AZD8055

Catalog No.S1555

Molecular Weight(MW): 465.54

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

Cited by 70 Publications

Nature, 2019, 10.1038/s41586-019-1607-3

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Cancer Cell, 2017, 31(5):635-652

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Nat Med, 2015, 10.1038/nm.3855

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Cancer Cell, 2015, 27(1):97-108

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Sci Rep, 2019, 9(1):30

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Front Physiol, 2019, 10:167

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Acta Pharmacol Sin, 2018, 39(8):1338-1346

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Med Sci Monit, 2018, 24:2735-2743

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Cell Commun Signal, 2017, 10.1186/s12964-017-0164-3

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Biochim Biophys Acta Mol Cell Res, 2017, 1864(10):1554-1565

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Genome Biol, 2016, 17(1):149

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J Biol Chem, 2016, 291(12):6262-71

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Front Plant Sci, 2016, 7:1746

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Cell Signal, 2016, 28(4):284-93

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PLoS One, 2016, 11(4):e0154564

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Biochem Biophys Res Commun, 2016, 478(4):1515-20

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Int J Endocrinol, 2016, 2016:5286972

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J Biol Chem, 2015, 10.1074/jbc.C114.627778

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J Chromatogr A, 2015, 1388:267-73

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Proteomics, 2015, 10.1002/pmic.201400586

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J Clin Invest, 2014, 10.1172/JCI73935

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Oncotarget, 2014, 5(21):10732-44

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J Biol Chem, 2013, 288(49):35287-96

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Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Description

AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. Phase 1.

Features

First drug to inhibit both types of mTOR protein.

Targets

mTOR (truncated) ^[1] (MDA-MB-468 cells)	mTOR (full length) ^[1] (MDA-MB-468 cells)
0.13 nM	0.8 nM

In vitro

AZD8055 shows low activity (∼1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells. ^[1] AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. ^[2] AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7 nM and induces significant differences in EFS distribution. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
LU-139	MnLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1\hPGlEPTB;MD6wNlM{OSEQvF2=	M2DZ[3NCVkeHUh?=
NCI-H720	MkT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkTsTWM2OD1yLkCyPVM5KM7:TR?=	MXfTRW5ITVJ?
KARPAS-45	MoHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoXuTWM2OD1yLkCzN\|cyKM7:TR?=	NV\GVlh4W0GQR1XS
EW-3	M3n3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn[1TWM2OD1yLkC0NFU3KM7:TR?=	MXzTRW5ITVJ?
SBC-1	NV7J[nk6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3LvO2lEPTB;MD6wOFU5OSEQvF2=	MnryV2FPT0WU
NCI-H209	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NETpVVlKSzVyPUCuNFU1PTNizszN	M1\hdHNCVkeHUh?=
EoL-1-cell	NGDOTYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWHJR\|UxRTBwME[1Olkh\|ryP	NE[3XIpUSU6JRWK=
H9	Mlf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVfJR\|UxRTBwME[2PVIh\|ryP	NUTuXnhOW0GQR1XS
AN3-CA	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NITLellKSzVyPUCuNFc6PTFizszN	NHvUfVZUSU6JRWK=
HH	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYXyOJBqUUN3ME2wMlA5ODB7IN88US=>	NXrlVFVHW0GQR1XS
KU812	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlXaTWM2OD1yLkC4NFQ{KM7:TR?=	NXzORolEW0GQR1XS
DU-4475	M1vwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3;VNmlEPTB;MD6wPFA1PyEQvF2=	Mn;nV2FPT0WU
CTV-1	NHTnZ4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnK5TWM2OD1yLkC4OlQyKM7:TR?=	M{\tNHNCVkeHUh?=
BV-173	MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWjJR\|UxRTBwMEmwOlEh\|ryP	NHHH[4dUSU6JRWK=
ES5	M3vkOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX23VVkyUUN3ME2wMlA6OzVizszN	M2PUVHNCVkeHUh?=
G-402	NUXFdJMzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1vJWWlEPTB;MD6wPVk5KM7:TR?=	MmnIV2FPT0WU
MV-4-11	NEiyfZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1yzW2lEPTB;MD6xNFM1PyEQvF2=	NGDKb45USU6JRWK=
NB69	Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1rETGlEPTB;MD6xN\|Uh\|ryP	MYDTRW5ITVJ?
EGI-1	NX:0V5l1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUDTZWM{UUN3ME2wMlE{PTNzIN88US=>	NYrLVI5vW0GQR1XS
EW-18	NVLvcolHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX7JR\|UxRTBwMUSwO\|Mh\|ryP	NWfM[\|BQW0GQR1XS
ME-180	NY\5VXZVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MULJR\|UxRTBwMUS2PFEh\|ryP	MVPTRW5ITVJ?
D-283MED	MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn7YTWM2OD1yLkG0O\|I{KM7:TR?=	MmX5V2FPT0WU
NB14	NGn4N3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlXoTWM2OD1yLkG2OFQ4KM7:TR?=	M2XOfnNCVkeHUh?=
Ramos-2G6-4C10	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVjodoV[UUN3ME2wMlE3QTh\|IN88US=>	MlXzV2FPT0WU
NBsusSR	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX3JR\|UxRTBwMUewNVkh\|ryP	MmfUV2FPT0WU
LAMA-84	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlHTTWM2OD1yLkG4NFMzKM7:TR?=	NFnZU\|RUSU6JRWK=
NCI-H1581	MkK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnzLTWM2OD1yLkG4PVY3KM7:TR?=	NWH5fHdLW0GQR1XS
A204	NXz1SXpFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUjjNoROUUN3ME2wMlE5QTdizszN	M1vzenNCVkeHUh?=
A549	NYPVRpdIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2fiR2lEPTB;MD6xPVU2KM7:TR?=	Mn;WV2FPT0WU
CAL-51	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHTRS3BKSzVyPUCuNVk3PTFizszN	NV[5c\|hDW0GQR1XS
NKM-1	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXXwOZNyUUN3ME2wMlIxODJ7IN88US=>	NWTtOY1IW0GQR1XS
LoVo	M{\KfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mly5TWM2OD1yLkKwNlAzKM7:TR?=	MYDTRW5ITVJ?
HAL-01	MlTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2OyXWlEPTB;MD6yNFI6PyEQvF2=	M1WyfXNCVkeHUh?=
HCC2218	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3y2U2lEPTB;MD6yNFY5QCEQvF2=	M{L3OHNCVkeHUh?=
BEN	M3fwUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUnRe2xsUUN3ME2wMlIyOjl\|IN88US=>	MmfjV2FPT0WU
LC-2-ad	NELDbHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYrYe5h4UUN3ME2wMlIzODh2IN88US=>	NU[4PIV{W0GQR1XS
LXF-289	NUjWS5NoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4i5VWlEPTB;MD6yOVA1OSEQvF2=	MnnRV2FPT0WU
HGC-27	NYLBfY9TT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkjQTWM2OD1yLkK2OFE1KM7:TR?=	MXvTRW5ITVJ?
LK-2	NGX0PW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnG2TWM2OD1yLkK2PFI1KM7:TR?=	NYHiblViW0GQR1XS
CTB-1	MnzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mnm4TWM2OD1yLkK3NlE2KM7:TR?=	Mk\2V2FPT0WU
697	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX3EXm1[UUN3ME2wMlI4OzZ5IN88US=>	M1P4fXNCVkeHUh?=
ES7	M2HBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1rjRWlEPTB;MD6yO\|M5OyEQvF2=	M1TucnNCVkeHUh?=
MG-63	MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUHJR\|UxRTBwMke0NFch\|ryP	NGLzXWxUSU6JRWK=
T47D	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEj1RoVKSzVyPUCuNlc1PzVizszN	MVjTRW5ITVJ?
RPMI-8226	Ml7nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4DQPWlEPTB;MD6yPFU5QSEQvF2=	Mmn4V2FPT0WU
NCI-H292	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnrETWM2OD1yLkK5NVY1KM7:TR?=	M1zh[XNCVkeHUh?=
HT	M2rKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXTHe21WUUN3ME2wMlI6OzhizszN	MWHTRW5ITVJ?
A3-KAW	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlXuTWM2OD1yLkK5O\|Qh\|ryP	MkLKV2FPT0WU
LB2241-RCC	NGHxdIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NI\XW4tKSzVyPUCuN\|AyQThizszN	NVfw[Ws5W0GQR1XS
BB65-RCC	NF\ONYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2\YRWlEPTB;MD6zNFgxPSEQvF2=	NVTqO4U2W0GQR1XS
G-401	NYrEdIF6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGPlO2ZKSzVyPUCuN\|A6QDZizszN	M4DPOHNCVkeHUh?=
TYK-nu	MlvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MULJR\|UxRTBwM{G4OlQh\|ryP	MVzTRW5ITVJ?
NCI-SNU-1	MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF3zS2ZKSzVyPUCuN\|I{OzFizszN	MnjYV2FPT0WU
CHL-1	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3TEUWlEPTB;MD6zNlcxOyEQvF2=	NFmzdVVUSU6JRWK=
P30-OHK	MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVLJR\|UxRTBwM{K3NFUh\|ryP	MYDTRW5ITVJ?
PA-1	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml7kTWM2OD1yLkOzOlE6KM7:TR?=	MVjTRW5ITVJ?
LB1047-RCC	NIW2b2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXHkWZhHUUN3ME2wMlM1ODR5IN88US=>	M4Xrc3NCVkeHUh?=
EM-2	NVnpSldFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWWxeJJ[UUN3ME2wMlM1OTh6IN88US=>	MVXTRW5ITVJ?
VA-ES-BJ	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFPYTZVKSzVyPUCuN\|QzPjhizszN	NX[ySpR4W0GQR1XS
NCI-H520	M4TE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVH1bGlOUUN3ME2wMlM1QDN2IN88US=>	M3jseXNCVkeHUh?=
ECC10	MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnTsTWM2OD1yLkO1NFM2KM7:TR?=	NIPCeo5USU6JRWK=
LNCaP-Clone-FGC	NGPxd\|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mme4TWM2OD1yLkO1N\|E1KM7:TR?=	NV6yb3I3W0GQR1XS
ES8	NILESlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NW[4RWFmUUN3ME2wMlM3PTV\|IN88US=>	MV\TRW5ITVJ?
HuO-3N1	NUO3UnQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYD2UXN[UUN3ME2wMlM5Ozd7IN88US=>	NF;PfIhUSU6JRWK=
L-363	NEL5[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEXYVW9KSzVyPUCuN\|kxOjZizszN	NILM[YpUSU6JRWK=
SK-LU-1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYjJR\|UxRTBwM{myNFgh\|ryP	NFTvU4VUSU6JRWK=
MCF7	MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVPXXGJ5UUN3ME2wMlQxPTNizszN	MWDTRW5ITVJ?
HuO9	MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlnsTWM2OD1yLkSwOlY4KM7:TR?=	Ml7aV2FPT0WU
BHT-101	NV\5e2MyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVvJR\|UxRTBwNEC3PFch\|ryP	MUPTRW5ITVJ?
MZ2-MEL	NILsZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnLxTWM2OD1yLkSwPFgzKM7:TR?=	M1Pk[XNCVkeHUh?=
NOS-1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUXJR\|UxRTBwNEGwO\|Qh\|ryP	Mnu5V2FPT0WU
NEC8	M2m5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYPJR\|UxRTBwNEG2PVUh\|ryP	MoP3V2FPT0WU
COR-L88	Mn\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYrJR\|UxRTBwNEKyOlch\|ryP	NXrqdlR4W0GQR1XS
MFM-223	NGDx[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnH3TWM2OD1yLkSyOlE4KM7:TR?=	NYfHNmgyW0GQR1XS
HSC-3	NGnPV\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXrJR\|UxRTBwNEK5NFgh\|ryP	Mmq2V2FPT0WU
OVCAR-5	MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3[2WGlEPTB;MD60Nlk{OyEQvF2=	NGTlRo5USU6JRWK=
MFE-280	MonWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NU\2c4hKUUN3ME2wMlQ{ODN{IN88US=>	NUXkNIM3W0GQR1XS
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MDA-MB-157	M1ryS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV7JR\|UxRTBwNke4NUDPxE1?	M3uzbHNCVkeHUh?=
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RPMI-7951	Ml3mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NU[wVoZGUUN3ME2wMlc{PTN\|IN88US=>	Mm\RV2FPT0WU
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NCI-H747	NGDTTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXLJR\|UxRTBwN{W5PVEh\|ryP	MnTBV2FPT0WU
NCI-H1623	M4rOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmXnTWM2OD1yLke2NlYyKM7:TR?=	NV7ofYk4W0GQR1XS
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CAL-62	M4\HV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkTETWM2OD1yLke5PVI1KM7:TR?=	NVW2fYZkW0GQR1XS
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NCI-H1299	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXXJR\|UxRTFwNUCwPFYh\|ryP	NUC5cI9RW0GQR1XS
RO82-W-1	NV:yU2o{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUfJR\|UxRTFwNUKwPFEh\|ryP	NH;JellUSU6JRWK=
Becker	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3z1bWlEPTB;MT61NlE5PyEQvF2=	NUXsUodXW0GQR1XS
SNU-387	NXXCelZDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUDJR\|UxRTFwNUKyOFEh\|ryP	MkTTV2FPT0WU
CAL-85-1	Mne4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlXuTWM2OD1zLkWyOVk6KM7:TR?=	M4CxSnNCVkeHUh?=
647-V	NEPzbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYPONI05UUN3ME2xMlU{QDhizszN	MX;TRW5ITVJ?
SBC-5	M4\LU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVrJR\|UxRTFwNUS1PVMh\|ryP	M33DVXNCVkeHUh?=
NCI-H23	NYW5dJJjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2PtUWlEPTB;MT61OVcyPCEQvF2=	MkPBV2FPT0WU
CGTH-W-1	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{LhXWlEPTB;MT61OVgyQSEQvF2=	M1XQUHNCVkeHUh?=
SK-N-FI	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUDJR\|UxRTFwNUW5NFgh\|ryP	MWPTRW5ITVJ?
KM-H2	NVX6[\|NrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUP6XFlmUUN3ME2xMlU3PDd2IN88US=>	MoTrV2FPT0WU
KY821	NYTFXZV[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NW[3Xmg2UUN3ME2xMlU3PjF5IN88US=>	MYDTRW5ITVJ?
RH-1	MnPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1vENGlEPTB;MT61Olc3OiEQvF2=	Mlz6V2FPT0WU
KYSE-270	M4jNXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1fhRWlEPTB;MT61O\|QzOyEQvF2=	NIPuUJdUSU6JRWK=
SF539	M2D4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml7rTWM2OD1zLkW3PVY6KM7:TR?=	NXG1XXdNW0GQR1XS
JEG-3	NVvJU\|FET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGq0dlZKSzVyPUGuOVgxQTRizszN	Mmr3V2FPT0WU
SCC-25	M1LVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUHIXIdLUUN3ME2xMlU5PDN{IN88US=>	NIL4TYtUSU6JRWK=
SW1573	M2qzeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVT1dZg2UUN3ME2xMlYxOTV6IN88US=>	MnLaV2FPT0WU
EW-1	M4LVXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnLrTWM2OD1zLk[xN\|UyKM7:TR?=	NFzROm1USU6JRWK=
YKG-1	M2fhemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1PmTWlEPTB;MT62NVQ{QCEQvF2=	MW\TRW5ITVJ?
EW-11	NVH0SJhJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYjGPGY1UUN3ME2xMlYyPzRzIN88US=>	M{CzfXNCVkeHUh?=
DJM-1	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVHJR\|UxRTFwNkG4NlUh\|ryP	MkH4V2FPT0WU
Calu-3	NV\xOGJpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mk\uTWM2OD1zLk[1NlE{KM7:TR?=	NUnnW2h7W0GQR1XS
HT-3	M{Kwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFnRc4ZKSzVyPUGuOlU3PiEQvF2=	M1njenNCVkeHUh?=
NCI-H69	M4Lyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTFwNkezOFMh\|ryP	MVXTRW5ITVJ?
NCI-H2126	NHzSZ\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGHXb5VKSzVyPUGuOlc4QTdizszN	M4ryTnNCVkeHUh?=
RPMI-2650	NWDnZ4FzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnXXTWM2OD1zLk[4N\|E4KM7:TR?=	NE[xeXJUSU6JRWK=
TE-6	NWDhemFTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVLDdoNkUUN3ME2xMlcxQDd2IN88US=>	MVXTRW5ITVJ?
MDA-MB-231	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGnkXWFKSzVyPUGuO\|E6QTNizszN	NILYNWpUSU6JRWK=
A2780	NVP2UY5YT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4ThRmlEPTB;MT63NlIxPyEQvF2=	MmDJV2FPT0WU
GOTO	NIL0[\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWDySmpuUUN3ME2xMlc{PTZizszN	M2\WfXNCVkeHUh?=
KYSE-70	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXrDcJliUUN3ME2xMlc1PDR{IN88US=>	NFH6dYRUSU6JRWK=
GMS-10	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXHPUZpiUUN3ME2xMlc1PjZ{IN88US=>	MmDOV2FPT0WU
CaR-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWDLO5VWUUN3ME2xMlc1QDF{IN88US=>	NIfFV45USU6JRWK=
SW900	NEj0cXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2DycWlEPTB;MT63OFk6OyEQvF2=	MUfTRW5ITVJ?
BB49-HNC	M4jVNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWnCVXc4UUN3ME2xMlc2OTZ6IN88US=>	M3\KZnNCVkeHUh?=
SNB75	Ml;QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mmq2TWM2OD1zLke1OFkzKM7:TR?=	M2OzbnNCVkeHUh?=
SK-PN-DW	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NW[2b2pFUUN3ME2xMlc2Pjh{IN88US=>	NIOwcldUSU6JRWK=
5637	NV7rd3FoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVjJR\|UxRTFwN{eyOlgh\|ryP	M33OOnNCVkeHUh?=
BT-474	M1:zXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NE[3VpFKSzVyPUGuO\|gyPzFizszN	NW\JdlBtW0GQR1XS
KM12	NI\ETHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3LDN2lEPTB;MT63PVc1OSEQvF2=	NEHlbldUSU6JRWK=
COLO-680N	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXTy[XU1UUN3ME2xMlgzOzhzIN88US=>	Mmr2V2FPT0WU
Saos-2	NYOwOYNIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkW1TWM2OD1zLkiyOFQ2KM7:TR?=	M4rieXNCVkeHUh?=
CAL-54	MnmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGf6cGRKSzVyPUGuPFM{OTNizszN	MojZV2FPT0WU
U-118-MG	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlLuTWM2OD1zLki0OlIzKM7:TR?=	M1P6XXNCVkeHUh?=
TGBC24TKB	M3ri[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1nVWWlEPTB;MT64OVUxOSEQvF2=	NG\lOmZUSU6JRWK=
NCI-H2052	NHz6cnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEH6ZZdKSzVyPUGuPFY1OSEQvF2=	MlP4V2FPT0WU
BB30-HNC	NYHVT2FWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIXyW29KSzVyPUGuPFY1PjJizszN	MYDTRW5ITVJ?
KNS-81-FD	M1T0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnvwTWM2OD1zLki5NVY2KM7:TR?=	MY\TRW5ITVJ?
HN	MknuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn;BTWM2OD1zLki5OVQ2KM7:TR?=	NWnEOoNGW0GQR1XS
ACHN	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUH5eJN6UUN3ME2xMlkxPzh4IN88US=>	MUHTRW5ITVJ?
HSC-2	MlH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIHEdYVKSzVyPUGuPVExQTZizszN	NFfWe29USU6JRWK=
HCC2998	NEP1S3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn7aTWM2OD1zLkmzN\|I2KM7:TR?=	M17QNHNCVkeHUh?=
HEL	MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkLvTWM2OD1zLkm0NVg1KM7:TR?=	M1rrd3NCVkeHUh?=
SW684	NETJPZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoWyTWM2OD1zLkm3N\|cyKM7:TR?=	M3zZdXNCVkeHUh?=
NCI-H1693	Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVfj[Zh{UUN3ME2xMlk5ODh4IN88US=>	M2XaRnNCVkeHUh?=
8-MG-BA	NFz2dGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXzJR\|UxRTFwOUiyNUDPxE1?	M3nyV3NCVkeHUh?=
OVCAR-8	MmDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHrQSoNKSzVyPUKuNFAzQTVizszN	MkOwV2FPT0WU
DSH1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGXjeopKSzVyPUKuNFE4PzRizszN	MnHhV2FPT0WU
KYSE-520	MkLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUf2NWR5UUN3ME2yMlAzODR7IN88US=>	NIDHNXNUSU6JRWK=
GB-1	NHewfnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIHGZ4JKSzVyPUKuNFI2PzdizszN	NH76RmlUSU6JRWK=
RCC10RGB	MnHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVPJR\|UxRTJwMES4O\|Eh\|ryP	NWTMSYY5W0GQR1XS
SW954	M2XJe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmTzTWM2OD1{LkC1NFM3KM7:TR?=	M{XSRXNCVkeHUh?=
IST-MES1	NVLaeHpjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYTNOVhEUUN3ME2yMlA2PTZ6IN88US=>	M2HOZXNCVkeHUh?=
AU565	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlTrTWM2OD1{LkC1PVA2KM7:TR?=	M{\NVnNCVkeHUh?=
CW-2	NGXObFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXzJR\|UxRTJwME[4O\|Uh\|ryP	NFHLS3pUSU6JRWK=
TE-1	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWXJR\|UxRTJwMEmzO\|ch\|ryP	NUDxd5N{W0GQR1XS
KP-4	M33J[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2P4OGlEPTB;Mj6xNFMyOiEQvF2=	MnHVV2FPT0WU
SNU-C2B	NXPmZ4g4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1\KV2lEPTB;Mj6xNFgzOyEQvF2=	MUXTRW5ITVJ?
NCI-H1395	MnXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEnsWmdKSzVyPUKuNVA6QDZizszN	MlPYV2FPT0WU
CAS-1	NUTKXHdXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGK4U2tKSzVyPUKuNVE2PDZizszN	Mn35V2FPT0WU
NCI-H1155	NWLQdItYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmDuTWM2OD1{LkKyOlkh\|ryP	NXvQdYdZW0GQR1XS
SK-MEL-1	NXrnT2lYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3voNWlEPTB;Mj6yPFE5OSEQvF2=	NHXRS5lUSU6JRWK=
KINGS-1	MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4X4b2lEPTB;Mj6zNFA5QCEQvF2=	NWGyVJBTW0GQR1XS
ESS-1	NV2wXW5PT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3zwemlEPTB;Mj6zNFUyKM7:TR?=	MkThV2FPT0WU
PANC-10-05	M4f4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGC5[o5KSzVyPUKuN\|cxOjRizszN	NGLjfpRUSU6JRWK=
HT-1376	M3PBTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1TCVmlEPTB;Mj6zPFcxQCEQvF2=	MoXiV2FPT0WU
LS-513	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVP5T5hRUUN3ME2yMlM5QDd2IN88US=>	NVXpfVk3W0GQR1XS
KNS-42	NWXoV41WT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2HNOGlEPTB;Mj6zPVExPSEQvF2=	NVq4PGxrW0GQR1XS
639-V	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2jOdGlEPTB;Mj60Nlc2QCEQvF2=	NG\DWHpUSU6JRWK=
SJRH30	M4rhNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4XFNWlEPTB;Mj60OVE3OSEQvF2=	M3LWRXNCVkeHUh?=
SW1783	NV:xWY5yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoDSTWM2OD1{LkS3NFc5KM7:TR?=	MXLTRW5ITVJ?
NB6	NF3GeJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnvQTWM2OD1{LkS4Nlgh\|ryP	NH7s[\|JUSU6JRWK=
SK-MEL-30	M{D6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmHWTWM2OD1{LkS4PFMh\|ryP	MnL5V2FPT0WU
HCE-4	M3i4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFX0R5NKSzVyPUKuOFk1ODJizszN	M2\KTHNCVkeHUh?=
NB10	NWTPS4RnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1HCcmlEPTB;Mj60PVQzQSEQvF2=	MWHTRW5ITVJ?
H-EMC-SS	NGjCOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV3JR\|UxRTJwNUS2OUDPxE1?	NX;TVVJ4W0GQR1XS
SK-HEP-1	M4[2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF;RNIlKSzVyPUKuOVUzOzZizszN	NGjiSWdUSU6JRWK=
HCC1395	NGO1Zo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXPJR\|UxRTJwNUW2OVUh\|ryP	MYHTRW5ITVJ?
HuCCT1	M3H4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoTZTWM2OD1{LkW2N\|kh\|ryP	NIjWU\|VUSU6JRWK=
SiHa	NV7BU2ptT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUXBNY41UUN3ME2yMlU5PzF7IN88US=>	M4jBWHNCVkeHUh?=
EFO-21	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mm\5TWM2OD1{LkW4O\|Y1KM7:TR?=	NG\pVolUSU6JRWK=
NCI-H1666	M3LIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkTwTWM2OD1{LkW5NFc3KM7:TR?=	Mn7CV2FPT0WU
UMC-11	Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4Plb2lEPTB;Mj61PVg3QCEQvF2=	Mn[zV2FPT0WU
COLO-679	M1y4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXHyNVVNUUN3ME2yMlYyOjN\|IN88US=>	NH\qSGlUSU6JRWK=
A388	M3TLO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXzJR\|UxRTJwNkWyOVMh\|ryP	Ml;WV2FPT0WU
LB2518-MEL	MnXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkWwTWM2OD1{Lk[1OFA5KM7:TR?=	MmqxV2FPT0WU
EW-13	Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnPRTWM2OD1{Lk[4O\|Y5KM7:TR?=	MVTTRW5ITVJ?
MLMA	MoLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MonrTWM2OD1{Lk[4PFU3KM7:TR?=	M3m0dnNCVkeHUh?=
HOP-92	NYnJS\|E{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEnrTpRKSzVyPUKuO\|AyOSEQvF2=	MX3TRW5ITVJ?
NOMO-1	MmXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUfJR\|UxRTJwN{G0OFIh\|ryP	MUPTRW5ITVJ?
NCI-H810	MkjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH3MNmlKSzVyPUKuO\|IyQThizszN	M1TPfnNCVkeHUh?=
769-P	NHHX[GFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoXxTWM2OD1{LkeyNlgh\|ryP	M1n4c3NCVkeHUh?=
SAS	NYizOJdHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUi1SoY{UUN3ME2yMlc3PSEQvF2=	M1;4NHNCVkeHUh?=
M059J	NXLJdI83T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mo[wTWM2OD1{Lke4N\|E5KM7:TR?=	M13lb3NCVkeHUh?=
RD	M4TmR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVjQTJVsUUN3ME2yMlc6PDdzIN88US=>	NXHEWHVkW0GQR1XS
GT3TKB	M1nZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHHmcpBKSzVyPUKuPFM1OzNizszN	NUjPRVg6W0GQR1XS
MZ7-mel	M1P4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWnJR\|UxRTJwOE[1NFIh\|ryP	MYLTRW5ITVJ?
KYSE-510	NUDsd4p3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWTJR\|UxRTJwOEm1NFQh\|ryP	NFnkT3lUSU6JRWK=
NCI-N87	M{fVT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUjJR\|UxRTJwOUG4NFch\|ryP	NVn6[XlrW0GQR1XS
MKN1	NV3hcoZOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmXQTWM2OD1\|LkCwNVY{KM7:TR?=	MlnsV2FPT0WU
NCI-H2170	M{\Rb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWjjVJNLUUN3ME2zMlAxPDVzIN88US=>	MmSzV2FPT0WU
OVCAR-3	NEnCNIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4q4b2lEPTB;Mz6wNlEyPSEQvF2=	NEfKbFRUSU6JRWK=
KLE	MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIPpOItKSzVyPUOuNFY5OTJizszN	NIfnPXdUSU6JRWK=
LB771-HNC	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnfCTWM2OD1\|LkC5N\|Q{KM7:TR?=	MkG2V2FPT0WU
MC116	NEnWVnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIDTNIdKSzVyPUOuNVEyOTJizszN	NI\x[5FUSU6JRWK=
SCC-9	M1TSd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M13SdGlEPTB;Mz6xNVM3PiEQvF2=	M2\CbXNCVkeHUh?=
U031	M{\rVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXTwR5ptUUN3ME2zMlEzPDJ\|IN88US=>	M{DFT3NCVkeHUh?=
LCLC-103H	MkHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWi1dY9rUUN3ME2zMlI{QDl2IN88US=>	NUezXJdNW0GQR1XS
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JVM-2	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MliyTWM2OD1\|LkOyNVY1KM7:TR?=	MmHPV2FPT0WU
UACC-257	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXjsZYRNUUN3ME2zMlQ3PDNzIN88US=>	NVG2WZM6W0GQR1XS
LB996-RCC	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWexVYdXUUN3ME2zMlQ3PTB{IN88US=>	M3jQT3NCVkeHUh?=
BT-549	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVTJR\|UxRTNwNUCyNFkh\|ryP	MYXTRW5ITVJ?
NCI-H526	M4i3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4LD[GlEPTB;Mz61OFE2QCEQvF2=	NHfYZZRUSU6JRWK=
RH-18	NI[zUJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWnJR\|UxRTNwNkG3PVgh\|ryP	NXXJWnJoW0GQR1XS
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SK-N-AS	Mnr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUDJR\|UxRTNwN{OyOFch\|ryP	MkfZV2FPT0WU
IGR-1	MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYLJR\|UxRTNwN{SyOFgh\|ryP	NHfPOnZUSU6JRWK=
NCI-H2291	M1mydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1jmfGlEPTB;Mz63OVM{PiEQvF2=	Mnu3V2FPT0WU
NCI-H441	NXzwcJRWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml25TWM2OD1\|LkiyOFM{KM7:TR?=	NGjYVWNUSU6JRWK=
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COLO-320-HSR	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYT3dFVXUUN3ME2zMlkyOjdzIN88US=>	Mo\NV2FPT0WU
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RERF-LC-MS	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MornTWM2OD1\|Lkm2OVI2KM7:TR?=	MYXTRW5ITVJ?
SF268	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGPHVVlKSzVyPUSuNVI5QDFizszN	NV3JWHR{W0GQR1XS
RMG-I	NGDI[oxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlfXTWM2OD12LkKxOFU1KM7:TR?=	M{fSRXNCVkeHUh?=
CFPAC-1	NVjIW3Q5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2m2SmlEPTB;ND6yNVY5PSEQvF2=	NUfoVWZIW0GQR1XS
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NCI-H2122	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYPJR\|UxRTRwM{C5N\|Eh\|ryP	NGDkV4hUSU6JRWK=
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CAL-72	NFHKPIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml\jTWM2OD12LkO1OFc4KM7:TR?=	M1r1O3NCVkeHUh?=
GP5d	MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX;JR\|UxRTRwNEGyPVgh\|ryP	NEfKd2ZUSU6JRWK=
UACC-62	MnTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXy1Upd7UUN3ME20MlQ3PTR3IN88US=>	MWXTRW5ITVJ?
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HCC1937	MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkXDTWM2OD12Lki1NVI2KM7:TR?=	MoTXV2FPT0WU
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FADU	NFfXenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIr3emhKSzVyPUWuNlc5OzdizszN	NEfU[\|JUSU6JRWK=
CAPAN-1	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn7zTWM2OD13LkO5OFMzKM7:TR?=	MVfTRW5ITVJ?
TGBC11TKB	M2fxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEP4WXVKSzVyPUWuOFU4QDZizszN	NIrYdXFUSU6JRWK=
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ONS-76	M4LDfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX;JR\|UxRTVwNUW4NFEh\|ryP	NUHGNYRzW0GQR1XS
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COLO-741	NVLZSIh7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2Oz[2lEPTB;NT63NVk6PSEQvF2=	M{jWNXNCVkeHUh?=
HT-29	MlXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUPMc5FPUUN3ME21MlgxPDd3IN88US=>	MULTRW5ITVJ?
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NCI-H630	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MULJR\|UxRTZwMUG0OFEh\|ryP	NVvBS2NtW0GQR1XS
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NCI-SNU-5	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFzDVW1KSzVyPU[uNlcyOThizszN	NVfYR2lZW0GQR1XS
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OCI-AML2	NVnQW2Q3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGXxTGJKSzVyPU[uOFU1PDVizszN	MU\TRW5ITVJ?
HCC2157	MmrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn;XTWM2OD14LkS1OlE3KM7:TR?=	MUnTRW5ITVJ?
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NCI-H1650	M1vaemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYrJRmhEUUN3ME22MlcxPTJ{IN88US=>	M2nNVnNCVkeHUh?=
DU-145	NIDKPG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWLHNGg1UUN3ME22Mlc4ODNizszN	M1rBRnNCVkeHUh?=
COLO-829	NWfGe\|dvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2TvRmlEPTB;Nj63O\|g4OyEQvF2=	MWrTRW5ITVJ?
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HCC1954	NI\NfHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWPJR\|UxRTdwNEixN\|Qh\|ryP	MXzTRW5ITVJ?
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Mo-T	Mm\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUHNdHlEUUN3ME23MlUyPDl6IN88US=>	M{K2SXNCVkeHUh?=
OE19	MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFz0cJNKSzVyPUeuOlU2ODNizszN	MVjTRW5ITVJ?
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NCI-H2342	NXHN[lA{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFuyVItKSzVyPUeuO\|E2OjFizszN	M{mweXNCVkeHUh?=
U-87-MG	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGOxOIZKSzVyPUiuNFM{OzRizszN	M1\3THNCVkeHUh?=
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HT-1197	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{DDZmlEPTB;OD6yOVkxPyEQvF2=	NFK1NWVUSU6JRWK=
ChaGo-K-1	M{PuU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2rPZWlEPTB;OD6zOFI1PSEQvF2=	MnuxV2FPT0WU
NCI-H226	NGfBd\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoLHTWM2OD16LkS0N\|MyKM7:TR?=	NIrBWodUSU6JRWK=
NCI-H2029	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXzZNJp7UUN3ME25MlA3PzV7IN88US=>	MnrGV2FPT0WU
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NCI-H1651	NETqT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYLPblBOUUN3ME2xNE4zOzJ4IN88US=>	M2LyXXNCVkeHUh?=
NCI-H727	NYXyVGNpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXjJR\|UxRTFyLkS0PVUh\|ryP	M1XvPXNCVkeHUh?=
NCI-H358	Mk\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M32x[GlEPTB;MUCuPFM3PSEQvF2=	M2LjbXNCVkeHUh?=
NCI-H2087	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnLaTWM2OD1zMT6wOFM1KM7:TR?=	NH3sUYxUSU6JRWK=
FTC-133	NVTqSYF5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4jKeGlEPTB;MUGuOFA2OSEQvF2=	MYrTRW5ITVJ?
LAN-6	M2XLUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1XJeWlEPTB;MUKuNVI1KM7:TR?=	NIXCSlBUSU6JRWK=
NCI-H1838	M4fFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlvrTWM2OD1zMj61NVUyKM7:TR?=	MknyV2FPT0WU
Calu-6	NYKxTVlLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoDvTWM2OD1zND6xNFIyKM7:TR?=	MnTTV2FPT0WU
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CAL-27	Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVX1fVZuUUN3ME2xOU4{QDR\|IN88US=>	MXfTRW5ITVJ?
NCI-H82	NHTUNmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1O4[GlEPTB;MUWuOVMzKM7:TR?=	M3PJfnNCVkeHUh?=
no-10	M4iydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYHJR\|UxRTF3LkmzPEDPxE1?	M2PQNnNCVkeHUh?=
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COLO-824	NFvBPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVHJR\|UxRTJyLkmyO\|Yh\|ryP	NWDKPY9bW0GQR1XS
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L-428	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{i5ZWlEPTB;MkGuOFAyPiEQvF2=	MVrTRW5ITVJ?
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H196	MYjBdI9xfG:\|aYOgRZN{[Xl?	NIP4Unk2ODBibl2=	MlLKO\|IhcA>?		MlfKcohidmOnczDBRnQuOjZ\|4pETbY5lfWOnZDDhdI9xfG:\|aYO=	NWD6fI4zOjV5M{e1OFI>
H446	NFLBVpBCeG:ydH;zbZMhSXO\|YYm=	MYS1NFAhdk1?	NUnMT2dVPzJiaB?=		NF7rcndvcGGwY3XzJGFDXC1{NkRihLNqdmS3Y3XkJIFxd3C2b4Ppdy=>	MXWyOVc{PzV2Mh?=
TFK-1	NX;XcGg3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MYO3NkBp	MVrEUXNQ	MUnJR\|UxRTR5IH7N	NUnmbZZtOjVzNUKyOFQ>
EGI-1	NUnoPYtPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MXS3NkBp	M{TmUmROW09?	NYDVS\|kxUUN3ME21N{BvVQ>?	NVfvbW9COjVzNUKyOFQ>
OCI/AML3	M3ThTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MoP2NE4zKM7:TR?=	M3fmWlQ5KGh?		MmXr[Y5p[W6lZYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCrbnT1Z4VlKGK7IIPlcJVu\XSrbnni	NWC4SFZSOjR5M{mzPVM>
U937	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXqwMlIh\|ryP	M1\Qd\|Q5KGh?		MkjC[Y5p[W6lZYOgZ4VtdCCpcn;3eIghcW6qaXLpeIlwdiCrbnT1Z4VlKGK7IIPlcJVu\XSrbnni	NGfze3czPDd\|OUO5Ny=>
MOLM13	NYjwNpc{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlPENE4zKM7:TR?=	MnHYOFghcA>?		MVvlcohidmOnczDj[YxtKGe{b4f0bEBqdmirYnn0bY9vKGmwZIXj[YQh[nlic3XseY1mfGmwaXK=	MmnXNlQ4Ozl\|OUO=
MCF7	MmLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MWiyNEBvVQ>?	MUK3NkBp	NVfOZYNQTkKV	NGnPTHhz\WS3Y3XzJJRp\SCSRVzQNU1u\WSrYYTl[EBqdmO{ZXHz[UBqdiClZXzsJJZq[WKrbHn0fS=>	NUDQZ\|F[OjR4OEiwOFY>
TamR	NXfXZ29sT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NY[ySoNbUUN3ME2xPQKBkW6P	NU\JV3dGOjR2NUewOlk>
MCF7-X	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF\Cb3ZKSzVyPUK0JI5O	M32wXlI1PDV5ME[5
T47D-tamR	M3ixbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mmi4TWM2OD1zOTDuUS=>	MXeyOFQ2PzB4OR?=
293T	M4O2WWZ2dmO2aX;uJGF{e2G7	NEXCWlUzOCCwTR?=	NFrqcos{KGh?		NGLKdoFlcXO{dYD0d{BCc3RvbXXkbYF1\WRiVFnGMWlCKHO2YXLpcIl1gSxidILhcpNtd2OjdHnvckwh[W6mIHHjeIl3cXS7	M1rnN\|I1OzZ\|NES5
SW620	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlXWNE4xODFvMUFOwG0>	M3e3bFI1KGh?		NGLKZlJqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHHzJJRp\SClb37j[Y51emG2aX;uJJJqe2W\|	MVSyOFM3OzR2OR?=
Huh7	M2nH[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXi1MVExOCCwTR?=	MUewMVI1KGh?	NUXjPYs6TE2VTx?=	M2LMN4lv[3KnYYPld{Bk\WyuIHTlZZRpKGmwIHGgZ49v[2WwdILheIlwdi1iYX7kJJRqdWVvZHXw[Y5l\W62IH3hco5meg>?	MXqyOFI6PzNyMB?=
Hep3B	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4DOb\|UuOTByIH7N	M17NU\|AuOjRiaB?=	NFnqNVJFVVOR	NUnLelI3cW6lcnXhd4V{KGOnbHyg[IVifGhiaX6gZUBkd26lZX70doF1cW:wLTDhcoQhfGmvZT3k[ZBmdmSnboSgcYFvdmW{	NFzQVlkzPDJ7N{OwNC=>
Huh7	NXewcJVvTnWwY4Tpc44hSXO\|YYm=	NFz0ZpgyODBibl2=	NFTjWWkyOiCq	MljUSG1UVw>?	NEDpZplqdmS3Y3XzJIF2fG:yaHHnfeKh	M1;IdlI1Ojl5M{Cw
U87-MG	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NXPPWlY3PzJiaB?=		NWXFXIJpT0l3MPMAjV3jiIl5OTDuUeKh	MmHvNlQzPDl4NEC=
L3.6pl	NH;LTVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M{ewfVEh\|ryP	Mmn4O\|IhcA>?		MnvCbY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHPvcYJqdmWmIIfpeIghSk2VLUe3O\|YxPw>?	MUCyOFI{OzN7OR?=
TE671	M{H5emFxd3C2b4Ppd{BCe3OjeR?=	Mkn3NUDPxE1?	Moq0OFghcA>?		MUjpcoNz\WG\|ZYOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDBRnQuPzN5	NYXJbIRjOjRzM{OyNVg>
RD	NEezeVlCeG:ydH;zbZMhSXO\|YYm=	M4jxUFEh\|ryP	MnHuOFghcA>?		NWDaeZNIcW6lcnXhd4V{KGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhSUKWLUezOy=>	Mnq0NlQyOzN{MUi=
RMS13	NYK2NGRoSXCxcITvd4l{KEG\|c3H5	NH;acIsyKM7:TR?=	NUn1OGVqPDhiaB?=		NFryUHJqdmO{ZXHz[ZMh[2WubDDhdI9xfG:\|aYOgbY5lfWOnZDDifUBCSlRvN{O3	M4PiV\|I1OTN\|MkG4
RH30	MoTURZBweHSxc3nzJGF{e2G7	NWLzb2dUOSEQvF2=	NVfCelk2PDhiaB?=		M2rubYlv[3KnYYPld{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JGFDXC15M{e=	MlrDNlQyOzN{MUi=
Hep-2	NWHzRmZuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MYmwMlAyNTFizszN	Mn;NNVIuQTZiaB?=		MX\pcoNz\WG\|ZYOgZ4VtdCCmZXH0bEBqdiCjIHPvcoNmdnS{YYTpc44uKGGwZDD0bY1mNWSncHXu[IVvfCCvYX7u[ZI>	MlXwNlQyODN5NEm=
SCC-9	NXXpfYZDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NELuelgxNjBzLUGg{txO	NUPJZploOTJvOU[gbC=>		NXHtSXR3cW6lcnXhd4V{KGOnbHyg[IVifGhiaX6gZUBkd26lZX70doF1cW:wLTDhcoQhfGmvZT3k[ZBmdmSnboSgcYFvdmW{	NETYVnIzPDFyM{e0PS=>
Hep-2	MkTrSpVv[3Srb36gRZN{[Xl?	MXSwMlEwOC53IN88US=>	M2C1flI1KGh?		M4jOZ4Jtd2OtczDtWG9TSzFiYX7kJI1VV1KFMjDhZ5RqfmG2aX;u	M{D3PVI1OTB\|N{S5
SCC-9	M1rjO2Z2dmO2aX;uJGF{e2G7	NXLMe4UxOC5zL{CuOUDPxE1?	NXn5[XloOjRiaB?=		M4PHRYJtd2OtczDtWG9TSzFiYX7kJI1VV1KFMjDhZ5RqfmG2aX;u	NGm3SIEzPDFyM{e0PS=>
PANC-1	NVrpR\|ltSXCxcITvd4l{KEG\|c3H5	NG\4eYI2ODBibl2=	M4nGe\|Q5KGh?		NXvMc4VMe2Wwc3n0bZpmeyCyYX7jdoVifGmlIHPhcoNmeiClZXzsd{B1dyC{YXTpc5Rp\XKjcIm=	MVGyN\|g5PjJ7NB?=
RMG2	MknrRZBweHSxc3nzJGF{e2G7	NYfKbnJvOS1zMECwJI5O	MUS3NkBp	NGf1Z3hHSlN?	NWLmcphqcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGOxbnPlcpRz[XSrb36g[IVx\W6mZX70cJk>	M2TQR\|I{PjF3NkOx
HAC2	M{TvWWFxd3C2b4Ppd{BCe3OjeR?=	MoPHNU0yODByIH7N	NXTZOYxnPzJiaB?=	M4HsSWZDWw>?	NGHTWZBqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkh[2:wY3XueJJifGmxbjDk[ZBmdmSnboTsfS=>	Mn\ENlM3OTV4M{G=
HT-29	MWPBdI9xfG:\|aYOgRZN{[Xl?	MW[xJO69VQ>?	MnW1O\|IhcA>?		NWDSUJk2[XS2ZX71ZZRmeyB3LV\VMYlv\HWlZXSgZ4VtdCCmZXH0bC=>	NWT3ZZVZOjF7NEmxNlE>
DLD1	MYHBdI9xfG:\|aYOgRZN{[Xl?	NXrVU5d[OSEQvF2=	M1;vZVczKGh?		M3PXRYF1fGWwdXH0[ZMhPS2IVT3pcoR2[2WmIHPlcIwh\GWjdHi=	MVyyNVk1QTF{MR?=
HT-29	NULjbZYzTnWwY4Tpc44hSXO\|YYm=	MXuxJO69VQ>?	M2nj[lczKGh?		Mn3YbY5lfWOnczDheZRweGijZ4mgeI8h[2:wZnXyJIN6fG:ycn;0[YN1cW:w	M4HrOlIyQTR7MUKx
DLD1	NVy2R\|N[TnWwY4Tpc44hSXO\|YYm=	NVnYfXRDOSEQvF2=	MX:3NkBp		NE\GSYVqdmS3Y3XzJIF2fG:yaHHnfUB1dyClb37m[ZIh[3m2b4Dyc5Rm[3Srb36=	NF7rNowzOTl2OUGyNS=>
Rh41	NX:yOIVoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkHUTWM2OD1\|MD63JI5O	M2\SWFIyOzN5Nke5
Rh18	M2jNNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVrEb5lIUUN3ME20NU41KG6P	MVyyNVM{PzZ5OR?=
Rh30	NFLRbnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHizWYlKSzVyPUG0JI5O	MVeyNVM{PzZ5OR?=
BT-12	NUP2XItDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWDT[\|lZUUN3ME2yOE44KG6P	MUiyNVM{PzZ5OR?=
CHLA-266	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1m2Z2lEPTB;MT6xJI5O	MWqyNVM{PzZ5OR?=
TC-71	NEjwXGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUjWdmt4UUN3ME20Ok42KG6P	NXvhU\|RLOjF\|M{e2O\|k>
CHLA-9	NV;hU45IT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2XWTWlEPTB;MUWuN{BvVQ>?	MUWyNVM{PzZ5OR?=
CHLA-10	MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn3DTWM2OD1\|Lkmgcm0>	M{HablIyOzN5Nke5
CHLA-258	NFjQcYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MULJR\|UxRTFyLkSgcm0>	NEnpWFYzOTN\|N{[3PS=>
GBM2	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2nMbmlEPTB;NECuO{BvVQ>?	MVSyNVM{PzZ5OR?=
NB-1643	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXH6emRIUUN3ME2zN{45KG6P	NFLVS\|UzOTN\|N{[3PS=>
NB-EBc1	M{WxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2fBNWlEPTB;MkeuNUBvVQ>?	M2rLdlIyOzN5Nke5
CHLA-90	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NU\WWJM5UUN3ME2zOE42KG6P	NXvqd3BjOjF\|M{e2O\|k>
CHLA-136	M2rKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEjn[GJKSzVyPUG2Nk43KG6P	MkSwNlE{Ozd4N{m=
NALM-6	NF7DdWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{TnOWlEPTB;M{KuPUBvVQ>?	MUiyNVM{PzZ5OR?=
COG-LL-317	NIfvdIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUDndmF1UUN3ME2xMlMhdk1?	M2TV[FIyOzN5Nke5
RS4;11	MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MknxTWM2OD1\|NTDuUS=>	NUi3PFJIOjF\|M{e2O\|k>
MOLT-4	NGXKWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3PsdWlEPTB;OD62JI5O	MYWyNVM{PzZ5OR?=
CCRF-CEM	NXfwPJNXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mny5TWM2OD12LkGgcm0>	MWGyNVM{PzZ5OR?=
Kasumi-1	Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX;JR\|UxRTFwNDDuUS=>	NIXGZ\|kzOTN\|N{[3PS=>
Karpas-299	M2jCbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYjJR\|UxRTJzLkegcm0>	NF:4[JczOTN\|N{[3PS=>
Ramos-RA1	M2rKXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXXaNnRnUUN3ME24MlIhdk1?	MmDLNlE{Ozd4N{m=
H838	MX3GeY5kfGmxbjDBd5NigQ>?	NXrZXWJwOSEQvF2=	NVrIV3ZFPDhiaB?=		NGr6RnFqdmS3Y3XzJINmdGxiYYX0c5Bp[We7	Mk\BNlA{PjRzMUO=
H838	NVPaOnFvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlzyNE0{KM7:TR?=	NGmwVG44OiCq		NEXMfFdqdmS3Y3XzJIdzd3e2aDDpcohq[mm2aX;uJIFv\CCjdYTvdIhi\3l?	NXXMUIFLOjByMki4OVQ>
A549	NVHwfHJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MofMNE0{KM7:TR?=	MVu3NkBp		Mlf6bY5lfWOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh[XW2b4DoZYd6	M2nuSlIxODJ6OEW0

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	p-mTOR / p-AKT / p-4EBP1 / p-P70S6K / p-PRAS40; PubMed: 24457069 Breast Cancer Res Western blots of 70% confluent TamR (A) and MCF7-X (B) cells treated for 15 minutes to 24 hours with AZD8055 (0 to 100 nM). Blots were probed with phospho- and total antibodies for mTORC1 and two signalling pathways. In both cell lines mTORC1 and mTORC2 s䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙 p-EGFR / EGFR; PubMed: 25654224 Int J Mol Sci PANC-1 cells were treated with AZD8055 for the indicated hours and EGFR (T/P), AKT (T/P) and ribosomal protein S6 (S6) (T/P) proteins were examined by western-blot; p-FOXO1 / FOXO1 / p-FOXO3a / FOXO3a ; PubMed: 25654224 Int J Mol Sci PANC-1 cells were transfected with FoxO1/FoxO3a siRNAs and treated with AZD8055 for 1 h, then AKT (T/P), FoxO1 (T/P), FoxO3a (T/P) and EGFR (T/P) proteins were examined by western-blot.	24457069 25654224
Immunofluorescence	p-4EBP1 / EIF4E / mTOR; PubMed: 24600487 Int J Clin Exp Med (C) Hoechst 33258 staining of Hep-2 cells after treatment with AZD8055 for 24 hours were shown. The cells were fixed and immunereacted with anti-mTOR antibody followed by incubation with Alexa 488-labeled secondary antibody (C-F). Images were taken by a c䲧疝Ỵ疞㧀疜膉痘 瘿삨ՂᾰƌՂĀ 㺣痖帉痖Ѐ瑖堘𢡄빢᎒ՂĀ鑸᎒彿堙奋堙巫堙᎒ﻺ᎒彿堙ﻮ᎒塚堙ﻺ᎒ꍈ堞빢᎒學堙漸堞圔堙빢᎒圞堙圭堙𢡄玚Wᾰƌ ᾰƌ戤瘯Ɖ�෋䐺痖暼瘿�෋ᾰƌ �෋à㺣痖�෋𢡄�෋䀷痗�෋౴�෋㵶痗�෋뺖᎒泌Itemｾ᎒Count﫨呂�෋猴፲�෋፲씢痗猸፲髸莤䥷堙᎒ｾ᎒�堞ﻮ᎒፲露𢡄堚،齃礤v�堞ﻮ᎒猢Wｾ᎒䨼Ą鹿齃殺獸W戀醙玛W戀ⶰ໯齃礤v 玚W玢Wⶰ໯﫰礌vtЉᔈැ鲬౴᥊疜犈፲Eo狜፲艘ᎂ艘ᎂ⩈̎䥠̌씢痗狠፲붖᎒i變ﱘ﫰﬐먙堘붖᎒狠፲i變ﱘ﫰먰堘ﱘ붖᎒�堞봆᎒릎堘붖᎒i꣩쯟巰痗ꣵ쯟巰痗Љ镴౴嶴痗Љ镨౴ᔈැ竗ᔈැ屷痗W竗尊痗 LC3B / p62 ; PubMed: 30337536 Cell Death Dis Immunofluorescence staining of U87 and U251 GICs, which treated by DMSO, AZD8055 (0.3 μM) and rapamycin (3 μM). The nuclei were stained with DAPI and the antibody against LC3B and p62. Images were captured by laser confocal microscope ( × 400), scale bar 䲧疝Ỵ疞	24600487 30337536
Growth inhibition assay	Cell viability ; PubMed: 29263324 Nat Commun Growth for the indicated cell lines was assessed after 72 h of treatment with AZD8055 (0–250 nM). Results are expressed as a percentage of cell number relative to the DMSO-treated control cells a.	29263324

In vivo

AZD8055 inhibits the pS6 and pAkt in U87MG and A549 xenografts at 2.5/10 mg/kg, which leads to tumor growth inhibition. AZD8055 shows significant antitumor activity in many xenografts, including U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA at a dose of 10/20 mg/kg. ^[1] AZD8055 induces ~40% reduction in tumour volume, accompanied by ablation of phosphorylation of Akt, S6K and SGK protein kinases. Administration of AZD8055 (5mg/kg, Bid) and SAHA (100 mg/kg/d) results in complete tumor growth inhibition in PTEN+/−LKB1+/hypo xenografts without side effects on mice by inhibition of mTORC1 and mTORC2 signaling. ^[4]

Protocol

Kinase Assay:^[1]	+ Expand Cell-based determinations of mTOR inhibition: A high-throughput screening cell-based assay is developed using MDA-MB-468 cells to detect mTORC1 and mTORC2 activity. Cells are exposed for 2 hours to increasing concentrations of AZD8055. At the end of the incubation period, cells are fixed, washed, and probed with antibodies against S473 pAkt or against S235/236 phosphorylated S6 (pS6). Levels of phosphorylation are assessed using an Acumen laser scanning cytometer.
Cell Research:^[1]	+ Expand Cell lines: U87MG, A549 and H838 cells Concentrations: 1 nM - 1 μM Incubation Time: 72 to 96 hours Method: Cells are exposed to AZD8055 for 72 to 96 hours and stained for cell nuclei (0.03 mg/mL Hoechst 33342) and acidic vesicles (1 μg/mL acridine orange). Images are captured at 450 and 536 nm on an ArrayScan II platform, and the percentage of acidic vesicles and the number of cells are quantified. For LC3 assessment, cells are exposed to e64d/pepstatin (10 μg/mL) for 30 to 90 min before incubation with AZD8055. Cells are lysed on ice and analyzed by immunoblotting. (Only for Reference)
Animal Research:^[1]	+ Expand Animal Models: U87MG, BT474c, A549, Calu-3, LoVo, SW620, PC3 and MES-SA U87-MG and A549 are established in pathogen-free, female nude mice (nu/nu:Alpk). Formulation: Dissolved in captisol (CyDex, pH 3.0) and diluted to a final captisol concentration of 30% (w/v) Dosages: 2.5-20 mg/kg Administration: Oral gavage once or twice daily (Only for Reference)

References

[4] García-Martínez JM, et al. Br J Cancer, 2011, 104(7), 1116-1

+ Expand

Solubility (25°C)

In vitro	DMSO	50 mg/mL warmed (107.4 mM)
	Ethanol	3 mg/mL (6.44 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 4% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download AZD8055 SDF

Molecular Weight	465.54
Formula	C₂₅H₃₁N₅O₄
CAS No.	1009298-09-2
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

Selective mTOR inhibitor

Rapamycin (Sirolimus) : mTORC1-selective, IC50=~0.1 nM.
Most Potent mTOR Inhibitor

Rapamycin (Sirolimus) : mTOR, IC50=~0.1 nM.
FDA-approved mTOR Inhibitor

Temsirolimus (CCI-779, NSC 683864) : Approved by FDA for Renal Cell Carcinoma (RCC).
Newest mTOR Inhibitor

XL388 ^New : Highly potent, selective, ATP-competitive inhibitor of mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.

Related mTOR Products

MHY1485 ^New

MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.
CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.
Dorsomorphin (Compound C) ^New

Dorsomorphin is a potent, reversible, selective AMPK inhibitor with K_i of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type I BMP receptor activity.
Rapamycin (Sirolimus)

Rapamycin (Sirolimus) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.
Everolimus (RAD001)

Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay.
Torin 1

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.
Temsirolimus (CCI-779, NSC 683864)

Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay.
Sapanisertib (INK 128, MLN0128,TAK-228)

Sapanisertib (INK 128, MLN0128) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.
Tacrolimus (FK506)

Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.
KU-0063794

KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks.

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AZD8055

Cited by 70 Publications

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download AZD8055 SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

Related mTOR Products

Choose Your Country or Region

By Signaling Pathways

By product type

AZD8055

Cited by 70 Publications

Purity & Quality Control

Choose Selective mTOR Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download AZD8055 SDF

Bio Calculators

Molarity Calculator

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

mTOR Signaling Pathway Map

mTOR Inhibitors with Unique Features

Related mTOR Products

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)