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Ajmaline Potassium Channel inhibitor

Cat.No.S5371

Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.
Ajmaline Potassium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 326.43

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Quality Control

Batch: S537101 DMSO]65 mg/mL]false]]]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 326.43 Formula

C20H26N2O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 4360-12-7 -- Storage of Stock Solutions

Synonyms Cardiorythmine, Tachmalin Smiles CCC1C2CC3C4C5(CC(C2C5O)N3C1O)C6=CC=CC=C6N4C

Solubility

In vitro
Batch:

DMSO : 65 mg/mL (199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04504591 Terminated
Brugada Syndrome 1S
Angelo Auricchio|Cardiocentro Ticino
 December 14 2017 --
NCT02933437 Unknown status
Brugada Syndrome|Sudden Death
St George''s University of London
 October 22 2017 Phase 2
NCT03106701 Recruiting
ECG Brugada Pattern
IRCCS Policlinico S. Donato
 March 14 2017 Not Applicable

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