CVT-313

For research use only.

Catalog No.S6537

CVT-313 Chemical Structure

CAS No. 199986-75-9

CVT-313 is a potent CDK2 inhibitor with an IC50 of 0.5 microM in vitro. It has no effect on other, nonrelated ATP-dependent serine/threonine kinases.

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Biological Activity

Description CVT-313 is a potent CDK2 inhibitor with an IC50 of 0.5 microM in vitro. It has no effect on other, nonrelated ATP-dependent serine/threonine kinases.
Targets
CDK2 [1]
(Cell-free assay)
0.5 μM
In vitro

In cells exposed to CVT-313, hyperphosphorylation of the retinoblastoma gene product is inhibited, and progression through the cell cycle is arrested at the G1/S boundary. The growth of mouse, rat, and human cells in culture is also inhibited by CVT-313 with the IC50 for growth arrest ranging from 1.25 to 20 μM. CVT-313 inhibits Rb hyperphosphorylation[1].

Protocol

Cell Research:

[1]

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  • Cell lines: MRC-5 cells
  • Concentrations: 12.5 μM
  • Incubation Time: 24 h
  • Method:

    --


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Rat carotid artery model of restenosis
  • Dosages: 0.025, 0.25, 0.75, 1.25 mg/kg
  • Administration: intraluminal
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 80 mg/mL (199.76 mM)
Ethanol 80 mg/mL (199.76 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 400.47
Formula

C20H28N6O3

CAS No. 199986-75-9
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)N1C=NC2=C(N=C(N=C21)N(CCO)CCO)NCC3=CC=C(C=C3)OC

In vivo Formulation Calculator (Clear solution)

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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CDK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID