CC-885

Catalog No.S8300

For research use only.

CC-885 is a novel cereblon (CRBN) modulator. CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation.

CC-885 Chemical Structure

CAS No. 1010100-07-8

Purity & Quality Control

Choose Selective E3 Ligase Inhibitors

Biological Activity

Description

CC-885 is a novel cereblon (CRBN) modulator. CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation.

Targets
CRBN [1]
()
In vitro

CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation in non-small-cell lung cancer (NSCLC) cells.<sup><a class="sref" href="#s_ref">[1]</a></sup>

In vivo

CC-885 can promote PLK1 ubiquitination and degradation and synergistically inhibit NSCLC with volasertib in NSCLC model BALB/cA nude mice.<sup><a class="sref" href="#s_ref">[1]</a></sup>

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: A549, NCI-H1299
  • Concentrations: 50 nM, 1 mM
  • Incubation Time: 24 h, 48 h
  • Method:

    A549 and NCI-H1299 are treated with 1 mM CC-885 for 24 h and subjected to immunoblot analysis.

Animal Research:

[1]

  • Animal Models: NSCLC model BALB/cA nude mice inoculated with A549 cells
  • Dosages: 20 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

DMSO 40 mg/mL
(90.72 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 440.88
Formula

C22H21ClN4O4

CAS No. 1010100-07-8
Storage 3 years -20°C powder
2 years -80°C in solvent

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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