Carbimazole

Catalog No.S4048

For research use only.

Carbimazole is an imidazole antithyroid agent.

Carbimazole Chemical Structure

CAS No. 22232-54-8

Purity & Quality Control

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Biological Activity

Description Carbimazole is an imidazole antithyroid agent.
In vitro

Carbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland).[1] Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine). [2]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 38 mg/mL
(204.04 mM)
Ethanol 15 mg/mL
(80.54 mM)
Water Insoluble

Chemical Information

Molecular Weight 186.23
Formula

C7H10N2O2S

CAS No. 22232-54-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCOC(=O)N1C=CN(C1=S)C

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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