For research use only.
CAS No. 73963-72-1
Cilostazol (OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
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|Description||Cilostazol (OPC-13013) is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.|
Cilostazol (OPC-13013) is a 2-oxo-quinoline derivative with antithrombotic, vasodilator, antimitogenic and cardiotonic properties. The vasodilatory and antiplatelet actions of cilostazol are due mainly to the inhibition of phosphodiesterase 3 (PDE3) and subsequent elevation of intracellular cAMP levels. Cilostazol inhibits platelet aggregation.  Cilostazol also possesses the ability to inhibit adenosine uptake.  Elevation of interstitial adenosine by cilostazol in the heart is shown to reduce increases in cAMP caused by the PDE3-inhibitory action of cilostazol, thus attenuating the cardiotonic effects. Cilostazol is reported to inhibit smooth muscle cell proliferation.  Cilostazol relaxes vascular smooth muscle and causes vasodilatation. Cilostazol inhibits the cytokine-induced expression of monocyte chemoattractant protein-1 (MCP-1). Cilostazol reduced plasma triglycerides and raised plasma HDL-cholesterol . 
|In vitro||DMSO||74 mg/mL (200.29 mM)|
|Ethanol||'6 mg/mL warmed|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03156920||Completed||Drug: Placebo|Drug: Sumatriptan||Migraine||Danish Headache Center||May 23 2017||Not Applicable|
|NCT02625714||Completed||Drug: Renexin®|Drug: SID142||Arterial Occlusive Diseases||SK Chemicals Co. Ltd.||June 2015||Phase 1|
|NCT02374957||Terminated||Drug: Cilostazol||Peripheral Arterial Disease|Claudication (Finding)||Wake Forest University Health Sciences||February 2015||Phase 4|
|NCT02098460||Unknown status||Drug: Atorvastatin Probucol Cilostazol||Severe Hypercholesterolemia||Otsuka Beijing Research Institute||October 2013||Phase 4|
|NCT01841827||Completed||Drug: Cilostazol|Drug: Placebo||Migraine||Danish Headache Center||April 2013||Not Applicable|
|NCT00886574||Unknown status||Drug: Cilostazol|Drug: Aspirin||Type 2 Diabetes Mellitus||Hanyang University|Ajou University School of Medicine|Kyunghee University Medical Center|Korea University Guro Hospital|Inha University Hospital|Inje University|Hallym University Medical Center||April 2009||Phase 4|
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