For research use only.

Catalog No.S1831 Synonyms: BM-14190, SKF 105517

3 publications

Carvedilol Chemical Structure

CAS No. 72956-09-3

Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.

Selleck's Carvedilol has been cited by 3 publications

Purity & Quality Control

Choose Selective Adrenergic Receptor Inhibitors

Biological Activity

Description Carvedilol (BM-14190, SKF 105517) is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.
α1-adrenergic receptor [1] β1-adrenergic receptor [1]
In vitro

Carvedilol rapidly inhibits Fe(++)-initiated lipid peroxidation, measured as thiobarbituric acid reactive substance (TBARS), in rat brain homogenate with an IC50 of 8.1 mM. Carvedilol protects against Fe(++)-induced alpha-tocopherol depletion in rat brain homogenate with an IC50 of 17.6 mM. Carvedilol dose-dependently decreases the intensity of the DMPO-OH signal with an IC50 of 25 mM. [1] Carvedilol has inverse efficacy for stimulating G(s)-dependent adenylyl cyclase but stimulates phosphorylation of the receptor's cytoplasmic tail on previously documented G protein-coupled receptor kinase sites in beta2 adrenergic receptor (beta2AR)-expressing HEK-293 cells. [2] Carvedilol (0.1-10 mM) produces a concentration-dependent inhibition of the mitogenesis stimulated by platelet-derived growth factor, epidermal growth factor, thrombin, and serum in human cultured pulmonary artery vascular smooth muscle cells, with IC50 values ranging from 0.3 mM to 2.0 mM. Carvedilol also produces a concentration-dependent inhibition of vascular smooth muscle cell migration induced by platelet-derived growth factor, with an IC50 value of 3 mM. [3] Carvedilol decreases the extent of cellular vacuolization in cardiac myocytes and prevents the inhibitory effect of doxorubicin on mitochondrial respiration in both heart and liver. Carvedilol also prevents the decrease in mitochondrial Ca(2+) loading capacity and the inhibition of the respiratory complexes of heart mitochondria caused by doxorubicin. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
ScN2a-cl3 cells NX7FOmVqS3m2b4TvfIlkcXS7IHHzd4F6 MlfCR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3Wg[Il3cWSrbnegV4NPOmFvY3yzJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHHmeIVzKDViZHH5d{BjgSClYXzj[YlvNUGPIIP0ZYlvcW6pLXLhd4VlKG[udX;y[ZNk\W6lZTDhd5NigSxiTFO1NF03NjFizszN MVSyOFE5OzV6OR?=
HEK293 cells M3PKUGZ2dmO2aX;uJIF{e2G7 MonBN{BucW6| M2rJVWlvcGmkaYTpc44hd2ZiaIXtZY4hV0OWMj3t[YRq[XSnZDDBV3AsKHWydHHr[UBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIFnfGW{IEOgcYlveyCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTB;Nz61JO69VQ>? M3LYPFI{OjRzMEK5
CHO cells NH;De4hHfW6ldHnvckBie3OjeR?= MVjJcohq[mm2aX;uJI9nKGi3bXHuJGVTTyCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJIJ6KHeqb3zlJINmdGxicHH0Z4gh[2yjbYCgeIVkcG6rcYXlMEBKSzVyPUGwMlQ4OTNizszN NH;VTY4yQDR2OEO0Ni=>

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 81 mg/mL (199.27 mM)
Ethanol 4 mg/mL (9.84 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 406.47


CAS No. 72956-09-3
Storage powder
in solvent
Synonyms BM-14190, SKF 105517

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04198259 Not yet recruiting Procedure: interventional devascularization|Procedure: TIPS Gastric Varices Bleeding|Liver Cirrhoses Air Force Military Medical University China June 1 2020 Not Applicable
NCT03861598 Recruiting Drug: Carvedilol Glioblastoma Multiforme|Glioblastoma West Virginia University|West Virginia Clinical and Translational Science Institute July 19 2019 Early Phase 1
NCT03948685 Unknown status Drug: Carvedilol SR|Drug: Placebo Heart Failure With Preserved Ejection Fraction Yonsei University May 2019 Phase 4
NCT03748212 Unknown status Drug: D935 Cap. 1T|Drug: CKD-385 Tab. 1T Hypertension Chong Kun Dang Pharmaceutical October 24 2018 Phase 1
NCT03576664 Completed Drug: Carvedilol 25mg|Drug: Placebo oral capsule Sleep Deprivation|Sleep Wake Disorders|Sleep Gitte Moos Knudsen|Center for translational Neuroscience University of Copenhagen Denmark|Danish Center for Sleep Medicine|Rigshospitalet Denmark August 28 2018 Early Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Adrenergic Receptor Signaling Pathway Map

Related Adrenergic Receptor Products

Tags: buy Carvedilol | Carvedilol supplier | purchase Carvedilol | Carvedilol cost | Carvedilol manufacturer | order Carvedilol | Carvedilol distributor
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID