Cabazitaxel

Catalog No.S3022 Synonyms: RPR-116258A, XRP6258, TXD 258

Cabazitaxel  Chemical Structure

Molecular Weight(MW): 835.93

Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide.

Size Price Stock Quantity  
In DMSO USD 570 In stock
USD 170 In stock
USD 270 In stock
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3 Customer Reviews

  • ABCB1 functional inhibition using elacridar re-sensitizes TaxR and DU145-DTXR cells to cabazitaxel treatment. A. TaxR and DU145-DTXR cells were subjected to cell growth assays using either vehicle (DMSO), elacridar (0.5μM), cabazitaxel (1nM), or a combination of elacridar and cabazitaxel. Cells were counted 72 hours post-treatment. B. TaxR and DU145-DTXR cells were treated with either vehicle (DMSO), elacridar (0.5μM), cabazitaxel (1nM), or a combination of both elacridar and cabazitaxel for 72 hours. Whole cell lysates were then prepared and subjected to western blot analysis using indicated antibodies. Tubulin served as a loading control. c-PARP = cleaved-PARP, C = control (DMSO) treatment, Elac = elacridar, CTX = cabazitaxel. All data is presented as percent of control mean ± standard deviation. * = p-value ≤ 0.05.

    Mol Cancer Ther, 2017, 16(10):2257-2266. Cabazitaxel purchased from Selleck.

    Combination effect of cabazitaxel with drugs that target the PI3K-pathway simultaneously: LNCaP cells were treated with the indicated combination of the drugs and analyzed as described in Methods and Figure ​Figure3

    Oncotarget, 2016, 7(46):76181-76196. Cabazitaxel purchased from Selleck.

  • Viability of PC-3R and PC-3 cells treated with docetaxel and cabazitaxel. The 3,000 cells seeded in a 96-well plate were treated with docetaxel or cabazitaxel at indicated concentrations for 72 hours and subjected to WST assay (n=5).

    Urol Oncol, 2015, 33(9):385.e15-20.. Cabazitaxel purchased from Selleck.

Purity & Quality Control

Choose Selective Microtubule Associated Inhibitors

Biological Activity

Description Cabazitaxel is a semi-synthetic derivative of a natural taxoid that kills cancer cells by inhibiting cell division and growth. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide.
Features A semi-synthetic derivative of a natural taxoid.
Targets
Microtubule [1]
(Cell-free assay)
In vitro

Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%. Cabazitaxel is rapidly and extensively metabolised in numerous metabolites. Cabazitaxel demonstrates activity in several murine and human resistant cell lines. [1] With a 4-day exposure to cabazitaxel, cytotoxicity is noted with relatively low cabazitaxel concentrations. Cabazitaxel shows high antitumor activity in 3 human colorectal cell lines (HCT-116, HCT-8, and HT-29). [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MCF7 cells NEDnXJBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNR2Y4KGOnbHzzJIJ6KE2WVDDhd5NigSxiR1m1NF0yNjF7IH7N NV\n[WJFOjR2MEW3NFI>
human DU145 cells MmDJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUPIcXBrT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hTFVzNEWgZ4VtdHNiYomgUXRVKGG|c3H5MEBKSzVyPUGuOFMhdk1? M2rDO|I1PDB3N{Cy
human A549 cells NXjhdoZkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnH1S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRVU1QSClZXzsd{BjgSCPVGSgZZN{[XluIFnDOVA:OS52ODDuUS=> M4PXXFI1PDB3N{Cy
human A431 cells M1nqfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYC1To5DT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSTR|MTDj[YxteyCkeTDNWHQh[XO|YYmsJGlEPTB;MT60PEBvVQ>? MmXFNlQ1ODV5MEK=
human HeLa cells M1f0fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFzWdpJIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJ\UyjIHPlcIx{KGK7IF3UWEBie3Ojef-8kEBKSzVyPUGuPEBvVQ>? M4HoSFI1PDB3N{Cy
human K562 cells MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkTIS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gT|U3OiClZXzsd{BjgSCPVGSgZZN{[Xl? NFvxNoozPDRyNUewNi=>
human HL60 cells MmHSS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDIUFYxKGOnbHzzJIJ6KE2WVDDhd5NigQ>? MmjjNlQ1ODV5MEK=

... Click to View More Cell Line Experimental Data

In vivo In accompanying models, Cabazitaxel is noted to have significant antitumor activity. In murine tumor xenografts (colon C38 and pancreas P03), Cabazitaxel elicites complete tumor regressions. Using SF-295 and U251 human glioblastoma cell lines, both orthotopic and subcutaneous murine xenografts are generated. Cabazitaxel treatment leads to complete regression in the majority of subcutaneously implanted tumors. Furthermore, in orthotopic models, Cabazitaxel leads to complete tumor regression in 4 out of 10 U251 tumors. [2]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (119.62 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 835.93
Formula

C45H57NO14

CAS No. 183133-96-2
Storage powder
in solvent
Synonyms RPR-116258A, XRP6258, TXD 258

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03110588 Recruiting Metastatic Prostate Cancer University of Alabama at Birmingham|Astellas Pharma Inc|Sanofi July 1 2018 Phase 1
NCT03419234 Recruiting Castration Levels of Testosterone|Castration-Resistant Prostate Carcinoma|Metastatic Prostate Carcinoma in the Soft Tissue|Prostate Carcinoma Metastatic in the Bone|Stage IV Prostate Adenocarcinoma AJCC v7 ECOG-ACRIN Cancer Research Group|National Cancer Institute (NCI)|Eastern Cooperative Oncology Group February 8 2018 Phase 2
NCT03257891 Recruiting Adrenocortical Carcinoma Azienda Ospedaliera Spedali Civili di Brescia|San Luigi Gonzaga Hospital January 25 2018 Phase 2
NCT03392428 Recruiting Cancer of the Prostate|Metastatic Cancer Australian and New Zealand Urogenital and Prostate Cancer Trials Group|Australian Nuclear Science and Technology Organisation (ANSTO)|Endocyte|Prostate Cancer Foundation of Australia (PCFA)|Australasian Radiopharmaceutical Trials network (ARTnet)|Movember Foundation January 29 2018 Phase 2
NCT02844582 Recruiting Hormone-Resistant Prostate Cancer|Stage IV Prostate Adenocarcinoma University of California Davis|Sanofi December 20 2017 Phase 2
NCT03356912 Enrolling by invitation Prostate Cancer|Castration-resistant Prostate Cancer Consorzio Oncotech November 22 2017 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What is the elimination half-life of cabazitaxel?

  • Answer:

    According to the paper report, the elimination half-life of cabazitaxel is 95h.

Microtubule Associated Signaling Pathway Map

Related Microtubule Associated Products0

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID