Cyclosporin A

Catalog No.S2286 Synonyms: Cyclosporine A

Cyclosporin A  Chemical Structure

Molecular Weight(MW): 1202.61

Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.

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In DMSO USD 130 In stock
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  • Repression of BSEP gene expression upon treatment with reported BSEP inhibitors in human primary hepatocytes. BSEP mRNA expression was measured using real-time PCR in hepatocytes from at least three donors upon treatment with BSEP inhibitors as described under Materials and Methods. All the data are expressed as mean ?S.D. (n = 3).

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

    Immunophilins participate in SOCE activation by CN-dependent but also CN-independent signaling pathways. Fura-2 loaded platelets were suspended in HBS, platelets are incubated for 5 min with cyclosporin A (CsA, 50 µM). Once incubation time was over, platelets were stimulated with TG (200 nM) in a calcium free-HBS (EGTA 100 μM was added as indicated the by arrowhead) and 4 min later CaCl2 (300 µM) was added to visualized calcium entry. Changes in fura-2 fluorescence were monitored using the 340/380nm ratio and calibrated in terms of [Ca2+]c . Traces are representative of four to six independent experiments. *,**, *** represents p < 0.05, p < 0.01 and p <0.001, respect control platelets.

    Biochim Biophys Acta 2013 1833(3), 652-62. Cyclosporin A purchased from Selleck.

  • CsA and FTY720 suppress HFD-induced hepatic fat accumulation. Mice were sacrificed at the end of experiment and liver samples were freshly collected and processed. (a) Representative images of liver samples with H&E staining. (b) Representative images of liver samples with Oil Red O staining. Scale bars represent 100 µm.

    Pharm Res, 2016, 33(2):395-403. Cyclosporin A purchased from Selleck.

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Biological Activity

Description Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.
Targets
calcineurin [1]
(Cell-free assay)
7 nM
In vitro

Cyclosporin A binds to the cyclophilin (immunophilin) in T cells[1] , forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. [2] Cyclosporin A inhibits calcineurin with IC50 of 7 nM[3], then blocks the nuclear translocation of NF-AT. [4] Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 cells M{D2WmZ2dmO2aX;uJIF{e2G7 MoTzTY5pcWKrdHnvckBw\iCuaY\ldkB{fGGpZTDQcIF{dW:maYXtJIJmemeqZXmgbY5n\WO2aX;uJIlvKEincFeyJINmdGy|LDDJR|UxRTFwNkWgcm0> NX30dJdqOjJ3OE[xNlQ>
Jurkat cells MXHGeY5kfGmxbjDhd5NigQ>? NIPHOoxKdW23bn;zeZBxemW|c3n2[UBi[3Srdnn0fUB4[XNibXXhd5Vz\WRiYomgbY5pcWKrdHnvckBw\iC2aHWgTWwuOiCycn;keYN1cW:wIHnuJGp2emujdDDj[YxteyxiSVO1NF0zKG6P MlzhNVQ3PDN|M{e=
human PBMC M3[zcGZ2dmO2aX;uJIF{e2G7 MUKxJIg> NYjnWJBlSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCqdX3hckBRSk2FIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiYX70bU1ETDNxQ1SyPEBidnSrYn;kfU1qdmS3Y3XkJGlNNTJicILv[JVkfGmxbjD0doVifGWmIH\vdkAyKGi{IHLl[o9z\SCjboTpMWNFOy:FREK4JIFvfGmkb3T5JINp[WyuZX7n[UBu\WG|dYLl[EBi\nSncjC2JIhzeyCkeTDpcY12dm:|dYDwdoV{e2mxbjDhd5NigSxiRVO1NF0{NjFibl2= MoHvNVk6OzN5OUW=
human Jurkat cells NEHISZdHfW6ldHnvckBie3OjeR?= MWOxJIg> MVLBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIFr1dotifCClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIFvfGlvQ1SzM2NFOjhiYX70bYJw\HlvaX7keYNm\CCLTD2yJJBzd2S3Y4Tpc44hfHKnYYTl[EBnd3JiMTDodkBj\W[xcnWgZY51cS2FREOvR2QzQCCjboTpZo9lgSClaHHscIVv\2VibXXhd5Vz\WRiYX\0[ZIhPiCqcoOgZpkhcW2vdX7vd5VxeHKnc4Ppc44h[XO|YYmsJGVEPTB;NTDuUS=> MXKxPVk{Ozd7NR?=
human T-cell MXnGeY5kfGmxbjDhd5NigQ>? MoXCTY4hfmm2cn:gbY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGStZ4VtdCCycn;keYN1cW:wIH;mJIx6dXCqb3vpcoUhUUxvMjygTWM2OD16LkGgcm0> NY\ISo5JPzV|N{OzNS=>
human splenocytes M{HCSmZ2dmO2aX;uJIF{e2G7 NYm0[lFTPCCmYYnz M2W2O2ludXWwb4P1dJBz\XO|aY\lJIFkfGm4aYT5JIlvKGi3bXHuJJNxdGWwb3P5eIV{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhYzOKXYTofY1q\GmwZTDpcoNwenCxcnH0bY9vKGGodHXyJFQh\GG7czDifUBidGyxZ3XubYMhdWm6ZXSgcJlueGixY4n0[UBz\WGldHnvckBie3OjeTygTWM2OD1zMDDuUS=> MnXhNVk5Ojd6M{G=
mouse T cells M4\LNGZ2dmO2aX;uJIF{e2G7 M2fTfFQh\GG7cx?= MnzmTY1ufW6xc4XwdJJme3OrdnWgZYN1cX[rdImgbY4hdW:3c3WgWEBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIIT3c{B4[XlibXn4[YQhdHmvcHjvZ5l1\SC{ZXHjeIlwdiCjZoTldkA1KGSjeYOgZpkhVVSWIHHzd4F6NCCrY{WwQVEyKG6P M4\CPVIzQTh2OUi3
human PBMC MoPiVJJwdGmoZYLheIlwdiCjc4PhfS=> NHi5cm9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDCUWMtKEmFNUC9NVIhdk1? NETLdJkyPTZ5OUOwPS=>
human MDA435/LCC6MDR cells MVTGeY5kfGmxbjDhd5NigQ>? NHPYZZU2KGSjeYO= NX\rVWYzVW:mdXzheIlwdiCxZjDQMYdxKCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gbJVu[W5iTVTBOFM2N0yFQ{\NSHIh[2WubIOgZZN{\XO|ZXSgZZMhemW4ZYLzbY5oKHCjY3zpeIF5\WxicnXzbZN1[W6lZTDt[YF{fXKnZDDhd{Bk\WyuIIP1dpZqfmGuIHHmeIVzKDViZHH5d{BjgSCPVGOgZZN{[XluIFXDOVA:OC5yM{Kg{txONg>? NIHxR2QzPTl6NUG5OS=>
HEK293 cells NVTMSoY4TnWwY4Tpc44h[XO|YYm= NWr6OI1MUW6qaXLpeIlwdiCxZjDPRXRROUJzIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDwdo91\WmwLX3l[IlifGWmIIDpeIF3[XO2YYTpckB2eHSja3ZvwKwhU2l;MD6yJO69VQ>? MkXUNlI2QDd7OE[=
CK1 cells NYq4XoF[TnWwY4Tpc44h[XO|YYm= MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDIVHYuOzNiaX7m[YN1\WRiaX6gR2syKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiNzDkZZl{NCCWQ{WwQVAvOyEQvF2= MVuxPFIyOjFyMB?=
mouse mammary carcinoma cell line EMT6/AR 1.0 MV;GeY5kfGmxbjDhd5NigQ>? M37GNnJmfmW{c3HsJIVn\mWldDDvckB1cGViYXPjeY12dGG2aX;uJI9nKFt|SG2tJIRifW6xcoXibYNqdiCrbjDtc5V{\SCvYX3tZZJ6KGOjcnPpco9u[SClZXzsJIxqdmViRV3UOk9CWiBzLkCsJGlEPTB;MD60OEDPxE1? NEW4W|kyODB7OE[3NS=>
KB cell NYX2Rm1CTnWwY4Tpc44h[XO|YYm= NEPXTVRKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhU0JiY3XscEBtcW6nIHHmeIVzKDd{IHigc4Yh\HK3ZzDlfJBwe3W{ZTygTWM2OD1yLk[g{txO MmXVNVU1QDF7OUG=
mouse L5178 cells M1foTGZ2dmO2aX;uJIF{e2G7 MmnnNlAhdWmwcx?= MVXJcohq[mm2aX;uJI9nKGi3bXHuJGFDS0JzLX3l[IlifGWmIILoc4RidWmwZTCxNlMh\W[obIX4JIlvKG2xdYPlJGw2OTd6IHPlcIx{KGW6cILld5NqdmdiaIXtZY4hVUSUMTDh[pRmeiB{MDDtbY5{KGK7IF\BR3Mh[W6jbInzbZMtKEmFNUC9NE43PSEQvF2= MlHWNlE{PDF5NEW=
LLC-PK1 epithelial cells M4jmeGZ2dmO2aX;uJIF{e2G7 MmiwTY5pcWKrdHnvckBw\iCSLXfsfYNweHKxdHXpckwhdW:3c3WgUE1u\HJzYjDlfJBz\XO|ZXSgbY4hVEyFLWDLNUBmeGm2aHXsbYFtKGOnbHzzJJV{cW6pIHPhcINmcW5vQV2gdI9t[XKrc3H0bY9vKGG|c3H589yNKEmFNUC9NE44KM7:TR?= MWmxNlY6QTN6OR?=
human K562/R7 cells NEDoS5NHfW6ldHnvckBie3OjeR?= NHSz[WsyKM7:TR?= MmjKO|IhcA>? NXnHR4Q5WG:2ZX70bYF1cW:wIH;mJIRwgG:{dXLpZ4lvNWmwZIXj[YQh[3m2b4TvfIlkcXS7IHHnZYlve3RiZH;4c5J2[mmlaX6tdoV{cXO2YX70JIh2dWGwIFu1OlIwWjdiY3XscJMh[XO|ZYPz[YQh[XNiZH;4c5J2[mmlaX6gTWM2OCCjdDCxJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE44KM7:TR?= NXfDNYRnOjV4M{SwOFE>
A2780/ADR cells MmXNSpVv[3Srb36gZZN{[Xl? M1zaXGlvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4h\XiycnXzd4VlKGmwIFGyO|gxN0GGUjDj[YxteyCkeTDjZYxk\WmwIFHNJIF{e2G778{MJGlEPTB;MT60NVI2PCEQvF2= M171UVE4QDlyMEm0
KB/MDR cell NEe4do9HfW6ldHnvckBie3OjeR?= Mn;VO|IhcA>? MVTJcohq[mm2b4L5JIFkfGm4aYT5JIFo[Wmwc4SgT2IwVUSUIHPlcIwhdGmwZTDh[pRmeiB5MjDodkBw\iCmcoXnJIV5eG:|dYLlMEBKSzVyPUGuOUDPxE1? M4SyVlE2PDhzOUmx
guinea pig ventricular myocytes MVHGeY5kfGmxbjDhd5NigQ>? MlLjTY5pcWKrdHnvckBw\iCOLYT5dIUh[2GuY3n1cUBkcGGwbnXsJI1m[XO3cnXkJJV{cW6pIIfoc4xmNWOnbHygdIF1[2hiY3zhcZAhcW5iZ4XpcoViKHCrZzD2[Y51emmldXzhdkBugW:leYTld{whUUN3ME2yJO69VQ>? NHnlVYEzOjd4MUCwNC=>
human MDA435/LCC6MDR cells MlLOR5l1d3SxeHnjxsBie3OjeR?= MoTnO|Jp Mn70R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCPDN3L1zDR|ZOTFJiY3XscJMh\XiycnXzd4lv\yCPRGKgZYZ1\XJiN{KgbJJ{97zOIFnDOVA:Oi56IN88US=> NUHzU5IzOjJ|MkC0NFI>
human Caco2 cells NX\remc5TnWwY4Tpc44h[XO|YYm= Mkjzcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gR4FkdzJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJIRq\2:6aX6g[YZndHW6LDDJR|UxRTJwOTFOwG0> MoPwNlM{QDJ2NUi=
leukemia CEM cells Ml;CSpVv[3Srb36gZZN{[Xl? MmjuTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIF3EVlEhWC2JbInjc5Bzd3SnaX6gRWJEKFS{YX7zdI9zfGW{IIXzbY5oKGyndXvlcYliKEOHTTDj[YxteyxiSVO1NF0{NjRizszN M{jZe|EzOzZzM{i3
human HeLa cells NHPHXlNHfW6ldHnvckBie3OjeR?= NFuxU45CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBJWFZvMUigbY5n\WO2ZXSgbY4hcHWvYX6gTIVN[SClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEeg[IF6e+,:jDDUR|UxRTRwNjFOwG0> MUKxPFIyOjFyMB?=
human 2008 cells MWfGeY5kfGmxbjDhd5NigQ>? MYfJcohq[mm2aX;uJI9nKGi3bXHuJG1TWDFiaX6gbJVu[W5iMkCwPEBk\WyuczygTWM2OD12Lke4JO69VQ>? MYqxPFcxPzh6NB?=
human HuH7 cells NG\hTpFEgXSxdH;4bYPDqGG|c3H5 Ml7qR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTJVJPyClZXzsd{Bie3Onc4Pl[EBieyC{ZXzlZZNmKG:oIHzhZ5RifGViZHXofYRzd2enbnHz[UwhUUN3ME21MlgyKM7:TR?= NIHUU|gzODl2M{O5NC=>
human Huh5-2 cells MkK2R5l1d3SxeHnjxsBie3OjeR?= NH[4TJY{KGSjeYO= M4DTVGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2cDVvMjDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6KCxiQ1O1NF03KM7:TR?= MXmxPFYzPTd4Nh?=
human HuH6 cells MV;DfZRwfG:6aXRCpIF{e2G7 MYKzJIRigXN? NXv4PVhKS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUHWKNjDj[YxteyCjZoTldkA{KGSjeYOgZpkhVVSWIHHzd4F6NCCFQ{WwQVch|ryP M1;3dFE5PjJ3N{[2
human Huh-9-13 cells M3HGSmN6fG:2b4jpZ:Kh[XO|YYm= M1O4WVMh\GG7cx?= M1vjbmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGh2cC17LUGzJINmdGy|IHHmeIVzKDNiZHH5d{BjgSCPVGSgZZN{[XoxvJygR2M2OD15IN88US=> M{nDR|E5PjJ3N{[2
african green monkey Vero cells MnzHSpVv[3Srb36gZZN{[Xl? NXH5elJmOjRiaB?= NF7YTGZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBY\XO2IF7pcIUhfmm{dYOgbY5n\WO2ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC4aYLhcEBTVkFic4nueIhme2m|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;ODFOwG0> MnOwNVk1PTF{OE[=
human HeLa cells NYe0cY1XS3m2b4TvfIlkyqCjc4PhfS=> MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDI[WxiKGOnbHzzMEBVSzVyPUiuN{DPxE1? MXexPFIyOjFyMB?=
human LCC-6 cells MkfLR5l1d3SxeHnjxsBie3OjeR?= MWe3NkBp MV7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMR2MuPiClZXzsd{Bi\nSncjC3NkBpenNuIFnDOVA:QC5|IN88US=> NHy4TJgzOjN{MESwNi=>
MDCK cells M3ywbmN6fG:2b4jpZ:Kh[XO|YYm= NVHjRZJJS3m2b4TvfIlkcXS7IHHnZYlve3RiTVTDT{Bk\WyuczygWGM2OD17Lkmg{txO MlK0NVgzOTJzMEC=
human Huh-Mono cells M13vW2N6fG:2b4jpZ:Kh[XO|YYm= NInOXVU{KGSjeYO= NH;JV|lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJfWhvTX;uc{Bk\WyuczDh[pRmeiB|IHThfZMh[nliTWTUJIF{e2G778{MJGNEPTB;MkSg{txO M2W5OlE5PjJ3N{[2
mouse L929 cells MoHCR5l1d3SxeHnjxsBie3OjeR?= NVXreYs6OyCmYYnz MmTxR5l1d3SxeHnjbZR6KGGpYXnud5QhdW:3c3WgUFkzQSClZXzsd{Bi\nSncjCzJIRigXNiYomgUXRUKGG|c3H5MEBKSzVyPUOwJO69VQ>? MoD6NlU6QDVzOUW=
rat H42E cells M1TkbWN6fG:2b4jpZ:Kh[XO|YYm= M{T4T2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KHKjdDDIOFJGKGOnbHzzJIF{e2W|c3XkJIF{KGmwdILhZ4VtdHWuYYKgRXRRKGyndnXsMEBVSzVyPUSyJO69VQ>? NUDXe4RjOTl3MEKwOVg>

... Click to View More Cell Line Experimental Data

In vivo Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs. [6], is clinically used in organ transplantation to prevent rejection. [7]

Protocol

Kinase Assay:[3]
+ Expand

Phosphatase Assay:

Purified bovine brain calcineurin and calmodulin are purchased. Reaction mixtures with purified enzyme contains 100 nM calcineurin, 100 nM calmodulin, and 5 μM 32P-labeled phosphopeptide, in 60 μl (total volume) of assay buffer containing 20 mM Tris (pH 8), 100 mM NaCI, 6 mM MgCl2, 0.5 mM dithiothreitol, 0.1 mg of bovine serum albumin per ml, and either 0.1 mM CaCl2 or 5 mM EGTA. Reaction mixtures with cell lysates contains 20 μl of undiluted lysate, 5 μM 32P-labeled phosphopeptide, and 40 μl of assay buffer. Where indicated, reaction mixtures contains 50 μM peptide 412 or 413 and/or 500 nM okadaic acid, a specific inhibitor of phosphatases 1 and 2A; 500 nM okadaic acid is sufficient for inhibition of Ca2+-independent phosphatases, whereas higher concentrations partially inhibit Ca2+-dependent activity as well. After 15 min at 30°C, reactions are terminated by the addition of 0.5 ml of 100 mM potassium phosphate buffer (pH 7.0) containing 5% trichloroacetic acid. Free inorganic phosphate is isolated by Dowex cation-exchange chromatography and quantitated by scintillation counting as described.
Cell Research:[3]
+ Expand
  • Cell lines: Jurkat cells (clone J77)
  • Concentrations: ~100 nM
  • Incubation Time: 1 hr
  • Method: Immunosuppressive agents are dissolved in ethanol at concentrations 1000-fold more than the concentration desired for cell treatments. Cells (106) are suspended in 1 ml of complete medium in microcentrifuge tubes; 1 μl of ethanol or of the ethanolic solution of Cyclosporin A is added, and the cells are incubated at 37°C for 1 hr. Cells are washed twice with 1 ml of PBS on ice and lysed in 50μl of hypotonic buffer containing 50 mM Tris (pH 7.5); 0.1 mM EGTA; 1 mM EDTA; 0.5 mM dithiothreitol; and 50 μg of phenylmethylsulfonyl fluoride, 50 μg of soybean trypsin inhibitor, 5 μg of leupeptin, and 5 μg of aprotinin per ml. Lysates are subjected to three cycles of freezing in liquid nitrogen followed by thawing at 30°C and then are centrifuged at 4°C for 10 min at 12,000×g.
    (Only for Reference)
Animal Research:[6]
+ Expand
  • Animal Models: Rat
  • Formulation: 0.5% solution of tragacanth
  • Dosages: 45 mg/kg
  • Administration: orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL warmed (83.15 mM)
Ethanol 100 mg/mL warmed (83.15 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1202.61
Formula

C62H111N11O12

CAS No. 59865-13-3
Storage powder
in solvent
Synonyms Cyclosporine A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02496975 Withdrawn Traumatic Brain Injury Edward HallPhD|University of Kentucky August 7 2017 Phase 1|Phase 2
NCT03013933 Recruiting Recurrent Hodgkin Lymphoma|Refractory Hodgkin Lymphoma|CD30-Positive Neoplastic Cells Present City of Hope Medical Center|National Cancer Institute (NCI) May 3 2017 Phase 1
NCT03657342 Not yet recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. January 2019 Phase 3
NCT03656926 Not yet recruiting Bronchiolitis Obliterans Breath Therapeutics Inc. January 2019 Phase 3
NCT02987257 Not yet recruiting Stevens-Johnson Syndrome|Toxic Epidermal Necrolyses Ottawa Hospital Research Institute|Canadian Dermatology Foundation|Vanderbilt University Medical Center|Brooke Army Medical Center August 2018 Phase 3
NCT02887807 Not yet recruiting Shockable Out of Hospital Cardiac Arrest Hospices Civils de Lyon January 2017 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What is the difference between S2286 (cyclosporin A) and S1514 (cyclosporin)?

  • Answer:

    Cyclosporine is a mixture of Cyclosporine A, derivatives of Cyclosporine A, salts of Cyclosporine A. Cyclosporine A is an especially useful Cyclosporine component.

Tags: buy Cyclosporin A | Cyclosporin A supplier | purchase Cyclosporin A | Cyclosporin A cost | Cyclosporin A manufacturer | order Cyclosporin A | Cyclosporin A distributor
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID