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Cefprozil hydrate

Cefprozil hydrate is a semi-synthetic broad-spectrum cephalosporin antibiotic, used to treat certain infections caused by bacteria, such as bronchitis and infections of the ears, throat, sinuses, and skin.

Cefprozil hydrate Chemical Structure

Cefprozil hydrate Chemical Structure

CAS: 121123-17-9

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Biological Activity

Description Cefprozil hydrate is a semi-synthetic broad-spectrum cephalosporin antibiotic, used to treat certain infections caused by bacteria, such as bronchitis and infections of the ears, throat, sinuses, and skin.
In vitro
In vitro Cefprozil is particularly active against the Gram-positive organisms Streptococcus pyogenes, pneumoniae and agalactiae and against methicillin-susceptible Staphylococcus aureus. Cefprozil is also moderately active against Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, many Enterobacteriaceae and certain anaerobic organisms, and is relatively stable to hydrolysis by a number of beta-lactamases. [1] Cefprozil is a newer oral Cephalosporin with a spectrum of activity against organisms that include gram-positive and gram-negative pathogens. Cefprozil is active (susceptibility, less than or equal to 8 mg /mL; moderate susceptibility, 16 mg/mL; resistance, greater than or equal to 32 mg/mL) against gram-positive species such as streptococci, methicillin-susceptible staphylococci, and Listeria monocytogenes. [2] Cefprozil is at least as active as cefuroxime, cefaclor, and cephalexin against all organisms tested, but is fourfold less active than doxycycline against E coli and 16-fold less active than clarithromycin versus S pneumoniae. Cefprozil is as active as amoxicillin/clavulanate against K pneumoniae and E coli. [3]
In Vivo
In vivo Cefprozil results in the mean peak concentration (Cmax) in infant dogs (21.2 mg/mL) and adult dogs (27.8 mg/mL). Cefprozil results in the areas under the concentration-time curve (AUC, in infant dogs: 121 mg.hr/mL, in adult dogs: 130 mg.hr/mL), half-lives (T 1/2, in infant dogs: 4.7 hours, in adult dogs: 4.7 hours) or urinary recovery rates (UR, in infant dogs: 36.3%, in adult dogs: 34.7%) between the 2 groups. [4]

Chemical Information & Solubility

Molecular Weight 407.44 Formula

C18H19N3O5S.H2O
CAS No. 121123-17-9 SDF Download Cefprozil hydrate SDF
Smiles CC=CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O.O
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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