Home Metabolism Dehydrogenase inhibitor CM10

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CM10 Dehydrogenase inhibitor

Cat.No.S0522

CM10 is a potent and selective inhibitor of aldehyde dehydrogenase 1A family (ALDH1A) with IC50 of 1700 nM, 740 nM and 640 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively. This compound exhibits anti-cancer activity.
CM10 Dehydrogenase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 321.42

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S052201 DMSO]64 mg/mL]false]Ethanol]64 mg/mL]false]Water]Insoluble]false Purity: 99.28%
99.28

Chemical Information, Storage & Stability

Molecular Weight 321.42 Formula
C20H23N3O
 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 692269-09-3 -- Storage of Stock Solutions

Synonyms N/A Smiles CCCN1C2=CC=CC=C2N=C1NCC3=CC=CC(=C3O)CC=C

Solubility

In vitro
Batch:

DMSO : 64 mg/mL (199.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 64 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
ALDH1A3 [1]
(Cell-free assay)
640 nM
ALDH1A2 [1]
(Cell-free assay)
740 nM
ALDH1A2 [1]
(Cell-free assay)
740 nM
ALDH1A1 [1]
(Cell-free assay)
1700 nM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04461665 Completed
Vitamin D Deficiency
Shih Chien University|Shin Kong Wu Ho-Su Memorial Hospital
 August 18 2015 Not Applicable

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