Cyclosporin A

Catalog No.S2286 Synonyms: Cyclosporine A

Cyclosporin A  Chemical Structure

Molecular Weight(MW): 1202.61

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

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In DMSO USD 130 In stock
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Cited by 7 Publications

3 Customer Reviews

  • Repression of BSEP gene expression upon treatment with reported BSEP inhibitors in human primary hepatocytes. BSEP mRNA expression was measured using real-time PCR in hepatocytes from at least three donors upon treatment with BSEP inhibitors as described under Materials and Methods. All the data are expressed as mean ?S.D. (n = 3).

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

    Immunophilins participate in SOCE activation by CN-dependent but also CN-independent signaling pathways. Fura-2 loaded platelets were suspended in HBS, platelets are incubated for 5 min with cyclosporin A (CsA, 50 µM). Once incubation time was over, platelets were stimulated with TG (200 nM) in a calcium free-HBS (EGTA 100 μM was added as indicated the by arrowhead) and 4 min later CaCl2 (300 µM) was added to visualized calcium entry. Changes in fura-2 fluorescence were monitored using the 340/380nm ratio and calibrated in terms of [Ca2+]c . Traces are representative of four to six independent experiments. *,**, *** represents p < 0.05, p < 0.01 and p <0.001, respect control platelets.

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

  • CsA and FTY720 suppress HFD-induced hepatic fat accumulation. Mice were sacrificed at the end of experiment and liver samples were freshly collected and processed. (a) Representative images of liver samples with H&E staining. (b) Representative images of liver samples with Oil Red O staining. Scale bars represent 100 µm.

    Pharm Res, 2016, 33(2):395-403. Cyclosporin A purchased from Selleck.

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Biological Activity

Description Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.
Targets
calcineurin [1]
(Cell-free assay)
7 nM
In vitro

Cyclosporin A binds to the cyclophilin (immunophilin) in T cells[1] , forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. [2] Cyclosporin A inhibits calcineurin with IC50 of 7 nM[3], then blocks the nuclear translocation of NF-AT. [4] Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 cells MnixSpVv[3Srb36gZZN{[Xl? NW\Eb4d{UW6qaXLpeIlwdiCxZjDsbZZmeiC|dHHn[UBRdGG|bX;kbZVuKGKncnfo[YkhcW6oZXP0bY9vKGmwIFjldGczKGOnbHzzMEBKSzVyPUGuOlUhdk1? NF;ZPHQzOjV6NkGyOC=>
Jurkat cells MVjGeY5kfGmxbjDhd5NigQ>? NFrFfJFKdW23bn;zeZBxemW|c3n2[UBi[3Srdnn0fUB4[XNibXXhd5Vz\WRiYomgbY5pcWKrdHnvckBw\iC2aHWgTWwuOiCycn;keYN1cW:wIHnuJGp2emujdDDj[YxteyxiSVO1NF0zKG6P NGqy[owyPDZ2M{OzOy=>
human PBMC MX\GeY5kfGmxbjDhd5NigQ>? NHnjbWYyKGh? Mn2yRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDQRm1EKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[W62aT3DSFMwS0R{ODDhcpRq[m:meT3pcoR2[2WmIFnMMVIheHKxZIXjeIlwdiC2cnXheIVlKG[xcjCxJIhzKGKnZn;y[UBidnSrLVPEN{9ETDJ6IHHueIljd2S7IHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB4IHjyd{BjgSCrbX31co9{fXCycnXzd4lwdiCjc4PhfUwhTUN3ME2zMlEhdk1? MlXVNVk6OzN5OUW=
human Jurkat cells M2W1cWZ2dmO2aX;uJIF{e2G7 M3yzTlEhcA>? M4DkZ2FvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gTpVzc2G2IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[W62aT3DSFMwS0R{ODDhcpRq[m:meT3pcoR2[2WmIFnMMVIheHKxZIXjeIlwdiC2cnXheIVlKG[xcjCxJIhzKGKnZn;y[UBidnSrLVPEN{9ETDJ6IHHueIljd2S7IHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB4IHjyd{BjgSCrbX31co9{fXCycnXzd4lwdiCjc4PhfUwhTUN3ME21JI5O M4TJSFE6QTN|N{m1
human T-cell NHewUmZHfW6ldHnvckBie3OjeR?= NFLD[HFKdiC4aYTyc{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gWE1k\WyuIIDyc4R2[3Srb36gc4YhdHmvcHjvb4lv\SCLTD2yMEBKSzVyPUiuNUBvVQ>? M2HRN|c2Ozd|M{G=
human splenocytes MX;GeY5kfGmxbjDhd5NigQ>? MWK0JIRigXN? M3vWbGludXWwb4P1dJBz\XO|aY\lJIFkfGm4aYT5JIlvKGi3bXHuJJNxdGWwb3P5eIV{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhYzOKXYTofY1q\GmwZTDpcoNwenCxcnH0bY9vKGGodHXyJFQh\GG7czDifUBidGyxZ3XubYMhdWm6ZXSgcJlueGixY4n0[UBz\WGldHnvckBie3OjeTygTWM2OD1zMDDuUS=> M2f1S|E6QDJ5OEOx
mouse T cells NULCUlJXTnWwY4Tpc44h[XO|YYm= M2TOTVQh\GG7cx?= MkjaTY1ufW6xc4XwdJJme3OrdnWgZYN1cX[rdImgbY4hdW:3c3WgWEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIT3c{B4[XlibXn4[YQhdHmvcHjvZ5l1\SC{ZXHjeIlwdiCjZoTldkA1KGSjeYOgZpkhVVSWIHHzd4F6NCCrY{WwQVEyKG6P MViyNlk5PDl6Nx?=
human PBMC MVTQdo9tcW[ncnH0bY9vKGG|c3H5 M4LEdWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFLNR{whUUN3ME2xNkBvVQ>? M3[xO|E2Pjd7M{C5
human MDA435/LCC6MDR cells NIjFW|RHfW6ldHnvckBie3OjeR?= M4DjVlUh\GG7cx?= NHW1d4xOd2S3bHH0bY9vKG:oIGCt[5AhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDoeY1idiCPRFG0N|UwVEOFNl3EVkBk\WyuczDhd5Nme3OnZDDhd{Bz\X[ncoPpcocheGGlbHn0ZZhmdCC{ZYPpd5RidmOnIH3lZZN2emWmIHHzJINmdGxic4Xyeol3[WxiYX\0[ZIhPSCmYYnzJIJ6KE2WUzDhd5NigSxiRVO1NF0xNjB|MjFOwG0v MUeyOVk5PTF7NR?=
HEK293 cells MYjGeY5kfGmxbjDhd5NigQ>? MVPJcohq[mm2aX;uJI9nKE:DVGCxRlEhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIF{e2W|c3XkJIF{KHC{b4TlbY4udWWmaXH0[YQheGm2YY\hd5RifGmwIIXweIFs\e,:jDDLbV0xNjJizszN NVvmdWVQOjJ3OEe5PFY>
CK1 cells NXrEPXZLTnWwY4Tpc44h[XO|YYm= MUjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIVHYuOzNiaX7m[YN1\WRiaX6gR2syKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiNzDkZZl{NCCWQ{WwQVAvOyEQvF2= Mmf2NVgzOTJzMEC=
mouse mammary carcinoma cell line EMT6/AR 1.0 NXXJcY9CTnWwY4Tpc44h[XO|YYm= NFf4dpdT\X[ncoPhcEBm\m[nY4Sgc44hfGinIHHjZ5VufWyjdHnvckBw\iCdM1jdMUBl[XWwb4L1ZolkcW5iaX6gcY92e2VibXHtcYFzgSClYYLjbY5wdWFiY3XscEBtcW6nIFXNWFYwSVJiMT6wMEBKSzVyPUCuOFQh|ryP NWPSR|ZnOTByOUi2O|E>
KB cell M16zdWZ2dmO2aX;uJIF{e2G7 Ml7jTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGtDKGOnbHygcIlv\SCjZoTldkA4OiCqIH;mJIRzfWdiZYjwc5N2emVuIFnDOVA:OC54IN88US=> MlnyNVU1QDF7OUG=
mouse L5178 cells NUW4SJlzTnWwY4Tpc44h[XO|YYm= MUiyNEBucW6| M{fYbWlvcGmkaYTpc44hd2ZiaIXtZY4hSUKFQkGtcYVlcWG2ZXSgdohw\GGvaX7lJFEzOyCnZn\seZghcW5ibX;1d4UhVDVzN{igZ4VtdHNiZYjwdoV{e2mwZzDoeY1idiCPRGKxJIFnfGW{IEKwJI1qdnNiYomgSmFEWyCjbnHsfZNqeyxiSVO1NF0xNjZ3IN88US=> MWSyNVM1OTd2NR?=
LLC-PK1 epithelial cells NYXQOYFuTnWwY4Tpc44h[XO|YYm= M{XqN2lvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4tKG2xdYPlJGwudWS{MXKg[ZhxemW|c3XkJIlvKEyOQz3QT|Eh\XCrdHjlcIlidCClZXzsd{B2e2mwZzDjZYxk\WmwLVHNJJBwdGG{aYPheIlwdiCjc4Phfg+9lCCLQ{WwQVAvPyEQvF2= MonwNVI3QTl|OEm=
human K562/R7 cells NUXTeFhMTnWwY4Tpc44h[XO|YYm= NYfEXVh4OSEQvF2= MkHuO|IhcA>? MULQc5RmdnSrYYTpc44hd2ZiZH;4c5J2[mmlaX6tbY5lfWOnZDDjfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUzV4Mj;SO{Bk\WyuczDhd5Nme3OnZDDhd{Bld3ixcoXibYNqdiCLQ{WwJIF1KDFidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkeg{txO NH3aflkzPTZ|NEC0NS=>
A2780/ADR cells NXL4eVIxTnWwY4Tpc44h[XO|YYm= M{nreWlvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4h\XiycnXzd4VlKGmwIFGyO|gxN0GGUjDj[YxteyCkeTDjZYxk\WmwIFHNJIF{e2G778{MJGlEPTB;MT60NVI2PCEQvF2= MV6xO|g6ODB7NB?=
KB/MDR cell M4WyfWZ2dmO2aX;uJIF{e2G7 MnWyO|IhcA>? MXjJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgT2IwVUSUIHPlcIwhdGmwZTDh[pRmeiB5MjDodkBw\iCmcoXnJIV5eG:|dYLlMEBKSzVyPUGuOUDPxE1? M4r2clE2PDhzOUmx
guinea pig ventricular myocytes NIXa[IlHfW6ldHnvckBie3OjeR?= MVLJcohq[mm2aX;uJI9nKExvdInw[UBk[WylaYXtJINp[W6wZXygcYVie3W{ZXSgeZNqdmdid3jvcIUu[2WubDDwZZRkcCClbHHtdEBqdiCpdXnu[YEheGmpII\lcpRzcWO3bHHyJI16d2O7dHXzMEBKSzVyPUKg{txO MlmxNlI4PjFyMEC=
human MDA435/LCC6MDR cells MmfuR5l1d3SxeHnjxsBie3OjeR?= MYG3Nog> NXvRNI5vS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiZYjwdoV{e2mwZzDNSHIh[W[2ZYKgO|IhcHK|78{MJGlEPTB;Mj64JO69VQ>? NEPHZXIzOjN{MESwNi=>
human Caco2 cells NHzVTpNHfW6ldHnvckBie3OjeR?= NXPCdFUzdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hS2Glb{KgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJIlvKGSrZ3;4bY4h\W[obIX4MEBKSzVyPUKuPUDPxE1? NHrQeZUzOzN6MkS1PC=>
leukemia CEM cells MVrGeY5kfGmxbjDhd5NigQ>? M1O2eGlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBJfW2jbjDNSHIyKFBvR3z5Z49xem:2ZXnuJGFDSyCWcnHud5BwenSncjD1d4lv\yCuZYXr[Y1q[SCFRV2gZ4VtdHNuIFnDOVA:Oy52IN88US=> NUO5Z3ZjOTJ|NkGzPFc>
human HeLa cells NYfvW5VGTnWwY4Tpc44h[XO|YYm= MVfBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIVHYuOThiaX7m[YN1\WRiaX6gbJVu[W5iSHXMZUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDdiZHH5d-+9lCCWQ{WwQVQvPiEQvF2= MVuxPFIyOjFyMB?=
human 2008 cells MVHGeY5kfGmxbjDhd5NigQ>? MkjkTY5pcWKrdHnvckBw\iCqdX3hckBOWlBzIHnuJIh2dWGwIEKwNFgh[2WubIOsJGlEPTB;ND63PEDPxE1? MVWxPFcxPzh6NB?=
human HuH7 cells M1jlPGN6fG:2b4jpZ:Kh[XO|YYm= NE[2d2tEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGG|c3Xzd4VlKGG|IILlcIVie2Vib3[gcIFkfGG2ZTDk[Yh6\HKxZ3XuZZNmNCCLQ{WwQVUvQDFizszN NELlSYYzODl2M{O5NC=>
human Huh5-2 cells NYDKPWxnS3m2b4TvfIlkyqCjc4PhfS=> NYH1T3BnOyCmYYnz MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeYg2NTJiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUAtKEOFNUC9OkDPxE1? NIW3PIsyQDZ{NUe2Oi=>
human HuH6 cells NUXzVoVsS3m2b4TvfIlkyqCjc4PhfS=> MYCzJIRigXN? MmTkR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVJPiClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRVKGG|c3H5MEBESzVyPUeg{txO NEDB[GYyQDZ{NUe2Oi=>
human Huh-9-13 cells NI\vW4hEgXSxdH;4bYPDqGG|c3H5 NYPmdoRMOyCmYYnz NV\KS5JFS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWqLUmtNVMh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3Ojef-8kEBESzVyPUeg{txO MlLBNVg3OjV5Nk[=
african green monkey Vero cells NF71SJFHfW6ldHnvckBie3OjeR?= M4TIR|I1KGh? NHi4TY1CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBY\XO2IF7pcIUhfmm{dYOgbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC4aYLhcEBTVkFic4nueIhme2m|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;ODFOwG0> MoD3NVk1PTF{OE[=
human HeLa cells M4rCUGN6fG:2b4jpZ:Kh[XO|YYm= Mo\hR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTIVN[SClZXzsd{whXEN3ME24MlMh|ryP M3;wfFE5OjF{MUCw
human LCC-6 cells NWfr[WdqS3m2b4TvfIlkyqCjc4PhfS=> MoXaO|IhcA>? MnL3R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUGNENTZiY3XscJMh[W[2ZYKgO|IhcHK|LDDJR|UxRThwMzFOwG0> M1W2[FIzOzJyNECy
MDCK cells MmXGR5l1d3SxeHnjxsBie3OjeR?= NWHSOY5[S3m2b4TvfIlkcXS7IHHnZYlve3RiTVTDT{Bk\WyuczygWGM2OD17Lkmg{txO NVjtN3I5OTh{MUKxNFA>
human Huh-Mono cells MYPDfZRwfG:6aXRCpIF{e2G7 MV[zJIRigXN? MXrDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIeYguVW:wbzDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F697zOIFPDOVA:OjRizszN Mn25NVg3OjV5Nk[=
mouse L929 cells NEfZOohEgXSxdH;4bYPDqGG|c3H5 NGLYNlg{KGSjeYO= NIPvclREgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBNQTJ7IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFNiYYPzZZktKEmFNUC9N|Ah|ryP MXyyOVk5PTF7NR?=
rat H42E cells MWfDfZRwfG:6aXRCpIF{e2G7 NXXGdVVSS3m2b4TvfIlkcXS7IHHnZYlve3RicnH0JGg1OkViY3XscJMh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBCXFBibHX2[YwtKFSFNUC9OFIh|ryP MYixPVUxOjB3OB?=

... Click to View More Cell Line Experimental Data

In vivo Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs. [6], is clinically used in organ transplantation to prevent rejection. [7]

Protocol

Kinase Assay:[3]
+ Expand

Phosphatase Assay:

Purified bovine brain calcineurin and calmodulin are purchased. Reaction mixtures with purified enzyme contains 100 nM calcineurin, 100 nM calmodulin, and 5 μM 32P-labeled phosphopeptide, in 60 μl (total volume) of assay buffer containing 20 mM Tris (pH 8), 100 mM NaCI, 6 mM MgCl2, 0.5 mM dithiothreitol, 0.1 mg of bovine serum albumin per ml, and either 0.1 mM CaCl2 or 5 mM EGTA. Reaction mixtures with cell lysates contains 20 μl of undiluted lysate, 5 μM 32P-labeled phosphopeptide, and 40 μl of assay buffer. Where indicated, reaction mixtures contains 50 μM peptide 412 or 413 and/or 500 nM okadaic acid, a specific inhibitor of phosphatases 1 and 2A; 500 nM okadaic acid is sufficient for inhibition of Ca2+-independent phosphatases, whereas higher concentrations partially inhibit Ca2+-dependent activity as well. After 15 min at 30°C, reactions are terminated by the addition of 0.5 ml of 100 mM potassium phosphate buffer (pH 7.0) containing 5% trichloroacetic acid. Free inorganic phosphate is isolated by Dowex cation-exchange chromatography and quantitated by scintillation counting as described.
Cell Research:[3]
+ Expand
  • Cell lines: Jurkat cells (clone J77)
  • Concentrations: ~100 nM
  • Incubation Time: 1 hr
  • Method: Immunosuppressive agents are dissolved in ethanol at concentrations 1000-fold more than the concentration desired for cell treatments. Cells (106) are suspended in 1 ml of complete medium in microcentrifuge tubes; 1 μl of ethanol or of the ethanolic solution of Cyclosporin A is added, and the cells are incubated at 37°C for 1 hr. Cells are washed twice with 1 ml of PBS on ice and lysed in 50μl of hypotonic buffer containing 50 mM Tris (pH 7.5); 0.1 mM EGTA; 1 mM EDTA; 0.5 mM dithiothreitol; and 50 μg of phenylmethylsulfonyl fluoride, 50 μg of soybean trypsin inhibitor, 5 μg of leupeptin, and 5 μg of aprotinin per ml. Lysates are subjected to three cycles of freezing in liquid nitrogen followed by thawing at 30°C and then are centrifuged at 4°C for 10 min at 12,000×g.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Rat
  • Formulation: 0.5% solution of tragacanth
  • Dosages: 45 mg/kg
  • Administration: orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (83.15 mM)
Ethanol 100 mg/mL warmed (83.15 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1202.61
Formula

C62H111N11O12

CAS No. 59865-13-3
Storage powder
in solvent
Synonyms Cyclosporine A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03657342 Recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. March 2019 Phase 3
NCT03656926 Recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. March 2019 Phase 3
NCT03657342 Recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. March 2019 Phase 3
NCT03656926 Recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. March 2019 Phase 3
NCT03710044 Not yet recruiting Atopic Dermatitis LEO Pharma January 2019 Phase 4
NCT03336632 Not yet recruiting Leukemia Acute|MDS Sichuan University January 1 2019 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    What is the difference between S2286 (cyclosporin A) and S1514 (cyclosporin)?

  • Answer:

    Cyclosporine is a mixture of Cyclosporine A, derivatives of Cyclosporine A, salts of Cyclosporine A. Cyclosporine A is an especially useful Cyclosporine component.

Tags: buy Cyclosporin A | Cyclosporin A supplier | purchase Cyclosporin A | Cyclosporin A cost | Cyclosporin A manufacturer | order Cyclosporin A | Cyclosporin A distributor
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID