Home Ubiquitin E3 Ligase modulator CC-885 For research use only.

CC-885

CC-885 is a novel cereblon (CRBN) modulator. CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation.

CC-885 Chemical Structure

CC-885 Chemical Structure

CAS: 1010100-07-8

Purity & Quality Control

Batch: Purity: 99.96%
99.96

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Signaling Pathway

E3 Ligase Signaling Pathways

E3 Ligase Signaling Pathway

Choose Selective E3 Ligase Inhibitors

Biological Activity

Description

CC-885 is a novel cereblon (CRBN) modulator. CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation.
Targets
CRBN [1]
In vitro
In vitro

CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation in non-small-cell lung cancer (NSCLC) cells.<sup><a class="sref" href="#s_ref">[1]</a></sup>
Cell Research Cell lines A549, NCI-H1299
Concentrations 50 nM, 1 mM
Incubation Time 24 h, 48 h
Method

A549 and NCI-H1299 are treated with 1 mM CC-885 for 24 h and subjected to immunoblot analysis.
In Vivo
In vivo

CC-885 can promote PLK1 ubiquitination and degradation and synergistically inhibit NSCLC with volasertib in NSCLC model BALB/cA nude mice.<sup><a class="sref" href="#s_ref">[1]</a></sup>
Animal Research Animal Models NSCLC model BALB/cA nude mice inoculated with A549 cells
Dosages 20 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 440.88 Formula

C22H21ClN4O4
CAS No. 1010100-07-8 SDF --
Smiles CC1=C(Cl)C=C(NC(=O)NCC2=CC3=C(C=C2)C(=O)N(C3)C4CCC(=O)NC4=O)C=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 40 mg/mL ( (90.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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