Name: Avacopan (CCX168)
Brand: Selleck Chemicals
SKU: S0474
Availability: InStock
Rating: 5 (3 reviews)

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Quality Control

Batch: Purity: 99.04%

99.04

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
Other Complement System Inhibitors	Compstatin SB290157 trifluoroacetate TLQP-21 TFA Danicopan Phaseoloidin JR14a Pegcetacoplan acetate

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (171.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 17 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.600mg/ml (1.03mM)	Taking the 1 mL working solution as an example, add 50 μL of 12 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.600mg/ml (1.03mM)	Taking the 1 mL working solution as an example, add 50 μL of 12 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	581.64	Formula	C₃₃H₃₅F₄N₃O₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1346623-17-3	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	CCX168			SMILES	CC1=C(C(=CC=C1)F)C(=O)N2CCCC(C2C3=CC=C(C=C3)NC4CCCC4)C(=O)NC5=CC(=C(C=C5)C)C(F)(F)F

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	C5aR
In vitro	Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.
References	[1] https://pubmed.ncbi.nlm.nih.gov/28400446/ [2] https://pubmed.ncbi.nlm.nih.gov/35614037/ [3] https://pubmed.ncbi.nlm.nih.gov/24179165/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-14)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06072482	RECRUITING	Antineutrophil Cytoplasmic Antibody-associated Vasculitis	Amgen	2024-02-07	PHASE4
NCT07176546	RECRUITING	Granulomatosis With Polyangiitis; Wegener's; GPA	Robert Spiera, MD	2026-05-22	PHASE2; PHASE3
NCT07373262	NOT_YET_RECRUITING	ANCA-Associated Vasculitis (AAV)	University Hospital, Toulouse	2026-03-01	PHASE3
NCT06676579	RECRUITING	IgA Nephropathy (IgAN)	Mayo Clinic	2025-06-09	PHASE2
NCT07556484	RECRUITING	Diffuse Alveolar Hemorrhage; Antineutrophil Cytoplasmic Antibody Positive Vasculitis	Mayo Clinic	2026-08-01	PHASE1
NCT06321601	ACTIVE_NOT_RECRUITING	Vasculitis	Amgen	2024-10-22	PHASE3

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Avacopan (CCX168) C5aR Inhibitor

Chemical Structure

Molecular Weight: 581.64