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CC-99282 E3 ligase Ligand modulator

Name: CC-99282
Brand: Selleck Chemicals
SKU: E1212
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.E1212

CC-99282 (Golcadomide) is an orally active cereblon (CRBN) E3 ligase modulator (CELMoD). Ikaros and Aiolos are degraded potently and specifically by this compound, which co-opts CRBN.

CC-99282 E3 ligase Ligand modulator Chemical Structure

Quality Control

Batch: E121201 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.33%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

99.33

Related Targets	PROTAC Others Dyes Antineoplastic and Immunosuppressive Antibiotics ADC Cytotoxin Selection Antibiotics for Transfected Cell Antibiotics for Mammalian Cell Culture ADC Linker Molecular Glues Hydrotropic Agents
Featured Inhibitors	Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (186.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (9.34mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	535.57	Formula	C₂₈H₃₀FN₅O₅	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2379572-34-4	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Golcadomide			SMILES	FC1=C(CNC2=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=CC=C2)C=CC(=C1)CN5CC(C5)N6CCOCC6

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	E3 Ligase
References	[1] https://onlinelibrary.wiley.com/doi/10.1002/hon.89_2881

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-07)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05283720	ACTIVE_NOT_RECRUITING	Non-Hodgkin Lymphoma	Genmab	2022-06-14	PHASE2
NCT06835530	RECRUITING	Diffuse Large B Cell Non-Hodgkin Lymphoma	Fondazione Italiana Linfomi - ETS	2025-04-09	PHASE2
NCT05169515	ACTIVE_NOT_RECRUITING	Non-Hodgkin Lymphoma	Hoffmann-La Roche	2022-10-26	PHASE1
NCT04884035	ACTIVE_NOT_RECRUITING	Lymphoma, B-Cell	Celgene	2021-09-15	PHASE1
NCT06108232	RECRUITING	Follicular Lymphoma; Tumor	M.D. Anderson Cancer Center	2024-03-15	PHASE2
NCT03930953	ACTIVE_NOT_RECRUITING	Lymphoma, Non-Hodgkin	Celgene	2019-05-20	PHASE1; PHASE2

Tech Support

Handling Instructions

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