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Ambroxol

Name: Ambroxol
Brand: Selleck Chemicals
SKU: S5710
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Catalog No.S5710

For research use only.

Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.

CAS No. 18683-91-5

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Biological Activity

Description	Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.

Protocol (from reference)

Solubility (25°C)

In vitro	DMSO	76 mg/mL (201.0 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight	378.10
Formula	C₁₃H₁₈Br₂N₂O
CAS No.	18683-91-5
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04405596	Not yet recruiting	Drug: Ambroxol Hydrochloride\|Other: Placebo	Lewy Body Disease	Lawson Health Research Institute	September 2020	Phase 1\|Phase 2
NCT04388969	Recruiting	--	Gaucher Disease\|Parkinson Disease\|GBA Gene Mutation	Shaare Zedek Medical Center	May 6 2020	--
NCT02941822	Completed	Drug: Ambroxol	Parkinson Disease	University College London\|The Cure Parkinson''s Trust	December 2016	Phase 2
NCT02914366	Recruiting	Drug: Ambroxol\|Other: Placebo	Parkinson''s Disease Dementia	Lawson Health Research Institute\|Weston Brain Institute\|University of Western Ontario Canada\|London Health Sciences Centre	November 2015	Phase 2
NCT02373891	Completed	Drug: Surfolase CR	Healthy Volunteers	Hyundai Pharmaceutical Co. LTD.	April 2014	Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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