Ajmaline

Catalog No.S5371 Synonyms: Cardiorythmine, Tachmalin

For research use only.

Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.

Ajmaline Chemical Structure

CAS No. 4360-12-7

Purity & Quality Control

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Biological Activity

Description Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 326.43
Formula

C20H26N2O2

CAS No. 4360-12-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1C2CC3C4C5(CC(C2C5O)N3C1O)C6=CC=CC=C6N4C

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04504591 Terminated -- Brugada Syndrome 1S Angelo Auricchio|Cardiocentro Ticino December 14 2017 --
NCT02933437 Unknown status Drug: Ajmaline Brugada Syndrome|Sudden Death St George''s University of London October 22 2017 Phase 2
NCT03106701 Recruiting Procedure: Ablation ECG Brugada Pattern IRCCS Policlinico S. Donato March 14 2017 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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