Chloramphenicol

Catalog No.S1677 Synonyms: Chloromycetin

Chloramphenicol Chemical Structure

Molecular Weight(MW): 323.13

Chloramphenicol is a bacteriostatic by inhibiting protein synthesis.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Chloramphenicol is a bacteriostatic by inhibiting protein synthesis.
In vitro

Chloramphenicol results in a constitutive increase in the level of cspA transcript and constitutive production of CS7.4. [1] Chloramphenicol down-regulates the mitochondrial DNA-encoded Cox I protein, but not nuclear-encoded proteins. Chloramphenicol increases cellular levels of the p21(waf1/cip1) protein and p21(waf1/cip1) mRNA through a p53-independent pathway. [2] Chloramphenicol, at concentrations greater than 0.1 g/L (0.3 mM), inhibits the denitrifying enzyme activity (DEA) of slurries of humisol and sandy loam soils by disrupting the activity of existing nitrate reductase enzymes. [3] Chloramphenicol, at concentrations from 5 mM to 2 mM initiates apoptosis in dividing cells from a monkey kidney-derived cell line and in haematopoietic progenitor cells from human neonatal cord blood. Chloramphenicol suppresses growth of progenitor cells. [4]

In vivo Chloramphenicol results in increased t1/2(beta) (by 209%), and decreased ClB (by 45%), and prolonged recovery indices (by 768 to 946%) in greyhounds. [5] Chloramphenicol suppresses increases in the body weight and liver weight of experimental animals and at the same time induced a remarkable increase in lipid peroxidation in the liver during the formation of megamitochondria. Chloramphenicol-induced formation of megamitochondria is not simply ascribed to the suppression of the dividing process of mitochondria due to lowered protein synthesis in mitochondria but is intimately related to oxidative stress. [6]

Protocol

Solubility (25°C)

In vitro DMSO 65 mg/mL (201.15 mM)
Ethanol 65 mg/mL (201.15 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 323.13
Formula

C11H12Cl2N2O5

CAS No. 56-75-7
Storage powder
in solvent
Synonyms Chloromycetin

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID