For research use only.

Catalog No.S2555 Synonyms: A-56268

2 publications

Clarithromycin  Chemical Structure

Molecular Weight(MW): 747.95

Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.

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10mM (1mL in DMSO) USD 130 In stock
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Biological Activity

Description Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections.
CYP3A4 [1]
In vitro

Clarithromycin suppresses this production in a dose-dependent manner in both monocytes and THP-1 cells. Clarithromycin regulates three other promoters that have either the NF-kappa B or the AP-1 binding sequences: two synthetic (pAP-1-Luc and pNF-kappa B-Luc) and one naturally occurring (ELAM-Luc). [1] Clarithromycin suppresses NF-kappaB activation induced by TNF-alpha in U-937 and Jurkat cells in a concentration-related manner. Clarithromycin inhibits NF-kappaB activation induced by TNF-alpha in U-937, Jurkat, and A549 cells and PBMC and by SEA in PBMC. Clarithromycin prevents NF-kappaB-dependent reporter gene expression in U-937 cells. [2] Clarithromycin results in a significant suppression of production of each cytokine in 71% and a significant increase in 29% of the human monocytes. [3] Clarithromycin inhibits tumor necrosis factor (TNF)-alpha-induced IL-8 gene expression in a dose- and incubation time-dependent manner. Clarithromycin represses AP-1 binding in TNF-alpha-treated BET-1A cells. Clarithromycin represses IL-8 gene transcription mainly via the AP-1 binding site in human bronchial epithelial cells. [4] Clarithromycin suppresses IL-1 beta gene expression in human nasal epithelial cells stimulated by H. influenzae endotoxin (HIE). Clarithromycin suppresses intercellular adhesion molecule-1 gene expression in nasal fibroblasts stimulated by IL-1 beta. Clarithromycin reduces DNA-binding activity of NF-kappa B in both human nasal epithelial cells and fibroblasts stimulated by HIE or IL-1 beta, respectively. [5]


Solubility (25°C)

In vitro DMSO 25 mg/mL warmed (33.42 mM)
Water Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 747.95


CAS No. 81103-11-9
Storage powder
in solvent
Synonyms A-56268

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03800550 Completed Drug: Bedaquiline|Drug: Clarithromycin Healthy Janssen Research & Development LLC February 13 2019 Phase 1
NCT03043989 Terminated Drug: Docetaxel|Drug: Cabazitaxel|Drug: Clarithromycin Prostate Cancer Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Maryland Technology Development Corporation March 21 2017 Phase 1

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P450 (e.g. CYP17) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID