Chloroprocaine HCl

Catalog No.S4284

For research use only.

Chloroprocaine HCl is a local anesthetic during surgical procedures.

Chloroprocaine HCl Chemical Structure

CAS No. 3858-89-7

Purity & Quality Control

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Biological Activity

Description Chloroprocaine HCl is a local anesthetic during surgical procedures.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 61 mg/mL
(198.55 mM)
Water 61 mg/mL
(198.55 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 307.22


CAS No. 3858-89-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03260972 Withdrawn Drug: Chloroprocaine Hcl 2% Inj|Drug: Normal saline Cesarean Section Complications|Pain Johns Hopkins University June 2021 Phase 3
NCT03805438 Completed Drug: Chloroprocaine Hcl 3% Inj Cerclage Cervical Duke University|University of Arkansas February 7 2019 Phase 4
NCT03805503 Completed Drug: Chloroprocaine 1% Injectable Solution Spinal Anesthesia University Hospital Ghent September 16 2015 Phase 4
NCT02287870 Completed Drug: Chloroprocaine|Drug: Lidocaine Anesthesia Jinling Hospital China January 2008 Phase 4

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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