AZD8055

Catalog No.S1555

Molecular Weight(MW): 465.54

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

Cited by 38 Publications

Nat Med, 2015, 10.1038/nm.3855

PubMed: 25939062

Cancer Cell, 2015, 27(1):97-108

PubMed: 25544637

Cancer Cell, 2015, 27(4):533-46

PubMed: 25873175

J Clin Invest, 2014, 10.1172/JCI73935

PubMed: 25415435

Genome Biol, 2016, 17(1):149

PubMed: 27380875

Nat Commun, 2014, 5:3384

PubMed: 24594970

Autophagy, 2012, 9(1):74-92

PubMed: 23196898

Cancer Res, 2014, 74(10):2846-56

PubMed: 24614082

Cancer Res, 2014, 74(14):3947-58

PubMed: 24986516

Cancer Res, 2013, 73(11):3402-11

PubMed: 23585456

Cell Rep, 2015, 11(3):446-59

PubMed: 25865887

Int J Cancer, 2014, 10.1002/ijc.28880

PubMed: 24706460
Antioxid Redox Sign, 2014, 20(9):1382-95

PubMed: 24063548

Am J Transplant, 2013, 13(8):2035-43

PubMed: 23841834

Mol Cancer Ther, 2013, 13(1):37-48

PubMed: 24233399

Cell Commun Signal, 2017, 10.1186/s12964-017-0164-3

PubMed: 28143584

Mol Oncol, 2013, 33:404-18

PubMed: 24444656

Mol Cell Proteomics, 2014, 13(6):1429-38

PubMed: 24643969

Clin Sci, 2015, 128(8):517-26

PubMed:

Mol Cancer Res, 2015, 13(2):223-30

PubMed:

Mol Cancer Res, 2015, 13(1):120-9

PubMed:

Exp Neurol, 2012, 233(2):799-806

PubMed: 22177999

Biochem Pharmacol, 2012, 83(9):1183-94

PubMed: 22305748

J Biol Chem, 2015, 10.1074/jbc.C114.627778

PubMed: 25833948
J Biol Chem, 2013, 288(49):35287-96

PubMed: 24133218

Am J Cancer Res, 2014, 4(6):824-837

PubMed:

Biochem J, 2015, 465(2):227-38

PubMed: 25353634

Mol Cell Biol, 2014, 34(13):2517-32

PubMed: 24777602

J Chromatogr A, 2015, 1388:267-73

PubMed:

Proteomics, 2015, 10.1002/pmic.201400586

PubMed: 25764225

Mol Biol Cell, 2013, 24(23):3736-45

PubMed: 24088573

Mol Reprod Dev, 2014, 81(7):655-65

PubMed: 24753052

PLoS One, 2016, 11(4):e0154564

PubMed: 27128484

PLoS One, 2013, 8(2):e56567

PubMed: 23451056

Biochem Biophys Res Commun, 2013, 440(4):701-6

PubMed: 24103749

Oncol Lett, 2013, 5(2):717-721

PubMed: 23420667
Oncotarget, 2014, 5(21):10732-44

PubMed: 25313141

Oncotarget, 2014, 5(15):6015-27

PubMed: 24970798

8 Customer Reviews

PC3-LN4 cells were treated with GSK690693 (5 uM) alone, or in combination with PP242 (2 uM) or AZD8055 (1 uM) for 24 h, and immunoblotting performed.

Cancer Res 2013 73(11), 3402-11. AZD8055 purchased from Selleck.

mTOR kinase inhibitor AZD8055 activates PI3K accompanied with induction of expression of EGFR, HER2, HER3 and IRS1. Serum-deprived CHO-EGFP-AKT cells were incubated with 50 nM AZD8055 for 24 hr. The EGFP signal was detected using confocal microscopy. The white arrows indicate EGFP-AKT located on cellular membrane.

Int J Cancer 2014 135(10), 2462-74. AZD8055 purchased from Selleck.
HUVEC were treated with either RAD001 or AZD8055 before PA treatment. p53, GPX1, p53 acetylation, and subcellular PTEN were analyzed with corresponding antibodies. The blot is a representative of the results of three experiments. Values (mean盨D) are expressed as fold over untreated control. *p<0.05 versus their corresponding control groups in the one-way ANOVA.

Antioxid Redox Signal 2014 20(9), 1382-95. AZD8055 purchased from Selleck.

CSCs^+24/44/ESA at 5,000 cells per well with stem cell culture media in triplicate in an ultra-low adhesion plate were treated with 5 umol/L BMS-777607, 1 umol/L AZD8055 alone, or in their different combinations. Cells were cultured for 72 hours. Cell viability was determined by the MTS assay. Percentages of polyploid cells were determined by counting 300 cells from two different regions. Results shown here were from one of two experiments with similar results.

Mol Cancer Ther 2014 13(1), 37-48. AZD8055 purchased from Selleck.
mTOR, P70S6K1, 4E-BP1 and PCNA activation in the basilar artery of SAH. Top, Western blotting bands of antibodies, bottom, density of the protein band from each group. A, mTOR activation in the basilar artery demonstrated an elevated expression of mTOR on day 7 following SAH in SAH and SAH+DMSO animals. The mTOR inhibitors, Rapamycin and AZD8055 reduced the enhanced expression of mTOR (pb0.05, ANOVA). B. P70S6K1 activation. C. 4E-BP1 activation. D. PCNA activation. Rapamycin and AZD8055 significantly decreased the expression of P70S6K1, 4E-BP1 and PCNA compared with the SAH and SAH+DMSO (pb0.05, respectively; ANOVA). There was no significant difference between the two inhibitors in mTOR, P70S6K1, 4E-BP1 and PCNA expression.

Exp Neurol 2012 233, 799-806. AZD8055 purchased from Selleck.

Induction of TCTP expression through 5-FU or oxaliplatin is inhibited by mTOR kinase inhibitors. HCT116 cells were treated for 48 h with 5-FU or oxaliplatin at the indicated concentrations. Where indicated, AZD 8055 (100 nM) or PP242 (1 μM) were added. TCTP levels were assessed by western blotting; signals were quantified and normalised against α-tubulin as a loading control. As a readout of mTOR activity, phosphorylation of the ribosomal protein S6 at Ser 240/244 was assessed using a phospho-specific antibody. a. Representative western blots demonstrating the alteration of the levels of TCTP protein and of phospho-ribosomal protein S6, respectively, in relation to the drug concentration.

Cell Commun Signal, 2017, 15(1):9. AZD8055 purchased from Selleck.
(A) HCT116 or MDA-MB-468 cells were treated with 500 nM AZD8055 for the indicated times. Cell lysates were immunoblotted with the indicated antibodies. (B) HCT116 or MDA-MB-468 cells were treated with 50 nM rapamycin. 500 nM AZD8055, 1 uM MK2206 or dimethyl sulfoxide (DMSO) as control for 12 h. Cell lysates were immunoblotted with the indicated antibodies.

Oncotarget 2014 5(15), 6015-27. AZD8055 purchased from Selleck.

After starved in serum-free medium for 24h , A549 cells incubated with the indicated concentrations of AZD8055 for 3h , followed by 20-minute stimolation of 100ng/ml EGF

Dr. Zhang of Tianjin Medical University. AZD8055 purchased from Selleck.

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

Features

First drug to inhibit both types of mTOR protein.

Targets

mTOR (truncated) ^[1] (MDA-MB-468 cells)	mTOR (full length) ^[1] (MDA-MB-468 cells)
0.13 nM	0.8 nM

In vitro

AZD8055 shows low activity (∼1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells. ^[1] AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. ^[2] AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7 nM and induces significant differences in EFS distribution. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
LU-139	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUTJR\|UxRTBwMEKzN\|Eh\|ryP	M3W2SnNCVkeHUh?=
NCI-H720	MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NInydYJKSzVyPUCuNFI6OzhizszN	MoC0V2FPT0WU
KARPAS-45	M4TVcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2\GNmlEPTB;MD6wN\|M4OSEQvF2=	MVfTRW5ITVJ?
EW-3	MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYjJR\|UxRTBwMESwOVYh\|ryP	MYfTRW5ITVJ?
SBC-1	MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHLwWWNKSzVyPUCuNFQ2QDFizszN	NET5eYpUSU6JRWK=
NCI-H209	NWXDU2NyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXO4N5huUUN3ME2wMlA2PDV\|IN88US=>	NGiwU4NUSU6JRWK=
EoL-1-cell	MkS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmriTWM2OD1yLkC2OVY6KM7:TR?=	MkX1V2FPT0WU
H9	NGXZXllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{HhR2lEPTB;MD6wOlY6OiEQvF2=	MYHTRW5ITVJ?
AN3-CA	MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXvOV3JTUUN3ME2wMlA4QTVzIN88US=>	NUPFO3RkW0GQR1XS
HH	M1nPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGn3eGJKSzVyPUCuNFgxODlizszN	M1PCVHNCVkeHUh?=
KU812	M2raNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWTv[WM6UUN3ME2wMlA5ODR\|IN88US=>	MVPTRW5ITVJ?
DU-4475	NF;CZ3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV7JR\|UxRTBwMEiwOFch\|ryP	M4n6T3NCVkeHUh?=
CTV-1	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFnEVXdKSzVyPUCuNFg3PDFizszN	MXXTRW5ITVJ?
BV-173	NGDmRWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1nEfWlEPTB;MD6wPVA3OSEQvF2=	MnznV2FPT0WU
ES5	M3O0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXrJR\|UxRTBwMEmzOUDPxE1?	MX;TRW5ITVJ?
G-402	M1X1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXf4S3EyUUN3ME2wMlA6QThizszN	Mn;EV2FPT0WU
MV-4-11	NYKye\|FQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXrJR\|UxRTBwMUCzOFch\|ryP	MkTDV2FPT0WU
NB69	NF;hT2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkHhTWM2OD1yLkGzOUDPxE1?	MVfTRW5ITVJ?
EGI-1	NWTmeXhUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkCxTWM2OD1yLkGzOVMyKM7:TR?=	M{\abnNCVkeHUh?=
EW-18	M3LsT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoL5TWM2OD1yLkG0NFc{KM7:TR?=	M2LRcXNCVkeHUh?=
ME-180	MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXL3V3J4UUN3ME2wMlE1PjhzIN88US=>	NYfIXW01W0GQR1XS
D-283MED	M2\BOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVXNVpNmUUN3ME2wMlE1PzJ\|IN88US=>	M13WRnNCVkeHUh?=
NB14	M{PK[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlrBTWM2OD1yLkG2OFQ4KM7:TR?=	NGPT[otUSU6JRWK=
Ramos-2G6-4C10	NYG5W3RrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUPJR\|UxRTBwMU[5PFMh\|ryP	NWfC[XNVW0GQR1XS
NBsusSR	NWO4co1LT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF:1OZZKSzVyPUCuNVcxOTlizszN	MVTTRW5ITVJ?
LAMA-84	NWLzb5JiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGPPO4hKSzVyPUCuNVgxOzJizszN	NGjDO2xUSU6JRWK=
NCI-H1581	NYrtOW5NT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlPsTWM2OD1yLkG4PVY3KM7:TR?=	NXjjRmRpW0GQR1XS
A204	MmjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVvJR\|UxRTBwMUi5O{DPxE1?	MX\TRW5ITVJ?
A549	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{fIW2lEPTB;MD6xPVU2KM7:TR?=	M3vDTXNCVkeHUh?=
CAL-51	NF\rZ3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVfJR\|UxRTBwMUm2OVEh\|ryP	MUfTRW5ITVJ?
NKM-1	NX33c45[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWPJR\|UxRTBwMkCwNlkh\|ryP	NUi3ZYdwW0GQR1XS
LoVo	NHXFU2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVvJR\|UxRTBwMkCyNFIh\|ryP	NFnYdI1USU6JRWK=
HAL-01	NGe0XGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVfJR\|UxRTBwMkCyPVch\|ryP	M1m2WHNCVkeHUh?=
HCC2218	MnS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnnwTWM2OD1yLkKwOlg5KM7:TR?=	MkDaV2FPT0WU
BEN	MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MULJR\|UxRTBwMkGyPVMh\|ryP	M4rUfnNCVkeHUh?=
LC-2-ad	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3:yXWlEPTB;MD6yNlA5PCEQvF2=	MV3TRW5ITVJ?
LXF-289	NWDVeYRpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2\6fGlEPTB;MD6yOVA1OSEQvF2=	NY\acZNrW0GQR1XS
HGC-27	NWTVbIpYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWTJR\|UxRTBwMk[0NVQh\|ryP	MV7TRW5ITVJ?
LK-2	Ml\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn21TWM2OD1yLkK2PFI1KM7:TR?=	MorOV2FPT0WU
CTB-1	M{frUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYf2PI9zUUN3ME2wMlI4OjF3IN88US=>	NEDHTJpUSU6JRWK=
697	NV3leZhCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mk\KTWM2OD1yLkK3N\|Y4KM7:TR?=	MYHTRW5ITVJ?
ES7	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYHJR\|UxRTBwMkezPFMh\|ryP	M{Xi[XNCVkeHUh?=
MG-63	NV7ZOpF3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXXJR\|UxRTBwMke0NFch\|ryP	MWjTRW5ITVJ?
T47D	MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmfuTWM2OD1yLkK3OFc2KM7:TR?=	MWjTRW5ITVJ?
RPMI-8226	NE\JVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVHJR\|UxRTBwMki1PFkh\|ryP	MYTTRW5ITVJ?
NCI-H292	MkjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHLiUo9KSzVyPUCuNlkyPjRizszN	MY\TRW5ITVJ?
HT	NWXtUIRZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYDJR\|UxRTBwMkmzPEDPxE1?	MlTqV2FPT0WU
A3-KAW	NYLsfVRRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1rxXWlEPTB;MD6yPVc1KM7:TR?=	NEfPcXBUSU6JRWK=
LB2241-RCC	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4HGb2lEPTB;MD6zNFE6QCEQvF2=	M1fFd3NCVkeHUh?=
BB65-RCC	Mlr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmDYTWM2OD1yLkOwPFA2KM7:TR?=	MUXTRW5ITVJ?
G-401	NHu5fWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVfOeY1wUUN3ME2wMlMxQTh4IN88US=>	M{LmOHNCVkeHUh?=
TYK-nu	NEDxbIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVvn[4w6UUN3ME2wMlMyQDZ2IN88US=>	NEDTc\|hUSU6JRWK=
NCI-SNU-1	NFrFTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWT3eWR{UUN3ME2wMlMzOzNzIN88US=>	NVvyWY5kW0GQR1XS
CHL-1	M{PJZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmTQTWM2OD1yLkOyO\|A{KM7:TR?=	NVvzdGxHW0GQR1XS
P30-OHK	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4LhPWlEPTB;MD6zNlcxPSEQvF2=	Mnf3V2FPT0WU
PA-1	M33HSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1jHcmlEPTB;MD6zN\|YyQSEQvF2=	NVPBOHdiW0GQR1XS
LB1047-RCC	MknCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnXITWM2OD1yLkO0NFQ4KM7:TR?=	MYLTRW5ITVJ?
EM-2	M1\xd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{nMSWlEPTB;MD6zOFE5QCEQvF2=	MUPTRW5ITVJ?
VA-ES-BJ	NIjBU5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV\5UHBFUUN3ME2wMlM1OjZ6IN88US=>	NGTnfYdUSU6JRWK=
NCI-H520	Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEKxU\|ZKSzVyPUCuN\|Q5OzRizszN	M2fhVHNCVkeHUh?=
ECC10	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVLJR\|UxRTBwM{WwN\|Uh\|ryP	NX7MUYp7W0GQR1XS
LNCaP-Clone-FGC	M17SRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mm\TTWM2OD1yLkO1N\|E1KM7:TR?=	NWXvb3ZIW0GQR1XS
ES8	NHfzTllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXX2TnhwUUN3ME2wMlM3PTV\|IN88US=>	MVfTRW5ITVJ?
HuO-3N1	MlPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHnYb2FKSzVyPUCuN\|g{PzlizszN	MkXCV2FPT0WU
L-363	MkX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml7QTWM2OD1yLkO5NFI3KM7:TR?=	NF73NFNUSU6JRWK=
SK-LU-1	NXrDTYZtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXvJR\|UxRTBwM{myNFgh\|ryP	NHf2cG9USU6JRWK=
MCF7	NEewWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYrS[pVmUUN3ME2wMlQxPTNizszN	NET4bGFUSU6JRWK=
HuO9	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV7qbJJDUUN3ME2wMlQxPjZ5IN88US=>	NEWxWFlUSU6JRWK=
BHT-101	M13QOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIf4U4tKSzVyPUCuOFA4QDdizszN	NF\1UXFUSU6JRWK=
MZ2-MEL	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MY\JR\|UxRTBwNEC4PFIh\|ryP	NWLPcJJOW0GQR1XS
NOS-1	M1jWWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MojoTWM2OD1yLkSxNFc1KM7:TR?=	NFy5T21USU6JRWK=
NEC8	NHTxfWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlTvTWM2OD1yLkSxOlk2KM7:TR?=	NXTlTlA3W0GQR1XS
COR-L88	NVmwZZo4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYnJR\|UxRTBwNEKyOlch\|ryP	MWDTRW5ITVJ?
MFM-223	NEK3TZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYXlOHJwUUN3ME2wMlQzPjF5IN88US=>	NInWSYVUSU6JRWK=
HSC-3	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn36TWM2OD1yLkSyPVA5KM7:TR?=	NUXE[md{W0GQR1XS
OVCAR-5	NXTNWXFDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3yyUWlEPTB;MD60Nlk{OyEQvF2=	MkPaV2FPT0WU
MFE-280	M4\iOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVHJR\|UxRTBwNEOwN\|Ih\|ryP	MYHTRW5ITVJ?
KP-N-YS	M4\O[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXfJR\|UxRTBwNEOwO{DPxE1?	M1nKXnNCVkeHUh?=
EPLC-272H	NEfLSnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1r0XWlEPTB;MD60N\|A4PyEQvF2=	M2i0dnNCVkeHUh?=
KE-37	NIK2c4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWHPVXZ1UUN3ME2wMlQ{OjR5IN88US=>	MUjTRW5ITVJ?
HuH-7	NXHOWFNqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M37ZVmlEPTB;MD60N\|M4OiEQvF2=	M1v1WHNCVkeHUh?=
CHP-212	MkHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXPJR\|UxRTBwNEO2PVch\|ryP	MWnTRW5ITVJ?
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KYSE-150	NYO4XHN3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHfBepdKSzVyPUCuOlYyQDZizszN	M3y3THNCVkeHUh?=
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NCI-H1648	M4HHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVLJR\|UxRTBwN{CxO\|Mh\|ryP	Mk\LV2FPT0WU
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NCI-H747	Mn71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXfDeZdyUUN3ME2wMlc2QTlzIN88US=>	M4PZb3NCVkeHUh?=
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DMS-273	MkXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mk[yTWM2OD1yLke2PVIzKM7:TR?=	M3GzZXNCVkeHUh?=
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NCI-H1770	MlLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX;JR\|UxRTBwOECyNUDPxE1?	MkPLV2FPT0WU
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NCI-H2347	NUPDfoN7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVfJR\|UxRTBwOEK0NFEh\|ryP	NHfZWJFUSU6JRWK=
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KYSE-450	M3Lrbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mk\wTWM2OD1yLkiyO\|I2KM7:TR?=	M1vxNnNCVkeHUh?=
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RT-112	NVK2V\|Y4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIHDVlJKSzVyPUCuPFQ6OzdizszN	Mo\VV2FPT0WU
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CAL-120	NHjzbnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVrZO243UUN3ME2wMlg3ODRzIN88US=>	NULGemd4W0GQR1XS
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UACC-893	MlnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MV\JR\|UxRTBwOUK4OVUh\|ryP	MYfTRW5ITVJ?
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DMS-114	NFvFfmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlPCTWM2OD1yLkmzOlc4KM7:TR?=	M1;WTXNCVkeHUh?=
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KYSE-180	M1j0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGPrXG5KSzVyPUGuNVExOjFizszN	NG\oTmtUSU6JRWK=
NH-12	NY[5fm5{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYTJR\|UxRTFwMUGyN\|ch\|ryP	MX;TRW5ITVJ?
BE-13	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXLJR\|UxRTFwMUG3OVkh\|ryP	NY\5fodvW0GQR1XS
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MDA-MB-453	MmPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoPCTWM2OD1zLkG1OlI1KM7:TR?=	M1zYcHNCVkeHUh?=
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HT-144	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV;JR\|UxRTFwMUewO{DPxE1?	NVjlSmJSW0GQR1XS
HEC-1	M3LBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYDJR\|UxRTFwMUe2Nlch\|ryP	MVvTRW5ITVJ?
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Detroit562	NV;X[ndtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVPjTm9jUUN3ME2xMlE6PDN7IN88US=>	Mnr1V2FPT0WU
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HDLM-2	Mnm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1ryeWlEPTB;MT6yNVMzPiEQvF2=	MoHnV2FPT0WU
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MDA-MB-415	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{HtR2lEPTB;MT6yNVcxOiEQvF2=	NU\YfWtGW0GQR1XS
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NCI-H2030	MlfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWfJR\|UxRTFwMkSxNFYh\|ryP	MUjTRW5ITVJ?
LS-123	M3PVSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWTJR\|UxRTFwMkS3OVMh\|ryP	M{D4c3NCVkeHUh?=
SK-MEL-3	M4DNV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUXJR\|UxRTFwMkS3O\|Yh\|ryP	MVHTRW5ITVJ?
KS-1	Ml35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{j1UGlEPTB;MT6yOVE4OSEQvF2=	MWHTRW5ITVJ?
LU-65	MnrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{XnXmlEPTB;MT6yOVYxPiEQvF2=	NFPUcohUSU6JRWK=
NCI-H596	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3\2UWlEPTB;MT6yOVkzQSEQvF2=	NYfrOIRIW0GQR1XS
KYSE-410	MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnrrTWM2OD1zLkK3NFE1KM7:TR?=	NUXVR5JlW0GQR1XS
NCI-H2228	NV;w[W1zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3rPUGlEPTB;MT6yO\|E3PyEQvF2=	NGK2SmVUSU6JRWK=
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BFTC-909	MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFy4XnZKSzVyPUGuNlk1OzRizszN	NH[0bVdUSU6JRWK=
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SKG-IIIa	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHvqfGJKSzVyPUGuN\|E1OjhizszN	M3G4R3NCVkeHUh?=
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NCI-H446	M335d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnT5TWM2OD1zLkOyPVAzKM7:TR?=	NIrXSFhUSU6JRWK=
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GCT	M1mzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXfJR\|UxRTFwM{SzOFUh\|ryP	M1\vbXNCVkeHUh?=
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AM-38	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlXPTWM2OD1zLkO3NVk6KM7:TR?=	NH\BVWJUSU6JRWK=
CHP-134	NXq5WYF1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MY\JR\|UxRTFwM{e4OFQh\|ryP	MmG0V2FPT0WU
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LB831-BLC	MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmO1TWM2OD1zLkO5NFY4KM7:TR?=	NF7vWHRUSU6JRWK=
TE-12	NF60NZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHrZZlFKSzVyPUGuOFA3ODFizszN	MofQV2FPT0WU
LCLC-97TM1	NWPnTFlGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVG5TphPUUN3ME2xMlQyODR4IN88US=>	NXvRWJJzW0GQR1XS
HCT-116	M4exR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUPJR\|UxRTFwNEK4OVQh\|ryP	MWfTRW5ITVJ?
ALL-PO	MnLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVHJR\|UxRTFwNEO3O\|Qh\|ryP	M1Gy[nNCVkeHUh?=
EW-16	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1\lfmlEPTB;MT60N\|g1OiEQvF2=	M2HNenNCVkeHUh?=
NCI-H661	MoHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYHEdlZSUUN3ME2xMlQ1Pzd3IN88US=>	MoT2V2FPT0WU
TE-8	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn;ZTWM2OD1zLkS1OVYh\|ryP	NEDrellUSU6JRWK=
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SW1990	MorUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXzIRY8zUUN3ME2xMlQ4PTN\|IN88US=>	NFzUXWxUSU6JRWK=
UM-UC-3	M4Tx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmXHTWM2OD1zLkS3Olc2KM7:TR?=	MVTTRW5ITVJ?
HuP-T4	NH\oOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHPJTpdKSzVyPUGuOFg3ODdizszN	MmTjV2FPT0WU
NCI-H1299	M4PFdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEPicndKSzVyPUGuOVAxQDZizszN	MYfTRW5ITVJ?
RO82-W-1	NEXaclNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFXw[3RKSzVyPUGuOVIxQDFizszN	MlPJV2FPT0WU
Becker	NYPMPZNVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUDJR\|UxRTFwNUKxPFch\|ryP	M4DhN3NCVkeHUh?=
SNU-387	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWTJR\|UxRTFwNUKyOFEh\|ryP	MWDTRW5ITVJ?
CAL-85-1	MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoX5TWM2OD1zLkWyOVk6KM7:TR?=	Ml;PV2FPT0WU
647-V	NVTJN2tmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXzJR\|UxRTFwNUO4PEDPxE1?	MW\TRW5ITVJ?
SBC-5	MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3:5ZmlEPTB;MT61OFU6OyEQvF2=	MlvuV2FPT0WU
NCI-H23	NX;2[o1FT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIjuUFJKSzVyPUGuOVU4OTRizszN	NWDpPYVtW0GQR1XS
CGTH-W-1	M1;BTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX3MRmJyUUN3ME2xMlU2QDF7IN88US=>	MXXTRW5ITVJ?
SK-N-FI	M2LsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWPKWJZKUUN3ME2xMlU2QTB6IN88US=>	MmjUV2FPT0WU
KM-H2	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4jUWGlEPTB;MT61OlQ4PCEQvF2=	NV;YNZNYW0GQR1XS
KY821	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWLKZ5ZSUUN3ME2xMlU3PjF5IN88US=>	NWrRbIU{W0GQR1XS
RH-1	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHzIV4xKSzVyPUGuOVY4PjJizszN	MXrTRW5ITVJ?
KYSE-270	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnHETWM2OD1zLkW3OFI{KM7:TR?=	NX:2NG1NW0GQR1XS
SF539	M{LFNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFzvW5FKSzVyPUGuOVc6PjlizszN	NXPmPXhEW0GQR1XS
JEG-3	M2W1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3HLZ2lEPTB;MT61PFA6PCEQvF2=	NYDE[IU2W0GQR1XS
SCC-25	M2DNeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXLJR\|UxRTFwNUi0N\|Ih\|ryP	M2\KRXNCVkeHUh?=
SW1573	Mn\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHL0TYRKSzVyPUGuOlAyPThizszN	NHO5XVZUSU6JRWK=
EW-1	NFH4XFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIjsdoNKSzVyPUGuOlE{PTFizszN	NUDmWGFsW0GQR1XS
YKG-1	NEGyWG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MljXTWM2OD1zLk[xOFM5KM7:TR?=	NFPDfZZUSU6JRWK=
EW-11	M{LUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWHJR\|UxRTFwNkG3OFEh\|ryP	MWfTRW5ITVJ?
DJM-1	M3TtbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVnxdpdpUUN3ME2xMlYyQDJ3IN88US=>	NGHK[nVUSU6JRWK=
Calu-3	NYX5c3B{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWHMd4hIUUN3ME2xMlY2OjF\|IN88US=>	MX;TRW5ITVJ?
HT-3	M2nSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXnNW41PUUN3ME2xMlY2PjZizszN	NIrXb3FUSU6JRWK=
NCI-H69	M2PYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHrLXVZKSzVyPUGuOlc{PDNizszN	M3jBbnNCVkeHUh?=
NCI-H2126	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlvPTWM2OD1zLk[3O\|k4KM7:TR?=	NELsNY9USU6JRWK=
RPMI-2650	NV\5PYdtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFXLSFFKSzVyPUGuOlg{OTdizszN	MWrTRW5ITVJ?
TE-6	NUTsO2I3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUfJR\|UxRTFwN{C4O\|Qh\|ryP	NWfNbWJuW0GQR1XS
MDA-MB-231	MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2jRWmlEPTB;MT63NVk6OyEQvF2=	M4jhcHNCVkeHUh?=
A2780	NHrZUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGr5T2RKSzVyPUGuO\|IzODdizszN	MWrTRW5ITVJ?
GOTO	NUO0VnJYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml24TWM2OD1zLkezOVYh\|ryP	NVrCZ2RLW0GQR1XS
KYSE-70	M{PCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFPtUnJKSzVyPUGuO\|Q1PDJizszN	M2\WOHNCVkeHUh?=
GMS-10	M{fSWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1TqbGlEPTB;MT63OFY3OiEQvF2=	NGC2XWtUSU6JRWK=
CaR-1	Mlq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlXiTWM2OD1zLke0PFEzKM7:TR?=	MYLTRW5ITVJ?
SW900	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXzYPIhmUUN3ME2xMlc1QTl\|IN88US=>	MV7TRW5ITVJ?
BB49-HNC	NEj5[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2DNeGlEPTB;MT63OVE3QCEQvF2=	NXy1WXBlW0GQR1XS
SNB75	NHiw[\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXzTS5c4UUN3ME2xMlc2PDl{IN88US=>	MmjLV2FPT0WU
SK-PN-DW	NEj1NJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoHmTWM2OD1zLke1OlgzKM7:TR?=	NYXtfoxzW0GQR1XS
5637	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVfJR\|UxRTFwN{eyOlgh\|ryP	MUXTRW5ITVJ?
BT-474	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnrUTWM2OD1zLke4NVcyKM7:TR?=	NFvw[oRUSU6JRWK=
KM12	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M17QfWlEPTB;MT63PVc1OSEQvF2=	Mn7IV2FPT0WU
COLO-680N	M2jBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkmwTWM2OD1zLkiyN\|gyKM7:TR?=	NHm0[5NUSU6JRWK=
Saos-2	NXTaW3JZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnXSTWM2OD1zLkiyOFQ2KM7:TR?=	NVG2Nm43W0GQR1XS
CAL-54	NFL2dIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWjJR\|UxRTFwOEOzNVMh\|ryP	MYTTRW5ITVJ?
U-118-MG	NHjUS2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3:xOmlEPTB;MT64OFYzOiEQvF2=	M1;BUXNCVkeHUh?=
TGBC24TKB	M{exWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkK2TWM2OD1zLki1OVAyKM7:TR?=	MnPlV2FPT0WU
NCI-H2052	MnfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIHmXZNKSzVyPUGuPFY1OSEQvF2=	NFX3VYJUSU6JRWK=
BB30-HNC	NIPtZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3myfGlEPTB;MT64OlQ3OiEQvF2=	MlTTV2FPT0WU
KNS-81-FD	M1jWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWDOU3NIUUN3ME2xMlg6OTZ3IN88US=>	MofZV2FPT0WU
HN	NVO4fpdrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFvyRpZKSzVyPUGuPFk2PDVizszN	NWPQWYpuW0GQR1XS
ACHN	NV\LdlVFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWrJR\|UxRTFwOUC3PFYh\|ryP	NYr6eIoyW0GQR1XS
HSC-2	NFXXZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVPkVZNZUUN3ME2xMlkyODl4IN88US=>	NV;xbI11W0GQR1XS
HCC2998	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX;JR\|UxRTFwOUOzNlUh\|ryP	MnjWV2FPT0WU
HEL	M17BZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3ryNWlEPTB;MT65OFE5PCEQvF2=	MkXkV2FPT0WU
SW684	NXyzbWJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoPuTWM2OD1zLkm3N\|cyKM7:TR?=	NFz5UodUSU6JRWK=
NCI-H1693	NGPvbFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4j3NWlEPTB;MT65PFA5PiEQvF2=	M{S3O3NCVkeHUh?=
8-MG-BA	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVnJR\|UxRTFwOUiyNUDPxE1?	MUTTRW5ITVJ?
OVCAR-8	M37KRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2fU[WlEPTB;Mj6wNFI6PSEQvF2=	MknMV2FPT0WU
DSH1	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{DBU2lEPTB;Mj6wNVc4PCEQvF2=	MWjTRW5ITVJ?
KYSE-520	M3XqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MofPTWM2OD1{LkCyNFQ6KM7:TR?=	NHi4SG9USU6JRWK=
GB-1	MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoLmTWM2OD1{LkCyOVc4KM7:TR?=	NHzrTFRUSU6JRWK=
RCC10RGB	MkKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGnxfIFKSzVyPUKuNFQ5PzFizszN	MV7TRW5ITVJ?
SW954	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUTJR\|UxRTJwMEWwN\|Yh\|ryP	MYnTRW5ITVJ?
IST-MES1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3zKWWlEPTB;Mj6wOVU3QCEQvF2=	MoP5V2FPT0WU
AU565	M4jCb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXrJR\|UxRTJwMEW5NFUh\|ryP	MYrTRW5ITVJ?
CW-2	NXeyPWk1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{ToSWlEPTB;Mj6wOlg4PSEQvF2=	NF:2NZNUSU6JRWK=
TE-1	MnXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVXJR\|UxRTJwMEmzO\|ch\|ryP	Mn:xV2FPT0WU
KP-4	M2HTTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUXJR\|UxRTJwMUCzNVIh\|ryP	NHSxe5JUSU6JRWK=
SNU-C2B	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVrJR\|UxRTJwMUC4NlMh\|ryP	NYnqbpBEW0GQR1XS
NCI-H1395	MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mki4TWM2OD1{LkGwPVg3KM7:TR?=	MUPTRW5ITVJ?
CAS-1	NFjTN3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MknvTWM2OD1{LkGxOVQ3KM7:TR?=	NVTiV5JlW0GQR1XS
NCI-H1155	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFf4RnFKSzVyPUKuNlI3QSEQvF2=	M4PEWXNCVkeHUh?=
SK-MEL-1	NWPw[mdVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV3JR\|UxRTJwMkixPFEh\|ryP	NYHKcFB5W0GQR1XS
KINGS-1	NETZdFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWHnUHRrUUN3ME2yMlMxODh6IN88US=>	NW\JSHMyW0GQR1XS
ESS-1	M4XiR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXrJR\|UxRTJwM{C1NUDPxE1?	NYrjOGJGW0GQR1XS
PANC-10-05	NUPMTlRWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIXLc3BKSzVyPUKuN\|cxOjRizszN	M1jQO3NCVkeHUh?=
HT-1376	Mne3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWXJR\|UxRTJwM{i3NFgh\|ryP	NGL5XoZUSU6JRWK=
LS-513	NUX5NZA1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFjq[nZKSzVyPUKuN\|g5PzRizszN	NXLwe4dOW0GQR1XS
KNS-42	NFPxU2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MU\JR\|UxRTJwM{mxNFUh\|ryP	MVfTRW5ITVJ?
639-V	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWPJR\|UxRTJwNEK3OVgh\|ryP	MlrvV2FPT0WU
SJRH30	M4XsVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFT0c4tKSzVyPUKuOFUyPjFizszN	Mlr6V2FPT0WU
SW1783	MkLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFnzRoZKSzVyPUKuOFcxPzhizszN	M3HIVXNCVkeHUh?=
NB6	M2\FV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIfq[odKSzVyPUKuOFgzQCEQvF2=	MoLwV2FPT0WU
SK-MEL-30	NITXVZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUDibIQ3UUN3ME2yMlQ5QDNizszN	MYnTRW5ITVJ?
HCE-4	NG\vUm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF7HNo5KSzVyPUKuOFk1ODJizszN	NYj6VVhxW0GQR1XS
NB10	NYLKenNxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn7aTWM2OD1{LkS5OFI6KM7:TR?=	MXjTRW5ITVJ?
H-EMC-SS	NWPMNW1UT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYj0R4VzUUN3ME2yMlU1PjVizszN	MofuV2FPT0WU
SK-HEP-1	NHnMVGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnnlTWM2OD1{LkW1NlM3KM7:TR?=	Mo\JV2FPT0WU
HCC1395	MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV62fXd4UUN3ME2yMlU2PjV3IN88US=>	NITZVWhUSU6JRWK=
HuCCT1	NFWzXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWDJR\|UxRTJwNU[zPUDPxE1?	MU\TRW5ITVJ?
SiHa	M2nXV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHPQfXFKSzVyPUKuOVg4OTlizszN	NVPUdXd2W0GQR1XS
EFO-21	M2TZPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVm0NYdsUUN3ME2yMlU5PzZ2IN88US=>	NGT1NFdUSU6JRWK=
NCI-H1666	NVW4UlJDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn;FTWM2OD1{LkW5NFc3KM7:TR?=	MmTFV2FPT0WU
UMC-11	MnW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXPJR\|UxRTJwNUm4Olgh\|ryP	NGH2NVVUSU6JRWK=
COLO-679	NUjxV4RPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH7me2VKSzVyPUKuOlEzOzNizszN	MlP6V2FPT0WU
A388	NFPnOYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHvRcphKSzVyPUKuOlUzPTNizszN	NVnOWoFEW0GQR1XS
LB2518-MEL	M3P3fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVTJR\|UxRTJwNkW0NFgh\|ryP	NVriN5E4W0GQR1XS
EW-13	M2S2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYnUcVZnUUN3ME2yMlY5PzZ6IN88US=>	MmHoV2FPT0WU
MLMA	NUP2TYhNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M170bGlEPTB;Mj62PFg2PiEQvF2=	NFnyR2xUSU6JRWK=
HOP-92	NFfmcGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFTJcXdKSzVyPUKuO\|AyOSEQvF2=	NGDvU3JUSU6JRWK=
NOMO-1	NHy1dI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHj3bIRKSzVyPUKuO\|E1PDJizszN	NEXJWXJUSU6JRWK=
NCI-H810	Ml\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVHHO4NQUUN3ME2yMlczOTl6IN88US=>	NILPbG1USU6JRWK=
769-P	MoHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWTJR\|UxRTJwN{KyPEDPxE1?	MlG0V2FPT0WU
SAS	NEnXWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3PYZWlEPTB;Mj63OlUh\|ryP	MkjwV2FPT0WU
M059J	NHvoRppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV7OSVBiUUN3ME2yMlc5OzF6IN88US=>	MXzTRW5ITVJ?
RD	M4CzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYDmTWJGUUN3ME2yMlc6PDdzIN88US=>	NVzNTI9jW0GQR1XS
GT3TKB	MlzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmfLTWM2OD1{LkizOFM{KM7:TR?=	MWTTRW5ITVJ?
MZ7-mel	M4\XWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHPGNJJKSzVyPUKuPFY2ODJizszN	NUC4cFNbW0GQR1XS
KYSE-510	M1rwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWfJR\|UxRTJwOEm1NFQh\|ryP	Ml71V2FPT0WU
NCI-N87	NFT3R\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M13TSmlEPTB;Mj65NVgxPyEQvF2=	MXXTRW5ITVJ?
MKN1	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkfhTWM2OD1\|LkCwNVY{KM7:TR?=	NUXkR4kxW0GQR1XS
NCI-H2170	NYrVTJppT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFPSSoFKSzVyPUOuNFA1PTFizszN	MVvTRW5ITVJ?
OVCAR-3	MoXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXfjTGF1UUN3ME2zMlAzOTF3IN88US=>	M3TzWHNCVkeHUh?=
KLE	M1q2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWTJR\|UxRTNwME[4NVIh\|ryP	MVLTRW5ITVJ?
LB771-HNC	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2TUXmlEPTB;Mz6wPVM1OyEQvF2=	NEK0OXBUSU6JRWK=
MC116	M1fkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWHzXnJyUUN3ME2zMlEyOTF{IN88US=>	Mn\0V2FPT0WU
SCC-9	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX3DR3pYUUN3ME2zMlEyOzZ4IN88US=>	M3vscHNCVkeHUh?=
U031	NVLX[JBST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MULJR\|UxRTNwMUK0NlMh\|ryP	MYHTRW5ITVJ?
LCLC-103H	M{jPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH\LR3NKSzVyPUOuNlM5QTRizszN	NIGzd4hUSU6JRWK=
U-266	MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1X2UmlEPTB;Mz6yO\|Y{OyEQvF2=	Mlu4V2FPT0WU
JVM-2	M2TYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFXTRXFKSzVyPUOuN\|IyPjRizszN	NXXzS\|NPW0GQR1XS
UACC-257	NIXuc21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWjJR\|UxRTNwNE[0N\|Eh\|ryP	MoL4V2FPT0WU
LB996-RCC	MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MojFTWM2OD1\|LkS2OVAzKM7:TR?=	NXHTNlk3W0GQR1XS
BT-549	NY\2RYhrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1;0b2lEPTB;Mz61NFIxQSEQvF2=	NHjmSW1USU6JRWK=
NCI-H526	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkixTWM2OD1\|LkW0NVU5KM7:TR?=	NVLVNlBSW0GQR1XS
RH-18	M{TzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVzJR\|UxRTNwNkG3PVgh\|ryP	M{jpbHNCVkeHUh?=
SW626	M2\NSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1HJPWlEPTB;Mz63NVEzQCEQvF2=	NFrWO5VUSU6JRWK=
SK-N-AS	MormS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIrwTmJKSzVyPUOuO\|MzPDdizszN	NVvkc2ZZW0GQR1XS
IGR-1	NWXIeGNbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIGyfnVKSzVyPUOuO\|QzPDhizszN	MnrFV2FPT0WU
NCI-H2291	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MorRTWM2OD1\|Lke1N\|M3KM7:TR?=	M1ixeXNCVkeHUh?=
NCI-H441	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NI\pT\|VKSzVyPUOuPFI1OzNizszN	M3XvOnNCVkeHUh?=
D-247MG	MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFXnXWNKSzVyPUOuPFYxOzFizszN	MVnTRW5ITVJ?
COLO-320-HSR	NUezcnlMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkfHTWM2OD1\|LkmxNlcyKM7:TR?=	MkG1V2FPT0WU
A253	M3jZZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3HNZWlEPTB;Mz65NVQ{PiEQvF2=	MXHTRW5ITVJ?
HT55	MkDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3f0T2lEPTB;Mz65NVc4OyEQvF2=	NYLzWYwxW0GQR1XS
MZ1-PC	NEPMN2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXPJR\|UxRTNwOUW4OlQh\|ryP	NULhT21oW0GQR1XS
RERF-LC-MS	M3HBXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M176OWlEPTB;Mz65OlUzPSEQvF2=	MkHaV2FPT0WU
SF268	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUnJR\|UxRTRwMUK4PFEh\|ryP	NWLtOnNsW0GQR1XS
RMG-I	M2Cye2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml;OTWM2OD12LkKxOFU1KM7:TR?=	M13aN3NCVkeHUh?=
CFPAC-1	MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVPZSZlVUUN3ME20MlIyPjh3IN88US=>	MnX3V2FPT0WU
S-117	NELKb3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1z1VGlEPTB;ND6yNlAzPCEQvF2=	MVHTRW5ITVJ?
NCI-H2122	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXS0RYl{UUN3ME20MlMxQTNzIN88US=>	Mln1V2FPT0WU
J82	NH;DXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVXSXYY4UUN3ME20MlM{PDRzIN88US=>	M{jEW3NCVkeHUh?=
CAL-72	NYfiPVZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV7JR\|UxRTRwM{W0O\|ch\|ryP	NEjycYlUSU6JRWK=
GP5d	M4LYZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MULJR\|UxRTRwNEGyPVgh\|ryP	MkT3V2FPT0WU
UACC-62	NWj2TVBzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlH6TWM2OD12LkS2OVQ2KM7:TR?=	M{LvfHNCVkeHUh?=
MS-1	MnHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWnJR\|UxRTRwNEmxNVUh\|ryP	Ml[zV2FPT0WU
RCM-1	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV3Zc213UUN3ME20MlUzQTJizszN	NWfFSVA1W0GQR1XS
IST-SL1	M2[zU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH7TbmRKSzVyPUSuOlU{PTlizszN	NGq2OphUSU6JRWK=
SW756	NHTsUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1vKWWlEPTB;ND62PVE{PSEQvF2=	NUP1RZhMW0GQR1XS
HCC38	M{DuO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mo\ETWM2OD12LkexNVk4KM7:TR?=	MXLTRW5ITVJ?
YAPC	NHvPWldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV;JR\|UxRTRwN{GzNVMh\|ryP	M3n0O3NCVkeHUh?=
DK-MG	NXS4SGdGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXPJR\|UxRTRwN{ixNVIh\|ryP	NFXqNFZUSU6JRWK=
HCC1937	MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXXJR\|UxRTRwOEWxNlUh\|ryP	NUjjOmlJW0GQR1XS
OAW-28	MoTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NULFe4VpUUN3ME20MlkzPDN3IN88US=>	MVTTRW5ITVJ?
MEG-01	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVLJR\|UxRTVwMEizNlgh\|ryP	MnLaV2FPT0WU
GI-1	NECySWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4r6fWlEPTB;NT6yN\|Q5PiEQvF2=	Mn32V2FPT0WU
FADU	M{HOTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXHJR\|UxRTVwMke4N\|ch\|ryP	MXrTRW5ITVJ?
CAPAN-1	MmX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUDJR\|UxRTVwM{m0N\|Ih\|ryP	M1zJOHNCVkeHUh?=
TGBC11TKB	NHvvdmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NU\SRY4xUUN3ME21MlQ2Pzh4IN88US=>	MWfTRW5ITVJ?
DBTRG-05MG	NF3o[WFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV7JR\|UxRTVwNUC1NkDPxE1?	NIDmR2dUSU6JRWK=
ONS-76	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFPCW2NKSzVyPUWuOVU5ODFizszN	NV:zdXRlW0GQR1XS
Ca-Ski	Mmn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NW\6ZW54UUN3ME21MlYzPTZ4IN88US=>	MW\TRW5ITVJ?
COLO-741	NFTFd29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MW\JR\|UxRTVwN{G5PVUh\|ryP	NIGwOZhUSU6JRWK=
HT-29	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEfR[mRKSzVyPUWuPFA1PzVizszN	M3j6[HNCVkeHUh?=
HCC1187	M2PjVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NESxSINKSzVyPUWuPFExODhizszN	NXfvc5lDW0GQR1XS
Capan-2	MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGXNWmxKSzVyPUWuPVU6QTRizszN	MlqwV2FPT0WU
NCI-H630	M4S5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4W5Z2lEPTB;Nj6xNVQ1OSEQvF2=	NUDaZYJVW0GQR1XS
COLO-678	NWnSeVh4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MW\JR\|UxRTZwMUWwPVIh\|ryP	MoPoV2FPT0WU
D-502MG	NEm5PHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3rwW2lEPTB;Nj6xO\|M{PiEQvF2=	NUnKPZRwW0GQR1XS
NB17	NV36fYZnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{i2d2lEPTB;Nj6yOFk1OyEQvF2=	NVeyb\|JnW0GQR1XS
SK-MEL-24	NYTjV4Z6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4HGN2lEPTB;Nj6yOlQ6KM7:TR?=	NUjHbndbW0GQR1XS
NCI-SNU-5	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1iyfWlEPTB;Nj6yO\|EyQCEQvF2=	M1;WSXNCVkeHUh?=
D-392MG	MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIHqd29KSzVyPU[uN\|M{QTlizszN	MoPqV2FPT0WU
A498	M174cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2H4OmlEPTB;Nj60NFMxOiEQvF2=	NUnDRlJUW0GQR1XS
OCI-AML2	M{XGTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{XuZWlEPTB;Nj60OVQ1PSEQvF2=	NVzycXdHW0GQR1XS
HCC2157	Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NETENmlKSzVyPU[uOFU3OTZizszN	NXHjfHIzW0GQR1XS
C3A	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVTJR\|UxRTZwNUKwNFQh\|ryP	MlLuV2FPT0WU
NCI-H1650	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmnDTWM2OD14LkewOVIzKM7:TR?=	MWjTRW5ITVJ?
DU-145	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmXBTWM2OD14Lke3NFMh\|ryP	MXHTRW5ITVJ?
COLO-829	NGr1VJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2TXeGlEPTB;Nj63O\|g4OyEQvF2=	NI\od3RUSU6JRWK=
LS-1034	NF3tdpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NI[4UXFKSzVyPUeuNFQ1OTJizszN	NXTsTHM6W0GQR1XS
HCC1954	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mni1TWM2OD15LkS4NVM1KM7:TR?=	NH;TS2hUSU6JRWK=
KURAMOCHI	MmDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXzaVGpkUUN3ME23MlQ5PTN\|IN88US=>	M1jiTHNCVkeHUh?=
Mo-T	NYi5WXZIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYPJR\|UxRTdwNUG0PVgh\|ryP	NH:w[INUSU6JRWK=
OE19	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NH\ZS3dKSzVyPUeuOlU2ODNizszN	M{fEZnNCVkeHUh?=
COR-L105	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NELxXVBKSzVyPUeuO\|E1OjFizszN	NGH5PIZUSU6JRWK=
NCI-H2342	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3T2SGlEPTB;Nz63NVUzOSEQvF2=	M17WT3NCVkeHUh?=
U-87-MG	NYfufnA{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIriR2FKSzVyPUiuNFM{OzRizszN	M4PkNnNCVkeHUh?=
MKN28	M3\5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFzVOHBKSzVyPUiuNVE2OTVizszN	NGDyenJUSU6JRWK=
HT-1197	NGrvfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIe2N3pKSzVyPUiuNlU6ODdizszN	NHvaW5JUSU6JRWK=
ChaGo-K-1	NV22d2I5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnrNTWM2OD16LkO0NlQ2KM7:TR?=	MmPBV2FPT0WU
NCI-H226	NH\WeJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1[zNWlEPTB;OD60OFM{OSEQvF2=	NHy1[o1USU6JRWK=
NCI-H2029	NH6yPHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MonYTWM2OD17LkC2O\|U6KM7:TR?=	NHKzRmhUSU6JRWK=
TE-11	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3LIOmlEPTB;OT60OVU5QCEQvF2=	M3WxcHNCVkeHUh?=
ZR-75-30	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1HiW2lEPTB;OT65NlY{PCEQvF2=	NHTxfoxUSU6JRWK=
SW837	MmjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEjmU3dKSzVyPUGwMlIzQTNizszN	MlTMV2FPT0WU
NCI-H1651	NW\2cGtoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3z4VWlEPTB;MUCuNlMzPiEQvF2=	NFTrZ\|lUSU6JRWK=
NCI-H727	NUjCXHJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFXNfodKSzVyPUGwMlQ1QTVizszN	NGj5S\|NUSU6JRWK=
NCI-H358	NVT0fpVYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1TEZ2lEPTB;MUCuPFM3PSEQvF2=	M3f4Z3NCVkeHUh?=
NCI-H2087	Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnH2TWM2OD1zMT6wOFM1KM7:TR?=	NF\pcZBUSU6JRWK=
FTC-133	M{LIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NE\EWHFKSzVyPUGxMlQxPTFizszN	MYrTRW5ITVJ?
LAN-6	NUPSWYJqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUTJR\|UxRTF{LkGyOEDPxE1?	M1HGZnNCVkeHUh?=
NCI-H1838	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV3JR\|UxRTF{LkWxOVEh\|ryP	NIWybVBUSU6JRWK=
Calu-6	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEX3VplKSzVyPUG0MlExOjFizszN	M1vjN3NCVkeHUh?=
HCC70	MnK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWXFb\|RNUUN3ME2xOE41PTFizszN	NHTsWVlUSU6JRWK=
KARPAS-299	MoD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXnJc25uUUN3ME2xOU4zOTV7IN88US=>	Mkn0V2FPT0WU
CAL-27	NYjMc5VCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV3LNZNtUUN3ME2xOU4{QDR\|IN88US=>	M4LMZnNCVkeHUh?=
NCI-H82	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWnCbYJRUUN3ME2xOU42OzJizszN	NX3mN45kW0GQR1XS
no-10	NWTqU4dST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MofWTWM2OD1zNT65N\|gh\|ryP	NXLObIVkW0GQR1XS
U251	NUWxZpQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYPJR\|UxRTF4LkO2O\|Uh\|ryP	MVzTRW5ITVJ?
TE-9	NF\FZ\|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEPKRZNKSzVyPUG3MlUyPjZizszN	MX\TRW5ITVJ?
TE-10	NXnNXGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGPuN5BKSzVyPUG5MlA3ODdizszN	MYHTRW5ITVJ?
COLO-824	NVTDZpdoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoXETWM2OD1{MD65Nlc3KM7:TR?=	M3jSUHNCVkeHUh?=
HuP-T3	NUHE[5U4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml7kTWM2OD1{MT6wO\|Q5KM7:TR?=	NUfTUWtlW0GQR1XS
KALS-1	NHrDNlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUmxVYl1UUN3ME2yNU4yPzVizszN	NGPkZohUSU6JRWK=
L-428	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVnJR\|UxRTJzLkSwNVYh\|ryP	NHrPWGJUSU6JRWK=
JAR	MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MknzTWM2OD1{MT61NFIh\|ryP	M2njOnNCVkeHUh?=
DoTc2-4510	NIfnNZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXzJR\|UxRTJ\|Lki0O\|Uh\|ryP	MYfTRW5ITVJ?
ABC-1	NVPTeY5jT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHXsbXhKSzVyPUK2Mlc6PTdizszN	M4DuUnNCVkeHUh?=
MHH-NB-11	Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4HuZmlEPTB;M{OuN\|Q3PCEQvF2=	MUfTRW5ITVJ?
SW1463	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnTDTWM2OD1\|Mz65PFMh\|ryP	M1PGOXNCVkeHUh?=
SW1417	NUG0[mQzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnzTTWM2OD1\|Nz6wPVUzKM7:TR?=	Mn3tV2FPT0WU
NB12	NV\xSItHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWrJR\|UxRTN7LkS2OVUh\|ryP	NGXZ[GNUSU6JRWK=
NY	MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkTPTWM2OD12MT6zNlAyKM7:TR?=	MnHTV2FPT0WU
H1048	M4DvdmFxd3C2b4Ppd{BCe3OjeR?=	MofOOVAxKG6P	NYq2bFR[PzJiaB?=		NHz4W2lvcGGwY3XzJGFDXC1{NkRihLNqdmS3Y3XkJIFxd3C2b4Ppdy=>	M3q1UVI2PzN5NUSy
H86	NIfiWIdCeG:ydH;zbZMhSXO\|YYm=	M4fMSlUxOCCwTR?=	NXfQb2c5PzJiaB?=		NYLSS4MzdmijbnPld{BCSlRvMk[z5qCUcW6mdXPl[EBieG:ydH;zbZM>	MUmyOVc{PzV2Mh?=
H196	M1\hT2Fxd3C2b4Ppd{BCe3OjeR?=	M3zNelUxOCCwTR?=	NXrjZ5B6PzJiaB?=		NYrQOm9mdmijbnPld{BCSlRvMk[z5qCUcW6mdXPl[EBieG:ydH;zbZM>	M{\mOlI2PzN5NUSy
H446	M1KyTGFxd3C2b4Ppd{BCe3OjeR?=	MXy1NFAhdk1?	M1i2XlczKGh?		MlO5cohidmOnczDBRnQuOjZ\|4pETbY5lfWOnZDDhdI9xfG:\|aYO=	NFvXeIozPTd\|N{W0Ni=>
TFK-1	NGjoVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MlfoO\|IhcA>?	NHnkSW5FVVOR	NIrZO3dKSzVyPUS3JI5O	MoWyNlUyPTJ{NES=
EGI-1	NHjRZ3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NWPBRYtCPzJiaB?=	MkflSG1UVw>?	M2jRRmlEPTB;NUOgcm0>	Mo\jNlUyPTJ{NES=
OCI/AML3	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MWOwMlIh\|ryP	NES5RXQ1QCCq		MmDF[Y5p[W6lZYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCrbnT1Z4VlKGK7IIPlcJVu\XSrbnni	NX\YTGNXOjR5M{mzPVM>
U937	NV\scIJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHi0eZQxNjJizszN	MoLDOFghcA>?		NYjIVXlb\W6qYX7j[ZMh[2WubDDndo94fGhiaX7obYJqfGmxbjDpcoR2[2WmIHL5JJNmdHWvZYTpcolj	NVrSVYg{OjR5M{mzPVM>
MOLM13	MnG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3XjcFAvOiEQvF2=	MkXVOFghcA>?		M1[ybYVvcGGwY3XzJINmdGxiZ4Lve5RpKGmwaHnibZRqd25iaX7keYNm\CCkeTDz[Yx2dWW2aX7pZi=>	M3qwVlI1PzN7M{mz
MCF7	NV\0dVUxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVO3d\|VROjBibl2=	MXK3NkBp	NEHhRnFHSlN?	MnzBdoVlfWOnczD0bIUhWEWOUEGtcYVlcWG2ZXSgbY5kemWjc3WgbY4h[2WubDD2bYFjcWyrdIm=	M2XZeVI1Pjh6MES2
TamR	M3S0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVTJR\|UxRTF64pEJcm0>	NHTsc3IzPDR3N{C2PS=>
MCF7-X	MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVexNVd3UUN3ME2yOEBvVQ>?	NVn2PY9DOjR2NUewOlk>
T47D-tamR	NWfYe2ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{fQN2lEPTB;MUmgcm0>	MlLnNlQ1PTdyNkm=
293T	M{[wdmZ2dmO2aX;uJGF{e2G7	NGPhPGwzOCCwTR?=	MoX1N{Bp		MnrU[Il{enWydIOgRYt1NW2nZHnheIVlKFSLRj3JRUB{fGGkaXzpeJktKHS{YX7zcI9k[XSrb36sJIFv\CCjY4Tpeol1gQ>?	MWeyOFM3OzR2OR?=
SW620	MlPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NITLVGsxNjByMT2xNO69VQ>?	NW\KWW0xOjRiaB?=		M4fHdIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iYYOgeIhmKGOxbnPlcpRz[XSrb36gdol{\XN?	MmD3NlQ{PjN2NEm=
Huh7	Mmr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M2O2cVUuOTByIH7N	NX;pNI02OC1{NDDo	NWHlR2xoTE2VTx?=	NFPKeVdqdmO{ZXHz[ZMh[2WubDDk[YF1cCCrbjDhJINwdmOnboTyZZRqd25vIHHu[EB1cW2nLXTldIVv\GWwdDDtZY5v\XJ?	NEPwb5UzPDJ7N{OwNC=>
Hep3B	NEmxblZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUe1MVExOCCwTR?=	Mlj3NE0zPCCq	MWrEUXNQ	Ml\ybY5kemWjc3XzJINmdGxiZHXheIghcW5iYTDjc45k\W62cnH0bY9vNSCjbnSgeIlu\S2mZYDlcoRmdnRibXHucoVz	NHz2NWgzPDJ7N{OwNC=>
Huh7	MXzGeY5kfGmxbjDBd5NigQ>?	MmO4NVAxKG6P	NFLYUJgyOiCq	MYfEUXNQ	NH;CTmtqdmS3Y3XzJIF2fG:yaHHnfeKh	Mn7sNlQzQTd\|MEC=
U87-MG	NGTXZ2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		Mn;3O\|IhcA>?		NUXBS4xiT0l3MPMAjV3jiIl5OTDuUeKh	NYS2WFA{OjR{NEm2OFA>
L3.6pl	NGq1OXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NH7JUVkyKM7:TR?=	NEfkN4w4OiCq		NF3VbVBqdmirYnn0d{B1cGViY3XscEBoem:5dHigZ49u[mmwZXSge4l1cCCETWOtO\|c4PjB5	NX;VNplpOjR{M{OzPVk>
TE671	Ml;yRZBweHSxc3nzJGF{e2G7	NEPoU3MyKM7:TR?=	NHXyeZc1QCCq		MkX2bY5kemWjc3XzJINmdGxiYYDvdJRwe2m\|IHnu[JVk\WRiYomgRWJVNTd\|Nx?=	MYKyOFE{OzJzOB?=
RD	MoH3RZBweHSxc3nzJGF{e2G7	NGXTUHMyKM7:TR?=	M4Dqd\|Q5KGh?		NWTET49ncW6lcnXhd4V{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhSUKWLUezOy=>	MkD6NlQyOzN{MUi=
RMS13	NYG0foNSSXCxcITvd4l{KEG\|c3H5	M3rP[FEh\|ryP	MkGwOFghcA>?		Ml[ybY5kemWjc3XzJINmdGxiYYDvdJRwe2m\|IHnu[JVk\WRiYomgRWJVNTd\|Nx?=	NXz3XoxLOjRzM{OyNVg>
RH30	MkeyRZBweHSxc3nzJGF{e2G7	NF7EOmYyKM7:TR?=	M1nXNlQ5KGh?		NFzXTJhqdmO{ZXHz[ZMh[2WubDDhdI9xfG:\|aYOgbY5lfWOnZDDifUBCSlRvN{O3	MXeyOFE{OzJzOB?=
Hep-2	NUjxR2VVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	Mnn3NE4xOS1zIN88US=>	NGjmcJEyOi17NjDo		M1i3colv[3KnYYPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5meg>?	NIG2PYYzPDFyM{e0PS=>
SCC-9	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M1HwdFAvODFvMTFOwG0>	MU[xNk06PiCq		MVvpcoNz\WG\|ZYOgZ4VtdCCmZXH0bEBqdiCjIHPvcoNmdnS{YYTpc44uKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI>	NH[3PG0zPDFyM{e0PS=>
Hep-2	NVHFPIpbTnWwY4Tpc44hSXO\|YYm=	MmjJNE4yNzBwNTFOwG0>	MYOyOEBp		M3y5ZoJtd2OtczDtWG9TSzFiYX7kJI1VV1KFMjDhZ5RqfmG2aX;u	M3TGWVI1OTB\|N{S5
SCC-9	MYnGeY5kfGmxbjDBd5NigQ>?	M1r6NVAvOS9yLkWg{txO	NVH2NnNbOjRiaB?=		NELCZVhjdG:la4OgcXRQWkNzIHHu[EBuXE:UQ{KgZYN1cX[jdHnvci=>	NUHoU4pIOjRzMEO3OFk>
PANC-1	Ml[2RZBweHSxc3nzJGF{e2G7	NH7BXJY2ODBibl2=	NH;Zenc1QCCq		NH;jcFh{\W6\|aYTpfoV{KHCjbnPy[YF1cWNiY3HuZ4VzKGOnbHzzJJRwKHKjZHnveIhmemGyeR?=	MViyN\|g5PjJ7NB?=
RMG2	M3ro[GFxd3C2b4Ppd{BCe3OjeR?=	NGnybnoyNTFyMECgcm0>	M2\3T\|czKGh?	MUjGRnM>	MoXmbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JINwdmOnboTyZZRqd25iZHXw[Y5l\W62bIm=	MV6yN\|YyPTZ\|MR?=
HAC2	NFniZm9CeG:ydH;zbZMhSXO\|YYm=	MlXFNU0yODByIH7N	NGXHT\|U4OiCq	MmfnSmJU	NHTsUYpqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkh[2:wY3XueJJifGmxbjDk[ZBmdmSnboTsfS=>	NEXzeZMzOzZzNU[zNS=>
HT-29	NUHUNIdbSXCxcITvd4l{KEG\|c3H5	M1izV\|Eh\|ryP	NInvc\|Q4OiCq		MUDheJRmdnWjdHXzJFUuTlVvaX7keYNm\CClZXzsJIRm[XSq	MoKwNlE6PDlzMkG=
DLD1	M1XyPGFxd3C2b4Ppd{BCe3OjeR?=	NXf3epk1OSEQvF2=	M3rTPVczKGh?		MWLheJRmdnWjdHXzJFUuTlVvaX7keYNm\CClZXzsJIRm[XSq	Mn\UNlE6PDlzMkG=
HT-29	NYnxcIU4TnWwY4Tpc44hSXO\|YYm=	MknqNUDPxE1?	MkjnO\|IhcA>?		MUfpcoR2[2W\|IHH1eI9xcGGpeTD0c{Bkd26oZYKgZ5l1d3C{b4TlZ5Rqd25?	M17YUlIyQTR7MUKx
DLD1	MWTGeY5kfGmxbjDBd5NigQ>?	NVvDSlVKOSEQvF2=	MkXoO\|IhcA>?		Ml35bY5lfWOnczDheZRweGijZ4mgeI8h[2:wZnXyJIN6fG:ycn;0[YN1cW:w	MnrBNlE6PDlzMkG=
Rh41	MnXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlzCTWM2OD1\|MD63JI5O	Ml\JNlE{Ozd4N{m=
Rh18	NIrR[FJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4i4dmlEPTB;NEGuOEBvVQ>?	MVGyNVM{PzZ5OR?=
Rh30	NGmwO5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVLrNIhEUUN3ME2xOEBvVQ>?	MWqyNVM{PzZ5OR?=
BT-12	MlH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVvPWXE1UUN3ME2yOE44KG6P	NHLm[XAzOTN\|N{[3PS=>
CHLA-266	M1G3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYK1bnBQUUN3ME2xMlEhdk1?	NWHi[nd{OjF\|M{e2O\|k>
TC-71	NGjXd3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEDCSJJKSzVyPUS2MlUhdk1?	M3Lud\|IyOzN5Nke5
CHLA-9	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnX3TWM2OD1zNT6zJI5O	NHzQbWszOTN\|N{[3PS=>
CHLA-10	MmXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NI[wS2xKSzVyPUOuPUBvVQ>?	NYjyc4xCOjF\|M{e2O\|k>
CHLA-258	MmrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3\BNGlEPTB;MUCuOEBvVQ>?	M2DkbVIyOzN5Nke5
GBM2	M{L4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXTpO2x{UUN3ME20NE44KG6P	M1PpTFIyOzN5Nke5
NB-1643	M{jsV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4X1RmlEPTB;M{OuPEBvVQ>?	NGHPWVUzOTN\|N{[3PS=>
NB-EBc1	M4HrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlHLTWM2OD1{Nz6xJI5O	MmPENlE{Ozd4N{m=
CHLA-90	Mmq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGrwVYFKSzVyPUO0MlUhdk1?	NUfMXYNUOjF\|M{e2O\|k>
CHLA-136	M3TBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2jxWmlEPTB;MU[yMlYhdk1?	M2PTPVIyOzN5Nke5
NALM-6	NYrLbWhQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXrxZmo2UUN3ME2zNk46KG6P	MX:yNVM{PzZ5OR?=
COG-LL-317	NXf2ZZJNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXLJR\|UxRTFwMzDuUS=>	MUeyNVM{PzZ5OR?=
RS4;11	MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3r6OGlEPTB;M{Wgcm0>	M2LRfVIyOzN5Nke5
MOLT-4	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2DxbmlEPTB;OD62JI5O	NETiZlkzOTN\|N{[3PS=>
CCRF-CEM	NVjFNVlST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXe5Xlh1UUN3ME20MlEhdk1?	MWSyNVM{PzZ5OR?=
Kasumi-1	NVH0[pF6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3T3NGlEPTB;MT60JI5O	M2D4[FIyOzN5Nke5
Karpas-299	M2XubGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{S2NGlEPTB;MkGuO{BvVQ>?	MlHwNlE{Ozd4N{m=
Ramos-RA1	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoTITWM2OD16LkKgcm0>	MVWyNVM{PzZ5OR?=
H838	NH3IVoxHfW6ldHnvckBCe3OjeR?=	M1nsTFEh\|ryP	NWf4UIVtPDhiaB?=		NXXnU3RRcW6mdXPld{Bk\WyuIHH1eI9xcGGpeR?=	Ml;pNlA{PjRzMUO=
H838	NYHPdYZLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{PkXVAuOyEQvF2=	NFH6W4o4OiCq		MmHwbY5lfWOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh[XW2b4DoZYd6	Ml7XNlAxOjh6NUS=
A549	NW\GO2I2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MkHSNE0{KM7:TR?=	NV:3eYpOPzJiaB?=		NUjXb2ExcW6mdXPld{Boem:5dHigbY5pcWKrdHnvckBidmRiYYX0c5Bp[We7	Ml2yNlAxOjh6NUS=

... Click to View More Cell Line Experimental Data

In vivo

AZD8055 inhibits the pS6 and pAkt in U87MG and A549 xenografts at 2.5/10 mg/kg, which leads to tumor growth inhibition. AZD8055 shows significant antitumor activity in many xenografts, including U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA at a dose of 10/20 mg/kg. ^[1] AZD8055 induces ~40% reduction in tumour volume, accompanied by ablation of phosphorylation of Akt, S6K and SGK protein kinases. Administration of AZD8055 (5mg/kg, Bid) and SAHA (100 mg/kg/d) results in complete tumor growth inhibition in PTEN+/−LKB1+/hypo xenografts without side effects on mice by inhibition of mTORC1 and mTORC2 signaling. ^[4]

Protocol

Kinase Assay:^[1]	+ Expand Cell-based determinations of mTOR inhibition: A high-throughput screening cell-based assay is developed using MDA-MB-468 cells to detect mTORC1 and mTORC2 activity. Cells are exposed for 2 hours to increasing concentrations of AZD8055. At the end of the incubation period, cells are fixed, washed, and probed with antibodies against S473 pAkt or against S235/236 phosphorylated S6 (pS6). Levels of phosphorylation are assessed using an Acumen laser scanning cytometer.
Cell Research:^[1]	+ Expand Cell lines: U87MG, A549 and H838 cells Concentrations: 1 nM - 1 μM Incubation Time: 72 to 96 hours Method: Cells are exposed to AZD8055 for 72 to 96 hours and stained for cell nuclei (0.03 mg/mL Hoechst 33342) and acidic vesicles (1 μg/mL acridine orange). Images are captured at 450 and 536 nm on an ArrayScan II platform, and the percentage of acidic vesicles and the number of cells are quantified. For LC3 assessment, cells are exposed to e64d/pepstatin (10 μg/mL) for 30 to 90 min before incubation with AZD8055. Cells are lysed on ice and analyzed by immunoblotting. (Only for Reference)
Animal Research:^[1]	+ Expand Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG and A549 are established in pathogen-free, female nude mice (nu/nu:Alpk). Formulation: Dissolved in captisol (CyDex, pH 3.0) and diluted to a final captisol concentration of 30% (w/v) Dosages: 2.5-20 mg/kg Administration: Oral gavage once or twice daily (Only for Reference)

References

[4] García-Martínez JM, et al. Br J Cancer, 2011, 104(7), 1116-1

+ Expand

Solubility (25°C)

In vitro	DMSO	50 mg/mL warmed (107.4 mM)
	Ethanol	3 mg/mL (6.44 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 4% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download AZD8055 SDF

Molecular Weight	465.54
Formula	C₂₅H₃₁N₅O₄
CAS No.	1009298-09-2
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
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Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-10-19)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01316809	Completed	Glioblastoma Multiforme\|Anaplastic Astrocytoma\|Anaplastic Oligodendroglioma\|Malignant Glioma\|Brainstem Glioma	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	March 4 2011	Phase 1
NCT00973076	Completed	Cancer\|Solid Tumors\|Advanced Solid Malignancies	AstraZeneca	August 2009	Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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mTOR Signaling Pathway Map

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AZD8055

Cited by 38 Publications

8 Customer Reviews

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Protocol

References

Solubility (25°C)

Chemical Information Download AZD8055 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-10-19)

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mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

Related mTOR Products

Choose Your Country or Region

By Signaling Pathways

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AZD8055

Cited by 38 Publications

8 Customer Reviews

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download AZD8055 SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2018-10-19)

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Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)