Carbimazole

Catalog No.S4048

Carbimazole Chemical Structure

Molecular Weight(MW): 186.23

Carbimazole is an imidazole antithyroid agent.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Purity & Quality Control

Biological Activity

Description Carbimazole is an imidazole antithyroid agent.
In vitro

Carbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland).[1] Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine). [2]

Protocol

Solubility (25°C)

In vitro DMSO 38 mg/mL (204.04 mM)
Ethanol 15 mg/mL (80.54 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 186.23
Formula

C7H10N2O2S

CAS No. 22232-54-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03064542 Recruiting Hyperthyroidism Clinical Nutrition Research Centre Singapore|Agency for Science Technology and Research August 18 2017 --
NCT03064542 Recruiting Hyperthyroidism Clinical Nutrition Research Centre Singapore|Agency for Science Technology and Research August 18 2017 --
NCT01436994 Completed Paediatric Thyrotoxicosis Newcastle-upon-Tyne Hospitals NHS Trust July 2004 Phase 3
NCT01436994 Completed Paediatric Thyrotoxicosis Newcastle-upon-Tyne Hospitals NHS Trust July 2004 Phase 3
NCT00430547 Completed Graves'' Ophthalmopathy Barwon Health|University of Melbourne|National Health and Medical Research Council Australia August 2003 Not Applicable
NCT00430547 Completed Graves'' Ophthalmopathy Barwon Health|University of Melbourne|National Health and Medical Research Council Australia August 2003 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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