Cyclosporin A

Catalog No.S2286 Synonyms: Cyclosporine A

Cyclosporin A  Chemical Structure

Molecular Weight(MW): 1202.61

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

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Cited by 8 Publications

3 Customer Reviews

  • Repression of BSEP gene expression upon treatment with reported BSEP inhibitors in human primary hepatocytes. BSEP mRNA expression was measured using real-time PCR in hepatocytes from at least three donors upon treatment with BSEP inhibitors as described under Materials and Methods. All the data are expressed as mean ?S.D. (n = 3).

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

    Immunophilins participate in SOCE activation by CN-dependent but also CN-independent signaling pathways. Fura-2 loaded platelets were suspended in HBS, platelets are incubated for 5 min with cyclosporin A (CsA, 50 µM). Once incubation time was over, platelets were stimulated with TG (200 nM) in a calcium free-HBS (EGTA 100 μM was added as indicated the by arrowhead) and 4 min later CaCl2 (300 µM) was added to visualized calcium entry. Changes in fura-2 fluorescence were monitored using the 340/380nm ratio and calibrated in terms of [Ca2+]c . Traces are representative of four to six independent experiments. *,**, *** represents p < 0.05, p < 0.01 and p <0.001, respect control platelets.

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

  • CsA and FTY720 suppress HFD-induced hepatic fat accumulation. Mice were sacrificed at the end of experiment and liver samples were freshly collected and processed. (a) Representative images of liver samples with H&E staining. (b) Representative images of liver samples with Oil Red O staining. Scale bars represent 100 µm.

    Pharm Res, 2016, 33(2):395-403. Cyclosporin A purchased from Selleck.

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Biological Activity

Description Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.
Targets
calcineurin [1]
(Cell-free assay)
7 nM
In vitro

Cyclosporin A binds to the cyclophilin (immunophilin) in T cells[1] , forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. [2] Cyclosporin A inhibits calcineurin with IC50 of 7 nM[3], then blocks the nuclear translocation of NF-AT. [4] Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 cells MnPXSpVv[3Srb36gZZN{[Xl? NXLyNY17UW6qaXLpeIlwdiCxZjDsbZZmeiC|dHHn[UBRdGG|bX;kbZVuKGKncnfo[YkhcW6oZXP0bY9vKGmwIFjldGczKGOnbHzzMEBKSzVyPUGuOlUhdk1? MoXsNlI2QDZzMkS=
Jurkat cells MUXGeY5kfGmxbjDhd5NigQ>? NVfaNpNHUW2vdX7vd5VxeHKnc4PpeoUh[WO2aY\peJkhf2G|IH3lZZN2emWmIHL5JIlvcGmkaYTpc44hd2ZidHjlJGlNNTJicILv[JVkfGmxbjDpckBLfXKtYYSgZ4VtdHNuIFnDOVA:OiCwTR?= MlTQNVQ3PDN|M{e=
human PBMC M4PEe2Z2dmO2aX;uJIF{e2G7 MWixJIg> NHzUXFBCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJHBDVUNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjboTpMWNFOy:FREK4JIFvfGmkb3T5MYlv\HWlZXSgTWwuOiCycn;keYN1cW:wIITy[YF1\WRiZn;yJFEhcHJiYnXmc5JmKGGwdHmtR2Q{N0OGMkigZY51cWKxZImgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IE[gbJJ{KGK7IHntcZVvd3O3cIDy[ZN{cW:wIHHzd4F6NCCHQ{WwQVMvOSCwTR?= MmW0NVk6OzN5OUW=
human Jurkat cells NILMNolHfW6ldHnvckBie3OjeR?= MmPjNUBp NEHVUlFCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJGp2emujdDDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGGwdHmtR2Q{N0OGMkigZY51cWKxZImtbY5lfWOnZDDJUE0zKHC{b3T1Z5Rqd25idILlZZRm\CCob4KgNUBpeiCkZX\vdoUh[W62aT3DSFMwS0R{ODDhcpRq[m:meTDjbIFtdGWwZ3WgcYVie3W{ZXSgZYZ1\XJiNjDodpMh[nliaX3teY5we3WycILld5Nqd25iYYPzZZktKEWFNUC9OUBvVQ>? MlLvNVk6OzN5OUW=
human T-cell NEnIRXBHfW6ldHnvckBie3OjeR?= MnvoTY4hfmm2cn:gbY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGStZ4VtdCCycn;keYN1cW:wIH;mJIx6dXCqb3vpcoUhUUxvMjygTWM2OD16LkGgcm0> NHy2UGs4PTN5M{Ox
human splenocytes MWLGeY5kfGmxbjDhd5NigQ>? MljZOEBl[Xm| NV7pdVRCUW2vdX7vd5VxeHKnc4PpeoUh[WO2aY\peJkhcW5iaIXtZY4he3CuZX7vZ5l1\XNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlv[2:{cH;yZZRqd25iYX\0[ZIhPCCmYYnzJIJ6KGGubH;n[Y5q[yCvaYjl[EBtgW2yaH;jfZRmKHKnYXP0bY9vKGG|c3H5MEBKSzVyPUGwJI5O M3;ETVE6QDJ5OEOx
mouse T cells NUD6d3h{TnWwY4Tpc44h[XO|YYm= MojaOEBl[Xm| NWjJRlVEUW2vdX7vd5VxeHKnc4PpeoUh[WO2aY\peJkhcW5ibX;1d4UhXCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJR4dyC5YYmgcYl5\WRibIntdIhw[3m2ZTDy[YFkfGmxbjDh[pRmeiB2IHThfZMh[nliTWTUJIF{e2G7LDDpZ|UxRTFzIH7N MYmyNlk5PDl6Nx?=
human PBMC NUS3bJltWHKxbHnm[ZJifGmxbjDhd5NigQ>? M3fF[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFLNR{whUUN3ME2xNkBvVQ>? MWexOVY4QTNyOR?=
human MDA435/LCC6MDR cells M2naOmZ2dmO2aX;uJIF{e2G7 NXLEc3R2PSCmYYnz MWDNc4R2dGG2aX;uJI9nKFBvZ4CgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCqdX3hckBOTEF2M{WvUGNEPk2GUjDj[YxteyCjc4Pld5Nm\CCjczDy[ZZmenOrbnegdIFkdGm2YYjlcEBz\XOrc4ThcoNmKG2nYYP1doVlKGG|IHPlcIwhe3W{dnn2ZYwh[W[2ZYKgOUBl[Xm|IHL5JG1VWyCjc4PhfUwhTUN3ME2wMlA{OiEQvF2u MofXNlU6QDVzOUW=
HEK293 cells NWTFdm9ZTnWwY4Tpc44h[XO|YYm= NHr1ZZhKdmirYnn0bY9vKG:oIF;BWHAySjFiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IIDyc5RmcW5vbXXkbYF1\WRicHn0ZZZie3SjdHnuJJVxfGGtZf-8kEBMcT1yLkKg{txO NVW0N2lNOjJ3OEe5PFY>
CK1 cells NWLFb2RZTnWwY4Tpc44h[XO|YYm= NXzD[mdPSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUFCYLUOzJIlv\mWldHXkJIlvKEONMTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFch\GG7czygWGM2OD1yLkOg{txO MmjLNVgzOTJzMEC=
mouse mammary carcinoma cell line EMT6/AR 1.0 M4PzUmZ2dmO2aX;uJIF{e2G7 MXvS[ZZmenOjbDDl[oZm[3Rib36geIhmKGGlY4XteYxifGmxbjDv[kBcO0ifLTDkZZVvd3K3YnnjbY4hcW5ibX;1d4UhdWGvbXHyfUBk[XKlaX7vcYEh[2WubDDsbY5mKEWPVE[vRXIhOS5yLDDJR|UxRTBwNESg{txO Mlm2NVAxQTh4N{G=
KB cell Mn7iSpVv[3Srb36gZZN{[Xl? MY\Jcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgT2Ih[2WubDDsbY5mKGGodHXyJFczKGhib3[g[JJ2\yCneIDvd5Vz\SxiSVO1NF0xNjZizszN NVTaZXMyOTV2OEG5PVE>
mouse L5178 cells NVnvbG1sTnWwY4Tpc44h[XO|YYm= M4rLdlIxKG2rboO= NHHrS|lKdmirYnn0bY9vKG:oIHj1cYFvKEGEQ1KxMY1m\GmjdHXkJJJpd2SjbXnu[UAyOjNiZX\mcJV5KGmwIH3veZNmKEx3MUe4JINmdGy|IHX4dJJme3OrbnegbJVu[W5iTVTSNUBi\nSncjCyNEBucW6|IHL5JGZCS1NiYX7hcJl{cXNuIFnDOVA:OC54NTFOwG0> M4X2NVIyOzRzN{S1
LLC-PK1 epithelial cells NYn0VpdwTnWwY4Tpc44h[XO|YYm= M4HqTmlvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4tKG2xdYPlJGwudWS{MXKg[ZhxemW|c3XkJIlvKEyOQz3QT|Eh\XCrdHjlcIlidCClZXzsd{B2e2mwZzDjZYxk\WmwLVHNJJBwdGG{aYPheIlwdiCjc4Phfg+9lCCLQ{WwQVAvPyEQvF2= NYLWNYwxOTJ4OUmzPFk>
human K562/R7 cells MmnvSpVv[3Srb36gZZN{[Xl? MlLnNUDPxE1? NVO4WGE3PzJiaB?= MU\Qc5RmdnSrYYTpc44hd2ZiZH;4c5J2[mmlaX6tbY5lfWOnZDDjfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUzV4Mj;SO{Bk\WyuczDhd5Nme3OnZDDhd{Bld3ixcoXibYNqdiCLQ{WwJIF1KDFidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkeg{txO MkLwNlU3OzRyNEG=
A2780/ADR cells MYfGeY5kfGmxbjDhd5NigQ>? Mo\sTY5pcWKrdHnvckBw\iCSLXfsfYNweHKxdHXpckBmgHC{ZYPz[YQhcW5iQUK3PFAwSUSUIHPlcIx{KGK7IHPhcINmcW5iQV2gZZN{[XoxvJygTWM2OD1zLkSxNlU1KM7:TR?= NEDGVYYyPzh7MEC5OC=>
KB/MDR cell NEK4UYtHfW6ldHnvckBie3OjeR?= NVmyVIo2PzJiaB?= MXrJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgT2IwVUSUIHPlcIwhdGmwZTDh[pRmeiB5MjDodkBw\iCmcoXnJIV5eG:|dYLlMEBKSzVyPUGuOUDPxE1? NG\zUY8yPTR6MUm5NS=>
guinea pig ventricular myocytes MlTGSpVv[3Srb36gZZN{[Xl? MYHJcohq[mm2aX;uJI9nKExvdInw[UBk[WylaYXtJINp[W6wZXygcYVie3W{ZXSgeZNqdmdid3jvcIUu[2WubDDwZZRkcCClbHHtdEBqdiCpdXnu[YEheGmpII\lcpRzcWO3bHHyJI16d2O7dHXzMEBKSzVyPUKg{txO M{LwblIzPzZzMECw
human MDA435/LCC6MDR cells MWnDfZRwfG:6aXRCpIF{e2G7 M{C5VlczcA>? NVPST4tMS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiZYjwdoV{e2mwZzDNSHIh[W[2ZYKgO|IhcHK|78{MJGlEPTB;Mj64JO69VQ>? NYDaR4FYOjJ|MkC0NFI>
human Caco2 cells NG\MbVRHfW6ldHnvckBie3OjeR?= MXvubIljcXSrb36gc4YhWC2pcDDpckBpfW2jbjDDZYNwOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6g[Ilod3irbjDl[oZtfXhuIFnDOVA:Oi57IN88US=> NUm3NpNKOjN|OEK0OVg>
leukemia CEM cells MXzGeY5kfGmxbjDhd5NigQ>? M1f5SmlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDNSHIyKFBvR3z5Z49xem:2ZXnuJGFDSyCWcnHud5BwenSncjD1d4lv\yCuZYXr[Y1q[SCFRV2gZ4VtdHNuIFnDOVA:Oy52IN88US=> MlLxNVI{PjF|OEe=
human HeLa cells NVfHUXM4TnWwY4Tpc44h[XO|YYm= MXfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIVHYuOThiaX7m[YN1\WRiaX6gbJVu[W5iSHXMZUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDdiZHH5d-+9lCCWQ{WwQVQvPiEQvF2= M2\GTFE5OjF{MUCw
human 2008 cells NEThZWhHfW6ldHnvckBie3OjeR?= NIrlWmVKdmirYnn0bY9vKG:oIHj1cYFvKE2UUEGgbY4hcHWvYX6gNlAxQCClZXzsd{whUUN3ME20Mlc5KM7:TR?= NEPscZkyQDdyN{i4OC=>
human HuH7 cells NFXaNI5EgXSxdH;4bYPDqGG|c3H5 NH7UcnhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGG|c3Xzd4VlKGG|IILlcIVie2Vib3[gcIFkfGG2ZTDk[Yh6\HKxZ3XuZZNmNCCLQ{WwQVUvQDFizszN NIHpSlUzODl2M{O5NC=>
human Huh5-2 cells MV;DfZRwfG:6aXRCpIF{e2G7 MnPXN{Bl[Xm| MoX5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVpPS1{IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZkhNCCFQ{WwQVYh|ryP NYDlcHhjOTh4MkW3OlY>
human HuH6 cells M{jy[2N6fG:2b4jpZ:Kh[XO|YYm= NFfXUnM{KGSjeYO= NUjsTJB5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWKNjDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCFQ{WwQVch|ryP MUGxPFYzPTd4Nh?=
human Huh-9-13 cells NXTvXJd3S3m2b4TvfIlkyqCjc4PhfS=> NGPRfms{KGSjeYO= M2LzNmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2cC17LUGzJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XoxvJygR2M2OD15IN88US=> NVix[IMzOTh4MkW3OlY>
african green monkey Vero cells M1HvV2Z2dmO2aX;uJIF{e2G7 NXzBeWt[OjRiaB?= MU\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDX[ZN1KE6rbHWgeolzfXNiaX7m[YN1\WRiaX6gZYZzcWOjbjDndoVmdiCvb37r[ZkhXmW{bzDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckB3cXKjbDDSUmEhe3mwdHjld4l{KGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:QCEQvF2= NH7tOIcyQTR3MUK4Oi=>
human HeLa cells M4\HWWN6fG:2b4jpZ:Kh[XO|YYm= NUO3XpZVS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWOYTDj[YxteyxiVFO1NF05NjNizszN NF\6bpYyQDJzMkGwNC=>
human LCC-6 cells NIWwVWZEgXSxdH;4bYPDqGG|c3H5 MojHO|IhcA>? M3HTcWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGxESy14IHPlcIx{KGGodHXyJFczKGi{czygTWM2OD16LkOg{txO M3L3NlIzOzJyNECy
MDCK cells MlzmR5l1d3SxeHnjxsBie3OjeR?= NHXsXoVEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFPLJINmdGy|LDDUR|UxRTlwOTFOwG0> MYSxPFIyOjFyMB?=
human Huh-Mono cells NVHaN5BYS3m2b4TvfIlkyqCjc4PhfS=> M4PYV|Mh\GG7cx?= MkTtR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVpNU2xbn:gZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KE2WVDDhd5Nige,:jDDDR|UxRTJ2IN88US=> NHSzboQyQDZ{NUe2Oi=>
mouse L929 cells NF7GZnREgXSxdH;4bYPDqGG|c3H5 MnfQN{Bl[Xm| MkHJR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUFkzQSClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRUKGG|c3H5MEBKSzVyPUOwJO69VQ>? NGXuS|YzPTl6NUG5OS=>
rat H42E cells MYPDfZRwfG:6aXRCpIF{e2G7 M4HhO2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KHKjdDDIOFJGKGOnbHzzJIF{e2W|c3XkJIF{KGmwdILhZ4VtdHWuYYKgRXRRKGyndnXsMEBVSzVyPUSyJO69VQ>? NUC0R3BZOTl3MEKwOVg>

... Click to View More Cell Line Experimental Data

In vivo Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs. [6], is clinically used in organ transplantation to prevent rejection. [7]

Protocol

Kinase Assay:[3]
+ Expand

Phosphatase Assay:

Purified bovine brain calcineurin and calmodulin are purchased. Reaction mixtures with purified enzyme contains 100 nM calcineurin, 100 nM calmodulin, and 5 μM 32P-labeled phosphopeptide, in 60 μl (total volume) of assay buffer containing 20 mM Tris (pH 8), 100 mM NaCI, 6 mM MgCl2, 0.5 mM dithiothreitol, 0.1 mg of bovine serum albumin per ml, and either 0.1 mM CaCl2 or 5 mM EGTA. Reaction mixtures with cell lysates contains 20 μl of undiluted lysate, 5 μM 32P-labeled phosphopeptide, and 40 μl of assay buffer. Where indicated, reaction mixtures contains 50 μM peptide 412 or 413 and/or 500 nM okadaic acid, a specific inhibitor of phosphatases 1 and 2A; 500 nM okadaic acid is sufficient for inhibition of Ca2+-independent phosphatases, whereas higher concentrations partially inhibit Ca2+-dependent activity as well. After 15 min at 30°C, reactions are terminated by the addition of 0.5 ml of 100 mM potassium phosphate buffer (pH 7.0) containing 5% trichloroacetic acid. Free inorganic phosphate is isolated by Dowex cation-exchange chromatography and quantitated by scintillation counting as described.
Cell Research:[3]
+ Expand
  • Cell lines: Jurkat cells (clone J77)
  • Concentrations: ~100 nM
  • Incubation Time: 1 hr
  • Method: Immunosuppressive agents are dissolved in ethanol at concentrations 1000-fold more than the concentration desired for cell treatments. Cells (106) are suspended in 1 ml of complete medium in microcentrifuge tubes; 1 μl of ethanol or of the ethanolic solution of Cyclosporin A is added, and the cells are incubated at 37°C for 1 hr. Cells are washed twice with 1 ml of PBS on ice and lysed in 50μl of hypotonic buffer containing 50 mM Tris (pH 7.5); 0.1 mM EGTA; 1 mM EDTA; 0.5 mM dithiothreitol; and 50 μg of phenylmethylsulfonyl fluoride, 50 μg of soybean trypsin inhibitor, 5 μg of leupeptin, and 5 μg of aprotinin per ml. Lysates are subjected to three cycles of freezing in liquid nitrogen followed by thawing at 30°C and then are centrifuged at 4°C for 10 min at 12,000×g.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Rat
  • Formulation: 0.5% solution of tragacanth
  • Dosages: 45 mg/kg
  • Administration: orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (83.15 mM)
Ethanol 100 mg/mL warmed (83.15 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1202.61
Formula

C62H111N11O12

CAS No. 59865-13-3
Storage powder
in solvent
Synonyms Cyclosporine A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03657342 Recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. March 2019 Phase 3
NCT03656926 Recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. March 2019 Phase 3
NCT03657342 Recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. March 2019 Phase 3
NCT03656926 Recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. March 2019 Phase 3
NCT03710044 Not yet recruiting Atopic Dermatitis LEO Pharma January 2019 Phase 4
NCT03336632 Not yet recruiting Leukemia Acute|MDS Sichuan University January 1 2019 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What is the difference between S2286 (cyclosporin A) and S1514 (cyclosporin)?

  • Answer:

    Cyclosporine is a mixture of Cyclosporine A, derivatives of Cyclosporine A, salts of Cyclosporine A. Cyclosporine A is an especially useful Cyclosporine component.

Tags: buy Cyclosporin A | Cyclosporin A supplier | purchase Cyclosporin A | Cyclosporin A cost | Cyclosporin A manufacturer | order Cyclosporin A | Cyclosporin A distributor
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID