research use only

CTB Histone Acetyltransferase activator

Name: CTB
Brand: Selleck Chemicals
SKU: E1107
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1107

CTB is a p300 activator and the lowest docked energy for this compound and p300 is 7.72 kcal/mol.

Chemical Structure

Molecular Weight: 343.73

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: Purity: 99.84%

99.84

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Chemical Information, Storage & Stability

Molecular Weight	343.73	Formula	C₁₆H₁₃ClF₃NO₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	451491-47-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Solubility

In vitro
Batch:

DMSO : 69 mg/mL (200.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 17 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.500mg/ml (10.18mM)	Taking the 1 mL working solution as an example, add 50 μL of 70 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.500mg/ml (10.18mM)	Taking the 1 mL working solution as an example, add 50 μL of 70 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	CTB effectively induces apoptosis, up-regulates the expression of P300, and increases the acetylation and total P53 protein levels in MCF-7 cells.^[2]
In vivo	CTB combinated with CpG, and aluminum hydroxide playsa synergistic effect to enhance ClfA_221-550-induced immune responses, which possesses the potential to develop a novel vaccine to prevent infection of S. aureus.^[3]
References	[1] https://pubmed.ncbi.nlm.nih.gov/21355420/ [2] https://pubmed.ncbi.nlm.nih.gov/23977652/ [3] https://pubmed.ncbi.nlm.nih.gov/32501144/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05433181	Not yet recruiting	SARS-CoV-2	University of Pennsylvania	February 2025	Phase 1\|Phase 2
NCT06344559	Not yet recruiting	Healthy	Rutgers The State University of New Jersey	May 1 2024	Not Applicable
NCT06347055	Not yet recruiting	Nicotine Dependence	University of Missouri-Columbia	April 15 2024	Not Applicable
NCT06301334	Not yet recruiting	Pain Mangement of Thoracotomy	Sohag University	March 1 2024	Not Applicable
NCT05646732	Recruiting	Post Traumatic Stress Disorder\|PTSD	Allyson Rosen\|National Institute of Mental Health (NIMH)\|Palo Alto Veterans Institute for Research	August 2 2023	Not Applicable
NCT05983211	Recruiting	Amyotrophic Lateral Sclerosis	Sunnybrook Health Sciences Centre	June 1 2023	Not Applicable

Tech Support

Handling Instructions

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