Name: Cinacalcet
Brand: Selleck Chemicals
SKU: S5191
Rating: 5 (1 reviews)

Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.

Cinacalcet Chemical Structure

CAS: 226256-56-0

Selleck's Cinacalcet has been cited by 1 publication

Purity & Quality Control

Batch: S519101 Purity: 99.98%

99.98

Cinacalcet Related Products

Related Targets	Cav 2.2	Click to Expand
Related Compound Libraries	FDA-approved Drug Library Natural Product Library Ion Channel Ligand Library Exosome Secretion Related Compound Library Calcium Channel Blocker Library	Click to Expand

Signaling Pathway

Calcium Channel Signaling Pathway

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Biological Activity

Description

Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.

Targets

CaR ^[1]

In vitro
In vitro	Cinacalcet can activate CaSR and elicit an increase of atg7, becn and lc3a mRNA transcripts.^[2]
Cell Research	Cell lines	human AT-derived (primary) preadipocytes
	Concentrations	2 μM
	Incubation Time	6 h
	Method	Isolation of human AT-derived (primary) preadipocytes was performed. After passage 3 in culture with DMEM:F12 and 10% FBS, preadipocytes were switched to 2.5% FBS and exposed to cinacalcet, spermine and/or the upstream ERK (MAPK) inhibitor U0126, plus the autophagy flux inhibitor CQ for the last 2-3 h. CaSR activators were used for 6 h, while U0126 was used 1 h before exposure to the CaSR activator. (Data sourced from selleck products)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06144229	Not yet recruiting	Hiv\|Hpv	University of California Los Angeles\|Harvard School of Public Health (HSPH)\|Frontier Science & Technology Research Foundation Inc.\|Albert Einstein College of Medicine\|Boston Children''s Hospital\|St. Jude Children''s Research Hospital\|University of Colorado Denver\|Bronx-Lebanon Hospital Center Health Care System\|University of Miami\|Baylor College of Medicine\|Children''s Hospital New Orleans LA\|Jacobi Medical Center\|Ann & Robert H Lurie Children''s Hospital of Chicago\|Westat	April 2024	--
NCT05906758	Not yet recruiting	Acute Kidney Injury	Tulane University	March 2024	Phase 3
NCT06153849	Not yet recruiting	Bladder Cancer	Changhai Hospital	December 1 2023	--
NCT06052696	Not yet recruiting	Vulvar HSIL\|HPV	Erasmus Medical Center\|Dutch Cancer Society	December 1 2023	Phase 4
NCT06188104	Withdrawn	CIN1\|Trichloroacetic Acid	Rajavithi Hospital	November 30 2023	Phase 2\|Phase 3

References

Chemical Information & Solubility

Molecular Weight	357.41	Formula	C₂₂H₂₂F₃N
CAS No.	226256-56-0	SDF	--
Smiles	CC(NCCCC1=CC(=CC=C1)C(F)(F)F)C2=CC=CC3=CC=CC=C23
Storage (From the date of receipt)	2 years -20°C liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C liquid		1 month-20°Cin solvent

In vitro
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In vivo
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