Colistin Sulfate

Catalog No.S4029 Synonyms: Polymixin E Sulfate

For research use only.

Colistin (Polymixin E) is a cyclic cationic decapeptide linked to a fatty acid side chain, it belongs to a group of similarly structured bacterial antimicrobial peptides.

Colistin Sulfate  Chemical Structure

CAS No. 1264-72-8

Selleck's Colistin Sulfate has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Colistin (Polymixin E) is a cyclic cationic decapeptide linked to a fatty acid side chain, it belongs to a group of similarly structured bacterial antimicrobial peptides.
In vitro

Colistin (2 μg/mL) is active against most strains of Escherichia coli and P. aeruginosa, and all species of Enterobacter, Salmonella, Shigella, Pasteurella, Brucella, and Bordetella. Proteus, Serratia, Providencia. Colistin inhibits 225 strains of P.aeruginosa with MIC90 and MIC50 of 6.3 μg/mL and 1.6μg/mL, respectively. Colistin sulfate is approved only for topical and oral use because of its toxicity. [1] Colistin sulfate is administered orally (tablets or syrup) for bowel decontamination and topically as a powder for the treatment of bacterial skin infections. Colistin interacts with the bacterial membrane through electrostatic interactions between the cationic polypeptide (colistin) and anionic lipopolysaccharide (LPS) molecules in the outer membrane of the gram-negative bacteria, leading to derangement of the cell membrane. Colistin displaces magnesium (Mg+2) and calcium (Ca+2), which normally stabilize the LPS molecules, from the negatively charged LPS, leading to a local disturbance of the outer membrane. Colistin has also potent anti-endotoxin activity. [2] Colistin sulfate produces a strong postantibiotic effects against Acinetobacter baumannii ranging from 2.5 hours to 7.0 hours in a concentration-dependent manner. [3]

In vivo Colistin sulfate (5%, i.m.) causes the muscle circumference to appear erythematic in mice. Colistin sulfate (i.m., 15 mg/kg/day for 5 days) causes obvious neurotoxicity to piglets with moderate granular degenerations in the epithelial tissues from kidney and liver of mice. Colistin sulfate (i.m.) at dose of 2.5 mg/kg and 5.0 mg/kg results in Cmax of 3.73 mg/mL and 6.40 mg/mL, Tmax of 32 min and 34 min, t(1/2beta) of 256 min and 264 min, and absolute bioavailability of 95.94% and 88.45% in mice. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight
Formula

H2SO4.xUnspecified

CAS No. 1264-72-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O)C(C)O.CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC2CC

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04775238 Recruiting Other: Silver nanoparticles|Other: Copper nanoparticles Nosocomial Infections Sohag University February 27 2021 Not Applicable
NCT04208945 Unknown status Drug: Colistin Pneumonia Ventilator-associated|Gram-Negative Pneumonia University of Thessaly December 2019 Not Applicable
NCT03971877 Completed Diagnostic Test: Rapid Polymyxin NP test Colistin Resistance in Bacteria University Hospital Bordeaux December 16 2019 --
NCT04489459 Unknown status Drug: Colistin|Drug: Meropenem|Drug: Tigecycline Treatment of Blood Stream Infections Due to Multidrug-Resistant Klebsiella Pneumoniae Al-Azhar University September 21 2019 Phase 4
NCT03597841 Completed Drug: Combination therapy Klebsiella Pneumonia|Bacteremia Koç University June 25 2018 --

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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