmSnboSgcYFvdmW{	M{fWb\|I1OTB\|N{S5
Hep-2	NUfrdYtZTnWwY4Tpc44hSXO\|YYm=	MljtNE4yNzBwNTFOwG0>	NF7RZYUzPCCq		MYXicI9kc3NibWTPVmMyKGGwZDDtWG9TSzJiYXP0bZZifGmxbh?=	NFrveXQzPDFyM{e0PS=>
SCC-9	MoqwSpVv[3Srb36gRZN{[Xl?	MWewMlEwOC53IN88US=>	NYqwPFdlOjRiaB?=		NXK0U4I2[myxY3vzJI1VV1KFMTDhcoQhdVSRUlOyJIFkfGm4YYTpc44>	MnLnNlQyODN5NEm=
PANC-1	M1fqXGFxd3C2b4Ppd{BCe3OjeR?=	M4fKXlUxOCCwTR?=	NIjSe481QCCq		NHT1bW9{\W6\|aYTpfoV{KHCjbnPy[YF1cWNiY3HuZ4VzKGOnbHzzJJRwKHKjZHnveIhmemGyeR?=	MkH5NlM5QDZ{OUS=
RMG2	M1TCbGFxd3C2b4Ppd{BCe3OjeR?=	M4XEUVEuOTByMDDuUS=>	M2L4OFczKGh?	MYjGRnM>	NEPpTWhqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkh[2:wY3XueJJifGmxbjDk[ZBmdmSnboTsfS=>	NVH1XYpwOjN4MUW2N\|E>
HAC2	NFXyNoNCeG:ydH;zbZMhSXO\|YYm=	Ml[5NU0yODByIH7N	M1jS[VczKGh?	MoPZSmJU	NGXSd4lqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkh[2:wY3XueJJifGmxbjDk[ZBmdmSnboTsfS=>	NGjyWpYzOzZzNU[zNS=>
HT-29	NXzMfppMSXCxcITvd4l{KEG\|c3H5	M2fXdlEh\|ryP	MVO3NkBp		M3XqR4F1fGWwdXH0[ZMhPS2IVT3pcoR2[2WmIHPlcIwh\GWjdHi=	M2PiRVIyQTR7MUKx
DLD1	MkDuRZBweHSxc3nzJGF{e2G7	Mn\zNUDPxE1?	MkfRO\|IhcA>?		MlzVZZR1\W63YYTld{A2NU[XLXnu[JVk\WRiY3XscEBl\WG2aB?=	M2m3eFIyQTR7MUKx
HT-29	NYj1Z2g3TnWwY4Tpc44hSXO\|YYm=	MVexJO69VQ>?	NVXkbGNUPzJiaB?=		M1rQdolv\HWlZYOgZZV1d3CqYXf5JJRwKGOxbn\ldkBkgXSxcILveIVkfGmxbh?=	NXv2UmtSOjF7NEmxNlE>
DLD1	NETpZ2dHfW6ldHnvckBCe3OjeR?=	MWWxJO69VQ>?	NID6[lc4OiCq		M3zVU4lv\HWlZYOgZZV1d3CqYXf5JJRwKGOxbn\ldkBkgXSxcILveIVkfGmxbh?=	M{j2N\|IyQTR7MUKx
Rh41	NWfpVoRpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2LSbmlEPTB;M{CuO{BvVQ>?	M2XTcVIyOzN5Nke5
Rh18	MojvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmTpTWM2OD12MT60JI5O	NVvMPJJTOjF\|M{e2O\|k>
Rh30	NWrMcW14T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYrOS3RGUUN3ME2xOEBvVQ>?	M2\OeVIyOzN5Nke5
BT-12	M4XpbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4rqRmlEPTB;MkSuO{BvVQ>?	NE\ybW4zOTN\|N{[3PS=>
CHLA-266	M3n1bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTFwMTDuUS=>	M2CyWlIyOzN5Nke5
TC-71	Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoXKTWM2OD12Nj61JI5O	NHfYVXIzOTN\|N{[3PS=>
CHLA-9	NEnLW3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVjJR\|UxRTF3LkOgcm0>	MmmwNlE{Ozd4N{m=
CHLA-10	NUXieYZzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVTPcJhsUUN3ME2zMlkhdk1?	NYeyb5RpOjF\|M{e2O\|k>
CHLA-258	NUL0R2lrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{X1e2lEPTB;MUCuOEBvVQ>?	NEK5fIEzOTN\|N{[3PS=>
GBM2	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoqwTWM2OD12MD63JI5O	NIWxSYUzOTN\|N{[3PS=>
NB-1643	MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3zmd2lEPTB;M{OuPEBvVQ>?	NHHGO\|QzOTN\|N{[3PS=>
NB-EBc1	MlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NI\IN3dKSzVyPUK3MlEhdk1?	MkPZNlE{Ozd4N{m=
CHLA-90	NXrUOGZlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXfkNIV6UUN3ME2zOE42KG6P	Mo\WNlE{Ozd4N{m=
CHLA-136	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml7GTWM2OD1zNkKuOkBvVQ>?	NHjteIszOTN\|N{[3PS=>
NALM-6	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFW5PHVKSzVyPUOyMlkhdk1?	MorPNlE{Ozd4N{m=
COG-LL-317	NWLtUY1{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MorRTWM2OD1zLkOgcm0>	MlPxNlE{Ozd4N{m=
RS4;11	NX3qd\|c4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmC5TWM2OD1\|NTDuUS=>	NYDKeZFGOjF\|M{e2O\|k>
MOLT-4	MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYDjSXRWUUN3ME24MlYhdk1?	M13oe\|IyOzN5Nke5
CCRF-CEM	M4XPcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2XWTWlEPTB;ND6xJI5O	M4rOXVIyOzN5Nke5
Kasumi-1	NIfqVJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkX3TWM2OD1zLkSgcm0>	M{PaPVIyOzN5Nke5
Karpas-299	MojJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4nodmlEPTB;MkGuO{BvVQ>?	NX3ZV5hHOjF\|M{e2O\|k>
Ramos-RA1	MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmHzTWM2OD16LkKgcm0>	NYfhXWhNOjF\|M{e2O\|k>
H838	MX;GeY5kfGmxbjDBd5NigQ>?	M{DLSlEh\|ryP	NEWyfo41QCCq		NVjjN\|Z2cW6mdXPld{Bk\WyuIHH1eI9xcGGpeR?=	MV[yNFM3PDFzMx?=
H838	M1n3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NWDpcHhKOC1\|IN88US=>	NVf3XHVzPzJiaB?=		NGK5TZZqdmS3Y3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CCjdYTvdIhi\3l?	MX[yNFAzQDh3NB?=
A549	M3;YT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MlLiNE0{KM7:TR?=	M1mzUlczKGh?		NF;IS5JqdmS3Y3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CCjdYTvdIhi\3l?	NFP4TZEzODB{OEi1OC=>

... Click to View More Cell Line Experimental Data

In vivo

AZD8055 inhibits the pS6 and pAkt in U87MG and A549 xenografts at 2.5/10 mg/kg, which leads to tumor growth inhibition. AZD8055 shows significant antitumor activity in many xenografts, including U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA at a dose of 10/20 mg/kg. ^[1] AZD8055 induces ~40% reduction in tumour volume, accompanied by ablation of phosphorylation of Akt, S6K and SGK protein kinases. Administration of AZD8055 (5mg/kg, Bid) and SAHA (100 mg/kg/d) results in complete tumor growth inhibition in PTEN+/−LKB1+/hypo xenografts without side effects on mice by inhibition of mTORC1 and mTORC2 signaling. ^[4]

Protocol

Kinase Assay:^[1]	+ Expand Cell-based determinations of mTOR inhibition: A high-throughput screening cell-based assay is developed using MDA-MB-468 cells to detect mTORC1 and mTORC2 activity. Cells are exposed for 2 hours to increasing concentrations of AZD8055. At the end of the incubation period, cells are fixed, washed, and probed with antibodies against S473 pAkt or against S235/236 phosphorylated S6 (pS6). Levels of phosphorylation are assessed using an Acumen laser scanning cytometer.
Cell Research:^[1]	+ Expand Cell lines: U87MG, A549 and H838 cells Concentrations: 1 nM - 1 μM Incubation Time: 72 to 96 hours Method: Cells are exposed to AZD8055 for 72 to 96 hours and stained for cell nuclei (0.03 mg/mL Hoechst 33342) and acidic vesicles (1 μg/mL acridine orange). Images are captured at 450 and 536 nm on an ArrayScan II platform, and the percentage of acidic vesicles and the number of cells are quantified. For LC3 assessment, cells are exposed to e64d/pepstatin (10 μg/mL) for 30 to 90 min before incubation with AZD8055. Cells are lysed on ice and analyzed by immunoblotting. (Only for Reference)
Animal Research:^[1]	+ Expand Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG and A549 are established in pathogen-free, female nude mice (nu/nu:Alpk). Formulation: Dissolved in captisol (CyDex, pH 3.0) and diluted to a final captisol concentration of 30% (w/v) Dosages: 2.5-20 mg/kg Administration: Oral gavage once or twice daily (Only for Reference)

References

[4] García-Martínez JM, et al. Br J Cancer, 2011, 104(7), 1116-1

+ Expand

Solubility (25°C)

In vitro	DMSO	50 mg/mL warmed (107.4 mM)
	Ethanol	3 mg/mL (6.44 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 4% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download AZD8055 SDF

Molecular Weight	465.54
Formula	C₂₅H₃₁N₅O₄
CAS No.	1009298-09-2
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-10-19)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01316809	Completed	Glioblastoma Multiforme\|Anaplastic Astrocytoma\|Anaplastic Oligodendroglioma\|Malignant Glioma\|Brainstem Glioma	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	March 4 2011	Phase 1
NCT00973076	Completed	Cancer\|Solid Tumors\|Advanced Solid Malignancies	AstraZeneca	August 2009	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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mTOR Signaling Pathway Map

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AZD8055

Cited by 38 Publications

8 Customer Reviews

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References

Solubility (25°C)

Chemical Information Download AZD8055 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

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Molecular Weight Calculator

Total Molecular Weight: g/mol

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-10-19)

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mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

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AZD8055

Cited by 38 Publications

8 Customer Reviews

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download AZD8055 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-10-19)

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mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

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Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)