Cilostazol

Name: Cilostazol
Brand: Selleck Chemicals
SKU: S1294
Rating: 5 (4 reviews)

For research use only.

Catalog No.S1294 Synonyms: OPC-13013

4 publications

CAS No. 73963-72-1

Cilostazol (OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Selleck's Cilostazol has been cited by 4 publications

Int J Biol Sci, 2020, 27;16(11):2001-2013

PubMed: 32398966 ( click the link to review the publication )

Mol Cell, 2019, 75(6):1103-1116.e9

PubMed: 31420216 ( click the link to review the publication )

FASEB J, 2019, 10.1096/fj.201900326R

PubMed: 31184927 ( click the link to review the publication )

Am J Cancer Res, 2019, 9(9):1905-1921

PubMed: 31598394 ( click the link to review the publication )

Purity & Quality Control

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Biological Activity

Description

Cilostazol (OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Targets

PDE3 ^[4]

0.2 μM

In vitro

Cilostazol (OPC-13013) is a 2-oxo-quinoline derivative with antithrombotic, vasodilator, antimitogenic and cardiotonic properties. The vasodilatory and antiplatelet actions of cilostazol are due mainly to the inhibition of phosphodiesterase 3 (PDE3) and subsequent elevation of intracellular cAMP levels. Cilostazol inhibits platelet aggregation. ^[1] Cilostazol also possesses the ability to inhibit adenosine uptake. ^[3] Elevation of interstitial adenosine by cilostazol in the heart is shown to reduce increases in cAMP caused by the PDE3-inhibitory action of cilostazol, thus attenuating the cardiotonic effects. Cilostazol is reported to inhibit smooth muscle cell proliferation. ^[2] Cilostazol relaxes vascular smooth muscle and causes vasodilatation. Cilostazol inhibits the cytokine-induced expression of monocyte chemoattractant protein-1 (MCP-1). Cilostazol reduced plasma triglycerides and raised plasma HDL-cholesterol . ^[4]

Protocol

References

[4] Schr?r K. et al. Diabetes Obes Metab, 2002, 4 Suppl 2, S14- S19.

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Solubility (25°C)

In vitro	DMSO	74 mg/mL (200.29 mM)
	Ethanol	6 mg/mL warmed (16.23 mM)
	Water	Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Cilostazol SDF

Molecular Weight	369.46
Formula	C₂₀H₂₇N₅O₂
CAS No.	73963-72-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	OPC-13013
Smiles	C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4

In vivo Formulation Calculator (Clear solution)

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

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The Serial Dilution Calculator Equation

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Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03156920	Completed	Drug: Placebo\|Drug: Sumatriptan	Migraine	Danish Headache Center	May 23 2017	Not Applicable
NCT02625714	Completed	Drug: Renexin®\|Drug: SID142	Arterial Occlusive Diseases	SK Chemicals Co. Ltd.	June 2015	Phase 1
NCT02374957	Terminated	Drug: Cilostazol	Peripheral Arterial Disease\|Claudication (Finding)	Wake Forest University Health Sciences	February 2015	Phase 4
NCT02098460	Unknown status	Drug: Atorvastatin Probucol Cilostazol	Severe Hypercholesterolemia	Otsuka Beijing Research Institute	October 2013	Phase 4
NCT01841827	Completed	Drug: Cilostazol\|Drug: Placebo	Migraine	Danish Headache Center	April 2013	Not Applicable
NCT00886574	Unknown status	Drug: Cilostazol\|Drug: Aspirin	Type 2 Diabetes Mellitus	Hanyang University\|Ajou University School of Medicine\|Kyunghee University Medical Center\|Korea University Guro Hospital\|Inha University Hospital\|Inje University\|Hallym University Medical Center	April 2009	Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cilostazol