Cyclosporin A

Catalog No.S2286 Synonyms: Cyclosporine A

Cyclosporin A  Chemical Structure

Molecular Weight(MW): 1202.61

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

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Cited by 14 Publications

3 Customer Reviews

  • Repression of BSEP gene expression upon treatment with reported BSEP inhibitors in human primary hepatocytes. BSEP mRNA expression was measured using real-time PCR in hepatocytes from at least three donors upon treatment with BSEP inhibitors as described under Materials and Methods. All the data are expressed as mean ?S.D. (n = 3).

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

  • Immunophilins participate in SOCE activation by CN-dependent but also CN-independent signaling pathways. Fura-2 loaded platelets were suspended in HBS, platelets are incubated for 5 min with cyclosporin A (CsA, 50 µM). Once incubation time was over, platelets were stimulated with TG (200 nM) in a calcium free-HBS (EGTA 100 μM was added as indicated the by arrowhead) and 4 min later CaCl2 (300 µM) was added to visualized calcium entry. Changes in fura-2 fluorescence were monitored using the 340/380nm ratio and calibrated in terms of [Ca2+]c . Traces are representative of four to six independent experiments. *,**, *** represents p < 0.05, p < 0.01 and p <0.001, respect control platelets.

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

  • CsA and FTY720 suppress HFD-induced hepatic fat accumulation. Mice were sacrificed at the end of experiment and liver samples were freshly collected and processed. (a) Representative images of liver samples with H&E staining. (b) Representative images of liver samples with Oil Red O staining. Scale bars represent 100 µm.

    Pharm Res, 2016, 33(2):395-403. Cyclosporin A purchased from Selleck.

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Biological Activity

Description Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.
Targets
calcineurin [1]
(Cell-free assay)
7 nM
In vitro

Cyclosporin A binds to the cyclophilin (immunophilin) in T cells[1] , forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. [2] Cyclosporin A inhibits calcineurin with IC50 of 7 nM[3], then blocks the nuclear translocation of NF-AT. [4] Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 cells NYD1b3hWTnWwY4Tpc44h[XO|YYm= M2XFdWlvcGmkaYTpc44hd2ZibHn2[ZIhe3SjZ3WgVIxie22xZHn1cUBj\XKpaHXpJIlv\mWldHnvckBqdiCKZYDHNkBk\WyuczygTWM2OD1zLk[1JI5O NVG0ZXhiOjJ3OE[xNlQ>
Jurkat cells NHj4cXBHfW6ldHnvckBie3OjeR?= M1LQbWludXWwb4P1dJBz\XO|aY\lJIFkfGm4aYT5JJdieyCvZXHzeZJm\CCkeTDpcohq[mm2aX;uJI9nKHSqZTDJUE0zKHC{b3T1Z5Rqd25iaX6gTpVzc2G2IHPlcIx{NCCLQ{WwQVIhdk1? NIDoZWQyPDZ2M{OzOy=>
human PBMC MUDGeY5kfGmxbjDhd5NigQ>? NUftS|N7OSCq NHjCZVVCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJHBDVUNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjboTpMWNFOy:FREK4JIFvfGmkb3T5MYlv\HWlZXSgTWwuOiCycn;keYN1cW:wIITy[YF1\WRiZn;yJFEhcHJiYnXmc5JmKGGwdHmtR2Q{N0OGMkigZY51cWKxZImgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IE[gbJJ{KGK7IHntcZVvd3O3cIDy[ZN{cW:wIHHzd4F6NCCHQ{WwQVMvOSCwTR?= MnLUNVk6OzN5OUW=
human Jurkat cells MkfBSpVv[3Srb36gZZN{[Xl? MW[xJIg> M3XBeGFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gTpVzc2G2IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh[W62aT3DSFMwS0R{ODDhcpRq[m:meT3pcoR2[2WmIFnMMVIheHKxZIXjeIlwdiC2cnXheIVlKG[xcjCxJIhzKGKnZn;y[UBidnSrLVPEN{9ETDJ6IHHueIljd2S7IHPoZYxt\W6pZTDt[YF{fXKnZDDh[pRmeiB4IHjyd{BjgSCrbX31co9{fXCycnXzd4lwdiCjc4PhfUwhTUN3ME21JI5O M4\IWFE6QTN|N{m1
human T-cell NYq5R|M5TnWwY4Tpc44h[XO|YYm= NIfvV2FKdiC4aYTyc{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhcHWvYX6gWE1k\WyuIIDyc4R2[3Srb36gc4YhdHmvcHjvb4lv\SCLTD2yMEBKSzVyPUiuNUBvVQ>? NY\V[Y5LPzV|N{OzNS=>
human splenocytes M2fL[GZ2dmO2aX;uJIF{e2G7 NEixOJM1KGSjeYO= M{XySGludXWwb4P1dJBz\XO|aY\lJIFkfGm4aYT5JIlvKGi3bXHuJJNxdGWwb3P5eIV{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhYzOKXYTofY1q\GmwZTDpcoNwenCxcnH0bY9vKGGodHXyJFQh\GG7czDifUBidGyxZ3XubYMhdWm6ZXSgcJlueGixY4n0[UBz\WGldHnvckBie3OjeTygTWM2OD1zMDDuUS=> M1fLTlE6QDJ5OEOx
mouse T cells MlLXSpVv[3Srb36gZZN{[Xl? NHHI[Fg1KGSjeYO= MX;JcY12dm:|dYDwdoV{e2m4ZTDhZ5Rqfmm2eTDpckBud3W|ZTDUJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidIfvJJdigSCvaYjl[EBtgW2yaH;jfZRmKHKnYXP0bY9vKGGodHXyJFQh\GG7czDifUBOXFRiYYPzZZktKGmlNUC9NVEhdk1? NXL0dHpuOjJ7OES5PFc>
human PBMC NWq4cIQ1WHKxbHnm[ZJifGmxbjDhd5NigQ>? MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCETVOsJGlEPTB;MUKgcm0> NVnsSlBPOTV4N{mzNFk>
human MDA435/LCC6MDR cells M1fpbWZ2dmO2aX;uJIF{e2G7 MX[1JIRigXN? MWfNc4R2dGG2aX;uJI9nKFBvZ4CgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCqdX3hckBOTEF2M{WvUGNEPk2GUjDj[YxteyCjc4Pld5Nm\CCjczDy[ZZmenOrbnegdIFkdGm2YYjlcEBz\XOrc4ThcoNmKG2nYYP1doVlKGG|IHPlcIwhe3W{dnn2ZYwh[W[2ZYKgOUBl[Xm|IHL5JG1VWyCjc4PhfUwhTUN3ME2wMlA{OiEQvF2u M4LRUlI2QTh3MUm1
HEK293 cells MVXGeY5kfGmxbjDhd5NigQ>? MnPkTY5pcWKrdHnvckBw\iCRQWTQNWIyKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCycn;0[YlvNW2nZHnheIVlKHCrdHH2ZZN1[XSrbjD1dJRic2YxvJygT4k:OC5{IN88US=> MnPZNlI2QDd7OE[=
CK1 cells NEjiUHNHfW6ldHnvckBie3OjeR?= Mnn5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTHBXNTN|IHnu[oVkfGWmIHnuJGNMOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEeg[IF6eyxiVFO1NF0xNjNizszN MVexPFIyOjFyMB?=
mouse mammary carcinoma cell line EMT6/AR 1.0 MkjpSpVv[3Srb36gZZN{[Xl? MnyyVoV3\XK|YXyg[YZn\WO2IH;uJJRp\SCjY3P1cZVt[XSrb36gc4YhYzOKXT2g[IF2dm:{dXLpZ4lvKGmwIH3veZNmKG2jbX3hdpkh[2G{Y3nuc41iKGOnbHygcIlv\SCHTWS2M2FTKDFwMDygTWM2OD1yLkS0JO69VQ>? M1rw[FExODl6Nkex
KB cell M3\FcmZ2dmO2aX;uJIF{e2G7 NWjlbmE2UW6qaXLpeI9zgSCjY4Tpeol1gSCjZ3HpcpN1KEuEIHPlcIwhdGmwZTDh[pRmeiB5MjDoJI9nKGS{dXeg[Zhxd3O3cnWsJGlEPTB;MD62JO69VQ>? MmXONVU1QDF7OUG=
mouse L5178 cells MlzNSpVv[3Srb36gZZN{[Xl? MV2yNEBucW6| NFPDeYhKdmirYnn0bY9vKG:oIHj1cYFvKEGEQ1KxMY1m\GmjdHXkJJJpd2SjbXnu[UAyOjNiZX\mcJV5KGmwIH3veZNmKEx3MUe4JINmdGy|IHX4dJJme3OrbnegbJVu[W5iTVTSNUBi\nSncjCyNEBucW6|IHL5JGZCS1NiYX7hcJl{cXNuIFnDOVA:OC54NTFOwG0> MYWyNVM1OTd2NR?=
LLC-PK1 epithelial cells NELhb|FHfW6ldHnvckBie3OjeR?= NFq0epdKdmirYnn0bY9vKG:oIGCt[4x6[2:ycn;0[YlvNCCvb4Xz[UBNNW2mckHiJIV5eHKnc4Pl[EBqdiCOTFOtVGsyKGWyaYTo[Yxq[WxiY3XscJMhfXOrbnegZ4Ft[2Wrbj3BUUBxd2yjcnnzZZRqd25iYYPzZZnwxIxiSVO1NF0xNjdizszN M2HRd|EzPjl7M{i5
human K562/R7 cells MoDrSpVv[3Srb36gZZN{[Xl? MmPJNUDPxE1? NHz5Upc4OiCq MVXQc5RmdnSrYYTpc44hd2ZiZH;4c5J2[mmlaX6tbY5lfWOnZDDjfZRwfG:6aXPpeJkh[WejaX7zeEBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUzV4Mj;SO{Bk\WyuczDhd5Nme3OnZDDhd{Bld3ixcoXibYNqdiCLQ{WwJIF1KDFidV2gZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1yLkeg{txO NXjlN3dvOjV4M{SwOFE>
A2780/ADR cells NULGOGlLTnWwY4Tpc44h[XO|YYm= M3zvd2lvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4h\XiycnXzd4VlKGmwIFGyO|gxN0GGUjDj[YxteyCkeTDjZYxk\WmwIFHNJIF{e2G778{MJGlEPTB;MT60NVI2PCEQvF2= NInofVEyPzh7MEC5OC=>
KB/MDR cell Ml:xSpVv[3Srb36gZZN{[Xl? MknMO|IhcA>? M371emlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBMSi:PRGKgZ4VtdCCuaX7lJIFnfGW{IEeyJIhzKG:oIHTyeYch\Xiyb4P1doUtKEmFNUC9NU42KM7:TR?= NFnze5MyPTR6MUm5NS=>
guinea pig ventricular myocytes MnLISpVv[3Srb36gZZN{[Xl? NV\xb5ZFUW6qaXLpeIlwdiCxZjDMMZR6eGViY3HsZ4l2dSClaHHucoVtKG2nYYP1doVlKHW|aX7nJJdpd2ynLXPlcIwheGG2Y3igZ4xidXBiaX6g[5VqdmWjIIDp[{B3\W62cnnjeYxieiCveX;jfZRmeyxiSVO1NF0zKM7:TR?= NIDIcIgzOjd4MUCwNC=>
human MDA435/LCC6MDR cells M3jieWN6fG:2b4jpZ:Kh[XO|YYm= M33XNVczcA>? NIHvVFVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEF2M{WvUGNEPk2GUjDj[YxteyCneIDy[ZN{cW6pIF3EVkBi\nSncjC3NkBpenQxvJygTWM2OD1{Lkig{txO NWXuSHp7OjJ|MkC0NFI>
human Caco2 cells MmrrSpVv[3Srb36gZZN{[Xl? M2HwbY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJGNi[29{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBlcWexeHnuJIVn\my3eDygTWM2OD1{Lkmg{txO M4LZVlI{Ozh{NEW4
leukemia CEM cells NIGzW4JHfW6ldHnvckBie3OjeR?= MnHiTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIF3EVlEhWC2JbInjc5Bzd3SnaX6gRWJEKFS{YX7zdI9zfGW{IIXzbY5oKGyndXvlcYliKEOHTTDj[YxteyxiSVO1NF0{NjRizszN MYexNlM3OTN6Nx?=
human HeLa cells NF3mVnFHfW6ldHnvckBie3OjeR?= M33QWGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGhRXi1zODDpcoZm[3SnZDDpckBpfW2jbjDI[WxiKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiNzDkZZl{97zOIGTDOVA:PC54IN88US=> MXGxPFIyOjFyMB?=
human 2008 cells MlLZSpVv[3Srb36gZZN{[Xl? Mn7zTY5pcWKrdHnvckBw\iCqdX3hckBOWlBzIHnuJIh2dWGwIEKwNFgh[2WubIOsJGlEPTB;ND63PEDPxE1? NHH5UWwyQDdyN{i4OC=>
human HuH7 cells NHPQVVVEgXSxdH;4bYPDqGG|c3H5 NEnvNYREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfUh5IHPlcIx{KGG|c3Xzd4VlKGG|IILlcIVie2Vib3[gcIFkfGG2ZTDk[Yh6\HKxZ3XuZZNmNCCLQ{WwQVUvQDFizszN M3jRflIxQTR|M{mw
human Huh5-2 cells M2Pt[2N6fG:2b4jpZ:Kh[XO|YYm= M2X0OVMh\GG7cx?= MnjCR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVpPS1{IHPlcIx{KGGodHXyJFMh\GG7czDifUBOXFRiYYPzZZkhNCCFQ{WwQVYh|ryP MmTYNVg3OjV5Nk[=
human HuH6 cells M2n2dWN6fG:2b4jpZ:Kh[XO|YYm= NFu0eW8{KGSjeYO= M4HmeGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2UDZiY3XscJMh[W[2ZYKgN{Bl[Xm|IHL5JG1VXCCjc4PhfUwhS0N3ME23JO69VQ>? MWSxPFYzPTd4Nh?=
human Huh-9-13 cells NHvtZnhEgXSxdH;4bYPDqGG|c3H5 NF\Zdmw{KGSjeYO= NXy0W5c4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWqLUmtNVMh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IF3UWEBie3Ojef-8kEBESzVyPUeg{txO M1jSfVE5PjJ3N{[2
african green monkey Vero cells MYPGeY5kfGmxbjDhd5NigQ>? NGLBRVgzPCCq NGfYS4dCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBY\XO2IF7pcIUhfmm{dYOgbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC4aYLhcEBTVkFic4nueIhme2m|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;ODFOwG0> NXTRWmhPOTl2NUGyPFY>
human HeLa cells MW\DfZRwfG:6aXRCpIF{e2G7 MUTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzMEBVSzVyPUiuN{DPxE1? NUfPeHpZOTh{MUKxNFA>
human LCC-6 cells MlOwR5l1d3SxeHnjxsBie3OjeR?= M{fJXFczKGh? MXjDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMR2MuPiClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:QC5|IN88US=> NWroXFhvOjJ|MkC0NFI>
MDCK cells MUnDfZRwfG:6aXRCpIF{e2G7 NFTFfJNEgXSxdH;4bYNqfHliYXfhbY5{fCCPRFPLJINmdGy|LDDUR|UxRTlwOTFOwG0> MUmxPFIyOjFyMB?=
human Huh-Mono cells M3fKb2N6fG:2b4jpZ:Kh[XO|YYm= M3rJ[lMh\GG7cx?= M1PDb2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2cC2Pb37vJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XoxvJygR2M2OD1{NDFOwG0> NW\0VYxHOTh4MkW3OlY>
mouse L929 cells MXnDfZRwfG:6aXRCpIF{e2G7 MWmzJIRigXN? Mm\sR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUFkzQSClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRUKGG|c3H5MEBKSzVyPUOwJO69VQ>? MXKyOVk5PTF7NR?=
rat H42E cells MoPNR5l1d3SxeHnjxsBie3OjeR?= M3:5T2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KHKjdDDIOFJGKGOnbHzzJIF{e2W|c3XkJIF{KGmwdILhZ4VtdHWuYYKgRXRRKGyndnXsMEBVSzVyPUSyJO69VQ>? MmrhNVk2ODJyNUi=

... Click to View More Cell Line Experimental Data

In vivo Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs. [6], is clinically used in organ transplantation to prevent rejection. [7]

Protocol

Kinase Assay:[3]
+ Expand

Phosphatase Assay:

Purified bovine brain calcineurin and calmodulin are purchased. Reaction mixtures with purified enzyme contains 100 nM calcineurin, 100 nM calmodulin, and 5 μM 32P-labeled phosphopeptide, in 60 μl (total volume) of assay buffer containing 20 mM Tris (pH 8), 100 mM NaCI, 6 mM MgCl2, 0.5 mM dithiothreitol, 0.1 mg of bovine serum albumin per ml, and either 0.1 mM CaCl2 or 5 mM EGTA. Reaction mixtures with cell lysates contains 20 μl of undiluted lysate, 5 μM 32P-labeled phosphopeptide, and 40 μl of assay buffer. Where indicated, reaction mixtures contains 50 μM peptide 412 or 413 and/or 500 nM okadaic acid, a specific inhibitor of phosphatases 1 and 2A; 500 nM okadaic acid is sufficient for inhibition of Ca2+-independent phosphatases, whereas higher concentrations partially inhibit Ca2+-dependent activity as well. After 15 min at 30°C, reactions are terminated by the addition of 0.5 ml of 100 mM potassium phosphate buffer (pH 7.0) containing 5% trichloroacetic acid. Free inorganic phosphate is isolated by Dowex cation-exchange chromatography and quantitated by scintillation counting as described.
Cell Research:[3]
+ Expand
  • Cell lines: Jurkat cells (clone J77)
  • Concentrations: ~100 nM
  • Incubation Time: 1 hr
  • Method: Immunosuppressive agents are dissolved in ethanol at concentrations 1000-fold more than the concentration desired for cell treatments. Cells (106) are suspended in 1 ml of complete medium in microcentrifuge tubes; 1 μl of ethanol or of the ethanolic solution of Cyclosporin A is added, and the cells are incubated at 37°C for 1 hr. Cells are washed twice with 1 ml of PBS on ice and lysed in 50μl of hypotonic buffer containing 50 mM Tris (pH 7.5); 0.1 mM EGTA; 1 mM EDTA; 0.5 mM dithiothreitol; and 50 μg of phenylmethylsulfonyl fluoride, 50 μg of soybean trypsin inhibitor, 5 μg of leupeptin, and 5 μg of aprotinin per ml. Lysates are subjected to three cycles of freezing in liquid nitrogen followed by thawing at 30°C and then are centrifuged at 4°C for 10 min at 12,000×g.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Rat
  • Formulation: 0.5% solution of tragacanth
  • Dosages: 45 mg/kg
  • Administration: orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (83.15 mM)
Ethanol 100 mg/mL warmed (83.15 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1202.61
Formula

C62H111N11O12

CAS No. 59865-13-3
Storage powder
in solvent
Synonyms Cyclosporine A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04023760 Recruiting Drug: Apixaban Pharmacokinetics|Kidney Transplant|Lung Transplant University of Saskatchewan|Saskatchewan Health Research Foundation|Lung Association of Saskatchewan June 26 2019 Phase 4
NCT03865888 Completed Drug: Cyclosporins|Drug: Tacrolimus Dry Eye|Sjogren Syndrome Pavly Moawd|Cairo University October 30 2018 Phase 3
NCT01762657 Withdrawn Drug: Oral Cyclosporine and Oral Lansoprazole|Drug: Placebos Type 1 Diabetes Perle Bioscience Inc. September 2014 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What is the difference between S2286 (cyclosporin A) and S1514 (cyclosporin)?

  • Answer:

    Cyclosporine is a mixture of Cyclosporine A, derivatives of Cyclosporine A, salts of Cyclosporine A. Cyclosporine A is an especially useful Cyclosporine component.

Tags: buy Cyclosporin A | Cyclosporin A supplier | purchase Cyclosporin A | Cyclosporin A cost | Cyclosporin A manufacturer | order Cyclosporin A | Cyclosporin A distributor
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID