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CA-074

Name: CA-074
Brand: Selleck Chemicals
SKU: S9834
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S9834

CA-074 inhibits cathepsin B with a Ki value of 2-5 nM.

Chemical Structure

Molecular Weight: 383.44

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SDS
Datasheet

Related Targets	PROTAC Dyes Antineoplastic and Immunosuppressive Antibiotics ADC Cytotoxin Selection Antibiotics for Transfected Cell Antibiotics for Mammalian Cell Culture ADC Linker Molecular Glues Hydrotropic Agents Antibiotics for Plant Cell Culture
Other Others Inhibitors	Furimazine (PBI 3939) Guanidinoacetic acid Blebbistatin Polybrene (Hexadimethrine Bromide) Osthole Silibinin (NSC 651520) Carbazochrome sodium sulfonate (AC-17) Palmitic acid Ursolic Acid Vitexin

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Chemical Information, Storage & Stability

Molecular Weight	383.44	Formula	C18H29N3O6	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	134448-10-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

In vivo	Intraperitoneally injection of compound CA-074 into rats potently and selectively inhibits cathepsin B activity. Intravenously administration of CA-074 immediately after the ischaemic insult saves 67% of CA1 neurons from delayed neuronal death on day 5 in eight monkeys undergoing 20 min brain ischaemia: the extent of inhibition is excellent in three of eight and good in five of eight monkeys.
References	[1] https://www.ncbi.nlm.nih.gov/2013329 [2] https://www.ncbi.nlm.nih.gov/12437121 [3] https://www.ncbi.nlm.nih.gov/9751144

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