Cefotaxime

Catalog No.S4720

For research use only.

Cefotaxime is a third-generation cephalosporin antibiotic and has broad spectrum activity against Gram positive and Gram negative bacteria.

Cefotaxime Chemical Structure

CAS No. 63527-52-6

Purity & Quality Control

Choose Selective Antibiotics for Plant Cell Culture Inhibitors

Biological Activity

Description Cefotaxime is a third-generation cephalosporin antibiotic and has broad spectrum activity against Gram positive and Gram negative bacteria.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 455.47
Formula

C16H17N5O7S2

CAS No. 63527-52-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04647331 Recruiting -- Infective Endocarditis Uppsala University June 1 2021 --
NCT01272999 Completed Other: No intervention Acute Otitis Media|Mastoiditis Pfizer May 21 2010 --
NCT00187655 Completed Drug: Cefotaxime Focus Groups University of California San Francisco January 2004 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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