Avacopan

Synonyms: CCX168

Avacopan is an orally administered and selective C5a receptor (C5aR) antagonist.

Avacopan Chemical Structure

Avacopan Chemical Structure

CAS: 1346623-17-3

Selleck's Avacopan has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.04%
99.04

Avacopan Related Products

Choose Selective Immunology & Inflammation related Inhibitors

Biological Activity

Description Avacopan is an orally administered and selective C5a receptor (C5aR) antagonist.
Targets
C5aR [1]
In vitro
In vitro

Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.

Cell Research Cell lines RAW 264.7 cells
Concentrations 1 µM
Incubation Time 24 h
Method

Cells were treated with indicated concentrations of drug for 24 h.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05897684 Recruiting
ANCA-associated Vasculitis
Vifor Fresenius Medical Care Renal Pharma
September 11 2023 --
NCT06004934 Completed
Hepatic Impairment
Amgen
April 17 2018 Phase 1
NCT05988008 Completed
Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis
Amgen
October 23 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 581.64 Formula

C33H35F4N3O2

CAS No. 1346623-17-3 SDF --
Smiles CC1=C(C(=CC=C1)F)C(=O)N2CCCC(C2C3=CC=C(C=C3)NC4CCCC4)C(=O)NC5=CC(=C(C=C5)C)C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (171.92 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 17 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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