research use only

Cyclamic acid

Cat.No.S4015

Cyclamic acid (NSC 220327) in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners.
Cyclamic  acid Chemical Structure

Chemical Structure

Molecular Weight: 179.24

Quality Control

Batch: S401501 DMSO]36 mg/mL]false]Water]36 mg/mL]false]Ethanol]36 mg/mL]false Purity: 100%
100

Chemical Information, Storage & Stability

Molecular Weight 179.24 Formula

 

C6H13NO3S
Storage (From the date of receipt)
CAS No. 100-88-9 Download SDF Storage of Stock Solutions

Synonyms NSC 220327 Smiles C1CCC(CC1)NS(=O)(=O)O

Solubility

In vitro
Batch:

DMSO : 36 mg/mL ( (200.84 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 36 mg/mL

Ethanol : 36 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro
Cyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners in food and pharmaceuticals. Cyclamic acid is in use in more than 50 countries, especially in combination with other sweeteners, to eliminate aftertaste. However, the petition on Cyclamic acid, calcium and sodium cyclamate is being held in abeyance with the FDA in the USA (CFSAN - Office of Food Additive Safety, 2006).

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