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Cytochalasin D Actin Polymerization Inhibitor

Name: Cytochalasin D
Brand: Selleck Chemicals
SKU: S8184
Availability: InStock
Rating: 5 (7 reviews)

Cat.No.S8184

Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. Cytochalasin D inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap.

Chemical Structure

Molecular Weight: 507.62

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: Purity: 99.38%

99.38

Related Targets	Akt Microtubule Associated Wnt/beta-catenin HSP (HSP90) PKC Integrin Bcr-Abl FAK ROCK Kinesin PAK Dynamin MLCK MPS1 PORCN Gap-Junction Cardiac Myosin TACC3 Myosin
Related Products	CK-636 Benproperine phosphate

Chemical Information, Storage & Stability

Molecular Weight	507.62	Formula	C₃₀H₃₇NO₆	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	22144-77-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Zygosporin A, NSC 209835			Smiles	CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O

Solubility

In vitro
Batch:

DMSO : 25 mg/mL ( (49.24 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

References	https://pubmed.ncbi.nlm.nih.gov/6444302/ https://pubmed.ncbi.nlm.nih.gov/22728040/ https://pubmed.ncbi.nlm.nih.gov/22215811/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05091684	Recruiting	Hematological Patients\|Bleeding\|Platelet Refractoriness	Centre Hospitalier Universitaire de Saint Etienne\|Institut de Cancérologie de la Loire	February 10 2022	Phase 2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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