AG-1478 (Tyrphostin AG-1478)

For research use only.

Catalog No.S2728 Synonyms: NSC 693255

66 publications

AG-1478 (Tyrphostin AG-1478) Chemical Structure

CAS No. 153436-53-4

AG-1478 (Tyrphostin AG-1478, NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA).

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Selleck's AG-1478 (Tyrphostin AG-1478) has been cited by 66 publications

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description AG-1478 (Tyrphostin AG-1478, NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA).
Targets
EGFR [1]
(Cell-free assay)
3 nM
In vitro

AG-1478 is high selective over ErbB2 and PDGFR with IC50 of >100 μM. [1] AG-1478 preferentially inhibits U87MG cells expressing truncated EGFR with IC50 of 8.7 μM, compared to those expressing endogenous wt EGFR or overexpressing exogenous wt EGFR with IC50 of 34.6 μM and 48.4 μM, respectively, and inhibits the DNA synthesis with IC50 of 4.6 μM, 19.67 μM, and 35.2 μM, respectively. AG-1478 also preferentially inhibits the tyrosine kinase activity and autophosphorylation of the ΔEGFR compared to endogenous or overexpressed exogenous wt EGFR. [2] AG-1478 (0.25 μM) abolishes the MAPK activation induced by Ang II, a Ca2+ ionophore as well as EGF but not by a phorbol ester or platelet-derived growth factor-BB in the VSMC. [3] AG-1478 inhibits EGF-induced mitogenesis of the BaF/ERX and LIM1215 cells with IC50 of 0.07 μM and 0.2 μM, respectively. [6] AG1478 is able to inhibit the function of ATP-binding cassette (ABC) transporters such as ABCB1 and ABCG2, with a more pronounced effect on ABCG2. [7]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U87MG NVnW[oZYT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NHf4dol,OTByIN88US=> MkTOSG1UVw>? MoPGTWM2OD1|ND62JO69VQ>? M2HrbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh5NUKxOFUoRjh5NUKxOFU9N2F-
U87MG.ΔEGFR MnHOS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFftR3h,OTByIN88US=> MoPBSG1UVw>? MVLJR|UxRThwNzFOwG0> NX3YWmd4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEe1NlE1PSd-OEe1NlE1PTxxYU6=
U87MG.wtEGFR. NWrTUohuT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NEXUSXl,OTByIN88US=> NUHsOGZTTE2VTx?= MlLrTWM2OD12OD60JO69VQ>? MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85PzV{MUS1K|45PzV{MUS1QE9iRg>?
U87MG M4LtcWtqdmG|ZTDhd5NigQ>? M3zPWZ4yODBizszN M1\qcWROW09? NW\jTmZXcW6qaXLpeJMhTUeIUjD0fZJwe2mwZTDrbY5ie2ViYXP0bZZqfHl? M3jXblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh5NUKxOFUoRjh5NUKxOFU9N2F-
U87MG.ΔEGFR MnrFT4lv[XOnIHHzd4F6 NF62O5p,OTByIN88US=> Mn;hSG1UVw>? NFjoe5pqdmirYnn0d{BGT0[UIIT5do9{cW6nIHvpcoF{\SCjY4Tpeol1gQ>? M2HJW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh5NUKxOFUoRjh5NUKxOFU9N2F-
U87MG.wtEGFR. NVu4VGFPU2mwYYPlJIF{e2G7 MXL+NVAxKM7:TR?= NYjVR2cxTE2VTx?= MYDpcohq[mm2czDFS2ZTKHS7cn;zbY5mKGurbnHz[UBi[3Srdnn0fS=> NUKzbId3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOEe1NlE1PSd-OEe1NlE1PTxxYU6=
HPV 16-immortalized human keratinocytes MYXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MWf+OVAh|ryP MUXEUXNQ MorZbY5pcWKrdIOgZ4VtdCCpcn;3eIg> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86Ojh6N{iyK|46Ojh6N{iyQE9iRg>?
HPV 16-immortalized human keratinocytes NHXwfXJHfW6ldHnvckBie3OjeR?= M3Xuep42OCEQvF2= NXG5cJV6TE2VTx?= MVTpcoR2[2W|IHHydoV{fCCrbjD0bIUhS2WubDDDfYNt\Q>? M3PEelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl{OEi3PFIoRjl{OEi3PFI9N2F-
HPV 16-immortalized human keratinocytes MUDBdI9xfG:|aYOgZZN{[Xl? MX7+OVAh|ryP MVzEUXNQ M3jjeIlv\HWlZYOgZZBweHSxc3nzMi=> MkLhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTJ6OEe4Nkc,QTJ6OEe4Nlww[T5?
A431 NGTCc|RMcW6jc3WgZZN{[Xl? MlLpglExKM7:TR?= NGXweGFFVVOR NEOyco9qdmirYnn0d{B1cGViYnHzZYwh[W6mIGTHSk3PuS2|dHnteYxifGWmIIT5do9{cW6nIIDoc5NxcG:{eXzheIlwdiCxZjD0bIUhTUeIUh?= M4L4XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyN{CyNlYzLz5zMEewNlI3OjxxYU6=
MDA-468  NXTtUZptU2mwYYPlJIF{e2G7 MnfGglExKM7:TR?= M16zO2ROW09? Mn\hbY5pcWKrdIOgeIhmKGKjc3HsJIFv\CCWR1[t{tEue3SrbYXsZZRm\CC2eYLvd4lv\SCyaH;zdIhwenmuYYTpc44hd2ZidHjlJGVITlJ? M1HN[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyN{CyNlYzLz5zMEewNlI3OjxxYU6=
A431 NHPLcJdHfW6ldHnvckBie3OjeR?= MmPYglExKM7:TR?= NIHjcnhFVVOR MWHpcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2 MlzvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB5MEKyOlIoRjFyN{CyNlYzRC:jPh?=
MDA-MB-231 NWi5[Y1PU2mwYYPlJIF{e2G7 MkHoglUh|ryP NW\xXYk1TE2VTx?= M{P4ZYlvcGmkaYTzJGVITiC|dHnteYxifGWmIIDoc5NxcG:{eXzheIlwdiCxZjDGT2hT NGrj[YM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUCzNFE1Pid-MUGwN|AyPDZ:L3G+
CNE2 NE\jNIlIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MVWxNFAh|ryP M2LIOWROW09? MUjpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gZpkhQThwNDW= NHzLWGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUSxNFMzOid-MUG0NVA{OjJ:L3G+
CNE2 M2f3R2tqdmG|ZTDhd5NigQ>? MmnOglExOCEQvF2= M3mzcmROW09? NFzKSJhqdmirYnn0d{BGT0[UIIT5do9{cW6nIIDoc5NxcG:{eXzheIlwdg>? NFXVTGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUSxNFMzOid-MUG0NVA{OjJ:L3G+
CNE2 NYH4PWZRTnWwY4Tpc44h[XO|YYm= MWP+NVAxKM7:TR?= M3P2UWROW09? M2TBOWlvcGmkaYTzJG1CWEtiYX7kJGFMXCCjY4TpeoF1cW:w M1G5fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNEGwN|IzLz5zMUSxNFMzOjxxYU6=
CNE2 NYHhTmczTnWwY4Tpc44h[XO|YYm= NWf0dnRkhjVyIN88US=> NXPOXHU5TE2VTx?= MX7h[oZm[3S|IHPlcIwh[3mlbHWg[Il{fHKrYoX0bY9v M33HWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzNEGwN|IzLz5zMUSxNFMzOjxxYU6=
HSC-2 NXTPfoE3U2mwYYPlJIF{e2G7 NFfUN405yqEQvF2= NGH3VIpFVVOR M3yx[YlvcGmkaYTzJJBpd3OyaH;yfYxifGmxbjDv[kBGT0[UIHHu[EBCc3R? MkSzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OEmyPFUoRjF5Nki5Nlg2RC:jPh?=
HSC-2 NF7weYlCeG:ydH;zbZMh[XO|YYm= NXnCe|J2QMLizszN Mn;wSG1UVw>? MYHpcohq[mm2czDGZZMudWWmaXH0[YQh[XCxcITvd4l{ MnniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4OEmyPFUoRjF5Nki5Nlg2RC:jPh?=
HEp-2 NYD4UG8{T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NUKy[HZOhjFyIN88US=> M1TE[2ROW09? NFfoSFNmdmijbnPld{Bwemmmb37pck1qdmS3Y3XkJIdzd3e2aD3pcohq[mm2b4L5 M4TnbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMkCyO|QyLz5{MEKwNlc1OTxxYU6=
SubG1 MXvBdI9xfG:|aYOgZZN{[Xl? NFnEbY1,OTBizszN M4jDOWROW09? M1rYeoVvcGGwY3XzJI9zcWSxbnnuMYlv\HWlZXSgZZBweHSxc3nz NGrUNIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEKwNlc1OSd-MkCyNFI4PDF:L3G+
HEp-2 M1q4XGZ2dmO2aX;uJIF{e2G7 NHXtc5F,OTBizszN NUXn[IE3TE2VTx?= NV3SenIz\W6qYX7j[ZMhV3KrZH;ubY4ucW6mdXPl[EBD[XhiYXP0bZZifGmxbjygRoNtNTJiZHXndoFl[XSrb36gZY5lKFOLUmSxJIlv[WO2aY\heIlwdg>? M2ThPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMkCyO|QyLz5{MEKwNlc1OTxxYU6=
H508 MoLFS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MnPhglEh|ryP MYPEUXNQ NHH0ZnBucXSrZ3H0[ZMhS1CILX3l[IlifGWmIFi1NFgh[2WubDDndo94fGh? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjVzNEmyOEc,OjZ3MUS5NlQ9N2F-
A431 M4npdGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M13nVnRme3SnZDDmc5Ih[W62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDBOFMyKGOnbHzzMEBKSzVyPUKw{txO NXLrepBQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUWxNFk3PDJpPkG1NVA6PjR{PD;hQi=>
HeLa NXj5PYZlTnWwY4Tpc44h[XO|YYm= Ml\KN|AhdWmwcx?= M4Gx[mlvcGmkaYTpc44hd2ZiRVfGVkBifXSxcHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKEinTHGgZ4VtdHNicILlbY5kfWKjdHXkJIZweiB|MDDtbY5{KHC{aX;yJJRwKEWJRjDzeIlufWyjdHnvckBjgSCZZYP0[ZJvKGKub4T0bY5o MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTdzOECyPUc,OjF5MUiwNlk9N2F-
BT-37 MnvRdWhVWyCjc4PhfS=> NYDadok3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFLUMVM4KGOnbHzz M37YfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-SH MULxTHRUKGG|c3H5 NEnqXVVyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1UUCClZXzsdy=> MmLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
NB1643 MlHLdWhVWyCjc4PhfS=> MUDxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhVkJzNkSzJINmdGy| MkfOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
OHS-50 M{PBeZFJXFNiYYPzZZk> MmTDdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKE:KUz21NEBk\Wyucx?= MoXYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
HEK293 NHrUT5dHfW6ldHnvckBie3OjeR?= NXLJUIdLOSCqch?= MoXvTY5pcWKrdHnvckBw\iCqdX3hckBnfWyuIHzlcod1cCCSS13ZWFEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{B2e2mwZzDFSnMhMDJ2NzD0c{AzPTlicnXzbYR2\XNrIHHzJJN2[nO2cnH0[UBi\nSncjCxJIhzKGK7IH\seY9z\XOlZX7j[UBxd2yjcnn6ZZRqd25iaX3teY5w[XOjeTygT4k:OS56N988US=> M2DDblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUSxNVk{Lz5{OUm0NVE6OzxxYU6=
HEK293 MoLtSpVv[3Srb36gZZN{[Xl? MV2xJIhz M{fCOmlvcGmkaYTpc44hd2ZiaIXtZY4h\nWubDDs[Y5ofGhiUFvNXXQyKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMhfXOrbnegSWZUKCh{NEegeI8hOjV7IILld4llfWW|KTDhd{B{fWK|dILheIUh[W[2ZYKgNUBpeiCkeTDmcJVwemW|Y3XuZ4UheG:uYYLpfoF1cW:wIHntcZVvd2G|YYmsJGlEPTB;MUmuOu69VQ>? M3PkV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUSxNVk{Lz5{OUm0NVE6OzxxYU6=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
EGFR / Neu / p-Tyr ; 

PubMed: 10931950     


MCF-10AyTE cells with or without AG-1478. After 24 h, cell lysates were prepared in EBC buffer and subjected to immunoblot procedures for EGFR, ErbB-2yNeu, and P-Tyr. Levels of a 180-kDa P-Tyr band, probably representing EGFR and ErbB-2yNeu, were reduced by AG-1478 without any change in receptor protein content.

Shc / PLC-γ1 ; 

PubMed: 10931950     


MCF-10AyTE cells with or without AG-1478. After 24 h, cell lysates were prepared in EBC buffer and subjected to immunoblot procedures for EGFR, ErbB-2yNeu, and P-Tyr. Levels of a 180-kDa P-Tyr band, probably representing EGFR and ErbB-2yNeu, were reduced by AG-1478 without any change in receptor protein content.

10931950
Growth inhibition assay
Cell viability ; 

PubMed: 25258648     


Dose-dependent effects of EGFR inhibitor AG-1478 on EGF-induced cell viability in OVCAR-3 cells. Cells were treated for 48 h with EGF (10 ng/mL) alone or in combination of AG-1478 (0, 0.25, 0.5 and 1 µmol/L). A cell viability assay was performed using MTT and values were normalized to untreated controls (no EGF, no inhibitors). Blackened bars were EGF treated. *, ** indicate a significant increase (p≤0.05) and # indicates a significant decrease (p≤0.05) between groups by ANOVA and Tukey’s pairwise comparisons. Experiments were performed in triplicate and all data are shown as mean ± SEM.

25258648
In vivo Administration of AG-1478 blocks phosphorylation of the EGFR at the tumor site and inhibits the growth of A431 xenografts that overexpress the WT EGFR and glioma xenografts expressing the de2-7 EGFR. Even subtherapeutic doses of AG-1478 significantly enhance the efficacy of cytotoxic drugs, with the combination of AG-1478 and temozolomide displaying synergistic antitumor activity against human glioma xenografts. The combination of AG-1478 and an anti-EGFR antibody (mAb 806) displays additive and in some cases synergistic, antitumor activity against tumor xenografts overexpressing the EGFR. [4] The combination of AG-1478 (0.4 mg) with a single dose of 25 μCi 90Y-CHX-A''-DTPA-hu3S193 results in a significant enhancement of efficacy compared with either agent alone. [5]

Protocol

Cell Research:

[2]

- Collapse
  • Cell lines: U87MG
  • Concentrations: Dissolved in DMSO, final concentrations ~100 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are exposed to different concentrations of AG-1478 for 72 hours in 96-well plates. The effects of AG-1478 on cell growth are examined using an Alamar Blue assay. A 20-μL aliquot of Alamar Blue is added to each well, and its absorbance is determined using a Spectromax Scanning Micro plate Reader. The effects of AG-1478 are expressed as percentage of growth inhibition using untreated cells as the control (0% inhibition). Cellular DNA synthesis is determined using a [3H]thymidine incorporation assay.


    (Only for Reference)
Animal Research:

[4]

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  • Animal Models: Female BALB/c nu/nu mice inoculated s.c. with A431 or U87MG.Δ2-7 tumor cells
  • Dosages: ~1 mg/kg
  • Administration: Injection i.p. three times per week
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 25 mg/mL (79.17 mM)
Water Insoluble
Ethanol ''13 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 315.75
Formula

C16H14ClN3O2

CAS No. 153436-53-4
Storage powder
in solvent
Synonyms NSC 693255
Smiles COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC

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The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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